Gene Symbol: FABP7
Description: fatty acid binding protein 7
Alias: B-FABP, BLBP, FABPB, MRG, fatty acid-binding protein, brain, brain lipid-binding protein, brain-type fatty acid-binding protein, mammary-derived growth inhibitor-related
Species: human
Products:     FABP7

Top Publications

  1. Mita R, Beaulieu M, Field C, Godbout R. Brain fatty acid-binding protein and omega-3/omega-6 fatty acids: mechanistic insight into malignant glioma cell migration. J Biol Chem. 2010;285:37005-15 pubmed publisher
    ..Brain fatty acid-binding protein (FABP7), which binds docosahexaenoic acid (DHA) and arachidonic acid (AA), localizes to sites of tumor infiltration and ..
  2. Brun M, Coles J, Monckton E, Glubrecht D, Bisgrove D, Godbout R. Nuclear factor I regulates brain fatty acid-binding protein and glial fibrillary acidic protein gene expression in malignant glioma cell lines. J Mol Biol. 2009;391:282-300 pubmed publisher
    ..normally found in astrocytes, and the radial glial marker brain fatty acid-binding protein (B-FABP; also known as FABP7) are co-expressed in malignant glioma cell lines and tumors...
  3. Tang X, Umemura S, Tsukamoto H, Kumaki N, Tokuda Y, Osamura R. Overexpression of fatty acid binding protein-7 correlates with basal-like subtype of breast cancer. Pathol Res Pract. 2010;206:98-101 pubmed publisher
  4. Mita R, Coles J, Glubrecht D, Sung R, Sun X, Godbout R. B-FABP-expressing radial glial cells: the malignant glioma cell of origin?. Neoplasia. 2007;9:734-44 pubmed
    ..Thus, targeting B-FABP-expressing cells may make a significant impact on the treatment of these tumors. ..
  5. Kaloshi G, Mokhtari K, Carpentier C, Taillibert S, Lejeune J, Marie Y, et al. FABP7 expression in glioblastomas: relation to prognosis, invasion and EGFR status. J Neurooncol. 2007;84:245-8 pubmed
    b>FABP7 expression has been analysed in a series of 123 glioblastomas (68 pure GBM, 55 GBMO, i.e. with oligodendroglial component)...
  6. de Wit N, Rijntjes J, Diepstra J, van Kuppevelt T, Weidle U, Ruiter D, et al. Analysis of differential gene expression in human melanocytic tumour lesions by custom made oligonucleotide arrays. Br J Cancer. 2005;92:2249-61 pubmed
    ..For at least nine of these genes, namely THBD, FABP7, H2AFJ, RRAGD, MYADM, HR, CKS2, NCK2 and GDF15, the differential expression found by array analyses could be ..
  7. Anthony T, Mason H, Gridley T, Fishell G, Heintz N. Brain lipid-binding protein is a direct target of Notch signaling in radial glial cells. Genes Dev. 2005;19:1028-33 pubmed
    ..To elucidate pathways involved in these functions, we mapped in vivo the promoter for Blbp, a radial glial gene...
  8. Liang Y, Diehn M, Watson N, Bollen A, Aldape K, Nicholas M, et al. Gene expression profiling reveals molecularly and clinically distinct subtypes of glioblastoma multiforme. Proc Natl Acad Sci U S A. 2005;102:5814-9 pubmed
    ..We further investigated one gene from the group, FABP7, and confirmed its association with survival in two unrelated cohorts totaling 105 patients...
  9. Sánchez Font M, Bosch Comas A, Gonzalez Duarte R, Marfany G. Overexpression of FABP7 in Down syndrome fetal brains is associated with PKNOX1 gene-dosage imbalance. Nucleic Acids Res. 2003;31:2769-77 pubmed
    ..subtractive hybridization performed on Down syndrome (DS) fetal brains revealed a differentially expressed gene, FABP7, mapped to 6q22-23. FABP7 overexpression in DS brains was verified by real-time PCR (1.63-fold)...

More Information


  1. Miller S, Li H, Rizvi T, Huang Y, Johansson G, Bowersock J, et al. Brain lipid binding protein in axon-Schwann cell interactions and peripheral nerve tumorigenesis. Mol Cell Biol. 2003;23:2213-24 pubmed
    ..Using cDNA microarrays, we found that brain lipid binding protein (BLBP) is elevated in an EGFR-positive subpopulation of Nf1 mutant mouse Schwann cells (Nf1(-/-) TXF) ..
  2. Tölle A, Krause H, Miller K, Jung K, Stephan C. Importance of brain?type fatty acid binding protein for cell-biological processes in human renal carcinoma cells. Oncol Rep. 2011;25:1307-12 pubmed publisher
    ..An effect on the process of invasion was not observed. Our data suggest that B?FABP is involved in cell proliferation and migration of human renal carcinoma cells. The detailed molecular mechanisms remain to be elucidated. ..
  3. Takaoka N, Takayama T, Teratani T, Sugiyama T, Mugiya S, Ozono S. Analysis of the regulation of fatty acid binding protein 7 expression in human renal carcinoma cell lines. BMC Mol Biol. 2011;12:31 pubmed publisher
    ..One such marker may be fatty acid binding protein 7 (FABP7), also known as B-FABP and BLBP, which is expressed normally in radial glial cells of the developing central ..
  4. Alshareeda A, Rakha E, Nolan C, Ellis I, Green A. Fatty acid binding protein 7 expression and its sub-cellular localization in breast cancer. Breast Cancer Res Treat. 2012;134:519-29 pubmed publisher
    b>FABP7 is a member of the multi-gene fatty acid binding protein family...
  5. Godbout R, Bisgrove D, Shkolny D, Day R. Correlation of B-FABP and GFAP expression in malignant glioma. Oncogene. 1998;16:1955-62 pubmed
    ..We suggest that some malignant gliomas may be derived from astrocytic precursor cells which can express proteins that are normally produced at different developmental stages in the astrocytic differentiation pathway. ..
  6. Shimizu F, Watanabe T, Shinomiya H, Nakamura Y, Fujiwara T. Isolation and expression of a cDNA for human brain fatty acid-binding protein (B-FABP). Biochim Biophys Acta. 1997;1354:24-8 pubmed
    ..The elevated level of transcript at immature stages and its subsequent decline In adult brain indicate that the encoded protein may be essential for development of the human brain. ..
  7. Yun S, Leong C, Zhai D, Tan Y, Lim L, Bi X, et al. Neural stem cell specific fluorescent chemical probe binding to FABP7. Proc Natl Acad Sci U S A. 2012;109:10214-7 pubmed publisher
    ..its binding target by proteomic analysis as fatty acid binding protein 7 (FABP7), also known as brain lipid binding protein) which is highly expressed in neural stem cells and localized in the cytoplasm...
  8. Shi Y, Ni J, Xiao G, Liu Y, Fuchs A, Yu G, et al. Antitumor activity of the novel human breast cancer growth inhibitor, mammary-derived growth inhibitor-related gene, MRG. Cancer Res. 1997;57:3084-91 pubmed
    ..to mouse mammary-derived growth inhibitor and thus was named mammary-derived growth inhibitor-related gene (MRG). MRG was found to be expressed in normal and benign human breast tissues but not in breast carcinomas...
  9. De Rosa A, Pellegatta S, Rossi M, Tunici P, Magnoni L, Speranza M, et al. A radial glia gene marker, fatty acid binding protein 7 (FABP7), is involved in proliferation and invasion of glioblastoma cells. PLoS ONE. 2012;7:e52113 pubmed publisher
    ..Fatty acid-binding protein 7 (FABP7) was identified as one of the most highly expressed genes in NS compared to their adherent counterpart...
  10. Xu L, Sanchez R, Sali A, Heintz N. Ligand specificity of brain lipid-binding protein. J Biol Chem. 1996;271:24711-9 pubmed
    Brain lipid-binding protein (BLBP) is a member of the fatty acid-binding protein (FABP) family...
  11. Liu R, Graham K, Glubrecht D, Lai R, Mackey J, Godbout R. A fatty acid-binding protein 7/RXR? pathway enhances survival and proliferation in triple-negative breast cancer. J Pathol. 2012;228:310-21 pubmed publisher
    b>FABP7 has been implicated in tumour cell proliferation, cell migration, and poor prognosis in patients with high-grade astrocytoma and melanoma...
  12. Liu R, Mita R, Beaulieu M, Gao Z, Godbout R. Fatty acid binding proteins in brain development and disease. Int J Dev Biol. 2010;54:1229-39 pubmed publisher
    ..Three of the ten mammalian FABPs identified to date (FABP3, FABP5, FABP7) are expressed in the brain...
  13. Maekawa M, Iwayama Y, Arai R, Nakamura K, Ohnishi T, Toyota T, et al. Polymorphism screening of brain-expressed FABP7, 5 and 3 genes and association studies in autism and schizophrenia in Japanese subjects. J Hum Genet. 2010;55:127-30 pubmed publisher
    ..protein (FABP) gene family encode fatty acid-binding proteins and consist of at least 12 members, of which FABP7, 5 and 3 are expressed in the brain...
  14. Tölle A, Jung M, Lein M, Johannsen M, Miller K, Moch H, et al. Brain-type and liver-type fatty acid-binding proteins: new tumor markers for renal cancer?. BMC Cancer. 2009;9:248 pubmed publisher
    ..Further studies should identify the role of both FABPs in carcinogenesis, progression and with regard to a potential target in RCC. ..
  15. Zhang H, Rakha E, Ball G, Spiteri I, Aleskandarany M, Paish E, et al. The proteins FABP7 and OATP2 are associated with the basal phenotype and patient outcome in human breast cancer. Breast Cancer Res Treat. 2010;121:41-51 pubmed publisher
    ..We analysed 48,000 gene transcripts in 132 invasive breast carcinomas to identify two novel genes (OATP2 and FABP7) significantly associated with BP [defined by cytokeratin (CK)5/6 and/or CK14 positivity]...
  16. Goto Y, Koyanagi K, Narita N, Kawakami Y, Takata M, Uchiyama A, et al. Aberrant fatty acid-binding protein-7 gene expression in cutaneous malignant melanoma. J Invest Dermatol. 2010;130:221-9 pubmed publisher
    Fatty acid-binding protein-7 (FABP7) has been shown to be expressed in cutaneous melanoma; however, its role in tumor progression is unclear...
  17. Slipicevic A, Jørgensen K, Skrede M, Rosnes A, Trøen G, Davidson B, et al. The fatty acid binding protein 7 (FABP7) is involved in proliferation and invasion of melanoma cells. BMC Cancer. 2008;8:276 pubmed publisher
    ..of the new candidates that emerged from a recent gene expression profiling study is fatty acid-binding protein 7 (FABP7), involved in lipid metabolism, gene regulation, cell growth and differentiation...
  18. Iwayama Y, Hattori E, Maekawa M, Yamada K, Toyota T, Ohnishi T, et al. Association analyses between brain-expressed fatty-acid binding protein (FABP) genes and schizophrenia and bipolar disorder. Am J Med Genet B Neuropsychiatr Genet. 2010;153B:484-493 pubmed publisher
    ..PPI-controlling mechanisms, we previously performed quantitative trait loci (QTL) analysis in mice, and identified Fabp7, that encodes a brain-type fatty acid binding protein (Fabp), as a causative gene...
  19. Liang Y, Bollen A, Aldape K, Gupta N. Nuclear FABP7 immunoreactivity is preferentially expressed in infiltrative glioma and is associated with poor prognosis in EGFR-overexpressing glioblastoma. BMC Cancer. 2006;6:97 pubmed
    We previously identified brain type fatty acid-binding protein (FABP7) as a prognostic marker for patients with glioblastoma (GBM). Increased expression of FABP7 is associated with reduced survival...
  20. Balendiran G, Schnutgen F, Scapin G, Borchers T, Xhong N, Lim K, et al. Crystal structure and thermodynamic analysis of human brain fatty acid-binding protein. J Biol Chem. 2000;275:27045-54 pubmed
  21. Eggers M, Koburger Janssen T, Eickmann M, Zorn J. In Vitro Bactericidal and Virucidal Efficacy of Povidone-Iodine Gargle/Mouthwash Against Respiratory and Oral Tract Pathogens. Infect Dis Ther. 2018;7:249-259 pubmed publisher
    ..23% PVP-I and may provide a protective oropharyngeal hygiene measure for individuals at high risk of exposure to oral and respiratory pathogens. Mundipharma Research GmbH & Co. KG (MRG).
  22. Segura M, Demmelmair H, Krauss Etschmann S, Nathan P, Dehmel S, Padilla M, et al. Maternal BMI and gestational diabetes alter placental lipid transporters and fatty acid composition. Placenta. 2017;57:144-151 pubmed publisher
    ..Placental mRNA expression of FA transport proteins (FATP1, FATP4, FATP6), FA binding proteins (FABP3, FABP4, FABP7), FA translocase (FAT/CD36) and enzymes (Endothelial lipase (EL) and lipoprotein lipase (LPL)) were quantified by ..
  23. Xing L, McDonald H, Da Fonte D, Gutierrez Villagomez J, Trudeau V. Dopamine D1 receptor activation regulates the expression of the estrogen synthesis gene aromatase B in radial glial cells. Front Neurosci. 2015;9:310 pubmed publisher
    ..retain their major characteristics in vivo, including expression of glial fibrillary acidic protein and brain lipid binding protein. The estrogen synthesis enzyme aromatase B is exclusively found in RGCs, but this is lost as cells ..
  24. Schröder W, Alique M, Herrero J. Effects of the mas-related gene (Mrg) C receptor agonist BAM6-22 on nociceptive reflex activity in naive, monoarthritic and mononeuropathic rats after intraplantar and intrathecal administration. Eur J Pharmacol. 2016;770:147-53 pubmed publisher
  25. Sun Y, Jiang M, Hou B, Lu C, Lei Y, Ma Z, et al. Mas-Related Gene (Mrg) C Activation Attenuates Bone Cancer Pain via Modulating Gi and NR2B. PLoS ONE. 2016;11:e0154851 pubmed publisher
    This study is to investigate the role of Mas-related gene (Mrg) C in the pathogenesis and treatment of bone cancer pain (BCP). BCP mouse model was established by osteosarcoma cell inoculation...
  26. Burapan S, Kim M, Han J. Demethylation of Polymethoxyflavones by Human Gut Bacterium, Blautia sp. MRG-PMF1. J Agric Food Chem. 2017;65:1620-1629 pubmed publisher
  27. Ortega J, Suarez A, Serrano M, Baptista J, Pujol F, Rangel H. The role of the glycosyl moiety of myricetin derivatives in anti-HIV-1 activity in vitro. AIDS Res Ther. 2017;14:57 pubmed publisher
    ..with an EC50 of 120 µM for myricetin 3-rhamnoside (MR) and 45 µM for myricetin 3-(6-rhamnosylgalactoside) (MRG), both significantly lower than the EC50 of myricetin (230 µM)...
  28. Takaoka N, Takayama T, Ozono S. Functional analysis of fatty acid binding protein 7 and its effect on fatty acid of renal cell carcinoma cell lines. BMC Cancer. 2017;17:192 pubmed publisher
    Renal cell carcinomas (RCCs) overexpress fatty acid binding protein 7 (FABP7)...
  29. Matsue K, Minakawa S, Kashiwagi T, Toda K, Sato T, Shioda S, et al. Dentate granule progenitor cell properties are rapidly altered soon after birth. Brain Struct Funct. 2018;223:357-369 pubmed publisher
    ..The embryonic neocortex has radial glia or progenitor cells expressing brain lipid-binding protein (BLBP), whereas the adult hippocampus has radial granule progenitor cells expressing BLBP and glial fibrillary acidic ..
  30. Gao J, Ruan H, Qi X, Tao Y, Guo X, Shen W. HDAC3 But not HDAC2 Mediates Visual Experience-Dependent Radial Glia Proliferation in the Developing Xenopus Tectum. Front Cell Neurosci. 2016;10:221 pubmed
    ..and HDAC3 expression were developmentally regulated in tectal cells, especially in the ventricular layer of the BLBP-positive RGs...
  31. Hubert A, Henderson J, Cowles M, Ross K, Hagen M, Anderson C, et al. A functional genomics screen identifies an Importin-α homolog as a regulator of stem cell function and tissue patterning during planarian regeneration. BMC Genomics. 2015;16:769 pubmed publisher
    ..Along with five previously characterized genes (Smed-cycD, Smed-morf41/mrg-1, Smed-pdss2/dlp1, Smed-slbp, and Smed-tph), we identified 20 additional genes necessary for stem cell maintenance ..
  32. Hall V, Lindblad M, Jakobsen J, Gunnarsson A, Schmidt M, Rasmussen M, et al. Impaired APP activity and altered Tau splicing in embryonic stem cell-derived astrocytes obtained from an APPsw transgenic minipig. Dis Model Mech. 2015;8:1265-78 pubmed publisher
    ..These cells were confirmed to co-express varying neural markers, including NES, GFAP and BLBP, typical of type one radial glial cells (RGs) from the subgranular zone...
  33. Gerstner J, Perron I, Riedy S, Yoshikawa T, Kadotani H, Owada Y, et al. Normal sleep requires the astrocyte brain-type fatty acid binding protein FABP7. Sci Adv. 2017;3:e1602663 pubmed publisher
    ..The mammalian brain-type fatty acid binding protein (Fabp7) is expressed in astrocytes, and its mRNA oscillates in tandem with the sleep-wake cycle...
  34. Peng M, Li Z, Zhou N, Ma M, Jiang Y, Dong A, et al. Linking PHYTOCHROME-INTERACTING FACTOR to Histone Modification in Plant Shade Avoidance. Plant Physiol. 2018;176:1341-1351 pubmed publisher
    ..Here, we identify the H3K4me3/H3K36me3-binding proteins, Morf Related Gene (MRG) group proteins MRG1 and MRG2, as positive regulators of shade-induced hypocotyl elongation in Arabidopsis (..
  35. Zaganelli S, Rebelo Guiomar P, Maundrell K, Rozanska A, Pierredon S, Powell C, et al. The Pseudouridine Synthase RPUSD4 Is an Essential Component of Mitochondrial RNA Granules. J Biol Chem. 2017;292:4519-4532 pubmed publisher
    ..Here, we have applied a microscopy-based approach that has allowed us to identify novel components of the MRG proteome...
  36. Sürer Budak E, Toptas T, Aydin F, Oner A, Cevikol C, Simsek T. Correlation of Minimum Apparent Diffusion Coefficient and Maximum Standardized Uptake Value of the Primary Tumor with Clinicopathologic Characteristics in Endometrial Cancer. Mol Imaging Radionucl Ther. 2017;26:24-32 pubmed publisher
    ..emisyon tomografisi/bilgisayarl? tomografi (PET/BT) ve difüzyon a??rl?kl?-manyetik rezonans görüntüleme (DA-MRG) ile preoperatif de?erlendirmeyi takiben evreleme cerrahisi yap?lan toplamda 45 hasta, planl? veri toplama yap?lan ..
  37. Patel N, Mian M, Stafford R, Nahed B, Willie J, Gross R, et al. Laser Interstitial Thermal Therapy Technology, Physics of Magnetic Resonance Imaging Thermometry, and Technical Considerations for Proper Catheter Placement During Magnetic Resonance Imaging-Guided Laser Interstitial Thermal Therapy. Neurosurgery. 2016;79 Suppl 1:S8-S16 pubmed
    ..b>MRg-LITT, magnetic resonance-guided laser-induced thermal therapyPAD, precision aiming device.
  38. Li X, Li F, Liu J, Wang Y, Fu W. [Effect of antepartum taurine supplementation in regulating the activity of Rho family factors and promoting the proliferation of neural stem cells in neonatal rats with fetal growth restriction]. Zhongguo Dang Dai Er Ke Za Zhi. 2016;18:1158-1165 pubmed
    ..measure the expression of the specific intracellular markers for neural stem cells fatty acid binding protein 7 (FABP7), Rho-associated coiled-coil containing protein kinase 2 (ROCK2), ras homolog gene family, member A (RhoA), and ..
  39. Compagno M, Gullstrand B, Jacobsen S, Eilertsen G, Nilsson J, Lood C, et al. The assessment of serum-mediated phagocytosis of necrotic material by polymorphonuclear leukocytes to diagnose and predict the clinical features of systemic lupus erythematosus: an observational longitudinal study. Arthritis Res Ther. 2016;18:44 pubmed publisher
    ..by cross-sectional assessment of blood samples from 148 healthy control subjects and a multicenter rheumatic group (MRG) of 529 patients with different rheumatic symptoms...
  40. Nicola Z, Fabel K, Kempermann G. Development of the adult neurogenic niche in the hippocampus of mice. Front Neuroanat. 2015;9:53 pubmed publisher
    ..We used markers most relevant to adult neurogenesis research to describe this transition: Nestin, Sox2, BLBP, GFAP, Tbr2, Doublecortin (DCX), NeuroD1 and Prox1...
  41. Ä°dilman Ä, Gümrük F, HaliloÄŸlu M, Karçaaltıncaba M. The Feasibility of Magnetic Resonance Imaging for Quantification of Liver, Pancreas, Spleen, Vertebral Bone Marrow, and Renal Cortex R2* and Proton Density Fat Fraction in Transfusion-Related Iron Overload. Turk J Haematol. 2016;33:21-7 pubmed publisher
    ..kemik iliği ve böbrek korteksi R2* ve manyetik rezonans görüntüleme-proton dansite yağ oranı (MRG-PDYO) ölçümünün uygulanabilirliği ve bunlar arasındaki ilişkiyi değerlendirmeyi amaç..
  42. Taboada X, Viñas A, Adrio F. Comparative expression patterns of Sox2 and Sox19 genes in the forebrain of developing and adult turbot (Scophthalmus maximus). J Comp Neurol. 2017;: pubmed publisher
    ..relation between Sox expression and cell proliferation using series double immunostained for a radial glial marker (BLBP) and cell proliferation marker (PCNA)...
  43. Mang G, La Spada F, Emmenegger Y, Chappuis S, Ripperger J, Albrecht U, et al. Altered Sleep Homeostasis in Rev-erbα Knockout Mice. Sleep. 2016;39:589-601 pubmed publisher
    ..Lack of Rev-erbα increased Bmal1, Npas2, Clock, and Fabp7 expression, confirming the direct regulation of these genes by REV-ERBα also in the brain...
  44. Wan S, Lee H, Huang X, Xu T, Xu T, Zeng X, et al. Integrated local binary pattern texture features for classification of breast tissue imaged by optical coherence microscopy. Med Image Anal. 2017;38:104-116 pubmed publisher
    ..classification accuracy, we propose novel variants of LBP features, namely average LBP (ALBP) and block based LBP (BLBP)...
  45. Kaczocha M, Glaser S, Maher T, Clavin B, Hamilton J, O Rourke J, et al. Fatty acid binding protein deletion suppresses inflammatory pain through endocannabinoid/N-acylethanolamine-dependent mechanisms. Mol Pain. 2015;11:52 pubmed publisher
    ..Potential analgesic effects in mice lacking FABPs, however, have not been tested. Mice lacking FABP5 and FABP7, which exhibit highest affinities for endocannabinoids, possessed elevated levels of the endocannabinoid ..
  46. Zhang Y, Wang K, Lin M, Li Q, Hong Y. Inhibition of morphine tolerance by MrgC receptor via modulation of interleukin-1β and matrix metalloproteinase 9 in dorsal root ganglia in rats. Eur J Pharmacol. 2017;815:10-17 pubmed publisher
    Opiate tolerance is a critical issue in pain management. Previous studies show that activation of Mas-related gene (Mrg) C receptor can modulate the development of morphine tolerance...
  47. Young J, Baker J, Muller T. Immunoreactivity for brain-fatty acid binding protein in gomori-positive astrocytes. Glia. 1996;16:218-26 pubmed
    ..These data suggest that GP astrocytes have an unusual lipid metabolism, which may relate to degenerative processes occurring in the selected brain regions that contain GP astrocytes. ..
  48. Buchner A, Castro M, Hennig A, Popp T, Assmann G, Hofstetter A, et al. [Transcriptome analyses in renal cell carcinoma. Combination of laser microdissection and microarrays]. Urologe A. 2007;46:1170-5 pubmed
    ..Upregulation of FABP7 was confirmed by quantitative RT-PCR...
  49. Keilani S, Sugaya K. Reelin induces a radial glial phenotype in human neural progenitor cells by activation of Notch-1. BMC Dev Biol. 2008;8:69 pubmed publisher
    ..and Notch-1 signaling pathways have been recently found to be necessary to induce the expression of brain lipid binding protein (BLBP) and to promote the process extension and the maturation of the neuronal progenitors, the radial ..
  50. Pahari D, Gu Y, van Oeveren W, El Essawi A, Harringer W, Brouwer R. Effect of minimized perfusion circuit on brain injury markers carnosinase and brain-type fatty binding protein in coronary artery bypass grafting patients. Artif Organs. 2013;37:128-35 pubmed publisher
    ..Except endothelin-1 and leukocyte count, the inflammatory response of the MPC and CCPB was equal. ..
  51. Wang M, Liu Y, Goldberg I, Shi Y. Induction of mammary gland differentiation in transgenic mice by the fatty acid-binding protein MRG. J Biol Chem. 2003;278:47319-25 pubmed
    A mammary-derived growth inhibitor-related gene (MRG) was previously identified and characterized. MRG induces differentiation of mammary epithelial cells in vitro and its expression is associated with mammary differentiation...
  52. Tani G, Tomuschat C, O Donnell A, Coyle D, Puri P. Increased population of immature enteric glial cells in the resected proximal ganglionic bowel of Hirschsprung's disease patients. J Surg Res. 2017;218:150-155 pubmed publisher
    ..Fatty acid-binding protein 7 (FABP7) is a marker of immature enteric glial cells, whereas S100 is expressed only by mature glial cells...
  53. Rademacher M, Zimmerman A, Rüterjans H, Veerkamp J, Lücke C. Solution structure of fatty acid-binding protein from human brain. Mol Cell Biochem. 2002;239:61-8 pubmed
    ..Moreover, the NMR data indicate a close structural relationship between human B-FABP and heart-type FABP with respect to fatty acid binding inside the protein cavity. ..
  54. Li H, Yang Q, Han X, Tan X, Qin J, Jin G. Low-dose DHA-induced astrocyte proliferation can be attenuated by insufficient expression of BLBP in vitro. Prostaglandins Other Lipid Mediat. 2018;134:114-122 pubmed publisher
    ..b>Brain lipid binding protein (BLBP) exhibits a high affinity for n-3 PUFAs, especially DHA, but the precise functional contributions ..
  55. Laprairie R, Denovan Wright E, Wright J. Differential regulation of the duplicated fabp7, fabp10 and fabp11 genes of zebrafish by peroxisome proliferator activated receptors. Comp Biochem Physiol B Biochem Mol Biol. 2017;213:81-90 pubmed publisher
    ..This work provides a framework to account for the evolutionary trajectories that led to the high retention (57%) of duplicated fabp genes in the zebrafish genome compared to only ~3% of all duplicated genes in the zebrafish genome. ..
  56. Almberg K, Cohen R, Blackley D, Laney A, Storey E, Halldin C. Linking Compensation and Health Surveillance Data Sets to Improve Knowledge of US Coal Miners' Health. J Occup Environ Med. 2017;59:930-934 pubmed publisher
    Increase knowledge of US coal miners' respiratory health by linking data from the black lung benefits program (BLBP) and the coal workers' health surveillance program (CWHSP)...
  57. Wagner A, Stumbaugh A, Tigue Z, Edmondson J, Paquet A, Farmer D, et al. Genetic analysis of congenital cystic adenomatoid malformation reveals a novel pulmonary gene: fatty acid binding protein-7 (brain type). Pediatr Res. 2008;64:11-6 pubmed publisher
    ..Decreased expression of FABP-7 in fetal CCAM compared with normal fetal lung at both the RNA and protein levels suggests FABP-7 may have a role in pulmonary development and in the pathogenesis of CCAM. ..
  58. Teunissen C, Veerhuis R, de Vente J, Verhey F, Vreeling F, van Boxtel M, et al. Brain-specific fatty acid-binding protein is elevated in serum of patients with dementia-related diseases. Eur J Neurol. 2011;18:865-71 pubmed publisher
    ..In contrast to heart-type FABP, serum levels of brain-type FABP are elevated in a significant proportion of patients with various neurodegenerative diseases and can therefore have importance for defining subgroups of these patients. ..
  59. Han X, Li H, Zhang Y, Qin J, Yang Q, Wang L, et al. Brain lipid-binding protein promotes proliferation and modulates cell cycle in C6 rat glioma cells. Int J Oncol. 2017;51:1439-1448 pubmed publisher
    ..Four grades of gliomas have been identified, namely, grades I-IV. Brain lipid-binding protein (BLBP), which functions in the intracellular transport of fatty acids, is expressed in all grades of human gliomas...
  60. Morihiro Y, Yasumoto Y, Vaidyan L, Sadahiro H, Uchida T, Inamura A, et al. Fatty acid binding protein 7 as a marker of glioma stem cells. Pathol Int. 2013;63:546-53 pubmed publisher
    ..Fatty acid binding protein 7 (FABP7), which is a cellular chaperone for a variety of omega-3 fatty acids, is a known marker for neural stem cells...
  61. Ju Lee H, Bartsch D, Xiao C, Guerrero S, Ahuja G, Schindler C, et al. A post-transcriptional program coordinated by CSDE1 prevents intrinsic neural differentiation of human embryonic stem cells. Nat Commun. 2017;8:1456 pubmed publisher
    ..Among these key pro-neural/neuronal factors, CSDE1 binds fatty acid binding protein 7 (FABP7) and vimentin (VIM) mRNAs, as well as transcripts involved in neuron projection development regulating their ..
  62. Dolagaratz Carricavur A, Chiodi Boudet L, Romero M, Polizzi P, Marcovecchio J, Gerpe M. Toxicological responses of Laeonereis acuta (Polychaeta, Nereididae) after acute, subchronic and chronic exposure to cadmium. Ecotoxicol Environ Saf. 2018;149:217-224 pubmed publisher
    ..Concentrations of metallothioneins (MT), lipid peroxidation (LPO), total Cd and metal-rich granules (MRG) were evaluated. Seasonal variations of MT and LPO levels in the wild were also measured...
  63. Wang W, Su Z, Chen D, Mi J, Gao H. Differential expressions of BMPR1?, ACTN4? and FABP7 in Hirschsprung disease. Int J Clin Exp Pathol. 2014;7:2312-8 pubmed
    ..bone morphogenetic protein receptor-type IA (BMPR1?), actinin-alpha 4 (ACTN4?) and fatty acid binding protein 7 (FABP7) play important roles in the differentiation and development of neurons...
  64. Hartfuss E, Galli R, Heins N, Gotz M. Characterization of CNS precursor subtypes and radial glia. Dev Biol. 2001;229:15-30 pubmed
    ..for the antigens RC2, the astrocyte-specific glutamate transporter (GLAST), and the brain-lipid-binding protein (BLBP)...
  65. Pu L, Igbavboa U, Wood W, Roths J, Kier A, Spener F, et al. Expression of fatty acid binding proteins is altered in aged mouse brain. Mol Cell Biochem. 1999;198:69-78 pubmed
    ..Age differences in brain H-FABP and B-FABP levels in synaptosomal plasma membranes and synaptosomal cytosol may be important factors modulating neuronal differentiation and function. ..
  66. Le Dantec C, Vallet S, Brooks W, Renaudineau Y. Human endogenous retrovirus group E and its involvement in diseases. Viruses. 2015;7:1238-57 pubmed publisher
    ..Finally, better understanding of HERV-E elements may have clinical applications for prevention, diagnosis, prognosis, and therapy. ..
  67. Zachiu C, Denis de Senneville B, Dmitriev I, Moonen C, Ries M. A framework for continuous target tracking during MR-guided high intensity focused ultrasound thermal ablations in the abdomen. J Ther Ultrasound. 2017;5:27 pubmed publisher
    During lengthy magnetic resonance-guided high intensity focused ultrasound (MRg-HIFU) thermal ablations in abdominal organs, the therapeutic work-flow is frequently hampered by various types of physiological motion occurring at different ..
  68. Kommata V, Dermon C. Transient vimentin expression during the embryonic development of the chicken cerebellum. Int J Dev Neurosci. 2018;65:11-20 pubmed publisher
    ..Vimentin expression showed partial co-localization with the glial markers GFAP and BLBP. Within cerebellar cortex, vimentin+ fibers were first found within lobules I and X (E10) and gradually extended to ..
  69. Borchers T, Hohoff C, Buhlmann C, Spener F. Heart-type fatty acid binding protein - involvement in growth inhibition and differentiation. Prostaglandins Leukot Essent Fatty Acids. 1997;57:77-84 pubmed
    ..This argues against an active role of H-FABP in muscle development unlike the situation in the mammary gland. ..
  70. Karvellas C, Speiser J, Tremblay M, Lee W, Rose C. The association between FABP7 serum levels with survival and neurological complications in acetaminophen-induced acute liver failure: a nested case-control study. Ann Intensive Care. 2017;7:99 pubmed publisher
    ..Brain-type fatty acid-binding protein (FABP7) is a small (15 kDa) cytoplasmic protein abundantly expressed in astrocytes...
  71. Geller S, Lomet D, Caraty A, Tillet Y, Duittoz A, Vaudin P. Rostro-caudal maturation of glial cells in the accessory olfactory system during development: involvement in outgrowth of GnRH neurites. Eur J Neurosci. 2017;46:2596-2607 pubmed publisher
    ..The OEC progenitors immunoreactive to brain lipid binding protein formed the microenvironment of migrating GnRH neurones from the vomeronasal organ to the telencephalon ..
  72. Li H, Lu Q, Dong L, Xue H, Zhou H, Yang H. [Expression of fatty acid binding protein in human breast cancer tissues]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2007;23:312-6 pubmed
    ..E-, L-, and H-FABP may play a key role in the progress of invasiveness and metastasis in human breast cancer. Furthermore, the secretion of these FABPs has the potential to serve as a diagnostic marker for breast cancer. ..
  73. Sharifi K, Ebrahimi M, Kagawa Y, Islam A, Tuerxun T, Yasumoto Y, et al. Differential expression and regulatory roles of FABP5 and FABP7 in oligodendrocyte lineage cells. Cell Tissue Res. 2013;354:683-95 pubmed publisher
    ..We evaluate the in vivo and in vitro expression of FABP5 and FABP7 in oligodendrocyte lineage cells in the cortex and corpus callosum of adult mice, mixed cortical culture and ..
  74. Li L, Xia Y, Zhang T. Co-occurrence of antibiotic and metal resistance genes revealed in complete genome collection. ISME J. 2017;11:651-662 pubmed publisher
    ..Given the lack of comprehensive understanding of the ARG and MRG coselection, in this study both abundance relationship and genetic linkage between ARGs and MRGs were rigorously ..
  75. Schnell A, Chappuis S, Schmutz I, Brai E, Ripperger J, Schaad O, et al. The nuclear receptor REV-ERB? regulates Fabp7 and modulates adult hippocampal neurogenesis. PLoS ONE. 2014;9:e99883 pubmed publisher
    ..We identified fatty acid binding protein 7 (Fabp7, Blbp) as a direct target of repression by REV-ERB?...
  76. Lock F, Rebollo R, Miceli Royer K, Gagnier L, Kuah S, Babaian A, et al. Distinct isoform of FABP7 revealed by screening for retroelement-activated genes in diffuse large B-cell lymphoma. Proc Natl Acad Sci U S A. 2014;111:E3534-43 pubmed publisher
    ..We further characterized a TE-gene chimeric transcript involving a fatty acid-binding protein gene (LTR2-FABP7), normally expressed in brain, that was ectopically expressed in a subset of DLBCL patients through the use of an ..
  77. Seeger D, Murphy C, Murphy E. Astrocyte arachidonate and palmitate uptake and metabolism is differentially modulated by dibutyryl-cAMP treatment. Prostaglandins Leukot Essent Fatty Acids. 2016;110:16-26 pubmed publisher
    ..However, expression of Fabp5 and Fabp7 were significantly reduced by 25% and 45%, respectively...
  78. Zhou J, Deng Z, Chen Y, Gao Y, Wu D, Zhu G, et al. Overexpression of FABP7 promotes cell growth and predicts poor prognosis of clear cell renal cell carcinoma. Urol Oncol. 2015;33:113.e9-17 pubmed publisher
    ..7, in ccRCC and matched normal kidney samples was verified by immunohistochemistry and the association between FABP7 level and patient survival was investigated...