Genomes and Genes
Gene Symbol: FBXW7
Description: F-box and WD repeat domain containing 7
Alias: AGO, CDC4, FBW6, FBW7, FBX30, FBXO30, FBXW6, SEL-10, SEL10, hAgo, hCdc4, F-box/WD repeat-containing protein 7, F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase, F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila), F-box protein FBW7, F-box protein FBX30, F-box protein SEL-10, archipelago, homolog of C elegans sel-10
Publications273 found, 100 shown here
- Materials aspects of implantable cardiac pacemaker leadsS D Bruck
Biomaterials and Medical Devices Consulting Group, Stephen D. Bruck Associates, Inc, Rockville, MD 20851
Med Prog Technol 13:149-60. 1988..Although silicone has been used widely, some years ago Pellethane (a segmented polyetherurethane-urea) has been introduced as an alternate lead insulator, chiefly because ..
- Melatonin in relation to cellular antioxidative defense mechanismsR J Reiter
Department of Cellular and Structural Biology, University of Texas Health Science Center, USA
Horm Metab Res 29:363-72. 1997Melatonin's actions in organisms are more widespread than originally envisaged. Over three decades ago, the changing pattern of nocturnal melatonin production was found to be the signal for the annual cycle of reproduction in ..
- 125 years of public health in the UKL J Donaldson
Department of Health, Room 111, Richmond House, 79 Whitehall, London SW1A 2NS, England
J R Soc Promot Health 121:146-51. 2001..The focus of public health has recently been strongly on health services. This reached its apogee a few years ago but is also now rapidly changing...
- The SV40 large T antigen contains a decoy phosphodegron that mediates its interactions with Fbw7/hCdc4Markus Welcker
Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
J Biol Chem 280:7654-8. 2005..of LT to Fbw7 occurs via a decoy phospho-epitope within the C terminus of LT that closely mimics the consensus Cdc4 phospho-degron found within Fbw7 substrates...
- Structure of a Fbw7-Skp1-cyclin E complex: multisite-phosphorylated substrate recognition by SCF ubiquitin ligasesBing Hao
Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Mol Cell 26:131-43. 2007..Cyclin E degradation is triggered by multisite phosphorylation, which induces binding to the SCF(Fbw7) ubiquitin ligase complex...
- Multisite phosphorylation by Cdk2 and GSK3 controls cyclin E degradationMarkus Welcker
Divisions of Clinical Research and Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Mol Cell 12:381-92. 2003..abundance: phosphorylation of cyclin E on T380 by its associated CDK allows binding to the receptor subunit, Fbw7, of the SCFFbw7 ubiquitin ligase...
- The Fbw7 tumor suppressor targets KLF5 for ubiquitin-mediated degradation and suppresses breast cell proliferationDong Zhao
The Center for Cell Biology and Cancer Research, Albany Medical College, Albany, NY 12208, USA
Cancer Res 70:4728-38. 2010b>Fbw7 is a tumor suppressor frequently inactivated in cancers. The KLF5 transcription factor promotes breast cell proliferation and tumorigenesis through upregulating FGF-BP...
- The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemiaBenjamin J Thompson
Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
J Exp Med 204:1825-35. 2007..We report that the E3 ligase FBW7 targets NOTCH1 for ubiquitination and degradation...
- Negative regulation of HIF-1α by an FBW7-mediated degradation pathway during hypoxiaJessica M Cassavaugh
Department of Pharmacology, College of Medicine, University of Vermont, Burlington, Vermont 05405, USA
J Cell Biochem 112:3882-90. 2011..b>FBW7 is an E3 ubiquitin ligase that recognizes proteins phosphorylated by glycogen synthase kinase 3β (GSK3β) and ..
- The intracellular domain of Jagged-1 interacts with Notch1 intracellular domain and promotes its degradation through Fbw7 E3 ligaseMi Yeon Kim
Hormone Research Center, School of Biological Sciences and Technology, Chonnam National University, Gwangju, Republic of Korea
Exp Cell Res 317:2438-46. 2011..Furthermore, JICD accelerates the protein degradation of Notch1-IC via Fbw7-dependent proteasomal pathway...
- The Fbw7 tumor suppressor regulates nuclear factor E2-related factor 1 transcription factor turnover through proteasome-mediated proteolysisMadhurima Biswas
Department of Laboratory Medicine and Pathology, University of California, Irvine, California 92697, USA
J Biol Chem 286:39282-9. 2011..We report here that Nrf1 is a short-lived protein that is targeted by F-box protein Fbw7, which is the substrate-specifying component of SCF (Skp1-Cul1-Fbox protein-Rbx1)-type ubiquitin ligase for ..
- GSK-3β regulates cell growth, migration, and angiogenesis via Fbw7 and USP28-dependent degradation of HIF-1αDaniela Flügel
Department of Biochemistry and Biocenter Oulu, University of Oulu, Oulu, Finland
Blood 119:1292-301. 2012..GSK-3)-induced phosphorylation and recruitment of the ubiquitin ligase and tumor suppressor F-box and WD protein Fbw7. Further, experiments with GSK-3β and Fbw7-deficient cells revealed that GSK-3β and Fbw7-dependent HIF-1α ..
- Parkin-dependent degradation of the F-box protein Fbw7β promotes neuronal survival in response to oxidative stress by stabilizing Mcl-1Susanna Ekholm-Reed
Department of Cell and Molecular Biology, The Scripps Research Institute, La Jolla, California, USA
Mol Cell Biol 33:3627-43. 2013..present evidence for a neuronal ubiquitin ligase cascade involving parkin and the multisubunit ubiquitin ligase SCF(Fbw7β). Specifically, parkin targets the SCF substrate adapter Fbw7β for proteasomal degradation...
- FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitorsJennifer O'Neil
Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
J Exp Med 204:1813-24. 2007..6%) primary T-ALL samples harbored either a mutation or homozygous deletion of the gene FBW7, a ubiquitin ligase implicated in NICD turnover...
- The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homologC Oberg
Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institute, SE 171 77 Stockholm, Sweden
J Biol Chem 276:35847-53. 2001..In conclusion, these data reveal the importance of ubiquitination and proteasome-mediated degradation for the activity and turnover of Notch ICs, and demonstrate that mSel-10 plays a key role in this process...
- NOTCH1/FBXW7 mutation identifies a large subgroup with favorable outcome in adult T-cell acute lymphoblastic leukemia (T-ALL): a Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL) studyVahid Asnafi
Université Paris 5 Descartes and Assistance Publique Hôpitaux de Paris AP HP and Hematology Department, Hopital Necker Enfants Malades, Paris, France
Blood 113:3918-24. 2009..NOTCH1 and/or FBXW7 mutations both lead to activation of the NOTCH1 pathway and are among the most frequent mutations in T-ALL...
- Mutation of hCDC4 leads to cell cycle deregulation of cyclin E in cancerSusanna Ekholm-Reed
Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, USA
Cancer Res 64:795-800. 2004b>hCDC4, the gene that encodes the F-box protein responsible for targeting cyclin E for ubiquitin-mediated proteolysis, has been found to be mutated in a number of primary cancers and cancer-derived cell lines...
- Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptorN Gupta-Rossi
Unité de Biologie Moléculaire de l Expression Génique, FRE 2364, CNRS, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
J Biol Chem 276:34371-8. 2001..SEL-10, an F-box protein of the Cdc4 family, was isolated in a genetic screen for Lin12/Notch-negative regulators in Caenorhabditis elegans...
- Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligaseD M Koepp
Department of Biochemistry and Molecular Biology, Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX, 77030, USA
Science 294:173-7. 2001..b>Fbw7 associates specifically with phosphorylated cyclin E, and SCFFbw7 catalyzes cyclin E ubiquitination in vitro...
- Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell linesK H Moberg
Massachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA
Nature 413:311-6. 2001..In a screen for Drosophila mutants that display increased cell proliferation, we identified archipelago, a gene encoding a protein with an F-box and seven tandem WD (tryptophan-aspartic acid) repeats...
- Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell lineH Strohmaier
Department of Molecular Biology, MB 7, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Nature 413:316-22. 2001..The gene encoding hCdc4 was found to be mutated in a cell line derived from breast cancer that expressed extremely high levels of cyclin E.
- hCDC4 gene mutations in endometrial cancerCharles H Spruck
Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
Cancer Res 62:4535-9. 2002..profile of expression is the result of periodic transcription and ubiquitin-mediated proteolysis directed by SCF(hCdc4)...
- SEL-10 interacts with presenilin 1, facilitates its ubiquitination, and alters A-beta peptide productionJinhe Li
Department of Neurobiology, Computer Aided Drug Design, Pharmacia Corporation, Kalamazoo, Michigan 49001, USA
J Neurochem 82:1540-8. 2002..SEL-10 protein is a homologue of yeast Cdc4, a member of the SCF (Skp1-Cdc53/CUL1-F-box protein) E2-E3 ubiquitin ligase family...
- BRAF and FBXW7 (CDC4, FBW7, AGO, SEL10) mutations in distinct subsets of pancreatic cancer: potential therapeutic targetsEric S Calhoun
Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231, USA
Am J Pathol 163:1255-60. 2003..the mutational status of the serine/threonine kinase BRAF and the cyclin E regulator FBXW7 (CDC4, FBW7, AGO, SEL10) related to two distinct pancreatic carcinoma subsets: the medullary KRAS2-wild-type and the cyclin E ..
- The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signalingAbdolrahman S Nateri
Mammalian Genetics Laboratory, Cancer Research UK, London Research Institute, Lincoln s Inn Fields Laboratories, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
Science 303:1374-8. 2004..We report that in neurons the stability of c-Jun is regulated by the E3 ligase SCF(Fbw7), which ubiquitinates phosphorylated c-Jun and facilitates c-Jun degradation...
- The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradationMarkus Welcker
Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Proc Natl Acad Sci U S A 101:9085-90. 2004..Myc proteins regulate cell growth and division and are implicated in a wide range of human cancers. We show here that Fbw7, a component of the SCF(Fbw7) ubiquitin ligase and a tumor suppressor, promotes proteasome-dependent c-Myc turnover ..
- Recognition of phosphodegron motifs in human cyclin E by the SCF(Fbw7) ubiquitin ligaseXin Ye
Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 279:50110-9. 2004Turnover of cyclin E is controlled by SCF(Fbw7). Three isoforms of Fbw7 are produced by alternative splicing...
- Ras activity regulates cyclin E degradation by the Fbw7 pathwayAlex C Minella
Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Proc Natl Acad Sci U S A 102:9649-54. 2005The Skp1-Cullin1 F-box protein-Fbw7 ubiquitin ligase regulates phosphorylation-dependent cyclin E degradation, and disruption of this pathway is associated with genetic instability and tumorigenesis...
- Control of lipid metabolism by phosphorylation-dependent degradation of the SREBP family of transcription factors by SCF(Fbw7)Anders Sundqvist
Ludwig Institute for Cancer Research, Box 595, Husargatan 3, S 751 24 Uppsala, Sweden
Cell Metab 1:379-91. 2005..Here, we identify a phosphodegron in SREBP1a that serves as a recognition motif for the SCF(Fbw7) ubiquitin ligase...
- Ubiquitylation of cyclin E requires the sequential function of SCF complexes containing distinct hCdc4 isoformsFrank van Drogen
Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
Mol Cell 23:37-48. 2006..targeted for proteasomal degradation by phosphorylation-dependent multiubiquitylation via the ubiquitin ligase SCF(hCdc4)...
- hCDC4 variation in osteosarcomaTaiqiang Yan
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, M5G 1X5
Cancer Genet Cytogenet 169:138-42. 2006The hCDC4 gene (also known as Fbw7 or Archipelago) encodes an F-box protein that is responsible for targeting cyclin E for Skp1-cullin-F box protein (SCF) ubiquitination and proteosomal degradation...
- Fbw7 isoform interaction contributes to cyclin E proteolysisWei Zhang
Department of Genetics, Cell Biology and Development, University of Minnesota Twin Cities, Minneapolis, MN, USA
Mol Cancer Res 4:935-43. 2006..The putative tumor-suppressor protein Fbw7 (hAgo/hCdc4) is a specificity factor for the Skp1-Cul1-F-box protein ubiquitin ligase complex and targets a number of proto-..
- Fbw7/hCDC4 dimerization regulates its substrate interactionsMarkus Welcker
Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, Washington 98109, USA
Cell Div 2:7. 2007The Fbw7 ubiquitin ligase promotes the rapid degradation of several important oncogenes, such as cyclin E, c-Myc, c-Jun, and Notch. The two fission yeast homologs of Fbw7, pop1 and pop2, have previously been shown to dimerize...
- The ubiquitin-specific protease USP28 is required for MYC stabilityNikita Popov
Institute of Molecular Biology and Tumor Research, Emil Mannkopff Str 2, 35033 Marburg, Germany
Nat Cell Biol 9:765-74. 2007..High expression levels of USP28 are found in colon and breast carcinomas, and stabilization of MYC by USP28 is essential for tumour-cell proliferation...
- Fbw7 and Usp28 regulate myc protein stability in response to DNA damageNikita Popov
Institute of Molecular Biology and Tumor Research, Emil Mannkopff Str 2, Marburg, Germany
Cell Cycle 6:2327-31. 2007..We show here that this decline is in part due to proteasomal degradation and that it is mediated by the Fbw7 ubiquitin ligase...
- FBXW7/hCDC4 is a general tumor suppressor in human cancerShahab Akhoondi
Cancer Center Karolinska, Karolinska Hospital, Stockholm, Sweden
Cancer Res 67:9006-12. 2007..b>Fbxw7 (or hCdc4), a member of the F-box family of proteins, which are substrate recognition components of the ..
- FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiationMarkus Welcker
Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109, USA
Nat Rev Cancer 8:83-93. 2008b>FBW7 (F-box and WD repeat domain-containing 7) is the substrate recognition component of an evolutionary conserved SCF (complex of SKP1, CUL1 and F-box protein)-type ubiquitin ligase...
- SCFCdc4 acts antagonistically to the PGC-1alpha transcriptional coactivator by targeting it for ubiquitin-mediated proteolysisBrian L Olson
Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
Genes Dev 22:252-64. 2008..We identified SCF(Cdc4) as an E3 ubiquitin ligase that regulates PGC-1alpha through ubiquitin-mediated proteolysis...
- Fbw7 regulates the activity of endoreduplication mediators and the p53 pathway to prevent drug-induced polyploidyS Finkin
Department of Experimental Medicine and Cancer Research, Hebrew University Medical School, Jerusalem, Israel
Oncogene 27:4411-21. 2008b>Fbw7 is a tumor suppressor that is mutated in numerous cancers. It encodes an E3 ubiquitin ligase, whose ability to decrease the levels of pivotal regulators of cell growth and proliferation underlies its tumor suppressor function...
- Both SCF(Cdc4alpha) and SCF(Cdc4gamma) are required for cyclin E turnover in cell lines that do not overexpress cyclin EOlle Sangfelt
Cancer Center Karolinska, Karolinska sjukhuset, Department of Oncology Pathology, Stockholm, Sweden
Cell Cycle 7:1075-82. 2008..of cyclin E is regulated by phosphorylation and the activity of the ubiquitin ligase SCF(Cdc4) (also known as SCF(Fbw7))...
- The Fbxw7/hCdc4 tumor suppressor in human cancerYingMeei Tan
Department of Tumor Cell Biology, Sidney Kimmel Cancer Center, San Diego, CA 92121, USA
Cancer Lett 271:1-12. 2008Fbxw7/hCdc4 is a member of the F-box family of proteins, which function as interchangeable substrate recognition components of the SCF ubiquitin ligases...
- Isoform- and cell cycle-dependent substrate degradation by the Fbw7 ubiquitin ligaseJonathan E Grim
Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
J Cell Biol 181:913-20. 2008The SCF(FBW7) ubiquitin ligase degrades proteins involved in cell division, growth, and differentiation and is commonly mutated in cancers...
- FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppressionJian Hua Mao
Cancer Research Institute, University of California at San Francisco, 2340 Sutter Street, San Francisco, CA 94143, USA
Science 321:1499-502. 2008..that mTOR is targeted for ubiquitination and consequent degradation by binding to the tumor suppressor protein FBXW7. Human breast cancer cell lines and primary tumors showed a reciprocal relation between loss of FBXW7 and deletion ..
- A phosphorylation cascade controls the degradation of active SREBP1Maria T Bengoechea-Alonso
Ludwig Institute for Cancer Research, Uppsala University, Biomedical Center, Box 595, Husargatan 3, Uppsala S 751 24, Sweden
J Biol Chem 284:5885-95. 2009..Phosphorylation of Thr-426 and Ser-430 in SREBP1a creates a docking site for the ubiquitin ligase Fbw7, resulting in the degradation of the transcription factor...
- FBXW7 and NOTCH1 mutations in childhood T cell acute lymphoblastic leukaemia and T cell non-Hodgkin lymphomaMyoung Ja Park
Department of Haematology Oncology, Gunma Children s Medical Centre, Gunma, Japan
Br J Haematol 145:198-206. 2009Mutation analysis of FBXW7 and NOTCH1 genes was performed in 55 T cell acute lymphoblastic leukaemia (T-ALL) and 14 T cell non-Hodgkin lymphoma (T-NHL) patients who were treated on the Japan Association of Childhood Leukaemia Study (..
- The impact of NOTCH1, FBW7 and PTEN mutations on prognosis and downstream signaling in pediatric T-cell acute lymphoblastic leukemia: a report from the Children's Oncology GroupA Larson Gedman
Graduate Program in Cancer Biology, Wayne State University School of Medicine, Detroit, MI, USA
Leukemia 23:1417-25. 2009We explored the impact of mutations in the NOTCH1, FBW7 and PTEN genes on prognosis and downstream signaling in a well-defined cohort of 47 patients with pediatric T-cell acute lymphoblastic leukemia (T-ALL)...
- Somatic mutations of the CDC4 (FBXW7) gene in hereditary colorectal tumorsMichiko Miyaki
Hereditary Tumor Research Project, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan
Oncology 76:430-4. 2009Cdc4 (Fbxw7) is a potential tumor suppressor that regulates ubiquitination and proteolysis of multiple targets such as cyclin E, c-Myc, c-Jun and Notch...
- Loss of FBXW7, a cell cycle regulating gene, in colorectal cancer: clinical significanceMasaaki Iwatsuki
Department of Surgical Oncology, Medical Institute of Bioregulation, Kyushu University, Beppu 874 0838, Japan
Int J Cancer 126:1828-37. 2010This study focused on a cell cycle regulatory gene, FBXW7, which ubiquitinates c-Myc and cyclin E and promotes exit from the cell cycle...
- Prognostic implications of NOTCH1 and FBXW7 mutations in adult acute T-lymphoblastic leukemiaClaudia D Baldus
Charite, University Hospital Berlin, Campus Benjamin Franklin, Department of Hematology and Oncology, Hindenburgdamm 30 12203 Berlin, Germany
Haematologica 94:1383-90. 2009..However, the results of studies on the prognostic significance of NOTCH1 mutations in adult T-lymphoblastic leukemia remain controversial...
- The Fbw7/human CDC4 tumor suppressor targets proproliferative factor KLF5 for ubiquitination and degradation through multiple phosphodegron motifsNing Liu
Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China
J Biol Chem 285:18858-67. 2010..However, the mechanisms regulating protein stability remain poorly understood. In this study, the tumor suppressor Fbw7, a component of the SCF complex (SCF(Fbw7)) E3 ubiquitin ligase, specifically promoted the degradation and ..
- Tumor suppressor Fbxw7 regulates TGFβ signaling by targeting TGIF1 for degradationM T Bengoechea-Alonso
School of Medicine and Medical Science, UCD Conway Institute, University College Dublin, Dublin, Ireland
Oncogene 29:5322-8. 2010..The tumor suppressor Fbxw7 is the substrate-recognition factor of a ubiquitin ligase that targets multiple proteins for degradation, ..
- F-box and WD repeat domain-containing 7 regulates intestinal cell lineage commitment and is a haploinsufficient tumor suppressorRocio Sancho
Mammalian Genetics Laboratory, CR UK London Research Institute, Lincoln s Inn Fields Laboratories, London, UK
Gastroenterology 139:929-41. 2010The E3 ubiquitin ligase F-box and WD repeat domain-containing 7 (Fbw7) degrades several proto-oncogenes including c-Myc, cyclinE, Notch1, and c-Jun...
- MicroRNA-223 regulates cyclin E activity by modulating expression of F-box and WD-40 domain protein 7Yanfei Xu
Department of Medicine, Division of Hematology Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
J Biol Chem 285:34439-46. 2010..Fbw7 is a bona fide tumor suppressor, and loss-of-function mutations in FBXW7 have been identified in diverse human tumors...
- Int6 regulates both proteasomal degradation and translation initiation and is critical for proper formation of acini by human mammary epitheliumJ Suo
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
Oncogene 30:724-36. 2011..Our data further show that Int6 binds SRC3 and its ubiquitin ligase Fbw7, thus perhaps mediating the interaction between SRC3-Fbw7 and proteasomes...
- Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liverIchiro Onoyama
Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Higashi ku, Fukuoka, Fukuoka, Japan
J Clin Invest 121:342-54. 2011..The F-box family member F-box- and WD repeat domain-containing 7 (Fbxw7; also known as Fbw7, SEL-10, hCdc4, and hAgo) targets for degradation proteins with wide-ranging functions, and uncovering its in vivo role has been ..
- Reduced expression of ubiquitin ligase FBXW7 mRNA is associated with poor prognosis in breast cancer patientsMutsuko Ibusuki
Department of Breast and Endocrine Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
Cancer Sci 102:439-45. 2011b>FBXW7 is a cell cycle regulatory gene that ubiquitinates positive cell cycle regulators such as c-Myc and cyclin E, allowing for cell cycle exit...
- Serum- and glucocorticoid-inducible kinase 1 (SGK1) controls Notch1 signaling by downregulation of protein stability through Fbw7 ubiquitin ligaseJung Soon Mo
Hormone Research Center, School of Biological Sciences and Technology, Chonnam National University, Gwangju 500 757, Republic of Korea
J Cell Sci 124:100-12. 2011..Notch1 and Fbw7 mutations both lead the activation of the Notch1 pathway and are found in the majority of patients with the ..
- SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destructionHiroyuki Inuzuka
Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
Nature 471:104-9. 2011..Loss of FBW7, which encodes a tumour-suppressor protein, is frequently found in various types of human cancer, including breast ..
- MiRNA-27a controls FBW7/hCDC4-dependent cyclin E degradation and cell cycle progressionMikael Lerner
Department of Oncology Pathology Cancer Center Karolinska CCK, Karolinska Institutet, Stockholm, Sweden
Cell Cycle 10:2172-83. 2011The F-box protein FBW7/hCDC4 is a tumor suppressor that acts as the substrate recognition component of an SCF ubiquitin ligase that targets numerous oncoproteins for proteasomal degradation...
- Fbxw7α- and GSK3-mediated degradation of p100 is a pro-survival mechanism in multiple myelomaLuca Busino
NYU Cancer Institute, New York University School of Medicine, 522 First Avenue, SRB 1107, New York, New York 10016, USA
Nat Cell Biol 14:375-85. 2012b>Fbxw7α is a member of the F-box family of proteins, which function as the substrate-targeting subunits of SCF (Skp1/Cul1/F-box protein) ubiquitin ligase complexes...
- Pten regulates Aurora-A and cooperates with Fbxw7 in modulating radiation-induced tumor developmentYong Won Kwon
Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720, USA
Mol Cancer Res 10:834-44. 2012..Here, we show that Aurora-A is targeted for ubiquitination and subsequent degradation by the F-box protein FBXW7 in a process that is regulated by GSK3β...
- [Expression of Fbxw7 and its correlation with cell proliferation in human hepatocellular carcinoma]Zhen Yu Zhou
Department of Hepatobiliary Surgery, First Affiliated Hospital, Medical College, Xi an Jiaotong University, Xi an 710061, China
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 28:1303-6. 2012To observe the expression of Fbxw7 and explore its correlation with cell proliferation of hepatocellular carcinoma (HCC).
- Prognostic significance of Fbw7 in human melanoma and its role in cell migrationYabin Cheng
Department of Dermatology and Skin Science, Jack Bell Research Centre, Vancouver Coastal Health Research Institute, University of British Columbia, Vancouver, British Columbia, Canada
J Invest Dermatol 133:1794-802. 2013The E3 ubiquitin ligase Fbw7 (F-box and WD repeat domain-containing 7) is broadly considered as a tumor suppressor because of its role in the turnover of several well-known oncoproteins...
- The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stabilityBryan King
Howard Hughes Medical Institute and NYU Cancer Institute, NYU School of Medicine, New York, NY 10016, USA
Cell 153:1552-66. 2013..One such recurrent mutation targets the binding pocket of the ubiquitin ligase Fbxw7. Missense FBXW7 mutations are prevalent in various tumors, including T cell acute lymphoblastic leukemia (T-ALL)...
- Fbxw7 is an independent prognostic marker and induces apoptosis and growth arrest by regulating YAP abundance in hepatocellular carcinomaKangsheng Tu
Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi an Jiaotong University, Xi an, Shaanxi 710061, China
Mol Cancer 13:110. 2014The E3 ubiquitin ligase Fbxw7 functions as a general tumor suppressor by targeting several well-known oncoproteins for ubiquitination and proteasomal degradation...
- Inactivation of hCDC4 can cause chromosomal instabilityHarith Rajagopalan
The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
Nature 428:77-81. 2004..Here we report the identification of mutations in hCDC4 (also known as Fbw7 or Archipelago) in both human colorectal cancers and their precursor lesions...
- A nucleolar isoform of the Fbw7 ubiquitin ligase regulates c-Myc and cell sizeMarkus Welcker
Divisions of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Curr Biol 14:1852-7. 2004The human tumor suppressor Fbw7/hCdc4 functions as a phosphoepitope-specific substrate recognition component of SCF ubiquitin ligases that catalyzes the ubiquitination of cyclin E , Notch , c-Jun and c-Myc ...
- Rapamycin inhibits FBXW7 loss-induced epithelial-mesenchymal transition and cancer stem cell-like characteristics in colorectal cancer cellsYuli Wang
Department of Anatomy and Key Laboratory of Experimental Teratology, Ministry of Education, Shandong University School of Medicine, 44 Wenhuaxilu, Jinan, Shandong 250012, PR China
Biochem Biophys Res Commun 434:352-6. 2013..In this study, we explore whether FBXW7 plays any role in metastatic process...
- The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligaseWenyi Wei
Department of Medical Oncology, Dana Farber Cancer Institute and Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Cancer Cell 8:25-33. 2005..c-Myc, we report here that phosphorylation of c-Jun by GSK3 creates a high-affinity binding site for the E3 ligase Fbw7, which targets c-Jun for polyubiquitination and proteasomal degradation...
- Plk2 regulates centriole duplication through phosphorylation-mediated degradation of Fbxw7 (human Cdc4)Onur Cizmecioglu
Cell cycle Control and Carcinogenesis F045, German Cancer Research Center DKFZ, Im Neuenheimer Feld 242, 69120 Heidelberg, Germany
J Cell Sci 125:981-92. 2012..Here, we show that Plk2 directly targets the F-box protein F-box/WD repeat-containing protein 7 (Fbxw7), which is a regulator of the ubiquitin-mediated degradation of cyclin E...
- SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradationG Wu
Department of Pathology, Columbia University, New York, New York 10032, USA
Mol Cell Biol 21:7403-15. 2001..Thus, SEL-10 functions to promote the ubiquitination of Notch proteins; however, the fates of these proteins may differ...
- Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7Masayoshi Yada
Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Maidashi, Higashi ku, Fukuoka, Fukuoka, Japan
EMBO J 23:2116-25. 2004..We now show that the F-box protein Fbw7 interacts with and thereby destabilizes c-Myc in a manner dependent on phosphorylation of MB1...
- The methylation status of FBXW7 beta-form correlates with histological subtype in human thymomaZhaodi Gu
Department of Molecular Pathology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, Miyagi 980 8575, Japan
Biochem Biophys Res Commun 377:685-8. 2008b>FBXW7 is reported to be a tumor suppressor gene, and the functional inactivation of FBXW7 has been reported in various human tumors...
- p53-Altered FBXW7 expression determines poor prognosis in gastric cancer casesTakehiko Yokobori
Department of Surgery, Medical Institute of Bioregulation, Kyushu University, Beppu, Japan
Cancer Res 69:3788-94. 2009A molecular target associated with the progression of gastric cancer has not yet been uncovered. FBXW7 is a tumor suppressor gene transcriptionally controlled by p53 that plays a role in the regulation of cell cycle exit and reentry via ..
- Prognostic implications of NOTCH1 and FBXW7 mutations in adults with T-cell acute lymphoblastic leukemia treated on the MRC UKALLXII/ECOG E2993 protocolMarc R Mansour
Department of Haematology, University College London, UCL Cancer Institute, WC1E 6BT, United Kingdom
J Clin Oncol 27:4352-6. 2009Notch pathway activation by mutations in either NOTCH1 and/or FBXW7 is one of the most common molecular events in T-cell acute lymphoblastic leukemia (T-ALL) and, in pediatric disease, predicts for favorable outcome...
- Inactivation of FBXW7/hCDC4-β expression by promoter hypermethylation is associated with favorable prognosis in primary breast cancerShahab Akhoondi
Departments of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden
Breast Cancer Res 12:R105. 2010Mutational inactivation of the FBXW7/hCDC4 tumor suppressor gene (TSG) is common in many cancer types, but infrequent in breast cancers. This study investigates the presence and impact of FBXW7/hCDC4 promoter methylation in breast cancer.
- Fbxw7β resides in the endoplasmic reticulum membrane and protects cells from oxidative stressAkinobu Matsumoto
Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
Cancer Sci 102:749-55. 2011Oxidative stress has been implicated in cancer initiation and progression. Fbxw7 (also known as Fbw7, SEL-10, hCdc4, or hAgo) is the F-box protein subunit of an Skp1-Cul1-F-box (SCF)-type ubiquitin ligase complex that plays a central ..
- Nucleophosmin and its AML-associated mutant regulate c-Myc turnover through Fbw7 gammaPaola Bonetti
Department of Experimental Oncology, European Institute of Oncology, 20141 Milan, Italy
J Cell Biol 182:19-26. 2008..Because Fbw7 induces degradation of other growth-promoting proteins, the NPM-Fbw7 interaction emerges as a central tumor ..
- [CD34+ cells: biological aspects]F Benedetti
Cattedra di Ematologia,
Tumori 82:S3-13. 1996..Attempts to "purge" the bone marrow of patients affected by low-grade non-Hodgkin lymphoma were done several years ago at Dana Farber Institute, strongly suggesting the importance of tumor cells left in the inoculum in modifying the ..
- [The impact of cancer on the healing status of patients]E Cortesi
Cattedra di Oncologia Medica, Dipartimento di Medicina Sperimentale e Patologia, Universita La Sapienza, Roma
Tumori 84:S20-3. 1998..The QVonc (Quality of Life in Oncology) Project started five years ago from the common interest of medical oncologists who felt the need to make a careful study on some aspects regarding ..
- Pain experienced by patients hospitalized at the National Cancer Institute of Milan: research project "towards a pain-free hospital"C Ripamonti
Rehabilitation and Palliative Care Unit, National Cancer Institute of Milan, Italy
Tumori 86:412-8. 2000..A 3-year Research Project "Towards a Pain-free Hospital", which began one year ago, is ongoing at the National Cancer Institute of Milan. The research is organized in three subsequent steps...
- Does calcium aggravate and cause hypertension?R B Singh
Medical Hospital and Research Centre, Moradabad, India
Acta Cardiol 42:445-67. 1987Albert Szent-Gyorgyi around 30 years ago proposed that "ions were the powerful tools of life as it developed in oceans"...
- [Incidence of resistance and risk factors for resistance in Mycobacterium tuberculosis. A retrospective study of 1,055 patients of a specialty hospital 1984 to 1993]J Borchardt
Pneumologie 50:28-35. 1996..35 patients, who had been treated within the last 5 yrs, and for 65 patients, who had been treated more than 5 yrs ago, were 57 and 17%, respectively (OR 6.6; 95% CI 2.9-16.6)...
- [Pulmonary melioidosis in a German Southeast Asia tourist]K Riecke
, Immunologie und Laboratoriums-medizin, Lungenklinik Heckeshorn, Berlin
Pneumologie 51:499-502. 1997HISTORY AND CLINICAL FINDINGS: A patient who returned from a 3-year stay in Thailand and India one year ago, was admitted with fever of 38.5 degrees C and productive cough for the last four weeks...
- A rare case of malignant T-cell non-hodgkin lymphoma in a HTLV 1 carrier with history of diffuse large B-cell non-hodgkin lymphomaFarahnaz Vafaiezadeh
Cancer Institute, Tehran University of Medical Science, Iran
Clin Lymphoma Myeloma Leuk 10:E42. 2010..He had a history of diffuse large B-cell NHL since 14 months ago with involvement of the vallecula, tonsil, base of the tongue, and tip of epiglottis that pathology reviewed two ..
- [A neutropenic acute myeloid leukemia patient complicated with chronic otitis media due to Aspergillus niger and yeast-like fungi caused by superinfection]K Itoh
First Department of Internal Medicine, Saitama Medical School
Kansenshogaku Zasshi 73:618-22. 1999..A 51-year-old male was admitted because a third relapse of AML in March 1998. Two years ago, he was diagnosed as having chronic otitis media involving the VII cranial nerve due to Pseudomonas aeruginosa ..
- A systematic overview of chemotherapy effects in Hodgkin's diseaseL Brandt
Department of Oncology, University Hospital, Lund, Sweden
Acta Oncol 40:185-97. 2001..and limited field radiotherapy are effective treatment options and, using the regimens available 10-20 years ago, 40-50% of the patients are cured...
- Internal medicine residency training and outcomesC H Griffith
Department of Internal Medicine, University of Kentucky College of Medicine, USA
J Gen Intern Med 12:390-6. 1997..However, the published studies in this area are for the most part retrospective and were conducted 10 to 15 years ago. The full extent of the untoward (or the beneficial) effects of internal medicine residency training on patients' ..
- Chronic behavioral disorders of human REM sleep: a new category of parasomniaC H Schenck
Minnesota Regional Sleep Disorders Center, Hennepin County Medical Center, University of Minnesota, Minneapolis 55415
Sleep 9:293-308. 1986..REM sleep neurobehavioral disorders constitute another category of parasomnia, replicate findings from 21 years ago in cats receiving pontine tegmental lesions, and offer additional perspectives on human behavior, neurophysiology, ..
- Modulation of programmed cell death by medicinal plantsU Thatte
Department of Pharmacology and Therapeutics, Seth GS Medical College, Parel, Mumbai, India
Cell Mol Biol (Noisy-le-grand) 46:199-214. 2000Programmed cell death (apoptosis), a form of cell death, described by Kerr and Wyllie some 20 years ago, has generated considerable interest in recent years...
- Properties of aeromonads and their occurrence and hygienic significance in drinking waterD van der Kooij
, KIWA AG
Zentralbl Bakteriol Mikrobiol Hyg B 187:1-17. 1988..About 100 years ago, bacteria identical with Aeromonas spp. have already been isolated from drinking water...
- [Guidelines: some considerations on one of the cultural instruments on which the switch in the National Health System can be based]R Lionetto
Servizio di Epidemiologia Clinica e Sperimentazioni Controllate, E.O. Ospedali Galliera, Genova
Ital Heart J Suppl 1:617-31. 2000..Guidelines for medical practice are not innovative tools, since their history began at least 20 years ago. They are produced with increasing frequency in North America, and similar developments are taking place in Europe...
- Clinical and biochemical evidence of endothelial cell dysfunction in the pregnancy syndrome preeclampsiaJ M Roberts
Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco 94143
Am J Hypertens 4:700-8. 1991..Despite intensive research since its recognition 100 years ago, our lack of understanding is evidenced by therapy which remains empiric, early delivery...
- [A case report--typhoid fever complicated with liver and gallbladder abscess, treated for long-time as fever of unknown origin]I Kawashima
Department of Internal Medicine, Kawasaki Municipal Hospital
Kansenshogaku Zasshi 71:788-92. 1997..He had noticed high fever since one month ago, and had been treated with prednisolone with the diagnosis of fever of unknown origin in a hospital...
- [High-dose chemotherapy and peripheral hemtopoietic cells (PBPC) in solid tumors]G Rosti
Oncologia Medica Ravenna, Istituto Oncologico Romagnoto, Ravenna
Tumori 82:S19-22. 1996..clear reduction of the toxic death rate to 1% in 1995 for breast cancer patients compared with 20% of fifteen years ago. Germ cell tumors in responding relapse after salvage chemotherapy seem to be ideal candidates for ABMT/PBPC ..
- Malaria epidemiological situation in Italy and evaluation of malaria incidence in Italian travelersR Romi
Laboratorio di Parassitologia, Istituto Superiore di Sanit, Roma, Italy
J Travel Med 8:6-11. 2001BACKGROUND: Malaria was endemic throughout the country until it was eradicated nearly 50 years ago. Since then, mainly imported malaria cases have been reported to the National Health Service, with an increasing trend...
- [A case of empyema caused by Salmonella enteritidis in a patient with sequela of pulmonary tuberculosis]H Suzuki
Department of Pulmonary Diseases, Tokyo Metropolitan Komagome General Hospital, Japan
Kansenshogaku Zasshi 70:382-5. 1996..He had a history of pulmonary tuberculosis 45 years ago. His chest X-ray and CT showed the presence of air-fluid level in the left pleural cavity with thickening and ..
- Multiple genotypes of Taenia solium--ramifications for diagnosis, treatment and controlAkira Ito
Department of Parasitology, Asahikawa Medical College, Asahikawa 078 8510, Japan
Acta Trop 87:95-101. 2003..It was estimated that these two genotypes emerged approximately 4-8 x 10(5) years ago. These results together with recent study of the ancient of human taeniid cestodes emerged several MYA in Africa, ..
- The importance of radiating leg pain in assessing health outcomes among patients with low back pain. Results from the Veterans Health StudyA J Selim
Center for Health Quality, Outcomes, and Economic Research, Bedford Health Services Research and Development Field Program, Veterans Administration Medical Center, Massachusetts, USA
Spine (Phila Pa 1976) 23:470-4. 1998..identified through patient reports of ever having had low back pain, of low back pain that began more than 3 months ago, and of a health-care visit for low back pain in the past year...
- "Remnants of feudalism"? Women's health and their utilization of health services in rural ChinaO Anson
Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
Women Health 30:105-23. 1999Almost five decades ago, the Chinese Communist Party wished to abolish all "remnants of feudalism," including the patriarchal social order...
- It all began with Ronald Ross: 100 years of malaria research and control in Sierra Leone (1899-1999)M J Bockarie
Papua New Guinea Institute of Medical Research, Madang, Papua New Guinea
Ann Trop Med Parasitol 93:213-24. 1999It was in Sierra Leone, 100 years ago in 1899, that human malarial parasites were first observed in wild-caught Anopheles gambiae and An. funestus, the principal vectors of malaria in Africa...
Research Grants109 found, 100 shown here
- Phylogenomics and functional diversification of the Heterochromatin Protein 1 genMIA TAUNA LEVINE; Fiscal Year: 2012..Only three HP1-like genes are currently annotated in the human genome, described over a decade ago by homology to the original three Drosophila HP1-like genes...
- Randy D Blakely; Fiscal Year: 2016..have largely been studies through pharmacological and genetic manipulation of genes identified two decades or more ago. In the current application, we capitalize on a robust, forward genetic approach to identify and characterize novel ..
- Variation in M. tuberculosis in response to host selectionSarah Fortune; Fiscal Year: 2009..In these studies, we expect to provide fundamental insights into the mechanisms and targets of diversifying immune selection in M. tuberculosis. ..
- Bradley A Malin; Fiscal Year: 2016DESCRIPTION (provided by applicant): When the Human Genome Project was completed almost ten years ago it cost millions of dollars to sequence an individual's genome...
- Regressive evolution of pigmentation in the Mexican cavefish, Astyanax mexicanusJessica A Lehoczky; Fiscal Year: 2010Approximately 10,000 years ago, a river-dwelling tetra, Astyanax mexicanus invaded multiple caves in the Sierra de El Abra region of Central Mexico...
- The Role of RNA Interference in West Nile Virus DiversificationDouglas E Brackney; Fiscal Year: 2010..Using short-hairpin RNAs in Aim 1 we will either induce (WNV-specific ShRNAs) or suppress (dcr-2 and ago-2-specific shRNAs) the RNAi response in mosquito and chicken cell culture and assess the impacts on WNV genetic ..
- Emergence of developmental and genomic complexity in a basal vertebrateMarianne Bronner; Fiscal Year: 2013..The existence of an adaptive immune system in the lamprey, a jawless basal vertebrate, was posited 40 years ago based on histological analysis and classical immune challenge experiments...
- The temporal epigenomic program of Barrett's neoplastic progressionStephen J Meltzer; Fiscal Year: 2013..been reported in many human malignancies and premalignant syndromes, but was first reported in BE and EAC 11 years ago. Tumor suppressor genes affected by hypermethylation at various stages of BN include p16, p14, E-cadherin, APC, and ..
- Stephen J Small; Fiscal Year: 2016..Although enhancers were discovered more than 30 years ago, it is still unclear how they work together within the network of genes that organizes the whole embryo...
- A new technology for preclinical development of functional bispecific antibodiesLee A Henderson; Fiscal Year: 2010..BsAb molecules, low yields, high costs) that have plagued the field of BsAbs since its inception more than 20 years ago. Moreover, an E. coli expression platform would enable molecular engineering (e.g...
- Host and Pathogen Evolution in Lassa FeverPardis Sabeti; Fiscal Year: 2010..The RT-PCR assay is based on a single Lassa strain isolated 2 decades ago in Sierra Leone, and has an estimated sensitivity of 50%...
- ROBERT ALPERT ZUCKER; Fiscal Year: 2016..by applicant): This prospective high-risk family study, the Michigan Longitudinal Study (MLS) began 27 years ago to characterize the development of risk for alcohol use disorder (AUD) among children (2nd generation or G2s) ..
- ACADEMIC TRAINING IN TRAUMA AND BURNSDavid M Young; Fiscal Year: 2012..A faculty of 16 MDs, PhDs, and MD/PhDs has been assembled in an orderly evolution since our inception 19 years ago. The faculty encompasses diverse but well interconnected areas of expertise that is capable of training in depth ..
- Evolution of a bacterial genome encoding increased virulence: the genomics of HelMark H Forsyth; Fiscal Year: 2012DESCRIPTION (provided by applicant): The discovery of the gastric pathogen Helicobacter pylori nearly 30 years ago has drastically altered the treatment of peptic ulcer disease...
- Revisiting Challenged Findings to Determine Social and Cognitive AbilitiesJulie J Neiworth; Fiscal Year: 2012..a species of a New World monkey, one which split from a common evolutionary lineage with humans 40 million years ago, can discriminate sequence changes used in human language parsing and can think about the intentions and goals of ..
- Institute for Clinical and Translational Research (KL2)DANIEL ERNEST FORD; Fiscal Year: 2011..fortunate to have the foundation of strong training and degree programs in clinical research, started over 15 years ago. Resources include a K30 curriculum development grant, two K12 grants for postdoctoral and junior faculty career ..
- HELICOBACTER PYLORI GENOME SEQUENCE EVOLUTIONDOUGLAS EUGENE BERG; Fiscal Year: 2010..were Asian-like, whereas those from urban Peruvians (who are also of primarily Asian ancestry >12,000 yrs ago) seemed mostly European genetically...
- A singular opportunity to determine the evolutionary genetics of retroviral invasALFRED LOUIS ROCA; Fiscal Year: 2013..their ubiquity, until recently all identified ERVs had entered their host germline thousands or millions of years ago. Many ERVs have undergone mutations, deletions and recombination, and many retroviruses that gave rise to ERVs may ..
- A Computerized Adaptive Testing Version of the ASIStephen F Butler; Fiscal Year: 2012..Developed more than quarter century ago, concerns have mounted about the psychometric performance of the ASI, particularly as evaluated in light of modern ..
- John F Hurdle; Fiscal Year: 2016..We chartered our long-term goal five decades ago: to create and sustain a modern, adaptive, and relevant training environment that promotes research excellence...
- Translational Breast Cancer Research Training ProgramSuzanne Aw Fuqua; Fiscal Year: 2012..This is a resubmission of competitive renewal of a Training Program begun 5 years ago which has supported 14 PhD or MD postdoctoral trainees...
- BIOGENESIS OF HYDROGENOSOMES OF A TRICHOMONAD PARASITEPATRICIA JEAN JOHNSON; Fiscal Year: 2013..and assist in understanding how energy-generating organeUes evolved in the first eukaryotic cells 2-3 billion years ago. To this end, our overall goals are to understand properties of biogenesis and Ievolution of this organelle and ..
- Deneen M Wellik; Fiscal Year: 2016..The Training Program in Organogenesis, initiated 14 years ago, is an integral part of the educational mission of the Center...
- David R Liu; Fiscal Year: 2015..At the start of the original granting period eight years ago, our laboratory initiated a program to develop a new approach to the synthesis and discovery of bioactive small ..
- Juan Luis Mendoza; Fiscal Year: 2016..translational and cancer therapeutic applications are based on a pioneering study published more than ten years ago suggesting that IFN diversification through in vitro evolution could yield molecules with enhanced functional ..
- Affinity maturation via in vitro evolution at the lab bench-topGEOFFREY A CHANG; Fiscal Year: 2013..have the same revolutionary impact that polymerase chain reaction (PCR) machines had on molecular biology decades ago. This innovative method will allow the broad biomedical research community to quickly generate highly specific ..
- 2011 Microbial Population Biology Gordon Research ConferenceJAMES JEFFREY BULL; Fiscal Year: 2011..Recent years have seen the emergence of HIV, SARS, West Nile (in the U.S.), MRSA, and a new H1N1 pandemic a year ago. While the treatment and mechanistic study of diseases typically falls within the domains of clinicians and ..
- SCOP: A Revitalized Foundation for Studies of Protein Structure and EvolutionJohn Marc Chandonia; Fiscal Year: 2013..However, neither database has changed its basic design since early releases-15 years ago in the case of SCOP...
- Paul S Frenette; Fiscal Year: 2015..BM) microenvironment promotes the differentiation of lineage- committed blood precursors was suggested 50 years ago by Marcel Bessis where he described in seminal studies the erythroblastic island, a structure made of a central ..
- NOVEL BIOMARKERS FOR MECHANISTIC DIAGNOSIS OF THE ANTIPHOSPHOLIPID SYNDROMEJACOB RAND; Fiscal Year: 2010..currently diagnosed through empirical tests for antiphospholipid (aPL) antibodies that were developed over 25 years ago - the aPL immunoassays which were derived from the "biologic false positive syphilis" test and a coagulation ..
- Leber Hereditary Optic Neuropathy: Gene Therapy TrialJohn Guy; Fiscal Year: 2012..disorders affecting the eye, nervous system and heart, some that have been clinically characterized over a century ago, but they are now known to be a spectrum of molecularly defined diseases...
- Center for the Epigenetics of Common Human DiseaseAndrew P Feinberg; Fiscal Year: 2013..The Center for the Epigenetics of Common Human Disease was created four years ago to begin to develop the interface between epigenetics and epidemiologic-based phenotype studies, recognizing that ..
- Massively parallel measurement of mitochondrial DNA mutation during human aging Joseph Hiatt; Fiscal Year: 2013DESCRIPTION (provided by applicant): Nearly fifty years ago, Harman proposed that aging-related loss of tissue integrity and function is caused by damage to cellular macromolecules by free radicals produced largely in mitochondria...
- Educating High School Students and Their Families about Clinical Research (PhaseGerry R Boss; Fiscal Year: 2010..Since its inception in San Diego over 20 years ago,it has been highly successful, and has been disseminated to schools throughout the country...
- Spatial Epidemiology of Syphilis and Gonorrhea in North CarolinaWilliam C Miller; Fiscal Year: 2010..For example, geographical core areas, a phenomenon described over 20 years ago, remains an important construct today...
- JENNIFER LYNN ST SAUVER; Fiscal Year: 2016..The REP currently supports 40 government-funded grants, and since its initial funding 42 years ago, more than 1,800 manuscripts have been published in the peer-reviewed literature, including 214 since our last ..
- Research Cooperative Agreement to Promote the Health of People with IntellectualSTEPHEN CORBIN; Fiscal Year: 2011..Special Olympics research projects are designed to take maximal advantage of that diversity. Five years ago, Special Olympics University (SOU) had many questions about the health and well being of people with ID, but had ..
- Laurie E Comstock; Fiscal Year: 2016..Bacteriocin production by intestinal Bacteroides spp. was reported many years ago, however, no bacteriocin gene was cloned, nor was the mechanisms of action described...
- Prevention of Complications in ThalassemiaElliott P Vichinsky; Fiscal Year: 2011..of the Research Initiative for the Prevention of Complications of Thalassemia Since its establishment 17 years ago, the NCTC has developed a growing statewide program dedicated to delivering comprehensive multidisciplinary care, ..
- Mechanistic regulation of tumor specific forms of cyclin E in breast cancerNIKKI A DELK; Fiscal Year: 2010..The E3 ubiquitin ligase specificity factor, Fbw7, is an F-box protein that binds to and mediates cyclin E degradation in normal cells, making Fbw7 a candidate ..
- Vitamin D and Estrogen Action in Bone: Concerted Role for hnRNPs in the C FamilyJohn S Adams; Fiscal Year: 2013DESCRIPTION (provided by applicant): Twenty-five years ago we began to investigate an outbreak of rachitic bone disease in adolescent, female New World primates residing at the Los Angles Zoo...
- Mechanisms of tumor suppression by Fbw7Jonathan E Grim; Fiscal Year: 2010..b>Fbw7 is an F-box protein that targets cyclin E, Myc, Notch and Jun for degradation...
- PATHOPHYSIOLOGY OF THE ENDOTHELIUMFrancis W Luscinskas; Fiscal Year: 2013..Dysregulation of these endothelial functions promotes inflammatory disease processes. Since its inception 30 years ago, this Program Project has combined cell and molecular biological, biochemical, morphological, molecular genetic, ..
- Interplay Between Tissue Architecture and Nuclear Organization in the DNA DamagePierre Alexandre Vidi; Fiscal Year: 2013..My career goal is to expand my current mentored project on DNA repair, initiated three years ago, as an academic principal investigator and to develop innovative strategies to fight the cancer burden...
- Role of the SCF/Fbxo15 ubiquitin ligase in stem cells and cancer biologyMichele Pagano; Fiscal Year: 2012..Notably, only 9 of the 69 human SCF ligases (containing the F-box proteins 2TrCP1, 2TrCP2, Fbxw7, Skp2, Fbxl3, Fbxl5, Fbxo1, Fbxo4, and Fbxo6) have well-established/accepted substrates and functions...
- Danny A Riley; Fiscal Year: 2014..Shock wave vibration injury, recognized over 90 years ago, has been neglected. This knowledge gap must be addressed because severe HAVS can onset in 2...
- Modeling TH17 Cells in Acute GVHDJONATHAN STUART SERODY; Fiscal Year: 2010..Several years ago multiple different investigators found a new subset of T cells that generate the cytokines IL- 17A, IL-17F, IL-21, ..
- RADIATION-INDUCED THYROID CANCERHeinz Ulrich G Weier; Fiscal Year: 2011..More than 10 years ago, we and our collaborators in Germany began to archive thyroid tumor tissues from patients who underwent ..
- David M Roth; Fiscal Year: 2016..A relationship between ANP, caveolae and caveolins was proposed nearly two decades ago. ANP is present within caveolae, closely associated with Cav-3 and may be secreted via caveolae from cardiac ..
- Serpil C Erzurum; Fiscal Year: 2016..The excessive growth of the vascular endothelial cells is the focus of our research. Four years ago, we established methods for culture of pulmonary artery endothelial cells (PAEC) from PAH and donor lungs...
- The New England Family Study: Fifty Year Post-Perinatal Follow-Up for Life CourseERIC contact LOUCKS; Fiscal Year: 2010..Maternal cortisol levels during pregnancy (approximately 50 years ago) will be measured from banked serum samples...
- Human Decidual Leukocytes and Their Placental LigandsJACK STROMINGER; Fiscal Year: 2009..involved in human maternal-fetal tolerance, an immunological enigma described by Peter Medawar more than 50 years ago. The fetus in utero bears paternal antigens and should be rejected as a foreign graft by the maternal immune system...
- Zipcode based nano-imaging of hypertensive pulmonary arteriesRubin M Tuder; Fiscal Year: 2010..hemodynamic assessment of pulmonary artery pressures, which has been implemented more than a half a century ago. The most important challenges in SPH are overcoming the lack of early diagnostic tools, lack of noninvasive ..
- miRNAs and epidermal langerhans cell development and functionQing Sheng Mi; Fiscal Year: 2011..Even though LCs were first described more than 100 years ago, their development and immunological functions still remain enigmatic...
- Targeting Siglec-8/-F to treat eosinophil and mast cell related disordersBruce S Bochner; Fiscal Year: 2012..Siglec-8 was discovered by us about a decade ago and is selectively expressed on eosinophils and mast cells...
- Bruce S Bochner; Fiscal Year: 2016..Siglec-8 was discovered by us about a decade ago and is selectively expressed on eosinophils and mast cells...
- Experimental engineering of ovarian grafting to promote angiogenesis for fertilitGLENN LEWIS SCHATTMAN; Fiscal Year: 2010..fertility is still considered 'experimental', though proof of principle was established many years ago in animal models...
- Celiac Disease: From Genetic Risk to Disease DevelopmentSusan L Neuhausen; Fiscal Year: 2009..the development of CD in first-degree relatives of CD cases who previously tested negative five or more years ago. We will perform serologic testing for CD and have the subjects complete a follow-up questionnaire including data ..
- Lung Toxicity of Carbon Nanotubes in Models of Pre-Existing Respiratory DiseaseJAMES CHRISTOPHER BONNER; Fiscal Year: 2010..However, their needle-like structure is reminiscent of asbestos fibers, which were exploited decades ago because of their superior insulating characteristics, but caused a worldwide pandemic of pleural lung cancer (..
- Coenzyme F420-dependent enzymes in mycobacteriaBiswarup Mukhopadhyay; Fiscal Year: 2013..F420, a deazaflavin coenzyme, was discovered 60 years ago in a mycobacterial species, but its biological roles have been studied mostly in the methanogenic archaea where it ..
- TIMOTHY AN THY CHAN; Fiscal Year: 2015..Both PARK2 and FBXW7 (also called hCDC4) encode ubiquitin E3 ligases and are tumor suppressors mutated in a number of cancer types, including GBM...
- Experimental Molecular Vaccines for SchistosomiasisAfzal A Siddiqui; Fiscal Year: 2012..in control via snail eradication and large-scale chemotherapy using praziquantel (a drug developed 30 years ago);this disease continues to spread to new geographic areas...
- Hiroyuki Inuzuka; Fiscal Year: 2015Abstract: The goal of this proposal is to uncover the molecular mechanisms by which the Fbw7 tumor suppressor is implicated in cellular senescence...
- Weight management for improved pregnancy outcomesVictor J Stevens; Fiscal Year: 2012..starting their pregnancies with a body mass index or 30 or greater, a condition that was unusual to rare 50 years ago. Given the serious consequences of added weight gain during pregnancy for obese women, such as gestational diabetes,..
- William R Ledoux; Fiscal Year: 2015..Many patients and physicians are now considering ankle arthroplasty, whereas a decade ago, most would only consider arthrodesis. Although arthrodesis can remove the primary symptom of ESAA (i.e...
- Chi V Dang; Fiscal Year: 2016..In addition, we identified a novel enzyme activity for Rcl, encoded by a Myc target gene that we cloned a decade ago. This novel activity converts deoxynucleotide monophosphate to the respective base and deoxyribose, which could ..
- 2011 Nucleic Acids Gordon Research ConferenceChristopher D Lima; Fiscal Year: 2011..The Gordon Research Conference on Nucleic Acids was established more than 50 years ago and since that time, fundamental discoveries in nucleic acids biology have impacted our understanding in areas ..
- Regulation of Organized Intestinal Lymphoid Tissues by TRANCE/RANKLIfor R Williams; Fiscal Year: 2012..While M cells were first described in the rabbit appendix over 30 years ago and are known to have a central role in uptake of particulate antigens in mucosal tissues while also being ..
- ADAM BRYANT MURPHY; Fiscal Year: 2016..Adam Murphy is an academic urologist who completed residency two years ago. Adam aims to deepen his basic science skills to be a well-rounded translational scientist...
- Developing and Improving the UAB Gnotobiotic Facility.SAMUEL CORBIN CARTNER; Fiscal Year: 2013..The UAB Gnotobiotic Facility was established a decade ago and is now in need of additional space and equipment to accommodate the increased needs of investigators whose ..
- Paul D Gershon; Fiscal Year: 2014..Although this disease is considered to have been eradicated some 35 years ago, the poxviruses, nonetheless, comprise a major family of viruses of medical, ecological and agricultural importance...
- Scripps Translational Science Institute (TL1)ERIC JEFFREY TOPOL; Fiscal Year: 2013..engaged in translational research, enabled by an effective and popular molecular medicine course initiated 3 years ago and numerous faculty who are engaged in this type of research...
- James S Floyd; Fiscal Year: 2016..Concerns about the cardiovascular safety of oral diabetes therapies first emerged over forty years ago, when the first-generation sulfonylurea tolbutamide was found to increase the risk of cardiovascular death in the ..
- Stuart H Orkin; Fiscal Year: 2015..Molecular Developmental Hematopoiesis: The Center of Excellence in Molecular Hematology was established ~15 years ago by the Principal Investigator (S.H. Orkin) and the co-investigator (L.I. Zon)...
- Meng Liu; Fiscal Year: 2016..Narcolepsy is a neurodegenerative sleep disorder affecting almost 1:2000 Americans. Ten years ago the neuropeptide hypocretin (HCRT), also known as orexin, was linked to narcolepsy, and deficiency of HCRT was ..
- Kenneth Coleman; Fiscal Year: 2015..the last class of antibiotics acting against Gram negative species, the fluoroquinolones, was introduced 40 years ago. However, we reasoned that it should be considerably easier to develop a narrow-spectrum antimicrobial acting ..
- Examining Human Behavior in Dengue Prevention Efforts in Iquitos, PeruVALERIE ANDREA PAZ-SOLDAN; Fiscal Year: 2013..Three years ago I found my niche as a social scientist working on dengue prevention, but I need training and mentorship in this new ..
- JOHN ANANDA VAN AALST; Fiscal Year: 2015..Starting 4 years ago, the candidate's clinical practice began experiencing an increase in parents seen for prenatal consultations ..
- Michelle R Arkin; Fiscal Year: 2014..company like Merck represents a watershed moment for schistosomiasis R&D since the discovery of PZQ 40 years ago. The combination of Merck's expertise in statin chemistry and UCSF's parasitological/screening expertise ..
- Qiumin Tan; Fiscal Year: 2015..Much has been learned about SCA1 pathogenesis since the discovery, nearly two decades ago, that it is caused by an expansion of the polyglutamine (polyQ) tract in the Ataxin-1 (ATXN1) protein...
- Pei Zhong; Fiscal Year: 2016..reached the gold standard that was established by the original Dornier HM-3 (EH) lithotripter more than 25 years ago. Therefore, there is a strong desire from both lithotripter manufacturers and practicing urologists to improve the ..
- Mala S Mahendroo; Fiscal Year: 2014..Specifically, we will use RNA-seq and Ago HITS-CLIP (high-throughput sequencing of RNAs isolated by crosslinking immunoprecipitation of Argonaute) ..
- Shi Yong Sun; Fiscal Year: 2015..have suggested that mTOR, raptor and rictor can be degraded through a mechanism involving the E3 ubiquitin ligase FBXW7 (also called FBW7 or CDC4)...
- JOHANNES VAN BERLO; Fiscal Year: 2015..Until a decade ago the heart was considered to be a post-mitotic organ...
- JURGEN T ROHR; Fiscal Year: 2016..A few years ago MTM was identified as a potential lead drug against neurological diseases, arthritis, and for the treatment of ..
- Christos Coutifaris; Fiscal Year: 2016The Penn RMU has been part of the RMN since the Network's inception over twenty two years ago and has played a leadership role in the design, implementation, analysis and publication of many of the RMN's studies...
- Rohit Varma; Fiscal Year: 2016..of the burden of eye disease in AAs are from two population based assessments initiated and conducted 20-28 years ago in Maryland (The Baltimore Eye Survey [1985-88] and The Salisbury Eye Evaluation Project [1993-95](1, 6))...
- 7th World Congress on Itch (WCI)Ethan A Lerner; Fiscal Year: 2013..What started with a handful of people a decade ago will be the 7th World Congress on Itch (WCI)...
- RICHARD ANDREW SPRITZ; Fiscal Year: 2016..Our genetic studies of GV began 15 years ago with basic studies of genetic and clinical epidemiology, followed by candidate gene association studies and ..
- Richard P Sloan; Fiscal Year: 2014..Today, blood pressure (BP) is in a similar position as HR was 40 years ago. While the clinical significance of mean blood pressure (BP) has been accepted for decades, within-subject BP ..
- ARYN HILARY GITTIS; Fiscal Year: 2015..FS inputs from the globus pallidus (GPe);although inputs from the GPe were identified anatomically over ten years ago, a detailed functional characterization of this projection has been sorely lacking...
- Tumor endothelial cell abnormalitiesANDREW CARL DUDLEY; Fiscal Year: 2013..idea that tumors could be eradicated by destroying tumor-associated blood vessels was first proposed over 30 years ago. Today there are about 11 anti-angiogenic drugs in clinical trials...
- Robert Wieder; Fiscal Year: 2015..Dentistry of New Jersey-New Jersey Medical School/University Hospital Cancer Center was established a three years ago. Our program serves a patient population which is primarily form the inner city neighborhoods of Newark, ..
- Michele A La Merrill; Fiscal Year: 2015..women who participated in the Child Health and Development Studies birth cohort study in California over 40 years ago and will involve inter-generational life course analyses...
- Melissa S Stockwell; Fiscal Year: 2016..associated with ARI/ILI epidemiology have changed since previous population-based studies were conducted decades ago. Likewise, modern diagnostic techniques such as reverse transcription polymerase chain reaction (RT-PCR) expands ..
- Huda Y Zoghbi; Fiscal Year: 2016DESCRIPTION (provided by applicant): Methyl-CpG-binding protein 2 (MeCP2) was first purified over twenty years ago and identified as a transcriptional repressor that binds to methylated CpG dinucleotides...
- Sami Barmada; Fiscal Year: 2015..lateral sclerosis (ALS) is the most common motor neuron disease, and despite its initial description over 100 years ago by Jean-Martin Charcot, there remains no effective therapy for the ultimately fatal weakness and muscle atrophy ..
- Luis M de la Maza; Fiscal Year: 2014..Efforts to produce a vaccine against trachoma were initiated decades ago. More recently, with the uncovering of the role of C...
- Kevin D Young; Fiscal Year: 2016..Bacteria exhibit extreme morphological diversity, a fact known since they were first visualized over 300 years ago. Yet only in the last 5-7 years has it become clear that these differences are much more than cosmetic...
- Christopher R McCurdy; Fiscal Year: 2016..Products Neuroscience (CORE-NPN) at The University of Mississippi School of Pharmacy (UM), initiated four years ago through a COBRE grant, has developed a multidisciplinary team committed to evaluating the effects of natural ..