FADS1

Summary

Gene Symbol: FADS1
Description: fatty acid desaturase 1
Alias: D5D, FADS6, FADSD5, LLCDL1, TU12, fatty acid desaturase 1, delta(5) desaturase, delta-5 fatty acid desaturase, linoleoyl-CoA desaturase (delta-6-desaturase)-like 1
Species: human
Products:     FADS1

Top Publications

  1. Nakayama K, Bayasgalan T, Tazoe F, Yanagisawa Y, Gotoh T, Yamanaka K, et al. A single nucleotide polymorphism in the FADS1/FADS2 gene is associated with plasma lipid profiles in two genetically similar Asian ethnic groups with distinctive differences in lifestyle. Hum Genet. 2010;127:685-90 pubmed publisher
    Recent genome-wide association studies (GWASs) showed that single nucleotide polymorphisms (SNPs) in FADS1/FADS2 were associated with plasma lipid concentrations in populations with European ancestry...
  2. Xie L, Innis S. Association of fatty acid desaturase gene polymorphisms with blood lipid essential fatty acids and perinatal depression among Canadian women: a pilot study. J Nutrigenet Nutrigenomics. 2009;2:243-50 pubmed publisher
    The FADS1/FADS2 gene cluster encodes Delta-5 and Delta-6 desaturase, rate-limiting enzymes in metabolism of linoleic (LA) to arachidonic (ARA) and alpha-linolenic to eicosapentaenoic and docosahexaenoic acid (DHA)...
  3. Kröger J, Zietemann V, Enzenbach C, Weikert C, Jansen E, Döring F, et al. Erythrocyte membrane phospholipid fatty acids, desaturase activity, and dietary fatty acids in relation to risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study. Am J Clin Nutr. 2011;93:127-42 pubmed publisher
    ..The long-term role of fatty acids (FAs) in the cause of diabetes remains largely unclear...
  4. Malerba G, Schaeffer L, Xumerle L, Klopp N, Trabetti E, Biscuola M, et al. SNPs of the FADS gene cluster are associated with polyunsaturated fatty acids in a cohort of patients with cardiovascular disease. Lipids. 2008;43:289-99 pubmed publisher
    Polymorphisms of the human Delta-5 (FADS1) and Delta-6 (FADS2) desaturase genes have been recently described to be associated with the level of several long-chain n-3 and n-6 polyunsaturated fatty acids (PUFAs) in serum phospholipids...
  5. Rzehak P, Thijs C, Standl M, Mommers M, Glaser C, Jansen E, et al. Variants of the FADS1 FADS2 gene cluster, blood levels of polyunsaturated fatty acids and eczema in children within the first 2 years of life. PLoS ONE. 2010;5:e13261 pubmed publisher
    Association of genetic-variants in the FADS1-FADS2-gene-cluster with fatty-acid-composition in blood of adult-populations is well established. We analyze this genetic-association in two children-cohort-studies...
  6. Al Hilal M, AlSaleh A, Maniou Z, Lewis F, Hall W, Sanders T, et al. Genetic variation at the FADS1-FADS2 gene locus influences delta-5 desaturase activity and LC-PUFA proportions after fish oil supplement. J Lipid Res. 2013;54:542-51 pubmed publisher
    ..subjects (n = 310), genotypes of single nucleotide polymorphisms (SNPs) rs174537, rs174561, and rs3834458 in the FADS1-FADS2 gene cluster were strongly associated with proportions of LC-PUFAs and desaturase activities estimated in ..
  7. Merino D, Ma D, Mutch D. Genetic variation in lipid desaturases and its impact on the development of human disease. Lipids Health Dis. 2010;9:63 pubmed publisher
    ..This review will highlight the current state-of-knowledge regarding three desaturases (Scd-1, Fads1 and Fads2) and their potential roles in disease onset and development...
  8. Cho H, Nakamura M, Clarke S. Cloning, expression, and fatty acid regulation of the human delta-5 desaturase. J Biol Chem. 1999;274:37335-9 pubmed
    ..Finally, a BLAST and Genemap search of the human genome revealed that the Delta-5 and Delta-6 desaturase genes reside in reverse orientation on chromosome 11 and that they are separated by <11,000 base pairs. ..
  9. Dumont J, Huybrechts I, Spinneker A, Gottrand F, Grammatikaki E, Bevilacqua N, et al. FADS1 genetic variability interacts with dietary ?-linolenic acid intake to affect serum non-HDL-cholesterol concentrations in European adolescents. J Nutr. 2011;141:1247-53 pubmed publisher
    Two rate-limiting enzymes in PUFA biosynthesis, ?5- and ?6-desaturases, are encoded by the FADS1 and FADS2 genes, respectively...

More Information

Publications87

  1. Plaisier C, Horvath S, Huertas Vazquez A, Cruz Bautista I, Herrera M, Tusie Luna T, et al. A systems genetics approach implicates USF1, FADS3, and other causal candidate genes for familial combined hyperlipidemia. PLoS Genet. 2009;5:e1000642 pubmed publisher
    ..We then provide evidence from two independent datasets supporting FADS3 as a causal gene for FCHL and elevated TGs in Mexicans. ..
  2. Eijgelsheim M, Newton Cheh C, Sotoodehnia N, de Bakker P, Müller M, Morrison A, et al. Genome-wide association analysis identifies multiple loci related to resting heart rate. Hum Mol Genet. 2010;19:3885-94 pubmed publisher
    ..c12orf67, BCAT1, LRMP and CASC1; 6q22 near SLC35F1, PLN and c6orf204; 7q22 near SLC12A9 and UfSp1; and 11q12 near FADS1. Associations at 6q22 400 kb away from GJA1, at 14q12 MYH6 and at 1q32 near CD34 identified in previously ..
  3. Schaeffer L, Gohlke H, Müller M, Heid I, Palmer L, Kompauer I, et al. Common genetic variants of the FADS1 FADS2 gene cluster and their reconstructed haplotypes are associated with the fatty acid composition in phospholipids. Hum Mol Genet. 2006;15:1745-56 pubmed
    ..We report strong associations between variants in the human delta-5 and delta-6 desaturase genes FADS1 FADS2 and fatty acid composition in serum phospholipids...
  4. Marquardt A, Stohr H, White K, Weber B. cDNA cloning, genomic structure, and chromosomal localization of three members of the human fatty acid desaturase family. Genomics. 2000;66:175-83 pubmed
    ..4-Mb region in 11q12-q13.1, full-length fatty acid desaturase-1 (FADS1) and fatty acid desaturase-2 (FADS2) transcripts were obtained by EST sequence assembly...
  5. Mathias R, Vergara C, Gao L, Rafaels N, Hand T, Campbell M, et al. FADS genetic variants and omega-6 polyunsaturated fatty acid metabolism in a homogeneous island population. J Lipid Res. 2010;51:2766-74 pubmed publisher
    ..of 22 PUFAs were determined by gas chromatography, of which ten fatty acids and five ratios defining FADS1 and FADS2 activity were tested for genetic association against 16 single nucleotide polymorphisms (SNP) in 224 ..
  6. Koletzko B, Lattka E, Zeilinger S, Illig T, Steer C. Genetic variants of the fatty acid desaturase gene cluster predict amounts of red blood cell docosahexaenoic and other polyunsaturated fatty acids in pregnant women: findings from the Avon Longitudinal Study of Parents and Children. Am J Clin Nutr. 2011;93:211-9 pubmed publisher
    ..Polymorphisms in the desaturase encoding genes FADS1 and FADS2 have been associated with several n-6 (omega-6) and n-3 (omega-3) FAs and especially with arachidonic ..
  7. Lu Y, Feskens E, Dollé M, Imholz S, Verschuren W, Muller M, et al. Dietary n-3 and n-6 polyunsaturated fatty acid intake interacts with FADS1 genetic variation to affect total and HDL-cholesterol concentrations in the Doetinchem Cohort Study. Am J Clin Nutr. 2010;92:258-65 pubmed publisher
    The delta-5 and delta-6 desaturases, encoded by the FADS1 and FADS2 genes, are rate-limiting enzymes in polyunsaturated fatty acid (PUFA) biosynthesis...
  8. Morales E, Bustamante M, Gonzalez J, Guxens M, Torrent M, Mendez M, et al. Genetic variants of the FADS gene cluster and ELOVL gene family, colostrums LC-PUFA levels, breastfeeding, and child cognition. PLoS ONE. 2011;6:e17181 pubmed publisher
    ..Children of mothers carrying genetic variants associated with lower FADS1 activity (regulating AA and EPA synthesis), higher FADS2 activity (regulating DHA synthesis), and with higher EPA/..
  9. Kwak J, Paik J, Kim O, Jang Y, Lee S, Ordovas J, et al. FADS gene polymorphisms in Koreans: association with ?6 polyunsaturated fatty acids in serum phospholipids, lipid peroxides, and coronary artery disease. Atherosclerosis. 2011;214:94-100 pubmed publisher
    ..study, CAD patients (n=756, 40-79 years) and healthy controls (n=890) were genotyped for rs174537 near FADS1 (FEN1 rs174537G>T), FADS2 (rs174575, rs2727270), and FADS3 (rs1000778)...
  10. Merino D, Johnston H, Clarke S, Roke K, Nielsen D, BADAWI A, et al. Polymorphisms in FADS1 and FADS2 alter desaturase activity in young Caucasian and Asian adults. Mol Genet Metab. 2011;103:171-8 pubmed publisher
    Recent evidence indicates that genetic variation in fatty acid desaturases 1 and 2 (FADS1 and FADS2) is associated with changes in plasma fatty acid profiles; however, the association with altered desaturase activity has not been ..
  11. Dupuis J, Langenberg C, Prokopenko I, Saxena R, Soranzo N, Jackson A, et al. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet. 2010;42:105-16 pubmed publisher
    ..These include nine loci newly associated with fasting glucose (in or near ADCY5, MADD, ADRA2A, CRY2, FADS1, GLIS3, SLC2A2, PROX1 and C2CD4B) and one influencing fasting insulin and HOMA-IR (near IGF1)...
  12. Illig T, Gieger C, Zhai G, Römisch Margl W, Wang Sattler R, Prehn C, et al. A genome-wide perspective of genetic variation in human metabolism. Nat Genet. 2010;42:137-41 pubmed publisher
    ..For eight out of nine replicated loci (FADS1, ELOVL2, ACADS, ACADM, ACADL, SPTLC3, ETFDH and SLC16A9), the genetic variant is located in or near genes encoding ..
  13. Lattka E, Illig T, Heinrich J, Koletzko B. Do FADS genotypes enhance our knowledge about fatty acid related phenotypes?. Clin Nutr. 2010;29:277-87 pubmed publisher
    ..have reported an association between single nucleotide polymorphisms (SNPs) in the two desaturase encoding genes (FADS1 and FADS2) and the concentration of omega-6 and omega-3 fatty acids...
  14. Lattka E, Illig T, Heinrich J, Koletzko B. FADS gene cluster polymorphisms: important modulators of fatty acid levels and their impact on atopic diseases. J Nutrigenet Nutrigenomics. 2009;2:119-28 pubmed publisher
    ..the last few years have revealed that single nucleotide polymorphisms (SNPs) in the 2 desaturase encoding genes (FADS1 and FADS2) are highly associated with the concentration of omega-6 and omega-3 fatty acids, showing that beside ..
  15. Tanaka T, Shen J, Abecasis G, Kisialiou A, Ordovas J, Guralnik J, et al. Genome-wide association study of plasma polyunsaturated fatty acids in the InCHIANTI Study. PLoS Genet. 2009;5:e1000338 pubmed publisher
    ..evidence for association was observed in a region of chromosome 11 that encodes three fatty acid desaturases (FADS1, FADS2, FADS3)...
  16. Xie L, Innis S. Genetic variants of the FADS1 FADS2 gene cluster are associated with altered (n-6) and (n-3) essential fatty acids in plasma and erythrocyte phospholipids in women during pregnancy and in breast milk during lactation. J Nutr. 2008;138:2222-8 pubmed publisher
    ..We determined if single nucleotide polymorphisms in FADS1 and FADS2 influence plasma phospholipid and erythrocyte ethanolamine phosphoglyceride (EPG) (n-6) and (n-3) fatty ..
  17. Martinelli N, Girelli D, Malerba G, Guarini P, Illig T, Trabetti E, et al. FADS genotypes and desaturase activity estimated by the ratio of arachidonic acid to linoleic acid are associated with inflammation and coronary artery disease. Am J Clin Nutr. 2008;88:941-9 pubmed
    The delta-5 and delta-6 desaturases, encoded by FADS1 and FADS2 genes, are key enzymes in polyunsaturated fatty acid (PUFA) metabolism that catalyze the conversion of linoleic acid (LA) into arachidonic acid (AA) and that of alpha-..
  18. Rzehak P, Heinrich J, Klopp N, Schaeffer L, Hoff S, Wolfram G, et al. Evidence for an association between genetic variants of the fatty acid desaturase 1 fatty acid desaturase 2 ( FADS1 FADS2) gene cluster and the fatty acid composition of erythrocyte membranes. Br J Nutr. 2009;101:20-6 pubmed publisher
    The present study gives further evidence for the recently found association between variants of the fatty acid desaturase 1 fatty acid desaturase 2 (FADS1 FADS2) gene cluster and PUFA in blood phospholipids and explores this association ..
  19. Roke K, Ralston J, Abdelmagid S, Nielsen D, BADAWI A, El Sohemy A, et al. Variation in the FADS1/2 gene cluster alters plasma n-6 PUFA and is weakly associated with hsCRP levels in healthy young adults. Prostaglandins Leukot Essent Fatty Acids. 2013;89:257-63 pubmed publisher
    Past research has reported that single nucleotide polymorphisms (SNPs) in fatty acid desaturase 1 and 2 (FADS1/2) can influence plasma fatty acid (FA) profiles...
  20. Standl M, Sausenthaler S, Lattka E, Koletzko S, Bauer C, Wichmann H, et al. FADS gene variants modulate the effect of dietary fatty acid intake on allergic diseases in children. Clin Exp Allergy. 2011;41:1757-66 pubmed publisher
    ..The aim of the current study was to assess the influence of FADS1 FADS2 gene cluster polymorphisms on the association between dietary fatty acid intake and atopic diseases and ..
  21. Lu Y, Vaarhorst A, Merry A, Dollé M, Hovenier R, Imholz S, et al. Markers of endogenous desaturase activity and risk of coronary heart disease in the CAREMA cohort study. PLoS ONE. 2012;7:e41681 pubmed publisher
    ..Therefore, the aim of this study was to investigate the relation between these ratios as well as genotypes of FADS1 rs174547 and CHD incidence...
  22. Gillingham L, Harding S, Rideout T, Yurkova N, Cunnane S, Eck P, et al. Dietary oils and FADS1-FADS2 genetic variants modulate [13C]?-linolenic acid metabolism and plasma fatty acid composition. Am J Clin Nutr. 2013;97:195-207 pubmed publisher
    ..dietary ?-linolenic acid (ALA) to omega-3 (n-3) long-chain fatty acids (FAs) is mediated through FA desaturases (FADS1-FADS2) and may be influenced by dietary FA composition...
  23. Bokor S, Dumont J, Spinneker A, Gonzalez Gross M, Nova E, Widhalm K, et al. Single nucleotide polymorphisms in the FADS gene cluster are associated with delta-5 and delta-6 desaturase activities estimated by serum fatty acid ratios. J Lipid Res. 2010;51:2325-33 pubmed publisher
    Genetic variability in the FADS1-FADS2 gene cluster [encoding delta-5 (D5D) and delta-6 (D6D) desaturases] has been associated with plasma long-chain PUFA (LCPUFA) and lipid levels in adults...
  24. Brookes K, Chen W, Xu X, Taylor E, Asherson P. Association of fatty acid desaturase genes with attention-deficit/hyperactivity disorder. Biol Psychiatry. 2006;60:1053-61 pubmed
    ..Two SNPs in the fatty acid desaturase 1 (FADS1) gene were nominally associated with ADHD only in the prenatal alcohol-exposed group of children; ..
  25. Gieger C, Geistlinger L, Altmaier E, Hrabe de Angelis M, Kronenberg F, Meitinger T, et al. Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum. PLoS Genet. 2008;4:e1000282 pubmed publisher
    ..We identified four genetic variants in genes coding for enzymes (FADS1, LIPC, SCAD, MCAD) where the corresponding metabolic phenotype (metabotype) clearly matches the biochemical ..
  26. Lattka E, Illig T, Koletzko B, Heinrich J. Genetic variants of the FADS1 FADS2 gene cluster as related to essential fatty acid metabolism. Curr Opin Lipidol. 2010;21:64-9 pubmed publisher
    ..Cloning of the coding sequences and chromosomal localization of the desaturase encoding genes fatty acid desaturase 1 and 2 (FADS1 and FADS2) opened the way for analyses of genetic factors as regulators of desaturase ..
  27. Glaser C, Heinrich J, Koletzko B. Role of FADS1 and FADS2 polymorphisms in polyunsaturated fatty acid metabolism. Metabolism. 2010;59:993-9 pubmed publisher
    ..Strong associations between variants in the human genes fatty acid desaturase 1 (FADS1, encoding Delta-5 desaturase) and fatty acid desaturase 2 (FADS2, encoding Delta-6 desaturase) and ..
  28. Molto Puigmarti C, Plat J, Mensink R, Muller A, Jansen E, Zeegers M, et al. FADS1 FADS2 gene variants modify the association between fish intake and the docosahexaenoic acid proportions in human milk. Am J Clin Nutr. 2010;91:1368-76 pubmed publisher
    The genes encoding Delta(5)- and Delta(6)-desaturases (FADS1 FADS2 gene cluster) were reported to be associated with n-3 (omega-3) and n-6 (omega-6) fatty acid proportions in human plasma, tissues, and milk...
  29. Rocha Rodrigues S, Rodríguez A, Gonçalves I, Moreira A, Maciel E, Santos S, et al. Impact of physical exercise on visceral adipose tissue fatty acid profile and inflammation in response to a high-fat diet regimen. Int J Biochem Cell Biol. 2017;87:114-124 pubmed publisher
    ..ET increased eWAT fatty acid desaturase 1 (FADS1) and elongase 5 (ELOVL5) protein content in both diet types...
  30. Fujita H, Hara K, Shojima N, Horikoshi M, Iwata M, Hirota Y, et al. Variations with modest effects have an important role in the genetic background of type 2 diabetes and diabetes-related traits. J Hum Genet. 2012;57:776-9 pubmed publisher
    ..rs340874 (PROX1), rs4607517 (GCK), rs2191349 (DGKB-TMEM195), rs7034200 (GLIS3), rs10885122 (ADRA2A), rs174550 (FADS1), rs11605924 (CRY2), rs10830963 (MTNR1B) and rs35767 (IGF1)...
  31. Zhang J, Qin X, Liang A, Kim E, Lawrence P, Park W, et al. Fads3 modulates docosahexaenoic acid in liver and brain. Prostaglandins Leukot Essent Fatty Acids. 2017;123:25-32 pubmed publisher
    Fatty acid desaturase 3 (FADS3) is the third member of the FADS gene cluster. FADS1 and FADS2 code for enzymes required for highly unsaturated fatty acid (HUFA) biosynthesis, but FADS3 function remains elusive...
  32. Schuchardt J, Kobe T, Witte V, Willers J, Gingrich A, Tesky V, et al. Genetic Variants of the FADS Gene Cluster Are Associated with Erythrocyte Membrane LC PUFA Levels in Patients with Mild Cognitive Impairment. J Nutr Health Aging. 2016;20:611-20 pubmed publisher
    ..12 single nucleotide polymorphisms (SNPs) of the FADS1, FADS2, and FADS3 gene clusters were genotyped in 111 MCI patients and evaluated associations with PUFA levels in ..
  33. Walle P, Takkunen M, Männistö V, Vaittinen M, Lankinen M, Kärjä V, et al. Fatty acid metabolism is altered in non-alcoholic steatohepatitis independent of obesity. Metabolism. 2016;65:655-66 pubmed publisher
    ..Accordingly, NASH was associated with higher hepatic mRNA expression of corresponding genes FADS1, FADS2 and SCD...
  34. Wang C, Qin N, Zhu M, Chen M, Xie K, Cheng Y, et al. Metabolome-wide association study identified the association between a circulating polyunsaturated fatty acids variant rs174548 and lung cancer. Carcinogenesis. 2017;38:1147-1154 pubmed publisher
    ..57, P = 1.68 × 10-3). Rs174548 was also found associated with FADS1 (the major fatty acid desaturase of identified PUFAs) expression in liver tissues...
  35. Lauritzen L, Sørensen L, Harsløf L, Ritz C, Stark K, Astrup A, et al. Mendelian randomization shows sex-specific associations between long-chain PUFA-related genotypes and cognitive performance in Danish schoolchildren. Am J Clin Nutr. 2017;106:88-95 pubmed publisher
    ..b>Design: Associations between selected FADS1/2 SNPs (rs1535, rs174448, and rs174468) and ELOVL5 rs2397142, whole-blood fatty acid composition, and ..
  36. Yang H, Wang R, Huang S, Huang C, Su K. Genetic polymorphisms of FADS1, FADS2, and FADS3 and fatty acid profiles in subjects received methadone maintenance therapy. Prostaglandins Leukot Essent Fatty Acids. 2017;: pubmed publisher
    ..89 MMT drug abusers and analyzed 3 tag single nucleotide polymorphisms (SNPs) from Fatty acid desaturases (FADS), FADS1, FADS2 and FADS3. The fatty acid profiles of erythrocyte membranes were analyzed based on genetic variations...
  37. Yary T, Voutilainen S, Tuomainen T, Ruusunen A, Nurmi T, Virtanen J. Serum n-6 polyunsaturated fatty acids, ?5- and ?6-desaturase activities, and risk of incident type 2 diabetes in men: the Kuopio Ischaemic Heart Disease Risk Factor Study. Am J Clin Nutr. 2016;103:1337-43 pubmed publisher
    ..the associations of serum n-6 PUFAs and activities of enzymes involved in PUFA metabolism, ?5 desaturase (D5D) and ?6 desaturase (D6D), with T2D risk to determine whether serum zinc concentrations could modify these ..
  38. Irvine N, Lillycrop K, Fielding B, Torrens C, Hanson M, Burdge G. Polyunsaturated fatty acid biosynthesis is involved in phenylephrine-mediated calcium release in vascular smooth muscle cells. Prostaglandins Leukot Essent Fatty Acids. 2015;101:31-9 pubmed publisher
    ..Murine VSM cells converted 18:2n-6 to longer chain PUFA including 22:5n-6. Δ6 (D6d) and Δ5 (D5d) desaturase, and elongase (Elovl) 5 were expressed...
  39. Gromovsky A, Schugar R, Brown A, Helsley R, Burrows A, Ferguson D, et al. ?-5 Fatty Acid Desaturase FADS1 Impacts Metabolic Disease by Balancing Proinflammatory and Proresolving Lipid Mediators. Arterioscler Thromb Vasc Biol. 2018;38:218-231 pubmed publisher
    Human genetic variants near the FADS (fatty acid desaturase) gene cluster (FADS1-2-3) are strongly associated with cardiometabolic traits including dyslipidemia, fatty liver, type 2 diabetes mellitus, and coronary artery ..
  40. Hellstrand S, Ericson U, Gullberg B, Hedblad B, Orho Melander M, Sonestedt E. Genetic variation in FADS1 has little effect on the association between dietary PUFA intake and cardiovascular disease. J Nutr. 2014;144:1356-63 pubmed publisher
    ..We examined whether the SNP rs174546 in FADS1 modifies the association between PUFA intakes and CVD risk...
  41. Maintinguer Norde M, Oki E, Ferreira Carioca A, Teixeira Damasceno N, Fisberg R, Lobo Marchioni D, et al. Influence of IL1B, IL6 and IL10 gene variants and plasma fatty acid interaction on metabolic syndrome risk in a cross-sectional population-based study. Clin Nutr. 2018;37:659-666 pubmed publisher
    ..007) and estimated D5D activity (p inter = 0.019). The IL6 gene SNP rs1800795 G allele is associated with increased odds for MetS...
  42. Kim H, Shin C, Lee H, Choi K, Nam D, Ohn T, et al. MicroRNA-1908-5p contributes to the oncogenic function of the splicing factor SRSF3. Oncotarget. 2017;8:8342-8355 pubmed publisher
    ..It also decreased the level of miR-1908 independent of its host gene FADS1. Although FADS1 was not associated with SRSF3-mediated malignant properties, overexpression of miR-1908-5p ..
  43. Janssen A, Betzel B, Stoopen G, Berends F, Janssen I, Peijnenburg A, et al. The impact of PPARα activation on whole genome gene expression in human precision cut liver slices. BMC Genomics. 2015;16:760 pubmed publisher
    ..05). Many genes induced by PPARα activation were involved in lipid metabolism (ACSL5, AGPAT9, FADS1, SLC27A4), xenobiotic metabolism (POR, ABCC2, CYP3A5) or the unfolded protein response, whereas most of the ..
  44. Mathias R, Sergeant S, Ruczinski I, Torgerson D, Hugenschmidt C, Kubala M, et al. The impact of FADS genetic variants on ?6 polyunsaturated fatty acid metabolism in African Americans. BMC Genet. 2011;12:50 pubmed publisher
    ..variants on PUFA metabolism, specifically AA levels, is likely more pronounced in African Americans due to the larger proportion of individuals carrying the genotype associated with increased FADS1 enzymatic conversion of DGLA to AA.
  45. Rondanelli M, Klersy C, Perna S, Faliva M, Montorfano G, Roderi P, et al. Effects of two-months balanced diet in metabolically healthy obesity: lipid correlations with gender and BMI-related differences. Lipids Health Dis. 2015;14:139 pubmed publisher
    ..001), delta-5 desaturase activity (D5D) (p = 0.002), glucagon like peptide-1 (p <0...
  46. Picklo M, Murphy E. A High-Fat, High-Oleic Diet, But Not a High-Fat, Saturated Diet, Reduces Hepatic α-Linolenic Acid and Eicosapentaenoic Acid Content in Mice. Lipids. 2016;51:537-47 pubmed publisher
    ..Docosahexaenoic acid (DHA; 22:6n-3) content was elevated by the high SFA diet. Expression of Fads1 (Δ5 desaturase) and Fads2 (Δ6 desaturase) was elevated by the high MUFA and reduced by the high SFA diet...
  47. Hu Y, Tanaka T, Zhu J, Guan W, Wu J, Psaty B, et al. Discovery and fine-mapping of loci associated with MUFAs through trans-ethnic meta-analysis in Chinese and European populations. J Lipid Res. 2017;58:974-981 pubmed publisher
    ..We identified novel genome-wide significant associations for vaccenic acid at FADS1/2 and PKD2L1 [log10(Bayes factor) ? 8...
  48. Wu M, Su H, Cui Y, Windust A, Chou H, Huang C. Fucoxanthin Enhances Chain Elongation and Desaturation of Alpha-Linolenic Acid in HepG2 Cells. Lipids. 2015;50:945-53 pubmed publisher
    ..Furthermore, estimated delta-5 desaturase (D5D) but not delta-6 desaturase (D6D) activity index was increased at 48 h...
  49. Shi H, Chen H, Gu Z, Song Y, Zhang H, Chen W, et al. Molecular mechanism of substrate specificity for delta 6 desaturase from Mortierella alpina and Micromonas pusilla. J Lipid Res. 2015;56:2309-21 pubmed publisher
    ..In both of these, delta 6 desaturase (FADS6) is a key bifunctional enzyme desaturating linoleic acid or α-linolenic acid...
  50. Kim S, Jeon S, Lee S. The association of cardiovascular risk factors with saturated fatty acids and fatty acid desaturase indices in erythrocyte in middle-aged Korean adults. Lipids Health Dis. 2015;14:133 pubmed publisher
    ..002 or p = 0.003). Conversely, TG and blood pressures showed inverse relationships with C20:4n6 or D5D (C20:4n6/C20:3n6)...
  51. Zhang J, Qin X, Park H, Kim E, Liu G, Kothapalli K, et al. Alternative splicing generates novel Fads3 transcript in mice. Mol Biol Rep. 2016;43:761-766 pubmed publisher
    ..conserved alternative transcripts (AT), having no clearly established function as are known for FADS2 and FADS1. Here we present identification of a novel Fads3 transcript in mice (Fads3AT9), characterize Fads3AT9 expression ..
  52. Li S, Wang J, Yang Y, Liu Z, Cheng L, Liu H, et al. Polymorphisms in FADS1 and FADS2 alter plasma fatty acids and desaturase levels in type 2 diabetic patients with coronary artery disease. J Transl Med. 2016;14:79 pubmed publisher
    ..Our results show that SNPs in FADS gene (particularly rs174537) associate with plasma fatty acids and desaturase levels in patients with both T2D and CAD, which maybe increases the risk of CAD in diabetic patients. ..
  53. Xu Y, Yang X, Zhao P, Yang Z, Yan C, Guo B, et al. Knockdown of delta-5-desaturase promotes the anti-cancer activity of dihomo-?-linolenic acid and enhances the efficacy of chemotherapy in colon cancer cells expressing COX-2. Free Radic Biol Med. 2016;96:67-77 pubmed publisher
    ..90% of colon cancer patients) can be taken advantage to suppress cell growth by knocking down delta-5-desaturase (D5D, a key enzyme that converts DGLA to arachidonic acid)...
  54. Horiguchi S, Nakayama K, Iwamoto S, Ishijima A, Minezaki T, Baba M, et al. Associations between a fatty acid desaturase gene polymorphism and blood arachidonic acid compositions in Japanese elderly. Prostaglandins Leukot Essent Fatty Acids. 2016;105:9-14 pubmed publisher
    We investigated whether the single nucleotide polymorphism rs174547 (T/C) of the fatty acid desaturase-1 gene, FADS1, is associated with changes in erythrocyte membrane and plasma phospholipid (PL) long-chain polyunsaturated fatty acid (..
  55. Reardon H, Zhang J, Kothapalli K, Kim A, Park W, Brenna J. Insertion-deletions in a FADS2 intron 1 conserved regulatory locus control expression of fatty acid desaturases 1 and 2 and modulate response to simvastatin. Prostaglandins Leukot Essent Fatty Acids. 2012;87:25-33 pubmed publisher
    The fatty acid desaturase genes (FADS1 and FADS2) code for enzymes required for synthesis of omega-3 and omega-6 long-chain polyunsaturated fatty acids (LCPUFA) important in the central nervous system, inflammatory response, and ..
  56. O Neill C, Minihane A. The impact of fatty acid desaturase genotype on fatty acid status and cardiovascular health in adults. Proc Nutr Soc. 2017;76:64-75 pubmed publisher
    ..5 and ?-6 desaturase enzymes, encoded for by FADS1 and FADS2 genes, are key desaturation enzymes involved in the bioconversion of essential fatty acids (?LNA and ..
  57. Zhu J, Sun Q, Zong G, Si Y, Liu C, Qi Q, et al. Interaction between a common variant in FADS1 and erythrocyte polyunsaturated fatty acids on lipid profile in Chinese Hans. J Lipid Res. 2013;54:1477-83 pubmed publisher
    Little is known about the associations of FADS1 genetic variants with circulating levels of PUFA and lipids in Asian populations who have a different dietary pattern and dyslipidemia prevalence compared with Western populations...
  58. Song Z, Cao H, Qin L, Jiang Y. A case-control study between gene polymorphisms of polyunsaturated fatty acid metabolic rate-limiting enzymes and acute coronary syndrome in Chinese Han population. Biomed Res Int. 2013;2013:928178 pubmed publisher
    The purpose of this study is to analyze the relationship between the polymorphisms of fatty acid desaturase 1 (FADS1), fatty acid desaturase 2 (FADS2), and elongation of very long-chain fatty acids-like 2 (ELOVL2) and acute coronary ..
  59. Solakivi T, Kunnas T, Jaakkola O, Renko J, Lehtimaki T, Nikkari S. Delta-6-desaturase gene polymorphism is associated with lipoprotein oxidation in vitro. Lipids Health Dis. 2013;12:80 pubmed publisher
    ..034). We conclude that FADS2 genotype may play a role in peroxidation susceptibility of lipoproteins. ..
  60. Fekete K, Györei E, Lohner S, Verduci E, Agostoni C, Decsi T. Long-chain polyunsaturated fatty acid status in obesity: a systematic review and meta-analysis. Obes Rev. 2015;16:488-97 pubmed publisher
    ..The results of the present meta-analysis confirm that LCPUFA profile is altered in obesity and suggest that the differences observed in desaturase activities may be responsible for the disturbed LCPUFA metabolism in obesity. ..
  61. Rahbar E, Ainsworth H, Howard T, Hawkins G, Ruczinski I, Mathias R, et al. Uncovering the DNA methylation landscape in key regulatory regions within the FADS cluster. PLoS ONE. 2017;12:e0180903 pubmed publisher
    ..polymorphism (SNP) rs174537 and DNA methylation of CpG sites located in the putative enhancer region between FADS1 and FADS2, in human liver tissue. However, this array only featured 20 CpG sites within this 12kb region...
  62. Hadj Ahmed S, Kaoubaa N, Kharroubi W, Zarrouk A, Najjar M, Batbout F, et al. Association of plasma fatty acid alteration with the severity of coronary artery disease lesions in Tunisian patients. Lipids Health Dis. 2017;16:154 pubmed publisher
    ..Higher elongation index and modifications of desaturation index (D5D, D6D and D9D) were observed in patients compared to controls, supporting FA metabolism modifications...
  63. Zietemann V, Kröger J, Enzenbach C, Jansen E, Fritsche A, Weikert C, et al. Genetic variation of the FADS1 FADS2 gene cluster and n-6 PUFA composition in erythrocyte membranes in the European Prospective Investigation into Cancer and Nutrition-Potsdam study. Br J Nutr. 2010;104:1748-59 pubmed publisher
    ..The goals were to evaluate the associations between variation in genes encoding these desaturases (FADS1 and FADS2) and blood concentrations of n-6 PUFA and estimated D5D and D6D activities (evaluated as product/..
  64. Dumont J, Goumidi L, Grenier Boley B, Cottel D, Marécaux N, Montaye M, et al. Dietary linoleic acid interacts with FADS1 genetic variability to modulate HDL-cholesterol and obesity-related traits. Clin Nutr. 2017;: pubmed publisher
    ..fatty acids (PUFAs) are under control of endogenous synthesis via ?5- and ?6-desaturases, encoded by the FADS1 and FADS2 genes, respectively and of diet...
  65. Standl M, Lattka E, Stach B, Koletzko S, Bauer C, von Berg A, et al. FADS1 FADS2 gene cluster, PUFA intake and blood lipids in children: results from the GINIplus and LISAplus studies. PLoS ONE. 2012;7:e37780 pubmed publisher
    ..of total cholesterol, LDL, HDL and lower triglyceride levels, but these associations did not interact with the FADS1 FADS2 genotype...
  66. Jack Roberts C, Joselit Y, Nanobashvili K, Bretter R, Malysheva O, Caudill M, et al. Choline Supplementation Normalizes Fetal Adiposity and Reduces Lipogenic Gene Expression in a Mouse Model of Maternal Obesity. Nutrients. 2017;9: pubmed publisher
    ..mRNA levels of lipogenic genes such as Acc1, Fads1, and Elovl5, as well as the transcription factor Srebp1c that favors lipogenesis were ..
  67. Roke K, Mutch D. The role of FADS1/2 polymorphisms on cardiometabolic markers and fatty acid profiles in young adults consuming fish oil supplements. Nutrients. 2014;6:2290-304 pubmed publisher
    ..Evidence suggests that single nucleotide polymorphisms (SNPs) in the fatty acid desaturase 1 and 2 (FADS1/2) gene cluster may influence an individual's response to n-3 FAs...
  68. Koletzko B, Demmelmair H, Schaeffer L, Illig T, Heinrich J. Genetically determined variation in polyunsaturated fatty acid metabolism may result in different dietary requirements. Nestle Nutr Workshop Ser Pediatr Program. 2008;62:35-44; discussion 44-9 pubmed publisher
    ..We found close associations between variants in the human genes of Delta5- and Delta6-desaturase, FADS1 and FADS2, and serum phospholipid contents of PUFAs and long-chain PUFAs (LCPUFAs)...
  69. Yang X, Xu Y, Wang T, Shu D, Guo P, Miskimins K, et al. Inhibition of cancer migration and invasion by knocking down delta-5-desaturase in COX-2 overexpressed cancer cells. Redox Biol. 2017;11:653-662 pubmed publisher
    ..With the shifting paradigm of COX-2 cancer biology, our research outcome may provide us a novel cancer treatment strategy. ..
  70. Chen F, He B, Yan L, Qiu Y, Lin L, Cai L. FADS1 rs174549 Polymorphism May Predict a Favorable Response to Chemoradiotherapy in Oral Cancer Patients. J Oral Maxillofac Surg. 2017;75:214-220 pubmed publisher
    The fatty acid desaturase 1 (FADS1) gene variant is a novel susceptibility marker for laryngeal squamous cell carcinoma identified by a recent genome-wide association study, but it is still unclear whether this genetic variant continues ..
  71. Yang X, Xu Y, Brooks A, Guo B, Miskimins K, Qian S. Knockdown delta-5-desaturase promotes the formation of a novel free radical byproduct from COX-catalyzed ω-6 peroxidation to induce apoptosis and sensitize pancreatic cancer cells to chemotherapy drugs. Free Radic Biol Med. 2016;97:342-350 pubmed publisher
    ..acid (DGLA, an ω-6 fatty acid) peroxidation from knocking down cellular delta-5-desaturase (D5D, the key enzyme for converting DGLA to the downstream ω-6, arachidonic acid)...
  72. Stohr H, Marquardt A, Rivera A, Cooper P, Nowak N, Shows T, et al. A gene map of the Best's vitelliform macular dystrophy region in chromosome 11q12-q13.1. Genome Res. 1998;8:48-56 pubmed
    ..The GenBank/EMBL accession numbers and details of the isolation, localization, and characterization of ESTs and selected cDNAs are available as online supplements in Online Tables 1-3 at http://www.genome.org.] ..
  73. Kothapalli K, Ye K, Gadgil M, Carlson S, O Brien K, Zhang J, et al. Positive Selection on a Regulatory Insertion-Deletion Polymorphism in FADS2 Influences Apparent Endogenous Synthesis of Arachidonic Acid. Mol Biol Evol. 2016;33:1726-39 pubmed publisher
    ..The rs66698963 polymorphism, a 22-bp insertion-deletion within FADS2, is associated with basal FADS1 expression, and coordinated induction of FADS1 and FADS2 in vitro...
  74. Sublette M, Vaquero C, Baca Garcia E, Pachano G, Huang Y, Oquendo M, et al. Lack of association of SNPs from the FADS1-FADS2 gene cluster with major depression or suicidal behavior. Psychiatr Genet. 2016;26:81-6 pubmed publisher
    Fatty acid desaturase genes (FADS1-FADS2) encode desaturases participating in the biosynthesis of long-chain polyunsaturated fatty acids...
  75. Takkunen M, de Mello V, Schwab U, Kuusisto J, Vaittinen M, Ã…gren J, et al. Gene-diet interaction of a common FADS1 variant with marine polyunsaturated fatty acids for fatty acid composition in plasma and erythrocytes among men. Mol Nutr Food Res. 2016;60:381-9 pubmed publisher
    ..examined gene-diet interaction of total marine PUFA intake with a known gene encoding Δ-5 desaturase enzyme (FADS1) variant (rs174550) for fatty acids in erythrocyte membranes and plasma phospholipids (PL), cholesteryl esters (CE)..
  76. Scholtz S, Kerling E, Shaddy D, Li S, Thodosoff J, Colombo J, et al. Docosahexaenoic acid (DHA) supplementation in pregnancy differentially modulates arachidonic acid and DHA status across FADS genotypes in pregnancy. Prostaglandins Leukot Essent Fatty Acids. 2015;94:29-33 pubmed publisher
    ..Any physiological effects of changing the DHA to ARA ratio by increasing DHA intake appears to be greater in minor allele homozygotes of some FADS SNPs. ..
  77. Hwang J, Sim X, Wu Y, Liang J, Tabara Y, Hu C, et al. Genome-wide association meta-analysis identifies novel variants associated with fasting plasma glucose in East Asians. Diabetes. 2015;64:291-8 pubmed publisher
    ..Our results could provide additional insight into the genetic variation implicated in fasting glucose regulation. ..
  78. Xia D, Sun L, Shi J, Yu Y, Xie L. [A case-control study between gene polymorphisms of polyunsaturated fatty acids metabolic rate-limiting enzymes and paranoid schizophrenia of Han ethnicity in Jilin Province]. Wei Sheng Yan Jiu. 2011;40:154-7 pubmed
    To investigate an association between gene polymorphisms of FADS 1 (fatty acid desaturase 1) , FADS2 (fatty acid desaturase 2) and ELOVL2 (elongation of very long chain fatty acids (FEN1/ Elo2, SUR4/Elo3, yeast) -like 2) and paranoid ..