FAF1

Summary

Gene Symbol: FAF1
Description: Fas associated factor 1
Alias: CGI-03, HFAF1s, UBXD12, UBXN3A, hFAF1, FAS-associated factor 1, Fas (TNFRSF6) associated factor 1, TNFRSF6-associated factor 1, UBX domain protein 3A, UBX domain-containing protein 12, UBX domain-containing protein 3A
Species: human
Products:     FAF1

Top Publications

  1. Ryu S, Lee S, Park M, Jun J, Jung Y, Kim E. Fas-associated factor 1, FAF1, is a member of Fas death-inducing signaling complex. J Biol Chem. 2003;278:24003-10 pubmed
    b>FAF1 has been introduced as a Fas-binding protein. However, the function of FAF1 in apoptotic execution is not established...
  2. Alexandru G, Graumann J, Smith G, Kolawa N, Fang R, Deshaies R. UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover. Cell. 2008;134:804-16 pubmed publisher
    ..The large number of ubiquitin ligases found associated with UBX proteins suggests that p97 plays a far broader role than previously anticipated in the global regulation of protein turnover. ..
  3. Song J, Park J, Lee J, Choi Y, Ryu K, Kim J, et al. Structure and interaction of ubiquitin-associated domain of human Fas-associated factor 1. Protein Sci. 2009;18:2265-76 pubmed publisher
    ..We have determined the crystal structure of the ubiquitin-associated domain of human FAF1 (hFAF1-UBA) and examined its interaction with ubiquitin and ubiquitin-like proteins using nuclear magnetic resonance...
  4. Kim H, Song E, Lee Y, Kim E, Lee K. Human Fas-associated factor 1 interacts with heat shock protein 70 and negatively regulates chaperone activity. J Biol Chem. 2005;280:8125-33 pubmed
    We examined the cell death-inducing property of human Fas-associated factor 1 (hFAF1) in the heat shock signaling pathway...
  5. Ryu S, Chae S, Lee K, Kim E. Identification and characterization of human Fas associated factor 1, hFAF1. Biochem Biophys Res Commun. 1999;262:388-94 pubmed
    We have identified and characterized a cDNA encoding human Fas associated factor 1 (hFAF1) cDNA and a shorter form of hFAF1 cDNA [hFAF1(s)] with a 456 bp internal in-frame deletion from a human HeLa cDNA library...
  6. Chu K, Niu X, Williams L. A Fas-associated protein factor, FAF1, potentiates Fas-mediated apoptosis. Proc Natl Acad Sci U S A. 1995;92:11894-8 pubmed
    ..In this study, we used the two-hybrid screen in yeast to isolate a Fas-associated protein factor, FAF1, which specifically interacts with the cytoplasmic domain of wild-type Fas but not the lprcg-mutated Fas protein...
  7. Bjørling Poulsen M, Seitz G, Guerra B, Issinger O. The pro-apoptotic FAS-associated factor 1 is specifically reduced in human gastric carcinomas. Int J Oncol. 2003;23:1015-23 pubmed
    The Fas-associated factor 1, FAF1, is a protein, which was first identified as an interaction partner of the death receptor Fas...
  8. Park M, Moon J, Lee K, Choi H, Chung J, Hong H, et al. FAF1 suppresses IkappaB kinase (IKK) activation by disrupting the IKK complex assembly. J Biol Chem. 2007;282:27572-7 pubmed
    This study presents a molecular inhibitory mechanism by Fas-associated factor 1 (FAF1) on IkappaB kinase (IKK) activation, where divergent NF-kappaB-activating stimuli converge...
  9. Ryu S, Kim E. Apoptosis induced by human Fas-associated factor 1, hFAF1, requires its ubiquitin homologous domain, but not the Fas-binding domain. Biochem Biophys Res Commun. 2001;286:1027-32 pubmed
    ..Instead, FAF1 has several domains found in proteins of ubiquitination pathway. Transient overexpression of hFAF1 in BOSC23 cells caused membrane blebbing and cell body condensation which were characteristics of apoptosis...

More Information

Publications82

  1. Guerra B, Boldyreff B, Issinger O. FAS-associated factor 1 interacts with protein kinase CK2 in vivo upon apoptosis induction. Int J Oncol. 2001;19:1117-26 pubmed
    We show here that in several different cell lines protein kinase CK2 and Fas-associated factor 1 (FAF1) exist together in a complex which is stable to high monovalent salt concentration...
  2. Song E, Yim S, Kim E, Kim N, Lee K. Human Fas-associated factor 1, interacting with ubiquitinated proteins and valosin-containing protein, is involved in the ubiquitin-proteasome pathway. Mol Cell Biol. 2005;25:2511-24 pubmed
    Human Fas-associated factor 1 (hFAF1) is a novel protein having multiubiquitin-related domains...
  3. Park M, Jang H, Lee S, Lee K, Kim E. Fas-associated factor-1 inhibits nuclear factor-kappaB (NF-kappaB) activity by interfering with nuclear translocation of the RelA (p65) subunit of NF-kappaB. J Biol Chem. 2004;279:2544-9 pubmed
    Fas-associated factor-1 (FAF1) is a Fas-binding pro-apoptotic protein that is a component of the death-inducing signaling complex in Fas-mediated apoptosis...
  4. Wang C, Hung P, Chiang C, Lombes M, Chen C, Lee K, et al. Identification of two independent SUMO-interacting motifs in Fas-associated factor 1 (FAF1): Implications for mineralocorticoid receptor (MR)-mediated transcriptional regulation. Biochim Biophys Acta Mol Cell Res. 2019;1866:1282-1297 pubmed publisher
    Fas-associated factor 1 (FAF1) was originally isolated as a Fas-associated factor and was subsequently found to interact with numerous other proteins that are involved in various cellular events including Fas-mediated apoptosis, nuclear ..
  5. Harder M, Appel E, Grarup N, Gjesing A, Ahluwalia T, Jørgensen T, et al. The type 2 diabetes risk allele of TMEM154-rs6813195 associates with decreased beta cell function in a study of 6,486 Danes. PLoS ONE. 2015;10:e0120890 pubmed publisher
    ..genome-wide association studies has identified seven novel susceptibility variants in or near TMEM154, SSR1/RREB1, FAF1, POU5F1/TCF19, LPP, ARL15 and ABCB9/MPHOSPH9...
  6. Zheng S, Lan P, Liu X, Ye K. Interaction between ribosome assembly factors Krr1 and Faf1 is essential for formation of small ribosomal subunit in yeast. J Biol Chem. 2014;289:22692-703 pubmed publisher
    ..Krr1 and Faf1 are two interacting proteins present in early 90 S precursor particles of the small ribosomal subunit...
  7. Kim J, Kim S, Lee Y. Fas-associated factor 1 promotes in neurofibrillary tangle-mediated cell death of basal forebrain cholinergic neurons in P301L transgenic mice. Neuroreport. 2015;26:767-72 pubmed publisher
    ..Our results show that Fas-associated factor 1 (FAF1) expression as well as caspase-3 activation were increased in AT8-positive MS/VDB cholinergic neurons...
  8. Peng H, Huo J, Gao Y, Chen J, Yu X, Xiao T. Fas-associated protein factor 1 is involved in meiotic resumption in mouse oocytes. J Reprod Dev. 2018;64:173-177 pubmed publisher
    Fas-associated protein factor 1 (FAF1) is a Fas-associated protein that functions in multiple cellular processes. Previous research showed that mutations in Faf1 led to the lethality of cleavage stage embryos in a mouse model...
  9. Dai T, Wu L, Wang S, Wang J, Xie F, Zhang Z, et al. FAF1 Regulates Antiviral Immunity by Inhibiting MAVS but Is Antagonized by Phosphorylation upon Viral Infection. Cell Host Microbe. 2018;24:776-790.e5 pubmed publisher
    ..We find that the scaffold protein FAF1 forms aggregates that negatively regulate MAVS...
  10. Napier M, Franceschini N, Gondalia R, Stewart J, Mendez Giraldez R, Sitlani C, et al. Genome-wide association study and meta-analysis identify loci associated with ventricular and supraventricular ectopy. Sci Rep. 2018;8:5675 pubmed publisher
    ..significant SNPs intronic to an apoptosis-enhancing gene previously associated with QRS interval duration (FAF1; lead SNP rs7545860; effect allele frequency = 0.02; P = 2...
  11. Wood A, Jonsson A, Jackson A, Wang N, van Leewen N, Palmer N, et al. A Genome-Wide Association Study of IVGTT-Based Measures of First-Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants. Diabetes. 2017;66:2296-2309 pubmed publisher
    ..the associations at the HNF1A, IGF2BP2, KCNQ1, HNF1B, VPS13C/C2CD4A, FAF1, PTPRD, AP3S2, KCNK16, MAEA, LPP, WFS1, and TMPRSS6 loci...
  12. Mi D, Cai C, Zhou B, Liu X, Ma P, Shen S, et al. Long non?coding RNA FAF1 promotes intervertebral disc degeneration by targeting the Erk signaling pathway. Mol Med Rep. 2018;17:3158-3163 pubmed publisher
    ..The present study aimed to investigate the role and molecular mechanism of Fas?associated protein factor?1 (FAF1) in IDD. The expression of FAF1 was detected by reverse transcription?quantitative polymerase chain reaction...
  13. Yu C, Kim B, Park M, Do Y, Kong Y, Kim E. FAF1 mediates necrosis through JNK1-mediated mitochondrial dysfunction leading to retinal degeneration in the ganglion cell layer upon ischemic insult. Cell Commun Signal. 2018;16:56 pubmed publisher
    ..Fas-associated factor 1 (FAF1) has been identified as a death-promoting protein...
  14. Wan Z, Song F, Sun Z, Chen Y, Zhang W, Samartzis D, et al. Aberrantly expressed long noncoding RNAs in human intervertebral disc degeneration: a microarray related study. Arthritis Res Ther. 2014;16:465 pubmed publisher
    ..Interestingly, we found that Fas-associated protein factor-1 (FAF1), which potentiates the Fas-mediated apoptosis and its nearby enhancer-like lncRNA RP11-296A18...
  15. Hyland P, Lin S, Hu N, Zhang H, Wang L, Su H, et al. Genetic variants in fas signaling pathway genes and risk of gastric cancer. Int J Cancer. 2014;134:822-31 pubmed publisher
    ..5E-04) and GCA (p = 6.3E-03), but not GNCA (p= 8.1E-02). Among examined genes in the Fas signaling pathway, MAP2K4, FAF1, MAPK8, CASP10, CASP8, CFLAR, MAP2K1, CAP8AP2, PAK2 and IKBKB were associated with risk of GC (nominal p < 0...
  16. Chen J, Ge L, Liu A, Yuan Y, Ye J, Zhong J, et al. Identification of pathways related to FAF1/H. pylori-associated gastric carcinogenesis through an integrated approach based on iTRAQ quantification and literature review. J Proteomics. 2016;131:163-176 pubmed publisher
    Previously we showed that down-regulation of tumor suppressor FAF1 mRNA, potentially caused by H. pylori, correlated with increasing tumor differentiation and distant metastasis in gastric cancer...
  17. Kim D, Basile A, Bang L, Horgusluoglu E, Lee S, Ritchie M, et al. Knowledge-driven binning approach for rare variant association analysis: application to neuroimaging biomarkers in Alzheimer's disease. BMC Med Inform Decis Mak. 2017;17:61 pubmed publisher
    ..05). In addition, the approach identified 7 evolutionary conserved regions, which were mapped to FAF1, RFX7, LYPLAL1 and GOLGA3, significantly associated with entorhinal cortex thickness (FDR-corrected p-value &..
  18. Peng H, Liu H, Liu F, Gao Y, Chen J, Huo J, et al. NLRP2 and FAF1 deficiency blocks early embryogenesis in the mouse. Reproduction. 2017;154:245-251 pubmed publisher
    ..In the present study, we identified FAF1 protein as a specific binding partner of the NLRP2 protein in both mouse oocytes and preimplantation embryos...
  19. Park E, Yoo Y, Elangovan M. The opposite role of two UBA-UBX containing proteins, p47 and SAKS1 in the degradation of a single ERAD substrate, ?-TCR. Mol Cell Biochem. 2017;425:37-45 pubmed publisher
    ..Here, we found that the expressions of all UBA-UBX genes p47, SAKS1, UBXD8, FAF1, and UBXD7 were elevated upon ER stress, albeit with different levels...
  20. Sevane N, Dunner S, Boado A, Canon J. Candidate gene analysis of osteochondrosis in Spanish Purebred horses. Anim Genet. 2016;47:570-8 pubmed publisher
    ..Of the 48 polymorphisms analysed, three single nucleotide polymorphisms (SNPs) located in the FAF1, FCN3 and COL1A2 genes were found to be associated with different locations of OC lesions...
  21. Jeong J, Yu C, Lee J, Moon K, Kim E, Yoo S, et al. Subacute toxicity evaluation of KR-33493, FAF1 inhibitor for a new anti-parkinson's disease agent, after oral administration in rats and dogs. Regul Toxicol Pharmacol. 2016;81:387-396 pubmed publisher
    KR33493, a newly developed FAS-associated factor 1 (FAF1) inhibitor for Parkinson's disease, is being evaluated in a Phase I clinical trial...
  22. Handu M, Kaduskar B, Ravindranathan R, Soory A, Giri R, Elango V, et al. SUMO-Enriched Proteome for Drosophila Innate Immune Response. G3 (Bethesda). 2015;5:2137-54 pubmed publisher
    ..Caspar, a human FAF1 ortholog that negatively regulates immune-deficient signaling, is SUMOylated at K551 and responds to treatment with ..
  23. Ogura H, Nagatake Kobayashi Y, Adachi J, Tomonaga T, Fujita N, Katayama R. TKI-addicted ROS1-rearranged cells are destined to survival or death by the intensity of ROS1 kinase activity. Sci Rep. 2017;7:5519 pubmed publisher
    ..excessive ROS1 signaling in the TKI-addicted cells phosphorylated or activated apoptosis-related molecules such as FAF1 or p38...
  24. Ernst W, Shome K, Wu C, Gong X, Frizzell R, Aridor M. VAMP-associated Proteins (VAP) as Receptors That Couple Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Proteostasis with Lipid Homeostasis. J Biol Chem. 2016;291:5206-20 pubmed publisher
    ..ligands), including the unfolded protein response sensor ATF6 and the ER degradation cluster that included FAF1, VCP, BAP31, and Derlin-1...
  25. Sonneville R, Moreno S, Knebel A, Johnson C, Hastie C, Gartner A, et al. CUL-2LRR-1 and UBXN-3 drive replisome disassembly during DNA replication termination and mitosis. Nat Cell Biol. 2017;19:468-479 pubmed publisher
    ..removed by a mitotic pathway that requires the CDC-48 cofactor UBXN-3, orthologous to the human tumour suppressor FAF1. Partial inactivation of lrr-1 and ubxn-3 leads to synthetic lethality, suggesting future approaches by which a ..
  26. Tickotsky Moskovitz N. New perspectives on the mutated NGLY1 enigma. Med Hypotheses. 2015;85:584-5 pubmed publisher
    ..Network analysis identified FAF1 (Fas-Associated Factor 1), an apoptosis-potentiating protein, as a possible degradation substrate of NGLY1...
  27. Kim H, Zhang H, Meng D, Russell G, Lee J, Ye J. UAS domain of Ubxd8 and FAF1 polymerizes upon interaction with long-chain unsaturated fatty acids. J Lipid Res. 2013;54:2144-52 pubmed publisher
    ..Long-chain unsaturated FAs also induced polymerization of Fas-associated factor 1 (FAF1), the only other mammalian protein that contains a UAS domain homologous to that of Ubxd8...
  28. Franz A, Pirson P, Pilger D, Halder S, Achuthankutty D, Kashkar H, et al. Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression. Nat Commun. 2016;7:10612 pubmed publisher
    ..Here, we report that progression of the DNA replication fork is coordinated by UBXN-3/FAF1. UBXN-3/FAF1 binds to the licensing factor CDT-1 and additional ubiquitylated proteins, thus promoting CDC-48/p97-..
  29. Hänzelmann P, Buchberger A, Schindelin H. Hierarchical binding of cofactors to the AAA ATPase p97. Structure. 2011;19:833-43 pubmed publisher
    ..Our crystal structure of the FAS-associated factor 1 (FAF1)UBX domain in complex with the p97N domain reveals that the signature Phe-Pro-Arg motif known to be crucial for ..
  30. Kang W, Yang J. Crystal structure of human FAF1 UBX domain reveals a novel FcisP touch-turn motif in p97/VCP-binding region. Biochem Biophys Res Commun. 2011;407:531-4 pubmed publisher
    UBX domain is a general p97/VCP-binding module found in an increasing number of proteins including FAF1, p47, SAKS1 and UBXD7...
  31. Knox P, Davies C, Ioannou M, Eliopoulos A. The death domain kinase RIP1 links the immunoregulatory CD40 receptor to apoptotic signaling in carcinomas. J Cell Biol. 2011;192:391-9 pubmed publisher
  32. Lim J, Lee Y, Ly T, Kang J, Lee J, An J, et al. Structural insights into the interaction of p97 N-terminus domain and VBM in rhomboid protease, RHBDL4. Biochem J. 2016;473:2863-80 pubmed publisher
    ..proteins including p47-ubiquitin regulatory X (UBX), gp78-VCP-interacting motif (VIM), OTU1-UBX-like element, and FAF1-UBX, RHBDL4 VBM also binds at the interface between the two lobes of p97N...
  33. Edwards A, Aliev F, Bierut L, Bucholz K, Edenberg H, Hesselbrock V, et al. Genome-wide association study of comorbid depressive syndrome and alcohol dependence. Psychiatr Genet. 2012;22:31-41 pubmed publisher
    ..These results underscore the complex genomic influences on psychiatric phenotypes and suggest that a comorbid phenotype is partially influenced by genetic variants that do not affect AD alone. ..
  34. Park M, Ryu S, Kim K, Lim J, Lee Z, Kim E. Fas-associated factor-1 mediates chemotherapeutic-induced apoptosis via death effector filament formation. Int J Cancer. 2005;115:412-8 pubmed
    Fas-associated factor-1 (FAF1) is a newly introduced member of the Fas death-inducing signaling complex and potentiates Fas-mediated apoptosis. Clinical study has revealed that FAF1 is significantly reduced in gastric carcinomas...
  35. Yu C, Kim B, Kim E. FAF1 mediates regulated necrosis through PARP1 activation upon oxidative stress leading to dopaminergic neurodegeneration. Cell Death Differ. 2016;23:1873-1885 pubmed publisher
    ..Here, we describe a novel role for Fas-associated factor 1 (FAF1) as a crucial regulator of necrotic cell death elicited by hydrogen peroxide...
  36. Elmetwali T, Young L, Palmer D. Fas-associated factor (Faf1) is a novel CD40 interactor that regulates CD40-induced NF-?B activation via a negative feedback loop. Cell Death Dis. 2014;5:e1213 pubmed publisher
    ..Fas-Associated Factor 1(FAF1) was isolated from a HeLa cDNA library using the CD40 cytoplasmic tail (216-278 aa) as a bait construct...
  37. Buchberger A, Howard M, Proctor M, Bycroft M. The UBX domain: a widespread ubiquitin-like module. J Mol Biol. 2001;307:17-24 pubmed
    ..of UBX domains, we solved the three-dimensional structure of the UBX domain of human Fas-associated factor-1 (FAF1) by NMR spectroscopy...
  38. Betarbet R, Anderson L, Gearing M, Hodges T, Fritz J, Lah J, et al. Fas-associated factor 1 and Parkinson's disease. Neurobiol Dis. 2008;31:309-15 pubmed publisher
    Fas-associated factor 1 or FAF1 is a Fas-binding protein implicated in apoptosis. FAF1 is the product of a gene at PARK 10 locus on chromosome 1p32, a locus associated with late-onset PD [Hicks, A.A., Petursson, H., Jonsson, T...
  39. Lee J, Kim Y, Jeong J, Bae D, Lee K. Ubiquitin-associated (UBA) domain in human Fas associated factor 1 inhibits tumor formation by promoting Hsp70 degradation. PLoS ONE. 2012;7:e40361 pubmed publisher
    Human Fas associated factor 1 (hFAF1) is a pro-apoptotic scaffolding protein containing ubiquitin-associating (UBA), ubiquitin like 1 and 2 (UBL1, UBL2), and ubiquitin regulatory X (UBX) domains...
  40. Zhang L, Zhou F, Li Y, Drabsch Y, Zhang J, van Dam H, et al. Fas-associated factor 1 is a scaffold protein that promotes ?-transducin repeat-containing protein (?-TrCP)-mediated ?-catenin ubiquitination and degradation. J Biol Chem. 2012;287:30701-10 pubmed publisher
    FAS-associated factor 1 (FAF1) antagonizes Wnt signaling by stimulating ?-catenin degradation. However, the molecular mechanism underlying this effect is unknown...
  41. Alexandru G. Exploring the role of p97 and its UBX-domain cofactors through identification of their interacting proteins. Methods Mol Biol. 2012;832:305-12 pubmed publisher
    ..This approach aims to dissect the role played by individual UBX cofactors within the complex array of cellular functions performed by p97. ..
  42. Cerutti E, Campagnoli M, Ferretti M, Garelli E, Crescenzio N, Rosolen A, et al. Co-inherited mutations of Fas and caspase-10 in development of the autoimmune lymphoproliferative syndrome. BMC Immunol. 2007;8:28 pubmed
    ..In both patients, the mutations were inherited from distinct healthy parents. These data strongly suggest that co-transmission of these mutation was responsible for ALPS. ..
  43. Sotoodehnia N, Isaacs A, de Bakker P, Dorr M, Newton Cheh C, Nolte I, et al. Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction. Nat Genet. 2010;42:1068-76 pubmed publisher
    ..These findings extend our current knowledge of ventricular depolarization and conduction...
  44. Weersma R, Stokkers P, Cleynen I, Wolfkamp S, Henckaerts L, Schreiber S, et al. Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort. Am J Gastroenterol. 2009;104:630-8 pubmed publisher
    ..We show that a genetic risk profile can be constructed that is clinically useful and that can aid in making treatment decisions. ..
  45. Wei G, Xu Y, Peng T, Yan J, Wang Z, Sun Z. Sanguinarine exhibits antitumor activity via up-regulation of Fas-associated factor 1 in non-small cell lung cancer. J Biochem Mol Toxicol. 2017;31: pubmed publisher
    ..SNG increased Fas-associated factor 1 (FAF1) expression and upregulation of FAF1 inhibited cell proliferation, invasion, and migration and induced cell cycle ..
  46. Caballero López M, Nieto Diaz M, Yunta M, Reigada D, Muñoz Galdeano T, Del Águila A, et al. XIAP Interacts with and Regulates the Activity of FAF1. Biochim Biophys Acta Mol Cell Res. 2017;1864:1335-1348 pubmed publisher
    ..While searching for novel interacting partners of XIAP, we identified Fas-associated factor 1 (FAF1)...
  47. Kang W, Yang J. Crystallization and preliminary X-ray crystallographic analysis of the hexameric human p97/VCP ND1 fragment in complex with the UBX domain of human FAF1. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011;67:1199-202 pubmed publisher
    The UBX domain of Fas-associated factor 1 (FAF1) binds to the N domain of p97/VCP, a multi-functional hexameric ATPase, and FAF1 thus inhibits the proteasome-mediated protein-degradation process assisted by p97/VCP...
  48. Juo P, Kuo C, Yuan J, Blenis J. Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade. Curr Biol. 1998;8:1001-8 pubmed
    ..This study provides the first genetic evidence that caspase-8 occupies an essential and apical position in the Fas signaling pathway and suggests that caspase-8 may participate broadly in multiple apoptotic pathways. ..
  49. Kusk M, Ahmed R, Thomsen B, Bendixen C, Issinger O, Boldyreff B. Interactions of protein kinase CK2beta subunit within the holoenzyme and with other proteins. Mol Cell Biochem. 1999;191:51-8 pubmed
    ..partners have been identified, among them the S6 kinase p90rsk, the putative tumor suppressor protein Doc-1, the Fas-associated protein FAF1, the mitochondrial translational initiation factor 2 and propionyl CoA carboxylase beta subunit.
  50. Pinheiro A, Eibl C, Ekman Vural Z, Schwarzenbacher R, Peti W. The NLRP12 pyrin domain: structure, dynamics, and functional insights. J Mol Biol. 2011;413:790-803 pubmed publisher
    ..Finally, we experimentally highlight a significant role for tryptophan 45 in the interaction between NLRP12 PYD and the FAF-1 UBA domain. ..
  51. Imai Y, Nakada A, Hashida R, Sugita Y, Tanaka T, Tsujimoto G, et al. Cloning and characterization of the highly expressed ETEA gene from blood cells of atopic dermatitis patients. Biochem Biophys Res Commun. 2002;297:1282-90 pubmed
    ..of the 445 aa deduced polypeptide from the cloned ETEA cDNA showed homology to human Fas-associated factor 1 (FAF1), which is involved in Fas-mediated apoptosis...
  52. Olsen B, Jessen V, Højrup P, Issinger O, Boldyreff B. Protein kinase CK2 phosphorylates the Fas-associated factor FAF1 in vivo and influences its transport into the nucleus. FEBS Lett. 2003;546:218-22 pubmed
    We previously identified the Fas-associated factor FAF1 as an in vitro substrate of protein kinase CK2 and determined Ser289 and Ser291 as phosphorylation sites...
  53. Rao P, Zhou Y, Ge S, Wang A, Yu X, Alzain M, et al. Validation of Type 2 Diabetes Risk Variants Identified by Genome-Wide Association Studies in Northern Han Chinese. Int J Environ Res Public Health. 2016;13: pubmed publisher
    ..The allelic frequency of the "A" allele at rs17106184 (Fas-associated factor 1, FAF1) was significantly higher in the T2DM patients than that of the healthy controls (11.7% vs. 6.4%, p < 0.001)...
  54. Kinoshita T, Kondoh C, Hasegawa M, Imamura R, Suda T. Fas-associated factor 1 is a negative regulator of PYRIN-containing Apaf-1-like protein 1. Int Immunol. 2006;18:1701-6 pubmed
    ..Here, we used yeast two-hybrid assays to identify Fas-associated factor 1 (FAF1) as a protein interacting with the pyrin domains of several PYPAFs...
  55. Kim H, Rodriguez Navas C, Kollipara R, Kapur P, Pedrosa I, Brugarolas J, et al. Unsaturated Fatty Acids Stimulate Tumor Growth through Stabilization of β-Catenin. Cell Rep. 2015;13:495-503 pubmed publisher
    ..Unsaturated FAs bind to the UAS domain of Fas-associated factor 1 (FAF1), a protein known to bind β-catenin, accelerating its degradation...
  56. Shin H, Kang W, Lee S, Yang J. Crystallization and preliminary X-ray crystallographic analysis of the N domain of p97/VCP in complex with the UBX domain of FAF1. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010;66:41-3 pubmed publisher
    ..Among these adaptors are p47 and Fas-associated factor 1 (FAF1), which contain a common UBX domain through which they bind to the N domain of p97/VCP...
  57. Stoletov K, Terman B. Bmx is a downstream Rap1 effector in VEGF-induced endothelial cell activation. Biochem Biophys Res Commun. 2004;320:70-5 pubmed
    ..Formation of a Rap1/Bmx complex was not observed in cells transfected with an expression vector for a dominant-negative Rap1, indicating that Bmx is a downstream Rap1 effector in VEGF-induced endothelial cell activation. ..
  58. Kim J, Park M, Nikapitiya C, Kim T, Uddin M, Lee H, et al. FAS-associated factor-1 positively regulates type I interferon response to RNA virus infection by targeting NLRX1. PLoS Pathog. 2017;13:e1006398 pubmed publisher
    FAS-associated factor-1 (FAF1) is a component of the death-inducing signaling complex involved in Fas-mediated apoptosis. It regulates NF-κB activity, ubiquitination, and proteasomal degradation...
  59. Qin W, Shi Y, Zhao B, Yao C, Jin L, Ma J, et al. miR-24 regulates apoptosis by targeting the open reading frame (ORF) region of FAF1 in cancer cells. PLoS ONE. 2010;5:e9429 pubmed publisher
    ..In the present study, miR-24 was found to target fas associated factor 1(FAF1) by binding to its amino acid coding sequence (CDS) region, thereby regulating apoptosis in DU-145 ..
  60. Ghassibe Sabbagh M, Desmyter L, Langenberg T, Claes F, Boute O, Bayet B, et al. FAF1, a gene that is disrupted in cleft palate and has conserved function in zebrafish. Am J Hum Genet. 2011;88:150-61 pubmed publisher
    ..Here we show that Fas-associated factor-1 (FAF1) is disrupted and that its expression is decreased in a Pierre Robin family with an inherited translocation...
  61. Zhang L, Zhou F, van Laar T, Zhang J, van Dam H, Ten Dijke P. Fas-associated factor 1 antagonizes Wnt signaling by promoting ?-catenin degradation. Mol Biol Cell. 2011;22:1617-24 pubmed publisher
    ..Here, we identify Fas-associated factor 1 (FAF1) as a negative regulator of Wnt/?-catenin signaling...
  62. Cleynen I, Mahachie John J, Henckaerts L, Van Moerkercke W, Rutgeerts P, Van Steen K, et al. Molecular reclassification of Crohn's disease by cluster analysis of genetic variants. PLoS ONE. 2010;5:e12952 pubmed publisher
    ..The used technique can be applied to other common complex diseases as well, and will help to complete patient characterization, in order to evolve towards personalized medicine. ..
  63. Do Y, Yun S, Park M, Kim E. The M458L missense mutation disrupts the catalytic properties of Parkin. FEBS Lett. 2017;: pubmed publisher
    ..We show that the M458L mutant retains its autoubiquitination potential in vitro but not in cells. FAF1 and p38 (substrates of Parkin) are able to bind to the M458L mutant in cells; however, these Parkin substrates are ..
  64. Cheng K, Bai L, Belluscio L. Fas-associated factor 1 as a regulator of olfactory axon guidance. J Neurosci. 2011;31:11905-13 pubmed publisher
    ..we use the mouse olfactory system as an in vivo model to demonstrate that by modulating Fas-associated factor 1 (FAF1), an apoptosis regulatory molecule, we can rewire axonal projections...
  65. Hänzelmann P, Schindelin H. The structural and functional basis of the p97/valosin-containing protein (VCP)-interacting motif (VIM): mutually exclusive binding of cofactors to the N-terminal domain of p97. J Biol Chem. 2011;286:38679-90 pubmed publisher
    ..These results extend the concept that competitive binding is a crucial determinant in p97-cofactor interactions. ..
  66. Song S, Lee J, Kim H, Lee J, Chang J, Lee K. Fas-Associated Factor 1 Negatively Regulates the Antiviral Immune Response by Inhibiting Translocation of Interferon Regulatory Factor 3 to the Nucleus. Mol Cell Biol. 2016;36:1136-51 pubmed publisher
    This study is designed to examine the cellular functions of human Fas-associated factor 1 (FAF1) containing multiple ubiquitin-related domains...
  67. Lee J, Park J, Jeong J, Jeon H, Yoon J, Kim E, et al. Complex of Fas-associated factor 1 (FAF1) with valosin-containing protein (VCP)-Npl4-Ufd1 and polyubiquitinated proteins promotes endoplasmic reticulum-associated degradation (ERAD). J Biol Chem. 2013;288:6998-7011 pubmed publisher
    Fas-associated factor 1 (FAF1) is a ubiquitin receptor containing multiple ubiquitin-related domains including ubiquitin-associated (UBA), ubiquitin-like (UBL) 1, UBL2, and ubiquitin regulatory X (UBX)...
  68. Kang W, Shin H, Yang J. Crystallization and preliminary X-ray crystallographic analysis of human FAF1 UBX domain. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010;66:211-3 pubmed publisher
    Fas-associated factor 1 (FAF1) is a multifunctional pro-apoptotic protein that is involved in Fas-mediated apoptosis, NF-kappaB signalling and the ubiquitin-proteasome pathway...
  69. Liu A, Xie Z, Chen X, Feng J, Chen J, Qin F, et al. Fas-associated factor 1 inhibits tumor growth by suppressing Helicobacter pylori-induced activation of NF-κB signaling in human gastric carcinoma. Oncotarget. 2017;8:7999-8009 pubmed publisher
    Loss of Fas-associated factor 1 (FAF1) may act as a pro-survival signal in diseased cells, but whether this is true in gastric carcinoma remains unclear...
  70. Jang M, Sul J, Choi B, Lee S, Suh J, Kim N, et al. Negative feedback regulation of Aurora-A via phosphorylation of Fas-associated factor-1. J Biol Chem. 2008;283:32344-51 pubmed publisher
    This study reports that Aurora-A (Aur-A) phosphorylates Fas-associated factor-1 (FAF1) at Ser-289 and Ser-291...
  71. Allen M, Buchberger A, Bycroft M. The PUB domain functions as a p97 binding module in human peptide N-glycanase. J Biol Chem. 2006;281:25502-8 pubmed
    ..Furthermore, we show that the PUB and UBX domains do not bind to p97 in a mutually exclusive manner. Our results suggest that PUB domain-containing proteins constitute a widespread family of diverse p97 cofactors. ..
  72. De Haro L, Janknecht R. Functional analysis of the transcription factor ER71 and its activation of the matrix metalloproteinase-1 promoter. Nucleic Acids Res. 2002;30:2972-9 pubmed
    ..Altogether, these data represent the first functional characterization of ER71, which may perform important functions in the developing and adult testis as well as in testicular germ cell tumorigenesis. ..
  73. Jensen H, Hjerrild M, Guerra B, Larsen M, Højrup P, Boldyreff B. Phosphorylation of the Fas associated factor FAF1 by protein kinase CK2 and identification of serines 289 and 291 as the in vitro phosphorylation sites. Int J Biochem Cell Biol. 2001;33:577-89 pubmed
    We previously identified the human Fas associated factor (FAF1) as one of the interacting partners of protein kinase CK2 beta subunit. Since FAF1 is a phosphoprotein we investigated whether it is a substrate for CK2...