Gene Symbol: FAM83A
Description: family with sequence similarity 83 member A
Alias: BJ-TSA-9, protein FAM83A, tumor antigen BJ-TSA-9, tumor-specific gene expressed in prostate protein
Species: human
Products:     FAM83A

Top Publications

  1. Lee S, Meier R, Furuta S, Lenburg M, Kenny P, Xu R, et al. FAM83A confers EGFR-TKI resistance in breast cancer cells and in mice. J Clin Invest. 2012;122:3211-20 pubmed publisher
    ..a screen to measure reversion of malignant cells into phenotypically nonmalignant cells in 3D gels, we identified FAM83A as a candidate cancer-associated gene capable of conferring resistance to EGFR-TKIs...
  2. Cipriano R, Miskimen K, Bryson B, Foy C, Bartel C, Jackson M. Conserved oncogenic behavior of the FAM83 family regulates MAPK signaling in human cancer. Mol Cancer Res. 2014;12:1156-65 pubmed publisher
    ..Furthermore, modeling the observed tumor expression of FAM83A, FAM83C, FAM83D, or FAM83E promoted human mammary epithelial cell (HMEC) transformation, which correlated with the ..
  3. Li Y, Dong X, Yin Y, Su Y, Xu Q, Zhang Y, et al. BJ-TSA-9, a novel human tumor-specific gene, has potential as a biomarker of lung cancer. Neoplasia. 2005;7:1073-80 pubmed
    ..Thus, BJ-TSA-9 may serve as a marker for lung cancer diagnosis and as a marker, in combination with two other tumor markers, for the prediction of the recurrence and prognosis of lung cancer patients. ..
  4. Liu L, Liao G, He P, Zhu H, Liu P, Qu Y, et al. Detection of circulating cancer cells in lung cancer patients with a panel of marker genes. Biochem Biophys Res Commun. 2008;372:756-60 pubmed publisher
    ..Positivity of more than one marker predicted a poor response to therapy and short survival time in non-small cell lung cancer patients. ..
  5. Olden M, Corre T, Hayward C, Toniolo D, Ulivi S, Gasparini P, et al. Common variants in UMOD associate with urinary uromodulin levels: a meta-analysis. J Am Soc Nephrol. 2014;25:1869-82 pubmed publisher
    ..These data indicate that common variants in the UMOD promoter region may influence urinary uromodulin levels. They also provide insights into uromodulin biology and the association of UMOD variants with renal function. ..
  6. Bartel C, Jackson M. HER2-positive breast cancer cells expressing elevated FAM83A are sensitive to FAM83A loss. PLoS ONE. 2017;12:e0176778 pubmed publisher
    ..Identifying new ways to target HER2 signaling will be critical for overcoming trastuzumab resistance. FAM83A is a novel oncogene identified by its ability to confer resistance to EGFR therapies, a receptor closely related ..