FAK

Summary

Gene Symbol: FAK
Description: protein tyrosine kinase 2
Alias: FADK, FAK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK, focal adhesion kinase 1, FADK 1, FAK-related non-kinase polypeptide, PTK2 protein tyrosine kinase 2, focal adhesion kinase isoform FAK-Del33, focal adhesion kinase-related nonkinase, protein phosphatase 1 regulatory subunit 71
Species: human
Products:     FAK

Top Publications

  1. Fujita H, Kamiguchi K, Cho D, Shibanuma M, Morimoto C, Tachibana K. Interaction of Hic-5, A senescence-related protein, with focal adhesion kinase. J Biol Chem. 1998;273:26516-21 pubmed
    ..Here we show that Hic-5 binds to focal adhesion kinase (FAK) by its N-terminal domain, and is localized to focal adhesions by its C-terminal LIM domains...
  2. Golubovskaya V, Gross S, Kaur A, Wilson R, Xu L, Yang X, et al. Simultaneous inhibition of focal adhesion kinase and SRC enhances detachment and apoptosis in colon cancer cell lines. Mol Cancer Res. 2003;1:755-64 pubmed
    Focal adhesion kinase (FAK) and Src have been shown to be overexpressed in colon cancer. We have studied the role of these two kinases in resistance to apoptosis...
  3. Demers M, Thibodeau S, Noël D, Fujita N, Tsuruo T, Gauthier R, et al. Intestinal epithelial cancer cell anoikis resistance: EGFR-mediated sustained activation of Src overrides Fak-dependent signaling to MEK/Erk and/or PI3-K/Akt-1. J Cell Biochem. 2009;107:639-54 pubmed publisher
    Herein, we investigated the survival roles of Fak, Src, MEK/Erk, and PI3-K/Akt-1 in intestinal epithelial cancer cells (HCT116, HT29, and T84), in comparison to undifferentiated and differentiated intestinal epithelial cells (IECs)...
  4. Le Boeuf F, Houle F, Sussman M, Huot J. Phosphorylation of focal adhesion kinase (FAK) on Ser732 is induced by rho-dependent kinase and is essential for proline-rich tyrosine kinase-2-mediated phosphorylation of FAK on Tyr407 in response to vascular endothelial growth factor. Mol Biol Cell. 2006;17:3508-20 pubmed
    Focal adhesion kinase (FAK) is phosphorylated on tyrosine and serine residues after cell activation...
  5. Tomar A, Schlaepfer D. Focal adhesion kinase: switching between GAPs and GEFs in the regulation of cell motility. Curr Opin Cell Biol. 2009;21:676-83 pubmed publisher
    Focal adhesion (FA) kinase (FAK) is a cytoplasmic protein-tyrosine kinase involved in cytoskeleton remodeling, formation and disassembly of cell adhesion structures, and in the regulation of Rho-family GTPases...
  6. Xu M, Bower K, Chen G, Shi X, Dong Z, Ke Z, et al. Ethanol enhances the interaction of breast cancer cells over-expressing ErbB2 with fibronectin. Alcohol Clin Exp Res. 2010;34:751-60 pubmed publisher
    ..Ethanol induced phosphorylation of ErbB2 at Tyr1248, FAK at Tyr861, and cSrc at Try216...
  7. Deng B, Yang X, Liu J, He F, Zhu Z, Zhang C. Focal adhesion kinase mediates TGF-beta1-induced renal tubular epithelial-to-mesenchymal transition in vitro. Mol Cell Biochem. 2010;340:21-9 pubmed publisher
    Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase which participates in many important cellular processes such as cell adhesion and migration...
  8. Guessous F, Yang Y, Johnson E, Marcinkiewicz L, Smith M, Zhang Y, et al. Cooperation between c-Met and focal adhesion kinase family members in medulloblastoma and implications for therapy. Mol Cancer Ther. 2012;11:288-97 pubmed publisher
    ..The nonreceptor tyrosine kinases focal adhesion kinase (FAK) and Pyk2 are key players in the progression of different cancers...
  9. Theocharis S, Klijanienko J, Padoy E, Athanassiou S, Sastre Garau X. Focal adhesion kinase (FAK) immunocytochemical expression in breast ductal invasive carcinoma (DIC): correlation with clinicopathological parameters and tumor proliferative capacity. Med Sci Monit. 2009;15:BR221-6 pubmed
    Focal adhesion kinase (FAK) is an enzyme of the tyrosine kinase group linked to signaling pathways between cells and the extracellular matrix...

More Information

Publications82

  1. Beierle E, Massoll N, Hartwich J, Kurenova E, Golubovskaya V, Cance W, et al. Focal adhesion kinase expression in human neuroblastoma: immunohistochemical and real-time PCR analyses. Clin Cancer Res. 2008;14:3299-305 pubmed publisher
    The focal adhesion kinase (FAK) is a nonreceptor protein tyrosine kinase important in signaling between cells and their extracellular matrix...
  2. Morales S, Mareninov S, Coulam P, Wadehra M, Goodglick L, Braun J, et al. Functional consequences of interactions between FAK and epithelial membrane protein 2 (EMP2). Invest Ophthalmol Vis Sci. 2009;50:4949-56 pubmed publisher
    ..gel contraction by ARPE-19 is controlled by epithelial membrane protein 2 (EMP2) through focal adhesion kinase (FAK) activation. The purpose of this study was to test the role of EMP2 in the cellular context of FAK activation...
  3. Ji H, Pang D, Fu S, Jin Y, Yao L, Qi J, et al. Overexpression of focal adhesion kinase correlates with increased lymph node metastasis and poor prognosis in non-small-cell lung cancer. J Cancer Res Clin Oncol. 2013;139:429-35 pubmed publisher
    The aim of this study was to investigate whether focal adhesion kinase (FAK) overexpression correlates with lymph node metastases and prognosis...
  4. Ko B, Jan Y, Chang T, Liang S, Chen S, Liu T, et al. Upregulation of focal adhesion kinase by 14-3-3? via NF?B activation in hepatocellular carcinoma. Anticancer Agents Med Chem. 2013;13:555-62 pubmed
    Focal adhesion kinase (FAK) is implicated in cancer cell survival, proliferation and migration...
  5. Vitale S, Avizienyte E, Brunton V, Frame M. Focal adhesion kinase is not required for Src-induced formation of invadopodia in KM12C colon cancer cells and can interfere with their assembly. Eur J Cell Biol. 2008;87:569-79 pubmed publisher
    ..b>FAK is present with active Src at sites of matrix-degrading activity (invadopodia), specifically residing in rings ..
  6. Chan K, Cortesio C, Huttenlocher A. FAK alters invadopodia and focal adhesion composition and dynamics to regulate breast cancer invasion. J Cell Biol. 2009;185:357-70 pubmed publisher
    Focal adhesion kinase (FAK) is important for breast cancer progression and invasion and is necessary for the dynamic turnover of focal adhesions...
  7. Aponte M, Jiang W, Lakkis M, Li M, Edwards D, Albitar L, et al. Activation of platelet-activating factor receptor and pleiotropic effects on tyrosine phospho-EGFR/Src/FAK/paxillin in ovarian cancer. Cancer Res. 2008;68:5839-48 pubmed publisher
    ..Using quantitative multiplex phospho-antibody array technology, we found that tyrosine phosphorylation of EGFR/Src/FAK/paxillin was coordinately activated by PAF treatment, which was correlated with the activation of ..
  8. Golubovskaya V, Figel S, Ho B, Johnson C, Yemma M, Huang G, et al. A small molecule focal adhesion kinase (FAK) inhibitor, targeting Y397 site: 1-(2-hydroxyethyl)-3, 5, 7-triaza-1-azoniatricyclo [3.3.1.1(3,7)]decane; bromide effectively inhibits FAK autophosphorylation activity and decreases cancer cell viability, c. Carcinogenesis. 2012;33:1004-13 pubmed publisher
    Focal adhesion kinase (FAK) is a protein tyrosine kinase that is overexpressed in most solid types of tumors and plays an important role in the survival signaling...
  9. Beierle E, Ma X, Stewart J, Nyberg C, Trujillo A, Cance W, et al. Inhibition of focal adhesion kinase decreases tumor growth in human neuroblastoma. Cell Cycle. 2010;9:1005-15 pubmed
    Neuroblastoma is the most common extracranial solid tumor of childhood. Focal adhesion kinase (FAK) is an intracellular kinase that regulates both cellular adhesion and apoptosis...
  10. Bouchard V, Harnois C, Demers M, Thibodeau S, Laquerre V, Gauthier R, et al. B1 integrin/Fak/Src signaling in intestinal epithelial crypt cell survival: integration of complex regulatory mechanisms. Apoptosis. 2008;13:531-42 pubmed publisher
    ..To this effect, the roles of beta1 integrin/Fak/Src signaling to the PI3-K/Akt-1, MEK/Erk, and p38 pathways, were investigated...
  11. Bai X, Zhang W, Liu N, Jiang H, Lou K, Peng T, et al. Focal adhesion kinase: important to prostaglandin E2-mediated adhesion, migration and invasion in hepatocellular carcinoma cells. Oncol Rep. 2009;21:129-36 pubmed
    ..In addition, the effects of PGE2 were found to be associated with focal adhesion kinase (FAK). PGE2 treatment increased the phosphorylation and synthesis of FAK in a dose-dependent manner...
  12. Sood A, Armaiz Pena G, Halder J, Nick A, Stone R, Hu W, et al. Adrenergic modulation of focal adhesion kinase protects human ovarian cancer cells from anoikis. J Clin Invest. 2010;120:1515-23 pubmed publisher
    ..epinephrine protected the tumor cells from anoikis and promoted their growth by activating focal adhesion kinase (FAK)...
  13. Yuan Z, Zheng Q, Fan J, Ai K, Chen J, Huang X. Expression and prognostic significance of focal adhesion kinase in hepatocellular carcinoma. J Cancer Res Clin Oncol. 2010;136:1489-96 pubmed publisher
    To examine the expressions of focal adhesion kinase (FAK) and its clinical significance in hepatocellular carcinoma (HCC)...
  14. Chen T, Chan P, Chen C, Chen H. Phosphorylation of focal adhesion kinase on tyrosine 194 by Met leads to its activation through relief of autoinhibition. Oncogene. 2011;30:153-66 pubmed publisher
    Focal adhesion kinase (FAK) has a crucial role in integration of signals from integrins and growth factor receptors...
  15. Sanchez A, Flamini M, Baldacci C, Goglia L, Genazzani A, Simoncini T. Estrogen receptor-alpha promotes breast cancer cell motility and invasion via focal adhesion kinase and N-WASP. Mol Endocrinol. 2010;24:2114-25 pubmed publisher
    ..of the cytoskeleton and cell membrane and is controlled by multiprotein complexes including focal adhesion kinase (FAK) or the Neural Wiskott-Aldrich Syndrome Protein (N-WASP)...
  16. Frame M, Patel H, Serrels B, Lietha D, Eck M. The FERM domain: organizing the structure and function of FAK. Nat Rev Mol Cell Biol. 2010;11:802-14 pubmed publisher
    Focal adhesion kinase (FAK) is a scaffold and tyrosine kinase protein that binds to itself and cellular partners through its four-point-one, ezrin, radixin, moesin (FERM) domain...
  17. Ward K, Tancioni I, Lawson C, Miller N, Jean C, Chen X, et al. Inhibition of focal adhesion kinase (FAK) activity prevents anchorage-independent ovarian carcinoma cell growth and tumor progression. Clin Exp Metastasis. 2013;30:579-94 pubmed publisher
    ..Focal adhesion kinase (FAK) is a cytoplasmic protein-tyrosine kinase located on chromosome 8q24...
  18. Wang X, Urvalek A, Liu J, Zhao J. Activation of KLF8 transcription by focal adhesion kinase in human ovarian epithelial and cancer cells. J Biol Chem. 2008;283:13934-42 pubmed publisher
    KLF8 (Krüppel-like factor 8) is a transcription factor downstream of focal adhesion kinase (FAK) important in the regulation of the cell cycle and also plays a critical role in oncogenic transformation and epithelial to mesenchymal ..
  19. Jiang H, Liu L, Ye J, Liu H, Xing S, Wu Y. Focal adhesion kinase serves as a marker of cervical lymph node metastasis and is a potential therapeutic target in tongue cancer. J Cancer Res Clin Oncol. 2010;136:1295-302 pubmed publisher
    The aims of the present study were to examine whether focal adhesion kinase (FAK) expression is correlated with cervical lymph node metastasis of tongue cancer and to investigate the roles of FAK in the process of cancer cell migration, ..
  20. Chan K, Bennin D, Huttenlocher A. Regulation of adhesion dynamics by calpain-mediated proteolysis of focal adhesion kinase (FAK). J Biol Chem. 2010;285:11418-26 pubmed publisher
    ..regions after Ser-745, resulting in a C-terminal fragment similar in size to the FAK-related non-kinase (FRNK)...
  21. Lim S, Chen X, Lim Y, Hanson D, Vo T, Howerton K, et al. Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation. Mol Cell. 2008;29:9-22 pubmed publisher
    b>FAK is known as an integrin- and growth factor-associated tyrosine kinase promoting cell motility. Here we show that, during mouse development, FAK inactivation results in p53- and p21-dependent mesodermal cell growth arrest...
  22. Ossovskaya V, Lim S, Ota N, Schlaepfer D, Ilic D. FAK nuclear export signal sequences. FEBS Lett. 2008;582:2402-6 pubmed publisher
    Ubiquitously expressed focal adhesion kinase (FAK), a critical component in transducing signals from sites of cell contacts with extracellular matrix, was named after its typical localization in focal adhesions...
  23. Behmoaram E, Bijian K, Jie S, Xu Y, Darnel A, Bismar T, et al. Focal adhesion kinase-related proline-rich tyrosine kinase 2 and focal adhesion kinase are co-overexpressed in early-stage and invasive ErbB-2-positive breast cancer and cooperate for breast cancer cell tumorigenesis and invasiveness. Am J Pathol. 2008;173:1540-50 pubmed publisher
    ..Key regulators include the focal adhesion kinase (FAK) and FAK-related proline-rich tyrosine kinase 2 (Pyk2), whose distinct functions in cancer progression remain ..
  24. Fu X, Goglia L, Sanchez A, Flamini M, Giretti M, Tosi V, et al. Progesterone receptor enhances breast cancer cell motility and invasion via extranuclear activation of focal adhesion kinase. Endocr Relat Cancer. 2010;17:431-43 pubmed publisher
    ..In T47-D breast cancer cells, progesterone rapidly enhances FA kinase (FAK) phosphorylation at Tyr(397) in a time- and concentration-dependent manner...
  25. Li C, Zhang X, Cheng L, Dai L, Xu F, Zhang J, et al. RNA interference targeting human FAK and EGFR suppresses human non-small-cell lung cancer xenograft growth in nude mice. Cancer Gene Ther. 2013;20:101-8 pubmed publisher
    Transfection of plasmid vectors coexpressing short hairpin RNA (shRNA) for focal adhesion kinase (FAK) and epidermal growth factor receptor (EGFR) significantly inhibited protein level of FAK and EGFR...
  26. Infante J, Camidge D, Mileshkin L, Chen E, Hicks R, Rischin D, et al. Safety, pharmacokinetic, and pharmacodynamic phase I dose-escalation trial of PF-00562271, an inhibitor of focal adhesion kinase, in advanced solid tumors. J Clin Oncol. 2012;30:1527-33 pubmed publisher
    PF-00562271 is a novel inhibitor of focal adhesion kinase (FAK)...
  27. Ucar D, Kurenova E, Garrett T, Cance W, Nyberg C, Cox A, et al. Disruption of the protein interaction between FAK and IGF-1R inhibits melanoma tumor growth. Cell Cycle. 2012;11:3250-9 pubmed publisher
    b>FAK (focal adhesion kinase) and IGF-1R (insulin-like growth factor receptor-1) directly interact with each other and thereby activate crucial signaling pathways that benefit cancer cells...
  28. Ding L, Sun X, You Y, Liu N, Fu Z. Expression of focal adhesion kinase and phosphorylated focal adhesion kinase in human gliomas is associated with unfavorable overall survival. Transl Res. 2010;156:45-52 pubmed publisher
    Human glioma is a malignancy that has no effective systemic therapy. Focal adhesion kinase (FAK) is overexpressed in various invasive and metastatic tumor cells...
  29. Eke I, Deuse Y, Hehlgans S, Gurtner K, Krause M, Baumann M, et al. ??Integrin/FAK/cortactin signaling is essential for human head and neck cancer resistance to radiotherapy. J Clin Invest. 2012;122:1529-40 pubmed publisher
    ..Mechanistically, dephosphorylation of focal adhesion kinase (FAK) upon inhibition of ?? integrin resulted in dissociation of a FAK/cortactin protein complex...
  30. Kurio N, Shimo T, Fukazawa T, Takaoka M, Okui T, Hassan N, et al. Anti-tumor effect in human breast cancer by TAE226, a dual inhibitor for FAK and IGF-IR in vitro and in vivo. Exp Cell Res. 2011;317:1134-46 pubmed publisher
    Focal adhesion kinase (FAK) is a 125-kDa non-receptor type tyrosine kinase that localizes to focal adhesions...
  31. Plaza Menacho I, Morandi A, Mologni L, Boender P, Gambacorti Passerini C, Magee A, et al. Focal adhesion kinase (FAK) binds RET kinase via its FERM domain, priming a direct and reciprocal RET-FAK transactivation mechanism. J Biol Chem. 2011;286:17292-302 pubmed publisher
    ..The identification of focal adhesion kinase (FAK) as a direct substrate for RET kinase revealed (i) a RET-FAK transactivation mechanism consisting of direct ..
  32. Holinstat M, Knezevic N, Broman M, Samarel A, Malik A, Mehta D. Suppression of RhoA activity by focal adhesion kinase-induced activation of p190RhoGAP: role in regulation of endothelial permeability. J Biol Chem. 2006;281:2296-305 pubmed
    ..Inhibition of FAK by adenoviral expression of FRNK (a dominant negative FAK construct) in monolayers prevented p190RhoGAP phosphorylation, increased RhoA activity, ..
  33. Wen L, Fahrni J, Troie S, Guan J, Orth K, Rosen G. Cleavage of focal adhesion kinase by caspases during apoptosis. J Biol Chem. 1997;272:26056-61 pubmed
    ..The interactions of integrins with the extracellular matrix activates focal adhesion kinase (FAK) and suppresses apoptosis in diverse cell types...
  34. Jiang X, Sinnett Smith J, Rozengurt E. Differential FAK phosphorylation at Ser-910, Ser-843 and Tyr-397 induced by angiotensin II, LPA and EGF in intestinal epithelial cells. Cell Signal. 2007;19:1000-10 pubmed
    A rapid increase in the tyrosine phosphorylation of the non-receptor tyrosine kinase FAK is a prominent early event in fibroblasts stimulated by a variety of signaling molecules...
  35. Retta S, Barry S, Critchley D, Defilippi P, Silengo L, Tarone G. Focal adhesion and stress fiber formation is regulated by tyrosine phosphatase activity. Exp Cell Res. 1996;229:307-17 pubmed
    ..In the present study we examined the role of tyrosine phosphatases in this process using p125FAK and paxillin as substrates...
  36. Schaller M. Biochemical signals and biological responses elicited by the focal adhesion kinase. Biochim Biophys Acta. 2001;1540:1-21 pubmed
    The focal adhesion kinase, FAK, is an important component of an integrin-dependent signaling pathway, which functions to transmit signals from the extracellular matrix into the cytoplasm...
  37. Liang F, Qi R, Chang C. Signalling of GPI-anchored CD157 via focal adhesion kinase in MCA102 fibroblasts. FEBS Lett. 2001;506:207-10 pubmed
    ..In this study, we have identified the p130 protein to be focal adhesion kinase (FAK or pp125(FAK))...
  38. Brown M, Perrotta J, Turner C. Serine and threonine phosphorylation of the paxillin LIM domains regulates paxillin focal adhesion localization and cell adhesion to fibronectin. Mol Biol Cell. 1998;9:1803-16 pubmed
    ..Additionally, these results provide the first evidence that paxillin contributes to "inside-out" integrin-mediated signal transduction. ..
  39. Hecker T, Ding Q, Rege T, Hanks S, Gladson C. Overexpression of FAK promotes Ras activity through the formation of a FAK/p120RasGAP complex in malignant astrocytoma cells. Oncogene. 2004;23:3962-71 pubmed
    Focal adhesion kinase (FAK) signaling may be mediated through the modulation of Ras activity...
  40. Messina S, Onofri F, Bongiorno Borbone L, Giovedi S, Valtorta F, Girault J, et al. Specific interactions of neuronal focal adhesion kinase isoforms with Src kinases and amphiphysin. J Neurochem. 2003;84:253-65 pubmed
    Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that activates Src family kinases via SH2- and SH3-mediated interactions...
  41. Calalb M, Zhang X, Polte T, Hanks S. Focal adhesion kinase tyrosine-861 is a major site of phosphorylation by Src. Biochem Biophys Res Commun. 1996;228:662-8 pubmed
    Focal adhesion kinase (FAK) participates in signaling events induced by diverse stimuli including integrin engagement, oncogenic transformation and mitogenic neuropeptides...
  42. Hanks S, Ryzhova L, Shin N, Brabek J. Focal adhesion kinase signaling activities and their implications in the control of cell survival and motility. Front Biosci. 2003;8:d982-96 pubmed
    Focal adhesion kinase (FAK) was first described in 1992 as a novel nonreceptor protein-tyrosine kinase localized prominently within focal adhesions, suggesting a signaling role in regulating cell behavior resulting from integrin ..
  43. Bouchard V, Demers M, Thibodeau S, Laquerre V, Fujita N, Tsuruo T, et al. Fak/Src signaling in human intestinal epithelial cell survival and anoikis: differentiation state-specific uncoupling with the PI3-K/Akt-1 and MEK/Erk pathways. J Cell Physiol. 2007;212:717-28 pubmed
    ..In the present study, we analyzed the roles of focal adhesion kinase (Fak)/Src signaling to the PI3-K/Akt-1 and mitogen-activated protein kinase (MEK)/extracellular regulated kinases (Erk) ..
  44. Tachibana K, Sato T, D Avirro N, Morimoto C. Direct association of pp125FAK with paxillin, the focal adhesion-targeting mechanism of pp125FAK. J Exp Med. 1995;182:1089-99 pubmed
    Focal adhesion kinase (pp125FAK) is localized to focal adhesions and tyrosine phosphorylated by the engagement of beta 1 integrins. However, it is unclear how pp125FAK is linked to integrin molecules...
  45. Judson P, He X, Cance W, Van Le L. Overexpression of focal adhesion kinase, a protein tyrosine kinase, in ovarian carcinoma. Cancer. 1999;86:1551-6 pubmed
    Focal adhesion kinase (FAK) is a tyrosine kinase that is important to such key functions such as cell adhesion, motility, and invasion...
  46. Lu Z, Jiang G, Blume Jensen P, Hunter T. Epidermal growth factor-induced tumor cell invasion and metastasis initiated by dephosphorylation and downregulation of focal adhesion kinase. Mol Cell Biol. 2001;21:4016-31 pubmed
    ..cells that overexpress EGFR, EGF treatment induced rapid tyrosine dephosphorylation of focal adhesion kinase (FAK) associated with downregulation of its kinase activity...
  47. Beierle E, Trujillo A, Nagaram A, Kurenova E, Finch R, Ma X, et al. N-MYC regulates focal adhesion kinase expression in human neuroblastoma. J Biol Chem. 2007;282:12503-16 pubmed
    ..Focal adhesion kinase (FAK) is a survival factor that has been shown to be overexpressed in many types of human cancers...
  48. Schmitz K, Grabellus F, Callies R, Otterbach F, Wohlschlaeger J, Levkau B, et al. High expression of focal adhesion kinase (p125FAK) in node-negative breast cancer is related to overexpression of HER-2/neu and activated Akt kinase but does not predict outcome. Breast Cancer Res. 2005;7:R194-203 pubmed
    Focal adhesion kinase (FAK) regulates multiple cellular processes including growth, differentiation, adhesion, motility and apoptosis...
  49. Golubovskaya V, Kaur A, Cance W. Cloning and characterization of the promoter region of human focal adhesion kinase gene: nuclear factor kappa B and p53 binding sites. Biochim Biophys Acta. 2004;1678:111-25 pubmed
    Focal adhesion kinase (FAK) gene encodes focal adhesion kinase that localizes at contact points of cells with extracellular matrix...
  50. Kharbanda S, Saleem A, Yuan Z, Emoto Y, Prasad K, Kufe D. Stimulation of human monocytes with macrophage colony-stimulating factor induces a Grb2-mediated association of the focal adhesion kinase pp125FAK and dynamin. Proc Natl Acad Sci U S A. 1995;92:6132-6 pubmed
    ..monocytes, we show that M-CSF induces interaction of the Grb2 adaptor protein with the focal adhesion kinase pp125FAK. The results demonstrate that tyrosine-phosphorylated pp125FAK directly interacts with the SH2 domain of Grb2...
  51. Xing Z, Chen H, Nowlen J, Taylor S, Shalloway D, Guan J. Direct interaction of v-Src with the focal adhesion kinase mediated by the Src SH2 domain. Mol Biol Cell. 1994;5:413-21 pubmed
    The recently described focal adhesion kinase (FAK) has been implicated in signal transduction pathways initiated by cell adhesion receptor integrins and by neuropeptide growth factors...
  52. Minegishi M, Tachibana K, Sato T, Iwata S, Nojima Y, Morimoto C. Structure and function of Cas-L, a 105-kD Crk-associated substrate-related protein that is involved in beta 1 integrin-mediated signaling in lymphocytes. J Exp Med. 1996;184:1365-75 pubmed
    ..that pp105 contains conserved motifs with p130Cas, and both pp105 and p130Cas bind to focal adhesion kinase (pp125FAK) and Crk...
  53. Gabriel B, Mildenberger S, Weisser C, Metzger E, Gitsch G, Schüle R, et al. Focal adhesion kinase interacts with the transcriptional coactivator FHL2 and both are overexpressed in epithelial ovarian cancer. Anticancer Res. 2004;24:921-7 pubmed
    ..In our study we investigated the association of pp125FAK, a cytoplasmic tyrosine kinase, involved in anchorage-independent growth of tumor cells, and the Four and a Half ..
  54. Tachibana K, Urano T, Fujita H, Ohashi Y, Kamiguchi K, Iwata S, et al. Tyrosine phosphorylation of Crk-associated substrates by focal adhesion kinase. A putative mechanism for the integrin-mediated tyrosine phosphorylation of Crk-associated substrates. J Biol Chem. 1997;272:29083-90 pubmed
    ..binding induces the tyrosine phosphorylation of various proteins including focal adhesion kinase (pp125(FAK)) and Crk-associated substrate (Cas)...
  55. Gervais F, Thornberry N, Ruffolo S, Nicholson D, Roy S. Caspases cleave focal adhesion kinase during apoptosis to generate a FRNK-like polypeptide. J Biol Chem. 1998;273:17102-8 pubmed
    ..fragments that are generated suppress phosphorylation of endogenous Fak and thus resemble a natural variant of Fak, FRNK, that inhibits Fak activity by preventing the localization of Fak to focal adhesions...
  56. Gabarra Niecko V, Schaller M, Dunty J. FAK regulates biological processes important for the pathogenesis of cancer. Cancer Metastasis Rev. 2003;22:359-74 pubmed
    ..initial discovery as a substrate and binding partner for the Src oncogene, a role for the focal adhesion kinase (FAK) in cancer has been speculated...
  57. Satoh T, Surmacz T, Nyormoi O, Whitacre C. Inhibition of focal adhesion kinase by antisense oligonucleotides enhances the sensitivity of breast cancer cells to camptothecins. Biocell. 2003;27:47-55 pubmed
    ..Because p125 focal adhesion kinase (FAK) is a transducer in the beta 1-integrin signaling pathway, it is essential to cell adhesion and it is overexpressed ..
  58. Okabe S, Fukuda S, Broxmeyer H. Activation of Wiskott-Aldrich syndrome protein and its association with other proteins by stromal cell-derived factor-1alpha is associated with cell migration in a T-lymphocyte line. Exp Hematol. 2002;30:761-6 pubmed
    ..Crk associated substrate (Cas), Nck, and focal adhesion kinase (FAK) were also phosphorylated after SDF-1alpha stimulation...
  59. Schlaepfer D, Hunter T. Focal adhesion kinase overexpression enhances ras-dependent integrin signaling to ERK2/mitogen-activated protein kinase through interactions with and activation of c-Src. J Biol Chem. 1997;272:13189-95 pubmed
    ..Focal adhesion kinase (FAK) associates with integrin receptors, and FN-stimulated phosphorylation of FAK at Tyr-397 and Tyr-925 promotes the ..
  60. Xie B, Zhao J, Kitagawa M, Durbin J, Madri J, Guan J, et al. Focal adhesion kinase activates Stat1 in integrin-mediated cell migration and adhesion. J Biol Chem. 2001;276:19512-23 pubmed
    Recent studies suggest that focal adhesion kinase (FAK) is important for cell migration...
  61. Vadlamudi R, Adam L, Nguyen D, Santos M, Kumar R. Differential regulation of components of the focal adhesion complex by heregulin: role of phosphatase SHP-2. J Cell Physiol. 2002;190:189-99 pubmed
    ..differentially regulates the site-specific phosphorylation of the focal adhesion components focal adhesion kinase (FAK) and paxilin in a dose-dependent manner. HRG at suboptimal doses (0.01 and 0...
  62. Canobbio I, Lova P, Sinigaglia F, Balduini C, Torti M. Proline-rich tyrosine kinase 2 and focal adhesion kinase are involved in different phases of platelet activation by vWF. Thromb Haemost. 2002;87:509-17 pubmed
    ..tyrosine kinases expressed in platelets: the proline-rich tyrosine kinase 2 (Pyk2) and the focal adhesion kinase (FAK)...
  63. Taglia L, Matusiak D, Matkowskyj K, Benya R. Gastrin-releasing peptide mediates its morphogenic properties in human colon cancer by upregulating intracellular adhesion protein-1 (ICAM-1) via focal adhesion kinase. Am J Physiol Gastrointest Liver Physiol. 2007;292:G182-90 pubmed
    ..Although we have shown that these processes are mediated by focal adhesion kinase (FAK), the downstream target(s) of GRP-induced FAK activation are not known...
  64. Golubovskaya V, Beviglia L, Xu L, Earp H, Craven R, Cance W. Dual inhibition of focal adhesion kinase and epidermal growth factor receptor pathways cooperatively induces death receptor-mediated apoptosis in human breast cancer cells. J Biol Chem. 2002;277:38978-87 pubmed
    The focal adhesion kinase (FAK) and epidermal growth factor receptor (EGFR) are protein-tyrosine kinases that are overexpressed and activated in human breast cancer...
  65. Thannickal V, Lee D, White E, Cui Z, Larios J, Chacon R, et al. Myofibroblast differentiation by transforming growth factor-beta1 is dependent on cell adhesion and integrin signaling via focal adhesion kinase. J Biol Chem. 2003;278:12384-9 pubmed
    ..TGF-beta1 induces tyrosine phosphorylation of focal adhesion kinase (FAK) including that of its autophosphorylation site, Tyr-397, an effect that is dependent on cell adhesion and is ..
  66. Itoh S, Maeda T, Shimada M, Aishima S, Shirabe K, Tanaka S, et al. Role of expression of focal adhesion kinase in progression of hepatocellular carcinoma. Clin Cancer Res. 2004;10:2812-7 pubmed
    ..The aim of this study was to investigate whether focal adhesion kinase (FAK) is involved in the progression of human HCC. Western blot analysis for FAK was performed on three HCC cell lines...
  67. Takino T, Nakada M, Miyamori H, Watanabe Y, Sato T, Gantulga D, et al. JSAP1/JIP3 cooperates with focal adhesion kinase to regulate c-Jun N-terminal kinase and cell migration. J Biol Chem. 2005;280:37772-81 pubmed
    ..for the mitogen-activated protein kinase (MAPK) cascades, and it also forms a complex with focal adhesion kinase (FAK)...
  68. Garces C, Kurenova E, Golubovskaya V, Cance W. Vascular endothelial growth factor receptor-3 and focal adhesion kinase bind and suppress apoptosis in breast cancer cells. Cancer Res. 2006;66:1446-54 pubmed
    Focal adhesion kinase (FAK) and vascular endothelial growth factor receptor-3 (VEGFR-3) are protein tyrosine kinases that are overexpressed in human cancer and play an important role in survival signaling...
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