Fas

Summary

Gene Symbol: Fas
Description: Fas cell surface death receptor
Alias: ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6, tumor necrosis factor receptor superfamily member 6, APO-1 cell surface antigen, CD95 antigen, FASLG receptor, Fas (TNF receptor superfamily, member 6), Fas AMA, TNF receptor superfamily member 6, apoptosis antigen 1, apoptosis signaling receptor FAS, apoptosis-mediating surface antigen FAS, mutant tumor necrosis receptor superfamily member 6, tumor necrosis factor receptor superfamily, member 6
Species: human
Products:     Fas

Top Publications

  1. Dalboni M, Cenedeze M, Manfredi S, Cruz Andreoli M, Pavao Dos Santos O, Canziani M, et al. High serum levels of soluble Fas (sFas) in CKD patients: effects of renal clearance, reabsorption and synthesis. Int J Artif Organs. 2008;31:405-10 pubmed
    Increased serum concentrations of soluble Fas (sFas) have been reported in patients with chronic kidney disease (CKD)...
  2. Park J, Lee W, Jung D, Choi J, Park T, Lee E, et al. Polymorphisms in the FAS and FASL genes and survival of early stage non-small cell lung cancer. Clin Cancer Res. 2009;15:1794-800 pubmed publisher
    This study was conducted to investigate the impact of functional polymorphisms in the FAS and FASL genes on the survival of early stage non-small cell lung cancer (NSCLC) patients...
  3. Jones C, Wain E, Chu C, Tosi I, Foster R, McKenzie R, et al. Downregulation of Fas gene expression in Sézary syndrome is associated with promoter hypermethylation. J Invest Dermatol. 2010;130:1116-25 pubmed publisher
    ..In this study, we analyzed Fas expression in CD4+ lymphocytes at the mRNA and protein levels in a large cohort of SS patients as compared with ..
  4. Zhu Q, Wang T, Ren J, Hu K, Liu W, Wu G. FAS-670A/G polymorphism: A biomarker for the metastasis of nasopharyngeal carcinoma in a Chinese population. Clin Chim Acta. 2010;411:179-83 pubmed publisher
    b>FAS-670 A/G single nucleotide polymorphism has been demonstrated to affect the expression of FAS gene by altering the transcriptional activity of FAS gene promoter...
  5. Vallinoto A, Santana B, Dos Santos E, Santo R, Hermes R, Sousa R, et al. FAS-670A/G single nucleotide polymorphism may be associated with human T lymphotropic virus-1 infection and clinical evolution to TSP/HAM. Virus Res. 2012;163:178-82 pubmed publisher
    b>FAS and FASLG genes are closely linked to the apoptosis mechanism of the immune system and several polymorphisms in these genes have been associated with susceptibility to diseases...
  6. Chatterjee K, Dandara C, Gyllensten U, van der Merwe L, Galal U, Hoffman M, et al. A Fas gene polymorphism influences herpes simplex virus type 2 infection in South African women. J Med Virol. 2010;82:2082-6 pubmed publisher
    ..Apoptosis can be regulated and triggered by the interaction between Fas and Fas Ligand (FasL)...
  7. El Agroudy A, El Baz A. Soluble Fas: a useful marker of inflammation and cardiovascular diseases in uremic patients. Clin Exp Nephrol. 2010;14:152-7 pubmed publisher
    ..These results suggest that sFas may be a marker of inflammation in CKD and ESRD patients. ..
  8. Wu W, Wang H, Guo W, Yang K, Zhao Y, Jiang Y, et al. Up-regulation of Fas reverses cisplatin resistance of human small cell lung cancer cells. J Exp Clin Cancer Res. 2010;29:49 pubmed publisher
    b>Fas/FasL system is a major regulator of apoptosis. The mechanisms by which Fas mediates cisplatin resistance remain unclear...
  9. Cao Y, Miao X, Huang M, Deng L, Lin D, Zeng Y, et al. Polymorphisms of death pathway genes FAS and FASL and risk of nasopharyngeal carcinoma. Mol Carcinog. 2010;49:944-50 pubmed publisher
    The FAS receptor/ligand system is a key regulator of apoptotic cell death and corruption of this signaling pathway has been shown to participate in carcinogenesis...

More Information

Publications71

  1. Zucchi F, da Silva I, Ribalta J, de Souza N, Speck N, Girao M, et al. Fas/CD95 promoter polymorphism gene and its relationship with cervical carcinoma. Eur J Gynaecol Oncol. 2009;30:142-4 pubmed
    ..We tested the hypothesis that the A/G polymorphism at -670 of Fas promoter is associated with an increased risk for cervical cancer, using a matched case-control setting...
  2. Schilling T, Schleithoff E, Kairat A, Melino G, Stremmel W, Oren M, et al. Active transcription of the human FAS/CD95/TNFRSF6 gene involves the p53 family. Biochem Biophys Res Commun. 2009;387:399-404 pubmed publisher
    ..In an attempt to understand how the CD95 gene is regulated by the p53 family, we investigated the contributions of a p53-responsive element (RE) within the ..
  3. Arasteh J, Araste J, Sarvestani E, Aflaki E, Amirghofran Z. Fas gene polymorphisms in systemic lupus erythematosus and serum levels of some apoptosis-related molecules. Immunol Invest. 2010;39:27-38 pubmed publisher
    The frequency of the Fas gene polymorphism at positions-1377 G/A and -670 A/G in 249 patients with systemic lupus erythematosus (SLE) and 212 healthy controls were investigated using the allele-specific polymerase chain reaction...
  4. Chen L, Park S, Tumanov A, Hau A, Sawada K, Feig C, et al. CD95 promotes tumour growth. Nature. 2010;465:492-6 pubmed publisher
    b>CD95 (also called Fas and APO-1) is a prototypical death receptor that regulates tissue homeostasis mainly in the immune system through the induction of apoptosis...
  5. Han W, Zhou Y, Zhong R, Wu C, Song R, Zou L, et al. Functional polymorphisms in FAS/FASL system increase the risk of neuroblastoma in Chinese population. PLoS ONE. 2013;8:e71656 pubmed publisher
    The FAS and FASL system plays a substantial role in apoptosis and immune escape of cells...
  6. Esposito D, Sankar A, Morgner N, Robinson C, Rittinger K, Driscoll P. Solution NMR investigation of the CD95/FADD homotypic death domain complex suggests lack of engagement of the CD95 C terminus. Structure. 2010;18:1378-90 pubmed publisher
    We have addressed complex formation between the death domain (DD) of the death receptor CD95 (Fas/APO-1) with the DD of immediate adaptor protein FADD using nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry, and size-..
  7. Geng L, Zhu B, Dai B, Sui C, Xu F, Kan T, et al. A let-7/Fas double-negative feedback loop regulates human colon carcinoma cells sensitivity to Fas-related apoptosis. Biochem Biophys Res Commun. 2011;408:494-9 pubmed publisher
    Interferon-? (IFN-?) is considered essential for the regulation of anti-tumor reactions as it sensitizes Fas-related apoptosis in HT29 cells, but the mechanism is unclear...
  8. Watson C, O Kane H, Maxwell P, Sharaf O, Petak I, Hyland P, et al. Identification of a methylation hotspot in the death receptor Fas/CD95 in bladder cancer. Int J Oncol. 2012;40:645-54 pubmed publisher
    We characterized Fas immunoreactivity, functionality and its role in the response to mitomycin-C (MMC) chemotherapy in vitro in cell lines and in vivo in bladder washings from 23 transitional cell carcinoma of the bladder (TCCB) patients,..
  9. Li W, Xia D, Wang Y, Li Y, Xue Y, Wu X, et al. Relationship between aberrant methylation of FAS promoter and biological behavior of bladder urothelial carcinoma. J Huazhong Univ Sci Technolog Med Sci. 2011;31:794-798 pubmed publisher
    This study examined the promoter methylation of APO-1/CD95 (Fas) gene in bladder urothelial carcinoma and analyzed the relationship between the Fas promoter methylation and the biological behavior of bladder cancer...
  10. Karimi M, Kapoor V, Sharma S, Das S. Genetic polymorphisms in FAS (CD95) and FAS ligand (CD178) promoters and risk of tobacco-related oral carcinoma: gene-gene interactions in high-risk Indians. Cancer Invest. 2013;31:1-6 pubmed publisher
    We assessed the association of functional single nucleotide polymorphisms (SNP) in FAS -1377, -670 and FAS ligand (FASL) -844 promoters in 139 oral cancer patients and 126 normal subjects by PCR-RFLP...
  11. Li Y, Hao Y, Kang S, Zhou R, Wang N, Qi B. Genetic polymorphisms in the Fas and FasL genes are associated with epithelial ovarian cancer risk and clinical outcomes. Gynecol Oncol. 2013;128:584-9 pubmed publisher
    In this study, we evaluated whether functional polymorphisms within the Fas and FasL genes were associated with the risk of developing epithelial ovarian cancer (EOC) and survival of patients with EOC...
  12. Hashemi M, Fazaeli A, Ghavami S, Eskandari Nasab E, Arbabi F, Mashhadi M, et al. Functional polymorphisms of FAS and FASL gene and risk of breast cancer - pilot study of 134 cases. PLoS ONE. 2013;8:e53075 pubmed publisher
    b>Fas/Fas ligand (FasL) system is one of the key apoptotic signaling entities in the extrinsic apoptotic pathway. De-regulation of this pathway, i.e...
  13. L pez Huertas M, Mateos E, S nchez Del Cojo M, G mez Esquer F, D az Gil G, Rodr guez Mora S, et al. The presence of HIV-1 Tat protein second exon delays fas protein-mediated apoptosis in CD4+ T lymphocytes: a potential mechanism for persistent viral production. J Biol Chem. 2013;288:7626-44 pubmed publisher
  14. Zhang Z, Xue H, Gong W, Wang M, Yuan L, Han S, et al. FAS promoter polymorphisms and cancer risk: a meta-analysis based on 34 case-control studies. Carcinogenesis. 2009;30:487-93 pubmed publisher
    b>FAS is a cell surface receptor involved in apoptotic signal transmission and plays important roles in the etiology of cancer...
  15. Lee Y, Bae S, Choi S, Ji J, Song G. Associations between the FAS -670 A/G and -1,377 G/A polymorphisms and susceptibility to autoimmune rheumatic diseases: a meta-analysis. Mol Biol Rep. 2012;39:10671-9 pubmed publisher
    The aim of this study was to explore whether FAS -670 A/G and -1,377 G/A polymorphisms confer susceptibility to autoimmune rheumatic diseases...
  16. Lee Y, Kyung Kim E, Park H, Cho B, Park Y, Kim J, et al. Expression of Fas and Fas ligand in primary cutaneous squamous cell carcinoma in association with grade of tumor differentiation. Int J Dermatol. 2013;52:1092-7 pubmed publisher
    The aim of this study was to evaluate whether Fas (CD95) and Fas ligand (FasL) immunoreactivity in cutaneous squamous cell carcinoma (SCC) are correlated with grade of tumor differentiation...
  17. Tong N, Zhang L, Sheng X, Wang M, Zhang Z, Fang Y, et al. Functional polymorphisms in FAS, FASL and CASP8 genes and risk of childhood acute lymphoblastic leukemia: a case-control study. Leuk Lymphoma. 2012;53:1360-6 pubmed publisher
    Genetic polymorphisms in the promoter regions of FAS, FASL and CASP8 involved in the apoptotic signaling pathway are thought to be associated with susceptibility to cancer...
  18. Tauzin S, Debure L, Moreau J, Legembre P. CD95-mediated cell signaling in cancer: mutations and post-translational modulations. Cell Mol Life Sci. 2012;69:1261-77 pubmed publisher
    ..b>CD95 (also known as Fas), a member of the tumor necrosis factor receptor (TNF-R) superfamily, has been initially cloned ..
  19. Zhang W, Li C, Wang J, He C. Functional polymorphisms in FAS/FASL system contribute to the risk of occurrence but not progression of gastric cardiac adenocarcinoma. Hepatogastroenterology. 2012;59:141-6 pubmed publisher
    Loss of FAS and gain of aberrant FASL expression are common features of malignant transformation...
  20. Kupcinskas J, Wex T, Bornschein J, Selgrad M, Leja M, Juozaityte E, et al. Lack of association between gene polymorphisms of Angiotensin converting enzyme, Nod-like receptor 1, Toll-like receptor 4, FAS/FASL and the presence of Helicobacter pylori-induced premalignant gastric lesions and gastric cancer in Caucasians. BMC Med Genet. 2011;12:112 pubmed publisher
    ..of genes encoding Angiotensin converting enzyme (ACE), Nod-like receptor 1 (NOD1), Toll-like receptor 4 (TLR4) and FAS/FASL...
  21. Wu J, Wood G. Reduction of Fas/CD95 promoter methylation, upregulation of Fas protein, and enhancement of sensitivity to apoptosis in cutaneous T-cell lymphoma. Arch Dermatol. 2011;147:443-9 pubmed publisher
    To explore the relationships among (Fas) promoter methylation, Fas expression, and apoptotic sensitivity in cutaneous T-cell lymphoma (CTCL). Laboratory investigation. Dermatology research unit of a university medical center...
  22. Wang L, Yang J, Kabaleeswaran V, Rice A, Cruz A, Park A, et al. The Fas-FADD death domain complex structure reveals the basis of DISC assembly and disease mutations. Nat Struct Mol Biol. 2010;17:1324-9 pubmed publisher
    The death-inducing signaling complex (DISC) formed by the death receptor Fas, the adaptor protein FADD and caspase-8 mediates the extrinsic apoptotic program...
  23. Zhu J, Qin C, Wang M, Yan F, Ju X, Meng X, et al. Functional polymorphisms in cell death pathway genes and risk of renal cell carcinoma. Mol Carcinog. 2010;49:810-7 pubmed publisher
    The FAS/FAS ligand (FASL) system plays a key role in regulating apoptotic cell death, and corruption of this signaling pathway has been shown to participate in tumorigenesis...
  24. Kim H, Jin X, Kim H, Lee I, Park K, Park M, et al. Fas and FasL polymorphisms are not associated with acute myeloid leukemia risk in Koreans. DNA Cell Biol. 2010;29:619-24 pubmed publisher
    b>Fas and Fas ligand (FasL) polymorphisms in the promoter regions influence transcriptional activities. The interaction of these two genes plays a crucial role in apoptotic cell death regulation...
  25. Li H, Guo H, Sun T, Zhou Y, Lin D, Zhang W, et al. [Association between Fas/Fas L genes promoter polymorphisms and pathogenic risk of cervical cancer]. Zhonghua Zhong Liu Za Zhi. 2009;31:38-41 pubmed
    To investigate the association between apoptosis genes Fas/Fas L promoter polymorphisms and the risk of the development of cervical cancer. Blood samples were collected from 314 cases with primary cervical cancer and 615 healthy controls...
  26. Zhou R, Wang N, Chen Z, Duan Y, Sun D, Li Y. Polymorphisms in promoter region of FAS and FASL gene and risk of cardia gastric adenocarcinoma. J Gastroenterol Hepatol. 2010;25:555-61 pubmed publisher
    The FAS and FASL system play an important role in regulating apoptotic cell death...
  27. Wang J, Gao J, Li Y, Zhao X, Gao W, Peng L, et al. Functional polymorphisms in FAS and FASL contribute to risk of squamous cell carcinoma of the larynx and hypopharynx in a Chinese population. Gene. 2013;524:193-6 pubmed publisher
    Accumulating evidences indicate that the functional FAS-1377G>A, -670A>G and FASL-844T>C polymorphisms affect the risk of several kinds of cancers...
  28. Xiang N, Li X, Wang G, Tao J, Li X. Association of Fas gene polymorphisms with systemic lupus erythematosus: a meta-analysis. Mol Biol Rep. 2013;40:407-15 pubmed publisher
    The Fas gene polymorphisms -670A/G (rs1800682) and -1377G/A (rs2234767) have been shown to be associated with systemic lupus erythematosus (SLE), but findings are not consistent. To clarify this point, a meta-analysis was performed...
  29. Strauss L, Bergmann C, Whiteside T. Human circulating CD4+CD25highFoxp3+ regulatory T cells kill autologous CD8+ but not CD4+ responder cells by Fas-mediated apoptosis. J Immunol. 2009;182:1469-80 pubmed
    ..Treg from all subjects expressed CD95(+), but only Treg from cancer patients expressed CD95L...
  30. Strauss G, Lindquist J, Arhel N, Felder E, Karl S, Haas T, et al. CD95 co-stimulation blocks activation of naive T cells by inhibiting T cell receptor signaling. J Exp Med. 2009;206:1379-93 pubmed publisher
    b>CD95 is a multifunctional receptor that induces cell death or proliferation depending on the signal, cell type, and cellular context. Here, we describe a thus far unknown function of CD95 as a silencer of T cell activation...
  31. Sorice M, Matarrese P, Tinari A, Giammarioli A, Garofalo T, Manganelli V, et al. Raft component GD3 associates with tubulin following CD95/Fas ligation. FASEB J. 2009;23:3298-308 pubmed publisher
    In a previous investigation, we demonstrated that after CD95/Fas triggering, raft-associated GD3 ganglioside, normally localized at the plasma membrane of T cells, can be detected in mitochondria, where they contribute to apoptogenic ..
  32. Hu Y, Xu Y, Wang Y, Ouyang T, Li J, Wang T, et al. [Prognostic role of apoptosis-related gene Fas-1377 and -670 polymorphisms in breast cancer]. Zhonghua Zhong Liu Za Zhi. 2009;31:104-7 pubmed
    To investigate the correlations between Fas-1377 and -670 polymorphisms and survival in Chinese women with breast cancer...
  33. Shao P, Ding Q, Qin C, Wang M, Tang J, Zhu J, et al. Functional polymorphisms in cell death pathway genes FAS and FAS ligand and risk of prostate cancer in a Chinese population. Prostate. 2011;71:1122-30 pubmed publisher
    ..We hypothesized that the FAS -1377G>A, -670A>G, and FASL -844T>C polymorphisms are associated with risk of prostate cancer (PCa)...
  34. Bivona T, Hieronymus H, Parker J, Chang K, Taron M, Rosell R, et al. FAS and NF-?B signalling modulate dependence of lung cancers on mutant EGFR. Nature. 2011;471:523-6 pubmed publisher
    ..Through a pooled RNA interference screen, we show that knockdown of FAS and several components of the NF-?B pathway specifically enhanced cell death induced by the EGFR TKI erlotinib in ..
  35. Zhang M, Lee S, An C, Xu J, Joshi B, Nabi I, et al. Caveolin-1 mediates Fas-BID signaling in hyperoxia-induced apoptosis. Free Radic Biol Med. 2011;50:1252-62 pubmed publisher
    b>Fas-mediated apoptosis is a crucial cellular event. Fas, the Fas-associated death domain, and caspase 8 form the death-inducing signaling complex (DISC). Activated caspase 8 mediates the extrinsic pathways and cleaves cytosolic BID...
  36. Wang M, Wu D, Tan M, Gong W, Xue H, Shen H, et al. FAS and FAS ligand polymorphisms in the promoter regions and risk of gastric cancer in Southern China. Biochem Genet. 2009;47:559-68 pubmed publisher
    The FAS and FAS ligand (FASLG) system plays a key role in regulating apoptotic cell death, and corruption of this signaling pathway has been shown to participate in tumorigenesis...
  37. Tamimi T, Elgouhari H, Alkhouri N, Yerian L, Berk M, Lopez R, et al. An apoptosis panel for nonalcoholic steatohepatitis diagnosis. J Hepatol. 2011;54:1224-9 pubmed publisher
    ..Plasma caspase 3 generated cytokeratin-18 fragments (CK-18), soluble Fas (sFas), and soluble Fas ligand (sFasL) were measured. Histology was assessed by an experienced hepatopathologist...
  38. Schickel R, Park S, Murmann A, Peter M. miR-200c regulates induction of apoptosis through CD95 by targeting FAP-1. Mol Cell. 2010;38:908-15 pubmed publisher
    ..Cells that have undergone an EMT are known to have an increased resistance to apoptosis. CD95/Fas is an apoptosis-inducing receptor expressed on many tissues and tumor cells...
  39. Gangwar R, Mittal R. Association of selected variants in genes involved in cell cycle and apoptosis with bladder cancer risk in North Indian population. DNA Cell Biol. 2010;29:349-56 pubmed publisher
    ..Cell cycle (MDM2 and Cyclin D1) and apoptotic (Fas) genes that are differentially expressed in urinary bladder cancer (UBC) were investigated with the susceptibility ..
  40. Qiu L, Shi J, Yuan H, Jiang X, Xue K, Pan H, et al. FAS -1,377 G/A polymorphism is associated with cancer susceptibility: evidence from 10,564 cases and 12,075 controls. Hum Genet. 2009;125:431-5 pubmed publisher
    Published data on the association between FAS -1,377 G/A polymorphism and cancer risk are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed...
  41. Mandal R, Mittal R. Are cell cycle and apoptosis genes associated with prostate cancer risk in North Indian population?. Urol Oncol. 2012;30:555-61 pubmed publisher
    ..value of 3 different genes associated with CaP carcinogenesis, encoding for cell cycle (MDM2, CCND1) and apoptotic (Fas) genes that are differentially expressed in CaP...
  42. Li Q, Peng J, Li X, Liu T, Liang Q, Zhang G. Clinical significance of Fas and FasL protein expression in gastric carcinoma and local lymph node tissues. World J Gastroenterol. 2010;16:1274-8 pubmed
    To investigate the relation of Fas and Fas ligand (FasL) protein expression with carcinogenesis and metastasis of gastric carcinoma...
  43. Wang L, Ting S, Chen C, Tsai C, Lung O, Liu T, et al. Polymorphisms in the apoptosis-associated genes FAS and FASL and risk of oral cancer and malignant potential of oral premalignant lesions in a Taiwanese population. J Oral Pathol Med. 2010;39:155-61 pubmed publisher
    Our aim was to measure the relationship of FAS (-1377G>A and -670A>G), FASL (-844C>T) gene variants and risk of oral cancer...
  44. Zou C, Ma J, Wang X, Guo L, Zhu Z, Stoops J, et al. Lack of Fas antagonism by Met in human fatty liver disease. Nat Med. 2007;13:1078-85 pubmed
    ..to apoptosis and undergo escalated apoptotic activity via death receptor-mediated pathways, particularly that of Fas-FasL, causing hepatic injury that can eventually proceed to cirrhosis and end-stage liver disease...
  45. Drappa J, Vaishnaw A, Sullivan K, Chu J, Elkon K. Fas gene mutations in the Canale-Smith syndrome, an inherited lymphoproliferative disorder associated with autoimmunity. N Engl J Med. 1996;335:1643-9 pubmed
    ..gld) phenotype led us to investigate whether it too is caused by mutations of the Fas gene (lpr mice) or the Fas ligand (gld mice), which regulate apoptosis in lymphocytes...
  46. Oehm A, Behrmann I, Falk W, Pawlita M, Maier G, Klas C, et al. Purification and molecular cloning of the APO-1 cell surface antigen, a member of the tumor necrosis factor/nerve growth factor receptor superfamily. Sequence identity with the Fas antigen. J Biol Chem. 1992;267:10709-15 pubmed
    ..4 cDNA library. The deduced amino acid sequence of APO-1 showed sequence identity with the Fas antigen, a cysteine-rich transmembrane protein of 335 amino acids with significant similarity to the members of the ..
  47. Feuk L, Prince J, Breen G, Emahazion T, Carothers A, St Clair D, et al. apolipoprotein-E dependent role for the FAS receptor in early onset Alzheimer's disease: finding of a positive association for a polymorphism in the TNFRSF6 gene. Hum Genet. 2000;107:391-6 pubmed
    The TNFRSF6 gene encodes FAS, a cell-surface receptor involved in apoptosis initiation. Elevated levels of FAS have been reported in the brains of Alzheimer's disease (AD) patients...
  48. Lee Y, Kim Y, Ji J, Sohn J, Song G. Fas promoter -670 polymorphism is associated with development of anti-RNP antibodies in systemic lupus erythematosus. J Rheumatol. 2001;28:2008-11 pubmed
    To evaluate whether the polymorphism of Fas promoter -670 is associated with susceptibility to systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) and their clinical features...
  49. Gormus U, Ergen A, Yaylim Eraltan I, Yilmaz H, Turna A, Bozkurt N, et al. Fas-1377 A/G polymorphism in lung cancer. In Vivo. 2007;21:663-6 pubmed
    Reduced expression of Fas and/or increased expression of FasL is known to exist in some cancer types including lung cancer, so the Fas/FasL system may play a role in the course of cancer...
  50. Zhang H, Sun X, Synnerstad I, Rosdahl I. Importance of FAS-1377, FAS-670, and FASL-844 polymorphisms in tumor onset, progression, and pigment phenotypes of Swedish patients with melanoma: a case-control analysis. Cancer J. 2007;13:233-7 pubmed
    ..The FAS gene and its natural ligand (FASL) gene initiate the death signal cascade, playing a central role in the apoptotic ..
  51. Feig C, Tchikov V, Schütze S, Peter M. Palmitoylation of CD95 facilitates formation of SDS-stable receptor aggregates that initiate apoptosis signaling. EMBO J. 2007;26:221-31 pubmed
    Apoptosis signaling through CD95 (Fas/APO-1) involves aggregation and clustering of the receptor followed by its actin-dependent internalization...
  52. Chinnaiyan A, O Rourke K, Tewari M, Dixit V. FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell. 1995;81:505-12 pubmed
    Using the cytoplasmic domain of Fas in the yeast two-hybrid system, we have identified a novel interacting protein, FADD, which binds Fas and Fas-FD5, a mutant of Fas possessing enhanced killing activity, but not the functionally ..
  53. Kase S, Osaki M, Adachi H, Kaibara N, Ito H. Expression of Fas and Fas ligand in esophageal tissue mucosa and carcinomas. Int J Oncol. 2002;20:291-7 pubmed
    The Fas ligand (FasL) and its receptor Fas play a key role in the initiation of an apoptotic pathway...
  54. Lai H, Lin W, Lin Y, Chang C, Yu M, Chen C, et al. Genetic polymorphisms of FAS and FASL (CD95/CD95L) genes in cervical carcinogenesis: An analysis of haplotype and gene-gene interaction. Gynecol Oncol. 2005;99:113-8 pubmed
    ..Resistance to apoptosis is a hallmark of cancer in which FAS/FAS ligand signaling plays an important role...
  55. Choi C, Benveniste E. Fas ligand/Fas system in the brain: regulator of immune and apoptotic responses. Brain Res Brain Res Rev. 2004;44:65-81 pubmed
    ..The external pathway is mainly triggered by ligation of death receptors such as Fas, tumor necrosis factor (TNF)-related apoptosis inducing ligand-R1 (TRAIL-R1), TRAIL-R2 and TNFRp55, and mediated by ..
  56. Raghuraman S, Abraham P, Daniel H, Ramakrishna B, Sridharan G. Characterization of soluble FAS, FAS ligand and tumour necrosis factor-alpha in patients with chronic HCV infection. J Clin Virol. 2005;34:63-70 pubmed
    There are limited reports on the role of the cell surface receptor Fas and its ligand molecule in mediating apoptosis during infection with the hepatitis C virus (HCV)...
  57. Lai H, Sytwu H, Sun C, Yu M, Yu C, Liu H, et al. Single nucleotide polymorphism at Fas promoter is associated with cervical carcinogenesis. Int J Cancer. 2003;103:221-5 pubmed
    ..Apoptosis is an important fail-safe check for tumor development, in which Fas/FasL interaction contributes substantially...
  58. Lopatinskaya L, van Boxel Dezaire A, Barkhof F, Polman C, Lucas C, Nagelkerken L. The development of clinical activity in relapsing-remitting MS is associated with a decrease of FasL mRNA and an increase of Fas mRNA in peripheral blood. J Neuroimmunol. 2003;138:123-31 pubmed
    In this longitudinal study, we examined the expression of Fas, FasL, CCR3, CCR5 and CXCR3 mRNA in peripheral blood mononuclear cells (PBMCs) of secondary progressive (SP) and relapsing-remitting (RR) multiple sclerosis (MS) patients...
  59. Papoff G, Cascino I, Eramo A, Starace G, Lynch D, Ruberti G. An N-terminal domain shared by Fas/Apo-1 (CD95) soluble variants prevents cell death in vitro. J Immunol. 1996;156:4622-30 pubmed
    Fas/Apo-1 molecule, also designated as CD95, is a member of the TNF receptor family. Fas cross-linking by its natural ligand or by agonistic mAbs results in rapid induction of apoptosis in susceptible cells...
  60. Cheng J, Zhou T, Liu C, Shapiro J, Brauer M, Kiefer M, et al. Protection from Fas-mediated apoptosis by a soluble form of the Fas molecule. Science. 1994;263:1759-62 pubmed
    b>Fas is an apoptosis-signaling receptor molecule on the surface of a number of cell types...
  61. Wang L, Cheng L, Spitz M, Wei Q. Fas A670G polymorphism, apoptotic capacity in lymphocyte cultures, and risk of lung cancer. Lung Cancer. 2003;42:1-8 pubmed
    ..We also investigated the frequency of the -A670G polymorphism in Fas, a gene involved in controlling the apoptotic pathway, by using polymerase chain reaction-restriction fragment ..
  62. Kang S, Dong S, Seo S, Kim J, Park S. FAS -1377 G/A polymorphism and the risk of lymph node metastasis in cervical cancer. Cancer Genet Cytogenet. 2008;180:1-5 pubmed
    Single-nucleotide polymorphisms of the FAS -1377G/A, FAS -670A/G, and FASL -844T/C genes may alter transcriptional activity of these genes...