FADS3

Summary

Gene Symbol: FADS3
Description: fatty acid desaturase 3
Alias: CYB5RP, LLCDL3, cytochrome b5-related protein, delta-9 fatty acid desaturase, delta-9-desaturase, linoleoyl-CoA desaturase (delta-9-desaturase)-like 3
Species: human

Top Publications

  1. ncbi cDNA cloning, genomic structure, and chromosomal localization of three members of the human fatty acid desaturase family
    A Marquardt
    Institute of Human Genetics, University of Wurzburg, Wurzburg, 97074, Germany
    Genomics 66:175-83. 2000
  2. pmc Genome-wide association study of plasma polyunsaturated fatty acids in the InCHIANTI Study
    Toshiko Tanaka
    MedStar Research Institute, Baltimore, MD, USA
    PLoS Genet 5:e1000338. 2009
  3. ncbi Comparison of the reactivity of tetradecenoic acids, a triacsin, and unsaturated oximes with four purified Saccharomyces cerevisiae fatty acid activation proteins
    L J Knoll
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 270:20090-7. 1995
  4. doi Fatty acid composition of milk from multiparous Holstein cows treated with bovine somatotropin and fed n-3 fatty acids in early lactation
    M Carriquiry
    Department of Animal Science, University of Minnesota, St Paul 55108 6118, USA
    J Dairy Sci 92:4865-75. 2009
  5. ncbi Fatty acid profile of erythrocyte membranes as possible biomarker of longevity
    Annibale A Puca
    IRCCS Policlinico Multimedica, Milan, Italy
    Rejuvenation Res 11:63-72. 2008
  6. ncbi Short communication: indigestible markers reduce the mammary Delta9-desaturase index and alter the milk fatty acid composition in cows
    K J Shingfield
    Animal Production Research, MTT Agrifood Research Finland, FIN 31600, Jokioinen, Finland
    J Dairy Sci 89:3006-10. 2006
  7. ncbi Temperature-regulated mRNA accumulation and stabilization for fatty acid desaturase genes in the cyanobacterium Synechococcus sp. strain PCC 7002
    T Sakamoto
    Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park 16802, USA
    Mol Microbiol 23:1281-92. 1997
  8. pmc Identification of Rv3230c as the NADPH oxidoreductase of a two-protein DesA3 acyl-CoA desaturase in Mycobacterium tuberculosis H37Rv
    Yong Chang
    Biophysics Graduate Degree Program and Department of Biochemistry, University of Wisconsin, 433 Babcock Drive, Madison, Wisconsin 53706 1549, USA
    Biochemistry 45:13476-86. 2006
  9. ncbi Characterization of NO adducts of the diiron center in protein R2 of Escherichia coli ribonucleotide reductase and site-directed variants; implications for the O2 activation mechanism
    Shen Lu
    Department of Environmental and Biomolecular Systems, OGI School of Science and Engineering, Oregon Health and Science University, Beaverton, OR 97006 8921, USA
    J Biol Inorg Chem 9:818-27. 2004
  10. ncbi Juvenile neuronal ceroid-lipofuscinosis (Batten disease): a brief review and update
    Dinesh Rakheja
    Department of Pathology, UT Southwestern Medical Center and Children s Medical Center, Dallas, TX 75390, USA
    Curr Mol Med 7:603-8. 2007

Research Grants

  1. IRON OXO CLUSTERS AND FATTY ACID DESATURATION
    Brian Fox; Fiscal Year: 1999
  2. Synthetic Models and Spectroscopy of Metal-Oxo Proteins
    Lawrence Que; Fiscal Year: 2006
  3. Genetic modification of PUFA biosynthesis and CHD
    Ana Baylin; Fiscal Year: 2006
  4. Genetic modification of PUFA biosynthesis and CHD
    Ana Baylin; Fiscal Year: 2007
  5. REGULATION OF FATTY ACID METABOLISM
    Charles Martin; Fiscal Year: 2002
  6. REGULATION OF FATTY ACID METABOLISM
    Charles Martin; Fiscal Year: 1992
  7. Molecular and Cellular Biology of Lipids
    Charles Martin; Fiscal Year: 2007
  8. GCx(py)GCC-IRMS for Isotope Metabolomics
    JAMES T BRENNA; Fiscal Year: 2010
  9. Gas phase derivatization for lipidomic MS analysis
    JAMES BRENNA; Fiscal Year: 2007
  10. PRECISE ISOTOPE RATIO CHROMATOGRAPHY AND STABLE TRACERS
    JAMES BRENNA; Fiscal Year: 2004

Scientific Experts

Detail Information

Publications118 found, 100 shown here

  1. ncbi cDNA cloning, genomic structure, and chromosomal localization of three members of the human fatty acid desaturase family
    A Marquardt
    Institute of Human Genetics, University of Wurzburg, Wurzburg, 97074, Germany
    Genomics 66:175-83. 2000
    ..A third member, fatty acid desaturase-3 (FADS3), was identified in silico revealing 62 and 70% nucleotide sequence identity with FADS1 and FADS2, respectively...
  2. pmc Genome-wide association study of plasma polyunsaturated fatty acids in the InCHIANTI Study
    Toshiko Tanaka
    MedStar Research Institute, Baltimore, MD, USA
    PLoS Genet 5:e1000338. 2009
    ..for association was observed in a region of chromosome 11 that encodes three fatty acid desaturases (FADS1, FADS2, FADS3)...
  3. ncbi Comparison of the reactivity of tetradecenoic acids, a triacsin, and unsaturated oximes with four purified Saccharomyces cerevisiae fatty acid activation proteins
    L J Knoll
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 270:20090-7. 1995
    ..cis-double bond is a feature it shares with Faa3p and is notable since in yeast Ole1p, a microsomal cis-delta 9 desaturase, accounts for de novo production of monoenoic acyl-CoAs from saturated acyl-CoA substrates...
  4. doi Fatty acid composition of milk from multiparous Holstein cows treated with bovine somatotropin and fed n-3 fatty acids in early lactation
    M Carriquiry
    Department of Animal Science, University of Minnesota, St Paul 55108 6118, USA
    J Dairy Sci 92:4865-75. 2009
    ..10, 0.09, 0.08, and 0.09 +/- 0.01 for SSN, SSY, AFN, and AFY, respectively). Feeding Alifet-Repro increased n-3 fatty acids in milk and bST prolonged the partitioning of dietary fatty acids into milk fat...
  5. ncbi Fatty acid profile of erythrocyte membranes as possible biomarker of longevity
    Annibale A Puca
    IRCCS Policlinico Multimedica, Milan, Italy
    Rejuvenation Res 11:63-72. 2008
    ..We concluded that erythrocyte membranes derived from nonagenarian offspring have a different lipid composition (reduced lipid peroxidation and increased membrane integrity) to that of the general population...
  6. ncbi Short communication: indigestible markers reduce the mammary Delta9-desaturase index and alter the milk fatty acid composition in cows
    K J Shingfield
    Animal Production Research, MTT Agrifood Research Finland, FIN 31600, Jokioinen, Finland
    J Dairy Sci 89:3006-10. 2006
    ..6, 52.7, 58.7, 36.8, 37.2, 44.3, and 43.0%, respectively. In conclusion, one or more of the markers administered altered milk fatty acid composition and may act as an inhibitor of Delta(9)-desaturase in the bovine mammary gland...
  7. ncbi Temperature-regulated mRNA accumulation and stabilization for fatty acid desaturase genes in the cyanobacterium Synechococcus sp. strain PCC 7002
    T Sakamoto
    Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park 16802, USA
    Mol Microbiol 23:1281-92. 1997
    ..The desB (omega 3 desaturase) and desC (delta 9 desaturase) genes of Synechococcus sp...
  8. pmc Identification of Rv3230c as the NADPH oxidoreductase of a two-protein DesA3 acyl-CoA desaturase in Mycobacterium tuberculosis H37Rv
    Yong Chang
    Biophysics Graduate Degree Program and Department of Biochemistry, University of Wisconsin, 433 Babcock Drive, Madison, Wisconsin 53706 1549, USA
    Biochemistry 45:13476-86. 2006
    ..tuberculosis H37Rv to minimally consist of a soluble Rv3230c reductase and integral membrane DesA3 desaturase. Further implications of this finding relative to the properties of other multiprotein iron-enzyme complexes are discussed...
  9. ncbi Characterization of NO adducts of the diiron center in protein R2 of Escherichia coli ribonucleotide reductase and site-directed variants; implications for the O2 activation mechanism
    Shen Lu
    Department of Environmental and Biomolecular Systems, OGI School of Science and Engineering, Oregon Health and Science University, Beaverton, OR 97006 8921, USA
    J Biol Inorg Chem 9:818-27. 2004
    ..The formation of equivalent NO adducts in the wt and variant proteins strongly favors the formation of a symmetric bridging peroxo intermediate during the O(2) activation process in R2-wt...
  10. ncbi Juvenile neuronal ceroid-lipofuscinosis (Batten disease): a brief review and update
    Dinesh Rakheja
    Department of Pathology, UT Southwestern Medical Center and Children s Medical Center, Dallas, TX 75390, USA
    Curr Mol Med 7:603-8. 2007
    ..In this review, following an introduction to the neuronal ceroid-lipofuscinoses, we provide a brief overview and an update of the most recent research in JNCL, specifically that related to the function of CLN3P...
  11. ncbi Down-regulated expression of PPARalpha target genes, reduced fatty acid oxidation and altered fatty acid composition in the liver of mice transgenic for hTNFalpha
    Heidi Glosli
    Biotechnology Centre of Oslo, University of Oslo, Oslo, Norway
    Biochim Biophys Acta 1734:235-46. 2005
    ..This is not due to de novo fatty acid synthesis as both FAS activity and gene expression of ACC2 were reduced...
  12. doi Effect of plant oils in the diet on performance and milk fatty acid composition in goats fed diets based on grass hay or maize silage
    Laurence Bernard
    INRA, UR1213 Herbivores, Equipe Tissu Adipeux et Lipides du Lait, Site de Theix, F 63122 Saint Genes Champanelle, France
    Br J Nutr 101:213-24. 2009
    ..In conclusion, plant oils represent an effective strategy for altering the fatty acid composition of caprine milk, with evidence that the basal diet is an important determinant of ruminal unsaturated fatty acid metabolism in the goat...
  13. ncbi Nuclear factor 1 is essential for the expression of stearoyl-CoA desaturase 1 gene during preadipocyte differentiation
    M V Singh
    Department of Biochemistry, University of Wisconsin Madison 53706, USA
    Biochim Biophys Acta 1398:148-56. 1998
    Stearoyl CoA desaturase gene 1 (SCD1) is a delta 9 desaturase that is transcriptionally activated during the differentiation of 3T3-L1 preadipocytes into adipocytes...
  14. doi Transplastomic tobacco plants expressing a fatty acid desaturase gene exhibit altered fatty acid profiles and improved cold tolerance
    Wendy Craig
    CNR IGV, Institute of Plant Genetics Portici, Portici, NA, Italy
    Transgenic Res 17:769-82. 2008
    ..In fact, the transplastomic plants expressing the S. commersonii gene contain only plant-derived sequences, a clear attraction from a public acceptability perspective...
  15. pmc Changes in membrane fluid state and heat shock response cause attenuation of virulence
    Amalia Porta
    University of Salerno, Department of Pharmaceutical Sciences, Faculty of Pharmacy, Division of Biomedicine, Salerno, Italy
    J Bacteriol 192:1999-2005. 2010
    ..This new procedure to generate attenuated forms of pathogens may be used eventually to produce a novel class of vaccines based on the genetic manipulation of a pathogen's membrane fluid state and stress response...
  16. ncbi Chemical and posttranslational modification of Escherichia coli acyl carrier protein for preparation of dansyl-acyl carrier proteins
    J A Haas
    Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706, USA
    Protein Expr Purif 20:274-84. 2000
    ..The efficient in vivo phosphopantetheinylation of E. coli apo-ACP by coexpression with holo-ACP synthase in E. coli BL21(DE3) using fructose as the carbon source is also reported...
  17. ncbi Effect of a high linoleic acid diet on delta 9-desaturase activity, lipogenesis and lipid composition of pig subcutaneous adipose tissue
    M Kouba
    Ensa de Rennes, France
    Reprod Nutr Dev 38:31-7. 1998
    ..The present study suggests that delta 9-desaturase could be involved in the regulation of monounsaturated fatty acid content and hence in the quality of pig adipose tissue...
  18. ncbi The OLE1 gene of Saccharomyces cerevisiae encodes the delta 9 fatty acid desaturase and can be functionally replaced by the rat stearoyl-CoA desaturase gene
    J E Stukey
    Nelson Biological Laboratory, Rutgers University, Piscataway, New Jersey 08855 1059
    J Biol Chem 265:20144-9. 1990
    ..yeast genomic fragment complementing the ole1 mutation has been sequenced and determined to encode the delta 9 fatty acid desaturase enzyme by comparison of primary amino acid sequence to the rat liver stearoyl-CoA desaturase...
  19. ncbi Delta-9 fatty acid desaturase gene containing a carboxyl-terminal cytochrome b5 domain from the red alga Cyanidioschyzon merolae
    R Itoh
    Department of Biological Sciences, Graduate School of Science, University of Tokyo, Hongo, Tokyo 113 0033, Japan
    Curr Genet 33:165-70. 1998
    ..The discovery of CmFAD9 indicates the existence of a novel type of plant delta-9 fatty acid desaturase that may function in the endoplasmic reticulum, but not in the plastid...
  20. pmc Genetic regulation of unsaturated fatty acid composition in C. elegans
    Trisha J Brock
    Institute of Biological Chemistry, Washington State University, Pullman, Washington, USA
    PLoS Genet 2:e108. 2006
    ..We conclude that, like mammals, C. elegans requires adequate synthesis of unsaturated fatty acids and maintains complex regulation of the delta-9 desaturases to achieve optimal fatty acid composition...
  21. ncbi Changes in conjugated linoleic acid and palmitoleic acid are correlated to retinol levels in chronic renal failure in both hemodialysis and conservative treatment patients
    Leonardo Lucchi
    Department of Internal Medicine, Division of Nephrology, Dialysis and Transplantation, University Hospital Modena, Modena, Italy
    Artif Organs 29:413-8. 2005
    ..The influence of retinol levels on these fatty acids might be due to an induction of delta 9 desaturase. In fact, 16:1 is known to be produced, partly, by delta 9 desaturation of palmitic acid...
  22. doi Fetal bovine serum concentration affects delta9 desaturase activity of Trypanosoma cruzi
    Ana L Villasuso
    Departamento de Biologia Molecular, Facultad de Ciencias Exactas, Fisico Quimicas y Naturales, Universidad Nacional de Rio Cuarto, CPX5804BYA, Rio Cuarto, Cordoba, Argentina
    Lipids 45:275-83. 2010
    ..The results suggest that decreased FBS in culture medium is a signal that modulates (9) desaturase activity in T. cruzi epimastigotes...
  23. pmc Plasma and erythrocyte fatty acid patterns in patients with recurrent depression: a matched case-control study
    Johanna Assies
    Program for Mood Disorders, Department of Psychiatry, Academic Medical Centre, Amsterdam, The Netherlands
    PLoS ONE 5:e10635. 2010
    ....
  24. ncbi Vaccenic acid and cis-9,trans-11 CLA in the rumen and different tissues of pasture- and concentrate-fed beef cattle
    Xiangzhen Shen
    Nanjing Agricultural University, Nanjing, 210095, China
    Lipids 42:1093-103. 2007
    ..There was a linear relationship between the concentration of VA and cis-9,trans-11 CLA and the coefficients of determination (R (2)) varied between 0.29 and 0.87 from rumen to the different tissues...
  25. pmc Gene expression pattern of functional neuronal cells derived from human bone marrow mesenchymal stromal cells
    Tatiana Tondreau
    Institut Jules Bordet, Universite Libre de Bruxelles, Laboratory of Experimental Hematology, 121, Bd de Waterloo, 1000 Brussels, Belgium
    BMC Genomics 9:166. 2008
    ..Indeed, many studies have demonstrated that MSC can give rise to neuronal cells as well as many tissue-specific cell phenotypes...
  26. pmc Stearoyl-CoA desaturase and its relation to high-carbohydrate diets and obesity
    Matthew T Flowers
    Department of Biochemistry, University of Wisconsin, 433 Babcock Drive, Madison, Wisconsin 53706, USA
    Biochim Biophys Acta 1791:85-91. 2009
    ..In this review, we address the association of high-carbohydrate diets with increased SCD activity and summarize the current literature on the subject of SCD1 and body weight regulation...
  27. doi Responses of Pacific oyster Crassostrea gigas populations to abiotic stress in environmentally contrasted estuaries along the Atlantic coast of France
    Elise David
    Laboratoire des Sciences de l Environnement Marin LEMAR, UMR CNRS 6539, Institut Universitaire Europeen de la Mer, Universite de Bretagne Occidentale, Place Nicolas Copernic, 29280 Plouzane, France
    Aquat Toxicol 109:70-9. 2012
    ..The MT4 gene is a good physiological and genetic marker of stress response and susceptibility...
  28. doi Biosynthesis of gamma-linolenic acid and beta-carotene by Zygomycetes fungi
    Tatiana Klempova
    Department of Biochemical Technology, Faculty of Chemical and Food Technology, Slovak University of Technology, Bratislava, Slovakia
    Biotechnol J 8:794-800. 2013
    ..Such knowledge about fatty acid desaturase activities provides new challenges for the regulation of biotechnological production of PUFAs by Zygomycetes fungi. ..
  29. pmc Alternative transcripts of fatty acid desaturase (FADS) genes
    J Thomas Brenna
    Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA
    Prostaglandins Leukot Essent Fatty Acids 82:281-5. 2010
    ..We recently reported positive identification of the first alternative transcripts (AT) of fatty acid desaturase 3 (FADS3) and FADS2 in fetal and neonatal baboons...
  30. doi Milk fatty acid profile and dairy sheep performance in response to diet supplementation with sunflower oil plus incremental levels of marine algae
    P G Toral
    Instituto de Ganadería de Montaña CSIC ULE, Finca Marzanas s n 24346 Grulleros, Leon, Spain
    J Dairy Sci 93:1655-67. 2010
    ....
  31. doi Effect of diet, sex and age on fatty acid metabolism in broiler chickens: SFA and MUFA
    R Poureslami
    Laboratory for Animal Nutrition and Animal Product Quality, Department of Animal Production, Ghent University, Proefhoevestraat 10, 9090 Melle, Belgium
    Br J Nutr 104:204-13. 2010
    ..Total ex novo production and beta-oxidation of SFA and MUFA showed a negative and positive curvilinear relationship with net intake of SFA and MUFA, respectively. Sex had no effect on SFA and MUFA metabolism...
  32. doi The 51 kDa FADS3 is Secreted in the ECM of Hepatocytes and Blood in Rat
    Hélène Blanchard
    Laboratoire de Biochimie et Nutrition Humaine, INRA USC 2012, Agrocampus Ouest, F 35042, Rennes, France
    J Cell Biochem 115:199-207. 2014
    The fatty acid desaturase (Fads) cluster is composed of three genes encoding for the Δ5- and Δ6-desaturases and FADS3. The two former proteins are involved in the fatty acid biosynthesis; the latter one shares a high sequence identity ..
  33. pmc Identification and functional analysis of delta-9 desaturase, a key enzyme in PUFA Synthesis, isolated from the oleaginous diatom Fistulifera
    Masaki Muto
    Division of Biotechnology and Life Science, Institute of Engineering, Tokyo University of Agriculture and Technology, Koganei, Tokyo, Japan JST, CREST, Sanbancho 5, Chiyoda ku, Tokyo, Japan
    PLoS ONE 8:e73507. 2013
    ..The findings will provide beneficial insights into applying metabolic engineering processes to suppressing PUFA synthesis in this oleaginous microalgal strain. ..
  34. pmc Dietary arachidonic acid and docosahexaenoic acid regulate liver fatty acid desaturase (FADS) alternative transcript expression in suckling piglets
    Vasuki Wijendran
    Department of Pediatrics, Massachusetts General Hospital for Children, Harvard Medical School, Boston, MA, USA
    Prostaglandins Leukot Essent Fatty Acids 89:345-50. 2013
    ..The objective of the current study was to determine regulation of liver Fads1, Fads2 and Fads3 classical (CS) and alternative transcripts (AT) expression by dietary ARA and DHA, within the physiological range ..
  35. ncbi Intermediate levels of neuronal palmitoyl-protein Delta-9 desaturase in heterozygotes for murine Batten disease
    Srinivas B Narayan
    Department of Pathology and Laboratory Medicine, The Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Mol Genet Metab 93:89-91. 2008
    ..This is the first report of a heterozygous abnormality in Batten disease and provides important confirmation that this is the function of the CLN3 protein in neuronal tissues...
  36. doi Preliminary safety assessment of a membrane-bound delta 9 desaturase candidate protein for transgenic oilseed crops
    Krishna M Madduri
    Dow AgroSciences LLC, 9330 Zionsville Road, IN 46268, USA
    Food Chem Toxicol 50:3776-84. 2012
    A gene encoding delta 9 desaturase (D9DS), an integral membrane protein, is being considered for incorporation into oilseed crops to reduce saturated fatty acids and thus improve human nutritional value...
  37. ncbi Modulation of conjugated linoleic acid-induced loss of chicken egg hatchability by dietary soybean oil
    E Muma
    Department of Animal Science, University of Helsinki, Helsinki, Finland
    Poult Sci 85:712-20. 2006
    ..Increased incorporation of dietary linoleic and linolenic acids might have compensated for the reduced levels of palmitoleic and oleic acid, thus allowing for the improvement in hatchability...
  38. doi Conjugated linoleic acid differentially regulates fat deposition in backfat and longissimus muscle of finishing pigs
    Z Y Jiang
    Guangdong Public Laboratory of Animal Breeding and Nutrition, Ministry of Agriculture Key Laboratory of Animal Nutrition and Feed Science South China, Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou, PR China
    J Anim Sci 88:1694-705. 2010
    ..These data indicate that dietary CLA regulates fat deposition by affecting adipocyte proliferation, adipocyte differentiation, gene expression, and key metabolic enzymes of lipid metabolism...
  39. doi Dimethyl acetals, an indirect marker of the endogenous antioxidant plasmalogen level, are reduced in blood lipids of Sudanese pre-eclamptic subjects whose background diet is high in carbohydrate
    A A Bueno
    Institute of Brain Chemistry and Human Nutrition, London Metropolitan University, UK
    J Obstet Gynaecol 32:241-6. 2012
    ..pre-eclampsia is associated with oxidative stress and enhanced activity of the microsomal enzyme stearyl-CoA desaturase (delta 9 desaturase), as assessed by palmitic/palmitoleic (C16:0/C16:n-1) and stearic/oleic (C18/C18:1n-9) ratios.
  40. doi Genetic variation in polyunsaturated fatty acid metabolism and its potential relevance for human development and health
    Claudia Glaser
    Division of Metabolic and Nutritional Medicine, Dr von Hauner Children s Hospital, University of Munich Medical Center, Lindwurmstrasse 4, Munich, Germany
    Matern Child Nutr 7:27-40. 2011
    ....
  41. pmc Dietary long-chain polyunsaturated fatty acids upregulate expression of FADS3 transcripts
    Holly T Reardon
    Division of Nutritional Sciences, Cornell University, Ithaca, New York, USA
    Prostaglandins Leukot Essent Fatty Acids 88:15-9. 2013
    ..b>FADS3 is a putative desaturase due to its sequence similarity with FADS1 and FADS2, but its function is unknown...
  42. pmc In vivo inactivation of the mycobacterial integral membrane stearoyl coenzyme A desaturase DesA3 by a C-terminus-specific degradation process
    Yong Chang
    Department of Biochemistry, University of Wisconsin Madison, 433 Babcock Drive, Madison, Wisconsin 53706 1549, USA
    J Bacteriol 190:6686-96. 2008
    ..Among these, an annotation is known for less than half, underscoring a general lack of understanding of proteins that have only temporal existence in a cell...
  43. pmc Systemic down-regulation of delta-9 desaturase promotes muscle oxidative metabolism and accelerates muscle function recovery following nerve injury
    Ghulam Hussain
    INSERM, U1118, Mécanismes Centraux et Péripheriques de la Neurodégénérescence, Strasbourg, France
    PLoS ONE 8:e64525. 2013
    ..Overall, these findings provide evidence for a new role of SCD1 in modulating the restorative potential of skeletal muscles...
  44. pmc The role of fatty acid desaturases in epidermal metabolism
    Harini Sampath
    Center for Research on Occupational and Environmental Toxicology Oregon Health and Science University Portland, OR USA
    Dermatoendocrinol 3:62-4. 2011
    ..This review will focus on the role of fatty acid desaturases in maintaining epidermal metabolism...
  45. pmc Conversion of t11t13 CLA into c9t11 CLA in Caco-2 cells and inhibition by sterculic oil
    Anne Catherine Schneider
    Institut des Sciences de la Vie, Universite Catholique de Louvain, Louvain la Neuve, Belgium
    PLoS ONE 7:e32824. 2012
    ..This study aimed at investigating to which extent and by which route c9t11 CLA can be produced from another isomer of CLA, the t11t13 CLA that is structurally very similar to c9t11t13 CLnA, in Caco-2 cells...
  46. pmc Antimycobacterial Activity and Mechanism of Action of NAS-91
    Paul Gratraud
    Laboratoire de Dynamique des Interactions Membranaires Normales et Pathologiques, Université de Montpellier II et I, CNRS, UMR 5235, Case 107, Place Eugene Bataillon, 34095 Montpellier Cedex 05, France
    Antimicrob Agents Chemother 52:1162-6. 2008
    ..The development of a cell-free assay for Delta 9-desaturase activity allowed direct demonstration of the inhibition of oleic acid biosynthesis by these compounds...
  47. ncbi Direct desaturation of free myristic acid by hen liver microsomal Delta9-desaturase without prior activation to myristoyl-CoA derivative
    Aziz C Awad
    Department of Food Science and Human Nutrition, Michigan State University, East Lansing, Michigan 48824 1224, USA
    J Agric Food Chem 52:3194-201. 2004
    ....
  48. ncbi Fatty acid profiles of milk and rumen digesta from cows fed fish oil, extruded soybeans or their blend
    A A AbuGhazaleh
    Dairy Science Department, South Dakota State University, Brookings 57007 0647, USA
    J Dairy Sci 85:2266-76. 2002
    ....
  49. ncbi Mechanism of fatty acid desaturation: a bioorganic perspective
    B Behrouzian
    Department of Chemistry, Carleton University, Ottawa Carleton Chemistry Institute, 1125 Colonel By Drive, Ottawa, Ont, Canada K1S 5B6
    Prostaglandins Leukot Essent Fatty Acids 68:107-12. 2003
    ..These results point to a common active site architecture which is highly conserved among a wide range of membranous desaturases...
  50. ncbi Maintenance and regulation of mRNA stability of the Saccharomyces cerevisiae OLE1 gene requires multiple elements within the transcript that act through translation-independent mechanisms
    Muralikrishna Vemula
    Division of Life Sciences, Department of Cell Biology and Neuroscience, Rutgers University, Nelson Laboratories, Piscataway, New Jersey 08854, USA
    J Biol Chem 278:45269-79. 2003
    ....
  51. ncbi In vitro thermogenesis and phospholipid fatty acid composition of brown adipose tissue in fasted and refed rats
    S K Saha
    Department of Physiology I, Asahikawa Medical College School of Medicine, Asahikawa, 078 8510, Japan
    Jpn J Physiol 49:345-52. 1999
    ..These results indicate that the modification of phospholipid fatty acid composition, especially the modification of n-3 polyunsaturated fatty acid DHA, and membrane fluidity are related to BAT thermoregulation in fasted and refed rats...
  52. ncbi A stearoyl-CoA-specific Delta 9 fatty acid desaturase from the basidiomycete Lentinula edodes
    Hiromichi Sakai
    Department of Life Science, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Kanagawa, Japan
    Biosci Biotechnol Biochem 67:2431-7. 2003
    A gene encoding a Delta 9 fatty acid desaturase (Delta 9-desaturase) was isolated from L. edodes. The open reading frame of this gene (named Le-FAD1) consisted of 1416 bp...
  53. ncbi Fluorescence anisotropy studies of enzyme-substrate complex formation in stearoyl-ACP desaturase
    Jeffrey A Haas
    Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    Biochemistry 41:14472-81. 2002
    ..These results indicate that acyl chain length selectivity derives in major part from partition of the enzyme-substrate complex between substrate release and subsequent steps in catalysis...
  54. ncbi Transcriptional co-regulation of Saccharomyces cerevisiae alcohol acetyltransferase gene, ATF1 and delta-9 fatty acid desaturase gene, OLE1 by unsaturated fatty acids
    D Fujiwara
    Central Laboratories for Key Technology, Kirin Brewery Co Ltd, Kanagawa, Japan
    Yeast 14:711-21. 1998
    ..These results suggested that ATF1 transcription was co-regulated by the same mechanism as the OLE1 gene and that unsaturated fatty acids and oxygen repressed the ATF1 transcript by a different regulation pathway...
  55. ncbi Desaturation, chain scission, and register-shift of oxygen-substituted fatty acids during reaction with stearoyl-ACP desaturase
    Corina E Rogge
    Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin, 433 Babcock Drive, Madison, WI 53706, USA
    Biochemistry 41:10141-8. 2002
    ..Possible mechanisms of the acyl chain scission and implications of these results for the desaturation mechanism are considered...
  56. ncbi Conjugated linoleic acid differentially modifies fatty acid composition in subcellular fractions of muscle and adipose tissue but not adiposity of postweaning pigs
    Scott R Demaree
    Department of Animal Science, Texas A and M University, College Station, TX 77843, USA
    J Nutr 132:3272-9. 2002
    ..Thus, in spite of marked effects on fatty acid composition and the Delta(9) desaturase index, CLA had no effect on adiposity in early weaned piglets fed high fat diets...
  57. ncbi Expression and regulation of the SCD2 desaturase in the rat ovary
    Celine Moreau
    Unite de Physiologie de la Reproduction et des Comportements, Institut National de la Recherche Agronomique, 37380 Nouzilly, France
    Biol Reprod 74:75-87. 2006
    ..Western blot analyses the mRNA and protein expression of SCD2 (stearoyl-coenzyme A desaturase 2; also named delta 9 desaturase) in rat ovary...
  58. ncbi Response of the Pacific oyster Crassostrea gigas to hypoxia exposure under experimental conditions
    Elise David
    Laboratoire des Sciences de l Environnement Marin LEMAR, Institut Universitaire Europeen de la Mer, Universite de Bretagne Occidentale, Plouzane, France
    FEBS J 272:5635-52. 2005
    ..This study contributes to the characterization of many potential genetic markers that could be used in future environmental monitoring, and could lead to explore new mechanisms of stress tolerance in marine mollusc species...
  59. ncbi Alzheimer's disease through the eye of a mouse. Acceptance lecture for the 2001 Gayle A. Olson and Richard D. Olson prize
    John E Morley
    Geriatric Research, Education, and Clinical Center GRECC, VA Medical Center, St Louis, MO, USA
    Peptides 23:589-99. 2002
    ..This decreased cholinergic activity results in a decreased ability of the P8 mouse to learn and retain new information...
  60. pmc Comparison of different DNA-based methods for molecular typing of Histoplasma capsulatum
    Mauro de Medeiros Muniz
    Setor de Imunodiagnóstico do Laboratório de Micologia do Instituto de Pesquisa Clínica Evandro Chagas, Fundacao Oswaldo Cruz, Av Brasil 4365, Manguinhos, Rio de Janeiro 21045 900, Brazil
    Appl Environ Microbiol 76:4438-47. 2010
    ....
  61. pmc Saturated fatty acid metabolism is key link between cell division, cancer, and senescence in cellular and whole organism aging
    Judith H Ford
    Rural health and community engagement, University of South Australia, GPO Box 2471, Adelaide 5001, Australia
    Age (Dordr) 32:231-7. 2010
    ..Healthy longevity is likely to be most enhanced by factors that actively suppress excessive cell division...
  62. doi A comparison between Holstein-Friesian and Jersey dairy cows and their F(1) hybrid on milk fatty acid composition under grazing conditions
    R A Palladino
    School of Agriculture, Food Science and Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland
    J Dairy Sci 93:2176-84. 2010
    ..In conclusion, there was little evidence for either breed or beneficial heterotic effects on milk FA content with human health-promoting potential, though significant within-breed, interanimal variation was observed...
  63. pmc Genetic determinants of circulating sphingolipid concentrations in European populations
    Andrew A Hicks
    Institute of Genetic Medicine, European Academy Bozen Bolzano EURAC, Bolzano, Italy
    PLoS Genet 5:e1000672. 2009
    ..Variants in 3 loci (ATP10D, FADS3, and SPTLC3) associate with MI in a series of three German MI studies...
  64. doi Fish oil in feeds for entire male and female pigs: changes in muscle fatty acid composition and stability of sensory quality
    E Hallenstvedt
    Felleskjøpet Fôrutvikling, Bromstadveien 57, N 7005 Trondheim, Norway
    Meat Sci 85:182-90. 2010
    ..The results suggest levels of dietary fish oil up to 0.5% produce a healthier meat fatty acid composition, without negative effects on sensory attributes, even in long-termed stored belly...
  65. doi A multiplexed cell assay in HepG2 cells for the identification of delta-5, delta-6, and delta-9 desaturase and elongase inhibitors
    Lei Zhang
    Merck Frosst Center for Therapeutic Research, Montreal, Canada
    J Biomol Screen 15:169-76. 2010
    ..1 microM and 0.9 microM, respectively. This medium-throughput cell assay provides an efficient tool in the identification of specific desaturase and elongase inhibitors...
  66. ncbi The membrane proteins, Spt23p and Mga2p, play distinct roles in the activation of Saccharomyces cerevisiae OLE1 gene expression. Fatty acid-mediated regulation of Mga2p activity is independent of its proteolytic processing into a soluble transcription act
    R Chellappa
    Division of Life Sciences and the Bureau of Biological Research, Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, New Jersey 08854, USA
    J Biol Chem 276:43548-56. 2001
    ..The fatty acid repression of transcription under those conditions is attenuated by Spt23Deltatm, however, suggesting that the two proteins may interact to modulate OLE1 gene expression...
  67. ncbi The role of polyunsaturated fatty acids in restoring the aging neuronal membrane
    Shlomo Yehuda
    Psychopharmacology Laboratory, Department of Psychology, Bar Ilan University, Ramat Gan 52900, Israel
    Neurobiol Aging 23:843-53. 2002
    ..A central focus of this review is that a specific ratio of n-3/n-6 PUFA can restore many of these age-related effects...
  68. doi Lower estimates of delta-5 desaturase and elongase activity are related to adverse profiles for several metabolic risk factors in young Japanese women
    Kentaro Murakami
    Department of Social and Preventive Epidemiology, School of Public Health, The University of Tokyo, Tokyo 113 0033, Japan
    Nutr Res 28:816-24. 2008
    ....
  69. doi Flaxseed supplementation improves fatty acid profile of cow milk
    M Caroprese
    Dipartimento PRIME, Universita di Foggia, Via Napoli 25, 71100 Foggia, Italy
    J Dairy Sci 93:2580-8. 2010
    ..In conclusion, flaxseed supplementation improves composition and nutritional properties of milk from cows milked during times of high ambient temperature...
  70. ncbi Dietary docosahexaenoic acid affects stearic acid desaturation in spontaneously hypertensive rats
    M M Engler
    Laboratory of Cardiovascular Physiology, Department of Physiological Nursing, University of California, San Francisco 94143 0610, USA
    Lipids 35:1011-5. 2000
    ..The alterations in fatty acid composition and metabolism may contribute to the antihypertensive effect of DHA previously reported...
  71. pmc Manipulation of body fat composition with sterculic acid can inhibit mammary carcinomas in vivo
    D E Khoo
    Academic Department of Surgery, Royal Free Hospital, London, UK
    Br J Cancer 63:97-101. 1991
    ..001). A rise in the stearic:oleic acid ratio of tumours was observed in rats treated for only 16 days with sterculic acid. Manipulation of the tissue stearic:oleic acid ratio inhibits transplanted mammary tumour growth in rats...
  72. ncbi Prenatal and postnatal transfer of fatty acids from mother to pup in the hooded seal
    S J Iverson
    Canadian Institute of Fisheries Technology, Technical University of Nova Scotia, Halifax
    J Comp Physiol B 165:1-12. 1995
    ..Ingested fatty acids were deposited directly and without modification into the blubber of pups, and by 4 days the fatty acid composition of pup blubber was virtually identical to that of the milk consumed...
  73. ncbi A novel cytochrome b5-like domain is linked to the carboxyl terminus of the Saccharomyces cerevisiae delta-9 fatty acid desaturase
    A G Mitchell
    Department of Biological Sciences, Rutgers University, Nelson Laboratories, Piscataway, New Jersey 08855 1059, USA
    J Biol Chem 270:29766-72. 1995
    ....
  74. ncbi A temperature-sensitive strain of Histoplasma capsulatum has an altered delta 9-fatty acid desaturase gene
    S Gargano
    International Institute of Genetics and Biophysics, CNR, Naples, Italy
    Lipids 30:899-906. 1995
    ..The differential expression of delta 9-desaturase genes is discussed in relationship to differences in thermosensitivity in the fungal isolates and in regulating the level of expression of heat shock genes...
  75. ncbi Fatty acid-responsive control of mRNA stability. Unsaturated fatty acid-induced degradation of the Saccharomyces OLE1 transcript
    C I Gonzalez
    Department of Biological Sciences and the Bureau of Biological Research, Nelson Laboratories, Piscataway, New Jersey 08855 1059, USA
    J Biol Chem 271:25801-9. 1996
    ....
  76. ncbi Fah1p, a Saccharomyces cerevisiae cytochrome b5 fusion protein, and its Arabidopsis thaliana homolog that lacks the cytochrome b5 domain both function in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids
    A G Mitchell
    Department of Biological Sciences and the Bureau of Biological Research, Rutgers University, Nelson Laboratories, P O Box 1059, Piscataway, New Jersey 08855 1059, USA
    J Biol Chem 272:28281-8. 1997
    ....
  77. pmc Degradation of hepatic stearyl CoA delta 9-desaturase
    J Ozols
    Department of Biochemistry, University of Connecticut Health Center, Farmington 06030, USA
    Mol Biol Cell 8:2281-90. 1997
    ....
  78. doi Association analyses of single nucleotide polymorphisms in bovine stearoyl-CoA desaturase and fatty acid synthase genes with fatty acid composition in commercial cross-bred beef steers
    C Li
    Agriculture and Agri Food Canada, Lacombe Research Centre, 6000 C and E Trail, Lacombe, Alberta, Canada
    Anim Genet 43:93-7. 2012
    ..05). These results further suggest that SCD and FASN are strong candidate genes influencing fatty acid composition in beef cattle...
  79. pmc The polypyrimidine tract binding protein regulates desaturase alternative splicing and PUFA composition
    Holly T Reardon
    Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA
    J Lipid Res 52:2279-86. 2011
    ..In HepG2 cells, PTB knockdown modulated alternative splicing of FADS2, as well as FADS3, a putative desaturase of unknown function...
  80. doi Plasma fatty acids profile and estimated elongase and desaturases activities in Tunisian patients with the metabolic syndrome
    M M Sethom
    UR05 08 08 and LR99ES11, Department of Biochemistry, Rabta Hospital and Faculty of Medicine of Tunis, El Manar University, Tunis, Tunisia
    Prostaglandins Leukot Essent Fatty Acids 85:137-41. 2011
    ..Saturated and monounsaturated fatty acids levels and delta 9 desaturase activity were increased, but polyunsaturated fatty acids (PUFA) levels and delta 5 desaturase activity were ..
  81. ncbi cDNA cloning of acyl-CoA desaturase homologs in the silkworm, Bombyx mori
    T Yoshiga
    Laboratory of Molecular Entomology and Baculovirology, RIKEN, Hirosawa 2 1, Wako, Saitama, Japan
    Gene 246:339-45. 2000
    ..mori...
  82. pmc A delta 9 desaturase gene with a different substrate specificity is responsible for the cuticular diene hydrocarbon polymorphism in Drosophila melanogaster
    R Dallerac
    Universite Paris Sud, Unité Mixte de Recherche 8620, Neurobiologie et Apprentissage de la Mémoire et de la Communication, Orsa, France
    Proc Natl Acad Sci U S A 97:9449-54. 2000
    ..We suggest, therefore, that desat2 might play a control role in the biosynthesis of 5,9 HD hydrocarbons in Tai females and could explain the dienic hydrocarbon polymorphism in D. melanogaster...
  83. doi FADS gene polymorphisms in Koreans: association with ω6 polyunsaturated fatty acids in serum phospholipids, lipid peroxides, and coronary artery disease
    Jung Hyun Kwak
    Interdisciplinary Course of Science for Aging, Yonsei University, Seoul, South Korea
    Atherosclerosis 214:94-100. 2011
    ..We investigated the association of polymorphisms in FADS genes with polyunsaturated fatty acids (PUFAs) in serum phospholipids, lipid peroxides, and coronary artery disease (CAD) in Koreans...
  84. pmc FADS genetic variants and omega-6 polyunsaturated fatty acid metabolism in a homogeneous island population
    Rasika A Mathias
    Division of General Internal Medicine, The Johns Hopkins University, Baltimore, MD, USA
    J Lipid Res 51:2766-74. 2010
    ....
  85. doi Alterations in serum fatty acid concentrations and desaturase activities in Bietti crystalline dystrophy unaffected by CYP4V2 genotypes
    Timothy Y Y Lai
    Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong
    Invest Ophthalmol Vis Sci 51:1092-7. 2010
    ..To evaluate the serum fatty acid changes in Chinese patients with Bietti crystalline dystrophy (BCD) in association with CYP4V2 mutation...
  86. ncbi Yeast desaturases
    C E Martin
    Department of Cell Biology and Neuroscience, Bureau of Biological Research, Rutgers University, Nelson Laboratories, 604 Allison Road, Piscataway, NJ 08854, USA
    Biochem Soc Trans 30:1080-2. 2002
    ..Surprisingly, Mga2p also plays a critical role in controlling OLE1 mRNA stability, suggesting that there may be a functional linkage between OLE1 transcription and the regulation of OLE1 mRNA stability...
  87. pmc The fatty acid desaturase 3 gene encodes for different FADS3 protein isoforms in mammalian tissues
    Frederique Pedrono
    Laboratoire de Biochimie et Nutrition Humaine, USC INRA 2012, Agrocampus Ouest, Rennes, France
    J Lipid Res 51:472-9. 2010
    ..A third gene, named FADS3, has recently been identified but no functional role has yet been attributed to the putative FADS3 protein...
  88. doi Variation of Delta 9-desaturase activity in dairy cattle
    H Soyeurt
    Gembloux Agricultural University, Animal Science Unit, B 5030 Gembloux, Belgium
    J Dairy Sci 91:3211-24. 2008
    ..The positive genetic correlations observed between %MONO and the ratios of C14:1 cis-9 to C14:0 (0.72), C16:1 cis-9 to C16:0 (0.62), and C18:1 cis to C18:0 (0.97) showed that %MONO is linked to the Delta(9)-desaturase activity...
  89. ncbi Alterations in the oxidation products, antioxidant markers, antioxidant capacity and lipid patterns in plasma of patients affected by Papillon-Lefèvre syndrome
    Maurizio Battino
    Institute of Biochemistry, University of Ancona, Via Ranieri, 65, 60100 Ancona, Italy
    Free Radic Res 37:603-9. 2003
    ..This finding would support the hypothesisby Gutteridge and co-workers (Free Radic. Res. 1998, 28: 109-114) that conditions exist in which some forms of oxidative stress can lead to changes characteristic of EFAD...
  90. doi Cobalt supplied per os reduces the mammary Delta9-desaturase index of bovine milk
    O Taugbøl
    Department of Animal and Aquaculture Sciences, Norwegian University of Life Sciences, 1432 As, Norway
    J Anim Sci 86:3062-8. 2008
    ..On the basis of these results, we concluded that Co given per os decreased the Delta(9)-desaturase indices of bovine milk...
  91. doi Role of stearoyl-coenzyme A desaturase in regulating lipid metabolism
    Matthew T Flowers
    Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706, USA
    Curr Opin Lipidol 19:248-56. 2008
    ..This review evaluates the latest advances in our understanding of the pivotal role of stearoyl-coenzyme A desaturase 1 in health and disease...
  92. ncbi Effects of dietary cis 9, trans 11-18:2, trans 10, cis 12-18:2, or vaccenic acid (trans 11-18:1) during lactation on body composition, tissue fatty acid profiles, and litter growth in mice
    Juan J Loor
    Dairy Science Department, Virginia Tech Unicersity, Blacksburg, 24061 0315, USA
    Br J Nutr 90:1039-48. 2003
    ..Although these effects need to be confirmed in lactating women, the results suggest that the consumption of supplements containing t10, c12-18:2 should be avoided during the nursing period...
  93. ncbi Endogenous synthesis of cis-9, trans-11 conjugated linoleic acid in dairy cows fed fresh pasture
    J K Kay
    Dexcel Ltd, Private Bag 3221, Hamilton, New Zealand
    J Dairy Sci 87:369-78. 2004
    ..However, the failure of plant oil supplements to increase the concentration of cis-9, trans-11 CLA in milk fat from pasture-fed cows requires further investigation...
  94. ncbi Lou/C obesity-resistant rat exhibits hyperactivity, hypermetabolism, alterations in white adipose tissue cellularity, and lipid tissue profiles
    Christophe Soulage
    Universite de Lyon 1, Lyon, France
    Endocrinology 149:615-25. 2008
    ....
  95. ncbi Dietary conjugated linoleic acid decreases adipocyte size and favorably modifies adipokine status and insulin sensitivity in obese, insulin-resistant rats
    Amy Noto
    Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, MB, Canada
    Metabolism 56:1601-11. 2007
    ..In conclusion, CLA reduced adipocyte size and favorably modified adipokine status and insulin sensitivity in fa/fa Zucker rats...
  96. ncbi A coupled dinuclear iron cluster that is perturbed by substrate binding in myo-inositol oxygenase
    Gang Xing
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Biochemistry 45:5393-401. 2006
    ....
  97. ncbi N-3 long chain polyunsaturated fatty acids: a nutritional tool to prevent insulin resistance associated to type 2 diabetes and obesity?
    Jacques Delarue
    EA 948 Oxylipides, Faculte de Medecine, 29200 Brest, France
    Reprod Nutr Dev 44:289-99. 2004
    ..This last effect results on the one hand, from a decreased expression of lipogenesis enzymes and of delta 9 desaturase (via a depleting effect on sterol response element binding protein 1c (SREBP-1c)...
  98. ncbi Characterization of HSCD5, a novel human stearoyl-CoA desaturase unique to primates
    Jian Wang
    Cardiovascular Division, Lilly Research Labs, Eli Lilly and Company, DC 0343, Indianapolis, IN 46285, USA
    Biochem Biophys Res Commun 332:735-42. 2005
    ..Microsome fractions prepared from hSCD1 and hSCD5 transfected cells displayed similar delta 9 desaturase activity...
  99. ncbi Regulation of desaturase expression in HL60 cells
    J E Slagsvold
    Department of Medical Biochemistry, St Olav s Hospital HF, Trondheim, Norway
    Scand J Clin Lab Invest 67:632-42. 2007
    The expression of delta 5 desaturase (D5D), delta 6 desaturase (D6D) and delta 9 desaturase (D9D) was determined by RT-PCR in the human promyelocytic cell line HL60...
  100. ncbi Stereochemistry of Delta4 dehydrogenation catalyzed by an ivy (Hedera helix) Delta9 desaturase homolog
    Amy E Tremblay
    Department of Chemistry, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario, Canada
    Org Biomol Chem 5:1270-5. 2007
    ..These data show that despite the difference in regioselectivity between the two enzymes, the stereochemistry of hydrogen removal is conserved...
  101. ncbi Regulation of long chain unsaturated fatty acid synthesis in yeast
    Charles E Martin
    Rutgers University, Department of Cell Biology and Neuroscience, Nelson Laboratories, 604 Allison Road, Piscataway, NJ 08854 8082, USA
    Biochim Biophys Acta 1771:271-85. 2007
    ..OLE1 is regulated through Spt23p and Mga2p by multiple systems that control its transcription and mRNA stability in response to diverse stimuli that include nutrient fatty acids, carbon source, metal ions and the availability of oxygen...

Research Grants50

  1. IRON OXO CLUSTERS AND FATTY ACID DESATURATION
    Brian Fox; Fiscal Year: 1999
    ..Both of these outcomes will help to further define the principles which govern O2-activation by the proteins containing iron-oxo clusters. ..
  2. Synthetic Models and Spectroscopy of Metal-Oxo Proteins
    Lawrence Que; Fiscal Year: 2006
    ..coli ferritins as well as intermediates O, P, Q, and T in the methane monooxygenase cycle. These biophysical experiments dovetail well with the efforts to generate synthetic models for these enzyme intermediates. ..
  3. Genetic modification of PUFA biosynthesis and CHD
    Ana Baylin; Fiscal Year: 2006
    ..The proposed genes include: fatty acid desaturase (FADS)2 (delta6-desaturase), FADS1 (delta5-desaturase), and FADS3, ELOVL-1,2,3,4,5,6,7 (7 elongase genes), PPAR-alpha, and SREBP-1c...
  4. Genetic modification of PUFA biosynthesis and CHD
    Ana Baylin; Fiscal Year: 2007
    ..The proposed genes include: fatty acid desaturase (FADS)2 (delta6-desaturase), FADS1 (delta5-desaturase), and FADS3, ELOVL-1,2,3,4,5,6,7 (7 elongase genes), PPAR-alpha, and SREBP-1c...
  5. REGULATION OF FATTY ACID METABOLISM
    Charles Martin; Fiscal Year: 2002
    ..abstract_text> ..
  6. REGULATION OF FATTY ACID METABOLISM
    Charles Martin; Fiscal Year: 1992
    ....
  7. Molecular and Cellular Biology of Lipids
    Charles Martin; Fiscal Year: 2007
    ..Proper facilities are available to accommodate handicapped individuals who will be considered equally in the selection of attendees and speakers. ..
  8. GCx(py)GCC-IRMS for Isotope Metabolomics
    JAMES T BRENNA; Fiscal Year: 2010
    ..Applications to polyunsaturated fatty acid and lactic acid metabolism are pro- posed. ..
  9. Gas phase derivatization for lipidomic MS analysis
    JAMES BRENNA; Fiscal Year: 2007
    ....
  10. PRECISE ISOTOPE RATIO CHROMATOGRAPHY AND STABLE TRACERS
    JAMES BRENNA; Fiscal Year: 2004
    ..The successful accomplishment of these plans will yield new tools and experimental approaches for investigation of the impact of developmental factors and recent physiological history on development of chronic disease. ..
  11. Prostate Cancer: A Mouse Model Testing 15-Lipoxygenase-1
    Uddhav Kelavkar; Fiscal Year: 2004
    ..abstract_text> ..
  12. LCPUFA Status and Birth Outcome in India
    JAMES BRENNA; Fiscal Year: 2007
    ..Positive results would justify an intervention studies to include LCPUFA in the diets of pregnant women in developed and developing countries. ..
  13. Lipidomics Session ISSFAL 2006
    JAMES BRENNA; Fiscal Year: 2006
    ..ISSFAL 2006 is expected to be among the most important international lipid metabolism conferences of the year, and a lipidomics symposium is timely given the increasing progress in this area. ..
  14. PRECISE ISOTOPE RATIO CHROMATOGRAPHY AND STABLE TRACERS
    JAMES BRENNA; Fiscal Year: 1993
    ..The computer program CONSAAM will be used for biokinetic modeling of fatty acid transport and transformation as components of specific lipid classes in lipoproteins and plasma borne cell types...
  15. PRECISE ISOTOPE RATIO CHROMATOGRAPHY AND STABLE TRACERS
    JAMES BRENNA; Fiscal Year: 2000
    ..Finally, continued studies of fatty acid metabolism in humans, particularly transformations of fatty acids into other bioactive molecules, allows timely evaluation and refinement of developed instruments and methods. ..
  16. DIETARY ESSENTIAL FATTY ACID ACCUMULATION IN RETINA
    JAMES BRENNA; Fiscal Year: 2002
    ..Sub-normal development will be directly revealed via functional tests to assess the impact of low omega-3 fatty acid status on develop of vision acid status on development of vision and related health parameters. ..