Gene Symbol: FBXO15
Description: F-box protein 15
Alias: FBX15, F-box only protein 15
Species: human
Products:     FBXO15

Top Publications

  1. He X, Zhao P, Huang Y, Cai X, Bi B, Lin J. [Genome-wide copy number microarray analysis for a boy with autism]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2019;36:157-160 pubmed publisher
    ..The patient was found to carry a terminal deletion of 18q22.3q23 (7.1 Mb), which involved FBXO15, ZNF407, ZADH2, TSHZ1, MBP and ADNP2 genes. No pathogenic CNVs were found in the parents...
  2. Jöhnk B, Bayram Ö, Abelmann A, Heinekamp T, Mattern D, Brakhage A, et al. SCF Ubiquitin Ligase F-box Protein Fbx15 Controls Nuclear Co-repressor Localization, Stress Response and Virulence of the Human Pathogen Aspergillus fumigatus. PLoS Pathog. 2016;12:e1005899 pubmed publisher
    ..F-box protein Fbx15 is part of the general stress response of the human pathogenic mold Aspergillus fumigatus...
  3. Katayama K, Fujiwara C, Noguchi K, Sugimoto Y. RSK1 protects P-glycoprotein/ABCB1 against ubiquitin-proteasomal degradation by downregulating the ubiquitin-conjugating enzyme E2 R1. Sci Rep. 2016;6:36134 pubmed publisher
    ..Proteasome inhibitors or knockdown of FBXO15 and/or UBE2R1 cancelled MEK inhibitor-induced P-gp downregulation...
  4. Donato V, Bonora M, Simoneschi D, Sartini D, Kudo Y, Saraf A, et al. The TDH-GCN5L1-Fbxo15-KBP axis limits mitochondrial biogenesis in mouse embryonic stem cells. Nat Cell Biol. 2017;19:341-351 pubmed publisher
    ..the acetyltransferase GCN5L1 cooperate to acetylate Lys501 in KBP, allowing its recognition by and degradation via Fbxo15, an F-box protein transcriptionally controlled by the pluripotency core factors and repressed following ..
  5. Katayama K, Noguchi K, Sugimoto Y. FBXO15 regulates P-glycoprotein/ABCB1 expression through the ubiquitin--proteasome pathway in cancer cells. Cancer Sci. 2013;104:694-702 pubmed publisher
    ..Among them, FBXO15/Fbx15 is known as an F-box protein in the ubiquitin E3 ligase complex, Skp1-Cullin1-FBXO15 (SCF(Fbx15) ); ..
  6. Byrne E, Gehrman P, Medland S, Nyholt D, Heath A, Madden P, et al. A genome-wide association study of sleep habits and insomnia. Am J Med Genet B Neuropsychiatr Genet. 2013;162B:439-51 pubmed publisher
    ..We did not replicate the results from previous genome-wide analyses of self-reported sleep phenotypes after correction for multiple testing. ..
  7. Simino J, Sung Y, Kume R, Schwander K, Rao D. Gene-alcohol interactions identify several novel blood pressure loci including a promising locus near SLC16A9. Front Genet. 2013;4:277 pubmed publisher
    ..near/in genes ESRRG, FAM179A, CRIPT-SOCS5, KAT2B, ADCY2, GLI3, ZNF716, SLIT1, PDE3A, KERA-LUM, RNF219-AS1, CLEC3A, FBXO15, and IGSF5...
  8. Chen B, Coon T, Glasser J, Zou C, Ellis B, Das T, et al. E3 ligase subunit Fbxo15 and PINK1 kinase regulate cardiolipin synthase 1 stability and mitochondrial function in pneumonia. Cell Rep. 2014;7:476-487 pubmed publisher
    ..Here, we show that S. aureus activates a ubiquitin E3 ligase component, Fbxo15, that is sufficient to mediate proteasomal degradation of CLS1 in epithelia, resulting in decreased cardiolipin ..
  9. Tokuzawa Y, Kaiho E, Maruyama M, Takahashi K, Mitsui K, Maeda M, et al. Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic stem cell self-renewal and mouse development. Mol Cell Biol. 2003;23:2699-708 pubmed
    ..In this study, we found that F-box-containing protein Fbx15 was expressed predominantly in mouse undifferentiated ES cells...

More Information


  1. Greliche N, Germain M, Lambert J, Cohen W, Bertrand M, Dupuis A, et al. A genome-wide search for common SNP x SNP interactions on the risk of venous thrombosis. BMC Med Genet. 2013;14:36 pubmed publisher
    ..This study, the first genome-wide SNP interaction analysis conducted so far on VT risk, suggests that common SNPs are unlikely exerting strong interactive effects on the risk of disease. ..