FANCC

Summary

Gene Symbol: FANCC
Description: Fanconi anemia complementation group C
Alias: FA3, FAC, FACC, Fanconi anemia group C protein
Species: human
Products:     FANCC

Top Publications

  1. Youssoufian H. Localization of Fanconi anemia C protein to the cytoplasm of mammalian cells. Proc Natl Acad Sci U S A. 1994;91:7975-9 pubmed
    ..The function of the recently isolated FACC (Fanconi anemia group C complementing) gene for a subset of this disorder is not yet known...
  2. Strathdee C, Gavish H, Shannon W, Buchwald M. Cloning of cDNAs for Fanconi's anaemia by functional complementation. Nature. 1992;356:763-7 pubmed
    ..The cDNAs encode alternatively processed transcripts of a new gene, designated FACC, which is mutated in group C patients...
  3. Gibson R, Buchwald M, Roberts R, Mathew C. Characterisation of the exon structure of the Fanconi anaemia group C gene by vectorette PCR. Hum Mol Genet. 1993;2:35-8 pubmed
    A cDNA for Fanconi anaemia complementation group C (FACC) has recently been cloned. We have now isolated a yeast artificial chromosome clone containing the FACC gene, and used vectorette PCR to determine its exon structure...
  4. Gavish H, dos Santos C, Buchwald M. A Leu554-to-Pro substitution completely abolishes the functional complementing activity of the Fanconi anemia (FACC) protein. Hum Mol Genet. 1993;2:123-6 pubmed
    ..site directed in vitro mutagenesis, we demonstrate that this mutation completely abolishes the activity of the FACC protein as analyzed by functional complementation assay...
  5. Hoatlin M, Christianson T, Keeble W, Hammond A, Zhi Y, Heinrich M, et al. The Fanconi anemia group C gene product is located in both the nucleus and cytoplasm of human cells. Blood. 1998;91:1418-25 pubmed
    The Fanconi anemia (FA) complementation group C (FAC) protein gene encodes a cytoplasmic protein with a predicted Mr of 63,000...
  6. Cumming R, Lightfoot J, Beard K, Youssoufian H, O Brien P, Buchwald M. Fanconi anemia group C protein prevents apoptosis in hematopoietic cells through redox regulation of GSTP1. Nat Med. 2001;7:814-20 pubmed
    The Fanconi anemia group C protein (FANCC) plays an important role in hematopoiesis by ensuring the survival of hematopoietic progenitor cells through an unknown mechanism...
  7. Gordon S, Buchwald M. Fanconi anemia protein complex: mapping protein interactions in the yeast 2- and 3-hybrid systems. Blood. 2003;102:136-41 pubmed
    ..Eight FA complementation groups have been identified. The FANCA, FANCC, FANCE, FANCF, and FANCG proteins form a nuclear complex required for the monoubiquination of the FANCD2 protein...
  8. Taniguchi T, Tischkowitz M, Ameziane N, Hodgson S, Mathew C, Joenje H, et al. Disruption of the Fanconi anemia-BRCA pathway in cisplatin-sensitive ovarian tumors. Nat Med. 2003;9:568-74 pubmed
    ..sensitivity and is governed by the coordinate activity of six genes associated with Fanconi anemia (FANCA, FANCC, FANCD2, FANCE, FANCF and FANCG) as well as BRCA1 and BRCA2 (FANCD1)...
  9. Brodeur I, Goulet I, Tremblay C, Charbonneau C, Delisle M, Godin C, et al. Regulation of the Fanconi anemia group C protein through proteolytic modification. J Biol Chem. 2004;279:4713-20 pubmed
    The function of the Fanconi anemia group C protein (FANCC) is still unknown, though many studies point to a role in damage response signaling...

More Information

Publications111 found, 100 shown here

  1. Niedzwiedz W, Mosedale G, Johnson M, Ong C, Pace P, Patel K. The Fanconi anaemia gene FANCC promotes homologous recombination and error-prone DNA repair. Mol Cell. 2004;15:607-20 pubmed
    The Fanconi anemia (FA) protein FANCC is essential for chromosome stability in vertebrate cells, a feature underscored by the extreme sensitivity of FANCC-deficient cells to agents that crosslink DNA...
  2. Couch F, Johnson M, Rabe K, Boardman L, McWilliams R, de Andrade M, et al. Germ line Fanconi anemia complementation group C mutations and pancreatic cancer. Cancer Res. 2005;65:383-6 pubmed
    ..The recent identification of FANCC and FANCG mutations in resected pancreatic tumors selected for loss of heterozygosity on chromosome 9, some of ..
  3. Meetei A, Medhurst A, Ling C, Xue Y, Singh T, Bier P, et al. A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M. Nat Genet. 2005;37:958-63 pubmed
    ..Our data suggest an evolutionary link between Fanconi anemia-associated proteins and DNA repair; FANCM may act as an engine that translocates the Fanconi anemia core complex along DNA. ..
  4. Ciccia A, Ling C, Coulthard R, Yan Z, Xue Y, Meetei A, et al. Identification of FAAP24, a Fanconi anemia core complex protein that interacts with FANCM. Mol Cell. 2007;25:331-43 pubmed
    ..Our data indicate that the FANCM/FAAP24 complex may play a key role in recruitment of the FA core complex to damaged DNA. ..
  5. Tremblay C, Huang F, Habi O, Huard C, Godin C, Levesque G, et al. HES1 is a novel interactor of the Fanconi anemia core complex. Blood. 2008;112:2062-70 pubmed publisher
    ..HES1 is also required for proper nuclear localization or stability of some members of the core complex. Our results suggest that HES1 is a novel interacting protein of the FA core complex. ..
  6. Hess C, Ameziane N, Schuurhuis G, Errami A, Denkers F, Kaspers G, et al. Hypermethylation of the FANCC and FANCL promoter regions in sporadic acute leukaemia. Cell Oncol. 2008;30:299-306 pubmed
    ..MS-MLPA showed promoter methylation of FANCC in one AML and three ALL samples, while FANCL was found methylated in one ALL sample...
  7. Sinha S, Singh R, Alam N, Roy A, Roychoudhury S, Panda C. Alterations in candidate genes PHF2, FANCC, PTCH1 and XPA at chromosomal 9q22.3 region: pathological significance in early- and late-onset breast carcinoma. Mol Cancer. 2008;7:84 pubmed publisher
    ..Present work focuses on comparative analysis of alterations of four candidate genes; PHF2, FANCC, PTCH1 and XPA located within 4...
  8. Huard C, Tremblay C, Helsper K, Delisle M, Schindler D, Levesque G, et al. Fanconi anemia proteins interact with CtBP1 and modulate the expression of the Wnt antagonist Dickkopf-1. Blood. 2013;121:1729-39 pubmed publisher
    ..Of the fifteen FA proteins, Fanconi anemia group C (FANCC) is one of eight FA core complex components of the FA pathway...
  9. Song L. A possible approach for stem cell gene therapy of Fanconi anemia. Curr Gene Ther. 2009;9:26-32 pubmed
    ..13 complementation groups are currently discovered, and 13 distinct genes have been cloned (FANCA, FANCB, FANCC, FANCD1, FANCD2, FANCE, FANCF, FANCG, FNACI, FANCJ, FANCL, FANCM, FANCN)...
  10. Zhang T, Wilson A, Mahmood Ali A, Namekawa S, Andreassen P, Ruhikanta Meetei A, et al. Loss of Faap20 Causes Hematopoietic Stem and Progenitor Cell Depletion in Mice Under Genotoxic Stress. Stem Cells. 2015;33:2320-30 pubmed publisher
    ..in lethally irradiated recipient mice, with milder phenotype as compared to HSPCs from Fanca(-) (/) (-) or Fancc(-) (/) (-) mice. Faap20(-) (/) (-) mice are susceptible to mitomycin C (MMC)-induced pancytopenia...
  11. Nie Y, Li Y, Li X, Wilson A, Pang Q. The non-homologous end-joining activity is required for Fanconi anemia fetal HSC maintenance. Stem Cell Res Ther. 2019;10:114 pubmed publisher
    ..of NHEJ activity by the knockin DNA-PKcs3A/3A mutation in two FA mouse models, Fanca-/- and Fancc-/-, leads to embryonic lethality...
  12. Li N, Ding L, Li B, Wang J, D Andrea A, Chen J. Functional analysis of Fanconi anemia mutations in China. Exp Hematol. 2018;66:32-41.e8 pubmed publisher
    ..Three missense variants (FANCA-L424V, FANCC-E273K, and FANCG-A153G) were harmless...
  13. Lombardi A, Hoskins E, Foglesong G, Wikenheiser Brokamp K, Wiesmüller L, Hanenberg H, et al. Acquisition of Relative Interstrand Crosslinker Resistance and PARP Inhibitor Sensitivity in Fanconi Anemia Head and Neck Cancers. Clin Cancer Res. 2015;21:1962-72 pubmed publisher
    ..the tumors of patients with Fanconi anemia, and murine HNSCC cell lines derived from the tumors of wild-type and Fancc(-/-) mice, we sought to define Fanconi anemia-dependent chemosensitivity and DNA repair characteristics...
  14. Esteban Jurado C, Franch Expósito S, Muñoz J, Ocaña T, Carballal S, Lopez Ceron M, et al. The Fanconi anemia DNA damage repair pathway in the spotlight for germline predisposition to colorectal cancer. Eur J Hum Genet. 2016;24:1501-5 pubmed publisher
    ..as 6 families carried heterozygous, rare, potentially pathogenic variants located in BRCA2/FANCD1, BRIP1/FANCJ, FANCC, FANCE and REV3L/POLZ...
  15. Epanchintsev A, Shyamsunder P, Verma R, Lyakhovich A. IL-6, IL-8, MMP-2, MMP-9 are overexpressed in Fanconi anemia cells through a NF-κB/TNF-α dependent mechanism. Mol Carcinog. 2015;54:1686-99 pubmed publisher
    ..of additional secretory factors such as IL-6, IL-8, MMP-2, and MMP-9 in FA cells and in cells depleted of FANCA or FANCC and proved that their expression is under the control of NF-κB/TNF-α signaling pathways...
  16. Draga M, Madgett E, Vandenberg C, du Plessis D, Kaufmann A, Werler P, et al. BRCA1 Is Required for Maintenance of Phospho-Chk1 and G2/M Arrest during DNA Cross-Link Repair in DT40 Cells. Mol Cell Biol. 2015;35:3829-40 pubmed publisher
    ..Here, we show that FA-defective (Fancc(-)) DT40 cells arrest in G2 phase following cross-link damage and trigger apoptosis...
  17. Sumpter R, Sirasanagandla S, Fernández A, Wei Y, Dong X, Franco L, et al. Fanconi Anemia Proteins Function in Mitophagy and Immunity. Cell. 2016;165:867-81 pubmed publisher
    ..Here, we describe an essential role for FA genes in two forms of selective autophagy. Genetic deletion of Fancc blocks the autophagic clearance of viruses (virophagy) and increases susceptibility to lethal viral encephalitis...
  18. Cerabona D, Sun Z, Nalepa G. Leukemia and chromosomal instability in aged Fancc-/- mice. Exp Hematol. 2016;44:352-7 pubmed publisher
    ..Here we describe that aging Fancc(-/-) mice are prone to genomically unstable AML and other hematologic neoplasms...
  19. Alavattam K, Kato Y, Sin H, Maezawa S, Kowalski I, Zhang F, et al. Elucidation of the Fanconi Anemia Protein Network in Meiosis and Its Function in the Regulation of Histone Modifications. Cell Rep. 2016;17:1141-1157 pubmed publisher
    ..We reveal a network of FA and DDR proteins in which FA core factors FANCA, FANCB, and FANCC are essential for FANCD2 foci formation, whereas BRCA1 (FANCS), MDC1, and RNF8 are required for BRCA2 (FANCD1) ..
  20. Zhou Y, He Y, Xing W, Zhang P, Shi H, Chen S, et al. An abnormal bone marrow microenvironment contributes to hematopoietic dysfunction in Fanconi anemia. Haematologica. 2017;102:1017-1027 pubmed publisher
    ..Here we demonstrated that mice with double knockout of both Fancc and Fancg genes had decreased bone formation at least partially due to impaired osteoblast ..
  21. Mori M, Hira A, Yoshida K, Muramatsu H, Okuno Y, Shiraishi Y, et al. Pathogenic mutations identified by a multimodality approach in 117 Japanese Fanconi anemia patients. Haematologica. 2019;: pubmed publisher
    ..i>FANCB was the third most common complementation group and only one FANCC case was identified in our series. Based on the data from Tohoku Medical Megabank, we estimate that ~2...
  22. Zhi G, Wilson J, Chen X, Krause D, Xiao Y, Jones N, et al. Fanconi anemia complementation group FANCD2 protein serine 331 phosphorylation is important for fanconi anemia pathway function and BRCA2 interaction. Cancer Res. 2009;69:8775-83 pubmed publisher
    ..bone marrow failure and cancer susceptibility syndrome with at least 13 complementation groups (FANCA, FANCB, FANCC, FANCD1, FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ, FANCL, FANCM, and FANCN)...
  23. Flynn E, Kamat A, Lach F, Donovan F, Kimble D, Narisu N, et al. Comprehensive analysis of pathogenic deletion variants in Fanconi anemia genes. Hum Mutat. 2014;35:1342-53 pubmed publisher
    ..We found pathogenic deletions in 88 FANCA, seven FANCC, two FANCD2, and one FANCB families...
  24. Du W, Amarachintha S, Wilson A, Pang Q. Hyper-active non-homologous end joining selects for synthetic lethality resistant and pathological Fanconi anemia hematopoietic stem and progenitor cells. Sci Rep. 2016;6:22167 pubmed publisher
    ..Disruption of the FA core complex skews PARP1 function in DSB repair and led to hyper-active NHEJ in Fanca(-/-) or Fancc(-/-) HSPCs...
  25. Velimezi G, Robinson Garcia L, Muñoz Martínez F, Wiegant W, Ferreira da Silva J, Owusu M, et al. Map of synthetic rescue interactions for the Fanconi anemia DNA repair pathway identifies USP48. Nat Commun. 2018;9:2280 pubmed publisher
    ..genome-wide loss-of-function screens across a panel of human haploid isogenic FA-defective cells (FANCA, FANCC, FANCG, FANCI, FANCD2)...
  26. Pace P, Johnson M, Tan W, Mosedale G, Sng C, Hoatlin M, et al. FANCE: the link between Fanconi anaemia complex assembly and activity. EMBO J. 2002;21:3414-23 pubmed
    ..Here we show that the recently identified FANCE protein is part of this nuclear complex, binding both FANCC and FANCD2...
  27. Hartmann L, Neveling K, Borkens S, Schneider H, Freund M, Grassman E, et al. Correct mRNA processing at a mutant TT splice donor in FANCC ameliorates the clinical phenotype in patients and is enhanced by delivery of suppressor U1 snRNAs. Am J Hum Genet. 2010;87:480-93 pubmed publisher
    ..The c.165+1G>T germline mutation in the 5'ss of exon 2 of the Fanconi anemia C (FANCC) gene commonly predicted to prevent correct splicing was identified in nine FA patients from three pedigrees...
  28. Kim J, Park B, Pasaje C, Bae J, Park J, Park S, et al. Association of FANCC polymorphisms with FEV1 decline in aspirin exacerbated respiratory disease. Mol Biol Rep. 2012;39:2385-94 pubmed publisher
    ..The exacerbated inflammatory response in Fancc-deficient mice has been reported to be associated with hemopoietic responses that are also related to AERD ..
  29. Garbati M, Hays L, Keeble W, Yates J, Rathbun R, Bagby G. FANCA and FANCC modulate TLR and p38 MAPK-dependent expression of IL-1? in macrophages. Blood. 2013;122:3197-205 pubmed publisher
    Hematopoietic stem and progenitor cells with inactivated Fanconi anemia (FA) genes, FANCA and FANCC, are hypersensitive to inflammatory cytokines...
  30. Levy P, Dioneda B, Holland M, Sekarski T, Lee C, Mathur A, et al. Right ventricular function in preterm and term neonates: reference values for right ventricle areas and fractional area of change. J Am Soc Echocardiogr. 2015;28:559-69 pubmed publisher
    Right ventricular (RV) fractional area of change (FAC) is a quantitative two-dimensional echocardiographic measurement of RV function...
  31. Elboudwarej E, Cole M, Briggs F, Fouts A, Fain P, Quach H, et al. Hypomethylation within gene promoter regions and type 1 diabetes in discordant monozygotic twins. J Autoimmun. 2016;68:23-9 pubmed publisher
    ..2%-5.0%). In the epigenome CpG set, the greatest methylation differences were observed in MAGI2, FANCC, and PCDHB16, (DNAm difference range: 6.9%-16.1%). These findings were not observed in the HLA-identical NTS pairs...
  32. Pandian S, Arya K, Kumar D. Minimal clinically important difference of the lower-extremity fugl-meyer assessment in chronic-stroke. Top Stroke Rehabil. 2016;23:233-9 pubmed publisher
    ..FMA-LE, Functional ambulation classification (FAC), and global rating of patient-perceived changes (GRPPC)...
  33. Taniguchi T, D Andrea A. The Fanconi anemia protein, FANCE, promotes the nuclear accumulation of FANCC. Blood. 2002;100:2457-62 pubmed
    ..The 6 known Fanconi anemia gene products (FANCA, FANCC, FANCD2, FANCE, FANCF, and FANCG proteins) interact in a common pathway...
  34. Gómez Iglesias P, Guyon F, Khatyr A, Ulrich G, Knorr M, Martín Alvarez J, et al. Luminescent rhenium(I) tricarbonyl complexes with pyrazolylamidino ligands: photophysical, electrochemical, and computational studies. Dalton Trans. 2015;44:17516-28 pubmed publisher
    New pyrazolylamidino complexes fac-[ReCl(CO)3(NH[double bond, length as m-dash]C(Me)pz*-κ(2)N,N)] (pz*H = pyrazole, pzH; 3,5-dimethylpyrazole, dmpzH; indazole, indzH) and fac-[ReBr(CO)3(NH[double bond, length as m-dash]C(Ph)pz*-κ(2)..
  35. Li J, Wang L, Sun K, Zhang J. Computational insights into the photophysical and electroluminescence properties of homoleptic fac-Ir(C^N)3 complexes employing different phenyl-derivative-featuring phenylimidazole-based ligands for promising phosphors in OLEDs. Dalton Trans. 2016;45:3034-47 pubmed publisher
    ..However, the addition of the substituent on the para-position of the phenyl ring in the phenylimidazole ligand would increase the quantum yield and electroluminescence (EL) performance compared with that on the imidazole ring. ..
  36. Ahrens T, Ahrens M, Braun T, Braun B, Herrmann R. Synthesis of a rhodium(i) germyl complex: a useful tool for C-H and C-F bond activation reactions. Dalton Trans. 2016;45:4716-28 pubmed publisher
    The dihydrido germyl complex cis,fac-[Rh(GePh3)(H)2(PEt3)3] (2) was synthesized by an oxidative addition of HGePh3 at [Rh(H)(PEt3)3] (1). Treatment of 2 with neohexene generated the rhodium(i) germyl complex [Rh(GePh3)(PEt3)3] (3)...
  37. Wedding J, Harris H, Bader C, Plush S, Mak R, Massi M, et al. Intracellular distribution and stability of a luminescent rhenium(i) tricarbonyl tetrazolato complex using epifluorescence microscopy in conjunction with X-ray fluorescence imaging. Metallomics. 2017;9:382-390 pubmed publisher
    ..fluorescence imaging to monitor the stability and intracellular distribution of the luminescent rhenium(i) complex fac-[Re(CO)3(phen)L], where phen = 1,10-phenathroline and L = 5-(4-iodophenyl)tetrazolato, in 22Rv1 cells...
  38. Turnbull G, Williams J, Kozhevnikov V. Rigidly linking cyclometallated Ir(iii) and Pt(ii) centres: an efficient approach to strongly absorbing and highly phosphorescent red emitters. Chem Commun (Camb). 2017;53:2729-2732 pubmed publisher
    The synthesis and photophysical properties of an unprecedented tetranuclear complex are described, in which a fac-tris-cyclometallated Ir(iii) centre is rigidly connected to three cyclometallated Pt(ii) centres...
  39. Lee D, Park J, Lee H, Lee S, Lee D. Iron overload-induced calcium signals modulate mitochondrial fragmentation in HT-22 hippocampal neuron cells. Toxicology. 2016;365:17-24 pubmed publisher
    ..mitochondrial fragmentation in HT-22 hippocampal neuron cells that were incubated with ferric ammonium citrate (FAC)...
  40. Kaushik P, Dowling K, Adhikari R, Barrow C, Adhikari B. Effect of extraction temperature on composition, structure and functional properties of flaxseed gum. Food Chem. 2017;215:333-40 pubmed publisher
    ..index (EAI) and emulsion stability index (ESI), water absorption capacity (WAC) and fat absorption capacity (FAC) of FG samples, were also investigated as a function of extraction temperature...
  41. Younan D, Griffin R, Reiff D, Richey J, Schinnerer E, Pittet J, et al. Echocardiographic correlates are associated with in-hospital mortality in trauma and burn patients. Am J Surg. 2017;214:798-803 pubmed publisher
    ..We report the association of end diastolic area (EDA) and fractional area of change (FAC) with mortality in a cohort of trauma and burn patients...
  42. Kilcommons L, Redmon R, Knipp D. A New DMSP Magnetometer & Auroral Boundary Dataset and Estimates of Field Aligned Currents in Dynamic Auroral Boundary Coordinates. J Geophys Res Space Phys. 2017;122:9068-9079 pubmed publisher
    ..Finally, we demonstrate the potential of this new dataset by estimating field-aligned current (FAC) density using the Minimum Variance Analysis (MVA) technique...
  43. Felsenstein K, Theodorescu D. Precision medicine for urothelial bladder cancer: update on tumour genomics and immunotherapy. Nat Rev Urol. 2017;: pubmed publisher
    ..For example, DNA repair pathway mutations in genes such as ERCC2, FANCC, ATM, RB1, and others can predict responses to neoadjuvant platinum-based chemotherapies and to targeted therapies ..
  44. Kupfer G, Naf D, Suliman A, Pulsipher M, D Andrea A. The Fanconi anaemia proteins, FAA and FAC, interact to form a nuclear complex. Nat Genet. 1997;17:487-90 pubmed
    ..The two cloned FA genes, FAA and FAC, encode proteins that are unrelated to each other or to other proteins in GenBank...
  45. Chua J, Culpan J, Menon E. Efficacy of an Electromechanical Gait Trainer Poststroke in Singapore: A Randomized Controlled Trial. Arch Phys Med Rehabil. 2016;97:683-90 pubmed publisher
    ..The primary outcome was the Functional Ambulation Category (FAC). Secondary outcomes were the Barthel Index (BI), gait speed and endurance, and Stroke Impact Scale (SIS)...
  46. Brooks J, Watson A, Korcsmáros T. Omics Approaches to Identify Potential Biomarkers of Inflammatory Diseases in the Focal Adhesion Complex. Genomics Proteomics Bioinformatics. 2017;15:101-109 pubmed publisher
    ..The focal adhesion complex (FAC) has been implicated in the pathogenesis of multiple inflammatory diseases, including IBD, rheumatoid arthritis, ..
  47. Rao G, Jamshidi M, Dawkins J, Pell W, Korobkov I, Richeson D. Electrocatalytic generation of H2 from neutral water in acetonitrile using manganese polypyridyl complexes with ligand assistance. Dalton Trans. 2017;46:6518-6522 pubmed publisher
    A Mn(i) tris(2-pyridylmethyl)amine complex fac-[Mn(κ3-tpa) (CO)3]+OTf- carries out electrocatalytic hydrogen evolution from neutral water in acetonitrile...
  48. Malafarina V, Uriz Otano F, Malafarina C, Martinez J, Zulet M. Effectiveness of nutritional supplementation on sarcopenia and recovery in hip fracture patients. A multi-centre randomized trial. Maturitas. 2017;101:42-50 pubmed publisher
    ..Patients' functional situation was evaluated using the Barthel index (BI) and the Functional Ambulation Categories (FAC) score...
  49. Liu W, Cao W, Zhang J, Qiao Q, Ma H. Seismic Performance of Composite Shear Walls Constructed Using Recycled Aggregate Concrete and Different Expandable Polystyrene Configurations. Materials (Basel). 2016;9: pubmed publisher
    ..shear walls consisted of an ordinary recycled concrete shear wall, a composite wall with fine aggregate concrete (FAC) protective layer (EPS modules as the external insulation layer), and a composite wall with sandwiched EPS modules ..
  50. Liu X, Wu Z, Zhang Z, Liu P, Sun P. Synthesis of trifluoroalkyl or difluoroalkyl phenanthridine derivatives via cascade reaction using an intramolecular cyano group as a radical acceptor under photoredox catalysis. Org Biomol Chem. 2018;16:414-423 pubmed publisher
    In the presence of Ru(phen)3Cl2 or fac-Ir(ppy)3 under visible-light irradiation, the addition of fluorinated radicals to N-arylacrylamides followed by an intramolecular cyano group insertion cascade ..
  51. Hamada S, Fromentin M, Ronot M, Gauss T, Harrois A, Duranteau J, et al. Femoral arterial and central venous catheters in the trauma resuscitation room. Injury. 2018;49:927-932 pubmed publisher
    Arterial and central venous femoral catheters (fAC-CVC) use during the initial management of severe trauma patients is not a standard technique in most trauma centers...
  52. Koren Michowitz M, Friedman E, Gershoni Baruch R, Brok Simoni F, Patael Y, Rechavi G, et al. Coinheritance of BRCA1 and BRCA2 mutations with Fanconi anemia and Bloom syndrome mutations in Ashkenazi Jewish population: possible role in risk modification for cancer development. Am J Hematol. 2005;78:203-6 pubmed
    ..Coinheritance of FA and/or BS mutations seems to be more prevalent among BRCA mutation carriers, but a larger study encompassing more women may help in clarifying this issue. ..
  53. Medhurst A, Laghmani E, Steltenpool J, Ferrer M, Fontaine C, de Groot J, et al. Evidence for subcomplexes in the Fanconi anemia pathway. Blood. 2006;108:2072-80 pubmed
    ..The interaction between FANCA and FANCL is dependent on FANCB, FANCG, and FANCM, but independent of FANCC, FANCE, and FANCF...
  54. Visser L, Scansen B, Brown N, Schober K, Bonagura J. Echocardiographic assessment of right ventricular systolic function in conscious healthy dogs following a single dose of pimobendan versus atenolol. J Vet Cardiol. 2015;17:161-72 pubmed publisher
    ..of RV systolic function included tricuspid annular plane systolic excursion (TAPSE), fractional area change (FAC), pulsed-wave tissue Doppler-derived systolic myocardial velocity of the lateral tricuspid annulus (S'), and ..
  55. Damy T, Costes B, Hagège A, Donal E, Eicher J, Slama M, et al. Prevalence and clinical phenotype of hereditary transthyretin amyloid cardiomyopathy in patients with increased left ventricular wall thickness. Eur Heart J. 2016;37:1826-34 pubmed publisher
    ..It is not known how often hereditary transthyretin-related familial amyloid cardiomyopathy (mTTR-FAC) is responsible for LVWT...
  56. Djekic D, Pinto R, Vorkas P, Henein M. Replication of LC-MS untargeted lipidomics results in patients with calcific coronary disease: An interlaboratory reproducibility study. Int J Cardiol. 2016;222:1042-1048 pubmed publisher
    Recently a lipidomics approach was able to identify perturbed fatty acyl chain (FAC) and sphingolipid moieties that could stratify patients according to the severity of coronary calcification, a form of subclinical atherosclerosis...
  57. Betti M, Casalone E, Ferrante D, Aspesi A, Morleo G, Biasi A, et al. Germline mutations in DNA repair genes predispose asbestos-exposed patients to malignant pleural mesothelioma. Cancer Lett. 2017;405:38-45 pubmed publisher
    ..Ten pathogenic truncating variants (PTVs) were identified in PALB2, BRCA1, FANCI, ATM, SLX4, BRCA2, FANCC, FANCF, PMS1 and XPC...
  58. Gibson R, Morgan N, Goldstein L, Pearson I, Kesterton I, Foot N, et al. Novel mutations and polymorphisms in the Fanconi anemia group C gene. Hum Mutat. 1996;8:140-8 pubmed
    ..At least four complementation groups have been defined, and the FA group C gene (FAC) has been cloned...
  59. Zhao H, Simpson P, Barlow A, Moxey G, Morshedi M, Roy N, et al. Syntheses, Spectroscopic, Electrochemical, and Third-Order Nonlinear Optical Studies of a Hybrid Tris{ruthenium(alkynyl)/(2-phenylpyridine)}iridium Complex. Chemistry. 2015;21:11843-54 pubmed publisher
    The synthesis of fac-[Ir{N,C1′-(2,2′-NC5H4C6H3-5′-C≡C-1-C6H2-3,5-Et2-4-C≡CC6H4-4-C≡CH)}3] (10), which bears pendant ethynyl groups, and its reaction with [RuCl(dppe)2]PF6 to afford the heterobimetallic ..
  60. Tseng T, Luo T, Liao S, Lu K, Lu K. Isorecticular Synthesis of Dissectible Molecular Bamboo Tubes of Hexarhenium(I) Benzene-1,2,3,4,5,6-hexaolate Complexes. Angew Chem Int Ed Engl. 2016;55:8343-7 pubmed publisher
    ..The MBs are composed of six fac-(CO)3 Re cores, one benzene-1,2,3,4,5,6-hexaolate plate, and six pyridine-derivative pillar ligands, which have a ..
  61. Strathdee C, Duncan A, Buchwald M. Evidence for at least four Fanconi anaemia genes including FACC on chromosome 9. Nat Genet. 1992;1:196-8 pubmed
    ..3 through in situ hybridization. These results suggest that mutations in at least four different genes lead to FA, a degree of genetic heterogeneity comparable to that of other DNA repair disorders. ..
  62. Zhang X, Li J, Sejas D, Rathbun K, Bagby G, Pang Q. The Fanconi anemia proteins functionally interact with the protein kinase regulated by RNA (PKR). J Biol Chem. 2004;279:43910-9 pubmed
    ..We have used a BM extract to show that three FA proteins, FANCA, FANCC, and FANCG, functionally interact with the PKR kinase, which in turn regulates translational control...
  63. Kowal P, Gurtan A, Stuckert P, D Andrea A, Ellenberger T. Structural determinants of human FANCF protein that function in the assembly of a DNA damage signaling complex. J Biol Chem. 2007;282:2047-55 pubmed
    ..FANCF mutants bearing amino acid substitutions in this C-terminal surface fail to interact with other components of the FA complex, indicating that this surface is critical for the proper assembly of the FA core complex. ..
  64. Hooks M, Turner J, Murphy E, Johnston K, Burr S, Jarosławski S. The Arabidopsis ALDP protein homologue COMATOSE is instrumental in peroxisomal acetate metabolism. Biochem J. 2007;406:399-406 pubmed
    ..Emerged seedlings of both cts-1 and pxa1 alleles displayed increased resistance to FAc (monofluoroacetic acid) compared with the corresponding wild-type seedlings...
  65. Du W, Li J, Sipple J, Chen J, Pang Q. Cytoplasmic FANCA-FANCC complex interacts and stabilizes the cytoplasm-dislocalized leukemic nucleophosmin protein (NPMc). J Biol Chem. 2010;285:37436-44 pubmed publisher
    ..Exogenous NPMc was degraded rapidly in FA acute myeloid leukemia bone marrow cells. Knockdown of FANCA or FANCC in leukemic OCI/AML3 cells induced rapid degradation of endogenous NPMc...
  66. Ghosh A, Ghosh S, Maiti G, Mukherjee S, Mukherjee N, Chakraborty J, et al. Association of FANCC and PTCH1 with the development of early dysplastic lesions of the head and neck. Ann Surg Oncol. 2012;19 Suppl 3:S528-38 pubmed publisher
    ..The aim of this study was to understand the association of candidate tumor suppressor genes PHF2, FANCC, PTCH1, and XPA located in this region in the development of HNSCC...
  67. Huard C, Tremblay C, Magron A, Levesque G, Carreau M. The Fanconi anemia pathway has a dual function in Dickkopf-1 transcriptional repression. Proc Natl Acad Sci U S A. 2014;111:2152-7 pubmed publisher
    ..Interestingly, we previously found that the Fanconi C protein (FANCC) interacts with the C-terminal-binding protein-1 (CtBP1) involved in transcriptional regulation...
  68. Osborn M, Gabriel R, Webber B, Defeo A, McElroy A, Jarjour J, et al. Fanconi anemia gene editing by the CRISPR/Cas9 system. Hum Gene Ther. 2015;26:114-26 pubmed publisher
    ..Collectively, we provide proof of principle for precision genome editing in Fanconi anemia, a DNA repair-deficient human disorder. ..
  69. Nagae M, Mishra S, Hanashima S, Tateno H, Yamaguchi Y. Distinct roles for each N-glycan branch interacting with mannose-binding type Jacalin-related lectins Orysata and Calsepa. Glycobiology. 2017;27:1120-1133 pubmed publisher
    ..comparison of N-glycan-binding preference for two mJRLs, Orysata and Calsepa using frontal affinity chromatography (FAC), X-ray and molecular modeling...
  70. Segal G, Magenis R, Brown M, Keeble W, Smith T, Heinrich M, et al. Repression of Fanconi anemia gene (FACC) expression inhibits growth of hematopoietic progenitor cells. J Clin Invest. 1994;94:846-52 pubmed
    ..We tested the hypothesis that the protein encoded by the FA group C complementing gene (FACC) plays a regulatory role in hematopoiesis...
  71. Kupfer G, Yamashita T, Naf D, Suliman A, Asano S, D Andrea A. The Fanconi anemia polypeptide, FAC, binds to the cyclin-dependent kinase, cdc2. Blood. 1997;90:1047-54 pubmed
    ..Although transfection of type-C FA cells with the FAC cDNA corrects these cellular abnormalities, the molecular function of the FAC polypeptide remains unknown...
  72. McMahon L, Walsh C, Lambert M. Human alpha spectrin II and the Fanconi anemia proteins FANCA and FANCC interact to form a nuclear complex. J Biol Chem. 1999;274:32904-8 pubmed
    ..These studies also show that alphaSpIISigma* forms a complex in the nucleus with the FANCA and FANCC proteins...
  73. de Winter J, van Der Weel L, de Groot J, Stone S, Waisfisz Q, Arwert F, et al. The Fanconi anemia protein FANCF forms a nuclear complex with FANCA, FANCC and FANCG. Hum Mol Genet. 2000;9:2665-74 pubmed
    ..Despite the identification of four of these genes (FANCA, FANCC, FANCF and FANCG), the nature of the 'FA pathway' has remained enigmatic, as the FA proteins lack sequence ..
  74. Medhurst A, Huber P, Waisfisz Q, de Winter J, Mathew C. Direct interactions of the five known Fanconi anaemia proteins suggest a common functional pathway. Hum Mol Genet. 2001;10:423-9 pubmed
    ..the previously described binding of FANCA to FANCG, we now demonstrate direct interaction of FANCF with FANCG, of FANCC with FANCE and a weaker interaction of FANCE with both FANCA and FANCG...
  75. Ling C, Ishiai M, Ali A, Medhurst A, Neveling K, Kalb R, et al. FAAP100 is essential for activation of the Fanconi anemia-associated DNA damage response pathway. EMBO J. 2007;26:2104-14 pubmed
    ..Our study identifies FAAP100 as a new critical component of the FA-BRCA DNA damage response network. ..
  76. Pace P, Mosedale G, Hodskinson M, Rosado I, Sivasubramaniam M, Patel K. Ku70 corrupts DNA repair in the absence of the Fanconi anemia pathway. Science. 2010;329:219-23 pubmed publisher
    ..We found a genetic interaction between the FA gene FANCC and the nonhomologous end joining (NHEJ) factor Ku70...
  77. Córdoba O, Llurba E, Cortes J, Sabadell M, Lirola J, Ferrer Q, et al. Complete pathological remission in a patient with hormone-receptor positive and c-erbB-2 expression-negative breast cancer treated with FAC chemotherapy during pregnancy. Tumori. 2010;96:629-32 pubmed
    ..Neoadjuvant FAC (fluorouracil, adriamycin, cytoxan) chemotherapy was started at 29 weeks' gestation...
  78. Kao W, Riker A, Kushwaha D, Ng K, Enkemann S, Jove R, et al. Upregulation of Fanconi anemia DNA repair genes in melanoma compared with non-melanoma skin cancer. J Invest Dermatol. 2011;131:2139-42 pubmed publisher
  79. El Ghrably I, Steel D, Habib M, Vaideanu Collins D, Manvikar S, Hillier R. Diabetic macular edema outcomes in eyes treated with fluocinolone acetonide 0.2 µg/d intravitreal implant: real-world UK experience. Eur J Ophthalmol. 2017;27:357-362 pubmed publisher
    ..2 µg/day fluocinolone acetonide (FAc) implant in the treatment of patients with chronic diabetic macular edema (DME) in 3 large hospital ophthalmology ..
  80. Russell J, Pillarsetty N, Kramer R, Romesser P, Desai P, Haimovitz Friedman A, et al. In Vitro and In Vivo Comparison of Gemcitabine and the Gemcitabine Analog 1-(2'-deoxy-2'-fluoroarabinofuranosyl) Cytosine (FAC) in Human Orthotopic and Genetically Modified Mouse Pancreatic Cancer Models. Mol Imaging Biol. 2017;19:885-892 pubmed publisher
    ..1-(2'-deoxy-2'-fluoroarabinofuranosyl) cytosine (FAC), is an analog of gemcitabine, and when labeled with F-18, it may be a potential surrogate PET tracer for the drug...
  81. Rosado Toro J, Abidov A, Altbach M, Oliva I, Rodriguez J, Avery R. Segmentation of the right ventricle in four chamber cine cardiac MR images using polar dynamic programming. Comput Med Imaging Graph. 2017;62:15-25 pubmed publisher
    ..first looks at mutual overlap metrics and then focuses on clinical measures such as fractional area change (FAC). The mean mutual overlap between the physician's traces ranged from 0.85 to 0.88...
  82. Fandzloch M, Arriaga J, Sánchez Moreno M, Wojtczak A, Jezierska J, Sitkowski J, et al. Strategies for overcoming tropical disease by ruthenium complexes with purine analog: Application against Leishmania spp. and Trypanosoma cruzi. J Inorg Biochem. 2017;176:144-155 pubmed publisher
    ..with a bioactive molecule, the purine analogue 5,6,7-trimethyl-1,2,4-triazolo[1,5-a]pyrimidine (tmtp): cis,fac-[RuCl2(dmso)3(tmtp)] (1), mer-[RuCl3(dmso)(H2O)(tmtp)]·2H2..
  83. Tsuji H. Molecular function of florigen. Breed Sci. 2017;67:327-332 pubmed publisher
    ..revealed the precise distribution of florigen and transcriptional targets of the florigen activation complex (FAC) during early stages of floral transition...
  84. Rico J, Zang Y, Haughey N, Rius A, McFadden J. Short communication: Circulating fatty acylcarnitines are elevated in overweight periparturient dairy cows in association with sphingolipid biomarkers of insulin resistance. J Dairy Sci. 2018;101:812-819 pubmed publisher
    ..Surplus fatty acids (FA) and defects in FA oxidation favor the accumulation of fatty acylcarnitines (FAC) and the sphingolipid ceramide...
  85. Scherbinina S, Fedorov O, Levin V, Kokorekin V, Struchkova M, Dilman A. Synthesis of 3-Fluoropyridines via Photoredox Mediated Coupling of ?,?-Difluoro-?-iodoketones with Silyl Enol Ethers. J Org Chem. 2017;: pubmed publisher
    ..The reaction involves photoredox coupling of ?,?-difluoro-?-iodoketones with silyl enol ethers catalyzed by fac-Ir(ppy)3 under blue LED irradiation with subsequent one-pot condensation with ammonium acetate...
  86. Murer Orlando M, Llerena J, Birjandi F, Gibson R, Mathew C. FACC gene mutations and early prenatal diagnosis of Fanconi's anaemia. Lancet. 1993;342:686 pubmed
  87. Kruyt F, Hoshino T, Liu J, Joseph P, Jaiswal A, Youssoufian H. Abnormal microsomal detoxification implicated in Fanconi anemia group C by interaction of the FAC protein with NADPH cytochrome P450 reductase. Blood. 1998;92:3050-6 pubmed
    The FAC protein encoded by the Fanconi anemia (FA) complementation group C gene is thought to function in the cytoplasm at a step before DNA repair...
  88. Hoatlin M, Zhi Y, Ball H, Silvey K, Melnick A, Stone S, et al. A novel BTB/POZ transcriptional repressor protein interacts with the Fanconi anemia group C protein and PLZF. Blood. 1999;94:3737-47 pubmed
    ..We have isolated a binding partner for the Fanconi anemia group C protein (FANCC) by yeast two-hybrid screening...
  89. Kuang Y, Garcia Higuera I, Moran A, Mondoux M, Digweed M, D Andrea A. Carboxy terminal region of the Fanconi anemia protein, FANCG/XRCC9, is required for functional activity. Blood. 2000;96:1625-32 pubmed
    ..Four of the FA genes have been cloned, and at least three of the encoded proteins, FANCA, FANCC, and FANCG/XRCC9, interact in a nuclear complex, required for the maintenance of normal chromosome stability...
  90. McMahon L, Sangerman J, Goodman S, Kumaresan K, Lambert M. Human alpha spectrin II and the FANCA, FANCC, and FANCG proteins bind to DNA containing psoralen interstrand cross-links. Biochemistry. 2001;40:7025-34 pubmed
    ..of DNA interstrand cross-links and have shown that it forms a complex with the Fanconi anemia proteins FANCA, FANCC, and FANCG...
  91. Adachi D, Oda T, Yagasaki H, Nakasato K, Taniguchi T, D Andrea A, et al. Heterogeneous activation of the Fanconi anemia pathway by patient-derived FANCA mutants. Hum Mol Genet. 2002;11:3125-34 pubmed
    ..of MMC sensitivity and for reconstitution of the FA pathway: FANCA phosphorylation, interaction with FANCC, FANCF and FANCG and nuclear localization and FANCD2 monoubiquitination...
  92. Li X, Plett P, Yang Y, Hong P, Freie B, Srour E, et al. Fanconi anemia type C-deficient hematopoietic stem/progenitor cells exhibit aberrant cell cycle control. Blood. 2003;102:2081-4 pubmed
    ..Here, we used Fanconi anemia complementation type C-deficient (Fancc-/-) mice to demonstrate that Fancc-/- phenotypically defined cell populations enriched for hematopoietic stem and ..