Gene Symbol: FAM3C
Description: family with sequence similarity 3 member C
Alias: GS3786, ILEI, protein FAM3C, interleukin-like EMT inducer, interleukin-like epithelial-mesenchymal transition inducer
Species: human
Products:     FAM3C

Top Publications

  1. Cho Y, Go M, Kim Y, Heo J, Oh J, Ban H, et al. A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits. Nat Genet. 2009;41:527-34 pubmed publisher
    ..On chromosome 7q31, rs7776725 (within the FAM3C gene) was associated with bone density at the radius (P = 1.0 x 10(-11)), tibia (P = 1.6 x 10(-6)) and heel (P = 1...
  2. Medina Gomez C, Kemp J, Estrada K, Eriksson J, Liu J, Reppe S, et al. Meta-analysis of genome-wide scans for total body BMD in children and adults reveals allelic heterogeneity and age-specific effects at the WNT16 locus. PLoS Genet. 2012;8:e1002718 pubmed publisher
    ..Our life-course approach postulates that these genetic effects influencing peak bone mass accrual may impact the risk of osteoporosis later in life. ..
  3. Song Q, Sheng W, Zhang X, Jiao S, Li F. ILEI drives epithelial to mesenchymal transition and metastatic progression in the lung cancer cell line A549. Tumour Biol. 2014;35:1377-82 pubmed publisher
    ..described post-transcriptional pathway by which TGF-? modulates expression of interleukin-like EMT inducer (ILEI), and EMT itself...
  4. Waerner T, Alacakaptan M, Tamir I, Oberauer R, Gal A, Brabletz T, et al. ILEI: a cytokine essential for EMT, tumor formation, and late events in metastasis in epithelial cells. Cancer Cell. 2006;10:227-39 pubmed
    ..mechanisms, expression profiling for EMT-specific genes identified a secreted interleukin-related protein (ILEI), upregulated exclusively at the translational level...
  5. Zhu Y, Xu G, Patel A, McLaughlin M, Silverman C, Knecht K, et al. Cloning, expression, and initial characterization of a novel cytokine-like gene family. Genomics. 2002;80:144-50 pubmed
    ..There are four genes in this family, FAM3A, FAM3B, FAM3C, and FAM3D, each encoding a protein (224-235 amino acids) with a hydrophobic leader sequence...
  6. Woosley A, Dalton A, Hussey G, Howley B, Mohanty B, Grelet S, et al. TGFβ promotes breast cancer stem cell self-renewal through an ILEI/LIFR signaling axis. Oncogene. 2019;: pubmed publisher
    b>FAM3C/Interleukin-like EMT Inducer (ILEI) is an oncogenic member of the FAM3 cytokine family and serves essential roles in both epithelial-mesenchymal transition (EMT) and breast cancer metastasis...
  7. Wu C, Xiao Y, Li H, Mao L, Deng W, Yu G, et al. Overexpression of FAM3C is associated with poor prognosis in oral squamous cell carcinoma. Pathol Res Pract. 2019;215:772-778 pubmed publisher
    Expression of the family with sequence similarity 3 member C (FAM3C) is necessary for the epithelial-mesenchymal transition (EMT)...
  8. Shi M, Duan G, Nie S, Shen S, Zou X. Elevated FAM3C promotes cell epithelial- mesenchymal transition and cell migration in gastric cancer. Onco Targets Ther. 2018;11:8491-8505 pubmed publisher
    ..Family with sequence similarity 3 member C (FAM3C) is known to play a critical role in inducing epithelial-mesenchymal transition in several cancer types, while its ..
  9. Zhang L, Choi H, Estrada K, Leo P, Li J, Pei Y, et al. Multistage genome-wide association meta-analyses identified two new loci for bone mineral density. Hum Mol Genet. 2014;23:1923-33 pubmed publisher
    ..3 (FGFRL1), 4q22.1 (MEPE), 5q14.3 (MEF2C), 6q25.1 (C6orf97, ESR1), 7q21.3 (FLJ42280, SHFM1), 7q31.31 (FAM3C, WNT16), 8q24.12 (TNFRSF11B), 11p15.3 (SOX6), 11q13.4 (LRP5), 13q14.11 (AKAP11) and 16q24 (FOXL1)...

More Information


  1. Montalvany Antonucci C, Zicker M, Ferreira A, Macari S, Ramos Junior E, Gomez R, et al. High-fat diet disrupts bone remodeling by inducing local and systemic alterations. J Nutr Biochem. 2018;59:93-103 pubmed publisher
    ..The HF diet modulated the expression of 30 inflammatory genes in AB such as Fam3c, InhBa, Tnfs11, Ackr2, Pxmp2 and Chil3, which are related to the inflammatory response and bone remodeling...
  2. Martínez Gil N, Roca Ayats N, Monistrol Mula A, Garcia Giralt N, Diez Perez A, Nogues X, et al. Common and rare variants of WNT16, DKK1 and SOST and their relationship with bone mineral density. Sci Rep. 2018;8:10951 pubmed publisher
    ..We have found six variants nominally associated with BMD, of which 2 WNT16 variants predicted to be eQTLs for FAM3C (rs55710688, in the Kozak sequence and rs142005327, within a putative enhancer) withstood multiple-testing ..
  3. Zheng H, Tobias J, Duncan E, Evans D, Eriksson J, Paternoster L, et al. WNT16 influences bone mineral density, cortical bone thickness, bone strength, and osteoporotic fracture risk. PLoS Genet. 2012;8:e1002745 pubmed publisher
    ..SNP rs7776725 in FAM3C, a gene adjacent to WNT16, was associated with a genome-wide significant increased risk of forearm fracture (OR = ..
  4. Halberg N, Sengelaub C, Navrazhina K, Molina H, Uryu K, Tavazoie S. PITPNC1 Recruits RAB1B to the Golgi Network to Drive Malignant Secretion. Cancer Cell. 2016;29:339-353 pubmed publisher
    ..release drives metastasis by increasing the secretion of pro-invasive and pro-angiogenic mediators HTRA1, MMP1, FAM3C, PDGFA, and ADAM10...
  5. Maatta J, Bendre A, Laanti M, Buki K, Rantakari P, Tervola P, et al. Fam3c modulates osteogenic cell differentiation and affects bone volume and cortical bone mineral density. Bonekey Rep. 2016;5:787 pubmed publisher
    b>Fam3c, a cytokine-like growth factor, has been suggested to have a role in epithelial-to-mesenchymal transition (EMT), tumor growth and metastasis...
  6. Bendre A, Büki K, Määttä J. Fam3c modulates osteogenic differentiation by down-regulating Runx2. Differentiation. 2017;93:50-57 pubmed publisher
    b>Fam3c, a cytokine-like protein, is a member of the Fam3 family (family with sequence similarity 3) and has been implicated to play a crucial role in Epithelial-to- mesenchymal transition (EMT) and subsequent metastasis during cancer ..
  7. Cushman D, Teramoto M, Curtis B, Lee D, Marcolina A, McCormick Z. Does Trainee Involvement in Fluoroscopic Injections Affect Fluoroscopic Time, Immediate Pain Reduction, and Complication Rate?. PM R. 2017;9:1013-1019 pubmed publisher
    ..guided hip (HI), sacroiliac joint (SIJI), transforaminal epidural (TFEI), and/or interlaminar epidural injections (ILEI, performed at only 1 institution)...
  8. Noguchi K, Dincman T, Dalton A, Howley B, McCall B, Mohanty B, et al. Interleukin-like EMT inducer (ILEI) promotes melanoma invasiveness and is transcriptionally up-regulated by upstream stimulatory factor-1 (USF-1). J Biol Chem. 2018;293:11401-11414 pubmed publisher
    Interleukin-like EMT inducer (ILEI, FAM3C) is a secreted factor that contributes to the epithelial-to-mesenchymal transition (EMT), a cell-biological process that confers metastatic properties to a tumor cell...
  9. Peng X, Xu E, Liang W, Pei X, Chen D, Zheng D, et al. Identification of FAM3D as a new endogenous chemotaxis agonist for the formyl peptide receptors. J Cell Sci. 2016;129:1831-42 pubmed publisher
    ..with sequence similarity 3 (FAM3) gene family is a cytokine-like gene family with four members FAM3A, FAM3B, FAM3C and FAM3D...
  10. Chen Z, Ding L, Yang W, Wang J, Chen L, Chang Y, et al. Hepatic Activation of the FAM3C-HSF1-CaM Pathway Attenuates Hyperglycemia of Obese Diabetic Mice. Diabetes. 2017;66:1185-1197 pubmed publisher
    b>FAM3C is a member of the family with sequence similarity 3 (FAM3) gene family, and this study determined its role and mechanism in regulation of hepatic glucose/lipid metabolism...
  11. Chesi A, Mitchell J, Kalkwarf H, Bradfield J, Lappe J, McCormack S, et al. A trans-ethnic genome-wide association study identifies gender-specific loci influencing pediatric aBMD and BMC at the distal radius. Hum Mol Genet. 2015;24:5053-9 pubmed publisher
    ..3 in males (P = 1.2 × 10(-8), β = 0.28 SD per G allele; BMC-Z). Signals at the CPED1-WNT16-FAM3C locus have been previously associated with BMD at other skeletal sites in adults and children...
  12. Csiszar A, Kutay B, Wirth S, Schmidt U, Macho Maschler S, Schreiber M, et al. Interleukin-like epithelial-to-mesenchymal transition inducer activity is controlled by proteolytic processing and plasminogen-urokinase plasminogen activator receptor system-regulated secretion during breast cancer progression. Breast Cancer Res. 2014;16:433 pubmed publisher
    Interleukin-like epithelial-to-mesenchymal transition inducer (ILEI) is an essential cytokine in tumor progression that is upregulated in several cancers, and its altered subcellular localization is a predictor of poor survival in human ..
  13. Sun Y, Jia X, Gao Q, Liu X, Hou L. The ubiquitin ligase UBE4A inhibits prostate cancer progression by targeting interleukin-like EMT inducer (ILEI). IUBMB Life. 2017;69:16-21 pubmed publisher
    ..Our initial evaluation of FAM3C (encoding ILEI) and ILEI expression in normal prostate (PCS-440-010) and prostate cancer cell lines (DU145, LNCaP, ..
  14. Gao Z, Lu C, Wang Z, Song Y, Zhu J, Gao P, et al. ILEI: a novel marker for epithelial-mesenchymal transition and poor prognosis in colorectal cancer. Histopathology. 2014;65:527-38 pubmed publisher
    ..In this study, we investigated the expression of interleukin-like EMT inducer (ILEI) and EMT-associated markers (E-cadherin, vimentin) in CRC tissues and determined the correlations between ILEI ..
  15. Kral M, Klimek C, Kutay B, Timelthaler G, Lendl T, Neuditschko B, et al. Covalent dimerization of interleukin-like epithelial-to-mesenchymal transition (EMT) inducer (ILEI) facilitates EMT, invasion, and late aspects of metastasis. FEBS J. 2017;284:3484-3505 pubmed publisher
    The interleukin-like epithelial-to-mesenchymal transition (EMT) inducer (ILEI)/FAM3C is a member of the highly homologous FAM3 family and is essential for EMT and metastasis formation...
  16. Noguchi K, Dalton A, Howley B, McCall B, Yoshida A, Diehl J, et al. Interleukin-like EMT inducer regulates partial phenotype switching in MITF-low melanoma cell lines. PLoS ONE. 2017;12:e0177830 pubmed publisher
    ILEI (FAM3C) is a secreted factor that contributes to the epithelial-to-mesenchymal transition (EMT), a cell biological process that confers metastatic properties to a tumor cell...
  17. Jansson A, Csiszar A, Maier J, Nyström A, Ax E, Johansson P, et al. The interleukin-like epithelial-mesenchymal transition inducer ILEI exhibits a non-interleukin-like fold and is active as a domain-swapped dimer. J Biol Chem. 2017;292:15501-15511 pubmed publisher
    Production and secretion of pro-metastatic proteins is a feature of many tumor cells. The FAM3C interleukin-like epithelial-to-mesenchymal-transition (EMT) inducer (ILEI) has been shown to be strongly up-regulated in several cancers and ..
  18. Zhang L, Hu H, Liu Y, Li J, Yu P, Zhang F, et al. A follow-up association study of two genetic variants for bone mineral density variation in Caucasians. Osteoporos Int. 2012;23:1867-75 pubmed publisher
    ..In addition, we found that rs7776725 was associated with BMD at the hip, spine and whole body. At the FAM3C gene locus where rs7776725 was located, we identified several other SNPs (rs4727922, rs1803389, rs718766 and ..
  19. Guo J, Cheng H, Zhao S, Yu L. GG: a domain involved in phage LTF apparatus and implicated in human MEB and non-syndromic hearing loss diseases. FEBS Lett. 2006;580:581-4 pubmed
    ..Tmem2 proteins, with two well-conserved glycine residues), present in eukaryotic FAM3 superfamily (FAM3A, FAM3B, FAM3C and FAM3D), POMGnT1 (protein O-linked mannose beta-1,2-N-acetylglucosaminyltransferase), TEM2 proteins as well as ..
  20. Mauri P, Scarpa A, Nascimbeni A, Benazzi L, Parmagnani E, Mafficini A, et al. Identification of proteins released by pancreatic cancer cells by multidimensional protein identification technology: a strategy for identification of novel cancer markers. FASEB J. 2005;19:1125-7 pubmed
    ..These include CSPG2/versican, Mac25/angiomodulin, IGFBP-1, HSPG2/perlecan, syndecan 4, FAM3C, APLP2, cyclophilin B, beta2 microglobulin, and ICA69...
  21. Zhu Y, Zhang B, Li M, Huang P, Sun J, Fu J, et al. Prognostic significance of FAM3C in esophageal squamous cell carcinoma. Diagn Pathol. 2015;10:192 pubmed publisher
    Family with sequence similarity 3, member C (FAM3C) has been identified as a novel regulator in epithelial-mesenchymal transition (EMT) and metastatic progression...
  22. Kemp J, Medina Gomez C, Estrada K, St Pourcain B, Heppe D, Warrington N, et al. Phenotypic dissection of bone mineral density reveals skeletal site specificity and facilitates the identification of novel loci in the genetic regulation of bone mass attainment. PLoS Genet. 2014;10:e1004423 pubmed publisher
    ..Allowing for these differences by performing genome-wide association at different skeletal sites may help uncover new genetic influences on BMD. ..
  23. Xiao F, Chen D, Lu Y, Xiao Z, Guan L, Yuan J, et al. Proteomic analysis of cerebrospinal fluid from patients with idiopathic temporal lobe epilepsy. Brain Res. 2009;1255:180-9 pubmed publisher
    ..vitamin D-binding protein (DBP) was elevated in the CSF of TLE patients whereas cathepsin D, apolipoprotein J, Fam3c, and superoxide dismutase 1 (SOD1) were decreased in the CSF of TLE patients...
  24. Grønborg M, Kristiansen T, Iwahori A, Chang R, Reddy R, Sato N, et al. Biomarker discovery from pancreatic cancer secretome using a differential proteomic approach. Mol Cell Proteomics. 2006;5:157-71 pubmed
    ..antigen, fibronectin receptor (integrin beta1), and a novel cytokine designated as predicted osteoblast protein (FAM3C). The differential expression of a subset of these novel proteins was validated by Western blot analysis...
  25. Liu L, Watanabe N, Akatsu H, Nishimura M. Neuronal expression of ILEI/FAM3C and its reduction in Alzheimer's disease. Neuroscience. 2016;330:236-46 pubmed publisher
    ..Previously, we reported that ILEI (also referred to as FAM3C) binds to the ?-secretase complex and suppresses A? production without inhibiting ?-secretase activity...
  26. Zhang X, Yang W, Wang J, Meng Y, Guan Y, Yang J. FAM3 gene family: A promising therapeutical target for NAFLD and type 2 diabetes. Metabolism. 2018;81:71-82 pubmed publisher
    ..The Family with sequence similarity 3 (FAM3) gene family consists of four members designated as FAM3A, FAM3B, FAM3C and FAM3D, respectively...
  27. Zhao X, Luo G, Fan Y, Ma X, Zhou J, Jiang H. ILEI is an important intermediate participating in the formation of TGF-β1-induced renal tubular EMT. Cell Biochem Funct. 2018;36:46-55 pubmed publisher
    ..A newly identified cytokine, interleukin-like EMT inducer (ILEI), has been linked to EMT in some diseases...