FAM20C

Summary

Gene Symbol: FAM20C
Description: FAM20C, golgi associated secretory pathway kinase
Alias: DMP-4, DMP4, G-CK, GEF-CK, RNS, extracellular serine/threonine protein kinase FAM20C, Golgi casein kinase, dentin matrix protein 4, family with sequence similarity 20, member C, golgi-enriched fraction casein kinase
Species: human
Products:     FAM20C

Top Publications

  1. Nalbant D, Youn H, Nalbant S, Sharma S, Cobos E, Beale E, et al. FAM20: an evolutionarily conserved family of secreted proteins expressed in hematopoietic cells. BMC Genomics. 2005;6:11 pubmed publisher
    ..proteins that has been named family with sequence similarity 20 (FAM20) with three members (FAM20A, FAM20B and FAM20C) in mammals...
  2. Hao J, Narayanan K, Muni T, Ramachandran A, George A. Dentin matrix protein 4, a novel secretory calcium-binding protein that modulates odontoblast differentiation. J Biol Chem. 2007;282:15357-65 pubmed
    ..Based on the nomenclature in our laboratory, this gene has been named dentin matrix protein 4 (DMP4)...
  3. Simpson M, Hsu R, Keir L, Hao J, Sivapalan G, Ernst L, et al. Mutations in FAM20C are associated with lethal osteosclerotic bone dysplasia (Raine syndrome), highlighting a crucial molecule in bone development. Am J Hum Genet. 2007;81:906-12 pubmed
    ..The region is delimited by marker D7S2563 and contains five transcriptional units. Sequence analysis of FAM20C, located within the deleted region, in six additional affected subjects revealed four homozygous mutations and two ..
  4. Simpson M, Scheuerle A, Hurst J, Patton M, Stewart H, Crosby A. Mutations in FAM20C also identified in non-lethal osteosclerotic bone dysplasia. Clin Genet. 2009;75:271-6 pubmed publisher
    ..and telomeric microdeletion in a patient with Raine syndrome and subsequently identified mutations in the FAM20C gene, located within the deleted region, in six additional Raine syndrome cases...
  5. Tagliabracci V, Engel J, Wen J, Wiley S, Worby C, Kinch L, et al. Secreted kinase phosphorylates extracellular proteins that regulate biomineralization. Science. 2012;336:1150-3 pubmed publisher
    ..Fam20C appears to be the Golgi casein kinase that phosphorylates secretory pathway proteins within S-x-E motifs...
  6. Ishikawa H, Xu A, Ogura E, Manning G, Irvine K. The Raine syndrome protein FAM20C is a Golgi kinase that phosphorylates bio-mineralization proteins. PLoS ONE. 2012;7:e42988 pubmed publisher
    ..The biochemical properties of FAM20C match those of an enzymatic activity known as Golgi casein kinase. Introduction of point mutations identified in Raine syndrome patients into recombinant FAM20C impairs its ..
  7. Ababneh F, Alswaid A, Youssef T, Al Azzawi M, Crosby A, Albalwi M. Hereditary deletion of the entire FAM20C gene in a patient with Raine syndrome. Am J Med Genet A. 2013;161A:3155-60 pubmed publisher
    Raine syndrome is an autosomal recessive disorder caused by mutations in the FAM20C gene that is characterized by generalized osteosclerosis with periosteal new bone formation and distinctive craniofacial dysmorphism...
  8. Takeyari S, Yamamoto T, Kinoshita Y, Fukumoto S, Glorieux F, Michigami T, et al. Hypophosphatemic osteomalacia and bone sclerosis caused by a novel homozygous mutation of the FAM20C gene in an elderly man with a mild variant of Raine syndrome. Bone. 2014;67:56-62 pubmed publisher
    ..growth factor 23 (FGF23) levels have been reported in young brothers with compound heterozygous mutations for the FAM20C gene; however, rickets was not observed in these cases...
  9. Fradin M, Stoetzel C, Muller J, Koob M, Christmann D, Debry C, et al. Osteosclerotic bone dysplasia in siblings with a Fam20C mutation. Clin Genet. 2011;80:177-83 pubmed publisher
    Raine syndrome is an autosomal recessive disorder caused by mutations in the FAM20C gene. FAM20C codes for the human homolog of DMP4, a dentin matrix protein highly expressed in odontoblasts and moderately in bone...

More Information

Publications133 found, 100 shown here

  1. Rafaelsen S, Raeder H, Fagerheim A, Knappskog P, Carpenter T, Johansson S, et al. Exome sequencing reveals FAM20c mutations associated with fibroblast growth factor 23-related hypophosphatemia, dental anomalies, and ectopic calcification. J Bone Miner Res. 2013;28:1378-85 pubmed publisher
    ..exome sequencing we identified compound heterozygous mutations in family with sequence similarity 20, member C (FAM20C) in two siblings referred for hypophosphatemia and severe dental demineralization disease...
  2. Prasanth M, Sivamaruthi B, Chaiyasut C, Tencomnao T. A Review of the Role of Green Tea (Camellia sinensis) in Antiphotoaging, Stress Resistance, Neuroprotection, and Autophagy. Nutrients. 2019;11: pubmed publisher
    ..or indirectly, by increased production of reactive oxygen species (ROS) and reactive nitrogen species (RNS)...
  3. Valko M, Jomova K, Rhodes C, Kuča K, Musílek K. Redox- and non-redox-metal-induced formation of free radicals and their role in human disease. Arch Toxicol. 2016;90:1-37 pubmed publisher
    ..oxygen species, ROS (via the Fenton reaction, which produces hydroxyl radicals), and reactive nitrogen species, RNS, which may cause oxidative damage to biological macromolecules such as DNA, proteins and lipids...
  4. Smallwood M, Nissim A, Knight A, Whiteman M, Haigh R, Winyard P. Oxidative stress in autoimmune rheumatic diseases. Free Radic Biol Med. 2018;125:3-14 pubmed publisher
    ..diseases, along with the excess production of reactive oxygen species (ROS) and reactive nitrogen species (RNS)...
  5. Kruk J, Kubasik Kladna K, Aboul Enein H. The Role Oxidative Stress in the Pathogenesis of Eye Diseases: Current Status and a Dual Role of Physical Activity. Mini Rev Med Chem. 2015;16:241-57 pubmed
    ..The most important oxidants are reactive oxygen species (ROS) and reactive nitrogen species (RNS) generated by various metabolic pathways, physical, chemical and biological factors, and pathological conditions...
  6. Tan C, Meng F, Reece E, Zhao Z. Modulation of nuclear factor-κB signaling and reduction of neural tube defects by quercetin-3-glucoside in embryos of diabetic mice. Am J Obstet Gynecol. 2018;219:197.e1-197.e8 pubmed publisher
    ..Quercetin-3-glucoside, a naturally occurring polyphenol that has high bioavailability and low toxicity, is a promising candidate agent to prevent birth defects in diabetic pregnancies. ..
  7. Huang J, Xiong K, Zhang H, Zhao Y, Cao J, Gong H, et al. Molecular characterization of Babesia microti thioredoxin (BmTrx2) and its expression patterns induced by antiprotozoal drugs. Parasit Vectors. 2018;11:38 pubmed publisher
    ..major weapons that is used in the resistance to the reactive oxygen species (ROS) and reactive nitrogen species (RNS) produced by host immune system...
  8. Jiang Y, Chang G, Wang Y, Zhang D, Cao L, Liu J. Geniposide Prevents Hypoxia/Reoxygenation-Induced Apoptosis in H9c2 Cells: Improvement of Mitochondrial Dysfunction and Activation of GLP-1R and the PI3K/AKT Signaling Pathway. Cell Physiol Biochem. 2016;39:407-21 pubmed publisher
    ..The production of reactive oxygen species/reactive nitrogen species (ROS/RNS), the level of mitochondrial calcium, and mitochondrial membrane potential depolarization were measured by confocal ..
  9. Makhafola T, Elgorashi E, McGaw L, Verschaeve L, Eloff J. The correlation between antimutagenic activity and total phenolic content of extracts of 31 plant species with high antioxidant activity. BMC Complement Altern Med. 2016;16:490 pubmed
    ..related to oxidative stress and DNA damage by reactive oxygen species (ROS) and reactive nitrogen species (RNS) have been identified in numerous human syndromes...
  10. Yahyapour R, Motevaseli E, Rezaeyan A, Abdollahi H, Farhood B, Cheki M, et al. Reduction-oxidation (redox) system in radiation-induced normal tissue injury: molecular mechanisms and implications in radiation therapeutics. Clin Transl Oncol. 2018;20:975-988 pubmed publisher
    ..Overproduction of reactive oxygen radicals (ROS), reactive hydroxyl radical (ROH) and reactive nitrogen radicals (RNS) in multiple cellular environments in the affected nucleus, cell membranes, cytosol and mitochondria, and other ..
  11. Hussein M, El Gizawy H, Gobba N, Mosaad Y. Synthesis of Cinnamyl and Caffeoyl Derivatives of Cucurbitacin-Eglycoside Isolated from Citrullus colocynthis Fruits and their Structures Antioxidant and Anti-inflammatory Activities Relationship. Curr Pharm Biotechnol. 2017;18:677-693 pubmed publisher
    ..total antioxidant, reducing power, anti-reactive oxygen species (ROS) and anti-reactive nitrogen species (RNS) were more pronounced in compound 3 compared to compounds (1-2)...
  12. Acuna Castroviejo D, Lopez L, Escames G, Lopez A, Garcia J, Reiter R. Melatonin-mitochondria interplay in health and disease. Curr Top Med Chem. 2011;11:221-40 pubmed
    ..but, in some instances it may react with superoxide anion radical to produce the toxic reactive nitrogen species (RNS), i.e. peroxynitrite anion, and the subsequent nitrosative damage...
  13. Patel B, Kumar P, Banerjee R, Basu M, Pal A, Samanta M, et al. Lactobacillus acidophilus attenuates Aeromonas hydrophila induced cytotoxicity in catla thymus macrophages by modulating oxidative stress and inflammation. Mol Immunol. 2016;75:69-83 pubmed publisher
    ..cellular injuries as evidenced by elevated levels of reactive oxygen species (ROS), reactive nitrogen species (RNS), increased apoptosis, DNA damage and decreased cellular viability...
  14. Borges C, Canani C, Fernandes C, Zanatta Ã, Seminotti B, Ribeiro C, et al. Reactive nitrogen species mediate oxidative stress and astrogliosis provoked by in vivo administration of phytanic acid in cerebellum of adolescent rats: A potential contributing pathomechanism of cerebellar injury in peroxisomal disorders. Neuroscience. 2015;304:122-32 pubmed publisher
    ..of GSH and the immunohistochemical alterations caused by Phyt, strongly suggesting that reactive nitrogen species (RNS) were involved in these effects...
  15. Guo Z, Liang Y, Yan J, Yang E, Li K, Xu H. Physiological response and transcription profiling analysis reveals the role of H2S in alleviating excess nitrate stress tolerance in tomato roots. Plant Physiol Biochem. 2018;124:59-69 pubmed publisher
    ..might enhance excess nitrate stress tolerance of tomato plants by modulating ROS and reactive nitrogen species (RNS) signaling and downstream transcriptional adjustment, such as defence response, signal transduction and ..
  16. Rana A, Singh D. Targeting glycogen synthase kinase-3 for oxidative stress and neuroinflammation: Opportunities, challenges and future directions for cerebral stroke management. Neuropharmacology. 2018;139:124-136 pubmed publisher
    ..enhances the oxidative stress by overproduction of reactive oxygen species (ROS) and reactive nitrogen species (RNS) from the neurons, as well as non-neuronal cells, thus further worsens the condition...
  17. Abdul Muneer P, Chandra N, Haorah J. Interactions of oxidative stress and neurovascular inflammation in the pathogenesis of traumatic brain injury. Mol Neurobiol. 2015;51:966-79 pubmed publisher
    ..or inability to balance antioxidant production with reactive oxygen species (ROS) and reactive nitrogen species (RNS) levels...
  18. Herrera Marschitz M, Perez Lobos R, Lespay Rebolledo C, Tapia Bustos A, Casanova Ortiz E, Morales P, et al. Targeting Sentinel Proteins and Extrasynaptic Glutamate Receptors: a Therapeutic Strategy for Preventing the Effects Elicited by Perinatal Asphyxia?. Neurotox Res. 2018;33:461-473 pubmed publisher
    ..one to the oxidative stress triggered by re-oxygenation, formation of reactive oxygen (ROS) and reactive nitrogen (RNS) species, and overactivation of glutamate receptors and mitochondrial deficiencies...
  19. Ahmad S, Mahmood R. Mercury chloride toxicity in human erythrocytes: enhanced generation of ROS and RNS, hemoglobin oxidation, impaired antioxidant power, and inhibition of plasma membrane redox system. Environ Sci Pollut Res Int. 2019;26:5645-5657 pubmed publisher
    ..These results show that HgCl2 induces oxidative and nitrosative stress, oxidizes hemoglobin, impairs the antioxidant defense mechanism, and alters metabolic pathways in human erythrocytes. ..
  20. Hajra S, Patra A, Basu A, Bhattacharya S. Prevention of doxorubicin (DOX)-induced genotoxicity and cardiotoxicity: Effect of plant derived small molecule indole-3-carbinol (I3C) on oxidative stress and inflammation. Biomed Pharmacother. 2018;101:228-243 pubmed publisher
    ..attenuated DOX-induced oxidative stress in the cardiac tissues as evident from decreased levels of ROS/RNS and lipid peroxidation, and by increased level of glutathione (reduced) and the activity of phase-II antioxidant ..
  21. Soloviev A, Kizub I. Mechanisms of vascular dysfunction evoked by ionizing radiation and possible targets for its pharmacological correction. Biochem Pharmacol. 2019;159:121-139 pubmed publisher
    ..oxide (NO)-mediated endothelium-dependent vasodilatation and generation of reactive oxygen (ROS) and nitrogen (RNS) species trigger this process...
  22. Chaki M, Álvarez de Morales P, Ruiz C, Begara Morales J, Barroso J, Corpas F, et al. Ripening of pepper (Capsicum annuum) fruit is characterized by an enhancement of protein tyrosine nitration. Ann Bot. 2015;116:637-47 pubmed publisher
    ..but more work is needed to detail the metabolic networks involving NO and other reactive nitrogen species (RNS) in the process...
  23. Kumawat M, Pesingi P, Agarwal R, Goswami T, Mahawar M. Contribution of protein isoaspartate methyl transferase (PIMT) in the survival of Salmonella Typhimurium under oxidative stress and virulence. Int J Med Microbiol. 2016;306:222-30 pubmed publisher
    ..is reversed by pharmacological inhibition of reactive oxygen species (ROS) but not reactive nitrogen species (RNS) production...
  24. Ahmadinejad F, Geir Møller S, Hashemzadeh Chaleshtori M, Bidkhori G, Jami M. Molecular Mechanisms behind Free Radical Scavengers Function against Oxidative Stress. Antioxidants (Basel). 2017;6: pubmed publisher
    ..Reactive oxygen and nitrogen species (ROS and RNS, respectively), collectively known as RONS, are produced by cellular enzymes such as myeloperoxidase, NADPH-oxidase ..
  25. Qian M, Lou Y, Wang Y, Zhang M, Jiang Q, Mo Y, et al. PICK1 deficiency exacerbates sepsis-associated acute lung injury and impairs glutathione synthesis via reduction of xCT. Free Radic Biol Med. 2018;118:23-34 pubmed publisher
    ..which was accompanied by increased production of reactive oxygen species (ROS) and reactive nitrogen species (RNS) and consumption of glutathione (GSH)...
  26. Ansari M, Roberts K, Scheff S. A time course of NADPH-oxidase up-regulation and endothelial nitric oxide synthase activation in the hippocampus following neurotrauma. Free Radic Biol Med. 2014;77:21-9 pubmed publisher
    ..The O2(•-) reacts with nitric oxide (NO), produces various reactive nitrogen species (RNS), and contributes to apoptotic cell death...
  27. Strutynska N, Kotsiuruba A, Budko A, Mys L, Sagach V. MITOCHONDRIAL DYSFUNCTION IN THE AGING HEART IS ACCOMPANIED BY CONSTITUTIVE NO-SYNTHASES UNCOUPLING ON THE BACKGROUND OF OXIDATIVE AND NITROSATIVE STRESS. Fiziol Zh. 2016;62:3-11 pubmed
    ..Thus, we observed the increased sensitivity of MPTP to calcium, due to decreased concentration of its inhibitors nitric oxide and hydrogen sulfide and increased levels of its inducers ROS and RNS in old rat heart mitochondria.
  28. Bertoldo J, Terenzi H. Oxidation and Tyrosine Nitration Induce Structural Changes and Inhibits Plasmodium falciparum Falcipain-2 Activity In Vitro. Protein Pept Lett. 2016;23:562-72 pubmed
    ..Many reports have indicated that radical nitrogen species (RNS) including nitric oxide (NO) are inhibitors of P. falciparum growth and promoters of recovery from malaria symptoms...
  29. Wang S, Irving G, Jiang L, Wang H, Li M, Wang X, et al. Oxidative Stress Mediated Hippocampal Neuron Apoptosis Participated in Carbon Disulfide-Induced Rats Cognitive Dysfunction. Neurochem Res. 2017;42:583-594 pubmed publisher
    ..Furthermore, extensive oxidative stress induced by CS2 was also revealed by the measurement of ROS, RNS, MDA, GSH&GSSG and antioxidant enzymes (CAT, T-SOD, and GSH-Px)...
  30. Kobeissy F, Guingab Cagmat J, BRUIJNZEEL A, Gold M, Wang K. Effect of Second-Hand Tobacco Smoke on the Nitration of Brain Proteins: A Systems Biology and Bioinformatics Approach. Methods Mol Biol. 2017;1598:353-372 pubmed publisher
    ..Oxidative stress is characterized by an increase in reactive oxygen and nitrogen species (ROS/RNS)...
  31. Bourret T, Liu L, Shaw J, Husain M, Vázquez Torres A. Magnesium homeostasis protects Salmonella against nitrooxidative stress. Sci Rep. 2017;7:15083 pubmed publisher
    ..of Salmonella in macrophages, and contributes to the resistance of this pathogen to reactive nitrogen species (RNS) generated from the nitric oxide produced by the inducible nitric oxide (NO) synthase of macrophages...
  32. Edwards S, Rubenstein L, Meredith L, Schmidt Hackbarth N, Stockdale S, Cordasco K, et al. Who is responsible for what tasks within primary care: Perceived task allocation among primary care providers and interdisciplinary team members. Healthc (Amst). 2015;3:142-9 pubmed publisher
    ..We performed a cross-sectional survey of PCPs and primary care staff (registered nurses (RNs), licensed practical/vocational nurses (LPNs), and medical assistants/clerks (MAs)) in 23 primary care practices ..
  33. Krasuska U, Andrzejczak O, Staszek P, Borucki W, Gniazdowska A. Toxicity of canavanine in tomato (Solanum lycopersicum L.) roots is due to alterations in RNS, ROS and auxin levels. Plant Physiol Biochem. 2016;103:84-95 pubmed publisher
    ..Modifications in the content of endogenous reactive nitrogen species (RNS) and reactive oxygen species (ROS) influence root structure and architecture, being also under hormonal control...
  34. Kim S, Park E, Han K, Kim S, Kim T. Nurse Staffing and 30-day Readmission of Chronic Obstructive Pulmonary Disease Patients: A 10-year Retrospective Study of Patient Hospitalization. Asian Nurs Res (Korean Soc Nurs Sci). 2016;10:283-288 pubmed publisher
    ..However, evidence on the effects of nurse staffing by registered nurses (RNs) on the readmission of COPD patients is lacking in Korea...
  35. Ahmad W, Ijaz B, Shabbiri K, Ahmed F, Rehman S. Oxidative toxicity in diabetes and Alzheimer's disease: mechanisms behind ROS/ RNS generation. J Biomed Sci. 2017;24:76 pubmed publisher
    ..We have also highlighted the role of current treatments that can be linked with reduced oxidative stress and damage in AD and T2DM. ..
  36. Pak O, Sydykov A, Kosanovic D, Schermuly R, Dietrich A, Schröder K, et al. Lung Ischaemia-Reperfusion Injury: The Role of Reactive Oxygen Species. Adv Exp Med Biol. 2017;967:195-225 pubmed publisher
    ..Alterations in the production of reactive oxygen species (ROS) and reactive nitrogen species (RNS) have been suggested as crucial mediators of such responses during ischaemia-reperfusion in the lung...
  37. Park C. Challenging Rules, Creating Values: Park's Sweet Spot Theory-driven Central-'Optimum Nurse Staffing Zone'. J Adv Nurs. 2017;: pubmed publisher
    ..plan to cut off funding for the Title VIII nursing workforce development programs" and "massive Registered Nurses' (RNs) retirements" in the United States (American Nurses Association, 2017; McMenamin, 2014), "Brexit" and allowance of "..
  38. Calzone K, Jenkins J, Culp S, Badzek L. Hospital nursing leadership-led interventions increased genomic awareness and educational intent in Magnet settings. Nurs Outlook. 2018;66:244-253 pubmed publisher
    ..This study assessed leadership team (administrator/educator) year-long interventions to improve registered nurses' (RNs) capacity to integrate genomics into practice. We examined genomic competency outcomes in 8,150 RNs...
  39. Leslie J, Lonneman W. Promoting Trust in the Registered Nurse-Patient Relationship. Home Healthc Now. 2016;34:38-42 pubmed publisher
    ..examine nursing literature to identify the antecedents, attributes, and outcomes of trusting relationships between RNs and patients in home healthcare...
  40. Garcia Guzman C, Fernandez A, Avlonitis N, Bradley M, Vendrell M. Red-Fluorescent Activatable Probes for the Detection of Hydrogen Peroxide in Living Cells. Comb Chem High Throughput Screen. 2016;19:353-61 pubmed
    ..of our probe upon incubation with H2O2 with good selectivity over different ROS and reactive nitrogen species (RNS) as well as minimal toxicity in cells...
  41. Shimizu T, Chiba T, Marusawa H. Helicobacter pylori-Mediated Genetic Instability and Gastric Carcinogenesis. Curr Top Microbiol Immunol. 2017;400:305-323 pubmed publisher
    ..Reactive oxygen species (ROS) and reactive nitrogen species (RNS) in inflammatory and gastric epithelial cells, as well as the expression of cytidine deaminase in gastric ..
  42. Staggs V. Injurious Assault Rates on Inpatient Psychiatric Units: Associations With Staffing by Registered Nurses and Other Nursing Personnel. Psychiatr Serv. 2015;66:1162-6 pubmed publisher
    The study examined associations between staffing levels by registered nurses (RNs) and non-RNs on psychiatric units and the rate of injurious assaults against hospital personnel, the rate of injurious assaults against other patients, and ..
  43. Franco M, López S, Medina R, Lucentini C, Troncozo M, Pastorino G, et al. The mitochondrial genome of the plant-pathogenic fungus Stemphylium lycopersici uncovers a dynamic structure due to repetitive and mobile elements. PLoS ONE. 2017;12:e0185545 pubmed publisher
    ..a circular double-stranded DNA molecule of 75,911 bp that harbors a set of 37 protein-coding genes, 2 rRNA genes (rns and rnl) and 28 tRNA genes, which are transcribed from both sense and antisense strands...
  44. Craft J, Christensen M, Wirihana L, Bakon S, Barr J, Tsai L. An integrative review of absenteeism in newly graduated nurses. Nurs Manag (Harrow). 2017;24:37-42 pubmed publisher
    ..also vital to consider the factors that influence absenteeism and turnover among newly graduated registered nurses (RNs), whose retention can help to address staff shortages...
  45. McNicholas A, McCall A, Werner A, Wounderly R, Marinchak E, Jones P. Improving Patient Experience Through Nursing Satisfaction. J Trauma Nurs. 2017;24:371-375 pubmed publisher
    ..Our findings demonstrated that, following APDF implementation, RNs felt more respected, stated that the trauma team was more collaborative, and, in addition, overall patient and ..
  46. Shuhendler A, Pu K, Cui L, Uetrecht J, Rao J. Real-time imaging of oxidative and nitrosative stress in the liver of live animals for drug-toxicity testing. Nat Biotechnol. 2014;32:373-80 pubmed publisher
    ..The production of radical species, specifically reactive oxygen species (ROS) and reactive nitrogen species (RNS), has been proposed as an early unifying event linking the bioactivation of drugs to hepatotoxicity and as a more ..
  47. Clavijo F, Diédhiou I, Vaissayre V, Brottier L, Acolatse J, Moukouanga D, et al. The Casuarina NIN gene is transcriptionally activated throughout Frankia root infection as well as in response to bacterial diffusible signals. New Phytol. 2015;208:887-903 pubmed publisher
    Root nodule symbioses (RNS) allow plants to acquire atmospheric nitrogen by establishing an intimate relationship with either rhizobia, the symbionts of legumes or Frankia in the case of actinorhizal plants...
  48. Miao F, Lim Z, Hu P, Dong S, Qi Q, Zhang X, et al. BODIPY blocked anthroxyl radicals: the substituent effect on reactivity and fluorescence turn-on detection of a hydroxyl radical. Org Biomol Chem. 2017;15:3188-3191 pubmed publisher
    ..4Me-BO-An-O was subjected to react with various reactive oxygen/nitrogen species (ROS/RNS) and selective fluorescence turn-on detection of a hydroxyl radical was achieved, validating the concept of "using ..
  49. Gi T, Devi K, Neo Kim E. A systematic review on the relationship between the nursing shortage and nurses' job satisfaction, stress and burnout levels in oncology/haematology settings. JBI Libr Syst Rev. 2011;9:1603-1649 pubmed
    ..Types of participants: This review considered studies that included oncology registered nurses (RNs) who were more than 18 years of age and worked in either inpatient or outpatient oncology/haematology wards or ..
  50. Zhang H, Zhu Q, Cui J, Wang Y, Chen M, Guo X, et al. Structure and evolution of the Fam20 kinases. Nat Commun. 2018;9:1218 pubmed publisher
    The Fam20 proteins are novel kinases that phosphorylate secreted proteins and proteoglycans. Fam20C phosphorylates hundreds of secreted proteins and is activated by the pseudokinase Fam20A...
  51. Nilsson J, Johansson E, Carlsson M, Florin J, Leksell J, Lepp M, et al. Disaster nursing: Self-reported competence of nursing students and registered nurses, with focus on their readiness to manage violence, serious events and disasters. Nurse Educ Pract. 2016;17:102-8 pubmed publisher
    ..compare self-reported disaster nursing competence (DNC) among nursing students (NSs) and among registered nurses (RNs) with professional experience...
  52. Saha S, Paul A, Herring L, Dutta A, Bhattacharya A, Samaddar S, et al. Gatekeeper Tyrosine Phosphorylation of SYMRK Is Essential for Synchronizing the Epidermal and Cortical Responses in Root Nodule Symbiosis. Plant Physiol. 2016;171:71-81 pubmed publisher
    Symbiosis receptor kinase (SYMRK) is indispensable for activation of root nodule symbiosis (RNS) at both epidermal and cortical levels and is functionally conserved in legumes...
  53. Sun X, Lacina K, Ramsamy E, Flower S, Fossey J, Qian X, et al. Reaction-based Indicator displacement Assay (RIA) for the selective colorimetric and fluorometric detection of peroxynitrite. Chem Sci. 2015;6:2963-2967 pubmed publisher
    ..system with a high binding affinity can preferably react with peroxynitrite over hydrogen peroxide and other ROS/RNS due to the protection of the boron via the solvent-insertion B-N interaction...
  54. Hanson S, MacLeod M, Schiller C. 'It's complicated': Staff nurse perceptions of their influence on nursing students' learning. A qualitative descriptive study. Nurse Educ Today. 2018;63:76-80 pubmed publisher
    ..their contributions to nursing students' learning during teacher-led practica? Nine staff Registered Nurses (RNs) working within a regional acute care hospital in western Canada were interviewed using semi-structured interviews...
  55. Gibson A, Woodman S, Pennelegion C, Patterson R, Stuart E, Hosker N, et al. Differential macrophage function in Brown Swiss and Holstein Friesian cattle. Vet Immunol Immunopathol. 2016;181:15-23 pubmed publisher
    ..The oxygen-dependent mechanisms rely on the generation of reactive oxygen and nitrogen species (ROS/RNS, respectively)...
  56. Lindley L, Held M, Henley K, Miller K, Pedziwol K, Rumley L. Nursing Unit Environment Associated with Provision of Language Services in Pediatric Hospices. J Racial Ethn Health Disparities. 2017;4:252-258 pubmed publisher
    ..Hospices with more specialized RNs and a stronger safety climate might include staffs who are dedicated to best care provision, including language ..
  57. Ramachandran J, Peluffo R. Threshold levels of extracellular l-arginine that trigger NOS-mediated ROS/RNS production in cardiac ventricular myocytes. Am J Physiol Cell Physiol. 2017;312:C144-C154 pubmed publisher
    ..O2?-), combined with NO, may lead to the production of the reactive nitrogen species (RNS) peroxynitrite (ONOO-), which is recognized as a major contributor to myocardial depression...
  58. Fairchild E, Roberts L, Zelman K, Michelli S, Hastings Tolsma M. Implementation of Robert's Coping with Labor Algorithm© in a large tertiary care facility. Midwifery. 2017;50:208-218 pubmed publisher
    ..a majority of RNs held a positive attitude toward use of the CWLA to assess laboring women's coping with the pain of labor as ..
  59. da Silva C, Silva M, Reis F, Ruiz A, de Carvalho J, Santos J, et al. Studies on free radical scavenging, cancer cell antiproliferation, and calf thymus DNA interaction of Schiff bases. J Photochem Photobiol B. 2017;172:129-138 pubmed publisher
    ..Their reactive nitrogen species (RNS) scavenging activity and inhibitory effects against cancer cell growth were then subsequently investigated...
  60. Asmaa Q, Al Shamerii S, Al Tag M, Al Shamerii A, Li Y, Osman B. Parasitological and biochemical studies on cutaneous leishmaniasis in Shara'b District, Taiz, Yemen. Ann Clin Microbiol Antimicrob. 2017;16:47 pubmed publisher
    ..001) in CL patients was obtained. The highest level of MDA may be due to over production of ROS and RNS results in oxidative stress and the acceleration of lipid peroxidation in CL patients...
  61. Mitchell D, Biro P. Is behavioural plasticity consistent across different environmental gradients and through time?. Proc Biol Sci. 2017;284: pubmed publisher
    ..Another important and related question is whether RNs are themselves consistently expressed through time or whether they are simply state dependent...
  62. Lemonde M, Payman N. Perceived roles of oncology nursing. Can Oncol Nurs J. 2015;25:422-42 pubmed
    ..Six focus groups were conducted and 21 registered nurses (RNs) from a community-based hospital participated in this study...
  63. Taylor E, Mamier I, Ricci Allegra P, Foith J. Self-reported frequency of nurse-provided spiritual care. Appl Nurs Res. 2017;35:30-35 pubmed publisher
    To describe how frequently RNs provide 17 spiritual care therapeutics (or interventions) during a 72-80h timeframe...
  64. Aryal S, Bisht G. New Paradigm for a Targeted Cancer Therapeutic Approach: A Short Review on Potential Synergy of Gold Nanoparticles and Cold Atmospheric Plasma. Biomedicines. 2017;5: pubmed publisher
    ..plasma, with rich reactive species including reactive oxygen species (ROS) and reactive nitrogen species (RNS), is being explored to selectively target and kill cancer cells, making them a promising anticancer agent...
  65. Park E, Kim Y, Park C. [A Comparison of Hospice Care Research Topics between Korea and Other Countries Using Text Network Analysis]. J Korean Acad Nurs. 2017;47:600-612 pubmed publisher
    ..Between Korean and international studies, six of the most important core keywords-"hospice," "patient," "death," "RNs," "care," and "family"-were common, whereas "cancer" from Korean studies and "palliative care" from international ..
  66. Nielsen A, Lasater K, Stock M. A framework to support preceptors' evaluation and development of new nurses' clinical judgment. Nurse Educ Pract. 2016;19:84-90 pubmed publisher
    ..are charged with bridging the gap between new graduates' learning in school and their autonomous practice as RNs. In one large, urban medical center in the U.S...
  67. Punaro G, Lima D, Rodrigues A, Pugliero S, Mouro M, Rogero M, et al. Cupuaçu extract reduces nitrosative stress and modulates inflammatory mediators in the kidneys of experimental diabetes. Clin Nutr. 2019;38:364-371 pubmed publisher
    ..for analysis of viability, proliferation, nitric oxide (NO) levels and reactive oxygen species or nitrogen (ROS/RNS)...
  68. Gardulf A, Nilsson J, Florin J, Leksell J, Lepp M, Lindholm C, et al. The Nurse Professional Competence (NPC) Scale: Self-reported competence among nursing students on the point of graduation. Nurse Educ Today. 2016;36:165-71 pubmed publisher
    ..Low competence among RNs has been shown to increase the morbidity and mortality of inpatients...
  69. Smeds Alenius L, Tishelman C, Lindqvist R, Runesdotter S, McHugh M. RN assessments of excellent quality of care and patient safety are associated with significantly lower odds of 30-day inpatient mortality: A national cross-sectional study of acute-care hospitals. Int J Nurs Stud. 2016;61:117-24 pubmed publisher
    ..One underutilized resource worthy of further exploration is the use of registered nurses (RNs) as informants of overall quality of care and patient safety...
  70. Bombelli F, Lispi L, Porrini S, Giacanelli M, Terracciano C, Massa R, et al. Neuromuscular transmission abnormalities in myotonic dystrophy type 1: A neurophysiological study. Clin Neurol Neurosurg. 2016;150:84-88 pubmed publisher
    ..In order to substantiate this hypothesis we performed low rate repetitive nerve stimulation (RNS) and single fiber electromyography (SFEMG), in 14 DM1 subjects...
  71. Pflüger P, Viau C, Coelho V, Berwig N, Staub R, Pereira P, et al. Gamma-decanolactone inhibits iNOS and TNF-alpha production by lipopolysaccharide-activated microglia in N9 cells. Eur J Pharmacol. 2016;780:38-45 pubmed publisher
    Activated microglia that produce reactive nitrogen species (RNS), inflammatory factors, reactive oxygen species (ROS), and other neurovirulent factors may lead to the development of neurodegenerative diseases...
  72. Pal R, Chakraborty B, Nath A, Singh L, Ali M, Rahman D, et al. Noble metal nanoparticle-induced oxidative stress modulates tumor associated macrophages (TAMs) from an M2 to M1 phenotype: An in vitro approach. Int Immunopharmacol. 2016;38:332-41 pubmed publisher
    ..it has been seen that AuNPs and AgNPs modulate the reactive oxygen species (ROS) and reactive nitrogen species (RNS) production, suppressing the antioxidant system of cells (TAMs)...
  73. Wilkie A, Byren J, Hurst J, Jayamohan J, Johnson D, Knight S, et al. Prevalence and complications of single-gene and chromosomal disorders in craniosynostosis. Pediatrics. 2010;126:e391-400 pubmed publisher
  74. Cowperthwaite L, Fearon M. Guideline Implementation: Minimally Invasive Surgery, Part 2-Hybrid ORs. AORN J. 2017;106:145-153 pubmed publisher
    ..Perioperative RNs should review the complete guideline for additional information and for guidance when writing and updating policies ..
  75. Fencl J, Matthews C. Translating Evidence Into Practice: How Advanced Practice RNs Can Guide Nurses in Challenging Established Practice to Arrive at Best Practice. AORN J. 2017;106:378-392 pubmed publisher
    ..Perioperative APRNs play an important role as evidence-based practice experts to assist with translating research and evidence into clinical practice for safe, quality care in the perioperative setting. ..
  76. Zhu X, Chen J, Ma C, Liu X, Cao X, Zhang H. A ratiometric mitochondria-targeting two-photon fluorescent probe for imaging of nitric oxide in vivo. Analyst. 2017;142:4623-4628 pubmed publisher
    ..Mito-N exhibited excellent selectivity and sensitivity toward NO among various ROS/RNS. The successful two-photon imaging of mitochondrial NO proved that Mito-N is a powerful noninvasive imaging tool in ..
  77. M Aghajan Z, Schuette P, Fields T, Tran M, Siddiqui S, Hasulak N, et al. Theta Oscillations in the Human Medial Temporal Lobe during Real-World Ambulatory Movement. Curr Biol. 2017;27:3743-3751.e3 pubmed publisher
    ..activity from participants chronically implanted with the wireless NeuroPace responsive neurostimulator (RNS) and tracked their motion with sub-millimeter precision...
  78. Carasa M, Nespoli G. Nursing the chronically critically ill patient. Crit Care Clin. 2002;18:493-507 pubmed
    ..For example, in environments without NPs, trained RNs can collaborate with dedicated physicians to coordinate patients' care [1-3,8]...
  79. Adhikary R, Sultana S, Bishayi B. Clitoria ternatea flower petals: Effect on TNFR1 neutralization via downregulation of synovial matrix metalloproteases. J Ethnopharmacol. 2018;210:209-222 pubmed publisher
    ..in release of pro-inflammatory cytokines, chemokines, reactive oxygen species (ROS)/ reactive nitrogen species (RNS) production in parallel to significant (p<0.05) reduction in TNFR1, TLR2, iNOS, COX-2 and MMP-2 expression...
  80. Guanghe Zhang -, Samuel O, Fanghua Liu -, Shixiong Chen -, Hui Zhou -, Haoshi Zhang -, et al. Electromyogram-based method to secure wireless body sensor networks for rehabilitation systems. Conf Proc IEEE Eng Med Biol Soc. 2017;2017:1246-1249 pubmed publisher
    ..Conventionally, the random numbers (RNs) based on the inter-pulse intervals (IPIs) from electrocardiogram (ECG) recordings have been widely used to secure ..
  81. Pietrofesa R, Woodruff P, Hwang W, Patel P, Chatterjee S, Albelda S, et al. The Synthetic Lignan Secoisolariciresinol Diglucoside Prevents Asbestos-Induced NLRP3 Inflammasome Activation in Murine Macrophages. Oxid Med Cell Longev. 2017;2017:7395238 pubmed publisher
    ..that are linked to malignancy: (1) the generation of reactive oxygen species (ROS)/reactive nitrogen species (RNS) and (2) the activation of an inflammation cascade that drives acute and chronic inflammation, with the NLRP3 ..
  82. Tu Y, Lin Y, Lee J, Fan L. Effects of Didactic Instruction and Test-Enhanced Learning in a Nursing Review Course. J Nurs Educ. 2017;56:683-687 pubmed publisher
    Determining the most effective approach for students' successful academic performance and achievement on the national licensure examination for RNs is important to nursing education and practice.
  83. Truong V, Jun M, Jeong W. Role of resveratrol in regulation of cellular defense systems against oxidative stress. Biofactors. 2017;: pubmed publisher
    ..through its ability of either directly neutralizing reactive oxygen species/reactive nitrogen species (ROS/RNS) or indirectly upregulating the expression of cellular defensive genes...
  84. McFarland D, Doucette J. Impact of High-Reliability Education on Adverse Event Reporting by Registered Nurses. J Nurs Care Qual. 2017;: pubmed publisher
    ..risks and improve patient safety, but, historically, adverse events are underreported by registered nurses (RNs) because of fear of retribution and blame...
  85. Hardy M, Zielonka J, Karoui H, Sikora A, Michalski R, Podsiadły R, et al. Detection and Characterization of Reactive Oxygen and Nitrogen Species in Biological Systems by Monitoring Species-Specific Products. Antioxid Redox Signal. 2017;: pubmed publisher
    ..Despite the significance of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in numerous diseases and intracellular signaling, the rigorous detection of ROS and RNS has remained a challenge...
  86. Deweirdt J, Quignard J, Crobeddu B, Baeza Squiban A, Sciare J, Courtois A, et al. Involvement of oxidative stress and calcium signaling in airborne particulate matter - induced damages in human pulmonary artery endothelial cells. Toxicol In Vitro. 2017;45:340-350 pubmed publisher
    ..by electronic paramagnetic resonance spectroscopy and MitoSOX probe, (iii) reactive nitrosative species (RNS) production by Griess reaction, and (vi) calcium signaling by the Fluo-4 probe. In acellular conditions, PM2...
  87. Zhang P, Wang H, Hong Y, Yu M, Zeng R, Long Y, et al. Selective visualization of endogenous hypochlorous acid in zebrafish during lipopolysaccharide-induced acute liver injury using a polymer micelles-based ratiometric fluorescent probe. Biosens Bioelectron. 2018;99:318-324 pubmed publisher
    ..75nM), and outstanding selectivity toward HClO over other ROS/RNS (50 equiv.)...
  88. Chaudhary S, Parvez S. Phytanic acid induced neurological alterations in rat brain synaptosomes and its attenuation by melatonin. Biomed Pharmacother. 2017;95:37-46 pubmed publisher
    ..effects on cellular stress, by reducing reactive oxygen species (ROS) and reactive nitrogen species (RNS)...
  89. Bauer G. Autoamplificatory singlet oxygen generation sensitizes tumor cells for intercellular apoptosis-inducing signaling. Mech Ageing Dev. 2018;172:59-77 pubmed publisher
    ..oxidase-1 (NOX1) in their membrane and control NOX1-based intercellular reactive oxygen and nitrogen species (ROS/RNS)-dependent apoptosis-inducing signaling through membrane-associated catalase and superoxide dismutase...
  90. Royes L, Gabbi P, Ribeiro L, Della Pace I, Rodrigues F, de Oliveira Ferreira A, et al. A neuronal disruption in redox homeostasis elicited by ammonia alters the glycine/glutamate (GABA) cycle and contributes to MMA-induced excitability. Amino Acids. 2016;48:1373-89 pubmed publisher
    ..On the basis of our findings, the changes in ROS and reactive nitrogen species (RNS) levels elicited by ammonia alter the glycine/glutamate (GABA) cycle and contribute to MMA-induced excitability.
  91. Chen Z, Zhang S, Levchenko I, Beilis I, Keidar M. In vitro Demonstration of Cancer Inhibiting Properties from Stratified Self-Organized Plasma-Liquid Interface. Sci Rep. 2017;7:12163 pubmed publisher
    ..Furthermore, thinly stratified, self-organized interfacial discharge is capable to efficiently control the ROS and RNS concentrations in the cancer-inhibiting media...
  92. Sturesson L, Falk A, Ulfvarson J, Lindstrom V. Registered Nurses' own experience of using a nurse-initiated pain protocol based on their working experience. J Clin Nurs. 2017;: pubmed publisher
    ..The aim of the study was to explore registered nurses' (RN) own experience of using the nurse-initiated pain protocol (NIPP) in the emergency department (ED) based on their working experience...