FANCL

Summary

Gene Symbol: FANCL
Description: Fanconi anemia complementation group L
Alias: FAAP43, PHF9, POG, E3 ubiquitin-protein ligase FANCL, PHD finger protein 9, RING-type E3 ubiquitin transferase FANCL, fanconi anemia group L protein, fanconi anemia-associated polypeptide of 43 kDa
Species: human
Products:     FANCL

Top Publications

  1. Zhang J, Wang X, Lin C, Couch F, Fei P. Altered expression of FANCL confers mitomycin C sensitivity in Calu-6 lung cancer cells. Cancer Biol Ther. 2006;5:1632-6 pubmed
    ..six FA proteins, essential for the activation of the FA-BRCA pathway, detected substantially reduced expression of FANCL, a catalytic subunit of the ubiquitin ligase/E3-complex...
  2. Zhi G, Wilson J, Chen X, Krause D, Xiao Y, Jones N, et al. Fanconi anemia complementation group FANCD2 protein serine 331 phosphorylation is important for fanconi anemia pathway function and BRCA2 interaction. Cancer Res. 2009;69:8775-83 pubmed publisher
    ..with at least 13 complementation groups (FANCA, FANCB, FANCC, FANCD1, FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ, FANCL, FANCM, and FANCN)...
  3. Gurtan A, Stuckert P, D Andrea A. The WD40 repeats of FANCL are required for Fanconi anemia core complex assembly. J Biol Chem. 2006;281:10896-905 pubmed
    ..b>FANCL, which possesses three WD40 repeats and a plant homeodomain (PHD), is the putative E3 ubiquitin ligase subunit of ..
  4. Ling C, Ishiai M, Ali A, Medhurst A, Neveling K, Kalb R, et al. FAAP100 is essential for activation of the Fanconi anemia-associated DNA damage response pathway. EMBO J. 2007;26:2104-14 pubmed
    ..The complex consists of eight FA proteins, including a ubiquitin ligase (FANCL) and a DNA translocase (FANCM), and is essential for monoubiquitination of FANCD2 in response to DNA damage...
  5. Kim J, Kee Y, Gurtan A, D Andrea A. Cell cycle-dependent chromatin loading of the Fanconi anemia core complex by FANCM/FAAP24. Blood. 2008;111:5215-22 pubmed publisher
    ..Dysregulated loading of the FA core complex accounts, at least in part, for the characteristic cellular and developmental abnormalities in FA. ..
  6. Yan Z, Delannoy M, Ling C, Daee D, Osman F, Muniandy P, et al. A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability. Mol Cell. 2010;37:865-78 pubmed publisher
    ..Thus, FANCM-MHF is an essential DNA-remodeling complex that protects replication forks from yeast to human. ..
  7. Singh T, Saro D, Ali A, Zheng X, Du C, Killen M, et al. MHF1-MHF2, a histone-fold-containing protein complex, participates in the Fanconi anemia pathway via FANCM. Mol Cell. 2010;37:879-86 pubmed publisher
    ..These findings reveal critical roles of the MHF1-MHF2 dimer in DNA damage repair and genome maintenance through FANCM. ..
  8. Meetei A, Medhurst A, Ling C, Xue Y, Singh T, Bier P, et al. A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M. Nat Genet. 2005;37:958-63 pubmed
    ..2,3). We previously purified a Fanconi anemia core complex containing the FANCL ubiquitin ligase and six other Fanconi anemia-associated proteins...
  9. Zhang J, Zhao D, Park H, Wang H, Dyer R, Liu W, et al. FAVL elevation in human tumors disrupts Fanconi anemia pathway signaling and promotes genomic instability and tumor growth. J Clin Invest. 2010;120:1524-34 pubmed publisher
    ..we report that elevated expression of what we believe to be a novel splice variant of FA complementation group L (FANCL), which we identified and named FAVL, can impair the FA pathway in non-FA human tumor cells and act as a tumor ..

More Information

Publications118 found, 100 shown here

  1. Geng L, Huntoon C, Karnitz L. RAD18-mediated ubiquitination of PCNA activates the Fanconi anemia DNA repair network. J Cell Biol. 2010;191:249-57 pubmed publisher
    ..monoubiquitylation of the FA complementation group I (FANCI)-FANCD2 (ID) complex by FA complementation group L (FANCL), an E3 ubiquitin ligase...
  2. Hodson C, Cole A, Lewis L, Miles J, Purkiss A, Walden H. Structural analysis of human FANCL, the E3 ligase in the Fanconi anemia pathway. J Biol Chem. 2011;286:32628-37 pubmed publisher
    ..of the FANCI-FANCD2 (ID) complex by the multiprotein "core complex" containing the E3 ubiquitin ligase FANCL. Vertebrate organisms have the eight-protein core complex, whereas invertebrates apparently do not...
  3. Dao K, Rotelli M, Petersen C, Kaech S, Nelson W, Yates J, et al. FANCL ubiquitinates ?-catenin and enhances its nuclear function. Blood. 2012;120:323-34 pubmed publisher
    ..through the formation of a multisubunit nuclear complex that facilitates the E3 ubiquitin ligase activity of FANCL. However, it is not known whether loss of E3 ubiquitin ligase activity accounts for the hematopoietic stem cell ..
  4. Meetei A, de Winter J, Medhurst A, Wallisch M, Waisfisz Q, van de Vrugt H, et al. A novel ubiquitin ligase is deficient in Fanconi anemia. Nat Genet. 2003;35:165-70 pubmed
    ..is defective in a cell line derived from an individual with Fanconi anemia, we conclude that PHF9 (also called FANCL) represents a novel Fanconi anemia complementation group (FA-L)...
  5. Alpi A, Langevin F, Mosedale G, Machida Y, Dutta A, Patel K. UBE2T, the Fanconi anemia core complex, and FANCD2 are recruited independently to chromatin: a basis for the regulation of FANCD2 monoubiquitination. Mol Cell Biol. 2007;27:8421-30 pubmed
    ..FANCD2 monoubiquitination is therefore not regulated by multiprotein complex assembly but by the formation of an active E2/E3 holoenzyme on chromatin. ..
  6. Alpi A, Pace P, Babu M, Patel K. Mechanistic insight into site-restricted monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCI. Mol Cell. 2008;32:767-77 pubmed publisher
    ..Here, we minimally reconstitute this monoubiquitination reaction with Ube2t and the FANCL protein, revealing that monoubiquitination is stimulated by a conserved RWD-like domain in FANCL...
  7. Longerich S, Kwon Y, Tsai M, Hlaing A, Kupfer G, Sung P. Regulation of FANCD2 and FANCI monoubiquitination by their interaction and by DNA. Nucleic Acids Res. 2014;42:5657-70 pubmed publisher
    ..Using the ubiquitin conjugating enzyme (E2) UBE2T and ubiquitin ligase (E3) FANCL, monoubiquitination of human FANCD2 and FANCI was examined...
  8. Medhurst A, Laghmani E, Steltenpool J, Ferrer M, Fontaine C, de Groot J, et al. Evidence for subcomplexes in the Fanconi anemia pathway. Blood. 2006;108:2072-80 pubmed
    ..Two new FA genes, FANCB and FANCL, have recently been identified, and their discovery has allowed a more detailed study into the molecular ..
  9. Machida Y, Machida Y, Chen Y, Gurtan A, Kupfer G, D Andrea A, et al. UBE2T is the E2 in the Fanconi anemia pathway and undergoes negative autoregulation. Mol Cell. 2006;23:589-96 pubmed
    ..Here, we show that UBE2T is the ubiquitin-conjugating enzyme (E2) essential for this pathway. UBE2T binds to FANCL, the ubiquitin ligase subunit of the Fanconi anemia core complex, and is required for the monoubiquitination of ..
  10. Ciccia A, Ling C, Coulthard R, Yan Z, Xue Y, Meetei A, et al. Identification of FAAP24, a Fanconi anemia core complex protein that interacts with FANCM. Mol Cell. 2007;25:331-43 pubmed
    ..Our data indicate that the FANCM/FAAP24 complex may play a key role in recruitment of the FA core complex to damaged DNA. ..
  11. Longerich S, San Filippo J, Liu D, Sung P. FANCI binds branched DNA and is monoubiquitinated by UBE2T-FANCL. J Biol Chem. 2009;284:23182-6 pubmed publisher
    ..We also demonstrate that FANCI can be ubiquitinated on Lys-523 by the UBE2T-FANCL pair in vitro...
  12. Sato K, Toda K, Ishiai M, Takata M, Kurumizaka H. DNA robustly stimulates FANCD2 monoubiquitylation in the complex with FANCI. Nucleic Acids Res. 2012;40:4553-61 pubmed publisher
    ..FANCD2 is monoubiquitylated by the FA core complex, composed of 10 FA proteins including FANCL as the catalytic E3 subunit...
  13. Ali A, Pradhan A, Singh T, Du C, Li J, Wahengbam K, et al. FAAP20: a novel ubiquitin-binding FA nuclear core-complex protein required for functional integrity of the FA-BRCA DNA repair pathway. Blood. 2012;119:3285-94 pubmed publisher
    ..These findings reveal critical roles for FAAP20 in the FA-BRCA pathway of DNA damage repair and genome maintenance. ..
  14. Yan Z, Guo R, Paramasivam M, Shen W, Ling C, Fox D, et al. A ubiquitin-binding protein, FAAP20, links RNF8-mediated ubiquitination to the Fanconi anemia DNA repair network. Mol Cell. 2012;47:61-75 pubmed publisher
    ..Thus, the RNF8-FAAP20 ubiquitin cascade is critical for recruiting FA core complex to ICLs and for normal function of the FA network. ..
  15. Huang Y, Leung J, Lowery M, Matsushita N, Wang Y, Shen X, et al. Modularized functions of the Fanconi anemia core complex. Cell Rep. 2014;7:1849-57 pubmed publisher
    ..Of the seven FA gene products forming the core complex, FANCL possesses a RING domain with demonstrated E3 ligase activity...
  16. Xu L, Cai J, Tian A, Qian K, Qin R, Qi S, et al. The Effect of Prim-O-Glucosylcimifugin on Tryptase-Induced Intestinal Barrier Dysfunction in Caco-2 Cells. Biol Pharm Bull. 2018;41:1355-1361 pubmed publisher
    ..The objective of this study was to evaluate the effect of Prim-O-glucosylcimifugin (POG) on intestinal barrier dysfunction and reveal possible molecular mechanisms...
  17. Abadi A, Alyass A, Robiou du Pont S, Bolker B, Singh P, Mohan V, et al. Penetrance of Polygenic Obesity Susceptibility Loci across the Body Mass Index Distribution. Am J Hum Genet. 2017;101:925-938 pubmed publisher
    ..60 × 10-6), rs11873305 (MC4R; p = 5.08 × 10-5), rs12617233 (FANCL; p = 5.30 × 10-5), rs11672660 (GIPR; p = 1.64 × 10-4), rs997295 (MAP2K5; p = 3...
  18. Yamashita A, Iwaki L, Pinto G, Gerke B, Chicarelli M, Iwaki Filho L. Accuracy of two-dimensional pharyngeal airway space prediction for bimaxillary orthognathic surgery. Oral Maxillofac Surg. 2018;22:197-202 pubmed publisher
    ..size of the PAS was calculated at the level of four craniometric points: A, occlusal plane (Mx), B, and pogonion (Pog). Two previously calibrated examiners performed these measurements...
  19. Margol A, Yeo K, Xia C, Onar A, Robison N, Freyer D, et al. A comparative analysis of clinicopathological features and survival among early adolescents/young adults and children with low-grade glioma: a report from the Children's Oncology Group. J Neurooncol. 2018;140:575-582 pubmed publisher
    ..This was a secondary analysis of Children's Oncology Group legacy study CCG-9891/POG-9130, which enrolled participants 0-21 years of age with newly-diagnosed LGG treated with surgery alone...
  20. Gül Amuk N, Topsakal K, Baser Keklikci H. Effects of Different Head Positioning Methods on Facial Soft Tissue Analysis Using Stereophotogrammetry. J Oral Maxillofac Surg. 2019;: pubmed publisher
    ..Pn), soft tissue A point (A'), upper lip (Ls), lower lip (Li), soft tissue B point (B)', and soft tissue pogonion (Pog') to the true vertical line (TVL) and face height and lip length measurements...
  21. Fernandez C, Smith C, Yang W, Mullighan C, Qu C, Larsen E, et al. Genome-wide analysis links NFATC2 with asparaginase hypersensitivity. Blood. 2015;126:69-75 pubmed publisher
    ..Total XIIIA (n = 154), Total XV (n = 498), and Total XVI (n = 271), or Children's Oncology Group protocols POG 9906 (n = 222) and AALL0232 (n = 2163). Germline DNA was genotyped using the Affymetrix 500K, Affymetrix 6...
  22. Hemmatpour S, Mokhtar A, Rakhshan V. Effects of Sabbagh Universal Spring 2 fixed functional appliance on class II/1 patients at their postpubertal-peak growth period compared with the extraction method : A randomized clinical trial. J Orofac Orthop. 2017;78:41-51 pubmed publisher
    ..in the following variables: ANB, nasolabial angle, Mand1-ML, 1L-NB, anterior and posterior facial heights, N-A-Pog, 1U-NF, 6L-MP, Ar-Go, OP-HP, A-B, A-Sn, B-Sm, APDI, NAPog, AB-NPog, POr-DOP, SN-OcP, POr-OcP, Wits, 1 l-APog, ..
  23. Zhang B, Jung M, Tu Y, Gollub R, Lang C, Ortiz A, et al. Identifying brain regions associated with the neuropathology of chronic low back pain: a resting-state amplitude of low-frequency fluctuation study. Br J Anaesth. 2019;: pubmed publisher
    ..ALFF was increased in the post-/precentral gyrus (PoG/PrG), paracentral lobule (PCL)/supplementary motor area (SMA), and anterior cingulate cortex (ACC), and grey matter ..
  24. Lebuis A, Bortoluzzi P, Huynh N, Bach N. Occlusal Relations in Patients With Scaphocephaly. J Craniofac Surg. 2015;26:1893-9 pubmed publisher
    ..enough, cephalometric values indicative of skeletal class II malocclusions (ie, N-A perp HP, N-B perp HP, N-Pog perp HP, Wits, N-A-Pog) remained within normal limits...
  25. Takahashi Y, Higashihori N, Yasuda Y, Takada J, Moriyama K. Examination of craniofacial morphology in Japanese patients with congenitally missing teeth: a cross-sectional study. Prog Orthod. 2018;19:38 pubmed publisher
    ..the oligodontia group had significantly smaller U1 to FH plane angle, L1 to mandibular plane angle, Ptm-A, and Go-Pog; it also had significantly larger U1-L1...
  26. Zhang N, Wang S, Fan L, Chen X, Li X. [Changes of soft tissues in patients with functional and skeletal Angel Class Ⅲ malocclusion after FRⅢ appliance therapy]. Shanghai Kou Qiang Yi Xue. 2017;26:658-661 pubmed
    ..After treatment, FCA,NLA, Pog labial angle,upper lip to E line were increased significantly (P<0.05)...
  27. Rodriguez Mari A, Canestro C, Bremiller R, Nguyen Johnson A, Asakawa K, Kawakami K, et al. Sex reversal in zebrafish fancl mutants is caused by Tp53-mediated germ cell apoptosis. PLoS Genet. 2010;6:e1001034 pubmed publisher
    ..We identified a mutation in the zebrafish fancl gene that causes homozygous mutants to develop as fertile males due to female-to-male sex reversal...
  28. Zhao Z, Yost S, Hutchinson K, Li S, Yuan Y, Noorbakhsh J, et al. CCNE1 amplification is associated with poor prognosis in patients with triple negative breast cancer. BMC Cancer. 2019;19:96 pubmed publisher
    ..A panel of eight cancer driver genes (CCNE1, TPX2, ELF3, FANCL, JAK2, GSK3B, CEP76, and SYK) were differentially expressed in recurrent TNBCs, and were also overexpressed in ..
  29. Unal T, Celikoglu M, Candirli C. Evaluation of the effects of skeletal anchoraged Forsus FRD using miniplates inserted on mandibular symphysis: A new approach for the treatment of Class II malocclusion. Angle Orthod. 2015;85:413-9 pubmed publisher
    ..001). The overjet correction (-5.11 mm) was found to be mainly by skeletal changes (A-VRL, -1.16 mm and Pog-VRL, 2.62 mm; approximately 74%); the remaining changes were due to the dentoalveolar contributions...
  30. Mishra S, Bagga R, Kalra J, Jain V, Dutta S. Routine second trimester cervical length screening in low risk women identified women at risk of a 'very' preterm birth but did not reduce the preterm birth rate: a randomised study from India. J Obstet Gynaecol. 2018;38:789-795 pubmed publisher
    ..at 'low risk' for a preterm birth (PTB), a singleton pregnancy and for a 16-24 week period of gestation (POG) were randomised to undergo cervical length (CL) measurement by transvaginal sonography (TVS) or not...
  31. Paulino A, Mahajan A, Ye R, Grosshans D, Fatih Okcu M, Su J, et al. Ototoxicity and cochlear sparing in children with medulloblastoma: Proton vs. photon radiotherapy. Radiother Oncol. 2018;128:128-132 pubmed publisher
    ..3%) and 9 of 91 (9.9%) ears (Brock, p = 0.91), 13 of 75 (17.3%) and 19 of 91 (20.9%) ears (POG, p = 0.56), and 15 of 75 (20.0%) and 21 of 91 (23.1%) ears (SIOP Boston, p = 0...
  32. Isaacsson Velho P, Qazi F, Hassan S, Carducci M, Denmeade S, Markowski M, et al. Efficacy of Radium-223 in Bone-metastatic Castration-resistant Prostate Cancer with and Without Homologous Repair Gene Defects. Eur Urol. 2018;: pubmed publisher
    ..7%) had a germline/somatic HRD mutation (three in BRCA2, and one each in ATM, ATR, CHEK2, FANCG, FANCI, FANCL, and PALB2) and 18 (64.3%) did not. Men with HRD mutations (HRD+) had numerically lower ages (66 vs 73yr, p=0...
  33. Bonache S, Esteban I, Moles Fernández A, Tenés A, Duran Lozano L, Montalban G, et al. Multigene panel testing beyond BRCA1/2 in breast/ovarian cancer Spanish families and clinical actionability of findings. J Cancer Res Clin Oncol. 2018;144:2495-2513 pubmed publisher
    ..variants were detected in candidate BC/OC genes in 17 patients (1 BARD1, 1 ERCC3, 1 ERCC5, 2 FANCE, 1 FANCI, 2 FANCL, 1 FANCM, 1 MCPH1, 1 PPM1D, 2 RBBP8, 3 RECQL4 and 1 with SLX4 and XRCC2), three of which also carry pathogenic ..
  34. Qu X, Li H, Braziel R, Passerini V, Rimsza L, Hsi E, et al. Genomic alterations important for the prognosis in patients with follicular lymphoma treated on SWOG study S0016. Blood. 2018;: pubmed publisher
    ..29, 5.03)] and 2p cnLOH [P=0.005, OR=10.9 (2.08, 57.2)], 2p gain specifically encompassing VRK2 and FANCL predicted PFS [P=0.01, HR=1.80 (1.14, 2.68)] as well as OS [P=0.005, 2.40 (1.30, 4...
  35. Song L. A possible approach for stem cell gene therapy of Fanconi anemia. Curr Gene Ther. 2009;9:26-32 pubmed
    ..and 13 distinct genes have been cloned (FANCA, FANCB, FANCC, FANCD1, FANCD2, FANCE, FANCF, FANCG, FNACI, FANCJ, FANCL, FANCM, FANCN)...
  36. Celikoglu M, Buyuk S, Ekizer A, Unal T. Pharyngeal airway effects of Herbst and skeletal anchored Forsus FRD EZ appliances. Int J Pediatr Otorhinolaryngol. 2016;90:23-28 pubmed publisher
    ..groups, skeletal Class II malocclusion was corrected by decrease in SNA and increase in SNB, Co-Gn, VRL-B and VRL-Pog measurements. Those changes caused a significant correction in the maxillo-mandibular relationship...
  37. Ford K, Nguyen A, Hegedus E, Taylor J. Vertical Jump Biomechanics Altered With Virtual Overhead Goal. J Appl Biomech. 2017;33:153-159 pubmed publisher
    ..The purpose was to compare jump performance and biomechanics with a physical overhead goal (POG) and with a virtual overhead goal (VOG). Fourteen female subjects participated (age: 18.8 ± 1.1 years, height: 163...
  38. Chen C, Chern S, Wu P, Chen S, Lai S, Chuang T, et al. Prenatal diagnosis of a 3.2-Mb 2p16.1-p15 duplication associated with familial intellectual disability. Taiwan J Obstet Gynecol. 2018;57:578-582 pubmed publisher
    ..0 [GRCh37 (hg19)] encompassing eight Online Mendelian Inheritance in Man (OMIM) genes of VRK2, FANCL, BCL11A, PAPOLG, REL, PUS10, PEX13 and USP34 in the fetus and the two women...
  39. Fostira F, Saloustros E, Apostolou P, Vagena A, Kalfakakou D, Mauri D, et al. Germline deleterious mutations in genes other than BRCA2 are infrequent in male breast cancer. Breast Cancer Res Treat. 2018;169:105-113 pubmed publisher
    ..7% of the cases, distributed in six genes: BRCA2, ATM, BRCA1, CHEK2, PMS2, and FANCL. BRCA2 mutations were the most frequent, followed by ATM mutations, accounting for 6...
  40. Shokri A, Khajeh S, Khavid A. Evaluation of the accuracy of linear measurements on lateral cephalograms obtained from cone-beam computed tomography scans with digital lateral cephalometric radiography: an in vitro study. J Craniofac Surg. 2014;25:1710-3 pubmed publisher
    ..anterior nasal spine-nasion (ANS-N), anterior nasal spine-posterior nasal spine (ANS-PNS), and pogonion-gonion (Pog-Go). Then, images were obtained by using DLCs and in lateral cephalograms obtained from CBCT scans...
  41. Walter R, Walter D, Boswell W, Caballero K, Boswell M, Lu Y, et al. Exposure to fluorescent light triggers down regulation of genes involved with mitotic progression in Xiphophorus skin. Comp Biochem Physiol C Toxicol Pharmacol. 2015;178:93-103 pubmed publisher
    ..g., atm2, brip1, fanc1, fancl, and xrcc4)...
  42. Beumer J, Fu K, Anyang B, Siegfried J, Bakkenist C. Functional analyses of ATM, ATR and Fanconi anemia proteins in lung carcinoma : ATM, ATR and FA in lung carcinoma. BMC Cancer. 2015;15:649 pubmed publisher
    ..We included Calu6 that is reported to be FANCL-deficient...
  43. Wang F, Gao C, Lu J, Tatetsu H, Williams D, Müller L, et al. Leukemic survival factor SALL4 contributes to defective DNA damage repair. Oncogene. 2016;35:6087-6095 pubmed publisher
    ..Characterization of the leukemic initiation population in this model leads to the discovery that Fancl (Fanconi anemia, complementation group L) is downregulated in SALL4B Tg leukemic and pre-leukemic cells...
  44. Alwarawrah M, Hussain F, Huang J. Alteration of lipid membrane structure and dynamics by diacylglycerols with unsaturated chains. Biochim Biophys Acta. 2016;1858:253-63 pubmed publisher
    ..In this study, three DAGs of distinctly different chain unsaturations (i.e. di16:0DAG (DPG), 16:0-18:1DAG (POG), and di18:1DAG (DOG)) are studied using atomistic MD simulation to compare their roles in the structure and ..
  45. Jiang J, Bellani M, Li L, Wang P, Seidman M, Wang Y. Arsenite Binds to the RING Finger Domain of FANCL E3 Ubiquitin Ligase and Inhibits DNA Interstrand Crosslink Repair. ACS Chem Biol. 2017;12:1858-1866 pubmed publisher
    ..with elevated sensitivity toward DNA interstrand cross-linking agents, and monoubiquitination of FANCD2 by FANCL is a crucial step in FA-mediated DNA repair...
  46. Marshall C, Fu W, Wang H, Baras A, Lotan T, Antonarakis E. Prevalence of DNA repair gene mutations in localized prostate cancer according to clinical and pathologic features: association of Gleason score and tumor stage. Prostate Cancer Prostatic Dis. 2019;22:59-65 pubmed publisher
    ..Homologous recombination repair genes included in our analysis were: ATM, BRCA1/2, CDK12, CHEK1/2, FANCA, FANCD2, FANCL, GEN1, NBN, PALB2, RAD51, and RAD51C...
  47. Chen C, Chen M, Cheng J, Chen K, Tseng Y. Facial profile and frontal changes after bimaxillary surgery in patients with mandibular prognathism. J Formos Med Assoc. 2018;117:632-639 pubmed publisher
    ..incision superius (Is), labrale inferius (Li), incision inferius (Ii), point B, labiomental sulcus (Si), pogonion (Pog), soft tissue pogonion (PogS), ramus point (RP), and gonion (Go)...
  48. Mustafa M, Garg N, Banerjee B, Sharma T, Tyagi V, Dar S, et al. Inflammatory-mediated pathway in association with organochlorine pesticides levels in the etiology of idiopathic preterm birth. Reprod Toxicol. 2015;57:111-20 pubmed publisher
    ..Elevated levels of β-HCH along with high expression of COX-2 gene or low expression of Mn-SOD or CAT genes were associated with the decrease in the period of gestation (POG).
  49. Słowiński J, Czarnecka A. Numerical modeling of the traction process in the treatment for Pierre-Robin Sequence. Int J Pediatr Otorhinolaryngol. 2016;89:86-91 pubmed publisher
    ..The adopted growth measure was mandibular length increase, defined as the distance between the Co-Pog anatomic points used in cephalometric analysis...
  50. El Hayeck E, Bassil Nassif N, Mouhanna Fattal C, Bouserhal J. Skeletal and dento-alveolar norms: Conventional and based on true vertical in a Lebanese population. Int Orthod. 2017;15:180-198 pubmed publisher
    ..Differences between males and females were found especially at the B and Pog points, which were more posterior in men, who also presented a greater lower facial height in relation to total ..
  51. Chen P, Li J, Chen Y, Qian H, Chen Y, Su J, et al. The functional status of DNA repair pathways determines the sensitization effect to cisplatin in non-small cell lung cancer cells. Cell Oncol (Dordr). 2016;39:511-522 pubmed
    ..siRNA-mediated silencing of the FA-associated genes FANCL and RAD18 and the HR-associated genes BRCA1 and BRCA2 significantly potentiated the sensitivity of A549/DR cells ..
  52. Lisboa C, Martins M, Ruellas A, Ferreira D, Maia L, Mattos C. Soft tissue assessment before and after mandibular advancement or setback surgery using three-dimensional images: systematic review and meta-analysis. Int J Oral Maxillofac Surg. 2018;47:1389-1397 pubmed publisher
    ..868) and moderate for the lower lip/lower incisor (r=0.690). The ratio for lower lip/infradentale was 78% and for Pog'/Pog was 98%...
  53. Panneerselvam J, Park H, Zhang J, Dudimah F, Zhang P, Wang H, et al. FAVL impairment of the Fanconi anemia pathway promotes the development of human bladder cancer. Cell Cycle. 2012;11:2947-55 pubmed publisher
    ..In this study, we found FAVL (variant of FA protein L--FANCL) was elevated substantially in bladder cancer tissues examined...
  54. Hamodat H, Cash M, Fisk J, Darvesh S. Cholinesterases in normal and Alzheimer's disease primary olfactory gyrus. Neuropathol Appl Neurobiol. 2017;43:571-583 pubmed publisher
    ..The primary olfactory gyrus (POG) is comprised of the olfactory tract, anterior olfactory nucleus (AON) and olfactory area (OA)...
  55. Tseng Y, Chen H, Cheng J, Chen P, Pan C, Chou S, et al. Appearance on face reading (cheek line) after orthognathic surgery. Br J Oral Maxillofac Surg. 2018;56:394-400 pubmed publisher
    ..At the time of the final follow-up (T2-T1), the mean (SD) horizontal setback of pogonion (Pog) was 12.3 (3.5) mm for women and 11.7 (4.3) mm for men...
  56. Lu B, Bishop C. Mouse GGN1 and GGN3, two germ cell-specific proteins from the single gene Ggn, interact with mouse POG and play a role in spermatogenesis. J Biol Chem. 2003;278:16289-96 pubmed
    ..We have recently shown that the gene underlying this mutation is Pog, which is necessary for normal proliferation of PGCs...
  57. Meetei A, Sechi S, Wallisch M, Yang D, Young M, Joenje H, et al. A multiprotein nuclear complex connects Fanconi anemia and Bloom syndrome. Mol Cell Biol. 2003;23:3417-26 pubmed
    ..The findings that FA proteins are part of a DNA-unwinding complex imply that FA proteins may participate in DNA repair. ..
  58. Asselin B, Devidas M, Chen L, Franco V, Pullen J, Borowitz M, et al. Cardioprotection and Safety of Dexrazoxane in Patients Treated for Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia or Advanced-Stage Lymphoblastic Non-Hodgkin Lymphoma: A Report of the Children's Oncology Group Randomized Trial Pediatric Oncology. J Clin Oncol. 2016;34:854-62 pubmed publisher
    ..Patients were treated on Pediatric Oncology Group Protocol POG 9404, which included random assignment to treatment with or without dexrazoxane given as a bolus infusion ..
  59. Tyagi V, Mustafa M, Sharma T, Banerjee B, Ahmed R, Tripathi A, et al. Association of organochlorine pesticides with the mRNA expression of tumour necrosis factor-alpha (TNF-?) & cyclooxygenase-2 (COX-2) genes in idiopathic preterm birth. Indian J Med Res. 2016;143:731-738 pubmed publisher
    ..l0 inear positive correlations were observed between period of gestation (POG) and ?Ct of COX-2 and TNF-? genes...
  60. Gao W, Zheng Q, Shen Z, Wu H, Ma Y, Guan W, et al. A facile one-step folic acid modified partially oxidized graphene for high sensitivity tumor cell sensing. Analyst. 2016;141:4713-8 pubmed publisher
    A highly sensitive and selective tumor cell sensor based on partially oxidized graphene (POG) and folate acid (FA) composite was constructed...
  61. Rickman K, Lach F, Abhyankar A, Donovan F, Sanborn E, Kennedy J, et al. Deficiency of UBE2T, the E2 Ubiquitin Ligase Necessary for FANCD2 and FANCI Ubiquitination, Causes FA-T Subtype of Fanconi Anemia. Cell Rep. 2015;12:35-41 pubmed publisher
    ..UBE2T is known to interact with FANCL, the E3 ubiquitin-ligase component of the multiprotein FA core complex, and is necessary for the ..
  62. He X, Duan J, Zhou J, Song Z, Cichello S. Effects of Two Traditional Chinese Cooking Oils, Canola and Pork, on pH and Cholic Acid Content of Faeces and Colon Tumorigenesis in Kunming Mice. Asian Pac J Cancer Prev. 2015;16:6225-9 pubmed
    ..randomized into various groups; negative control group (NCG), azoxymethane control group (ACG), pork oil group (POG), and canola oil Ggroup (COG)...
  63. Lhota F, Zemánková P, Kleiblova P, Soukupova J, Vocka M, Stránecký V, et al. Hereditary truncating mutations of DNA repair and other genes in BRCA1/BRCA2/PALB2-negatively tested breast cancer patients. Clin Genet. 2016;90:324-33 pubmed publisher
    ..The most frequent variant in FA genes was c.1096_1099dupATTA in FANCL that also show a borderline association with increased BC risk in subsequent analysis of enlarged groups of BC ..
  64. Chandrasekharappa S, Chinn S, Donovan F, Chowdhury N, Kamat A, Adeyemo A, et al. Assessing the spectrum of germline variation in Fanconi anemia genes among patients with head and neck carcinoma before age 50. Cancer. 2017;123:3943-3954 pubmed publisher
    ..load, of FA gene variants was observed in carriers of the genes FA complementation group D2 (FANCD2), FANCE, and FANCL in the HNSCC patient cohort relative to the 1000 Genomes population...
  65. Kao W, Riker A, Kushwaha D, Ng K, Enkemann S, Jove R, et al. Upregulation of Fanconi anemia DNA repair genes in melanoma compared with non-melanoma skin cancer. J Invest Dermatol. 2011;131:2139-42 pubmed publisher
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    ..09 mm for the right side. For mandibular position changes, measurement points that moved more than 2 mm were Pog, Me, and Mental foramen in both groups...
  67. Wendl B, Muchitsch A, Winsauer H, Walter A, Droschl H, Jakse N, et al. Retrospective 25-year follow-up of treatment outcomes in angle Class III patients : Early versus late treatment. J Orofac Orthop. 2017;78:201-210 pubmed publisher
    ..in addition, a greater skeletal discrepancy between maxilla and mandible, higher values for mandibular length, Cond-Pog, ramus height, overjet, anterior posterior dysplasia indicator (APDI), lower anterior face height, and gonial angle..
  68. Chow White P, Ha D, Laskin J. Knowledge, attitudes, and values among physicians working with clinical genomics: a survey of medical oncologists. Hum Resour Health. 2017;15:42 pubmed publisher
    ..5% response rate), who are actively involved in a clinical genomics trial called Personalized Onco-Genomics (POG)...
  69. Majanni A, Hajeer M. The Removable Mandibular Retractor vs the Bone-anchored Intermaxillary Traction in the Correction of skeletal class III Malocclusion in children: A Randomized Controlled Trial. J Contemp Dent Pract. 2016;17:361-71 pubmed
    ..69 mm) than in the RMR group (x = 1.05 mm; p < 0.001). Points B and Pog showed posterior movement in the BAIMT group (x=-3.01 and -2...
  70. Dao K, Rotelli M, Brown B, Yates J, Rantala J, Tognon C, et al. The PI3K/Akt1 pathway enhances steady-state levels of FANCL. Mol Biol Cell. 2013;24:2582-92 pubmed publisher
    ..Here we provide evidence that FANCL, the E3 ubiquitin ligase of the Fanconi anemia pathway, is constitutively targeted for degradation by the ..
  71. Xue Y, Li Y, Guo R, Ling C, Wang W. FANCM of the Fanconi anemia core complex is required for both monoubiquitination and DNA repair. Hum Mol Genet. 2008;17:1641-52 pubmed publisher
    ..These data are consistent with participation of FANCM and its associated FA core complex in the FA pathway at both signaling through monoubiquitination and the ensuing DNA repair. ..
  72. Huang M, Kennedy R, Ali A, Moreau L, Meetei A, D Andrea A, et al. Human MutS and FANCM complexes function as redundant DNA damage sensors in the Fanconi Anemia pathway. DNA Repair (Amst). 2011;10:1203-12 pubmed publisher
    ..Further, MSH2 was co-purified and co-immunoprecipitated with FA core complex components. Taken together, our results suggest that human MutS homologs and FANCM complexes function as redundant DNA damage sensors of the FA pathway. ..
  73. Li Y, Rodewald L, Hoppmann C, Wong E, Lebreton S, Safar P, et al. A versatile platform to analyze low-affinity and transient protein-protein interactions in living cells in real time. Cell Rep. 2014;9:1946-58 pubmed publisher
  74. Pradhan A, Ustiyan V, Zhang Y, Kalin T, Kalinichenko V. Forkhead transcription factor FoxF1 interacts with Fanconi anemia protein complexes to promote DNA damage response. Oncotarget. 2016;7:1912-26 pubmed publisher
    ..These findings demonstrate that FoxF1 is a key component of FA complexes and a critical mediator of DNA damage response in tumor cells. ..
  75. Sumpter R, Sirasanagandla S, Fernández A, Wei Y, Dong X, Franco L, et al. Fanconi Anemia Proteins Function in Mitophagy and Immunity. Cell. 2016;165:867-81 pubmed publisher
    ..Moreover, additional genes in the FA pathway, including FANCA, FANCF, FANCL, FANCD2, BRCA1, and BRCA2, are required for mitophagy...
  76. Ganguly B, Kadam N. Mutations of myelodysplastic syndromes (MDS): An update. Mutat Res Rev Mutat Res. 2016;769:47-62 pubmed publisher
    ..KRAS, NRAS, CBL, NF1, PTPN11); cohesin complex (STAG2, CTCF, SMC1A, RAD21); DNA repair (ATM, BRCC3, DLRE1C, FANCL); and other pathway genes have given insights into the independent effects and interaction of co-occurrence of ..
  77. Nian L, Hu Y, Fu C, Song C, Wang J, Xiao J. Fluorescence self-quenching assay for the detection of target collagen sequences using a short probe peptide. Talanta. 2018;176:492-498 pubmed publisher
    ..targeting ability of probe peptides is length-dependent, and have discovered a relatively short probe peptide FAM-G(POG)8 capable to identify the target peptide...
  78. Agoulnik A, Lu B, Zhu Q, Truong C, Ty M, Arango N, et al. A novel gene, Pog, is necessary for primordial germ cell proliferation in the mouse and underlies the germ cell deficient mutation, gcd. Hum Mol Genet. 2002;11:3047-53 pubmed
    ..PGC proliferation rather than aberrant migration and is caused by the partial deletion of a single novel gene, Pog (proliferation of germ cells). Pog is critical for normal PGC proliferation, starting between 9.5 and 10...
  79. Hess C, Ameziane N, Schuurhuis G, Errami A, Denkers F, Kaspers G, et al. Hypermethylation of the FANCC and FANCL promoter regions in sporadic acute leukaemia. Cell Oncol. 2008;30:299-306 pubmed
    ..MS-MLPA showed promoter methylation of FANCC in one AML and three ALL samples, while FANCL was found methylated in one ALL sample...
  80. Vetro A, Iascone M, Limongelli I, Ameziane N, Gana S, Della Mina E, et al. Loss-of-Function FANCL Mutations Associate with Severe Fanconi Anemia Overlapping the VACTERL Association. Hum Mutat. 2015;36:562-8 pubmed publisher
    ..on the analysis of the exome in one family and of a panel of Fanconi genes in the second one, we identified novel FANCL truncating mutations in both families...
  81. Swuec P, Renault L, Borg A, Shah F, Murphy V, van Twest S, et al. The FA Core Complex Contains a Homo-dimeric Catalytic Module for the Symmetric Mono-ubiquitination of FANCI-FANCD2. Cell Rep. 2017;18:611-623 pubmed publisher
    ..DNA interstrand crosslink repair pathway in higher eukaryotes requires mono-ubiquitination of FANCI and FANCD2 by FANCL, the E3 ligase subunit of the Fanconi anemia core complex...
  82. Fu W, Tang J, Wang H, Wei H, Cai S, Zeng Z, et al. In vivo and in vitro anti-sepsis effects of physcion 8-O-β-glucopyranoside extracted from Rumex japonicus. Chin J Nat Med. 2017;15:534-539 pubmed publisher
    The present study was designed to investigate the anti-sepsis effects of physcion 8-O-β-glucopyranoside (POG) isolated from Rumex japonicas and explore its possible pharmacological mechanisms. POG was extracted from R...
  83. Takata K, Tomida J, Reh S, Swanhart L, Takata M, Hukriede N, et al. Conserved overlapping gene arrangement, restricted expression, and biochemical activities of DNA polymerase ν (POLN). J Biol Chem. 2015;290:24278-93 pubmed publisher
    ..Although the physiological function of pol ν remains to be clarified, this study uncovers distinctive aspects of its expression control and evolutionarily conserved properties of this DNA polymerase. ..
  84. Walker K, Nan R, Wright D, Gor J, Bishop A, Makhatadze G, et al. Non-linearity of the collagen triple helix in solution and implications for collagen function. Biochem J. 2017;474:2203-2217 pubmed publisher
    ..of collagen triple helical peptides, composed of six, eight, ten and twelve repeats of the most stable Pro-Hyp-Gly (POG) units...
  85. Tremblay C, Huang F, Habi O, Huard C, Godin C, Levesque G, et al. HES1 is a novel interactor of the Fanconi anemia core complex. Blood. 2008;112:2062-70 pubmed publisher
    ..HES1 is also required for proper nuclear localization or stability of some members of the core complex. Our results suggest that HES1 is a novel interacting protein of the FA core complex. ..
  86. Juko Pecirep I, Ivansson E, Gyllensten U. Evaluation of Fanconi anaemia genes FANCA, FANCC and FANCL in cervical cancer susceptibility. Gynecol Oncol. 2011;122:377-81 pubmed publisher
    ..TagSNPs in FANCA, FANCC and FANCL were selected using the Tagger algorithm in Haploview...
  87. Hodson C, Purkiss A, Miles J, Walden H. Structure of the human FANCL RING-Ube2T complex reveals determinants of cognate E3-E2 selection. Structure. 2014;22:337-44 pubmed publisher
    ..Using the Fanconi Anemia pathway exclusive E3-E2 pair, FANCL-Ube2T, we report the atomic structure of the FANCL RING-Ube2T complex, revealing a specific and extensive network ..
  88. Jang S, Jung J, Kim J. Replication Protein A (RPA) deficiency activates the Fanconi anemia DNA repair pathway. Cell Cycle. 2016;15:2336-45 pubmed publisher
    ..Taken together, these results indicate that RPA deficiency induces activation of the FA pathway in an ATR-dependent manner, which may play a role in the genome maintenance. ..
  89. Wu W, Liu Y, Zhou Q, Wang Q, Luo F, Xu Z, et al. Novel homozygous FANCL mutation and somatic heterozygous SETBP1 mutation in a Chinese girl with Fanconi Anemia. Eur J Med Genet. 2017;60:369-373 pubmed publisher
    ..FA complementation group L (FA-L, OMIM #608111) occurred in 0.2% of all FA and only eight mutant variants in the FANCL gene were documented. Phenotype and genotype correlation in FANCL associated FA is still obscure...
  90. Meetei A, Levitus M, Xue Y, Medhurst A, Zwaan M, Ling C, et al. X-linked inheritance of Fanconi anemia complementation group B. Nat Genet. 2004;36:1219-24 pubmed
    ..Its presence as a single active copy and essentiality for a functional Fanconi anemia-BRCA pathway make FANCB a potentially vulnerable component of the cellular machinery that maintains genomic integrity. ..