factor H

Summary

Gene Symbol: factor H
Description: complement factor H
Alias: AHUS1, AMBP1, ARMD4, ARMS1, CFHL3, FHL1, HF1, HF2, HUS, complement factor H, H factor 1 (complement), H factor 2 (complement), adrenomedullin binding protein, age-related maculopathy susceptibility 1, beta-1-H-globulin, beta-1H, factor H, factor H-like 1
Species: human
Products:     factor H

Top Publications

  1. Seitsonen S, Jarvela I, Meri S, Tommila P, Ranta P, Immonen I. The effect of complement factor H Y402H polymorphism on the outcome of photodynamic therapy in age-related macular degeneration. Eur J Ophthalmol. 2007;17:943-9 pubmed
    ..The Y402H polymorphism of the complement factor H (CFH) gene has been identified as a risk factor for AMD...
  2. Smailhodzic D, Klaver C, Klevering B, Boon C, Groenewoud J, Kirchhof B, et al. Risk alleles in CFH and ARMS2 are independently associated with systemic complement activation in age-related macular degeneration. Ophthalmology. 2012;119:339-46 pubmed publisher
    ..with age-related macular degeneration (AMD) and has mainly been attributed to a risk allele in the complement factor H (CFH) gene. Whether other important AMD genes also influence complement activation is unclear...
  3. Haapasalo K, Jarva H, Siljander T, Tewodros W, Vuopio Varkila J, Jokiranta T. Complement factor H allotype 402H is associated with increased C3b opsonization and phagocytosis of Streptococcus pyogenes. Mol Microbiol. 2008;70:583-94 pubmed publisher
    The main virulence factor of group A streptococcus (GAS), M protein, binds plasma complement regulators factor H (FH) and FH-like protein 1 (FHL-1) leading to decreased opsonization...
  4. van de Ven J, Smailhodzic D, Boon C, Fauser S, Groenewoud J, Chong N, et al. Association analysis of genetic and environmental risk factors in the cuticular drusen subtype of age-related macular degeneration. Mol Vis. 2012;18:2271-8 pubmed
    ..The CD subtype of AMD was significantly associated with current smoking as well as variants in the complement factor H (CFH), age-related maculopathy susceptibility 2 (ARMS2), complement factor B/complement component 2 (CFB/C2)..
  5. Tortajada A, Montes T, Martinez Barricarte R, Morgan B, Harris C, de Cordoba S. The disease-protective complement factor H allotypic variant Ile62 shows increased binding affinity for C3b and enhanced cofactor activity. Hum Mol Genet. 2009;18:3452-61 pubmed publisher
    Mutations and polymorphisms in the gene encoding factor H (CFH) have been associated with atypical haemolytic uraemic syndrome, dense deposit disease and age-related macular degeneration...
  6. Hallström T, Zipfel P, Blom A, Lauer N, Forsgren A, Riesbeck K. Haemophilus influenzae interacts with the human complement inhibitor factor H. J Immunol. 2008;181:537-45 pubmed
    ..In this study, we identify two novel host-pathogen interactions, factor H (FH) and factor H-like protein 1 (FHL-1), the inhibitors of the alternative pathway that binds to Hib...
  7. van de Ven J, Boon C, Fauser S, Hoefsloot L, Smailhodzic D, Schoenmaker Koller F, et al. Clinical evaluation of 3 families with basal laminar drusen caused by novel mutations in the complement factor H gene. Arch Ophthalmol. 2012;130:1038-47 pubmed
    To identify novel complement factor H (CFH) gene mutations and to specify the clinical characteristics in patients with basal laminar drusen (BLD), a clinical subtype of age-related macular degeneration.
  8. Licht C, Pluthero F, Li L, Christensen H, Habbig S, Hoppe B, et al. Platelet-associated complement factor H in healthy persons and patients with atypical HUS. Blood. 2009;114:4538-45 pubmed publisher
    ..with complement system dysregulation, and more than 25% of pediatric aHUS cases are linked to mutations in complement factor H (CFH) or CFH autoantibodies...
  9. Yang X, Hu J, Zhang J, Guan H. Polymorphisms in CFH, HTRA1 and CX3CR1 confer risk to exudative age-related macular degeneration in Han Chinese. Br J Ophthalmol. 2010;94:1211-4 pubmed publisher
    Single nucleotide polymorphisms (SNPs) in Complement Factor H (CFH), HTRA1 and CX3CR1 are associated with age-related macular degeneration (AMD) in Caucasian population...

More Information

Publications132 found, 100 shown here

  1. Schneider M, Prosser B, Caesar J, Kugelberg E, Li S, Zhang Q, et al. Neisseria meningitidis recruits factor H using protein mimicry of host carbohydrates. Nature. 2009;458:890-3 pubmed publisher
    ..complement is precisely controlled through membrane-bound and soluble plasma-regulatory proteins including complement factor H (fH; ref. 2), a 155 kDa protein composed of 20 domains (termed complement control protein repeats)...
  2. Siegel C, Schreiber J, Haupt K, Skerka C, Brade V, Simon M, et al. Deciphering the ligand-binding sites in the Borrelia burgdorferi complement regulator-acquiring surface protein 2 required for interactions with the human immune regulators factor H and factor H-like protein 1. J Biol Chem. 2008;283:34855-63 pubmed publisher
    ..is the inhibition of complement activation mediated by interactions of the host-derived immune regulators factor H (CFH) and factor H-like protein 1 (CFHL1) with borrelial complement regulator-acquiring surface proteins (..
  3. Granoff D, Welsch J, Ram S. Binding of complement factor H (fH) to Neisseria meningitidis is specific for human fH and inhibits complement activation by rat and rabbit sera. Infect Immun. 2009;77:764-9 pubmed publisher
    b>Complement factor H (fH), a molecule that downregulates complement activation, binds to Neisseria meningitidis and increases resistance to serum bactericidal activity...
  4. Marioli D, Pharmakakis N, Deli A, Havvas I, Zarkadis I. Complement factor H and LOC387715 gene polymorphisms in a Greek population with age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol. 2009;247:1547-53 pubmed publisher
  5. Morgan H, Schmidt C, Guariento M, Blaum B, Gillespie D, Herbert A, et al. Structural basis for engagement by complement factor H of C3b on a self surface. Nat Struct Mol Biol. 2011;18:463-70 pubmed publisher
    b>Complement factor H (FH) attenuates C3b molecules tethered by their thioester domains to self surfaces and thereby protects host tissues...
  6. Canter J, Olson L, Spencer K, Schnetz Boutaud N, Anderson B, Hauser M, et al. Mitochondrial DNA polymorphism A4917G is independently associated with age-related macular degeneration. PLoS ONE. 2008;3:e2091 pubmed publisher
    ..20-3.91, p = 0.01). In conclusion, a specific mitochondrial polymorphism previously implicated in other neurodegenerative phenotypes (4917G) appears to convey risk for AMD independent of recently discovered nuclear DNA polymorphisms. ..
  7. Jakobsdottir J, Conley Y, Weeks D, Ferrell R, Gorin M. C2 and CFB genes in age-related maculopathy and joint action with CFH and LOC387715 genes. PLoS ONE. 2008;3:e2199 pubmed publisher
    ..Variants within two genes, the complement factor H (CFH) and the poorly characterized LOC387715 (ARMS2), are widely recognized as ARM risk factors...
  8. Klein R, Knudtson M, Klein B, Wong T, Cotch M, Liu K, et al. Inflammation, complement factor h, and age-related macular degeneration: the Multi-ethnic Study of Atherosclerosis. Ophthalmology. 2008;115:1742-9 pubmed publisher
    To describe the relationship of systemic inflammatory disease, complement factor H (CFH) Y402H (1277T-->C) genotype status and age-related macular degeneration (AMD) prevalence in a multiethnic population of whites, blacks, Hispanics, ..
  9. Bergeron Sawitzke J, Gold B, Olsh A, Schlotterbeck S, Lemon K, Visvanathan K, et al. Multilocus analysis of age-related macular degeneration. Eur J Hum Genet. 2009;17:1190-9 pubmed publisher
    ..Of the three identified complement loci, variants in complement factor H (CFH) have the highest impact as does an independent locus at 10q26...
  10. Sjöberg A, Trouw L, Blom A. Complement activation and inhibition: a delicate balance. Trends Immunol. 2009;30:83-90 pubmed publisher
    ..DNA, all bind the complement activator C1q, but also interact with complement inhibitors C4b-binding protein and factor H. This contrasts to the interaction between C1q and immune complexes, in which case no inhibitors bind, resulting ..
  11. Chaung W, Wu R, Ji Y, Wang Z, Dong W, Cheyuo C, et al. Peripheral administration of human adrenomedullin and its binding protein attenuates stroke-induced apoptosis and brain injury in rats. Mol Med. 2011;17:1075-83 pubmed publisher
    ..Thus, human AM/AMBP-1 has the ability to reduce stroke-induced brain injury in rats. AM/AMBP-1 can be developed as a novel therapeutic agent for patients with ischemic stroke. ..
  12. Wu J, Wu Y, Ricklin D, Janssen B, Lambris J, Gros P. Structure of complement fragment C3b-factor H and implications for host protection by complement regulators. Nat Immunol. 2009;10:728-33 pubmed publisher
    b>Factor H (FH) is an abundant regulator of complement activation and protects host cells from self-attack by complement...
  13. Clark S, Bishop P, Day A. Complement factor H and age-related macular degeneration: the role of glycosaminoglycan recognition in disease pathology. Biochem Soc Trans. 2010;38:1342-8 pubmed publisher
    ..cellular debris and proteins, including components of the complement system such as the regulator CFH (complement factor H); dysregulation of complement is thought to play a major role in the development of AMD...
  14. Scholl H, Charbel Issa P, Walier M, Janzer S, Pollok Kopp B, Börncke F, et al. Systemic complement activation in age-related macular degeneration. PLoS ONE. 2008;3:e2593 pubmed publisher
    ..of activation products C3d, Ba, C3a, C5a, SC5b-9, substrate proteins C3, C4, factor B and regulators factor H and factor D were quantified in patients (n = 112) and controls (n = 67)...
  15. Miki A, Honda S, Kondo N, Negi A. The association of age-related maculopathy susceptibility 2 (ARMS2) and complement factor H (CFH) variants with two angiographic subtypes of polypoidal choroidal vasculopathy. Ophthalmic Genet. 2013;34:146-50 pubmed publisher
    To compare the association of age-related maculopathy susceptibility 2 (ARMS2) and complement factor H (CFH) variants between two different angiographic phenotypes of polypoidal choroidal vasculopathy (PCV)...
  16. Lima L, Schubert C, Ferrara D, Merriam J, Imamura Y, Freund K, et al. Three major loci involved in age-related macular degeneration are also associated with polypoidal choroidal vasculopathy. Ophthalmology. 2010;117:1567-70 pubmed publisher
    ..To investigate the frequency of variants in 3 major age-related macular degeneration (AMD)-associated loci in patients of European-American descent with polypoidal choroidal vasculopathy (PCV)...
  17. Munch I, Ek J, Kessel L, Sander B, Almind G, Brøndum Nielsen K, et al. Small, hard macular drusen and peripheral drusen: associations with AMD genotypes in the Inter99 Eye Study. Invest Ophthalmol Vis Sci. 2010;51:2317-21 pubmed publisher
    ..Participants were genotyped for AMD-related polymorphisms in complement factor H (CFH), in LOC387715, and in complement factor B (CFB)...
  18. Bhattacharjee A, Lehtinen M, Kajander T, Goldman A, Jokiranta T. Both domain 19 and domain 20 of factor H are involved in binding to complement C3b and C3d. Mol Immunol. 2010;47:1686-91 pubmed publisher
    b>Factor H (FH) regulates the alternative pathway of complement in plasma and mediates discrimination of cellular surfaces to alternative pathway activators and non-activators...
  19. Weismann D, Hartvigsen K, Lauer N, Bennett K, Scholl H, Charbel Issa P, et al. Complement factor H binds malondialdehyde epitopes and protects from oxidative stress. Nature. 2011;478:76-81 pubmed publisher
    ..Here we identify complement factor H (CFH) as a major MDA-binding protein that can block both the uptake of MDA-modified proteins by macrophages ..
  20. Maciejewski M, Tjandra N, Barlow P. Estimation of interdomain flexibility of N-terminus of factor H using residual dipolar couplings. Biochemistry. 2011;50:8138-49 pubmed publisher
    ..We focused on the three N-terminal domains (called CCPs or SCRs) of the important complement regulator, human factor H (i.e., FH1-3)...
  21. Ferreira V, Herbert A, Cortes C, McKee K, Blaum B, Esswein S, et al. The binding of factor H to a complex of physiological polyanions and C3b on cells is impaired in atypical hemolytic uremic syndrome. J Immunol. 2009;182:7009-18 pubmed publisher
    b>Factor H (fH) is essential for complement homeostasis in fluid-phase and on surfaces. Its two C-terminal domains (CCP 19-20) anchor fH to self-surfaces where it prevents C3b amplification in a process requiring its N-terminal four domains...
  22. Khan S, Nan R, Gor J, Mulloy B, Perkins S. Bivalent and co-operative binding of complement factor H to heparan sulfate and heparin. Biochem J. 2012;444:417-28 pubmed publisher
    FH (Factor H) with 20 SCR (short complement regulator) domains is a major serum regulator of complement, and genetic defects in this are associated with inflammatory diseases...
  23. Leveziel N, Zerbib J, Richard F, Querques G, Morineau G, Fremeaux Bacchi V, et al. Genotype-phenotype correlations for exudative age-related macular degeneration associated with homozygous HTRA1 and CFH genotypes. Invest Ophthalmol Vis Sci. 2008;49:3090-4 pubmed publisher
    ..10.7%; P < 0.03). This attempt at a genotypic-angiographic correlation in an exudative AMD sample suggests an association between occult or MC CNV and the CFH polymorphism and between classic and PC CNV and the HTRA1 polymorphism. ..
  24. Lee A, Raya A, Kymes S, Shiels A, Brantley M. Pharmacogenetics of complement factor H (Y402H) and treatment of exudative age-related macular degeneration with ranibizumab. Br J Ophthalmol. 2009;93:610-3 pubmed publisher
    To determine whether complement factor H (CFH) genotypes have a pharmacogenetic effect on the treatment of exudative age-related macular degeneration (AMD) with ranibizumab...
  25. Seddon J, Gensler G, Rosner B. C-reactive protein and CFH, ARMS2/HTRA1 gene variants are independently associated with risk of macular degeneration. Ophthalmology. 2010;117:1560-6 pubmed publisher
    ..4, 95% CI 1.4-21.1). High-sensitivity CRP and polymorphisms in the CFH and ARMS2/HTRA1 genes are independently associated with risk of AMD. Higher CRP level tends to confer a higher risk of AMD within most genotype groups. ..
  26. Told R, Palkovits S, Haslacher H, Frantal S, Schmidl D, Boltz A, et al. Alterations of choroidal blood flow regulation in young healthy subjects with complement factor H polymorphism. PLoS ONE. 2013;8:e60424 pubmed publisher
    A common polymorphism in the complement factor H gene (rs1061170, Y402H) is associated with a high risk of age-related macular degeneration (AMD)...
  27. Brantley M, Osborn M, Sanders B, Rezaei K, Lu P, Li C, et al. Plasma biomarkers of oxidative stress and genetic variants in age-related macular degeneration. Am J Ophthalmol. 2012;153:460-467.e1 pubmed publisher
    ..isoprostane, and isofuran were measured, and participants were genotyped for polymorphisms in the complement factor H (CFH) and age-related maculopathy susceptibility 2 (ARMS2) genes...
  28. Sofat R, Casas J, Webster A, Bird A, Mann S, Yates J, et al. Complement factor H genetic variant and age-related macular degeneration: effect size, modifiers and relationship to disease subtype. Int J Epidemiol. 2012;41:250-62 pubmed publisher
    Variation in the complement factor H gene (CFH) is associated with risk of late age-related macular degeneration (AMD)...
  29. Gibson J, Cree A, Collins A, Lotery A, Ennis S. Determination of a gene and environment risk model for age-related macular degeneration. Br J Ophthalmol. 2010;94:1382-7 pubmed publisher
    ..We demonstrate a multifactorial model with significant differences in risk scores for cases versus controls (p=9.81×10(-71)) and across Age-Related Eye Disease Study (AREDS) score-stratified cases (p=1.88×10(-11)). ..
  30. Rayes J, Roumenina L, Dimitrov J, Repesse Y, Ing M, Christophe O, et al. The interaction between factor H and VWF increases factor H cofactor activity and regulates VWF prothrombotic status. Blood. 2014;123:121-5 pubmed publisher
    ..ECs synthesize both the clotting initiator von Willebrand factor (VWF) and the complement regulator factor H (FH). VWF is stored in EC Weibel-Palade bodies (WPBs), but the intracellular location of FH is not well defined...
  31. Yang M, Lai T, Tam P, Chiang S, Chan C, Luk F, et al. CFH 184G as a genetic risk marker for anterior uveitis in Chinese females. Mol Vis. 2011;17:2655-64 pubmed
    To investigate the association of three single nucleotide polymorphisms (SNPs) in the complement factor H (CFH), KIAA1109, and interleukin-27 (IL-27) genes in patients with anterior uveitis (AU)...
  32. Makou E, Mertens H, Maciejewski M, Soares D, Matis I, Schmidt C, et al. Solution structure of CCP modules 10-12 illuminates functional architecture of the complement regulator, factor H. J Mol Biol. 2012;424:295-312 pubmed publisher
    The 155-kDa plasma glycoprotein factor H (FH), which consists of 20 complement control protein (CCP) modules, protects self-tissue but not foreign organisms from damage by the complement cascade...
  33. Hagstrom S, Ying G, Pauer G, Sturgill Short G, Huang J, Callanan D, et al. Pharmacogenetics for genes associated with age-related macular degeneration in the Comparison of AMD Treatments Trials (CATT). Ophthalmology. 2013;120:593-599 pubmed publisher
    ..Although specific alleles for CFH, ARMS2, HTRA1, and C3 may predict the development of AMD, they did not predict response to anti-vascular endothelial growth factor therapy. ..
  34. Gotoh N, Yamada R, Nakanishi H, Saito M, Iida T, Matsuda F, et al. Correlation between CFH Y402H and HTRA1 rs11200638 genotype to typical exudative age-related macular degeneration and polypoidal choroidal vasculopathy phenotype in the Japanese population. Clin Exp Ophthalmol. 2008;36:437-42 pubmed
    ..3 x 10(-5). A common genetic background may exist between typical exudative AMD and PCV patients. Among the patients with these two clinical entities, those with a homozygous HTRA1 rs11200638 risk allele had larger CNV lesions. ..
  35. Lehtinen M, Rops A, Isenman D, van der Vlag J, Jokiranta T. Mutations of factor H impair regulation of surface-bound C3b by three mechanisms in atypical hemolytic uremic syndrome. J Biol Chem. 2009;284:15650-8 pubmed publisher
    ..with mutations in complement proteins, most frequently in the main plasma alternative pathway regulator factor H (FH)...
  36. Hecker L, Edwards A, Ryu E, Tosakulwong N, Baratz K, Brown W, et al. Genetic control of the alternative pathway of complement in humans and age-related macular degeneration. Hum Mol Genet. 2010;19:209-15 pubmed publisher
    ..Genetic variation across the genes encoding complement factor H (CFH), factor B (CFB) and component 3 (C3) was determined...
  37. Schmidt C, Herbert A, Mertens H, Guariento M, Soares D, Uhrin D, et al. The central portion of factor H (modules 10-15) is compact and contains a structurally deviant CCP module. J Mol Biol. 2010;395:105-22 pubmed publisher
    The first eight and the last two of 20 complement control protein (CCP) modules within complement factor H (fH) encompass binding sites for C3b and polyanionic carbohydrates...
  38. Donoso L, Vrabec T, Kuivaniemi H. The role of complement Factor H in age-related macular degeneration: a review. Surv Ophthalmol. 2010;55:227-46 pubmed publisher
    b>Factor H is a 155kDa sialic acid containing glycoprotein that plays an integral role in the regulation of the complement-mediated immune system that is involved in microbial defense, immune complex processing, and programmed cell death...
  39. Kopplin L, Igo R, Wang Y, Sivakumaran T, Hagstrom S, Peachey N, et al. Genome-wide association identifies SKIV2L and MYRIP as protective factors for age-related macular degeneration. Genes Immun. 2010;11:609-21 pubmed publisher
    ..In addition to the complement factor H (CFH) (P=2.3 × 10???) and age-related maculopathy susceptibility 2 (ARMS2) (P=1...
  40. Chowers I, Cohen Y, Goldenberg Cohen N, Vicuna Kojchen J, Lichtinger A, Weinstein O, et al. Association of complement factor H Y402H polymorphism with phenotype of neovascular age related macular degeneration in Israel. Mol Vis. 2008;14:1829-34 pubmed
    The Tyr402His variant of complement factor H (CFH) is associated with age-related macular degeneration (AMD) in several populations...
  41. Losonczy G, Fekete A, Vokó Z, Takacs L, Káldi I, Ajzner E, et al. Analysis of complement factor H Y402H, LOC387715, HTRA1 polymorphisms and ApoE alleles with susceptibility to age-related macular degeneration in Hungarian patients. Acta Ophthalmol. 2011;89:255-62 pubmed publisher
    ..We investigated the frequency of Tyr402His polymorphism of the complement factor H (CFH) gene, Ser69Ala polymorphism at LOC387715, rs11200638 polymorphism of the HTRA1 gene and different ..
  42. Wu R, Higuchi S, Dong W, Ji Y, Zhou M, Marini C, et al. Reversing established sepsis in rats with human vasoactive hormone adrenomedullin and its binding protein. Mol Med. 2009;15:28-33 pubmed publisher
    ..Thus, human AM/AMBP-1 can be further developed as a safe and effective therapy for patients with established sepsis. ..
  43. Haas P, Steindl K, Schmid Kubista K, Aggermann T, Krugluger W, Hageman G, et al. Complement factor H gene polymorphisms and Chlamydia pneumoniae infection in age-related macular degeneration. Eye (Lond). 2009;23:2228-32 pubmed publisher
    To investigate the association of the complement factor H gene (CFH)Y402H polymorphism and age-related macular degeneration (AMD) in the Austrian population (Caucasoid descent), and to determine whether there is an association between ..
  44. Okemefuna A, Nan R, Gor J, Perkins S. Electrostatic interactions contribute to the folded-back conformation of wild type human factor H. J Mol Biol. 2009;391:98-118 pubmed publisher
    b>Factor H (FH), a major serum regulator of C3b in the complement alternative pathway, is composed of 20 short complement regulator (SCR) domains...
  45. Scholl H, Fleckenstein M, Fritsche L, Schmitz Valckenberg S, Göbel A, Adrion C, et al. CFH, C3 and ARMS2 are significant risk loci for susceptibility but not for disease progression of geographic atrophy due to AMD. PLoS ONE. 2009;4:e7418 pubmed publisher
    ..Variants in the genes encoding complement factor H (CFH), complement component 3 (C3) and age-related maculopathy susceptibility 2 (ARMS2) have repeatedly ..
  46. Nan R, Gor J, Lengyel I, Perkins S. Uncontrolled zinc- and copper-induced oligomerisation of the human complement regulator factor H and its possible implications for function and disease. J Mol Biol. 2008;384:1341-52 pubmed publisher
    Polymorphisms in factor H (FH), a major regulator of complement activation, and the accumulation of high zinc concentrations in the outer retina are both associated with age-related macular degeneration...
  47. Despriet D, van Duijn C, Oostra B, Uitterlinden A, Hofman A, Wright A, et al. Complement component C3 and risk of age-related macular degeneration. Ophthalmology. 2009;116:474-480.e2 pubmed publisher
    ..3 (C3) gene and age-related macular degeneration (AMD), and to investigate the modifying effect of complement factor H (CFH) Y402H, LOC387715 A69S and smoking...
  48. McDowell J, Huang B, Fenno J, Marconi R. Analysis of a unique interaction between the complement regulatory protein factor H and the periodontal pathogen Treponema denticola. Infect Immun. 2009;77:1417-25 pubmed publisher
    ..Earlier analyses suggested that FhbB specifically bound to factor H (FH)-like protein 1 (FHL-1). However, by using dentilisin-deficient mutants of T. denticola, we found that T...
  49. Buelli S, Abbate M, Morigi M, Moioli D, Zanchi C, Noris M, et al. Protein load impairs factor H binding promoting complement-dependent dysfunction of proximal tubular cells. Kidney Int. 2009;75:1050-9 pubmed publisher
    ..This paralleled active C3 and C5b-9 generations, effects not shared by transferrin. Factor H, one of the main natural inhibitors of the alternative pathway, binds to heparan sulfate proteoglycans...
  50. Dieguez Gonzalez R, Akar S, Calaza M, Gonzalez Alvaro I, Fernandez Gutierrez B, Lamas J, et al. Lack of association with rheumatoid arthritis of selected polymorphisms in 4 candidate genes: CFH, CD209, eotaxin-3, and MHC2TA. J Rheumatol. 2009;36:1590-5 pubmed publisher
    ..associations with rheumatoid arthritis (RA) of single-nucleotide polymorphisms (SNP) in 4 candidate genes, complement factor H (CFH), CD209 or DC-SIGN, eotaxin-3, and the MHC class II Transactivator (MHC2TA) genes...
  51. Chen W, Stambolian D, Edwards A, Branham K, Othman M, Jakobsdottir J, et al. Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration. Proc Natl Acad Sci U S A. 2010;107:7401-6 pubmed publisher
    ..Our studies extend the catalog of AMD associated loci, help identify individuals at high risk of disease, and provide clues about underlying cellular pathways that should eventually lead to new therapies. ..
  52. Kloeckener Gruissem B, Barthelmes D, Labs S, Schindler C, Kurz Levin M, Michels S, et al. Genetic association with response to intravitreal ranibizumab in patients with neovascular AMD. Invest Ophthalmol Vis Sci. 2011;52:4694-702 pubmed publisher
    ..Genetic predisposition may account for the variability in response to anti-VEGF treatment. ..
  53. Holliday E, Smith A, Cornes B, Buitendijk G, Jensen R, Sim X, et al. Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis. PLoS ONE. 2013;8:e53830 pubmed publisher
    ..GWAS meta-analysis confirmed previously reported association of variants at the complement factor H (CFH) (peak P = 1...
  54. Francis P, Hamon S, Ott J, Weleber R, Klein M. Polymorphisms in C2, CFB and C3 are associated with progression to advanced age related macular degeneration associated with visual loss. J Med Genet. 2009;46:300-7 pubmed publisher
    ..Five genes have now been shown to be independently involved in progression from intermediate disease (before vision loss has occurred) to advanced disease in which blindness is frequent. ..
  55. Mori K, Horie Inoue K, Gehlbach P, Takita H, Kabasawa S, Kawasaki I, et al. Phenotype and genotype characteristics of age-related macular degeneration in a Japanese population. Ophthalmology. 2010;117:928-38 pubmed publisher
    ..Four single nucleotide polymorphisms (SNPs; rs800292, rs1061170, rs1410996, rs2274700) in the complement factor H (CFH) gene, 1 SNP (rs11200638) in the high-temperature requirement factor A1 (HTRA1) gene, 3 SNPs (rs699947,..
  56. Raychaudhuri S, Ripke S, Li M, Neale B, Fagerness J, Reynolds R, et al. Associations of CFHR1-CFHR3 deletion and a CFH SNP to age-related macular degeneration are not independent. Nat Genet. 2010;42:553-5; author reply 555-6 pubmed publisher
  57. Noris M, Caprioli J, Bresin E, Mossali C, Pianetti G, Gamba S, et al. Relative role of genetic complement abnormalities in sporadic and familial aHUS and their impact on clinical phenotype. Clin J Am Soc Nephrol. 2010;5:1844-59 pubmed publisher
    ..In >70% of sporadic and familial cases, gene mutations, disease-associated factor H (CFH) polymorphisms, or anti-CFH autoantibodies were found...
  58. Pechtl I, Kavanagh D, McIntosh N, Harris C, Barlow P. Disease-associated N-terminal complement factor H mutations perturb cofactor and decay-accelerating activities. J Biol Chem. 2011;286:11082-90 pubmed publisher
    ..syndrome (aHUS) lie within complement control protein modules 19-20 at the C terminus of the complement regulator factor H (FH). This region mediates preferential action of FH on self, as opposed to foreign, membranes and surfaces...
  59. Shen D, Tuo J, Patel M, Herzlich A, Ding X, Chew E, et al. Chlamydia pneumoniae infection, complement factor H variants and age-related macular degeneration. Br J Ophthalmol. 2009;93:405-8 pubmed publisher
    Impaired inhibition of the alternative complement pathway by complement factor H (CFH) is linked to age-related macular degeneration (AMD) based on the strong association between CFH variant and AMD...
  60. Robman L, Baird P, Dimitrov P, Richardson A, Guymer R. C-reactive protein levels and complement factor H polymorphism interaction in age-related macular degeneration and its progression. Ophthalmology. 2010;117:1982-8 pubmed publisher
    To determine the effect of elevated level of C-reactive protein (CRP) and its joint effect with the complement factor H (CFH) polymorphism on prevalent age-related macular degeneration (AMD) and its progression...
  61. Davila S, Wright V, Khor C, Sim K, Binder A, Breunis W, et al. Genome-wide association study identifies variants in the CFH region associated with host susceptibility to meningococcal disease. Nat Genet. 2010;42:772-6 pubmed publisher
    ..A cluster of complement factor SNPs replicated independently in both cohorts, including SNPs within complement factor H (CFH) (rs1065489 (p.936D<E), P = 2.2 x 10(-11)) and in CFH-related protein 3 (CFHR3)(rs426736, P = 4...
  62. McKibbin M, Ali M, Bansal S, Baxter P, West K, Williams G, et al. CFH, VEGF and HTRA1 promoter genotype may influence the response to intravitreal ranibizumab therapy for neovascular age-related macular degeneration. Br J Ophthalmol. 2012;96:208-12 pubmed publisher
    ..This study reports preliminary evidence suggesting that the higher AMD risk genotypes in CFH, VEGF and HTRA1 may influence the short-term response to treatment with ranibizumab for neovascular AMD. ..
  63. Ambati J, Atkinson J, Gelfand B. Immunology of age-related macular degeneration. Nat Rev Immunol. 2013;13:438-51 pubmed publisher
    ..We outline the diverse immune cell types, inflammatory activators and pathways that are involved. Finally, we discuss the future of inflammation-directed therapeutics to treat AMD in the growing aged population. ..
  64. Lee K, Vithana E, Mathur R, Yong V, Yeo I, Thalamuthu A, et al. Association analysis of CFH, C2, BF, and HTRA1 gene polymorphisms in Chinese patients with polypoidal choroidal vasculopathy. Invest Ophthalmol Vis Sci. 2008;49:2613-9 pubmed publisher
    ..Variants in the C2 and BF genes have been found to confer a significantly reduced risk of AMD. This study was undertaken to determine whether these associations occur in Chinese patients with PCV...
  65. Ziskind A, Bardien S, van der Merwe L, Webster A. The frequency of the H402 allele of CFH and its involvement with age-related maculopathy in an aged Black African Xhosa population. Ophthalmic Genet. 2008;29:117-9 pubmed publisher
    ..The aim of the present study was to estimate the frequency of the C allele of the CFH Y402H variant in an aged South African Black Xhosa population and to describe the evidence of ARMD found. ..
  66. Moore I, Strain L, Pappworth I, Kavanagh D, Barlow P, Herbert A, et al. Association of factor H autoantibodies with deletions of CFHR1, CFHR3, CFHR4, and with mutations in CFH, CFI, CD46, and C3 in patients with atypical hemolytic uremic syndrome. Blood. 2010;115:379-87 pubmed publisher
    ..By using multiplex ligation-dependent probe amplification we measured complement factor H-related (CFHR)1 and CFHR3 copy number...
  67. Xu Y, Guan N, Xu J, Yang X, Ma K, Zhou H, et al. Association of CFH, LOC387715, and HTRA1 polymorphisms with exudative age-related macular degeneration in a northern Chinese population. Mol Vis. 2008;14:1373-81 pubmed
    Variants in complement factor H (CFH), the hypothetical LOC387715, and the high-temperature requirement A-1 (HTRA1) genes have been reported to be associated with age-related macular degeneration (AMD)...
  68. Griffiths M, Neal J, Fontaine M, Das T, Gasque P. Complement factor H, a marker of self protects against experimental autoimmune encephalomyelitis. J Immunol. 2009;182:4368-77 pubmed publisher
    ..signals (CD200, CD47, CD22, fractalkine, semaphorins), we herein identify the key role of complement regulator factor H (fH) in controlling neuroinflammation initiated in an acute mouse model of Ab-dependent experimental autoimmune ..
  69. Agarwal V, Asmat T, Luo S, Jensch I, Zipfel P, Hammerschmidt S. Complement regulator Factor H mediates a two-step uptake of Streptococcus pneumoniae by human cells. J Biol Chem. 2010;285:23486-95 pubmed publisher
    Streptococcus pneumoniae, a human pathogen, recruits complement regulator factor H to its bacterial cell surface. The bacterial PspC protein binds Factor H via short consensus repeats (SCR) 8-11 and SCR19-20...
  70. Perkins S, Okemefuna A, Nan R. Unravelling protein-protein interactions between complement factor H and C-reactive protein using a multidisciplinary strategy. Biochem Soc Trans. 2010;38:894-900 pubmed publisher
    ..in analysing complement interactions is augmented by the multivalency of its main regulator, CFH (complement factor H), for its physiological or pathophysiological ligands...
  71. Silva A, Teixeira A, Bavia L, Lin F, Velletri R, Belfort R, et al. Plasma levels of complement proteins from the alternative pathway in patients with age-related macular degeneration are independent of Complement Factor H Tyr??²His polymorphism. Mol Vis. 2012;18:2288-99 pubmed
    To investigate the influence of the Factor H (CFH) Tyr??²His polymorphism on the plasma levels of the alternative pathway proteins CFH, C3, Factor B (FB), Factor D (FD), and Factor I (FI) and the inflammatory marker C-reactive protein (..
  72. Neale B, Fagerness J, Reynolds R, Sobrin L, Parker M, Raychaudhuri S, et al. Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC). Proc Natl Acad Sci U S A. 2010;107:7395-400 pubmed publisher
    ..Results implicate different biologic pathways than previously reported and provide new avenues for prevention and treatment of AMD. ..
  73. Clark S, Perveen R, Hakobyan S, Morgan B, Sim R, Bishop P, et al. Impaired binding of the age-related macular degeneration-associated complement factor H 402H allotype to Bruch's membrane in human retina. J Biol Chem. 2010;285:30192-202 pubmed publisher
    ..Recent genetic association studies have demonstrated that a common allele (402H) of the complement factor H (CFH) gene is a major risk factor for the development of AMD; CFH suppresses complement activation on host ..
  74. Tanaka K, Nakayama T, Mori R, Sato N, Kawamura A, Mizutani Y, et al. Associations of complement factor H (CFH) and age-related maculopathy susceptibility 2 (ARMS2) genotypes with subtypes of polypoidal choroidal vasculopathy. Invest Ophthalmol Vis Sci. 2011;52:7441-4 pubmed publisher
    To clarify whether complement factor H (CFH) and age-related maculopathy susceptibility 2 (ARMS2) genotypes are associated with subtypes of polypoidal choroidal vasculopathy (PCV), such as polypoidal choroidal neovascularization (CNV) ..
  75. Zhang H, Morrison M, Dewan A, Adams S, Andreoli M, Huynh N, et al. The NEI/NCBI dbGAP database: genotypes and haplotypes that may specifically predispose to risk of neovascular age-related macular degeneration. BMC Med Genet. 2008;9:51 pubmed publisher
    ..This is the first replication study on the NEI dbGAP SNPs, demonstrating that alleles on 1q, 2q and 10q may predispose an individual to AMD. ..
  76. Skerka C, Zipfel P. Complement factor H related proteins in immune diseases. Vaccine. 2008;26 Suppl 8:I9-14 pubmed
    ..This group includes the major alternative pathway regulator, complement factor H (CFH) and five complement factor H related proteins (CFHR)...
  77. Liu X, Zhao P, Tang S, Lu F, Hu J, Lei C, et al. Association study of complement factor H, C2, CFB, and C3 and age-related macular degeneration in a Han Chinese population. Retina. 2010;30:1177-84 pubmed publisher
    Genes in the complement pathway, including complement factor H (CFH), C2/BF, and C3, have been reported to be associated with age-related macular degeneration (AMD)...
  78. Tsuchihashi T, Mori K, Horie Inoue K, Gehlbach P, Kabasawa S, Takita H, et al. Complement factor H and high-temperature requirement A-1 genotypes and treatment response of age-related macular degeneration. Ophthalmology. 2011;118:93-100 pubmed publisher
    To determine whether there is an association between complement factor H (CFH), high-temperature requirement A-1 (HTRA1), vascular endothelial growth factor (VEGF), and pigment epithelium-derived factor (PEDF) genotypes and response to ..
  79. Sofat R, Casas J, Kumari M, Talmud P, Ireland H, Kivimaki M, et al. Genetic variation in complement factor H and risk of coronary heart disease: eight new studies and a meta-analysis of around 48,000 individuals. Atherosclerosis. 2010;213:184-90 pubmed publisher
    To investigate the association of polymorphisms in complement factor H (CFH) and coronary heart disease (CHD) using meta-analysis. Age-related macular degeneration (AMD) and CHD may share partially overlapping pathogenesis...
  80. Pechtl I, Neely R, Dryden D, Jones A, Barlow P. Use of time-resolved FRET to validate crystal structure of complement regulatory complex between C3b and factor H (N terminus). Protein Sci. 2011;20:2102-12 pubmed publisher
    ..to investigate the 10 ?M K(D) (210 kD) complex between the N-terminal region of the soluble complement regulator, factor H (FH1-4), and the key activation-specific complement fragment, C3b...
  81. Shaw P, Zhang L, Zhang M, Du H, Zhao L, Lee C, et al. Complement factor H genotypes impact risk of age-related macular degeneration by interaction with oxidized phospholipids. Proc Natl Acad Sci U S A. 2012;109:13757-62 pubmed publisher
    The rs1061170T/C variant encoding the Y402H change in complement factor H (CFH) has been identified by genome-wide association studies as being significantly associated with age-related macular degeneration (AMD)...
  82. Cao S, Ko A, Partanen M, Pakzad Vaezi K, Merkur A, Albiani D, et al. Relationship between systemic cytokines and complement factor H Y402H polymorphism in patients with dry age-related macular degeneration. Am J Ophthalmol. 2013;156:1176-83 pubmed publisher
    To investigate the relationship between systemic cytokines, the complement factor H (CFH) Y402H polymorphism, drusen load, and subfoveal choroidal thickness in patients with dry age-related macular degeneration (AMD)...
  83. Kaur I, Katta S, Hussain A, Hussain N, Mathai A, Narayanan R, et al. Variants in the 10q26 gene cluster (LOC387715 and HTRA1) exhibit enhanced risk of age-related macular degeneration along with CFH in Indian patients. Invest Ophthalmol Vis Sci. 2008;49:1771-6 pubmed publisher
    ..These associations underscore their significant involvement in AMD susceptibility, which may be useful for predictive testing. ..
  84. Feng X, Xiao J, Longville B, Tan A, Wu X, Cooper M, et al. Complement factor H Y402H and C-reactive protein polymorphism and photodynamic therapy response in age-related macular degeneration. Ophthalmology. 2009;116:1908-12.e1 pubmed publisher
    To investigate the association between complement factor H (CFH) and C-reactive protein (CRP) genotypes and response to photodynamic therapy (PDT) treatment for neovascular age-related macular degeneration (AMD)...
  85. Gao Y, Li Y, Xu L, Li Y, Zhang H, Jonas J, et al. Complement factor H polymorphism in age-related maculopathy in the Chinese population: the Beijing Eye Study. Retina. 2010;30:443-6 pubmed publisher
    The purpose of this study was to analyze the association between the Y402H polymorphism in the complement factor H and soft drusen of the macula as part of age-related maculopathy in the Chinese population...
  86. Nonyane B, Nitsch D, Whittaker J, Sofat R, Smeeth L, Chakravarthy U, et al. An ecological correlation study of late age-related macular degeneration and the complement factor H Y402H polymorphism. Invest Ophthalmol Vis Sci. 2010;51:2393-402 pubmed publisher
    ..Data in African, Middle Eastern, and South American populations are needed to provide a better understanding of the association of late AMD genetic risk across ethnicities. ..
  87. Seitsonen S, Onkamo P, Peng G, Xiong M, Tommila P, Ranta P, et al. Multifactor effects and evidence of potential interaction between complement factor H Y402H and LOC387715 A69S in age-related macular degeneration. PLoS ONE. 2008;3:e3833 pubmed publisher
    ..39, p = 0.039; blood donor controls), respectively. Previously, we have shown a strong association between complement factor H (CFH) Y402H and AMD in the Finnish population...
  88. Lundh von Leithner P, Kam J, Bainbridge J, Catchpole I, Gough G, Coffey P, et al. Complement factor h is critical in the maintenance of retinal perfusion. Am J Pathol. 2009;175:412-21 pubmed publisher
    ..Recently, age-related macular degeneration was associated with a single-nucleotide substitution of the complement factor H (CFH) gene, part of the alternative pathway of the complement system, a critical element in the innate ..
  89. Fritsche L, Lauer N, Hartmann A, Stippa S, Keilhauer C, Oppermann M, et al. An imbalance of human complement regulatory proteins CFHR1, CFHR3 and factor H influences risk for age-related macular degeneration (AMD). Hum Mol Genet. 2010;19:4694-704 pubmed publisher
    A frequent deletion of complement factor H (CFH)-related genes CFHR3 and CFHR1 (?CFHR3/CFHR1) is considered to have a protective effect against age-related macular degeneration (AMD), although the underlying mechanism remains elusive...
  90. Nan R, Farabella I, Schumacher F, Miller A, Gor J, Martin A, et al. Zinc binding to the Tyr402 and His402 allotypes of complement factor H: possible implications for age-related macular degeneration. J Mol Biol. 2011;408:714-35 pubmed publisher
    The Tyr402His polymorphism of complement factor H (FH) with 20 short complement regulator (SCR) domains is associated with age-related macular degeneration (AMD). How FH contributes to disease pathology is not clear...
  91. Sakurada Y, Kubota T, Imasawa M, Mabuchi F, Tateno Y, Tanabe N, et al. Role of complement factor H I62V and age-related maculopathy susceptibility 2 A69S variants in the clinical expression of polypoidal choroidal vasculopathy. Ophthalmology. 2011;118:1402-7 pubmed publisher
    To investigate the role of complement factor H (CFH) I62V (rs800292) and age-related maculopathy susceptibility 2 (ARMS2) A69S (rs10490924) variants in the clinical characteristics of polypoidal choroidal vasculopathy (PCV)...
  92. Blanc C, Roumenina L, Ashraf Y, Hyvärinen S, Sethi S, Ranchin B, et al. Overall neutralization of complement factor H by autoantibodies in the acute phase of the autoimmune form of atypical hemolytic uremic syndrome. J Immunol. 2012;189:3528-37 pubmed
    ..Complement is a major innate immune surveillance system. One of its most important regulators is the plasma protein factor H (FH)...