FBLIM1

Summary

Gene Symbol: FBLIM1
Description: filamin binding LIM protein 1
Alias: CAL, FBLP-1, FBLP1, CSX-associated LIM, MIG2-interacting protein, filamin-binding LIM protein 1, filamin-binding LIM protein-1, migfilin, mitogen-inducible 2 interacting protein, mitogen-inducible 2-interacting protein
Species: human

Top Publications

  1. ncbi Migfilin and Mig-2 link focal adhesions to filamin and the actin cytoskeleton and function in cell shape modulation
    Yizeng Tu
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Cell 113:37-47. 2003
  2. pmc Colocalization of kindlin-1, kindlin-2, and migfilin at keratinocyte focal adhesion and relevance to the pathophysiology of Kindler syndrome
    J E Lai-Cheong
    Genetic Skin Disease Group, St John s Institute of Dermatology, Division of Genetics and Molecular Medicine, King s College London, London, UK
    J Invest Dermatol 128:2156-65. 2008
  3. doi Migfilin regulates esophageal cancer cell motility through promoting GSK-3β-mediated degradation of β-catenin
    Huan He
    State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
    Mol Cancer Res 10:273-81. 2012
  4. pmc Increased cytoplasmic level of migfilin is associated with higher grades of human leiomyosarcoma
    D J Papachristou
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Histopathology 51:499-508. 2007
  5. ncbi Migfilin and its binding partners: from cell biology to human diseases
    Chuanyue Wu
    Department of Pathology, University of Pittsburgh, 707B Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    J Cell Sci 118:659-64. 2005
  6. pmc Migfilin interacts with Src and contributes to cell-matrix adhesion-mediated survival signaling
    Jianping Zhao
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 284:34308-20. 2009
  7. pmc Structural basis of the migfilin-filamin interaction and competition with integrin beta tails
    Yatish Lad
    Department of Pharmacology and Interdepartmental Program in Vascular Biology and Transplantation, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 283:35154-63. 2008
  8. ncbi A new member of the LIM protein family binds to filamin B and localizes at stress fibers
    Toshiro Takafuta
    Department of Medicine, Cardeza Foundation for Hematologic Research, Jefferson Medical College, Philadelphia, Pennsylvania 19041, USA
    J Biol Chem 278:12175-81. 2003
  9. pmc A novel LIM protein Cal promotes cardiac differentiation by association with CSX/NKX2-5
    Hiroshi Akazawa
    Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    J Cell Biol 164:395-405. 2004
  10. ncbi Migfilin interacts with vasodilator-stimulated phosphoprotein (VASP) and regulates VASP localization to cell-matrix adhesions and migration
    Yongjun Zhang
    Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 281:12397-407. 2006

Detail Information

Publications139 found, 100 shown here

  1. ncbi Migfilin and Mig-2 link focal adhesions to filamin and the actin cytoskeleton and function in cell shape modulation
    Yizeng Tu
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Cell 113:37-47. 2003
    Cell-extracellular matrix adhesion is an important determinant of cell morphology. We show here that migfilin, a LIM-containing protein, localizes to cell-matrix adhesions, associates with actin filaments, and is essential for cell shape ..
  2. pmc Colocalization of kindlin-1, kindlin-2, and migfilin at keratinocyte focal adhesion and relevance to the pathophysiology of Kindler syndrome
    J E Lai-Cheong
    Genetic Skin Disease Group, St John s Institute of Dermatology, Division of Genetics and Molecular Medicine, King s College London, London, UK
    J Invest Dermatol 128:2156-65. 2008
    ..In this study, we identified two previously unreported binding proteins of kindlin-1: kindlin-2 and migfilin. Co-immunoprecipitation and confocal microscopy studies show that these three proteins bind to each other and ..
  3. doi Migfilin regulates esophageal cancer cell motility through promoting GSK-3β-mediated degradation of β-catenin
    Huan He
    State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
    Mol Cancer Res 10:273-81. 2012
    b>Migfilin, a protein component of focal adhesions, has been implicated in regulation of cell-extracellular matrix adhesion and motility but the underlying mechanisms are not fully elucidated...
  4. pmc Increased cytoplasmic level of migfilin is associated with higher grades of human leiomyosarcoma
    D J Papachristou
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Histopathology 51:499-508. 2007
    ..Mitogen inducible gene-2 (Mig-2), kindlin and migfilin are recently identified cell-matrix adhesion proteins...
  5. ncbi Migfilin and its binding partners: from cell biology to human diseases
    Chuanyue Wu
    Department of Pathology, University of Pittsburgh, 707B Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    J Cell Sci 118:659-64. 2005
    ..One of the most recently identified is migfilin, a widely expressed protein consisting of an N-terminal filamin-binding domain, a central proline-rich domain and ..
  6. pmc Migfilin interacts with Src and contributes to cell-matrix adhesion-mediated survival signaling
    Jianping Zhao
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 284:34308-20. 2009
    ..Here we show that migfilin, an integrin-proximal adaptor protein, interacts with Src and contributes to cell-ECM-mediated survival signaling...
  7. pmc Structural basis of the migfilin-filamin interaction and competition with integrin beta tails
    Yatish Lad
    Department of Pharmacology and Interdepartmental Program in Vascular Biology and Transplantation, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 283:35154-63. 2008
    ..b>Migfilin is a recently identified adaptor protein that localizes at cell-cell and cell-extracellular matrix adhesion sites,..
  8. ncbi A new member of the LIM protein family binds to filamin B and localizes at stress fibers
    Toshiro Takafuta
    Department of Medicine, Cardeza Foundation for Hematologic Research, Jefferson Medical College, Philadelphia, Pennsylvania 19041, USA
    J Biol Chem 278:12175-81. 2003
    ..The association between filamin B and FBLP-1 may play a hitherto unknown role in cytoskeletal function, cell adhesion, and cell motility...
  9. pmc A novel LIM protein Cal promotes cardiac differentiation by association with CSX/NKX2-5
    Hiroshi Akazawa
    Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    J Cell Biol 164:395-405. 2004
    ..yeast two-hybrid screening, we identified a novel LIM domain-containing protein, named CSX-associated LIM protein (Cal), that interacts with CSX/NKX2-5...
  10. ncbi Migfilin interacts with vasodilator-stimulated phosphoprotein (VASP) and regulates VASP localization to cell-matrix adhesions and migration
    Yongjun Zhang
    Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 281:12397-407. 2006
    ..We report here that migfilin, a recently identified component of cell-matrix adhesions, is a biphasic regulator of cell migration...
  11. pmc Migfilin, a molecular switch in regulation of integrin activation
    Sujay Subbayya Ithychanda
    Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Biol Chem 284:4713-22. 2009
    ..Here we show structurally that migfilin, a novel cytoskeletal adaptor highly enriched in the integrin adhesion sites, strongly interacts with the same ..
  12. doi Photodynamic therapy as adjunct to non-surgical periodontal treatment in patients on periodontal maintenance: a randomized controlled clinical trial
    Panos Chondros
    Department of Periodontology, Radboud University Medical Center, Nijmegen, The Netherlands
    Lasers Med Sci 24:681-8. 2009
    ..BOP) at experimental sites, probing pocket depth (PPD), gingival recession (REC), and clinical attachment level (CAL). Primary outcome variables were changes in PPD and CAL...
  13. ncbi Augmented contributions of voltage-gated Ca2+ channels to contractile responses in spontaneously hypertensive rat mesenteric arteries
    K Matsuda
    Bockus Research Institute, Graduate Hospital, Philadelphia, PA 19146, USA
    Am J Hypertens 10:1231-9. 1997
    ..compared to normotensive subjects suggests that there is a greater contribution from voltage-gated Ca2+ channels (CaL) to vascular force maintenance in hypertensive arteries...
  14. pmc Does "mainstreaming" guarantee access to care for medicaid recipients with asthma?
    Y A Bair
    Graduate Group in Epidemiology and the Center for Health Services Research in Primary Care, University of California, Davis, USA
    J Gen Intern Med 16:475-81. 2001
    ..Recent reforms in the federal Medicaid program have attempted to integrate beneficiaries into the mainstream by providing them with managed care options. However, the effects of mainstreaming have not been systematically evaluated...
  15. ncbi Influence of fast, body weight and diet on serum cholesterol, triglycerides, and phospholipids concentrations in the aging rat
    J Boudet
    INSERM U 90, , Paris, France
    Horm Metab Res 20:734-7. 1988
    ..intake and daily body weight gain of old rats (40-50 weeks of age) were not significantly different with both diets tested (2900 and 3250 cal/kg). In conclusion old Wistar rats develop increased concentrations of serum lipids parameters.
  16. ncbi Prospective randomized trial to assess caloric and protein needs of critically Ill, anuric, ventilated patients requiring continuous renal replacement therapy
    C D Scheinkestel
    Department of Intensive Care, Alfred Hospital, Melbourne, Australia, Australia
    Nutrition 19:909-16. 2003
    ..We also determined whether these feeding regimes affected patient outcome...
  17. pmc Electrophysiological actions of phenytoin on N-methyl-D-aspartate receptor-mediated responses in rat hippocampus in vitro
    A J Laffling
    Department of Pharmacology, Syntex Research Centre, Edinburgh
    Br J Pharmacol 115:67-72. 1995
    ..3 x 10-6 M to 1 x 10-4M) attenuated the effects of the sodium channel activator,veratridine (2 x 10-6 M), on the CAl population spike amplitude (recorded in normal Krebs solution),indicating that the previously observed lack of ..
  18. ncbi Interaction of [D-Trp6, Des-Gly10] LHRH ethylamide and hydroxy propyl beta-cyclodextrin (HPbetaCD): thermodynamics of interaction and protection from degradation by alpha-chymotrypsin
    K N Koushik
    Department of Pharmaceutical Sciences, 986025 University of Nebraska Medical Center, Omaha, NE 68198-6025, USA
    Pharm Dev Technol 6:595-606. 2001
    ..an exothermic reaction between deslorelin and HPbetaCD with a low enthalpy of binding of approximately -600 cal/mol and a binding affinity of approximately -1.25 x 10(2) M-1...
  19. pmc Pharmacology of postsynaptic metabotropic glutamate receptors in rat hippocampal CA1 pyramidal neurones
    C H Davies
    Department of Pharmacology, Medical School, University of Birmingham
    Br J Pharmacol 116:1859-69. 1995
    ..6 From these data it is concluded that the mGluRs in CAl pyramidal neurones responsible for these excitatory effects are similar to the mGluRs expressed by non-neuronal ..
  20. ncbi Utilisation of locally delivered doxycycline in non-surgical treatment of chronic periodontitis. A comparative multi-centre trial of 2 treatment approaches
    J L Wennstrom
    Department of Periodontology, Institute of Odontology, Goteborg University, SE 405 30 Goteborg, Sweden
    J Clin Periodontol 28:753-61. 2001
    ..In the present 6-month multicentre trial, the outcome of 2 different approaches to non-surgical treatment of chronic periodontitis, both involving the use of a locally delivered controlled-release doxycycline, was evaluated...
  21. ncbi [Studies on Chlamydia pneumoniae, strain TWAR infection. 2. Seroepidemiology of TWAR on healthy controls and patients with acute respiratory infections]
    T Kishimoto
    Department of Medicine, Kawasaki Medical School
    Kansenshogaku Zasshi 64:986-93. 1990
    ..MFA) using in situ inclusions of Chlamydia pneumoniae (TW-183), Chlamydia trachomatis (L2) and Chlamydia psittaci (Cal 10) as antigens respectively...
  22. ncbi Global effects of the energetics of coenzyme binding: NADPH controls the protein interaction properties of human cytochrome P450 reductase
    Alex Grunau
    Department of Biochemistry, University of Leicester, UK
    Biochemistry 45:1421-34. 2006
    ..Similar heat capacity change (DeltaC(p)) values for 2',5'-ADP (-210 cal mol(-)(1) K(-)(1)), NADP(+) (-230 cal mol(-)(1) K(-)(1)), and H(4)NADP (-220 cal mol(-)(1) K(-)(1)) indicate no ..
  23. ncbi [Studies on Chlamydia pneumoniae, strain TWAR, infection. I. Experimental infection of C. pneumoniae in mice and serum antibodies against TWAR by MFA.]
    T Kishimoto
    Department of Medicine, Kawasaki Medical School
    Kansenshogaku Zasshi 64:124-31. 1990
    ..pneumoniae TW-183, C. psittaci Cal 10 and C. trachomatis L2 strains were assayed by MFA using in situ inclusions of each strain and compared...
  24. ncbi Supragingival plaque may modify the effects of subgingival bacteria on attachment loss
    Mine Tezal
    Department of Oral Biology, State University of New York, Buffalo, NY 14214, USA
    J Periodontol 77:808-13. 2006
    ..This study evaluates the role of supragingival plaque level on the relationship between subgingival microorganisms and the risk of attachment loss...
  25. ncbi Acute effects of prolactin on passive calcium absorption in the small intestine by in vivo perfusion technique
    N Krishnamra
    Department of Physiology, Faculty of Science, Mahidol University, Bangkok, Thailand
    Can J Physiol Pharmacol 76:161-8. 1998
    ..81 +/- 1.84 to 30.56 +/- 1.57 mmol/g dry weight (p < 0.05) by stimulating the lumen to plasma calcium flux (CaL-P). The jejunum responded to 0.2, 0.4, and 0...
  26. ncbi Evaluation of the first year of a pilot program in community pharmacy: HIV/AIDS medication therapy management for Medi-Cal beneficiaries
    Jan D Hirsch
    University of California, San Diego, Skaggs School of Pharmacy and Pharmaceutical Sciences, 9500 Gilman Drive, Mail Code 0714, La Jolla, CA 92093 0714, USA
    J Manag Care Pharm 15:32-41. 2009
    ..In January 2005, a pilot program to evaluate MTM services for patients with HIV/AIDS began in California, allowing 10 HIV/AIDS specialty pharmacies to receive compensation for the MTM services that they provided to HIV/AIDS patients...
  27. ncbi Local anti-infective therapy: pharmacological agents. A systematic review
    Philip J Hanes
    Department of Periodontics, Medical College of Georgia, School of Dentistry, Augusta, GA 30912 1220, USA
    Ann Periodontol 8:79-98. 2003
    ..Over the past 20 years, locally delivered, anti-infective pharmacological agents, most recently employing sustained-release vehicles, have been introduced to achieve this goal...
  28. doi Clinical, microbiologic, and biochemical effects of subgingival administration of a Xanthan-based chlorhexidine gel in the treatment of periodontitis: a randomized multicenter trial
    Michele Paolantonio
    Department of Periodontology, School of Dentistry, University G D Annunzio, Chieti, Italy
    J Periodontol 80:1479-92. 2009
    ..The present multicenter randomized study investigated the effects of a xanthan-based chlorhexidine (Xan-CHX) gel used as an adjunct to scaling and root planing (SRP) in the treatment of chronic periodontitis...
  29. ncbi Bioabsorbable membrane and bioactive glass in the treatment of intrabony defects in patients with generalized aggressive periodontitis: results of a 5-year clinical and radiological study
    Reiner Mengel
    Department of Periodontology, Philipps University Marburg, Marburg, Germany
    J Periodontol 77:1781-7. 2006
    ....
  30. ncbi Cost and utilization impacts of oral antihistamines in the California Medi-Cal program
    Joel W Hay
    Department of Pharmaceutical Economics and Policy, University of Southern California, Los Angeles, CA 90089, USA
    Value Health 8:506-16. 2005
    ..There are no empirical studies comparing the costs of treatment of SGAs relative to FGAs...
  31. ncbi Noninvasive markers in the assessment of intestinal inflammation in inflammatory bowel diseases: performance of fecal lactoferrin, calprotectin, and PMN-elastase, CRP, and clinical indices
    Jost Langhorst
    Department of Internal and Integrative Medicine, Kliniken Essen Mitte, University of Duisburg Essen, Germany
    Am J Gastroenterol 103:162-9. 2008
    The aim of this study was to compare the performance of fecal lactoferrin (Lf), calprotectin (Cal), polymorphonuclear neutrophil elastase (PMN-e), as well as serum C-reactive protein (CRP) in patients with inflammatory bowel diseases (..
  32. ncbi In most poorly controlled glyburide-treated type 2 diabetic patients drug withdrawal causes further increase in glycemia not accompanied by changes in insulin secretion
    A Lev-Ran
    Zamenhof Clinic, General Sick Fund, Tel-Aviv, Israel
    Horm Metab Res 30:108-10. 1998
    ..6%). Serum glucose, insulin and C-peptide were assayed before and 1 h and 2 h after a simulated meal load (355 Cal), after which the drug was replaced with placebo for 4 weeks, and the test repeated...
  33. ncbi Interleukin-1 gene polymorphisms and long-term stability following guided tissue regeneration therapy
    M De Sanctis
    Department of Periodontology, Bologna University, Italy
    J Periodontol 71:606-13. 2000
    ..The aim of the present study was to evaluate the impact of genotype on the maintenance of gained clinical attachment obtained after guided tissue regeneration (GTR) surgical therapy in deep intrabony defects...
  34. ncbi Theophylline for irreversible chronic airflow limitation: a randomized study comparing n of 1 trials to standard practice
    J L Mahon
    Department of Medicine, University of Western Ontario, Canada
    Chest 115:38-48. 1999
    ..aim), and drug usage (secondary aim), between groups of patients with irreversible chronic airflow limitation (CAL) who were undergoing theophylline Theo-Dur; Key Pharmaceuticals; Kenilworth, NJ) therapy guided by n of 1 trials or ..
  35. ncbi Treatment of intrabony defects with enamel matrix proteins and guided tissue regeneration. A prospective controlled clinical study
    A Sculean
    Department of Periodontology and Conservative Dentistry, University of Saarland, Homburg, Germany
    J Clin Periodontol 28:397-403. 2001
    ..However, it is yet unknown whether the combination of EMD and GTR may additionally favor the regeneration process...
  36. ncbi Surgical treatment of periodontal intrabony defects with calcium sulfate implant and barrier versus collagen barrier or open flap debridement alone: a 12-month randomized controlled clinical trial
    Michele Paolantonio
    Department of Periodontology, University G D Annunzio School of Dentistry, Chieti, Italy
    J Periodontol 79:1886-93. 2008
    ....
  37. doi The calcium/calmodulin/kinase system and arrhythmogenic afterdepolarizations in bradycardia-related acquired long-QT syndrome
    Xiaoyan Qi
    Department of Medicine and Research Center, Montreal Heart Institute and Universite de Montreal, Montreal, Quebec, Canada
    Circ Arrhythm Electrophysiol 2:295-304. 2009
    ..We addressed the importance of altered Ca(2+) handling, studying underlying mechanisms and consequences...
  38. ncbi Effect of platelet-rich plasma on the healing of intrabony defects treated with Beta tricalcium phosphate and expanded polytetrafluoroethylene membranes
    Ferenc Dori
    Department of Periodontology, Semmelweis University, Budapest, Hungary
    J Periodontol 79:660-9. 2008
    ....
  39. ncbi Factors associated with periodontal diseases in a dental teaching clinic population in northern Jordan
    Yousef S Khader
    Department of Community Medicine, Public Health and Family Medicine, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan
    J Periodontol 74:1610-7. 2003
    ..a dental teaching center serving a local population in northern Jordan was performed to identify the factors associated with probing depth (PD), clinical attachment level (CAL), gingival recession (GR), and number of missing teeth (MT).
  40. ncbi The Alternaria alternata melanin biosynthesis gene restores appressorial melanization and penetration of cellulose membranes in the melanin-deficient albino mutant of Colletotrichum lagenarium
    Y Takano
    Laboratory of Plant Pathology, Faculty of Agriculture, Kyoto University, Japan
    Fungal Genet Biol 21:131-40. 1997
    ..The ALM gene transformed the albino mutant (Pks1-) to melanin-producing phenotypes, designated CAL transformants...
  41. ncbi Cathepsins B and L increased during response of periodontal ligament cells to mechanical stress in vitro
    Masaru Yamaguchi
    Department of Orthodontics, Nihon University School of Dentistry at Matsudo, Sakaecho Nishi, Chiba, Japan
    Connect Tissue Res 45:181-9. 2004
    ..A recent immunocytochemical study demonstrated that cathepsins B (CAB) and L (CAL) were localized in the periodontal ligament (PDL) of the rat molar, and they were expressed in compressed sites ..
  42. ncbi Comparison of clinical outcomes following treatment of chronic adult periodontitis with subgingival scaling or subgingival scaling plus metronidazole gel
    G S Griffiths
    Department of Periodontology, Eastman Dental Institute and Hospital for Oral Health Care Sciences, University College London, UK
    J Clin Periodontol 27:910-7. 2000
    ..This 2-centre study compared the clinical effects of subgingival scaling (SRP) with SRP plus subgingival application of 25% metronidazole gel, Elyzol (SRP+gel), in patients with chronic adult periodontitis...
  43. ncbi Heightened gingival inflammation and attachment loss in type 2 diabetics with hyperlipidemia
    C W Cutler
    Department of Periodontics, Baylor College of Dentistry TAMUHSC, Dallas, TX 75266 0677, USA
    J Periodontol 70:1313-21. 1999
    ..The objective of the present study was to determine if diabetes has a similar dysregulatory effect on the gingival response to AP in humans...
  44. ncbi Five-year results following treatment of intrabony defects with enamel matrix proteins and guided tissue regeneration
    Anton Sculean
    Department of Conservative Dentistry and Periodontology, Section of Periodontology, Johannes Gutenberg University, Mainz, Germany
    J Clin Periodontol 31:545-9. 2004
    ..Aim: The aim of the present clinical study was to present the 5-year results following treatment of intrabony defects with EMD, GTR, combination of EMD and GTR, and open flap debridement (OFD)...
  45. pmc Evidence for dimer participation and evidence against channel mechanism in A23187-mediated monovalent metal ion transport across phospholipid vesicular membrane
    B S Prabhananda
    Department of Chemical Sciences, Tata Institute of Fundamental Research, Mumbai 400 005, India
    Biophys J 75:1749-58. 1998
    The decay of the pH difference (DeltapH) across soybean phospholipid vesicular membrane by ionophore A23187 (CAL)-mediated H+/M+ exchange (M+ = Li+, Na+, K+, and Cs+) has been studied in the pH range 6-7.6...
  46. doi Biomechanical evaluation of an augmented coracoacromial ligament transfer for acromioclavicular joint instability
    Mathias Wellmann
    Department of Orthopaedic Surgery, Hannover Medical School, Hannover, Germany
    Arthroscopy 24:1395-401. 2008
    The purpose of this study was to establish and biomechanically evaluate an augmented coracoacromial ligament (CAL) transfer technique that eliminates the biomechanical drawbacks of the conventional Weaver-Dunn procedure and restores the ..
  47. ncbi Cytokine profile in gingival crevicular fluid of aggressive periodontitis: influence of smoking and stress
    Joanna J Kamma
    J Clin Periodontol 31:894-902. 2004
    ..Cytokine production may also be influenced by smoking and stress leading to an imbalance that disturbs the host-parasite relationship...
  48. ncbi Developmental absence of the O2 sensitivity of L-type calcium channels in preterm ductus arteriosus smooth muscle cells impairs O2 constriction contributing to patent ductus arteriosus
    Bernard Thebaud
    Department of Pediatrics, Division of Neonatology, University of Alberta, Edmonton, T6G 2J3, AB, Canada
    Pediatr Res 63:176-81. 2008
    ..This paradigm suggests that activation of the voltage-sensitive L-type calcium channels (CaL), which increases cytosolic calcium ([Ca2+]i), is a passive consequence of membrane depolarization...
  49. ncbi Comparative evaluation of subgingivally delivered 10% doxycycline hyclate and xanthan-based chlorhexidine gels in the treatment of chronic periodontitis
    Rajan Gupta
    Department of Periodontics, D A V C Dental College in Yamunanagar, Haryana, India
    J Contemp Dent Pract 9:25-32. 2008
    ....
  50. pmc Diminished treatment response of periodontally diseased patients infected with the JP2 clone of Aggregatibacter (Actinobacillus) actinomycetemcomitans
    Sheila Cavalca Cortelli
    Department of Periodontology, Dental Research Division, University of Taubate, Taubate, Sao Paulo, Brazil
    J Clin Microbiol 47:2018-25. 2009
    ..Probing depth (PD), clinical attachment level (CAL), and gingival and plaque indices (GI and PI, respectively) were monitored at baseline and at 12 months, along with ..
  51. ncbi Vitamin D receptor alleles, periodontal disease progression, and tooth loss in the VA dental longitudinal study
    Koji Inagaki
    Department of Health Policy and Health Services Research, Boston University Goldman School of Dental Medicine, Boston, MA, USA
    J Periodontol 74:161-7. 2003
    ..The relationship between the vitamin D receptor (VDR) genotype and periodontal disease is not known. This study compared periodontal disease progression among polymorphisms of 2 VDR genes in men in the VA Dental Longitudinal Study...
  52. ncbi The effect of subgingival controlled-release delivery of chlorhexidine chip on clinical parameters and matrix metalloproteinase-8 levels in gingival crevicular fluid
    Nezih Azmak
    Department of Periodontology, Faculty of Dentistry, Ege University, Izmir, Turkey
    J Periodontol 73:608-15. 2002
    ....
  53. ncbi Periodontal treatment with an Er: YAG laser compared to scaling and root planing. A controlled clinical study
    F Schwarz
    Department of Periodontology and Conservative Dentistry, University of the Saarland, Homburg, Germany
    J Periodontol 72:361-7. 2001
    ..The aim of the present study was to compare the effectiveness of an Er:YAG laser to that of scaling and root planing for non-surgical periodontal treatment...
  54. ncbi Local versus systemic adjunctive antibiotic therapy in 28 patients with generalized aggressive periodontitis
    P Purucker
    Department of Periodontology and Synoptic Dentistry, University Hospital Charite, Humboldt University at Berlin, Germany
    J Periodontol 72:1241-5. 2001
    ..The purpose of the present study was to compare the clinical response of local versus systemic antibiotic treatment as adjuncts to scaling and root planing in patients with GAgP...
  55. ncbi Effect of platelet-rich plasma on the healing of intrabony defects treated with an anorganic bovine bone mineral and expanded polytetrafluoroethylene membranes
    Ferenc Dori
    Department of Periodontology, Semmelweis University, Budapest, Hungary
    J Periodontol 78:983-90. 2007
    ..This study aimed to clinically evaluate the effect of PRP on the healing of deep intrabony defects treated with ABBM and GTR by means of a non-resorbable expanded polytetrafluoroethylene (ePTFE) membrane...
  56. ncbi [Reactivity of Chlamydia pneumoniae strains in the IDEIA CHLAMYDIA test kit designed for detection of Chlamydia trachomatis]
    N Miyashita
    Department of Microbiology, Kawasaki Medical School
    Kansenshogaku Zasshi 67:549-55. 1993
    ..8 x 10(4); and YK-41, 4.0 x 10(4) per assay. The number of EBs of C. trachomatis L2/434/Bu and C. psittaci Cal 10 were 1.0 x 10(3) and 2.7 x 10(4) per assay, respectively. The results demonstrated that the EBs of C...
  57. pmc Differential interactions of Na+ channel toxins with T-type Ca2+ channels
    Hui Sun
    Excigen, Inc, Baltimore, MD 21224, USA
    J Gen Physiol 132:101-13. 2008
    Two types of voltage-dependent Ca(2+) channels have been identified in heart: high (I(CaL)) and low (I(CaT)) voltage-activated Ca(2+) channels...
  58. ncbi Canadian physical therapists' interest in web-based and computer-assisted continuing education
    Sunita Mathur
    School of Rehabilitation Sciences, University of British Columbia, T325 2211 Wesbrook Mall, Vancouver, British Columbia, Canada V6T 2B5
    Phys Ther 85:226-37. 2005
    Distance education via computer-assisted learning (CAL), including Web-based and CD-ROM learning, confers a number of advantages compared with traditional learning methods...
  59. ncbi Isolation of cell wall mutants in Aspergillus nidulans by screening for hypersensitivity to Calcofluor White
    Terry W Hill
    Department of Biology, Rhodes College, Memphis, TN 38112, USA
    Mycologia 98:399-409. 2006
    ..All cal mutants are impaired for sporulation at 30 C or 42 C or both, and in eight of the 10 mutations this sporulation ..
  60. ncbi Prediction of drug-drug interactions for AUCoral of high clearance drug from in vitro data: utilization of a microtiter plate assay and a dispersion model
    Takahito Yamamoto
    Drug Metabolism Laboratory, Medicinal Development Research Laboratories, Taisho Pharmaceutical Co, Ltd, 403, Yoshino Cho 1 Chome, Kita ku, Saitama shi, Saitama 331 9530, Japan
    Curr Drug Metab 7:135-46. 2006
    ..When the K(i) values (K(i-cal)) obtained from the microtiter plate (MTP) assay and the reported K(i) values (K(i-rep)) for these drugs were used ..
  61. ncbi Intermolecular C-H bond activation reactions promoted by transient titanium alkylidynes. Synthesis, reactivity, kinetic, and theoretical studies of the Ti[triple bond]C linkage
    Brad C Bailey
    Molecular Structure Center and School of Informatics, Department of Chemistry, Indiana University, Bloomington, Indiana 47405, USA
    J Am Chem Soc 129:8781-93. 2007
    ..9(5) at 40 degrees C) with activation parameters DeltaH = 24(7) kcal/mol and DeltaS = -2(3) cal/mol.K, and the post-rate-determining step to be C-H bond activation of benzene (primary KIE = 1...
  62. ncbi Impaired healing response of periodontal furcation defects following flap debridement surgery in smokers. A controlled clinical trial
    Leonardo Trombelli
    Research Center for Study of Periodontal Diseases, University of Ferrara, Ferrara, Italy
    J Clin Periodontol 30:81-7. 2003
    ..The purpose of the present parallel-design, controlled clinical trial was to evaluate the treatment outcome of periodontal furcation defects following flap debridement surgery (FDS) procedure in cigarette smokers compared to non-smokers...
  63. pmc Proteomic but not enzyme-linked immunosorbent assay technology detects amniotic fluid monomeric calgranulins from their complexed calprotectin form
    Irina A Buhimschi
    Department of Obstetrics, Gynecology, and Reproductive Science, Yale University School of Medicine, 333 Cedar Street LCI 804, P O Box 208063, New Haven, CT 06520 8063, USA
    Clin Diagn Lab Immunol 12:837-44. 2005
    Four proteomic biomarkers (human neutrophil peptide 1 [HNP1], HNP2 [defensins], calgranulin C [Cal-C], and Cal-A) characterize the fingerprint of intra-amniotic inflammation (IAI)...
  64. doi Viscero-visceral hyperalgesia: characterization in different clinical models
    Maria Adele Giamberardino
    Department of Medicine and Science of Aging, G D Annunzio University of Chieti, Italy
    Pain 151:307-22. 2010
    ..b) irritable bowel syndrome (IBS)+dysmenorrhea (Dys) (T10-L1); (c) dysmenorrhea/endometriosis+urinary calculosis (Cal)(T10-L1); and (d) gallstone+left urinary calculosis (Gs+LCal) (unknown common projection) were compared with ..
  65. ncbi Secondary prevention of low-back pain. A clinical trial
    M Donchin
    Department of Social Medicine, Hebrew University Hadassah School of Public Health and Community Medicine, Jerusalem, Israel
    Spine (Phila Pa 1976) 15:1317-20. 1990
    ..Participants were randomly assigned to one of three groups: a calisthenics program (CAL) for 3 months with biweekly sessions of flexion exercises, a back school program (5 sessions), and a control group...
  66. pmc Insulin-like growth factor 1 (IGF-1) enhances the protein expression of CFTR
    Ha Won Lee
    Department of Physiology, Johns Hopkins University, School of Medicine, Baltimore, MD, USA
    PLoS ONE 8:e59992. 2013
    ..in human cells that IGF-1 increases the steady-state levels of mature wildtype CFTR in a CFTR-associated ligand (CAL)- and TC10-dependent manner; moreover, IGF-1 increases CFTR-mediated chloride transport...
  67. doi TMEM158 and FBLP1 as novel marker genes of cisplatin sensitivity in non-small cell lung cancer cells
    Ahmed El Sayed Mohammed
    Translational Research Center, Saitama Medical University International Medical Center, Hidaka, Saitama, Japan
    Exp Lung Res 38:463-74. 2012
    ..microarray and real-time RT-PCR provided 6 candidate genes, namely, NUBPL, C9orf30, ZNF12, TMEM158, GSK3B, and FBLP1 using 9 lung cancer cells consisting of 3 small and 6 NSCLC cells...
  68. ncbi The effectiveness of computer-aided, self-instructional programs in dental education: a systematic review of the literature
    Harold Rosenberg
    Department of Pharmacology, Faculty of Dentistry, University of Toronto, Ontario, Canada MSG1G8
    J Dent Educ 67:524-32. 2003
    Computer-aided learning (CAL), self-instructional programs provide an accessible, interactive, and flexible way of presenting curriculum material...
  69. pmc Migfilin's elimination from osteoarthritic chondrocytes further promotes the osteoarthritic phenotype via β-catenin upregulation
    Vasiliki Gkretsi
    Center for Research and Technology Thessaly CE RE TE TH, Department of Biomedical Research and Technology, Larissa 41222, Greece
    Biochem Biophys Res Commun 430:494-9. 2013
    ..of novel cell-ECM adhesion-related molecules such as Iintegrin Linked Kinase (ILK), PINCH, parvin, Mig-2 and Migfilin in OA pathogenesis using primary human articular chondrocytes from healthy individuals and OA patients...
  70. ncbi Glutaraldehyde cross-linking of lipases adsorbed on aminated supports in the presence of detergents leads to improved performance
    Gloria Fernandez-Lorente
    Departamento de Biocatalisis, Instituto de Catalisis CSIC, Campus UAM, Cantoblanco, Madrid, Spain
    Biomacromolecules 7:2610-5. 2006
    Lipases from Candida rugosa (CRL) and lipase isoforms A and B from Candida antarctica (CAL-A and CAL-B) were adsorbed on aminated supports in the presence of detergents to have individual lipase molecules...
  71. pmc Migfilin protein promotes migration and invasion in human glioma through epidermal growth factor receptor-mediated phospholipase C-γ and STAT3 protein signaling pathways
    Yunwei Ou
    Department of Neurosurgery, Beijing Sanbo Brain Hospital, Capital Medical University, Beijing 100093, China
    J Biol Chem 287:32394-405. 2012
    b>Migfilin is critical for cell shape and motile regulation. However, its pathological role in glioma is unknown...
  72. ncbi Growth inhibition in rats fed inadequate and incomplete proteins: repercussion on mandibular biomechanics
    Clarisa Bozzini
    Department of Physiology, University of Buenos Aires School of Dentistry, Buenos Aires, Argentina
    Acta Odontol Latinoam 26:43-53. 2013
    ..Female rats aged 30 d were fed freely with one of two diets, control (CD, 301 Cal/100g) and experimental (ED, 359 Cal/100g)...
  73. ncbi The effects of a calisthenics and a light strength training program on lower limb muscle strength and body composition in mature women
    Thomai Tsourlou
    Human Performance and Coaching Laboratory, Department of Physical Education and Sport Sciences of Thessaloniki, Aristotelian University, 54006 Thessaloniki, Greece
    J Strength Cond Res 17:590-8. 2003
    This study evaluated and compared the effectiveness of an aerobics-calisthenics (A-CAL) and an aerobics/weight training (A-WT) programs on lower limb strength and body fat (%). Thirty-five adult women (age 42.1 +/- 5...
  74. doi Correlation of interdental and interradicular bone loss in patients with chronic periodontitis: a clinical and radiographic study
    S R Desai
    Department of Periodontics, H K E Society s S Nijalingappa Institute of Dental Sciences and Research, Gulbarga, Karnataka, India
    Niger J Clin Pract 15:125-31. 2012
    ..The aim of this study was to investigate the correlation between interdental and interradicular bone loss and clinical parameters in patients with chronic periodontitis...
  75. pmc Computational design of a PDZ domain peptide inhibitor that rescues CFTR activity
    Kyle E Roberts
    Department of Computer Science, Duke University, Durham, North Carolina, United States of America
    PLoS Comput Biol 8:e1002477. 2012
    ..but ΔF508-CFTR can still be rapidly degraded via a lysosomal pathway involving the CFTR-associated ligand (CAL), which binds CFTR via a PDZ interaction domain...
  76. ncbi [Biomechanical study on proximally based conjoined tendon transfer for coracoacromial ligament reconstruction as anterosuperior restraint of shoulder]
    Xiaochuan Hu
    Department of Orthopaedics, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P R China
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 23:1469-73. 2009
    ..arch disruption in cadaveric specimens, use proximally based conjoined tendon transfer for coracoacromial ligament (CAL) reconstruction to restrain against superior humeral subluxation, and investigate its feasibility and biomechanics ..
  77. pmc Defective calcium inactivation causes long QT in obese insulin-resistant rat
    Yen Chang Lin
    Center for Cardiovascular and Respiratory Sciences, Department of Physiology and Pharmacology, Robert C Byrd Health Sciences Center, West Virginia University, Morgantown, WV 26056, USA
    Am J Physiol Heart Circ Physiol 302:H1013-22. 2012
    ..Furthermore, the L-type calcium current (I(CaL)) in OZR exhibited defective inactivation and lost the complete inactivation back to the closed state, leading to ..
  78. ncbi German dental faculty attitudes towards computer-assisted learning and their correlation with personal and professional profiles
    A Welk
    Department of Restorative Dentistry, Periodontology, and Paediatric Dentistry, University of Greifswald, Greifswald, Germany
    Eur J Dent Educ 9:123-30. 2005
    ..Compared with its potential, computer technology use is still lacking in medical/dental education...
  79. ncbi Body weight and body composition changes after treatment of hyperthyroidism
    L Lonn
    Department of Radiology, Sahlgrenska University Hospital, University of Goteborg, Sweden
    J Clin Endocrinol Metab 83:4269-73. 1998
    ..7 kg (P < 0.001) after 3 and 12 months of euthyroidism, respectively. Basal metabolic rate decreased from 2087 Cal/24 h at diagnosis to 1601 Cal/24 h at 12 months (P=0...
  80. doi Levofloxacin-based and clarithromycin-based triple therapies as first-line and second-line treatments for Helicobacter pylori infection: a randomised comparative trial with crossover design
    Jyh Ming Liou
    Department of Internal Medicine and Primary Care Medicine, National Taiwan University Hospital, National Taiwan University, College of Medicine, No 7 Chung Shan S Road, Taipei, Taiwan
    Gut 59:572-8. 2010
    ..The aim of this study was to assess the eradication rates of these two regimens using different administration sequences...
  81. pmc Missed opportunities for osteoporosis treatment in patients hospitalized for hip fracture
    Lee A Jennings
    San Francisco VA Medical Center, and Department of Medicine, University of California San Francisco, San Francisco, California, USA
    J Am Geriatr Soc 58:650-7. 2010
    ..The objective of this study was to examine rates of in-hospital treatment with a combination of calcium and vitamin D (Cal+D) and antiresorptive or bone-forming medications in patients hospitalized for hip fractures
  82. doi The roles of three Serratia marcescens chitinases in chitin conversion are reflected in different thermodynamic signatures of allosamidin binding
    Jamil Baban
    Department of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, P O Box 5003, N 1432 As, Norway
    J Phys Chem B 114:6144-9. 2010
    ..3 kcal/mol for ChiC). For ChiC, the entropic term is dominated by changes in solvation entropy (DeltaS(conf) = 1 cal/K.mol and DeltaS(solv) = 31 cal/K...
  83. doi Topical hydrocortisone, clobetasol propionate, and calcipotriol do not increase photocarcinogenesis induced by simulated solar irradiation in hairless mice
    Catharina M Lerche
    Department of Dermatology, Copenhagen University Hospital, Bispebjerg, Copenhagen, Denmark
    Exp Dermatol 19:973-9. 2010
    ..HCB) and clobetasol-17-propionate (CP) and vitamin D(3) derivatives such as calcipotriol (CAL) are widely used to treat psoriasis...
  84. ncbi Treatment of intrabony defects using guided tissue regeneration or enamel matrix derivative: a 3-year prospective randomized clinical study
    Alessandro Crea
    Division of Periodontology, Catholic University of Sacred Heart, Rome, Italy
    J Periodontol 79:2281-9. 2008
    ..The aim of this randomized, controlled, prospective clinical study was to compare guided tissue regeneration (GTR) to enamel matrix derivative (EMD) for the treatment of intrabony defects in patients with chronic advanced periodontitis...
  85. ncbi Models to evaluate the role of stress in periodontal disease
    R J Genco
    Department of Oral Biology, School of Dental Medicine, State University of New York at Buffalo, USA
    Ann Periodontol 3:288-302. 1998
    ..of supragingival plaque, subgingival flora, gingival bleeding, calculus, probing depth, clinical attachment level (CAL), and radiographic alveolar bone loss (ABL) were obtained for each subject...
  86. doi The effect of prescription omega-3 fatty acids on body weight after 8 to 16 weeks of treatment for very high triglyceride levels
    Harold E Bays
    Louisville Metabolic and Atherosclerosis Research Center, Louisville, KY 40213, USA
    Postgrad Med 121:145-50. 2009
    ..The caloric content associated with each 1-g capsule of P-OM3 is approximately 11 Cal (Cal = kilocalories) - approximately 9 Cal from the oil in the capsule that contains omega-3 fat and approximately ..
  87. ncbi Access to orthopedic care for children with medicaid versus private insurance in California
    D L Skaggs
    Childrens Hospital Los Angeles, University of Southern California, Keck School of Medicine, Los Angeles, California, USA
    Pediatrics 107:1405-8. 2001
    To compare the availability of timely orthopedic care to a child with a fractured arm insured by Medi-Cal (California state Medicaid) and by private insurance.
  88. ncbi Regulation of collagenolytic protease secretion through c-Src in osteoclasts
    N Furuyama
    Discovery Research Laboratory, Takeda Chemical Industries, Ltd, Osaka, Japan
    Biochem Biophys Res Commun 272:116-24. 2000
    ..in the synthesis and secretion of the collagenolytic cysteine proteases (CCPs), cathepsin K (CAK), cathepsin L (CAL), and cathepsin B (CAB), by osteoclasts was investigated...
  89. ncbi Dental student assessment of learning programmes
    D J Lamb
    Department of Restorative Dentistry, School of Clinical Dentistry, University of Sheffield, UK
    Eur J Dent Educ 3:10-4. 1999
    To compare relevance, accessibility, role in the teaching-learning process, and user preference, of identical case-study-based teaching programmes in CAL and booklet format.
  90. ncbi Pharmaceutical properties of related calanolide compounds with activity against human immunodeficiency virus
    R A Newman
    Clinical Pharmacology Resource Facility, University of Texas, M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Pharm Sci 87:1077-80. 1998
    ..Both (+)-calanolide A (Cal A; NSC 675451) and (+)-dihydrocalanolide A (DHCal A; NSC 678323) are currently under development for the treatment ..
  91. ncbi Mitochondrial DNA and Y chromosome diversity and the peopling of the Americas: evolutionary and demographic evidence
    Theodore G Schurr
    Department of Anthropology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Am J Hum Biol 16:420-39. 2004
    ..The initial migration seems to have occurred between 20,000-15,000 calendar years before present (cal BP), i.e., before the emergence of Clovis lithic sites (13,350-12,895 cal BP) in North America...
  92. doi 120 infrabony defects treated with regenerative therapy: long-term results
    Maurizio Silvestri
    Unit of Periodontology, Department of Surgical, Reconstructive, and Diagnostic Sciences, University of Milan, Foundation IRCCS Cà Granda, Milan, Italy
    J Periodontol 82:668-75. 2011
    ..The aim of this study is to evaluate the long-term benefits of regenerative therapy and which factors (i.e., smoking, oral hygiene, radiographic angle, tooth, clinical center, and biomaterial) influence results...
  93. ncbi A systematic review of computer-assisted learning in endodontics education
    Thikriat S Al-Jewair
    Department of Orthodontics, School of Dental Medicine, University at Buffalo, 140 Squire Hall, Buffalo, NY 14214, USA
    J Dent Educ 74:601-11. 2010
    Results of the efficacy and time efficiency of computer-assisted learning (CAL) in endodontics education are mixed in the literature...
  94. ncbi Identification and developmental expression of a chicken calsequestrin homolog
    E S Choi
    Department of Biological Sciences, University of California, Santa Barbara 93106
    Dev Biol 142:169-77. 1990
    Calsequestrin (CAL) is a calcium-binding protein whose primary function is thought to involve sequestration of calcium in the muscle sarcoplasmic reticulum (SR)...
  95. ncbi Clinical assessment of periodontitis in young adults--evaluation of probing depth and partial recording methods
    D M Agerholm
    King's College School of Medicine and Dentistry, London, United Kingdom
    Community Dent Oral Epidemiol 24:56-61. 1996
    ..Comparisons were made between full mouth approximal attachment loss (CAL) assessment and methods relying on pocket probing depth (PPD) evaluation or on partial recording of CAL or PPD...
  96. ncbi Differences in corticotropin-releasing hormone-stimulated adrenocorticotropin and cortisol before and after weight loss
    J A Yanovski
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 82:1874-8. 1997
    ..0 +/- 7.9-kg weight loss induced by a 26-week weight loss program that included 12 weeks of a 3350 kJ/day (800 Cal/day) liquid formula diet, 6 weeks of gradual refeeding, and 6 weeks of caloric stabilization at 5020-6280 kJ/day (..
  97. ncbi The relationship between radiographic and clinical changes in the periodontium
    E E Machtei
    Department of Oral Biology, School of Dental Medicine, State University of New York at Buffalo 14214 3092, USA
    J Periodontal Res 32:661-6. 1997
    Change in clinical attachment level (CAL) and radiographic change in crestal bone height are often used to assess periodontal breakdown and disease progression. These two variables are also used to monitor the effect of treatment...
  98. ncbi Effects of expanded polytetrafluoroethylene and polylactic acid barriers on healthy sites
    P M Trejo
    The University of Texas, Health Science Center, Department of Stomatology, Houston 77030 3402, USA
    J Periodontol 69:14-8. 1998
    ..ePTFE) and polylactic acid (PLA) barrier devices on probing depth (PD), clinical attachment level (CAL), and crestal bone height in healthy sites...
  99. ncbi Calyculin A modulates the kinetic constants for the Na+-coupled taurine transport in Ehrlich ascites tumour cells
    J Mollerup
    The August Krogh Institute, Biochemical Department, University of Copenhagen, 13 Universitetsparken, DK 2100 Copenhagen, Denmark
    Biochim Biophys Acta 1371:335-44. 1998
    The effect of the phosphatase inhibitor calyculin A (cal A) on the kinetic parameters of the Na+-coupled taurine uptake via the taurine transporter in the Ehrlich ascites tumour cells has been investigated...
  100. doi CAL-101: a phosphatidylinositol-3-kinase p110-delta inhibitor for the treatment of lymphoid malignancies
    Jorge J Castillo
    The Miriam Hospital, Division of Hematology and Oncology, 164 Summit Ave, Providence, RI 02906, USA
    Expert Opin Investig Drugs 21:15-22. 2012
    ..The PI3K pathway seems to play a seminal role in the development of lymphoid malignancies. CAL-101 is a highly selective PI3K p110δ inhibitor currently undergoing clinical development.
  101. doi Decrease of tight junction integrity in the ipsilateral thalamus during the acute stage after focal infarction and ablation of the cerebral cortex in rats
    Jing Jing Li
    Department of Neurology and Stroke Center, First Affiliated Hospital, Sun Yat Sen University, Guangzhou, China
    Clin Exp Pharmacol Physiol 38:776-82. 2011
    ..thalamus during the acute stage after middle cerebral artery occlusion (MCAO) and cortical aspiration lesion (CAL) in rats. 2...

Research Grants62

  1. Impact of Antibiotics and Vaccines on the in vivo Evolution of S. pneumoniae
    Garth Ehrlich; Fiscal Year: 2009
    ..1II1 IIF ]II[ iIiI 8.1I I IUI II iIiI 9. TotatallFundsrrequesttedforralllSeniiorrKeyPersonsininttheatachedfiille Cal. Acad. Sum. .*. Requested *.. Fringe ....
  2. Mechanical Stress and the Heat-Treatment of Soft Tissue
    JAY HUMPHREY; Fiscal Year: 2003
    ..of multiaxial stresses on the thermal process as well as the effects of thermal damage on the multiaxial mechani-cal properties. No such data are available...
  3. Chicago Endothelial Function Study
    Louise C Hawkley; Fiscal Year: 2010
    ..INITIAL BUDGET PERIOD DIRECT COSTS ONLY PERSONNEL (Applicant organization only) Months Devoted to Project ROLE ON Cal. Acad. Summer INST...
  4. Chicago Endothelial Function Study
    LOUISE HAWKLEY; Fiscal Year: 2009
    ..INITIAL BUDGET PERIOD DIRECT COSTS ONLY PERSONNEL (Applicant organization only) Months Devoted to Project ROLE ON Cal. Acad. Summer INST...
  5. DIETARY COMPOSITION, OBESITY, AND CARDIOVASCULAR RISK
    ERNST SCHAEFER; Fiscal Year: 2003
    ..mono) fat; 6 percent polyunsaturated (poly) fat, with 150 mg of cholesterol/1000 calories and 10 g/1000 cal. of fiber)...
  6. Regulation of Vascular Tone and Ca channels by Integrins
    Michael Davis; Fiscal Year: 2009
    ..vascular tone: 1) mechanotransduction of intravascular pressure through the voltage-gated, L-type Ca2+ channel (CaL), which is the primary Ca2+ entry pathway in VSM, and 2) the effects of biologically active matricryptins (i.e...
  7. Computational Active-Site Redesign and Binding Prediction via Molecular Ensembles
    Bruce R Donald; Fiscal Year: 2010
    ..algorithms to redesign two restriction endonucleases (REs), and will apply K to design peptide inhibitors for the CAL (Cystic fibrosis transmembrane conductance regulator Associated Ligand) PDZ domain...
  8. Physiology of LGR7 and LGR8 in Gonadal Tissues
    Aaron Hsueh; Fiscal Year: 2007
    ..relaxin is produced by ovarian luteal cells whereas INSL3 is produced by testis Leydig cells as well as ovarian the cal and luteal cells, their physiological roles in the gonads are unclear...
  9. Enediyne Biosynthesis and Engineering
    Ben Shen; Fiscal Year: 2009
    ..involved in enediyne biosynthesis especially C-1027, neocarzinostatin (NCS), maduropeptin (MDP), calicheamicin (CAL), esperamicin (ESP), and dynemicin (DYN)) biosynthesis will make fundamental contributions to mechanistic ..
  10. GENE EXPRESSION IN NERVOUS TISSUE
    Bruce McEwen; Fiscal Year: 2004
    ..Synapse formation has been demonstrated on CAl neurons using Golgi technique, dye filling of cells, and electron microscopy (EM)...