FBXW11

Summary

Gene Symbol: FBXW11
Description: F-box and WD repeat domain containing 11
Alias: BTRC2, BTRCP2, FBW1B, FBXW1B, Fbw11, Hos, F-box and WD repeats protein beta-TrCP2, F-box and WD-40 domain protein 11, F-box and WD-40 domain protein 1B, F-box protein Fbw1b, F-box/WD repeat-containing protein 11, F-box/WD repeat-containing protein 1B, beta-transducin repeat-containing protein 2, homologous to Slimb protein
Species: human

Top Publications

  1. pmc A cytoplasmic tail determinant in HIV-1 Vpu mediates targeting of tetherin for endosomal degradation and counteracts interferon-induced restriction
    Tonya Kueck
    Department of Infectious Disease, King s College London School of Medicine, Guy s Hospital, London, United Kingdom
    PLoS Pathog 8:e1002609. 2012
  2. ncbi SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein
    Takahiro Shirogane
    Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 280:26863-72. 2005
  3. ncbi Holoprosencephaly and preaxial polydactyly associated with a 1.24 Mb duplication encompassing FBXW11 at 5q35.1
    David A Koolen
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, 9101, 6500 HB, Nijmegen, The Netherlands
    J Hum Genet 51:721-6. 2006
  4. pmc Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase
    Hiroyuki Inuzuka
    Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Cancer Cell 18:147-59. 2010
  5. ncbi Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage
    Luca Busino
    European Institute of Oncology, 435 Via Ripamonti, 20141 Milan, Italy
    Nature 426:87-91. 2003
  6. ncbi Polo-like kinase-1 controls proteasome-dependent degradation of Claspin during checkpoint recovery
    Ivan Mamely
    Unidad de Investigacion, Hospital Universitario de Canarias, Ofra s n, La Cuesta, 38320 Tenerife, Spain
    Curr Biol 16:1950-5. 2006
  7. pmc Silencing of both beta-TrCP1 and HOS (beta-TrCP2) is required to suppress human immunodeficiency virus type 1 Vpu-mediated CD4 down-modulation
    Christophe Butticaz
    Institute of Microbiology, University Hospital of Lausanne, Lausanne, Switzerland
    J Virol 81:1502-5. 2007
  8. ncbi Identification of substrates for F-box proteins
    Jianping Jin
    Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA
    Methods Enzymol 399:287-309. 2005
  9. pmc M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP
    Nobumoto Watanabe
    Antibiotics Laboratory, Discovery Research Institute, RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Proc Natl Acad Sci U S A 101:4419-24. 2004
  10. pmc SCF(HOS) ubiquitin ligase mediates the ligand-induced down-regulation of the interferon-alpha receptor
    K G Suresh Kumar
    Department of Animal Biology, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104 6046, USA
    EMBO J 22:5480-90. 2003

Detail Information

Publications149 found, 100 shown here

  1. pmc A cytoplasmic tail determinant in HIV-1 Vpu mediates targeting of tetherin for endosomal degradation and counteracts interferon-induced restriction
    Tonya Kueck
    Department of Infectious Disease, King s College London School of Medicine, Guy s Hospital, London, United Kingdom
    PLoS Pathog 8:e1002609. 2012
    ....
  2. ncbi SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein
    Takahiro Shirogane
    Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 280:26863-72. 2005
    ....
  3. ncbi Holoprosencephaly and preaxial polydactyly associated with a 1.24 Mb duplication encompassing FBXW11 at 5q35.1
    David A Koolen
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, 9101, 6500 HB, Nijmegen, The Netherlands
    J Hum Genet 51:721-6. 2006
    ..1. The duplicated region encompasses seven genes: RANBP17, TLX3, NPM1, FGF18, FBXW11, STK10, and DC-UbP...
  4. pmc Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase
    Hiroyuki Inuzuka
    Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Cancer Cell 18:147-59. 2010
    ..Our results provide insight into the signaling pathways controlling Mdm2 destruction and further suggest that compromised regulation of Mdm2 results in attenuated p53 activity, thereby facilitating tumor progression...
  5. ncbi Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage
    Luca Busino
    European Institute of Oncology, 435 Via Ripamonti, 20141 Milan, Italy
    Nature 426:87-91. 2003
    ..Our results show that beta-TrCP has a crucial role in mediating the response to DNA damage through Cdc25A degradation...
  6. ncbi Polo-like kinase-1 controls proteasome-dependent degradation of Claspin during checkpoint recovery
    Ivan Mamely
    Unidad de Investigacion, Hospital Universitario de Canarias, Ofra s n, La Cuesta, 38320 Tenerife, Spain
    Curr Biol 16:1950-5. 2006
    ..Moreover, our data demonstrate that the degradation of Claspin at the onset of mitosis is an essential step for the recovery of a cell from a DNA-damage-induced cell-cycle arrest...
  7. pmc Silencing of both beta-TrCP1 and HOS (beta-TrCP2) is required to suppress human immunodeficiency virus type 1 Vpu-mediated CD4 down-modulation
    Christophe Butticaz
    Institute of Microbiology, University Hospital of Lausanne, Lausanne, Switzerland
    J Virol 81:1502-5. 2007
    ..Mammals possess a homologue of beta-TrCP1, HOS, which is also named beta-TrCP2...
  8. ncbi Identification of substrates for F-box proteins
    Jianping Jin
    Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA
    Methods Enzymol 399:287-309. 2005
    ..In addition, we describe approaches for the use of immobilized phosphopeptides to identify F-box proteins that recognize particular phosphodegrons...
  9. pmc M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP
    Nobumoto Watanabe
    Antibiotics Laboratory, Discovery Research Institute, RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Proc Natl Acad Sci U S A 101:4419-24. 2004
    ..These results also establish the existence of a feedback loop between Cdc2 and Wee1A in somatic cells that depends on ubiquitination and protein degradation and ensures the rapid activation of Cdc2 when cells are ready to divide...
  10. pmc SCF(HOS) ubiquitin ligase mediates the ligand-induced down-regulation of the interferon-alpha receptor
    K G Suresh Kumar
    Department of Animal Biology, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104 6046, USA
    EMBO J 22:5480-90. 2003
    ..Here we show that IFNAR1 interacts with the Homolog of Slimb (HOS) F-box protein in a phosphorylation-dependent manner, and that this interaction is promoted by interferon alpha (..
  11. ncbi IkappaBalpha ubiquitination is catalyzed by an SCF-like complex containing Skp1, cullin-1, and two F-box/WD40-repeat proteins, betaTrCP1 and betaTrCP2
    H Suzuki
    Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co, Ltd, 21 Miyukigaoka, Ibaraki, Tsukuba shi, 305 8585, Japan
    Biochem Biophys Res Commun 256:127-32. 1999
    ..These results indicate that the long-sought IkappaBalpha-E3 is an SCF-like complex consisting of multiple proteins which are coordinately assembled during phosphorylation of IkappaBalpha in response to external signals...
  12. ncbi Phosphorylation and specific ubiquitin acceptor sites are required for ubiquitination and degradation of the IFNAR1 subunit of type I interferon receptor
    K G Suresh Kumar
    Department of Animal Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 279:46614-20. 2004
    ..We discuss the complexities and specifics of the ubiquitination and degradation of IFNAR1, which is a beta-Trcp substrate that undergoes degradation via a lysosomal pathway...
  13. pmc SAG/ROC-SCF beta-TrCP E3 ubiquitin ligase promotes pro-caspase-3 degradation as a mechanism of apoptosis protection
    Mingjia Tan
    Department of Radiation Oncology, University of Michigan Comprehensive Cancer Center, 1500 East Medical Center Drive, Ann Arbor, MI 48109 0936, USA
    Neoplasia 8:1042-54. 2006
    ..Thus, pro-caspase-3 appears to be a substrate of SAG/ROC-SCF(beta-TrCP) E3 Ub ligase, which protects cells from apoptosis through increased apoptosis threshold by reducing the basal level of pro-caspase-3...
  14. pmc SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase
    Jianping Jin
    Department of Pathology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
    Genes Dev 17:3062-74. 2003
    ..These data indicate that Cdc25A turnover is more complex than previously appreciated and suggest roles for an additional kinase(s) in Chk1-dependent Cdc25A turnover...
  15. ncbi Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of I kappa B alpha
    P Tan
    Derald H Ruttenberg Cancer Center, Mount Sinai School of Medicine, New York, New York 10029, USA
    Mol Cell 3:527-33. 1999
    ..protein, is recruited by cullin 1 to form a quatemary SCFHOS-ROC1 holenzyme (with Skp1 and the beta-TRCP homolog HOS)...
  16. pmc Negative regulation of prolactin receptor stability and signaling mediated by SCF(beta-TrCP) E3 ubiquitin ligase
    Ying Li
    Department of Animal Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Mol Cell Biol 24:4038-48. 2004
    ..These data indicate that PRLR is a novel SCF(beta-TrCP) substrate and implicate beta-TrCP as an important negative regulator of PRL signaling and cellular responses to this hormone...
  17. ncbi HOS, a human homolog of Slimb, forms an SCF complex with Skp1 and Cullin1 and targets the phosphorylation-dependent degradation of IkappaB and beta-catenin
    S Y Fuchs
    Derald H Ruttenberg Cancer Center, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Oncogene 18:2039-46. 1999
    ..We identified a human F-box/WD40 repeats protein (HOS), which is homologous to Slimb/h betaTrCP...
  18. ncbi Crystal structure of dimeric heme oxygenase-2 from Synechocystis sp. PCC 6803 in complex with heme
    Masakazu Sugishima
    Department of Biology, Graduate School of Science, Osaka University, Toyonaka, Osaka 560 0043, Japan
    Biochemistry 44:4257-66. 2005
    ..Although heme-Syn HO-2 shares common folding with other HOs, the C-terminal segment is ordered and turns back to the heme-binding side...
  19. doi Carbon monoxide in biology and microbiology: surprising roles for the "Detroit perfume"
    Kelly S Davidge
    Department of Molecular Biology and Biotechnology, The University of Sheffield, Firth Court, Sheffield, UK
    Adv Microb Physiol 56:85-167. 2009
    ..However, CO is also generated endogenously by heme oxygenases (HOs) in mammals and microbes, and its extraordinary biological activities are now recognized and increasingly utilized ..
  20. ncbi Inhibition of growth of human osteosarcomas by antagonists of growth hormone-releasing hormone
    J Pinski
    Endocrine, Polypeptide, and Cancer Institute, Department of Veterans Affairs Medical Center, New Orleans, LA 70146, USA
    J Natl Cancer Inst 87:1787-94. 1995
    ..Recently, we synthesized various potent antagonists of GH-releasing hormone (GH-RH), including [Ibu0, D-Arg2, Phe(4-Cl)6, Abu15, Nle27]hGH-RH(1-28)Agm, which is also called MZ-4-71...
  21. ncbi Heme oxygenases in pregnancy II: HO-2 is downregulated in human pathologic pregnancies
    A C Zenclussen
    Charite, Biomedizinisches Forschungszentrum, Campus Virchow, Humboldt University of Berlin, Germany
    Am J Reprod Immunol 50:66-76. 2003
    ..Here we investigated whether the expression of HO-1 and HO-2 is also reduced at the feto-maternal interface of pathologic human pregnancies...
  22. pmc The Medicare Health Outcomes Survey program: overview, context, and near-term prospects
    Nathaniel Jones
    Maryland Institute for Policy Analysis and Research MIPAR, University of Maryland, Baltimore County UMBC, 1000 Hilltop Circle, Baltimore, MD 21250, USA
    Health Qual Life Outcomes 2:33. 2004
    In 1996, the Centers for Medicare & Medicaid Services (CMS) initiated the Medicare Health Outcomes Survey (HOS)...
  23. ncbi Sperm-preparation techniques for men with normal and abnormal semen analysis. A comparison
    C T Erel
    Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Cerrahpasa School of Medicine, Istanbul University, Istanbul, Turkey
    J Reprod Med 45:917-22. 2000
    ..techniques, density gradient centrifugation and swim-up procedures, with respect to their effects on acrosome reaction (AR), hypoosmotic swelling (HOS) and nuclear maturity in men with abnormal and normal semen analyses.
  24. ncbi Patient desire for information and decision making in health care decisions: the Autonomy Preference Index and the Health Opinion Survey
    R F Nease
    Department of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA
    J Gen Intern Med 10:593-600. 1995
    OBJECTIVES: To compare results on the Autonomy Preference Index (API) and the Health Opinion Survey (HOS), two instruments that measure patient desire for information and involvement in decision making. DESIGN: Cross-sectional survey...
  25. ncbi Activation of mitogen activated protein kinases via complement receptor type 2
    Min Hua Luo
    Institut fur Hygiene, Innsbruck Universität, Fritz Pregl Str sse, A 6010 Innsbruck, Austria
    Chin Med J (Engl) 117:1802-8. 2004
    ....
  26. pmc Multiple heme oxygenase family members contribute to the biosynthesis of the phytochrome chromophore in Arabidopsis
    Thomas J Emborg
    Department of Genetics, University of Wisconsin, Madison, 53706, USA
    Plant Physiol 140:856-68. 2006
    The oxidative cleavage of heme by heme oxygenases (HOs) to form biliverdin IXalpha (BV) is the committed step in the biosynthesis of the phytochrome (phy) chromophore and thus essential for proper photomorphogenesis in plants...
  27. ncbi Vector-based Ape1 small interfering RNA enhances the sensitivity of human osteosarcoma cells to endostatin in vivo
    Dong Wang
    Cancer Center, and Department of Pathology, Daping Hospital and Research Institute of Surgery, Third Military Medical University, Chongqing 400042, China
    Cancer Sci 98:1993-2001. 2007
    ..Transfection of human osteosarcoma 9901 and HOS cells with pSilenceApe1 resulted in a dose-dependent loss of Ape1 protein...
  28. ncbi Acute non-outbreak shigellosis: ten years experience in southern Taiwan
    Chi Hung Wu
    Department of Pediatrics, Chang Gung Memorial Hospital, Chiayi, Taiwan
    Chang Gung Med J 32:59-65. 2009
    ..We conducted a retrospective study of both the clinical and laboratory characteristics of shigellosis in southern Taiwan...
  29. ncbi The potential fertility estimation capacity of the hypoosmotic swelling test, the thermal stress test and a modified cervical mucus penetration test in the bovine
    Suleyman Bacinoglu
    Department of Reproduction and Artificial Insemination, Faculty of Veterinary Medicine, Istanbul University, 34320 Istanbul, Turkey
    Anim Reprod Sci 104:38-46. 2008
    In this study, hypoosmotic swelling (HOS), thermal stress (TS) and modified cervical mucus penetration (mCMP) tests have been used with routine tests for the assessment of semen quality...
  30. ncbi Elevated plasma levels of bilirubin in patients with neurotrauma reflect its pathophysiological role in free radical scavenging
    Kenji Dohi
    Department of Critical Care and Emergency Medicine, Showa University School of Medicine, Tokyo, Japan
    In Vivo 19:855-60. 2005
    Bilirubin, a powerful endogenous antioxidant, is one of the catabolites of heme oxygenases (HOs). In this study, the plasma bilirubin concentration was measured to establish bilirubin kinesis after traumatic brain injury (TBI)...
  31. doi Heme oxygenase 2 of the cyanobacterium Synechocystis sp. PCC 6803 is induced under a microaerobic atmosphere and is required for microaerobic growth at high light intensity
    Mete Yilmaz
    Division of Biology and Medicine, Brown University, Providence, RI 02912, USA
    Photosynth Res 103:47-59. 2010
    ..Light intensity did not have an effect on the expression of both the HOs. Cells, in which ho2 was disrupted, were unable to grow microaerobically at a light intensity of 40 micromol m(-2) ..
  32. ncbi Platinum agents in the treatment of osteosarcoma: efficacy of cisplatin vs. carboplatin in human osteosarcoma cell lines
    H Robson
    Tumour Biochemistry Laboratory, Clinical Research Department, Christie Hospital NHS Trust, Wilmslow Road, Manchester M20 4BX, UK
    Med Pediatr Oncol 39:573-80. 2002
    ..Studies evaluating the role of combination CT containing CBDCA vs. cDDP have demonstrated differing results depending on the tumor type tested and its role in the treatment of osteosarcoma has yet to be clarified...
  33. ncbi Inhibitory effects of antisense cathepsin B cDNA transfection on invasion and motility in a human osteosarcoma cell line
    S Krueger
    Department of Pathology, Otto von Guericke University Magdeburg, Germany
    Cancer Res 59:6010-4. 1999
    ..To investigate the role of cathepsin B in bone tumor invasion, the osteosarcoma cell line MNNG/HOS was stably transfected with an expression vector capable of expressing the antisense cDNA transcript of cathepsin B...
  34. ncbi The hydrogen-bonding network in heme oxygenase also functions as a modulator of enzyme dynamics: chaotic motions upon disrupting the H-bond network in heme oxygenase from Pseudomonas aeruginosa
    Juan Carlos Rodriguez
    Ralph N Adams Institute for Bioanalytical Chemistry and Department of Chemistry, University of Kansas, Multidisciplinary Research Building, 2030 Becker Drive, Room 220 E, Lawrence, Kansas 66047, USA
    J Am Chem Soc 129:11730-42. 2007
    ..state pa-HO shows that residues involved in the network of structural hydrogen-bonded waters characteristic of HOs undergo micros-ms motions in pa-HO-CN, which was studied as a model of the highly paramagnetic S = 5/2 resting ..
  35. ncbi Reactive oxygen species, total antioxidant concentration of seminal plasma and their effect on sperm parameters and outcome of IVF/ICSI patients
    M E Hammadeh
    Department of Obstetrics and Gynaecology, University of Saarlandes, 66421 Homburg Saar, Germany
    Arch Gynecol Obstet 277:515-26. 2008
    ..of IVF (in vitro fertilization) and ICSI patients, to establish their effect on sperm quality (count, vitality, HOS, morphology, maturity, DNA strand breaks) and assess the fertilization potential of spermatozoa and IVF/ICSI outcome...
  36. ncbi Efficacy of the third-generation bisphosphonate risedronate alone and in combination with anticancer drugs against osteosarcoma cell lines
    Takashi Murayama
    Department of Orthopaedic Surgery, Kagoshima Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    Anticancer Res 28:2147-54. 2008
    ..However, the efficacies of BPs against osteosarcoma have not yet been fully elucidated, and the anti-osteosarcoma activity of the potent new-generation BP risedronate, which is widely used clinically, has not been determined...
  37. ncbi Magnetically labeled human natural killer cells, accumulated in vitro by an external magnetic force, are effective against HOS osteosarcoma cells
    Yuko Nakashima
    Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima 734 8551, Japan
    Int J Oncol 27:965-71. 2005
    ..killer (NK) cell delivery system in vitro, and also investigated the antitumor effect of the accumulated cells on HOS osteosarcoma cells...
  38. ncbi Effect of interesterification of palmitic acid-rich triacylglycerol on postprandial lipid and factor VII response
    Sarah E E Berry
    Department of Nutrition and Dietetics, Nutritional Sciences Research Division, King s College London, Franklin Wilkins Building, 150 Stamford Street, London, SE1 9NH, UK
    Lipids 42:315-23. 2007
    ..g fat [interesterified palm oil (IPO) versus native palm oil (NPO); n=20, and IPO versus high-oleic sunflower oil (HOS); n=18], on postprandial changes in lipids, glucose, insulin, chylomicron composition and FVIIa...
  39. pmc Spectroscopic insights into axial ligation and active-site H-bonding in substrate-bound human heme oxygenase-2
    Jessica D Gardner
    Department of Chemistry, University of Wisconsin Madison, 1101 University Ave, Madison, WI 53706, USA
    J Biol Inorg Chem 15:1117-27. 2010
    Heme oxygenases (HOs) are monooxygenases that catalyze the first step in heme degradation, converting heme to biliverdin with concomitant release of Fe(II) and CO from the porphyrin macrocycle...
  40. pmc Human T-cell leukemia virus type 1 infection leads to arrest in the G1 phase of the cell cycle
    Meihong Liu
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    J Virol 82:8442-55. 2008
    ..In contrast, cells of a human osteosarcoma lineage (HOS) continued to divide after HTLV-1 infection or Tax expression, albeit at a reduced growth rate and with mitotic ..
  41. doi Causes and management of a high-output stoma
    M L Baker
    Nutrition Support Team, Department of Dietetics, Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, Leicester, UK
    Colorectal Dis 13:191-7. 2011
    Patients with a high-output stoma (HOS) (> 2000 ml/day) suffer from dehydration, hypomagnesaemia and under-nutrition. This study aimed to determine the incidence, aetiology and outcome of HOS.
  42. ncbi The effect of colloid osmotic pressure in human spermatozoa exposed to hypoosmotic conditions
    J R Correa-Perez
    Centro de Fertilidad del Caribe, Torre San Francisco Suite 606, 3659 Ave de Diego, Rio Piedras, Puerto Rico 00923
    Andrologia 35:117-20. 2003
    ..A stock hypoosmotic solution (HOS) was prepared by using a mixture of fructose and sodium citrate and adjusted to an osmotic pressure of 150 mOsm l-1...
  43. doi Initial report from the Hunter Outcome Survey
    J Edmond Wraith
    From the 1Willink Biochemical Genetics Unit, Royal Manchester Children s Hospital, Manchester, United Kingdom
    Genet Med 10:508-16. 2008
    ..The Hunter Outcome Survey (HOS) was established to better describe the natural history of this disorder and to evaluate the long-term effect of ..
  44. doi Heme oxygenase-1 and neurodegeneration: expanding frontiers of engagement
    Hyman M Schipper
    Centre for Neurotranslational Research, Lady Davis Institute for Medical Research, Jewish General Hospital, Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada
    J Neurochem 110:469-85. 2009
    The heme oxygenases (HOs), responsible for the degradation of heme to biliverdin/bilirubin, free iron and CO, have been heavily implicated in mammalian CNS aging and disease...
  45. ncbi Chemokine receptor CXCR4-beta1 integrin axis mediates tumorigenesis of osteosarcoma HOS cells
    Kohei Miura
    BioTherapeutics Research Group, Robarts Research Institute and Department of Microbiology and Immunology, University of Western Ontario, London, ON N6A 5K8, Canada
    Biochem Cell Biol 83:36-48. 2005
    ..In the present study, the beta1 integrin-chemokine axis is assessed using human osteosarcoma (HOS) transfectant cells expressing the CXCR4 receptor for chemokine SDF-1 (CXCL12)...
  46. ncbi Geriatrics attitudes and knowledge among surgical and medical subspecialty house officers
    Lewis P Krain
    Department of Psychiatry, Ann Arbor Veterans Affairs Medical Center, University of Michigan, Ann Arbor, Michigan, USA
    J Am Geriatr Soc 55:2056-60. 2007
    To examine geriatrics knowledge and attitudes of non-primary care house officers (HOs) before and after a multidisciplinary faculty development program.
  47. ncbi [The role of CD44 in the proliferation, adhesiveness and invasiveness of osteosarcoma cell lines]
    Ting Sheng Peng
    Department of Pathology, Sun Yat sen Medical College, Sun Yat Sen University, Guangzhou 510080, China
    Zhonghua Bing Li Xue Za Zhi 34:362-6. 2005
    ..To study the influence of CD44 a cell-matrix adhesion molecule on the proliferation, adhesiveness and invasiveness of osteosarcoma cell lines, in order to investigate the growth and invasion mechanism of osteosarcoma...
  48. ncbi A quantitative immunochemical faecal occult blood test is more efficient for detecting significant colorectal neoplasia than a sensitive guaiac test
    Z Levi
    Department of Gastroenterology, Rabin Medical Center, Beilinson Hospital, Petach Tikva, Israel
    Aliment Pharmacol Ther 23:1359-64. 2006
    The sensitive guaiac faecal occult blood test, Haemoccult SENSA (HOS; Beckman Coulter, Fullerton, CA, USA), is our standard screening test for significant colorectal neoplasia...
  49. doi Prognostic value of various spermatological attributes as predictors of zona binding and zona penetration of buffalo (Bubalus bubalis) semen
    S Selvaraju
    Reproductive Physiology Laboratory, Animal Physiology Division, National Institute of Animal Nutrition and Physiology, Bangalore, India
    Reprod Domest Anim 44:6-11. 2009
    ..05) was observed between the plasmalemma integrity as assessed by eosin--nigrosin stain and hypo-osmotic swelling (HOS) test. Furthermore, the percentage of cells positive for the HOS test, i.e. functional membrane integrity (51...
  50. ncbi Progesterone receptor as an indicator of sperm function
    Sushama Gadkar
    Institute for Research in Reproduction, Indian Council of Medical Research, Parel, Mumbai 400 012, India
    Biol Reprod 67:1327-36. 2002
    ..n = 9), and teratozoospermia (n = 10) were exposed to low osmotic conditions in the hypoosmotic swelling (HOS) test and then analyzed for PR expression using P-FITC-BSA complex. A significantly higher percentage (P < 0...
  51. ncbi Functionally significant mutations in the Epstein-Barr virus LMP1 gene and their role in activation of cell signaling pathways
    S V Diduk
    Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Moscow, 115478, Russia
    Biochemistry (Mosc) 73:1134-9. 2008
    ..motifs within LMP1 are responsible for interaction of this viral protein with the receptor protein beta-TrCP/HOS SCF of the ubiquitin ligase E3 complex, playing an important role in degradation of numerous cellular proteins ..
  52. ncbi [Effects of the extracts of Cajanus cajan L. on cell functions in human osteoblast-like TE85 cells and the derivation of osteoclast-like cells]
    Yuan yuan Zheng
    Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China
    Yao Xue Xue Bao 42:386-91. 2007
    ..32-1, 35-1, 35-2, and 35-3) were tested in human osteoblast-like (HOS) TE85 cells and marrow-derived osteoclast-like cells...
  53. ncbi Comparative analysis of results of guaiac and immunochemical tests for faecal occult blood in colorectal cancer screening in two oncological institutions
    G Castiglione
    Centro per lo Studio e la Prevenzione Oncologica, Florence, Italy
    Eur J Cancer Prev 3:399-405. 1994
    The performances of three faecal occult blood tests, rehydrated Hemoccult (HOR), Hemoccult sensa (HOS) and Hemeselect (HSEL) on 3 days were compared in 1,725 subjects consecutively recruited in two oncological institutions in Milan and ..
  54. ncbi Functional imaging of multidrug resistance in an orthotopic model of osteosarcoma using 99mTc-sestamibi
    Célia M F Gomes
    Department of Radiology, Section of Nuclear Medicine, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Nucl Med Mol Imaging 34:1793-803. 2007
    ..The purpose of this work was the development of an orthotopic model of osteosarcoma based on luciferase-expressing tumour cells for the in vivo imaging of multidrug resistance (MDR) with (99m)Tc-sestamibi...
  55. doi Is abnormal sperm function an indicator among couples with recurrent pregnancy loss?
    Pikee Saxena
    National Institute of Health and Family Welfare, Baba Gang Nath Marg, Munirka, New Delhi, India
    Fertil Steril 90:1854-8. 2008
    ..To determine whether or not sperm function parameters are altered in male partners of couples with a history of idiopathic recurrent pregnancy loss (RPL)...
  56. ncbi Expression of estrogen receptors alfa and beta mRNA and alkaline phosphatase in the differentiation of osteoblasts from elderly postmenopausal women: comparison with osteoblasts from osteosarcoma cell lines
    Fang Ping Chen
    Department of Obstetrics and Gynecology, Keelung Chang Gung Memorial Hospital and Chang Gung University, Keelung, Taiwan
    Taiwan J Obstet Gynecol 45:307-12. 2006
    ..the expression of estrogen receptors (ER) alpha and beta, and activity of alkaline phosphatase during differentiation of primary osteoblast cells (hOB) from aged postmenopausal women and human osteosarcoma cell lines (HOS, MG63).
  57. ncbi Synthesis and secretion of plasminogen activators and collagenases in human cells transformed by Kirsten murine sarcoma virus and N-methyl-N'-nitro-N-nitrosoguanidine
    M K Sidhu
    Department of Biochemistry and Molecular Biology, UMDNJ New Jersey Medical School, Newark 07103
    Cancer Lett 47:45-51. 1989
    ..levels of plasminogen activators and collagenases have been examined in the nonmalignant human osteosarcoma (HOS), the malignant Kirsten murine sarcoma virus transformed (KHOS/NP), the temperature sensitive revertant of virus ..
  58. ncbi Diverse mechanisms of osteoblast spreading on hydroxyapatite and titanium
    T Matsuura
    Dental Research Center, University of North Carolina at Chapel Hill, 27599 7450, USA
    Biomaterials 21:1121-7. 2000
    ..We previously demonstrated that RGD peptides regulate the spreading of HOS cells on HA but not on titanium, speculating that the osteoconductivity of HA might be attributed to this RGD ..
  59. ncbi Evidence of validity for the hip outcome score in hip arthroscopy
    Robroy L Martin
    Duquesne University, Center for Sports Medicine, University of Pittsburgh Medical Center corrected Pittsburgh, Pennsylvania 15282, USA
    Arthroscopy 23:822-6. 2007
    The purpose of this study was to provide evidence of validity for the Hip Outcome Score (HOS) as an outcome instrument in hip arthroscopy.
  60. ncbi Shedding of the interleukin-6 (IL-6) receptor (gp80) determines the ability of IL-6 to induce gp130 phosphorylation in human osteoblasts
    Csaba Vermes
    Department of Orthopedic Surgery, Rush University, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
    J Biol Chem 277:16879-87. 2002
    ..Three different human osteoblast-like cell lines (MG-63, HOS, and SaOS-2) and bone marrow-derived primary human osteoblasts expressed both IL-6R and gp130 as determined by flow ..
  61. ncbi [Evaluation of corneal tissue processed by a reference Eye Bank]
    Reinaldo Ferreira da Silva
    Hospital Oftalmológico de Sorocaba, Sorocaba, SP, Brasil
    Arq Bras Oftalmol 72:673-6. 2009
    ..corneas processed by Sorocaba Eye Bank (BOS) - SP and transplanted out of the Ophthalmology Hospital of Sorocaba (HOS), as well as the corneas that had re-entered in the BOS, being transplanted or not in the HOS, during the year of ..
  62. doi The effects of intravenous hyperoxygenated solution infusion on systemic oxygenation and intrapulmonary shunt during one-lung ventilation in pigs
    Changjun Gao
    Department of Anesthesiology, Tangdu Hospital, Fourth Military Medical University, Xi an, Shaanxi Province, China
    J Surg Res 159:653-9. 2010
    ..The aim of this study was to investigate whether intravenous hyperoxygenated solution (HOS) infusion would improve systemic oxygenation and reduce intrapulmonary shunt during OLV.
  63. doi Acid-, water- and high-temperature-stable ruthenium complexes for the total catalytic deoxygenation of glycerol to propane
    Deeb Taher
    Chemistry Department, Tafila Technical University, P O Box 179, Tafila 66110, Jordan
    Chemistry 15:10132-43. 2009
    ..In the presence of HOS(O)(2)CF(3) (triflic acid) as a dehydration co-catalyst they directly convert 1,2-hexanediol to n-hexanol and hexane...
  64. ncbi Nerve growth factor induces anti-apoptotic heme oxygenase-1 in rat pheochromocytoma PC12 cells
    Heling Liu
    Cardiovascular Research Center of the Department of Medicine, Harvard Medical School, Charlestown, Massachusetts, USA
    J Neurochem 86:1553-63. 2003
    Nerve growth factor (NGF) and heme oxygenases (HOs) both exert neuroprotective effects...
  65. doi Mortality and cause of death in mucopolysaccharidosis type II-a historical review based on data from the Hunter Outcome Survey (HOS)
    S A Jones
    Willink Unit, Genetic Medicine, Manchester Academic Health Science Centre, Central Manchester University Hospitals, NHS Foundation Trust, St Mary s Hospital, Manchester, UK
    J Inherit Metab Dis 32:534-43. 2009
    ..period in which patients died with age at death in 129 patients for whom data were entered retrospectively into HOS (Hunter Outcome Survey), the only large-scale, multinational observational study of patients with MPS II...
  66. ncbi sall4 acts downstream of tbx5 and is required for pectoral fin outgrowth
    Steven A Harvey
    Division of Developmental Biology, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
    Development 133:1165-73. 2006
    ..Mutations in the T-box transcription factor TBX5 cause Holt-Oram syndrome (HOS), which results in forelimb and heart defects...
  67. ncbi High energy shock waves enhance the cytotoxic effect of doxorubicin and methotrexate to human osteosarcoma cell lines
    Alessandra Palmero
    Department of Paediatrics, Regina Margherita Children s Hospital, University of Turin, Italy
    Oncol Rep 15:267-73. 2006
    ..The effect of these combinations on SJSA-1, MG-63 and HOS human osteosarcoma cell lines were evaluated through incubation with doxorubicin or methotrexate and high energy ..
  68. ncbi Curcumin induces cell cycle arrest and apoptosis in human osteosarcoma (HOS) cells
    Duk Su Lee
    Department of Biochemistry, School of Dentistry, Kyung Hee University, 1 Hoeki dong, Dongdaemoon Ku, Seoul 130 701, Korea
    Anticancer Res 29:5039-44. 2009
    ..In this study, we showed that curcumin induced cell cycle arrest followed by antiproliferation and apoptosis in human osteosarcoma (HOS) cells.
  69. pmc HO1 mRNA and Protein do not Change in Parallel in Bronchial Biopsies of Patients After Long Term Exposure to Sulfur Mustard
    Mohammad Reza Nourani
    Chemical Injury Research Center CIRC, Baqiyatallah Medical Sciences University, Tehran, Iran
    Gene Regul Syst Bio 4:83-90. 2009
    ..SM causes the endogenous production of reactive oxygen species (ROS).Heme oxygenases (HOs) are the rate-limiting enzyme for heme metabolism...
  70. pmc Effects of the crude extract of Polygala tenuifolia Willd on human sperm in vitro
    Yi Qiu
    Key Laboratory for Improving Birth Outcome Technique, Shandong Provincial Institute of Science and Technology for Family Planning, Jinan 250002, China
    J Zhejiang Univ Sci B 12:448-54. 2011
    ..The hypo-osmotic swelling (HOS) test and the eosin Y (EY) staining were used to detect the integrity of sperm membrane and vitality...
  71. pmc Beta4 integrin promotes osteosarcoma metastasis and interacts with ezrin
    X Wan
    Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892 1928, USA
    Oncogene 28:3401-11. 2009
    ..Furthermore, highly metastatic MNNG-HOS cells have increased levels of beta4 integrin...
  72. doi Experimental studies on the bone metabolism of male rats chronically exposed to cadmium intoxication using dual-energy X-ray absorptiometry
    H Yokota
    Department of Radiology, Kanazawa Medical University, Uchinada, Kahoku, Ishikawa, Japan
    Toxicol Ind Health 24:161-70. 2008
    ..Six-week-old male Hos Donryu rats were used in this experiment...
  73. doi Dual programmed cell death pathways induced by p53 transactivation overcome resistance to oncolytic adenovirus in human osteosarcoma cells
    Joe Hasei
    Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Mol Cancer Ther 12:314-25. 2013
    ..The cytopathic activity of OBP-702 was examined in OBP-301-sensitive (U2OS and HOS) and OBP-301-resistant (SaOS-2 and MNNG/HOS) human osteosarcoma cells...
  74. pmc TBX5 intragenic duplication: a family with an atypical Holt-Oram syndrome phenotype
    Chirag Patel
    Department of Clinical Genetics, Birmingham Women s NHS Foundation Trust, Birmingham, UK
    Eur J Hum Genet 20:863-9. 2012
    Holt-Oram syndrome (HOS) is a rare autosomal dominant heart-hand syndrome due to mutations in the TBX5 transcription factor...
  75. doi Assessment of higher order structure comparability in therapeutic proteins using nuclear magnetic resonance spectroscopy
    Carlos A Amezcua
    Baxter Healthcare Corporation, Round Lake, Illinois 60073, USA
    J Pharm Sci 102:1724-33. 2013
    In this work, we applied nuclear magnetic resonance (NMR) spectroscopy to rapidly assess higher order structure (HOS) comparability in protein samples. Using a variation of the NMR fingerprinting approach described by Panjwani et al...
  76. pmc β-TrCP-mediated IRAK1 degradation releases TAK1-TRAF6 from the membrane to the cytosol for TAK1-dependent NF-κB activation
    Wei Cui
    State Key Laboratory of Protein and Plant Gene Research, LSC, Peking University, Beijing, China
    Mol Cell Biol 32:3990-4000. 2012
    ..Taken together, these results implicate a positive role of β-TrCP-mediated IRAK1 degradation in IL-1-induced TAK1 activation...
  77. pmc Modulation of u-PA, MMPs and their inhibitors by a novel nutrient mixture in pediatric human sarcoma cell lines
    M Waheed Roomi
    Dr Rath Research Institute, Santa Clara, CA, USA
    Int J Oncol 43:1027-35. 2013
    ..Human osteosarcoma MNNG-HOS, osteosarcoma U-2OS and rhabdomyosarcoma RD cell lines (ATCC) were cultured in their respective media and treated ..
  78. ncbi Arsenite induces delayed mutagenesis and transformation in human osteosarcoma cells at extremely low concentrations
    Kanae Mure
    New York University School of Medicine, Nelson Institute of Environmental Medicine, Tuxedo, New York 10987, USA
    Environ Mol Mutagen 41:322-31. 2003
    ..1 microM) of arsenite transform human osteosarcoma TE85 (HOS) cells to anchorage-independence...
  79. pmc Role of cholesterol in human immunodeficiency virus type 1 envelope protein-mediated fusion with host cells
    Mathias Viard
    Laboratory of Experimental and Computational Biology, Center for Cancer Research, National Cancer Institute Frederick, National Institutes of Health, Frederick, Maryland 21702, USA
    J Virol 76:11584-95. 2002
    ..However, treatment of human osteosarcoma (HOS) cells expressing high levels of CD4 and coreceptors with these agents did not affect their susceptibility to HIV-1 ..
  80. ncbi Altered renal sodium handling in spontaneously hypertensive rats (SHR) after hypertonic saline intracerebroventricular injection: role of renal nerves
    Dioze Guadagnini
    Disciplina de Medicina Interna, Laboratório de Metabolismo Hidro Salino, Nucleo de Medicina e Cirurgia Experimental, Departamento de Clinica Medica, Faculdade de Ciencias Medicas, Universidade Estadual de Campinas, 13083 100 Campinas, SP, Brazil
    Life Sci 79:1666-73. 2006
    ..data on the natriuretic mechanisms induced by intracerebroventricular (ICV) injection of hyperosmotic saline (HoS) in SHR...
  81. ncbi Revision of hypo-osmotic swelling (HOS) test with a proposition of classified grading system: its comparisons with four different types of human sperm separation technique
    F N Wang
    Department of Obstetrics and Gynecology, King Drew Medical Center, Charles R Drew University of Medicine and Sciences, Los Angeles, California 90059, USA
    Arch Androl 51:317-26. 2005
    ..was SG 0 > SG 1 > SG 3 > SG2 > SG 0-R in fresh semen, and the proportion of SG 0 was almost half of the total % HOS test results...
  82. ncbi Improving the predictive value of the hypoosmotic swelling test in humans
    Ana C Martini
    Instituto de Fisiologia, Facultad de Ciencias Medicas, Universidad Nacional de Cordoba, Cordoba, Argentina
    Fertil Steril 85:1840-2. 2006
    Using a combined hypoosmotic swelling-eosin (HOS-E) technique in human semen samples, we evaluated the frequency of dead swollen spermatozoa (dHOS) after 10 and 30 minutes of incubation, the correlation between total HOS-reactive (tHOS) ..
  83. doi The Renner Effect in the X̃ (2)A″ and à (2)A' Electronic States of HSO/HOS
    Roman I Ovsyannikov
    FB C Physikalische und Theoretische Chemie, Bergische Universitat, D 42097 Wuppertal, Germany
    J Phys Chem A 117:13450-64. 2013
    We report a theoretical investigation of the X̃ (2)A″ and à (2)A' electronic states of HSO/HOS. Three-dimensional potential energy surfaces for the X̃ (2)A″ and à (2)A' electronic states of HSO/HOS have been calculated ab initio ..
  84. pmc LMP1 strain variants: biological and molecular properties
    Bernardo A Mainou
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Virol 80:6458-68. 2006
    ..These findings indicate that the signature amino acid changes of the LMP1 variants do not hinder or enhance their in vitro transforming potentials or affect their signaling properties...
  85. ncbi Three novel TBX5 mutations in Chinese patients with Holt-Oram syndrome
    J Yang
    Department of Cardiothoracic Surgery, The Second Affiliated Hospital, Hunan Medical University, Changsha, China
    Am J Med Genet 92:237-40. 2000
    Holt-Oram syndrome (HOS) is an autosomal dominant syndrome that comprises upper limb and cardiac defects. The gene responsible for HOS, TBX5, was isolated and many mutations have been identified in HOS patients...
  86. doi Association of Health Plans' Healthcare Effectiveness Data and Information Set (HEDIS) performance with outcomes of enrollees with diabetes
    Jeffrey S Harman
    Department of Health Services Research, Management and Policy, College of Public Health and Health Professions, University of Florida, Gainesville, FL, USA
    Med Care 48:217-23. 2010
    ..Few quality of care evaluations examine the relationship between clinical processes and patient outcomes...
  87. ncbi Observation of radiation-specific damage in human cells exposed to depleted uranium: dicentric frequency and neoplastic transformation as endpoints
    A C Miller
    Applied Cellular Radiobiology Department, Armed Forces Radiobiology Research Institute, Bethesda, MD 20889 5603, USA
    Radiat Prot Dosimetry 99:275-8. 2002
    ..data from our laboratory have demonstrated that DU exposure in vitro to immortalised human osteoblast cells (HOS) is both neoplastically transforming and genotoxic...
  88. ncbi [Bilateral internal jugular thrombosis associated with thrombophilia after ovarian induction for infertility]
    Fernando Vazquez
    Servicio de Clinica Medica, Hospital Italiano de Buenos Aires, Gascon 450, 1181 Buenos Aires, Argentina
    Medicina (B Aires) 62:328-30. 2002
    ..of hormonal treatment for infertility and are generally related to the hyperstimulated ovarian syndrome (HOS)...
  89. ncbi Overexpression of integrin alphav promotes human osteosarcoma cell populated collagen lattice contraction and cell migration
    Howard Levinson
    Division of Plastic Surgery, M S Hershey Medical Center, Hershey, Pennsylvania 17033, USA
    J Cell Physiol 193:219-24. 2002
    ..To elucidate alphav integrins' effects on cell-collagen interactions, human osteosarcoma (HOS) cells were transfected with alphav integrin (alphav-pcDNA 3.1+). Control HOS cells were transfected with pcDNA 3...
  90. ncbi Sperm-lectin agglutination combined with swim-up leads to an efficient selection of highly motile, viable and heterogeneous ram spermatozoa
    R Perez-Pe
    Departamento de Bioquimica y Biologia Molecular y Celular, Facultad de Veterinaria, Zaragoza, Spain
    Theriogenology 51:623-36. 1999
    ..To study sperm quality, cell viability (plasma membrane integrity), the HOS-test response and progressive individual motility were assessed...
  91. pmc Isocyanides inhibit human heme oxygenases at the verdoheme stage
    John P Evans
    Department of Pharmaceutical Chemistry, University of California, 600 16th Street, San Francisco, California 94158 2517, USA
    Biochemistry 48:8920-8. 2009
    ..hHO-1) is overexpressed in tumor tissues, where it helps to protect cancer cells from anticancer agents, while HOs in fungal pathogens, such as Candida albicans, function as the primary means of iron acquisition...
  92. ncbi Membrane changes during different stages of a freeze-thaw protocol for equine semen cryopreservation
    Deborah M Neild
    Area de teriogenologia, Departamento de Medicina, Facultad de Ciencias Veterinarias, Universidad de Buenos Aires, Chorroarin 280, Capital Federal 1427, Argentina
    Theriogenology 59:1693-705. 2003
    ..Membrane function was evaluated using the hypo-osmotic swelling test (HOS) and progressive motility (PM) was evaluated under light microscopy at each stage of a freeze-thaw protocol...
  93. ncbi fau and its ubiquitin-like domain (FUBI) transforms human osteogenic sarcoma (HOS) cells to anchorage-independence
    Toby G Rossman
    The Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo 10987, USA
    Oncogene 22:1817-21. 2003
    ..We intended to test its ability to block arsenite-induced transformation of human osteogenic sarcoma (HOS) cells to anchorage-independence. Instead, we found that overexpressing fau itself was able to transform HOS cells...
  94. ncbi Heme oxygenase and angiogenic activity of endothelial cells: stimulation by carbon monoxide and inhibition by tin protoporphyrin-IX
    Alicja Jozkowicz
    Department of Vascular Surgery, University of Vienna, Austria
    Antioxid Redox Signal 5:155-62. 2003
    The activity of heme oxygenase enzymes (HOs) is responsible for the endogenous source of carbon monoxide (CO). Their activities can be inhibited by tin protoporphyrin-IX (SnPPIX)...
  95. ncbi Seasonal changes in semen quality and freezability in the Warmblood stallion
    F Janett
    Clinic of Reproduction, University of Zurich, Winterthurerstrasse 260, 8057 Zurich, Switzerland
    Theriogenology 60:453-61. 2003
    ..semen samples motility as well as viability (SYBR-14/PI) was tested, and the hypoosmotic swelling test (HOS) was performed...
  96. ncbi Triggering of p73-dependent apoptosis in osteosarcoma is under the control of E2Fs-pRb2/p130 complexes
    Dario La Sala
    ITOI CNR, Unit of Bologna, c o IOR, 40136 Bologna, Italy
    Oncogene 22:3518-29. 2003
    ..We selected the osteosarcoma MDR HosDXR150 cell line by culturing Hos cells in the presence of increasing doxorubicin doses and showed that it is crossresistant to vinblastine...
  97. pmc Morphologic characterization of osteosarcoma growth on the chick chorioallantoic membrane
    Maurice Balke
    Department of Orthopaedic Surgery, University of Muenster, Muenster, Germany
    BMC Res Notes 3:58. 2010
    ..We therefore screened eight osteosarcoma cell lines for their ability to form vascularized tumours on the CAM...
  98. doi In vitro osteogenic differentiation of HOS cells on two types of collagen gels
    Takako Takitoh
    Department of Biological Science, Graduate School of Science, Osaka Prefecture University, 1 2 Gakuen cho, Naka ku, Sakai, Osaka 599 8570, Japan
    J Biosci Bioeng 110:471-8. 2010
    b>HOS cell is a model strain of human osteoblasts derived from human osteosarcoma. We cultured the HOS cells on both the conventional collagen gel (neutral gel), and the gamma-crosslinked collagen gel without collagen fibrils (acidic gel)...
  99. doi The rapid anastomosis between prevascularized networks on silk fibroin scaffolds generated in vitro with cocultures of human microvascular endothelial and osteoblast cells and the host vasculature
    Ronald E Unger
    Institute of Pathology, REPAIR Lab, Johannes Gutenberg University, Langenbeckstrasse 1, Mainz, Germany
    Biomaterials 31:6959-67. 2010
    ..We have previously shown that human microcapillary endothelial cells (HDMEC) and primary human osteoblast cells (HOS) in coculture on various 3-D bone biomaterial scaffolds rapidly distribute and self-assemble into a morphological ..
  100. ncbi Health outcomes. New quality measure for Medicare
    J K Cooper
    Health Care Financing Administration, Baltimore, MD 21244 1850, USA
    Int J Qual Health Care 13:9-16. 2001
    ..A new measurement of health care quality for Medicare beneficiaries has been implemented by the Health Care Financing Administration (HCFA). This paper describes the program, presents baseline data and highlights associated issues...
  101. ncbi Automatic detection of epileptic EEG signals using higher order cumulant features
    U Rajendra Acharya
    Department of Electronics and Computer Engineering, Ngee Ann Polytechnic, Singapore 599489, Singapore
    Int J Neural Syst 21:403-14. 2011
    ..Because of the nonlinear and dynamic nature of EEG signals, the use of nonlinear Higher Order Spectra (HOS) features is a seemingly promising approach...

Research Grants64

  1. Cell Cycle Regulation and Adult T Cell Leukemia
    Chou Zen Giam; Fiscal Year: 2010
    ..By contrast, cells deficient in p21 and p27, such as HOS, escape Tax-IRS and continue to divide after HTLV-1 infection or Tax expression...
  2. HTLV-I Tax activates the anaphase promoting complex
    Chou Zen Giam; Fiscal Year: 2010
    ..By contrast, cells deficient in p21 and p27, such as HOS, escaped Tax- IRS and continue to divide after HTLV-1 infection or Tax expression...
  3. HEMOPROTEIN OXIDATION AND HEME CATABOLISM
    Paul R Ortiz de Montellano; Fiscal Year: 2010
    Heme oxygenases (HOs) oxidize heme to biliverdin, iron, and carbon monoxide (CO) via a complex, three-stage process that requires seven electrons and three molecules of O2...
  4. Electronic/Molecular Structure of Enzyme Heme Pockets
    GERD LA MAR; Fiscal Year: 2007
    ..We select 3 HOs, isozyme #1 from human, hHO, and those from 2 pathogenic bacteria C. diphtheriae (CofHO) and N...
  5. Electronic/Molecular Structure of Enzyme Heme Pockets
    GERD LA MAR; Fiscal Year: 2009
    ..We select three HOs, ispzyme #1 from human, hHO, and those from two pathogenic bacteria C. diphtheriae (CofHO) and N...
  6. Core--Virus Production and Neutralization Facility
    Peng Zhang; Fiscal Year: 2002
    ..luc.R.-E-reporter genome. Neutralization assays will be conducted in microtiter in HOS-CD4-CCR5 or HOS-CD4-CXCR4 cells, using luminescence as the endpoint readout...
  7. Studies on ROC1-dependent Ubiquitin E3 Ligases
    Zhen Qiang Pan; Fiscal Year: 2006
    ..that ROC1-CUL1 functions as a core ubiquitin ligase and is recruited by an adapter, Skpl, and an F-box protein, HOS (beta-TRCP homologue), to form a four-subunit SCFHos/beta-Trcp-ROC1 complex that initiates and catalyzes the ..
  8. MECHANISMS OF INDUCTION OF SKIN CANCERS BY UV LIGHT
    HONNAVARA ANANTHASWAMY; Fiscal Year: 1990
    ..transformation by DNA-mediated gene transfer into 3 recipient cell systems, NIH 3T3, C3H 10T1/2, and human HOS cells...
  9. The role of Lmp4 in the regulation of the cardiac transcription factor Tbx5
    Hans Georg Simon; Fiscal Year: 2009
    ..in a variety of cardiac lineages and structures, and mutations in human TBX5 result in Holt-Oram syndrome (HOS), a disease characterized by congenital heart and limb defects...
  10. The role of Lmp4 in the regulation of the cardiac transcription factor Tbx5
    Hans Georg Simon; Fiscal Year: 2010
    ..in a variety of cardiac lineages and structures, and mutations in human TBX5 result in Holt-Oram syndrome (HOS), a disease characterized by congenital heart and limb defects...
  11. The Genetics of Vulnerability to Nicotine Addictions
    Pamela Madden; Fiscal Year: 2007
    ..identified a strong linkage signal in both Australian and Finnish subsamples for our primary heaviness-of-smoking (HoS) phenotype, on Chr 22 (combined single-point LOD 5.2, genome-wide significance, p=0.003)...
  12. TBX5 and cardiac proliferation
    FRANK LEO CONLON; Fiscal Year: 2010
    ..the Xenopus T-box gene Tbx5, the gene mutated in the human congenital heart disease Holt Oram syndrome (HOS)...
  13. DETERMINATION OF NEURONAL FATES IN VISUAL CORTEX
    Susan McConnell; Fiscal Year: 1993
    ..5 and 6 will be challenged to alter thei normal fates by heterochronic transplantion into the brains of neonatal hos ferrets...
  14. CARCINOGENESIS OF ENVIRONMENTALLY RELEVANT NI COMPOUNDS
    Max Costa; Fiscal Year: 2000
    ..4) To investigate the consequence of inhibiting and activating DNA methylation on HOS cell transformation alone or the transformed state as induced by Ni, as well as other carcinogens.
  15. NEURAL COMPUTATIONS IN VISUAL CORTEX
    Jonathan D Victor; Fiscal Year: 2010
    ..implies that V1 neurons are sensitive to these distinguishing characteristics, namely, high-order statistics (HOS's)...
  16. Role of HOS in cell transformation and apoptosis
    SERGE FUCHS; Fiscal Year: 2009
    ..of a number of important regulators of cell growth, transformation and survival is controlled by the SCF(HOS/beta-Trcp) E3 ubiquitin ligases in a phosphorylation-dependent manner...
  17. Role of HOS in cell transformation and apoptosis
    SERGE FUCHS; Fiscal Year: 2007
    ..Proteolysis of a number of important regulators of cell growth, transformation and survival is controlled by the SCF(HOS/beta-Trcp) E3 ubiquitin ligases in a phosphorylation-dependent manner...
  18. Role of HOS in cell transformation and apoptosis
    SERGE FUCHS; Fiscal Year: 2004
    In studying the mechanisms of targeting proteins for ubiquitination, Dr. Fuks identified HOS, a human homologue of Drosophila Slimb protein, as a key factor in recruitment of SCF E3 ubiquitin ligase to phosphorylated substrates ..
  19. Requirements for the FGF/MAPK in early heart development
    Frank Conlon; Fiscal Year: 2007
    ..A second example is the Holt-Oram syndrome (HOS), a disease associated with mutations in the coding region of the transcription factor TBX5...
  20. A Genetic Approach to Organogenesis in Xenopus
    Frank Conlon; Fiscal Year: 2006
    ..A second example is Holt-Oram syndrome (HOS), a disease often associated with mutations in the coding region of the transcription factor TBX5, a gene also ..
  21. The Genetics of Vulnerability to Nicotine Addictions
    Pamela Madden; Fiscal Year: 2009
    ..identified a strong linkage signal in both Australian and Finnish sibships, for our primary heaviness-of-smoking (HoS) phenotype, on Chr 22q12 (in updated analyses, multi-point LODs of 3.05 and 3.21 respectively)...
  22. The Genetics of Vulnerability to Nicotine Addictions
    PAMELA ANN MADDEN; Fiscal Year: 2010
    ..identified a strong linkage signal in both Australian and Finnish sibships, for our primary heaviness-of-smoking (HoS) phenotype, on Chr 22q12 (in updated analyses, multi-point LODs of 3.05 and 3.21 respectively)...
  23. Tbx5 Protein Networks And Heart/Limb Development Defects
    Hans Georg Simon; Fiscal Year: 2004
    ..A reduced level of Tbx5 protein causes Holt-Oram syndrome (HOS), a disease characterized by developmental defects of the upper limbs and heart septation...
  24. REGULATION OF HEART CHAMBER FORMATION BY TBX5
    Katherine Yutzey; Fiscal Year: 2005
    ..Mutations in the TBX5 have been identified in families with Holt-Oram Syndrome (HOS) which includes atrial septal defects and other cardiac anomalies...