FBXO21

Summary

Gene Symbol: FBXO21
Description: F-box protein 21
Alias: FBX21, F-box only protein 21
Species: human
Products:     FBXO21

Top Publications

  1. Watanabe K, Yumimoto K, Nakayama K. FBXO21 mediates the ubiquitylation and proteasomal degradation of EID1. Genes Cells. 2015;20:667-74 pubmed publisher
    ..We have now applied this approach to an uncharacterized human F-box protein, FBXO21, which serves as the substrate-recognition subunit of a SKP1-CUL1-F-box protein (SCF)-type E3, thereby identifying ..
  2. Zhang C, Li X, Adelmant G, Dobbins J, Geisen C, Oser M, et al. Peptidic degron in EID1 is recognized by an SCF E3 ligase complex containing the orphan F-box protein FBXO21. Proc Natl Acad Sci U S A. 2015;112:15372-7 pubmed publisher
    ..by an Skp1, Cullin, and F-box (SCF)-containing ubiquitin ligase complex that uses the F-box Only Protein 21 (FBXO21) as its substrate recognition subunit...
  3. Ravindranath A, Kaur S, Wernyj R, Kumaran M, Miletti González K, Chan R, et al. CD44 promotes multi-drug resistance by protecting P-glycoprotein from FBXO21-mediated ubiquitination. Oncotarget. 2015;6:26308-21 pubmed publisher
    Here we demonstrate that a ubiquitin E3-ligase, FBXO21, targets the multidrug resistance transporter, ABCB1, also known as P-glycoprotein (P-gp), for proteasomal degradation...