fatty acid synthase

Summary

Gene Symbol: fatty acid synthase
Description: fatty acid synthase
Alias: FAS, OA-519, SDR27X1, fatty acid synthase, short chain dehydrogenase/reductase family 27X, member 1
Species: human
Products:     fatty acid synthase

Top Publications

  1. Rossi S, Graner E, Febbo P, Weinstein L, Bhattacharya N, Onody T, et al. Fatty acid synthase expression defines distinct molecular signatures in prostate cancer. Mol Cancer Res. 2003;1:707-15 pubmed
    The androgen-regulated enzyme fatty acid synthase (FAS), required for de novo lipogenesis, is overexpressed in several cancers including prostate carcinoma and has been associated with aggressive disease...
  2. Wakil S. Fatty acid synthase, a proficient multifunctional enzyme. Biochemistry. 1989;28:4523-30 pubmed
  3. Kusakabe T, Maeda M, Hoshi N, Sugino T, Watanabe K, Fukuda T, et al. Fatty acid synthase is expressed mainly in adult hormone-sensitive cells or cells with high lipid metabolism and in proliferating fetal cells. J Histochem Cytochem. 2000;48:613-22 pubmed
    Animal fatty acid synthase (FAS) is a homodimer protein which synthesizes long-chain fatty acids and is rich in liver, brain, breast, and lung. However, the precise cellular localization of FAS in human tissues has not been elucidated...
  4. Wang Y, Jones Voy B, Urs S, Kim S, Soltani Bejnood M, Quigley N, et al. The human fatty acid synthase gene and de novo lipogenesis are coordinately regulated in human adipose tissue. J Nutr. 2004;134:1032-8 pubmed
    ..the molecular and mechanistic levels, we studied lipogenesis and the regulation of 1 of its core enzymes, fatty acid synthase (FAS), in human adipose tissue in response to hormonal and nutritional manipulation...
  5. Bandyopadhyay S, Pai S, Watabe M, Gross S, Hirota S, Hosobe S, et al. FAS expression inversely correlates with PTEN level in prostate cancer and a PI 3-kinase inhibitor synergizes with FAS siRNA to induce apoptosis. Oncogene. 2005;24:5389-95 pubmed
    b>Fatty acid synthase (FAS), a key enzyme of the fatty acid biosynthetic pathway, has been shown to be overexpressed in various types of human cancer and is, therefore, considered to be an attractive target for anticancer therapy...
  6. D Erchia A, Tullo A, Lefkimmiatis K, Saccone C, Sbisà E. The fatty acid synthase gene is a conserved p53 family target from worm to human. Cell Cycle. 2006;5:750-8 pubmed
    ..Here, we report that the fatty acid synthase (FAS) gene, encoding for a key enzyme involved in the biogenesis of membrane lipids in rapidly ..
  7. Berndt J, Kovacs P, Ruschke K, Kloting N, Fasshauer M, Schön M, et al. Fatty acid synthase gene expression in human adipose tissue: association with obesity and type 2 diabetes. Diabetologia. 2007;50:1472-80 pubmed
    ..As a central enzyme in lipogenesis, the gene encoding fatty acid synthase (FASN) was identified as a candidate gene for determining body fat...
  8. Vazquez Martin A, Colomer R, Brunet J, Lupu R, Menendez J. Overexpression of fatty acid synthase gene activates HER1/HER2 tyrosine kinase receptors in human breast epithelial cells. Cell Prolif. 2008;41:59-85 pubmed publisher
    ..However, the exact role of the major lipogenic enzyme fatty acid synthase (FASN) as cause, correlate or facilitator of breast cancer remains unidentified...
  9. Ogino S, Nosho K, Meyerhardt J, Kirkner G, Chan A, Kawasaki T, et al. Cohort study of fatty acid synthase expression and patient survival in colon cancer. J Clin Oncol. 2008;26:5713-20 pubmed publisher
    Energy balance seems to be important in the pathogenesis of colon cancer. Fatty acid synthase (FASN) is physiologically regulated by energy balance and is often upregulated in colorectal cancer...

More Information

Publications105 found, 100 shown here

  1. Grunt T, Wagner R, Grusch M, Berger W, Singer C, Marian B, et al. Interaction between fatty acid synthase- and ErbB-systems in ovarian cancer cells. Biochem Biophys Res Commun. 2009;385:454-9 pubmed publisher
    b>Fatty acid synthase (FASN) represents a metabolic oncogene. It produces phospholipids for membrane microdomains that accommodate receptor tyrosine kinases including Epidermal Growth Factor-Receptor (EGFR, ErbB1) and ErbB2 (HER2/neu)...
  2. Zaytseva Y, Rychahou P, Gulhati P, Elliott V, Mustain W, O CONNOR K, et al. Inhibition of fatty acid synthase attenuates CD44-associated signaling and reduces metastasis in colorectal cancer. Cancer Res. 2012;72:1504-17 pubmed publisher
    b>Fatty acid synthase (FASN) and ATP-citrate lyase, key enzymes of de novo lipogenesis, are significantly upregulated and activated in many cancers and portend poor prognosis...
  3. Yang Y, Morin P, Han W, Chen T, Bornman D, Gabrielson E, et al. Regulation of fatty acid synthase expression in breast cancer by sterol regulatory element binding protein-1c. Exp Cell Res. 2003;282:132-7 pubmed
    Activation of fatty acid synthase (FAS) expression and fatty acid synthesis is a common event in human breast cancer...
  4. Joshi A, Zhang L, Rangan V, Smith S. Cloning, expression, and characterization of a human 4'-phosphopantetheinyl transferase with broad substrate specificity. J Biol Chem. 2003;278:33142-9 pubmed
    ..a conserved serine residue in both the acyl carrier protein domain of the human cytosolic multifunctional fatty acid synthase and the acyl carrier protein associated independently with human mitochondria...
  5. de Schrijver E, Brusselmans K, Heyns W, Verhoeven G, Swinnen J. RNA interference-mediated silencing of the fatty acid synthase gene attenuates growth and induces morphological changes and apoptosis of LNCaP prostate cancer cells. Cancer Res. 2003;63:3799-804 pubmed
    b>Fatty acid synthase (FASE), a key enzyme in the biosynthesis of fatty acids, is markedly overexpressed in many human epithelial cancers, rendering it an interesting target for antineoplastic therapy...
  6. Menendez J, Vellon L, Mehmi I, Oza B, Ropero S, Colomer R, et al. Inhibition of fatty acid synthase (FAS) suppresses HER2/neu (erbB-2) oncogene overexpression in cancer cells. Proc Natl Acad Sci U S A. 2004;101:10715-20 pubmed
    b>Fatty acid synthase (FAS) activity is a potential therapeutic target to treat cancer and obesity...
  7. Menendez J, Decker J, Lupu R. In support of fatty acid synthase (FAS) as a metabolic oncogene: extracellular acidosis acts in an epigenetic fashion activating FAS gene expression in cancer cells. J Cell Biochem. 2005;94:1-4 pubmed
    Relatively little information exists on the ultimate molecular mechanisms by which the lipogenic enzyme Fatty Acid Synthase (FAS) is differentially overexpressed in a biologically aggressive subset of human malignancies...
  8. Yoon S, Lee M, Park S, Moon J, Koh Y, Ahn Y, et al. Up-regulation of acetyl-CoA carboxylase alpha and fatty acid synthase by human epidermal growth factor receptor 2 at the translational level in breast cancer cells. J Biol Chem. 2007;282:26122-31 pubmed
    ..increased in approximately 30% of human breast carcinomas and is closely correlated with the expression of fatty acid synthase (FASN)...
  9. Furuta E, Pai S, Zhan R, Bandyopadhyay S, Watabe M, Mo Y, et al. Fatty acid synthase gene is up-regulated by hypoxia via activation of Akt and sterol regulatory element binding protein-1. Cancer Res. 2008;68:1003-11 pubmed publisher
    The fatty acid synthase (FAS) gene is significantly up-regulated in various types of cancers, and blocking the FAS expression results in apoptosis of tumor cells...
  10. Silva S, Cunha I, Rangel A, Jorge J, Zecchin K, Agostini M, et al. Differential expression of fatty acid synthase (FAS) and ErbB2 in nonmalignant and malignant oral keratinocytes. Virchows Arch. 2008;453:57-67 pubmed publisher
    The aim of this study was to investigate fatty acid synthase (FAS) and ErbB2 expression in nonmalignant oral epithelium and oral or head and neck squamous cell carcinomas (OSCC/HNSCC)...
  11. Fiorentino M, Zadra G, Palescandolo E, Fedele G, Bailey D, Fiore C, et al. Overexpression of fatty acid synthase is associated with palmitoylation of Wnt1 and cytoplasmic stabilization of beta-catenin in prostate cancer. Lab Invest. 2008;88:1340-8 pubmed publisher
    b>Fatty acid synthase (FASN), a key metabolic enzyme for liponeogenesis highly expressed in several human cancers, displays oncogenic properties such as resistance to apoptosis and induction of proliferation when overexpressed...
  12. Oliveras Ferraros C, Vazquez Martin A, Fernandez Real J, Menendez J. AMPK-sensed cellular energy state regulates the release of extracellular Fatty Acid Synthase. Biochem Biophys Res Commun. 2009;378:488-93 pubmed publisher
    b>Fatty Acid Synthase (FASN), a 250-kDa cytosolic multi-enzyme catalyzing eukaryotic de novo FA biogenesis, unexpectedly localizes in cancer cell culture supernatants and in the blood of cancer patients...
  13. Migita T, Ruiz S, Fornari A, Fiorentino M, Priolo C, Zadra G, et al. Fatty acid synthase: a metabolic enzyme and candidate oncogene in prostate cancer. J Natl Cancer Inst. 2009;101:519-32 pubmed publisher
    Overexpression of the fatty acid synthase (FASN) gene has been implicated in prostate carcinogenesis. We sought to directly assess the oncogenic potential of FASN...
  14. Rahman M, Nakayama K, Rahman M, Katagiri H, Katagiri A, Ishibashi T, et al. Fatty acid synthase expression associated with NAC1 is a potential therapeutic target in ovarian clear cell carcinomas. Br J Cancer. 2012;107:300-7 pubmed publisher
    ..examined the clinical significance of NAC1 and the expression level of its potential downstream target fatty acid synthase (FASN) in ovarian clear cell carcinomas (OCCCs), and evaluated the NAC1/FASN pathway as a potential ..
  15. Li N, Lu H, Chen C, Bu X, Huang P. Loss of fatty acid synthase inhibits the "HER2-PI3K/Akt axis" activity and malignant phenotype of Caco-2 cells. Lipids Health Dis. 2013;12:83 pubmed publisher
    b>Fatty acid synthase (FASN) is frequently activated and overexpressed in human cancers, and plays a crucial role in the carcinogenesis of various cancers...
  16. Dong L, Han X, Tao X, Xu L, Xu Y, Fang L, et al. Protection by the Total Flavonoids from Rosa laevigata Michx Fruit against Lipopolysaccharide-Induced Liver Injury in Mice via Modulation of FXR Signaling. Foods. 2018;7: pubmed publisher
    ..levels of SREBP-1c (sterol regulatory element-binding proteins-1c), ACC1 (acetyl-CoA carboxylase-1), FASN (fatty acid synthase), and SCD1 (stearoyl-coenzyme A desaturase 1), and improved CPT1 (carnitine palmitoyltransferase 1) level ..
  17. Zhao Z, Barcus M, Kim J, Lum K, Mills C, Lei X. High Dietary Selenium Intake Alters Lipid Metabolism and Protein Synthesis in Liver and Muscle of Pigs. J Nutr. 2016;146:1625-33 pubmed publisher
    ..lipogenesis [sterol regulatory element binding protein 1 (SREBP1), acetyl-coenzyme A carboxylase (ACC), and fatty acid synthase (FASN); 46-90%], protein synthesis [insulin receptor (INSR), P70 ribosomal protein S6 kinase (P70), and ..
  18. Lim E, Lim J, Kim E, Kim Y, Shin J, Seok P, et al. Xylobiose, an Alternative Sweetener, Ameliorates Diabetes-Related Metabolic Changes by Regulating Hepatic Lipogenesis and miR-122a/33a in db/db Mice. Nutrients. 2016;8: pubmed
    ..In the liver, expressions of the lipogenic genes, including, fatty acid synthase (FAS), peroxisome proliferator activated receptor ? (PPAR?), sterol regulatory element-binding protein-1C (..
  19. Park S, Sung Y, Jang S, Nho K, Choi G, Kim H. The Korean herbal medicine, Do In Seung Gi-Tang, attenuates atherosclerosis via AMPK in high-fat diet-induced ApoE(-/-) mice. BMC Complement Altern Med. 2016;16:352 pubmed publisher
    ..intercellular adhesion molecule-1 [ICAM-1], vascular cell adhesion molecule-1 [VCAM-1], and E-selectin), fatty acid synthase (FAS), adenosine monophosphate-activated protein kinase (AMPK), and acetyl-coA carboxylase (ACC) in the ..
  20. Veeramani C, Alsaif M, Al Numair K. Lavatera critica, a green leafy vegetable, controls high fat diet induced hepatic lipid accumulation and oxidative stress through the regulation of lipogenesis and lipolysis genes. Biomed Pharmacother. 2017;96:1349-1357 pubmed publisher
    ..palmitoyltransferase-1 (CPT-1), and acetyl-CoA carboxylase (ACO), and fatty acid synthesis genes such as fatty acid synthase (FAS), sterol-regulatory-element-binding protein-1c (SREBP-1c), and acetyl-CoA carboxylase (ACC)...
  21. Pan Y, Luo Z, Zhuo M, Wei C, Chen G, Song Y. Oxidative stress and mitochondrial dysfunction mediated Cd-induced hepatic lipid accumulation in zebrafish Danio rerio. Aquat Toxicol. 2018;199:12-20 pubmed publisher
    ..CdCl2 exposure increased hepatic triglyceride (TG) and Cd accumulation, the activities of fatty acid synthase (FAS), 6-phosphogluconate dehydrogenase (6PGD), glucose 6-phosphate dehydrogenase (G6PD) and malic enzyme (..
  22. Tian J, Wu F, Yang C, Jiang M, Liu W, Wen H. Dietary lipid levels impact lipoprotein lipase, hormone-sensitive lipase, and fatty acid synthetase gene expression in three tissues of adult GIFT strain of Nile tilapia, Oreochromis niloticus. Fish Physiol Biochem. 2015;41:1-18 pubmed publisher
    ..In the lipid-fed groups, there was a significant down-regulation of fatty acid synthase (FAS) mRNA in liver, muscle, and visceral adipose tissues...
  23. Sun J, Liu X, Cong L, Li H, Zhang C, Chen J, et al. Metabolomics study of the therapeutic mechanism of Schisandra Chinensis lignans in diet-induced hyperlipidemia mice. Lipids Health Dis. 2017;16:145 pubmed publisher
    ..SCL significantly inhibited the mRNA expression level of hepatic lipogenesis genes such as SREBP-1c, fatty acid synthase (FAS) and acetyl-CoA carboxylase (ACC), and decreased the mRNA expression of liver X receptor α (LXRα)..
  24. Venza M, Visalli M, Oteri R, Agliano F, Morabito S, Teti D, et al. The overriding of TRAIL resistance by the histone deacetylase inhibitor MS-275 involves c-myc up-regulation in cutaneous, uveal, and mucosal melanoma. Int Immunopharmacol. 2015;28:313-21 pubmed publisher
    ..inhibitor (HDACi) MS-275 was a privileged way to override TRAIL resistance through down-regulation of cellular Fas-associated death domain (FADD)-like interleukin-1beta-converting enzyme-inhibitory protein (c-FLIP)...
  25. Sepa Kishi D, Wu M, Uthayakumar A, Mohasses A, Ceddia R. Antilipolytic and antilipogenic effects of the CPT-1b inhibitor oxfenicine in the white adipose tissue of rats. Am J Physiol Regul Integr Comp Physiol. 2016;311:R779-R787 pubmed publisher
    ..Because the white adipose tissue (WAT) is an organ that stores and releases FAs, this study investigated whether oxfenicine-induced inhibition of FA oxidation affected adiposity and WAT ..
  26. Jayamani J, Naisini A, Madhan B, Shanmugam G. Ferulic acid, a natural phenolic compound, as a potential inhibitor for collagen fibril formation and its propagation. Int J Biol Macromol. 2018;113:277-284 pubmed publisher
    ..Saturation Transfer Difference NMR suggests that FAs are in proximity to collagen while fluorescence quenching upon addition of FA proposes that FA most likely binds to ..
  27. Park J, Park S, Wu H, Kim J. Improvement of VMAT plan quality for head and neck cancer with high resolution fluences generated by couch shift between arcs. Phys Med. 2018;46:1-6 pubmed publisher
    ..NS plan), a two-half-arc-pair plan with couch-shift (HAS plan), and a two-full-arc pair plan with couch-shift (FAS plan). Changes in the dose-volumetric parameters were investigated...
  28. Jones A, Trujillo K, Phillips G, Fleet T, Murton J, Severns V, et al. Early growth response 1 and fatty acid synthase expression is altered in tumor adjacent prostate tissue and indicates field cancerization. Prostate. 2012;72:1159-70 pubmed publisher
    ..up-regulated mRNA of the transcription factor early growth response 1 (EGR-1) and the lipogenic enzyme fatty acid synthase (FAS) in tissues adjacent to prostate cancer...
  29. Dua T, Dewanjee S, Khanra R, Bhattacharya N, Bhaskar B, Zia Ul Haq M, et al. The effects of two common edible herbs, Ipomoea aquatica and Enhydra fluctuans, on cadmium-induced pathophysiology: a focus on oxidative defence and anti-apoptotic mechanism. J Transl Med. 2015;13:245 pubmed publisher
    ..05-0.01) with ROS mediated alteration of transcription levels of signal proteins viz. Bcl-2, BAD, Cyt-C, Caspases, Fas and Bid...
  30. Veenstra J, Kalsbeek A, Westra J, Disselkoen C, Smith C, Tintle N. Genome-Wide Interaction Study of Omega-3 PUFAs and Other Fatty Acids on Inflammatory Biomarkers of Cardiovascular Health in the Framingham Heart Study. Nutrients. 2017;9: pubmed publisher
    ..5 million single nucleotide polymorphisms (SNPs) and 22 RBC FAs (and associated ratios), including the four Omega-3 FAs (ALA, DHA, DPA, and EPA)...
  31. Al Qahtani A, Holly J, Perks C. Hypoxia negates hyperglycaemia-induced chemo-resistance in breast cancer cells: the role of insulin-like growth factor binding protein 2. Oncotarget. 2017;8:74635-74648 pubmed publisher
    ..We have shown that hyperglycaemia induces resistance to chemotherapy through upregulation of fatty acid synthase (FASN) in breast cancer cells and increased insulin-like binding protein 2 (IGFBP-2) in prostate cancer ..
  32. Jayaratne E, Wijeratne D, Fernando S, Kamaladasa A, Gomes L, Wijewickrama A, et al. Regulatory T cells in acute dengue viral infection. Immunology. 2017;: pubmed publisher
    ..different subset of T cells and their suppressive potential was assessed by their expression of CTLA-4 and Fas. While the frequency of FOXP3+ cells, in patients was significantly higher (p<0...
  33. Yu Z, Wu F, Tian J, Guo X, An R, Guo Y. Ammonium glycyrrhizin counteracts liver injury caused by lipopolysaccharide/amoxicillin-clavulanate potassium. Oncotarget. 2017;8:96837-96851 pubmed publisher
    ..that CAG treatment downregulated LPS/AC-induced RNA expression of caspase-3, caspase-9, bax, cytochrome c, and fas, and upregulated the expression of bcl-2...
  34. Lee Y, Choi H, Seo M, Jeon H, Kim K, Lee B. Kaempferol suppresses lipid accumulation by inhibiting early adipogenesis in 3T3-L1 cells and zebrafish. Food Funct. 2015;6:2824-33 pubmed publisher
    ..These results were supported in zebrafish based on the decrease in lipid accumulation and expression of adipogenic factors. Our results indicated that kaempferol might have an anti-obesity effect by regulating lipid metabolism. ..
  35. Nie F, Liang Y, Jiang B, Li X, Xun H, He W, et al. Apoptotic effect of tannic acid on fatty acid synthase over-expressed human breast cancer cells. Tumour Biol. 2016;37:2137-43 pubmed publisher
    ..Increasing evidence suggests that fatty acid synthase (FAS) plays an important role in breast cancer, for the expression of FAS is significantly higher in human ..
  36. Meng H, Li X, Chen Y, Yu L, Zhang H, Lao J, et al. Neuronal Soluble Fas Ligand Drives M1-Microglia Polarization after Cerebral Ischemia. CNS Neurosci Ther. 2016;22:771-81 pubmed publisher
    ..Ischemic neurons release sFasL, which contributes to M1-microglial polarization. The underlying mechanisms may involve the activation of JAK2/STAT3 and NF-?B signaling pathways. ..
  37. Saavedra García P, Nichols K, Mahmud Z, Fan L, Lam E. Unravelling the role of fatty acid metabolism in cancer through the FOXO3-FOXM1 axis. Mol Cell Endocrinol. 2018;462:82-92 pubmed publisher
    ..There is an extensive overlap in their signalling pathways and molecular components involved such as fatty acids (FAs), which likely play a crucial role in cancer...
  38. Jiang M, Lyu Q, Bai Y, Liu H, Yang J, Cheng J, et al. Focal adhesions are involved in simulated-microgravity-induced basilar and femoral arterial remodelling in rats. Can J Physiol Pharmacol. 2018;96:772-782 pubmed publisher
    ..Focal adhesions (FAs) are dynamic protein complexes that have mechanotransduction properties...
  39. Cinelli G, Fabrizi M, Rava L, Signore F, Vernocchi P, Semeraro M, et al. Association between Maternal and Foetal Erythrocyte Fatty Acid Profiles and Birth Weight. Nutrients. 2018;10: pubmed publisher
    ..The quality and quantity of maternal dietary fatty acids (FAs) can affect growth...
  40. Lin Y, Yen C, Chen H, Liao Y, Lin I, Chen M, et al. The serologic decoy receptor 3 (DcR3) levels are associated with slower disease progression in HIV-1/AIDS patients. J Formos Med Assoc. 2015;114:498-503 pubmed publisher
    ..It counteracts the biological effects of Fas ligands and inhibits apoptosis...
  41. Creus A, Ferreira M, Oliva M, Lombardo Y. Mechanisms Involved in the Improvement of Lipotoxicity and Impaired Lipid Metabolism by Dietary α-Linolenic Acid Rich Salvia hispanica L (Salba) Seed in the Heart of Dyslipemic Insulin-Resistant Rats. J Clin Med. 2016;5: pubmed publisher
    ..Normalization of dyslipidemia and IR by chia reduces plasma fatty acids (FAs) availability, suggesting that a different milieu prevents the robust translocation of FAT/CD36...
  42. Albiges L, Hakimi A, Xie W, McKay R, Simantov R, Lin X, et al. Body Mass Index and Metastatic Renal Cell Carcinoma: Clinical and Biological Correlations. J Clin Oncol. 2016;: pubmed
    ..fatty acid metabolism pathway, in The Cancer Genome Atlas data set, and immunohistochemistry staining for fatty acid synthase (FASN) were also investigated...
  43. Choi Y, Abdelmegeed M, Song B. Preventive effects of dietary walnuts on high-fat-induced hepatic fat accumulation, oxidative stress and apoptosis in mice. J Nutr Biochem. 2016;38:70-80 pubmed publisher
    ..prevented HFD-mediated alteration of the levels of key proteins in lipid homeostasis such as Sirt1, AMPK and FAS, leading to decreased fat accumulation...
  44. Pradhan A, Hammerquist A, Khanna A, Curran S. The C-Box Region of MAF1 Regulates Transcriptional Activity and Protein Stability. J Mol Biol. 2017;429:192-207 pubmed publisher
    ..Our results reveal a role for the C-box region as a critical determinant of MAF1 stability, activity, and response to cellular stress. ..
  45. Gajate C, Mollinedo F. Lipid raft-mediated Fas/CD95 apoptotic signaling in leukemic cells and normal leukocytes and therapeutic implications. J Leukoc Biol. 2015;98:739-59 pubmed publisher
    ..of evidence has also identified raft platforms as scaffolds for the recruitment and clustering of death receptor Fas/CD95 and downstream signaling molecules, leading to the concept of death-promoting lipid rafts...
  46. Bennett L, Anderson R. Current Progress in Deciphering Importance of VLC-PUFA in the Retina. Adv Exp Med Biol. 2016;854:145-51 pubmed publisher
    ..This gene product catalyzes the elongation of long chain saturated and polyunsaturated fatty acids (LC-FAs and LC-PUFAs) into very long chain FAs and PUFAs (VLC-FAs and VLC-PUFAs)...
  47. Zhou D, Li B, Wang J, Ding Y, Dong Y, Chen Y, et al. Prolyl Oligopeptidase Inhibition Attenuates Steatosis in the L02 Human Liver Cell Line. PLoS ONE. 2016;11:e0165224 pubmed publisher
    ..The expression of POP increases with hepatocyte steatosis, and POP inhibitors can significantly reduce intracellular lipid accumulation, which might be related to the inhibition of genes involved in lipid synthesis. ..
  48. Fodor R, Georgescu A, Grigorescu B, Cioc A, Veres M, Cotoi O, et al. Caspase 3 expression and plasma level of Fas ligand as apoptosis biomarkers in inflammatory endotoxemic lung injury. Rom J Morphol Embryol. 2016;57:951-957 pubmed
    ..this study is to evaluate if the immunohistochemical expression of a pulmonary apoptosis marker and plasma level of Fas ligand (FasL) correlates with the dose- and time-dependent severity of lung injury, induced by the administration ..
  49. Guo J, Kim N, Cui X. Inhibition of Fatty Acid Synthase Reduces Blastocyst Hatching through Regulation of the AKT Pathway in Pigs. PLoS ONE. 2017;12:e0170624 pubmed publisher
    b>Fatty acid synthase (FASN) is an enzyme responsible for the de novo synthesis of long-chain fatty acids. During oncogenesis, FASN plays a role in growth and survival rather than acting within the energy storage pathways...
  50. Jin C, Luo T, Zhu Z, Pan Z, Yang J, Wang W, et al. Imazalil exposure induces gut microbiota dysbiosis and hepatic metabolism disorder in zebrafish. Comp Biochem Physiol C Toxicol Pharmacol. 2017;202:85-93 pubmed publisher
    ..the transcription of some genes related to glycolysis and lipid metabolism, including Aco, Cpt1, Acc1, Srebp1a and Fas, was decreased significantly in the liver of zebrafish when exposed to 100 and 1000?g/L IMZ for 7 or 21days...
  51. Strieder Barboza C, de Souza J, Raphael W, Lock A, Contreras G. Fetuin-A: A negative acute-phase protein linked to adipose tissue function in periparturient dairy cows. J Dairy Sci. 2018;101:2602-2616 pubmed publisher
    ..Overall, FetA is a systemic and local AT negative acute-phase protein linked to AT function in periparturient cows. Furthermore, FetA may support physiological adaptations to NEB in periparturient cows. ..
  52. Yang X, Tietje A, Yu X, Wei Y. Mouse interleukin-12/FasTI: A novel bi-functional fusion protein for cancer immuno/gene therapy. Int J Oncol. 2016;48:2381-6 pubmed publisher
    ..challenge is that advanced tumor cells often evade immunosurveillance of the immune system as well as of the Fas-mediated apoptosis by various mechanisms...
  53. Keatinge Clay A. The Structural Relationship between Iterative and Modular PKSs. Cell Chem Biol. 2016;23:540-542 pubmed publisher
    ..2016). Beyond sharing a structural similarity with the mammalian fatty acid synthase (FAS), the authors argue that the MAS architecture is representative of some PKS modules.
  54. Ali A, Moss C, Yoo M, Wilkinson A, Breier B. Effect of mouth rinsing and ingestion of carbohydrate solutions on mood and perceptual responses during exercise. J Int Soc Sports Nutr. 2017;14:4 pubmed publisher
    ..Perceptual scales were used to assess affective valence (feeling scale, FS), arousal (felt arousal scale, FAS), exertion (ratings of perceived exertion, RPE) and mood (profile of mood states, POMS) before, during and ..
  55. Buckley D, Duke G, Heuer T, O Farrell M, Wagman A, McCulloch W, et al. Fatty acid synthase - Modern tumor cell biology insights into a classical oncology target. Pharmacol Ther. 2017;177:23-31 pubmed publisher
    Decades of preclinical and natural history studies have highlighted the potential of fatty acid synthase (FASN) as a bona fide drug target for oncology...
  56. Li C, Fang F, Chen Y, Liu T, Chan T, Yu S, et al. Overexpressed Fatty Acid Synthase in Gastrointestinal Stromal Tumors: Targeting a Progression-Associated Metabolic Driver Enhances the Antitumor Effect of Imatinib. Clin Cancer Res. 2017;23:4908-4918 pubmed publisher
    ..In gastrointestinal stromal tumors (GIST), lipid-metabolizing enzymes remain underexplored, including fatty acid synthase (FASN).Experimental Design: Forty GISTs were quantitated for FASN mRNA abundance...
  57. Guegan J, Legembre P. Nonapoptotic functions of Fas/CD95 in the immune response. FEBS J. 2018;285:809-827 pubmed publisher
    CD95 (also known as Fas) is a member of the tumor necrosis factor receptor (TNFR) superfamily. Its cognate ligand, CD95L, is implicated in immune homeostasis and immune surveillance...
  58. Pino A, Rodríguez J. Is fatty acid composition of human bone marrow significant to bone health?. Bone. 2019;118:53-61 pubmed publisher
    ..Both saturated and unsaturated FAs originate lipid species which are active mediators in the inflammation process...
  59. Angeles T, Hudkins R. Recent advances in targeting the fatty acid biosynthetic pathway using fatty acid synthase inhibitors. Expert Opin Drug Discov. 2016;11:1187-1199 pubmed
    ..b>Fatty acid synthase (FASN) plays a pivotal role in de novo lipogenesis, making this multi-catalytic protein an attractive ..
  60. Haga S, Yimin -, Ozaki M. Relevance of FXR-p62/SQSTM1 pathway for survival and protection of mouse hepatocytes and liver, especially with steatosis. BMC Gastroenterol. 2017;17:9 pubmed publisher
    ..of Akt, expression of the anti-apoptotic molecules (Bcl-xL and Bcl-2), and reduced harmful hepatic molecules (Fas ligand and Fas). GW4064 promoted hepatocyte survival, which was cancelled by p62/SQSTM1 siRNA...
  61. Park S, Paik Y. Genetic deficiency in neuronal peroxisomal fatty acid β-oxidation causes the interruption of dauer development in Caenorhabditis elegans. Sci Rep. 2017;7:9358 pubmed publisher
    ..Un-metabolized FAs accumulated in ASK neurons of daf-22 mutants stimulate the endoplasmic reticulum (ER) stress response, which may ..
  62. Bo L, Zhu X, Zheng Z, Hu X, Chen P. Research on the function and mechanism of survivin in heart failure mice model. Eur Rev Med Pharmacol Sci. 2017;21:3699-3704 pubmed
    ..The mRNA expressions of tumor necrosis factor-? (TNF-?), factor associated suicide (Fas) and factor associated suicide ligand (FasL) were detected via reverse transcription polymerase chain reaction (RT-..
  63. Chen G, Hogstrand C, Luo Z, Zhang D, Ling S, Wu K. Dietary zinc addition influenced zinc and lipid deposition in the fore- and mid-intestine of juvenile yellow catfish Pelteobagrus fulvidraco. Br J Nutr. 2017;118:570-579 pubmed publisher
    ..of 6-phosphogluconate dehydrogenase (6PGD), glucose-6-phosphate dehydrogenase (G6PD), malic enzyme (ME) and fatty acid synthase (FAS) activities, and reduced mRNA levels of 6PGD, G6PD, FAS, PPAR? and sterol-regulator element-binding ..
  64. Deschout H, Platzman I, Sage D, Feletti L, Spatz J, Radenovic A. Investigating Focal Adhesion Substructures by Localization Microscopy. Biophys J. 2017;113:2508-2518 pubmed publisher
    Cells rely on focal adhesions (FAs) to carry out a variety of important tasks, including motion, environmental sensing, and adhesion to the extracellular matrix...
  65. Jones B, Kim J, Zemel M, Woychik R, Michaud E, Wilkison W, et al. Upregulation of adipocyte metabolism by agouti protein: possible paracrine actions in yellow mouse obesity. Am J Physiol. 1996;270:E192-6 pubmed
    ..To further characterize this model, we analyzed adipose and hepatic mRNA levels for fatty acid synthase (FAS) and stearoyl-CoA desaturase (SCD), two key enzymes in de novo fatty acid synthesis and desaturation, ..
  66. Huang X, Jiang D, Zhu Y, Fang Z, Che L, Lin Y, et al. Chronic High Dose Zinc Supplementation Induces Visceral Adipose Tissue Hypertrophy without Altering Body Weight in Mice. Nutrients. 2017;9: pubmed publisher
    ..marker genes and lipogenic genes were not affected by chronic zinc supplementation, but the protein levels of FAS and SCD1 decreased or tended to decrease in the perirenal adipose tissue of zinc-supplemented mice, as compared to ..
  67. Spratte J, Princk H, Schütz F, Rom J, Zygmunt M, Fluhr H. Stimulation of chemokines in human endometrial stromal cells by tumor necrosis factor-α and interferon-γ is similar under apoptotic and non-apoptotic conditions. Arch Gynecol Obstet. 2018;297:505-512 pubmed publisher
    ..Both cytokines in combination are able to sensitize primarily resistant human endometrial stromal cells (ESCs) to Fas-induced apoptosis...
  68. Chen Y, Liu W, Qin H, Han H. [Transcriptional activities of human fatty acid synthase promoter in breast cancer cells]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2007;23:429-31 pubmed
    To analyse the transcriptional activities of human fatty acid synthase (FAS) promoter in breast cancer cell lines and normal fibroblast cell line in order to provide some theoretical evidence for the targeted therapy of breast cancer...
  69. Silva S, Perez D, Nishimoto I, Alves F, Pinto C, Kowalski L, et al. Fatty acid synthase expression in squamous cell carcinoma of the tongue: clinicopathological findings. Oral Dis. 2008;14:376-82 pubmed publisher
    Overexpression of fatty acid synthase (FAS), the cytosolic enzyme responsible for the conversion of dietary carbohydrates to fatty acids, has been reported in several human malignancies and pointed as a potential prognostic marker for ..
  70. Prats Puig A, Puig T, Sitjar C, Mas Parareda M, Grau Cabrera P, Soriano Rodríguez P, et al. Soluble fatty acid synthase relates to bone biomarkers in prepubertal children. Osteoporos Int. 2012;23:2053-8 pubmed publisher
    Circulating soluble fatty acid synthase (FASN, a key enzyme in de novo biosynthesis of fatty acids, expressed in both adipocytes and osteoblasts) is clinically related to a less favorable bone profile in healthy prepubertal children...
  71. Santolla M, Lappano R, De Marco P, Pupo M, Vivacqua A, Sisci D, et al. G protein-coupled estrogen receptor mediates the up-regulation of fatty acid synthase induced by 17?-estradiol in cancer cells and cancer-associated fibroblasts. J Biol Chem. 2012;287:43234-45 pubmed publisher
    Activation of lipid metabolism is an early event in carcinogenesis and a central hallmark of many tumors. Fatty acid synthase (FASN) is a key lipogenic enzyme catalyzing the terminal steps in the de novo biogenesis of fatty acids...
  72. Gilbert S, Loranger A, Omary M, Marceau N. Keratin impact on PKC?- and ASMase-mediated regulation of hepatocyte lipid raft size - implication for FasR-associated apoptosis. J Cell Sci. 2016;129:3262-73 pubmed publisher
    ..reported that a K8/K18 loss in hepatocytes leads to altered cell surface lipid raft distribution and more efficient Fas receptor (FasR, also known as TNFRSF6)-mediated apoptosis...
  73. Zhu M, Harshbarger W, Robles O, Krysiak J, Hull K, Cho S, et al. A strategy for dual inhibition of the proteasome and fatty acid synthase with belactosin C-orlistat hybrids. Bioorg Med Chem. 2017;25:2901-2916 pubmed publisher
    ..proteasome, a validated cellular target for cancer, is central for maintaining cellular homeostasis, while fatty acid synthase (FAS), a novel target for numerous cancers, is responsible for palmitic acid biosynthesis...
  74. Xu H, Luo J, Ma G, Zhang X, Yao D, Li M, et al. Acyl-CoA synthetase short-chain family member 2 (ACSS2) is regulated by SREBP-1 and plays a role in fatty acid synthesis in caprine mammary epithelial cells. J Cell Physiol. 2018;233:1005-1016 pubmed publisher
    ..Taken together, our results revealed a novel pathway that SREBP-1 may regulate fatty acid and TAG synthesis by regulating the expression of ACSS2. ..
  75. Pereira M, Ferreira L, da Silva F, Christoffolete M, Metsios G, Chaves V, et al. A low-protein, high-carbohydrate diet increases browning in perirenal adipose tissue but not in inguinal adipose tissue. Nutrition. 2017;42:37-45 pubmed publisher
    The aim of this study was to evaluate the browning and origin of fatty acids (FAs) in the maintenance of triacylglycerol (TG) storage and/or as fuel for thermogenesis in perirenal adipose tissue (periWAT) and inguinal adipose tissue (..
  76. Walz J, Saha J, Arora A, Khammanivong A, O Sullivan M, Dickerson E. Fatty acid synthase as a potential therapeutic target in feline oral squamous cell carcinoma. Vet Comp Oncol. 2018;16:E99-E108 pubmed publisher
    ..Recent work has demonstrated aberrant expression of fatty acid synthase (FASN) and an increased capacity for lipogenesis in human OSCC and other cancers...
  77. Park Y, Obiang Obounou B, Lee J, Lee T, Bae M, Hwang K, et al. Anti-Adipogenic Effects on 3T3-L1 Cells and Zebrafish by Tanshinone IIA. Int J Mol Sci. 2017;18: pubmed publisher
    ..of CCAAT/enhancer-binding protein-? (C/EBP-?), peroxisome proliferator-activated receptor-? (PPAR-?), fatty acid synthase (FAS), and perilipin A but also the phosphorylation levels of signal transducer and activator of ..
  78. Pradhan A, Olsson P, Jass J. Di(2-ethylhexyl) phthalate and diethyl phthalate disrupt lipid metabolism, reduce fecundity and shortens lifespan of Caenorhabditis elegans. Chemosphere. 2018;190:375-382 pubmed publisher
    ..elegans, however its substitute DEP has not been previously tested in this model organism and our data revealed that DEP is equally potent as DEHP in regulating C. elegans physiological functions. ..
  79. Zhu J, Powis de Tenbossche C, Cane S, Colau D, van Baren N, Lurquin C, et al. Resistance to cancer immunotherapy mediated by apoptosis of tumor-infiltrating lymphocytes. Nat Commun. 2017;8:1404 pubmed publisher
    ..Apoptosis of tumor-infiltrating lymphocytes can be prevented by interrupting the Fas/Fas-ligand axis, and is triggered by polymorphonuclear-myeloid-derived suppressor cells, which express high levels ..
  80. Hu T, Fei Z, Wei N. Chemosensitive effects of Astragaloside IV in osteosarcoma cells via induction of apoptosis and regulation of caspase-dependent Fas/FasL signaling. Pharmacol Rep. 2017;69:1159-1164 pubmed publisher
    ..Caspase-dependent Fas/FasL signaling was involved in cisplatin-induced apoptosis which was enhanced by Astragaloside IV...
  81. She K, Yan H, Huang J, Zhou H, He J. miR-193b availability is antagonized by LncRNA-SNHG7 for FAIM2-induced tumour progression in non-small cell lung cancer. Cell Prolif. 2018;51: pubmed publisher
    ..We previously found that up-regulated LncRNA-SNHG7 (SNHG7) positively correlated to the Fas apoptosis inhibitory molecule 2 (FAIM2) in lung cancer cells with unclear mechanism...
  82. Rochat Steiner V, Becker K, Micheau O, Schneider P, Burns K, Tschopp J. FIST/HIPK3: a Fas/FADD-interacting serine/threonine kinase that induces FADD phosphorylation and inhibits fas-mediated Jun NH(2)-terminal kinase activation. J Exp Med. 2000;192:1165-74 pubmed
    b>Fas is a cell surface death receptor that signals apoptosis. Several proteins have been identified that bind to the cytoplasmic death domain of Fas...
  83. Chakravarty B, Gu Z, Chirala S, Wakil S, Quiocho F. Human fatty acid synthase: structure and substrate selectivity of the thioesterase domain. Proc Natl Acad Sci U S A. 2004;101:15567-72 pubmed
    Human fatty acid synthase is a large homodimeric multifunctional enzyme that synthesizes palmitic acid...
  84. Orita H, Coulter J, Tully E, Abe M, Montgomery E, Alvarez H, et al. High levels of fatty acid synthase expression in esophageal cancers represent a potential target for therapy. Cancer Biol Ther. 2010;10:549-54 pubmed publisher
    b>Fatty acid synthase (FAS) is overexpressed in many human cancers and is considered to be a promising target for therapy...
  85. Du J, Peng R, Xu D, Zhao T, Shen L, Zhao S. [Effects of soluble epoxide hydrolase inhibitors on the expression of fatty acid synthase in peripheral blood mononuclear cell of patients and inflammatory response with acute coronary syndrome]. Zhonghua Yi Xue Za Zhi. 2012;92:86-90 pubmed
    To explore the effects of soluble epoxide hydrolase inhibitor (sEHi) on the expressions of fatty acid synthase (FASN) mRNA and protein in peripheral blood mononuclear cell (PBMCs) of patients with acute coronary syndrome (ACS) and to ..
  86. Verescakova H, Ambrozova G, Kubala L, Perecko T, Koudelka A, Vašíček O, et al. Nitro-oleic acid regulates growth factor-induced differentiation of bone marrow-derived macrophages. Free Radic Biol Med. 2017;104:10-19 pubmed publisher
    ..Recently, we reported that nitro-fatty acids (NO2-FAs), products of metabolic and inflammatory reactions of nitric oxide and nitrite, modulate macrophage and other ..
  87. Ahmad F, Patrick S, Sheikh T, Sharma V, Pathak P, Malgulwar P, et al. Telomerase reverse transcriptase (TERT) - enhancer of zeste homolog 2 (EZH2) network regulates lipid metabolism and DNA damage responses in glioblastoma. J Neurochem. 2017;143:671-683 pubmed publisher
    ..By bringing TERT-EZH2 network at the forefront as driver of dysregulated metabolism, our findings highlight the non-canonical but distinct role of TERT in metabolic reprogramming and DNA damage responses in glioblastoma. ..
  88. Arcidiacono P, Ragonese F, Stabile A, Pistilli A, Kuligina E, Rende M, et al. Antitumor activity and expression profiles of genes induced by sulforaphane in human melanoma cells. Eur J Nutr. 2018;57:2547-2569 pubmed publisher
    ..SFN upregulated the expression of pro-apoptotic genes, such as p53, BAX, PUMA, FAS and MDM2; promoted cell cycle inhibition and growth arrest by upregulating EGR1, GADD45B, ATF3 and CDKN1A; and ..
  89. Le Gallo M, Poissonnier A, Blanco P, Legembre P. CD95/Fas, Non-Apoptotic Signaling Pathways, and Kinases. Front Immunol. 2017;8:1216 pubmed publisher
    ..The receptor CD95 (also named Fas or apoptosis antigen 1) belongs to the tumor necrosis factor (TNF) receptor superfamily...
  90. Rieux Laucat F. What's up in the ALPS. Curr Opin Immunol. 2017;49:79-86 pubmed publisher
    ..entity was recognized in the mid 60s and its genetic etiology was described in 1995 by the discovery of the FAS gene mutations...
  91. Zhou H, Cui X, Yuan H, Zhang B, Meng C, Zhao D. Effects of distinct drugs on gene transcription in an osteosarcoma cell line. Oncol Lett. 2017;14:4694-4700 pubmed publisher
    ..Several common DEGs including MDM2, TP53I3, RRM2B, FAS and SESN1 were targeted by all the drugs with the exception of DMSO...
  92. Lu L, Wang M, Liao X, Zhang L, Luo X. Manganese influences the expression of fatty acid synthase and malic enzyme in cultured primary chicken hepatocytes. Br J Nutr. 2017;118:881-888 pubmed publisher
    ..investigate the effects of Mn source and concentration on the mRNA expression and enzymatic activities of fatty acid synthase (FAS) and malic enzyme (ME) in cultured primary broiler hepatocytes...