Gene Symbol: FAM96B
Description: family with sequence similarity 96 member B
Alias: CGI-128, CIA2B, MIP18, mitotic spindle-associated MMXD complex subunit MIP18, MSS19-interacting protein of 18 kDa
Species: human
Products:     FAM96B

Top Publications

  1. Gari K, León Ortiz A, Borel V, Flynn H, Skehel J, Boulton S. MMS19 links cytoplasmic iron-sulfur cluster assembly to DNA metabolism. Science. 2012;337:243-5 pubmed publisher
    ..Here, we demonstrate that MMS19 forms a complex with the cytoplasmic Fe-S assembly (CIA) proteins CIAO1, IOP1, and MIP18. Cytoplasmic MMS19 also binds to multiple nuclear Fe-S proteins involved in DNA metabolism...
  2. van Wietmarschen N, Moradian A, Morin G, Lansdorp P, Uringa E. The mammalian proteins MMS19, MIP18, and ANT2 are involved in cytoplasmic iron-sulfur cluster protein assembly. J Biol Chem. 2012;287:43351-8 pubmed publisher
    ..In addition, we show that mitotic spindle-associated MMXD complex subunit MIP18 also interacts with both CIAO1 and Fe-S proteins...
  3. Ito S, Tan L, Andoh D, Narita T, Seki M, Hirano Y, et al. MMXD, a TFIIH-independent XPD-MMS19 protein complex involved in chromosome segregation. Mol Cell. 2010;39:632-40 pubmed publisher
    ..However, the MMS19-XPD complex did not contain any other subunits of TFIIH. Instead, it included FAM96B (now designated MIP18), Ciao1, and ANT2. MMS19, MIP18, and XPD localized to the mitotic spindle during mitosis...
  4. Stehling O, Mascarenhas J, Vashisht A, Sheftel A, Niggemeyer B, Rösser R, et al. Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and maturation of different subsets of cytosolic-nuclear iron-sulfur proteins. Cell Metab. 2013;18:187-98 pubmed publisher
    ..Here, we identify and characterize human CIA2A (FAM96A), CIA2B (FAM96B), and CIA1 (CIAO1) as components of the cytosolic Fe/S protein assembly (CIA) machinery...
  5. Lev I, Volpe M, Goor L, Levinton N, Emuna L, Ben Aroya S. Reverse PCA, a systematic approach for identifying genes important for the physical interaction between protein pairs. PLoS Genet. 2013;9:e1003838 pubmed publisher
    ..This method will facilitate the study of protein structure-function relationships, and may help in elucidating the mechanisms that regulate PPIs. ..
  6. Yang W, Itoh F, Ohya H, Kishimoto F, Tanaka A, Nakano N, et al. Interference of E2-2-mediated effect in endothelial cells by FAM96B through its limited expression of E2-2. Cancer Sci. 2011;102:1808-14 pubmed publisher
    ..However, it is unclear how the activity of E2-2 is controlled in the cells. In this study, we identified FAM96B as an interaction partner of E2-2. FAM96B interfered with E2-2-mediated effects on luciferase reporter activities...
  7. Xiong X, Wang J, Zheng H, Jing X, Liu Z, Zhou Z, et al. Identification of FAM96B as a novel prelamin A binding partner. Biochem Biophys Res Commun. 2013;440:20-4 pubmed publisher
    ..screen using a human skeletal muscle cDNA library to search for prelamin A binding partners, and identified FAM96B as a prelamin A binding partner...
  8. Upadhyay A, Stehling O, Panayiotou C, Rösser R, Lill R, Overby A. Cellular requirements for iron-sulfur cluster insertion into the antiviral radical SAM protein viperin. J Biol Chem. 2017;292:13879-13889 pubmed publisher
    ..In the CIA pathway, CIA1 cooperates with CIA2A, CIA2B, and MMS19 targeting factors to form various complexes that mediate the dedicated maturation of specific Fe/S ..
  9. Zhao B, Velasco K, Sompallae R, Pfirrmann T, Masucci M, Lindsten K. The ubiquitin specific protease-4 (USP4) interacts with the S9/Rpn6 subunit of the proteasome. Biochem Biophys Res Commun. 2012;427:490-6 pubmed publisher
    ..Thus, the interaction with USP4 may regulate the structure and function of the proteasome or the turnover of specific proteasomal substrates. ..

More Information


  1. Hultquist J, Schumann K, Woo J, Manganaro L, McGregor M, DOUDNA J, et al. A Cas9 Ribonucleoprotein Platform for Functional Genetic Studies of HIV-Host Interactions in Primary Human T Cells. Cell Rep. 2016;17:1438-1452 pubmed publisher
    ..This technology should accelerate target validation for pharmaceutical and cell-based therapies to cure HIV infection. ..
  2. Odermatt D, Gari K. The CIA Targeting Complex Is Highly Regulated and Provides Two Distinct Binding Sites for Client Iron-Sulfur Proteins. Cell Rep. 2017;18:1434-1443 pubmed publisher
    ..Here, we show that the complex members MIP18 and CIAO1 associate with the C terminus of MMS19...