fascin

Summary

Gene Symbol: fascin
Description: fascin actin-bundling protein 1
Alias: FAN1, HSN, SNL, p55, fascin, 55 kDa actin-bundling protein, fascin homolog 1, actin-bundling protein, singed-like (fascin homolog, sea urchin)
Species: human
Products:     fascin

Top Publications

  1. Yamakita Y, Ono S, Matsumura F, Yamashiro S. Phosphorylation of human fascin inhibits its actin binding and bundling activities. J Biol Chem. 1996;271:12632-8 pubmed
    Human fascin is an actin-bundling protein that is thought to be involved in the assembly of actin filament bundles present in microspikes as well as in membrane ruffles and stress fibers...
  2. Hanker L, Karn T, Holtrich U, Graeser M, Becker S, Reinhard J, et al. Prognostic impact of fascin-1 (FSCN1) in epithelial ovarian cancer. Anticancer Res. 2013;33:371-7 pubmed
    b>Fascin-1 (FSCN1) plays an important role in cancer development and is associated with invasion and metastasis. Therefore, we explored the expression and localization of FSCN1 in epithelial ovarian cancer (EOC)...
  3. Ono S, Yamakita Y, Yamashiro S, Matsudaira P, Gnarra J, Obinata T, et al. Identification of an actin binding region and a protein kinase C phosphorylation site on human fascin. J Biol Chem. 1997;272:2527-33 pubmed
    b>Fascin is a 55-58-kDa actin-bundling protein, the actin binding of which is regulated by phosphorylation (Yamakita, Y., Ono, S., Matsumura, F., and Yamashiro, S. (1996) J. Biol. Chem. 271, 12632-12638)...
  4. Pinkus G, Pinkus J, Langhoff E, Matsumura F, Yamashiro S, Mosialos G, et al. Fascin, a sensitive new marker for Reed-Sternberg cells of hodgkin's disease. Evidence for a dendritic or B cell derivation?. Am J Pathol. 1997;150:543-62 pubmed
    Immunohistochemical localization of human fascin, a distinct 55-kd actin-bundling protein, was determined for a wide variety of lymphoid tissues (364 specimens total)...
  5. Zou J, Yang H, Chen F, Zhao H, Lin P, Zhang J, et al. Prognostic significance of fascin-1 and E-cadherin expression in laryngeal squamous cell carcinoma. Eur J Cancer Prev. 2010;19:11-7 pubmed publisher
    b>Fascin-1 and E-cadherin, both of which are related to cell motility and cell adhesiveness, are important factors in the progression and metastasis of cancers...
  6. ARATYN Y, Schaus T, Taylor E, Borisy G. Intrinsic dynamic behavior of fascin in filopodia. Mol Biol Cell. 2007;18:3928-40 pubmed
    Recent studies showed that the actin cross-linking protein, fascin, undergoes rapid cycling between filopodial filaments...
  7. Stewart C, Crook M, Manso L. Fascin expression in low-grade uterine endometrioid adenocarcinoma: correlation with microcystic, elongated and fragmented (MELF)-type alteration at the deep invasive margin. Histopathology. 2011;59:73-80 pubmed publisher
    The actin-binding protein fascin appears to potentiate the migratory capacity of both normal and neoplastic cells...
  8. Xing P, Li J, Jin F, Zhao T, Liu Q, Dong H, et al. Fascin, an actin-bundling protein, promotes breast cancer progression in vitro. Cell Biochem Funct. 2011;29:303-10 pubmed publisher
    b>Fascin, an actin-cross-linking protein, is up-regulated in breast cancer and correlates with a more aggressive disease...
  9. Jayo A, Parsons M, Adams J. A novel Rho-dependent pathway that drives interaction of fascin-1 with p-Lin-11/Isl-1/Mec-3 kinase (LIMK) 1/2 to promote fascin-1/actin binding and filopodia stability. BMC Biol. 2012;10:72 pubmed publisher
    b>Fascin-1 is an actin crosslinking protein that is important for the assembly of cell protrusions in neurons, skeletal and smooth muscle, fibroblasts, and dendritic cells...

More Information

Publications71

  1. Ross R, Ross X, Schwing J, Langin T, Reske Kunz A. The actin-bundling protein fascin is involved in the formation of dendritic processes in maturing epidermal Langerhans cells. J Immunol. 1998;160:3776-82 pubmed
    ..Two cDNA fragments were identified as fragments of fascin, indicating that fascin is differentially expressed in LC...
  2. Pelosi G, Pastorino U, Pasini F, Maissoneuve P, Fraggetta F, Iannucci A, et al. Independent prognostic value of fascin immunoreactivity in stage I nonsmall cell lung cancer. Br J Cancer. 2003;88:537-47 pubmed
    b>Fascin-1, the most expressed form of fascin in vertebrate tissues, is an actin-bundling protein that induces cell membrane protrusions and increases motility of normal and transformed epithelial cells...
  3. Goncharuk V, Ross J, Carlson J. Actin-binding protein fascin expression in skin neoplasia. J Cutan Pathol. 2002;29:430-8 pubmed
    b>Fascin containing actin bundles provide mechanical support to cellular protrusions and stress fibers. In cancers, some malignant cells (e.g. subsets of breast and ovarian carcinomas) express fascin...
  4. Rodriguez Pinilla S, Sarrio D, Honrado E, Hardisson D, Calero F, Benitez J, et al. Prognostic significance of basal-like phenotype and fascin expression in node-negative invasive breast carcinomas. Clin Cancer Res. 2006;12:1533-9 pubmed
    ..Nevertheless, it has been suggested that they respond to chemotherapy better than other types of tumors. Fascin expression has been associated with lung metastasis in breast cancer...
  5. Yoder B, Tso E, Skacel M, Pettay J, Tarr S, Budd T, et al. The expression of fascin, an actin-bundling motility protein, correlates with hormone receptor-negative breast cancer and a more aggressive clinical course. Clin Cancer Res. 2005;11:186-92 pubmed
    ..In the current study, we investigated the expression of fascin, an actin-bundling motility-associated protein, in 210 invasive breast carcinomas with corresponding 5-year ..
  6. Kano M, Seki N, Kikkawa N, Fujimura L, Hoshino I, Akutsu Y, et al. miR-145, miR-133a and miR-133b: Tumor-suppressive miRNAs target FSCN1 in esophageal squamous cell carcinoma. Int J Cancer. 2010;127:2804-14 pubmed publisher
    ..miR-145, miR-133a and miR-133b), which have conserved sequences in the 3'UTR of FSCN1 (actin-binding protein, Fascin homolog 1), inhibited FSCN1 expression...
  7. Vignjevic D, Schoumacher M, Gavert N, Janssen K, Jih G, Lae M, et al. Fascin, a novel target of beta-catenin-TCF signaling, is expressed at the invasive front of human colon cancer. Cancer Res. 2007;67:6844-53 pubmed
    ..We propose that genes involved in cell migration and invasion, such as fascin1, could serve as novel targets for metastasis prevention. ..
  8. Xie J, Xu L, Wu J, Shen Z, Zhao Q, Du Z, et al. Involvement of CYR61 and CTGF in the fascin-mediated proliferation and invasiveness of esophageal squamous cell carcinomas cells. Am J Pathol. 2010;176:939-51 pubmed publisher
    b>Fascin is overexpressed in esophageal squamous cell [corrected] carcinoma (ESCC) and involved in the proliferation and invasiveness of ESCC cells...
  9. Chen L, Yang S, Jakoncic J, Zhang J, Huang X. Migrastatin analogues target fascin to block tumour metastasis. Nature. 2010;464:1062-6 pubmed publisher
    ..Here we show that these migrastatin analogues target the actin-bundling protein fascin to inhibit its activity...
  10. Megiorni F, Indovina P, Mora B, Mazzilli M. Minor expression of fascin-1 gene (FSCN1) in NTera2 cells depleted of CREB-binding protein. Neurosci Lett. 2005;381:169-74 pubmed
    ..Hybridization experiments on 1.2K human cDNA microarrays showed that the FSCN1 gene, encoding for fascin-1 protein, was clearly less expressed in CBP-depleted cells than in controls...
  11. Kefeli M, Yildiz L, Kaya F, Aydin O, Kandemir B. Fascin expression in uterine smooth muscle tumors. Int J Gynecol Pathol. 2009;28:328-33 pubmed publisher
    ..Morphologically, some variants of leiomyoma can be confused with leiomyosarcoma (LMS). In this study, we compared fascin expression in cases of leiomyoma, leiomyoma variants (LVs), uterine smooth muscle tumor of uncertain malignant ..
  12. Minn A, Gupta G, Siegel P, Bos P, Shu W, Giri D, et al. Genes that mediate breast cancer metastasis to lung. Nature. 2005;436:518-24 pubmed
    ..Others contribute to aggressive growth selectively in the lung. Many encode extracellular proteins and are of previously unknown relevance to cancer metastasis. ..
  13. Uyama N, Iimuro Y, Kawada N, Reynaert H, Suzumura K, Hirano T, et al. Fascin, a novel marker of human hepatic stellate cells, may regulate their proliferation, migration, and collagen gene expression through the FAK-PI3K-Akt pathway. Lab Invest. 2012;92:57-71 pubmed publisher
    b>Fascin is a component of actin bundles and may regulate various cellular events. The expression and function of fascin in human hepatic stellate cells (HSCs) has remained largely uncharacterized...
  14. Wu H, Zafar S, Huan Y, Yee H, Chiriboga L, Wang B. Fascin over expression is associated with dysplastic changes in sinonasal inverted papillomas: a study of 47 cases. Head Neck Pathol. 2009;3:212-6 pubmed publisher
    ..Malignant transformation may develop in up to 15% of cases. Fascin (Fascin 1) is an actin cross-link binding protein required for the formation of actin-based cell-surface ..
  15. Soukup V, Babjuk M, Duskova J, Pesl M, Szakáczová M, Zamecnik L, et al. Does the expression of fascin-1 and tumor subclassification help to assess the risk of recurrence and progression in t1 urothelial urinary bladder carcinoma?. Urol Int. 2008;80:413-8 pubmed publisher
    To evaluate the prognostic value of T1 subclassification and fascin-1 expression in T1 human urothelial cell carcinoma of the bladder...
  16. Yamashiro Matsumura S, Matsumura F. Purification and characterization of an F-actin-bundling 55-kilodalton protein from HeLa cells. J Biol Chem. 1985;260:5087-97 pubmed
    ..into bundles as has been reported for other F-actin-bundling proteins such as fimbrin (Mr = 68,000) and fascin (Mr = 58,000)...
  17. Geyeregger R, Zeyda M, Bauer W, Kriehuber E, Saemann M, Zlabinger G, et al. Liver X receptors regulate dendritic cell phenotype and function through blocked induction of the actin-bundling protein fascin. Blood. 2007;109:4288-95 pubmed
    ..LXR activation along with a complete block in LPS- but not CD40L-induced expression of the actin-bundling protein fascin. Notably, overexpression of fascin in LXR agonist-treated DCs restored immunologic synapse formation and restored ..
  18. Hayashi Y, Osanai M, Lee G. Fascin-1 expression correlates with repression of E-cadherin expression in hepatocellular carcinoma cells and augments their invasiveness in combination with matrix metalloproteinases. Cancer Sci. 2011;102:1228-35 pubmed publisher
    Expression of fascin-1, an actin bundling protein, is a poor prognostic factor in hepatocellular carcinoma (HCC). However, its biological role in HCC cells remains unclear...
  19. Mosialos G, Yamashiro S, Baughman R, Matsudaira P, Vara L, Matsumura F, et al. Epstein-Barr virus infection induces expression in B lymphocytes of a novel gene encoding an evolutionarily conserved 55-kilodalton actin-bundling protein. J Virol. 1994;68:7320-8 pubmed
    ..since it shows 40% amino acid sequence identity to the Drosophila singed gene product and 37% identity to fascin, an echinoderm actin-bundling protein...
  20. Onodera M, Zen Y, Harada K, Sato Y, Ikeda H, Itatsu K, et al. Fascin is involved in tumor necrosis factor-alpha-dependent production of MMP9 in cholangiocarcinoma. Lab Invest. 2009;89:1261-74 pubmed publisher
    b>Fascin is an actin-binding protein involved in the cell motility...
  21. Valkov A, Sorbye S, Kilvaer T, Donnem T, Smeland E, Bremnes R, et al. The prognostic impact of TGF-?1, fascin, NF-?B and PKC-? expression in soft tissue sarcomas. PLoS ONE. 2011;6:e17507 pubmed publisher
    Transforming growth factor-? (TGF-?), fascin, nuclear factor-kappa B (NF-?B) p105, protein-kinase C-zeta (PKC-?), partioning-defective protein-6 (Par-6), E-cadherin and vimentin are tumor promoting molecules through mechanisms involved in ..
  22. Hashimoto Y, Loftis D, Adams J. Fascin-1 promoter activity is regulated by CREB and the aryl hydrocarbon receptor in human carcinoma cells. PLoS ONE. 2009;4:e5130 pubmed publisher
    b>Fascin is an actin-bundling protein that is absent from most normal epithelia yet is upregulated in multiple forms of human carcinoma, where its expression correlates clinically with a poor prognosis...
  23. Kim S, Kim D, Kim M, Jung G, Kim K, Jang J, et al. Fascin expression is related to poor survival in gastric cancer. Pathol Int. 2012;62:777-84 pubmed publisher
    b>Fascin is an actin-binding protein that provides mechanical support and cell motility, and involves cancer cell metastasis...
  24. Shonukan O, Bagayogo I, McCrea P, Chao M, Hempstead B. Neurotrophin-induced melanoma cell migration is mediated through the actin-bundling protein fascin. Oncogene. 2003;22:3616-23 pubmed
    ..Here we show that the actin-bundling protein fascin specifically interacts with p75(NTR) in an NGF-dependent manner by co-immunoprecipitation and colocalization in ..
  25. Zhao J, Zhou Y, Zhang Z, Tian F, Ma N, Liu T, et al. Upregulated fascin1 in non-small cell lung cancer promotes the migration and invasiveness, but not proliferation. Cancer Lett. 2010;290:238-47 pubmed publisher
    ..These results suggest that fascin1 plays a significant role in NSCLC metastasis and may be a target of intervening to prevent the metastasis of NSCLC. ..
  26. Takikita M, Hu N, Shou J, Giffen C, Wang Q, Wang C, et al. Fascin and CK4 as biomarkers for esophageal squamous cell carcinoma. Anticancer Res. 2011;31:945-52 pubmed
    Several studies have suggested that fascin, cytokeratin 14 and cytokeratin 4 may have significant roles as biomarkers for the progression and survival of esophageal squamous cell carcinoma (ESCC)...
  27. Mosialos G, Birkenbach M, Ayehunie S, Matsumura F, Pinkus G, Kieff E, et al. Circulating human dendritic cells differentially express high levels of a 55-kd actin-bundling protein. Am J Pathol. 1996;148:593-600 pubmed
    ..study was initiated to examine the differential expression of an evolutionary conserved human 55-kd actin-bundling (p55) protein that is induced in B lymphocytes by Epstein-Barr virus infection...
  28. Anilkumar N, Parsons M, Monk R, Ng T, Adams J. Interaction of fascin and protein kinase Calpha: a novel intersection in cell adhesion and motility. EMBO J. 2003;22:5390-402 pubmed
    ..We report an unexpected direct association between fascin, an actin-bundling component of filopodia, microspikes and lamellipodial ribs, and protein kinase Calpha (PKCalpha)..
  29. Tubb B, Bardien Kruger S, Kashork C, Shaffer L, Ramagli L, Xu J, et al. Characterization of human retinal fascin gene (FSCN2) at 17q25: close physical linkage of fascin and cytoplasmic actin genes. Genomics. 2000;65:146-56 pubmed
    Retinal fascin is a newly identified photoreceptor-specific paralog of the actin-bundling protein fascin. Fascins crosslink f-actin into highly ordered bundles within dynamic cell extensions such as neuronal growth cone filopodia...
  30. Tsai W, Jin J, Chang W, Chan D, Yeh M, Cherng S, et al. Association of cortactin and fascin-1 expression in gastric adenocarcinoma: correlation with clinicopathological parameters. J Histochem Cytochem. 2007;55:955-62 pubmed
    Cortactin and fascin-1 are important factors in tumor progression. We tested the hypothesis that cortactin and fascin-1 expression correlates with clinicopathological parameters of gastric adenocarcinoma...
  31. Hashimoto Y, Kim D, Adams J. The roles of fascins in health and disease. J Pathol. 2011;224:289-300 pubmed publisher
    ..In this review, we discuss the fascin gene family and its evolution, the actin-bundling activity of fascins and the molecular pathways by which it is ..
  32. Xu Y, Yu S, Lu Z, Liu J, Chen J. Fascin promotes the motility and invasiveness of pancreatic cancer cells. World J Gastroenterol. 2011;17:4470-8 pubmed publisher
    To explore the role of actin-bundling protein, fascin during the progression of pancreatic cancer. The plasmid expressing human fascin-1 was stably transfected into the pancreatic cancer cell line MIA PaCa-2...
  33. Li A, Dawson J, Forero Vargas M, Spence H, Yu X, König I, et al. The actin-bundling protein fascin stabilizes actin in invadopodia and potentiates protrusive invasion. Curr Biol. 2010;20:339-45 pubmed publisher
    b>Fascin is an actin-bundling protein involved in filopodia assembly and cancer invasion and metastasis of multiple epithelial cancer types...
  34. Yamamoto H, Kohashi K, Fujita A, Oda Y. Fascin-1 overexpression and miR-133b downregulation in the progression of gastrointestinal stromal tumor. Mod Pathol. 2013;26:563-71 pubmed publisher
    ..Subsequently, quantitative real-time reverse transcription-PCR revealed that fascin-1 mRNA was upregulated in accordance with miR-133b downregulation in high-grade GIST; this result was consistent ..
  35. Yamashiro S, Yamakita Y, Ono S, Matsumura F. Fascin, an actin-bundling protein, induces membrane protrusions and increases cell motility of epithelial cells. Mol Biol Cell. 1998;9:993-1006 pubmed
    b>Fascin is an actin-bundling protein that is found in membrane ruffles, microspikes, and stress fibers...
  36. Hashimoto Y, Skacel M, Lavery I, Mukherjee A, Casey G, Adams J. Prognostic significance of fascin expression in advanced colorectal cancer: an immunohistochemical study of colorectal adenomas and adenocarcinomas. BMC Cancer. 2006;6:241 pubmed
    b>Fascin is an actin bundling protein with roles in the formation of cell protrusions and motility of mesenchymal and neuronal cells...
  37. Duh F, Latif F, Weng Y, Geil L, Modi W, Stackhouse T, et al. cDNA cloning and expression of the human homolog of the sea urchin fascin and Drosophila singed genes which encodes an actin-bundling protein. DNA Cell Biol. 1994;13:821-7 pubmed
    cDNA clones having extensive sequence identity with the sea urchin fascin and the Drosophila singed gene products were isolated from a human teratocarcinoma cDNA library...
  38. Fu H, Wen J, Hu Z, Luo G, Ren H. Knockdown of fascin1 expression suppresses the proliferation and metastasis of gastric cancer cells. Pathology. 2009;41:655-60 pubmed publisher
  39. Al Alwan M, Olabi S, Ghebeh H, Barhoush E, Tulbah A, Al Tweigeri T, et al. Fascin is a key regulator of breast cancer invasion that acts via the modification of metastasis-associated molecules. PLoS ONE. 2011;6:e27339 pubmed publisher
    The actin-bundling protein, fascin, is a member of the cytoskeletal protein family that has restricted expression in specialized normal cells...
  40. Karasavvidou F, Barbanis S, Pappa D, Moutzouris G, Tzortzis V, Melekos M, et al. Fascin determination in urothelial carcinomas of the urinary bladder: a marker of invasiveness. Arch Pathol Lab Med. 2008;132:1912-5 pubmed publisher
    ..Application of new immunohistochemical markers may facilitate the assessment of invasion. Fascin, one of these markers, is an actin-bundling protein involved in tumor cell migration...
  41. Kim S, Choi I, Cheong T, Lee S, Lotan R, Park S, et al. Galectin-3 increases gastric cancer cell motility by up-regulating fascin-1 expression. Gastroenterology. 2010;138:1035-45.e1-2 pubmed publisher
    ..We investigated the effects of galectin-3 on fascin-1, an actin-bundling protein...
  42. Sun J, He H, Xiong Y, Lu S, Shen J, Cheng A, et al. Fascin protein is critical for transforming growth factor ? protein-induced invasion and filopodia formation in spindle-shaped tumor cells. J Biol Chem. 2011;286:38865-75 pubmed publisher
    b>Fascin, an actin-bundling protein overexpressed in all carcinomas, has been associated with poor prognosis, shorter survival, and more metastatic diseases...
  43. Bros M, Ross X, Pautz A, Reske Kunz A, Ross R. The human fascin gene promoter is highly active in mature dendritic cells due to a stage-specific enhancer. J Immunol. 2003;171:1825-34 pubmed
    ..Recently, we successfully used the promoter of the murine actin-bundling protein fascin to transcriptionally target DC by DNA vaccination in mice...
  44. Parsons M, Adams J. Rac regulates the interaction of fascin with protein kinase C in cell migration. J Cell Sci. 2008;121:2805-13 pubmed publisher
    b>Fascin is an actin-bundling protein that is low or absent in normal epithelia; its upregulation correlates with poor prognosis in many human carcinomas...
  45. Taura A, Taura K, Koyama Y, Yamamoto N, Nakagawa T, Ito J, et al. Hair cell stereociliary bundle regeneration by espin gene transduction after aminoglycoside damage and hair cell induction by Notch inhibition. Gene Ther. 2016;23:415-23 pubmed publisher
    ..Increased uptake of FM1-43 uptake provided evidence of stereociliary function. Espin4 transduction had no effect. The results demonstrate that espin1 gene therapy can restore stereocilia on damaged or regenerated HCs. ..
  46. Wu F, Lin Y, Cui P, Li H, Zhang L, Sun Z, et al. Cdc20/p55 mediates the resistance to docetaxel in castration-resistant prostate cancer in a Bim-dependent manner. Cancer Chemother Pharmacol. 2018;81:999-1006 pubmed publisher
    ..Furthermore, additionally targeting Cdc20 might be a promising solution for the treatment of the CRPC with docetaxel resistance. ..
  47. Dor On E, Raviv S, Cohen Y, Adir O, Padmanabhan K, Luxenburg C. T-plastin is essential for basement membrane assembly and epidermal morphogenesis. Sci Signal. 2017;10: pubmed publisher
    ..Inhibition of myosin II motor activity disrupted basement membrane organization. Our results provide insights into the regulation of cortical actomyosin and its importance for basement membrane assembly and skin morphogenesis. ..
  48. Seo M, Kim J, Suk K. Role of the p55-gamma subunit of PI3K in ALK-induced cell migration: RNAi-based selection of cell migration regulators. Cell Adh Migr. 2017;11:205-210 pubmed publisher
    ..Subsequent studies revealed that ALK promoted cell migration through the PI3K-AKT pathway via the p55γ regulatory subunit of PI3K, rather than more commonly used p85 subunit...
  49. McDonald T, Liang H, Sanoja R, Gotter A, Kuduk S, Coleman P, et al. Pharmacological evaluation of orexin receptor antagonists in preclinical animal models of pain. J Neurogenet. 2016;30:32-41 pubmed publisher
    ..distinct, potent and highly selective ORAs (DORA-2, DORA-12 and DORA-22) in the rat spinal nerve ligation (SNL) injury model of neuropathic pain...
  50. Wang D, Xue Y, Yan Y, Lin M, Yang J, Huang J, et al. Reversal of neurochemical alterations in the spinal dorsal horn and dorsal root ganglia by Mas-related gene (Mrg) receptors in a rat model of spinal nerve injury. Neurobiol Dis. 2016;91:274-83 pubmed publisher
    ..selective MrgC receptor agonist bovine adrenal medulla 8-22 (BAM8-22) in a rat model of L5 spinal nerve ligation (SNL). Intrathecal (i.t.) administration of BAM8-22 (0...
  51. Alici O, Kefeli M, Yildiz L, Baris S, Karagoz F, Kandemir B. Fascin and EMMPRIN expression in primary mucinous tumors of ovary: a tissue microarray study. Pathol Res Pract. 2014;210:934-8 pubmed publisher
    The aim of this study was to compare the expressions of fascin and EMMPRIN in primary malignant, borderline and benign mucinous ovarian tumors, and to investigate the relationship of these markers with tumor progression and their ..
  52. Hou J, Guo Z, Xie J, Li E, Xu L. Fascin overexpression is regulated by the transactivation of the promoter but not by its hypomethylation in esophageal squamous cell carcinoma. Mol Med Rep. 2009;2:843-9 pubmed publisher
    b>Fascin 1 (fascin) is known to be overexpressed in esophageal squamous cell carcinoma (ESCC); however, the mechanisms of this overexpression are unclear...
  53. Lin T, Hsieh M, Lai C, Cheng J, Chau Y, Ruan T, et al. Fbxo3-Dependent Fbxl2 Ubiquitination Mediates Neuropathic Allodynia through the TRAF2/TNIK/GluR1 Cascade. J Neurosci. 2015;35:16545-60 pubmed publisher
    ..neural plasticity, was specifically enhanced in ipsilateral dorsal horn neurons after spinal nerve ligation (SNL; left L5 and L6)...
  54. Zhang Y, Tong X. Expression of the actin-binding proteins indicates that cofilin and fascin are related to breast tumour size. J Int Med Res. 2010;38:1042-8 pubmed
    This study was designed to investigate the expression of four actin-binding proteins, alpha-actinin-4, cofilin 1, fascin and elongation factor 1-alpha 2 (eEF1A2), in samples of breast cancer from 112 patients with different stages of ..
  55. Finck B, Johnson R. Tumor necrosis factor (TNF)-alpha induces leptin production through the p55 TNF receptor. Am J Physiol Regul Integr Comp Physiol. 2000;278:R537-43 pubmed
    ..To answer this question, leptin was measured in plasma of wild-type (WT), p55, and p75 TNFR knockout (KO) mice injected intraperitoneally with murine TNF-alpha and in supernatants from cultured ..
  56. Anderson S, Poudel K, Roh Johnson M, Brabletz T, Yu M, Borenstein Auerbach N, et al. MYC-nick promotes cell migration by inducing fascin expression and Cdc42 activation. Proc Natl Acad Sci U S A. 2016;113:E5481-90 pubmed publisher
    ..MYC-nick accelerates migration by activating the Rho GTPase Cdc42 and inducing fascin expression...
  57. Zhang Y, Yang X, Wu H, Zhou W, Liu Z. MicroRNA-145 inhibits migration and invasion via inhibition of fascin 1 protein expression in non-small-cell lung cancer cells. Mol Med Rep. 2015;12:6193-8 pubmed publisher
    ..b>Fascin 1 (FSCN1), an actin bundling protein, has been implicated in NSCLC...
  58. Huang Y, Chen D, Liu B, Shen W, Ruan Y. Conservation and diversification of polycomb repressive complex 2 (PRC2) proteins in the green lineage. Brief Funct Genomics. 2017;16:106-119 pubmed publisher
    ..We found that some PRC2 core components, e.g. E(z), ESC/FIE and MSI/p55, are ancient and have multiplied coincidently with multicellular evolution...
  59. Stewart Hutchinson P, Szasz T, Jaeger E, Onken M, Cooper J, Morley S. Technical Advance: New in vitro method for assaying the migration of primary B cells using an endothelial monolayer as substrate. J Leukoc Biol. 2017;102:941-948 pubmed publisher
    ..Thus, we demonstrate how the use of endothelial monolayers as a substrate will support future interrogation of molecular pathways essential to B cell migration. ..
  60. Wang G, Zhu S, Gu Y, Chen Q, Liu X, Fu H. MicroRNA-145 and MicroRNA-133a Inhibited Proliferation, Migration, and Invasion, While Promoted Apoptosis in Hepatocellular Carcinoma Cells Via Targeting FSCN1. Dig Dis Sci. 2015;60:3044-52 pubmed publisher
    ..Our study suggests that the abnormal upregulation of FSCN1 in HCC is associated with downregulation of miR-145 and miR-133a, and miR-145 and miR-133a inhibit malignant progression of HCC in vitro, possibly via directly targeting FSCN1. ..
  61. Nozumi M, Nakatsu F, Katoh K, Igarashi M. Coordinated Movement of Vesicles and Actin Bundles during Nerve Growth Revealed by Superresolution Microscopy. Cell Rep. 2017;18:2203-2216 pubmed publisher
    ..and dependent on endophilin-3- and dynamin-1 and that occurs proximal to the leading edge simultaneously with fascin-1-dependent F-actin bundling...
  62. Yuan L, Lou W, Sang J. [Expression and significances of FSCN1 and HGF in nasal inverted papilloma]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2012;26:339-42 pubmed
    ..The abnormal expression of FSCN1 and HGF may be closely correlated with NIP and its malignant process. Analysis of FSCN1 and HGF expression in NIP may be useful in predicting malignant transformation. ..