FABP7

Summary

Gene Symbol: FABP7
Description: fatty acid binding protein 7
Alias: B-FABP, BLBP, FABPB, MRG, fatty acid-binding protein, brain, brain lipid-binding protein, brain-type fatty acid-binding protein, mammary-derived growth inhibitor-related
Species: human

Top Publications

  1. pmc Reelin induces a radial glial phenotype in human neural progenitor cells by activation of Notch-1
    Serene Keilani
    Biomolecular Science Center, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, 4000 Central Florida Blvd, Orlando, FL 32816 2364, USA
    BMC Dev Biol 8:69. 2008
  2. ncbi Ligand specificity of brain lipid-binding protein
    L Z Xu
    Howard Hughes Medical Institute, Laboratory of Molecular Biology, The Rockefeller University, New York, New York 10021 6399, USA
    J Biol Chem 271:24711-9. 1996
  3. ncbi Isolation and expression of a cDNA for human brain fatty acid-binding protein (B-FABP)
    F Shimizu
    Otsuka GEN Research Institute, Otsuka Pharmaceutical Co, Ltd, Tokushima, Japan
    Biochim Biophys Acta 1354:24-8. 1997
  4. ncbi Crystal structure and thermodynamic analysis of human brain fatty acid-binding protein
    G K Balendiran
    Department of Biochemistry and Biophysics, Texas A and M University, College Station, Texas 77843 2128, USA
    J Biol Chem 275:27045-54. 2000
  5. pmc Brain lipid binding protein in axon-Schwann cell interactions and peripheral nerve tumorigenesis
    Shyra J Miller
    Department of Cell Biology, Neurobiology and Anatomy, University of Cincinnati College of Medicine, 231 Bethesda Avenue, Cincinnati, OH 45267 0521, USA
    Mol Cell Biol 23:2213-24. 2003
  6. pmc Overexpression of FABP7 in Down syndrome fetal brains is associated with PKNOX1 gene-dosage imbalance
    Ma Francisca Sánchez-Font
    Departament de Genetica, Facultat de Biologia, Universitat de Barcelona, Avda Diagonal, 645, E 08028 Barcelona, Spain
    Nucleic Acids Res 31:2769-77. 2003
  7. pmc Gene expression profiling reveals molecularly and clinically distinct subtypes of glioblastoma multiforme
    Yu Liang
    Preuss Laboratory for Molecular Neuro oncology and Department of Neurological Surgery, University of California San Francisco, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 102:5814-9. 2005
  8. pmc Brain lipid-binding protein is a direct target of Notch signaling in radial glial cells
    Todd E Anthony
    Laboratory of Molecular Biology, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
    Genes Dev 19:1028-33. 2005
  9. pmc Analysis of differential gene expression in human melanocytic tumour lesions by custom made oligonucleotide arrays
    N J W de Wit
    Department of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Br J Cancer 92:2249-61. 2005
  10. ncbi FABP7 expression in glioblastomas: relation to prognosis, invasion and EGFR status
    Gentian Kaloshi
    Service de Neurologie Mazarin, Assistance Publique Hopitaux de Paris, Groupe Hospitalier Pitie Salpetriere, and INSERM, U711, Biologie des Interactions Neurones and Glie, Faculte de Medecine, Universite Pierre et Marie Curie, Paris, Cedex 13, 75651, France
    J Neurooncol 84:245-8. 2007

Research Grants

  1. Transcription factors regulating sensory gene expression and pain pathways
    Eric E Turner; Fiscal Year: 2011
  2. Dale G Deutsch; Fiscal Year: 2016
  3. Anandamide Carrier Proteins as Drug Targets
    Jason Jianxin Guo; Fiscal Year: 2013
  4. Role of the Mrg family of GPCRs in nociception
    David Anderson; Fiscal Year: 2009
  5. MR-guided focused ultrasound system
    Fergus V Coakley; Fiscal Year: 2010
  6. FREQUENCY DOMAIN OPTICAL IMAGING OF BREAST CANCER
    Keith D Paulsen; Fiscal Year: 2012
  7. Regulation of Hepatic Repair Response by Metabolites of the Uric Acid Pathway
    Wajahat Zafar Mehal; Fiscal Year: 2013
  8. A screen for small molecule modulators of human GPCR MrgX1
    Xinzhong Dong; Fiscal Year: 2012
  9. MAST CELL NERVE INTERACTIONS IN AIRWAYS
    Bradley J Undem; Fiscal Year: 2010
  10. Riparian nutrients and food webs on a regulated river
    TERESA TIBBETS; Fiscal Year: 2005

Detail Information

Publications231 found, 100 shown here

  1. pmc Reelin induces a radial glial phenotype in human neural progenitor cells by activation of Notch-1
    Serene Keilani
    Biomolecular Science Center, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, 4000 Central Florida Blvd, Orlando, FL 32816 2364, USA
    BMC Dev Biol 8:69. 2008
    ..and Notch-1 signaling pathways have been recently found to be necessary to induce the expression of brain lipid binding protein (BLBP) and to promote the process extension and the maturation of the neuronal progenitors, the radial ..
  2. ncbi Ligand specificity of brain lipid-binding protein
    L Z Xu
    Howard Hughes Medical Institute, Laboratory of Molecular Biology, The Rockefeller University, New York, New York 10021 6399, USA
    J Biol Chem 271:24711-9. 1996
    Brain lipid-binding protein (BLBP) is a member of the fatty acid-binding protein (FABP) family...
  3. ncbi Isolation and expression of a cDNA for human brain fatty acid-binding protein (B-FABP)
    F Shimizu
    Otsuka GEN Research Institute, Otsuka Pharmaceutical Co, Ltd, Tokushima, Japan
    Biochim Biophys Acta 1354:24-8. 1997
    ..The elevated level of transcript at immature stages and its subsequent decline In adult brain indicate that the encoded protein may be essential for development of the human brain...
  4. ncbi Crystal structure and thermodynamic analysis of human brain fatty acid-binding protein
    G K Balendiran
    Department of Biochemistry and Biophysics, Texas A and M University, College Station, Texas 77843 2128, USA
    J Biol Chem 275:27045-54. 2000
    ....
  5. pmc Brain lipid binding protein in axon-Schwann cell interactions and peripheral nerve tumorigenesis
    Shyra J Miller
    Department of Cell Biology, Neurobiology and Anatomy, University of Cincinnati College of Medicine, 231 Bethesda Avenue, Cincinnati, OH 45267 0521, USA
    Mol Cell Biol 23:2213-24. 2003
    ..Using cDNA microarrays, we found that brain lipid binding protein (BLBP) is elevated in an EGFR-positive subpopulation of Nf1 mutant mouse Schwann cells (Nf1(-/-) TXF) ..
  6. pmc Overexpression of FABP7 in Down syndrome fetal brains is associated with PKNOX1 gene-dosage imbalance
    Ma Francisca Sánchez-Font
    Departament de Genetica, Facultat de Biologia, Universitat de Barcelona, Avda Diagonal, 645, E 08028 Barcelona, Spain
    Nucleic Acids Res 31:2769-77. 2003
    ..subtractive hybridization performed on Down syndrome (DS) fetal brains revealed a differentially expressed gene, FABP7, mapped to 6q22-23. FABP7 overexpression in DS brains was verified by real-time PCR (1.63-fold)...
  7. pmc Gene expression profiling reveals molecularly and clinically distinct subtypes of glioblastoma multiforme
    Yu Liang
    Preuss Laboratory for Molecular Neuro oncology and Department of Neurological Surgery, University of California San Francisco, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 102:5814-9. 2005
    ..We further investigated one gene from the group, FABP7, and confirmed its association with survival in two unrelated cohorts totaling 105 patients...
  8. pmc Brain lipid-binding protein is a direct target of Notch signaling in radial glial cells
    Todd E Anthony
    Laboratory of Molecular Biology, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
    Genes Dev 19:1028-33. 2005
    ..To elucidate pathways involved in these functions, we mapped in vivo the promoter for Blbp, a radial glial gene...
  9. pmc Analysis of differential gene expression in human melanocytic tumour lesions by custom made oligonucleotide arrays
    N J W de Wit
    Department of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Br J Cancer 92:2249-61. 2005
    ..For at least nine of these genes, namely THBD, FABP7, H2AFJ, RRAGD, MYADM, HR, CKS2, NCK2 and GDF15, the differential expression found by array analyses could be ..
  10. ncbi FABP7 expression in glioblastomas: relation to prognosis, invasion and EGFR status
    Gentian Kaloshi
    Service de Neurologie Mazarin, Assistance Publique Hopitaux de Paris, Groupe Hospitalier Pitie Salpetriere, and INSERM, U711, Biologie des Interactions Neurones and Glie, Faculte de Medecine, Universite Pierre et Marie Curie, Paris, Cedex 13, 75651, France
    J Neurooncol 84:245-8. 2007
    b>FABP7 expression has been analysed in a series of 123 glioblastomas (68 pure GBM, 55 GBMO, i.e. with oligodendroglial component)...
  11. pmc B-FABP-expressing radial glial cells: the malignant glioma cell of origin?
    Raja Mita
    Department of Oncology, University of Alberta, Cross Cancer Institute, Edmonton, Alberta, Canada
    Neoplasia 9:734-44. 2007
    ..Thus, targeting B-FABP-expressing cells may make a significant impact on the treatment of these tumors...
  12. pmc The fatty acid binding protein 7 (FABP7) is involved in proliferation and invasion of melanoma cells
    Ana Slipicevic
    Pathology Clinic, Rikshospitalet Radiumhospitalet Medical Center, Montebello N 0310 Oslo, Norway
    BMC Cancer 8:276. 2008
    ..One of the new candidates that emerged from a recent gene expression profiling study is fatty acid-binding protein 7 (FABP7), involved in lipid metabolism, gene regulation, cell growth and differentiation.
  13. doi Nuclear factor I regulates brain fatty acid-binding protein and glial fibrillary acidic protein gene expression in malignant glioma cell lines
    Miranda Brun
    Department of Oncology, Cross Cancer Institute, University of Alberta, Alberta, Canada
    J Mol Biol 391:282-300. 2009
    ..normally found in astrocytes, and the radial glial marker brain fatty acid-binding protein (B-FABP; also known as FABP7) are co-expressed in malignant glioma cell lines and tumors...
  14. doi Association analyses between brain-expressed fatty-acid binding protein (FABP) genes and schizophrenia and bipolar disorder
    Yoshimi Iwayama
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako City, Saitama, Japan
    Am J Med Genet B Neuropsychiatr Genet 153:484-93. 2010
    ..PPI-controlling mechanisms, we previously performed quantitative trait loci (QTL) analysis in mice, and identified Fabp7, that encodes a brain-type fatty acid binding protein (Fabp), as a causative gene...
  15. doi The proteins FABP7 and OATP2 are associated with the basal phenotype and patient outcome in human breast cancer
    H Zhang
    Division of Pathology, School of Molecular Medical Sciences, Queen s Medical Centre, University of Nottingham, Nottingham, NG7 2UH, UK
    Breast Cancer Res Treat 121:41-51. 2010
    ..We analysed 48,000 gene transcripts in 132 invasive breast carcinomas to identify two novel genes (OATP2 and FABP7) significantly associated with BP [defined by cytokeratin (CK)5/6 and/or CK14 positivity]...
  16. doi Overexpression of fatty acid binding protein-7 correlates with basal-like subtype of breast cancer
    Xiao Yan Tang
    Department of Pathology, Tokai University School of Medicine, 143 Shimokasuya, Isehara City, Kanagawa 259 1193, Japan
    Pathol Res Pract 206:98-101. 2010
    ....
  17. pmc Brain-type and liver-type fatty acid-binding proteins: new tumor markers for renal cancer?
    Angelika Tölle
    Department of Urology, Charite Universitatsmedizin Berlin, Berlin, Germany
    BMC Cancer 9:248. 2009
    ..We examined the level of brain-type (B) and liver-type (L) FABP mRNA and the protein expression profiles of both FABPs in renal cell carcinoma...
  18. doi Polymorphism screening of brain-expressed FABP7, 5 and 3 genes and association studies in autism and schizophrenia in Japanese subjects
    Motoko Maekawa
    RIKEN Brain Science Institute, Saitama, Japan
    J Hum Genet 55:127-30. 2010
    ..protein (FABP) gene family encode fatty acid-binding proteins and consist of at least 12 members, of which FABP7, 5 and 3 are expressed in the brain...
  19. doi Fatty acid binding proteins in brain development and disease
    Rong Zong Liu
    Department of Oncology, University of Alberta, Edmonton, AB, Canada
    Int J Dev Biol 54:1229-39. 2010
    ..Three of the ten mammalian FABPs identified to date (FABP3, FABP5, FABP7) are expressed in the brain...
  20. doi Fatty acid binding protein 7 expression and its sub-cellular localization in breast cancer
    Alaa T Alshareeda
    Department of Histopathology and School of Molecular Medical Sciences, The University of Nottingham and Nottingham University Hospitals NHS Trust, Nottingham City Hospital, Nottingham, UK
    Breast Cancer Res Treat 134:519-29. 2012
    b>FABP7 is a member of the multi-gene fatty acid binding protein family...
  21. pmc Neural stem cell specific fluorescent chemical probe binding to FABP7
    Seong Wook Yun
    Laboratory of Bioimaging Probe Development, Singapore Bioimaging Consortium, Agency for Science, Technology and Research, Singapore
    Proc Natl Acad Sci U S A 109:10214-7. 2012
    ..its binding target by proteomic analysis as fatty acid binding protein 7 (FABP7), also known as brain lipid binding protein) which is highly expressed in neural stem cells and localized in the cytoplasm...
  22. pmc A radial glia gene marker, fatty acid binding protein 7 (FABP7), is involved in proliferation and invasion of glioblastoma cells
    Antonella De Rosa
    Siena Biotech SpA, Siena, Italy
    PLoS ONE 7:e52113. 2012
    ..Fatty acid-binding protein 7 (FABP7) was identified as one of the most highly expressed genes in NS compared to their adherent counterpart...
  23. ncbi Antitumor activity of the novel human breast cancer growth inhibitor, mammary-derived growth inhibitor-related gene, MRG
    Y E Shi
    Department of Pediatrics, Long Island Jewish Medical Center, The Long Island Campus for the Albert Einstein College of Medicine, New Hyde Park, New York 11040, USA
    Cancer Res 57:3084-91. 1997
    ..to mouse mammary-derived growth inhibitor and thus was named mammary-derived growth inhibitor-related gene (MRG). MRG was found to be expressed in normal and benign human breast tissues but not in breast carcinomas...
  24. ncbi Correlation of B-FABP and GFAP expression in malignant glioma
    R Godbout
    Department of Oncology, University of Alberta, Cross Cancer Institute, Edmonton, Canada
    Oncogene 16:1955-62. 1998
    ..We suggest that some malignant gliomas may be derived from astrocytic precursor cells which can express proteins that are normally produced at different developmental stages in the astrocytic differentiation pathway...
  25. pmc Nuclear FABP7 immunoreactivity is preferentially expressed in infiltrative glioma and is associated with poor prognosis in EGFR-overexpressing glioblastoma
    Yu Liang
    Department of Neurological Surgery, Brain Tumor Research Center, University of California, San Francisco, CA 94143, USA
    BMC Cancer 6:97. 2006
    We previously identified brain type fatty acid-binding protein (FABP7) as a prognostic marker for patients with glioblastoma (GBM). Increased expression of FABP7 is associated with reduced survival...
  26. pmc Aberrant fatty acid-binding protein-7 gene expression in cutaneous malignant melanoma
    Yasufumi Goto
    Department of Molecular Oncology, John Wayne Cancer Institute, Santa Monica, California, USA
    J Invest Dermatol 130:221-9. 2010
    Fatty acid-binding protein-7 (FABP7) has been shown to be expressed in cutaneous melanoma; however, its role in tumor progression is unclear...
  27. pmc Brain fatty acid-binding protein and omega-3/omega-6 fatty acids: mechanistic insight into malignant glioma cell migration
    Raja Mita
    Department of Oncology, School of Cancer, Engineering and Imaging Sciences, Cross Cancer Institute, University of Alberta, Edmonton, Alberta T6G 1Z2
    J Biol Chem 285:37005-15. 2010
    ..Brain fatty acid-binding protein (FABP7), which binds docosahexaenoic acid (DHA) and arachidonic acid (AA), localizes to sites of tumor infiltration and ..
  28. doi Importance of brain‑type fatty acid binding protein for cell-biological processes in human renal carcinoma cells
    Angelika Tölle
    Department of Urology, Charite Universitatsmedizin Berlin, Chariteplatz 1, D 10117 Berlin, Germany
    Oncol Rep 25:1307-12. 2011
    ..An effect on the process of invasion was not observed. Our data suggest that B‑FABP is involved in cell proliferation and migration of human renal carcinoma cells. The detailed molecular mechanisms remain to be elucidated...
  29. ncbi Microarray analysis in the HSV-1 latently infected mouse trigeminal ganglion
    Shiro Higaki
    Department of Ophthalmology, Kinki University School of Medicine, Osaka, Japan
    Cornea 23:S42-7. 2004
    ..To review our previous studies regarding alterations in gene expression in HSV-1 latently infected mouse trigeminal ganglia (TGs) following treatment with immunosuppressants and hyperthermia...
  30. ncbi Prevalence of fissured tongue, geographic tongue and median rhomboid glossitis among Israeli adults of different ethnic origins
    Noam Yarom
    Department of Oral Pathology and Oral Medicine, Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel
    Dermatology 209:88-94. 2004
    BACKGROUND: Fissured tongue (FT), geographic tongue (GT) and median rhomboid glossitis (MRG) are frequently misdiagnosed and overtreated...
  31. pmc Populations of radial glial cells respond differently to reelin and neuregulin1 in a ferret model of cortical dysplasia
    Sylvie Poluch
    Anatomy, Physiology, and Genetics, Uniformed Services University, Bethesda, Maryland, United States of America
    PLoS ONE 5:e13709. 2010
    ..Both reelin and neuregulin1 (NRG1) maintain the radial glial scaffold; they also induce expression of Brain Lipid Binding Protein (BLBP), a well known marker of radial glia...
  32. ncbi Improved outcome in childhood acute lymphoblastic leukemia despite reduced use of anthracyclines and cranial radiotherapy: results of trial ALL-BFM 90. German-Austrian-Swiss ALL-BFM Study Group
    M Schrappe
    Department of Pediatric Hematology and Oncology, Medizinische Hochschule Hannover, Federal Republic of Germany FRG
    Blood 95:3310-22. 2000
    ..Patients were stratified into a standard-risk group (SRG), a medium-risk group (MRG), both defined by adequate early treatment response; and a high-risk group (HRG), defined by inadequate response to ..
  33. ncbi Expression patterns of erythropoietin and its receptor in the developing midbrain
    W Knabe
    Department of Anatomy and Embryology, Georg August University, 37075 Gottingen, Germany
    Anat Embryol (Berl) 207:503-12. 2004
    ..Whether the observed expression patterns of EPO and EPOR may reflect EPO-mediated trophic and/or antiapoptotic effects on neurons is discussed...
  34. ncbi The expression pattern of a novel gene encoding brain-fatty acid binding protein correlates with neuronal and glial cell development
    A Kurtz
    Unit on Developmental Biology, National Institute of Mental Health, Bethesda, MD 20892
    Development 120:2637-49. 1994
    ....
  35. ncbi Developmental lineage of cell types in cortical dysplasia with balloon cells
    Phillip Lamparello
    PENN Epilepsy Center and Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA, USA
    Brain 130:2267-76. 2007
    ..of 13 antibodies recognizing proteins associated with (i) specific progenitor cell types including brain lipid binding protein (BLBP), collapsin response mediator protein 4 (CRMP4), Dlx1, Dlx2, GFAPdelta, MASH1, Otx1, Pax6, ..
  36. ncbi Interactions between the Mas-related receptors MrgD and MrgE alter signalling and trafficking of MrgD
    Sandra Milasta
    Molecular Pharmacology Group, Division of Biochemistry and Molecular Biology, Institute of Biomedical and Life Sciences, University of Glasgow, Scotland, UK
    Mol Pharmacol 69:479-91. 2006
    ..This is the first report of heterodimeric interactions between members of the Mas-related gene (Mrg) receptor family and indicates that interactions between rMrgD and rMrgE modulate the function of rMrgD...
  37. doi Chondroitin sulfates are required for fibroblast growth factor-2-dependent proliferation and maintenance in neural stem cells and for epidermal growth factor-dependent migration of their progeny
    Swetlana Sirko
    Cell Morphology and Molecular Neurobiology, Ruhr University Bochum, Universitaetsstrasse, Bochum, Germany
    Stem Cells 28:775-87. 2010
    ..Upon EGF treatment, fewer radial glia were brain lipid-binding protein (BLBP)-positive, whereas more were glutamate aspartate transporter (GLAST)-positive after CS-GAG removal...
  38. ncbi Regulation of two rat mas-related genes in a model of neuropathic pain
    Eric L Gustafson
    Department of Discovery Technologies, Schering Plough Research Institute, Kenilworth, NJ, USA
    Brain Res Mol Brain Res 142:58-64. 2005
    The mas-related gene (Mrg) family is a large family of G-protein-coupled receptors which are variable in number depending on species...
  39. ncbi [Comparison of the present and previously used protocol of risk stratification in children with acute lymphoblastic leukemia]
    Eliza Glodkowska
    Katedra i Klinika Hematologii i Onkologii, Akademia Medyczna, ul Marszałkowska 24, 00 576 Warszawa, Poland
    Med Wieku Rozwoj 11:153-8. 2007
    ..Acute lymphoblastic leukaemia (ALL) is one of the most common cancers in children. In Poland, since November 2002 a new protocol of risk stratification has been recommended for assessment of risk factors and for choosing therapy regimens...
  40. doi Organization of the human embryonic ventral mesencephalon
    Jenny Nelander
    Department of Experimental Medical Science and Lund Strategic Center for Stem Cell, Biology and Cell Therapy, Lund University, Sweden
    Gene Expr Patterns 9:555-61. 2009
    ..We report that BLBP and LMX1A mark the floor plate and that FOXA2 is expressed in both the floor plate and basal plate of the human VM...
  41. ncbi Cellular localization of the diazepam binding inhibitor in glial cells with special reference to its coexistence with brain-type fatty acid binding protein
    Haruko Yanase
    Laboratory of Anatomy, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    Arch Histol Cytol 65:27-36. 2002
    ....
  42. doi Immunochemical and molecular characterization of a novel cell line derived from the brain of Trachinotus blochii (Teleostei, Perciformes): A fish cell line with oligodendrocyte progenitor cell and tanycyte characteristics
    Chiu Ming Wen
    Department of Life Sciences, National University of Kaohsiung, Kaohsiung, Taiwan
    Comp Biochem Physiol A Mol Integr Physiol 156:224-31. 2010
    ..Fish tanycytes can be neural stem cells suggesting that SPB cells are neural stem cells. SPB is the first fish cell line showing primary cilia and markers for both OPCs and tanycytes...
  43. doi Congenital subependymal giant cell astrocytoma: clinical considerations and expression of radial glial cell markers in giant cells
    Ji Hoon Phi
    Division of Pediatric Neurosurgery, Seoul National University Children s Hospital, 101 Daehangno, Jongno gu, Seoul, 110 744, Republic of Korea
    Childs Nerv Syst 24:1499-503. 2008
    ..Previous studies have reported poor surgical outcomes of this small group of patients. We encountered a patient diagnosed as congenital SEGA and report the surgical outcome along with interesting immuno-phenotypes of giant tumor cells...
  44. doi Distribution of EFHC1 or Myoclonin 1 in mouse neural structures
    Christine Leon
    GIGA Neurosciences, University of Liege, Avenue de l Hopital 1, Liege, Belgium
    Epilepsy Res 88:196-207. 2010
    ..the pattern of expression seems to correspond to the extensions of the radial glia fibers as demonstrated by BLBP immunostaining...
  45. ncbi Rhomboid glossitis in atypical location: case report and differential diagnosis
    Lucía Lago-Méndez
    Cirugía Oral e Implantología, Universidad de Santiago de Compostela
    Med Oral Patol Oral Cir Bucal 10:123-7. 2005
    Median rhomboid glossitis (MRG) is an uncommon benign abnormality of the tongue, most frequently affecting men...
  46. ncbi Role of Fabp7, a downstream gene of Pax6, in the maintenance of neuroepithelial cells during early embryonic development of the rat cortex
    Yoko Arai
    Division of Developmental Neuroscience, Department of Functional Genomics, Center for Translational and Advanced Animal Research, Tohoku University School of Medicine, Sendai 980 8575, Japan
    J Neurosci 25:9752-61. 2005
    ..Here, we identified Fabp7 (BLBP/B-FABP), a member of the fatty acid-binding protein (FABP) family, as a downregulated gene in the embryonic ..
  47. doi Identification of testis-specific male contraceptive targets: insights from transcriptional profiling of the cycle of the rat seminiferous epithelium and purified testicular cells
    Daniel S Johnston
    Contraception, Women s Health and Musculoskeletal Biology, Wyeth Research
    Ann N Y Acad Sci 1120:36-46. 2007
    ..The microarray data and the qRT-PCR data described are available in the Mammalian Reproductive Genetics database (http://mrg.genetics.washington.edu/).
  48. ncbi Characterization of CNS precursor subtypes and radial glia
    E Hartfuss
    Max Planck Institute of Neurobiology, Am Klopferspitz 18a, Martinsried, D 82152, Germany
    Dev Biol 229:15-30. 2001
    ..for the antigens RC2, the astrocyte-specific glutamate transporter (GLAST), and the brain-lipid-binding protein (BLBP)...
  49. ncbi Astrogliosis in EAE spinal cord: derivation from radial glia, and relationships to oligodendroglia
    Peter Bannerman
    Institute for Pediatric Regenerative Research, UC Davis School of Medicine, Shriners Hospital for Children, Northern California, Sacramento, California 95817, USA
    Glia 55:57-64. 2007
    ..EAE) is the accumulation of enlarged, multipolar glial fibrillary acidic protein (GFAP) and brain lipid binding protein (BLBP) immunoreactive astroglia within and at the margins of the inflammatory demyelinative lesions...
  50. pmc Prediction of the 3-D structure of rat MrgA G protein-coupled receptor and identification of its binding site
    Jiyoung Heo
    Materials and Process Simulations Center, California Institute of Technology, Pasadena, CA 91125, USA
    J Mol Graph Model 26:800-12. 2007
    b>Mrg receptors are orphan G protein-coupled receptors (GPCRs) located mainly at the specific set of sensory neurons in the dorsal root ganglia, suggesting a role in nociception...
  51. ncbi Morphological characterization of rat Mas-related G-protein-coupled receptor C and functional analysis of agonists
    U A Hager
    Department of Physiology and Pathophysiology, Friedrich Alexander University Erlangen Nuremberg, Universitaetsstrasse 17, D 91054 Erlangen, Germany
    Neuroscience 151:242-54. 2008
    A recently described family of "orphan" receptors, called Mas-related G-protein-coupled receptors (Mrg), is preferentially expressed in small nociceptive neurons of the rodent and human dorsal root ganglia (DRG)...
  52. doi Chemokine expression in the white matter spinal cord precursor niche after force-defined spinal cord contusion injuries in adult rats
    Friederike Knerlich-Lukoschus
    Department of Neurosurgery, University of Schleswig Holstein Medical Center, Kiel D43 TW001035, Germany
    Glia 58:916-31. 2010
    ..were confirmed by double labeling with markers for major cell types and NSPCs (nestin, Musashi-1, NG2, 3CB2, BLBP). Mitotic profiles were investigated in parallel by BrdU labeling...
  53. doi Heterogeneity in progenitor cell subtypes in the ventricular zone of the zebrafish adult telencephalon
    Martin März
    Institute for Toxicology and Genetics, Forschungszentrum Karlsruhe in the Helmholtz Association, Karlsruhe Institute of Technology, Postfach 3640, 76021 Karlsruhe, Germany
    Glia 58:870-88. 2010
    ..studied the expression of various transgenic or immunocytochemical markers for glial cells (gfap:gfp, cyp19a1b:gfp, BLBP, and S100beta), progenitors (nestin:gfp and Sox2), and neuroblasts (PSA-NCAM) in cycling progenitors of the adult ..
  54. doi Cxcr4 and Cxcl12 expression in radial glial cells of the brain of adult zebrafish
    Nicolas Diotel
    UMR CNRS, IFR, Universite de Rennes, France
    J Comp Neurol 518:4855-76. 2010
    ..where it is co-expressed with established radial glial cell markers, such as brain lipid-binding protein (Blbp) or the estrogen-synthesizing enzyme aromatase B (Cyp19a1b)...
  55. ncbi Interaction of a paraneoplastic cerebellar degeneration-associated neuronal protein with the nuclear helix-loop-helix leucine zipper protein MRG X
    Koichiro Sakai
    The Department of Neurology, Kanazawa Medical University, Kahoku gun, Ishikawa, Japan
    Mol Cell Neurosci 19:477-84. 2002
    ..and co-immunoprecipitation assay that PCD17 interacts with a nuclear helix-loop-helix leucine zipper protein, MRG X...
  56. ncbi Acquisition of neuronal and glial markers by neural crest-derived cells in the mouse intestine
    Heather M Young
    Department of Anatomy and Cell Biology, University of Melbourne, 3010, Victoria, Australia
    J Comp Neurol 456:1-11. 2003
    ..5(+) nor S100b(+). Because some classes of neurons are not present in significant numbers until after birth, the expression of PGP9.5 by developing enteric neurons appeared to precede the expression of neuron type-specific markers...
  57. ncbi MrgD activation inhibits KCNQ/M-currents and contributes to enhanced neuronal excitability
    Robert A Crozier
    Wyeth Research, Discovery Neuroscience, CN 8000, Princeton, New Jersey 08543 8000, USA
    J Neurosci 27:4492-6. 2007
    The recently identified Mas-related gene (Mrg) family of G-protein-coupled receptors is expressed almost exclusively in dorsal root ganglion (DRG) neurons...
  58. doi Neurofibromatosis-1 regulates neuronal and glial cell differentiation from neuroglial progenitors in vivo by both cAMP- and Ras-dependent mechanisms
    Balazs Hegedus
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Cell Stem Cell 1:443-57. 2007
    ..Using a newly developed brain lipid binding protein (BLBP)-Cre mouse strain to study the role of neurofibromin in neural progenitor cell function in the ..
  59. doi Dopamine neuron precursors within the developing human mesencephalon show radial glial characteristics
    Josephine B Hebsgaard
    Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Lund, Sweden
    Glia 57:1648-58. 2009
    ..developing human ventral mesencephalon have a radial morphology and express the radial glial markers Vimentin and BLBP. These radial glia are mitotic and act as precursors for the dopaminergic neurons...
  60. pmc Arachidonic acid drives postnatal neurogenesis and elicits a beneficial effect on prepulse inhibition, a biological trait of psychiatric illnesses
    Motoko Maekawa
    Department of Developmental Neurobiology, Tohoku University Graduate School of Medicine, Sendai, Japan
    PLoS ONE 4:e5085. 2009
    ..In a previous study, we identified Fabp7, a fatty acid binding protein 7 as one of the genes controlling PPI in mice and showed that this gene was ..
  61. ncbi Heterologous expression and characterisation of mouse brain fatty acid binding protein
    F Schnutgen
    Institut fur Biochemie, Westfalische Wilhelms Universitat Munster, Germany
    Biol Chem Hoppe Seyler 377:211-5. 1996
    ..By Western blotting using affinity purified rabbit antibodies raised against the recombinant B-FABP it was demonstrated that in adult mice, B-FABP is predominantly expressed in the olfactory bulb...
  62. ncbi Notch1 signaling regulates radial glia differentiation through multiple transcriptional mechanisms
    Brooke A Patten
    Division of Neuroscience, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 26:3102-8. 2006
    ..differentiation of radial glia through the transcriptional activation of at least two genes, brain lipid binding protein (BLBP) and the erbB2 receptor tyrosine kinase...
  63. pmc The MRG domain of human MRG15 uses a shallow hydrophobic pocket to interact with the N-terminal region of PAM14
    Peng Zhang
    State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Protein Sci 15:2423-34. 2006
    ..in a variety of human tissues, and its orthologs have been found in many other eukaryotes which constitute the MRG protein family...
  64. ncbi Pathogen specific carbohydrate antigen microarrays: a chip for detection of Salmonella O-antigen specific antibodies
    Ola Blixt
    Department of Molecular Biology, Glycan Array Synthesis Core D, Consortium for Functional Glycomics The Scripps Research Institute, CB 248A 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Glycoconj J 25:27-36. 2008
    ..With the larger antigens, containing the backbone sequence Manalpha1-2Rhaalpha1-2Gal (MRG), common backbone-specific antibodies (O-antigen 12) were also detected...
  65. ncbi Isolation and characterization of a neural progenitor cell line from tilapia brain
    Chiu Ming Wen
    Department of Life Sciences, National University of Kaohsiung, Kaohsiung, Taiwan, ROC
    Comp Biochem Physiol A Mol Integr Physiol 149:167-80. 2008
    ..weakly expressed glutamine synthetase (GS), S100 protein, and the neural stem cell markers Sox2 and brain lipid binding protein (BLBP)...
  66. doi Transcriptional changes in insulin- and lipid metabolism-related genes in the hippocampus of olfactory bulbectomized mice
    Peter Gass
    RG Behavioral Biology, University of Heidelberg, Mannheim, Germany
    J Neurosci Res 86:3184-93. 2008
    ..It turned out that the key target -- FABP7 -- fell into the group of transcripts not significantly regulated within the chip data, and another key target -- ..
  67. doi Classification of FABP isoforms and tissues based on quantitative evaluation of transcript levels of these isoforms in various rat tissues
    Takenori Yamamoto
    Institute for Genome Research, University of Tokushima, Kuramotocho 3, Tokushima, 770 8503, Japan
    Biotechnol Lett 31:1695-701. 2009
    ..The 10 FABP isoforms were classified into three categories: (1) isoforms FABP7 and 12 were not markedly expressed in any tissue examined; (2) isoforms showing certain transcript levels in ..
  68. pmc Age-dependent changes in the proteome following complete spinal cord transection in a postnatal South American opossum (Monodelphis domestica)
    Natassya M Noor
    Department of Pharmacology, The University of Melbourne, Parkville, Victoria, Australia
    PLoS ONE 6:e27465. 2011
    ..14-3-3 gamma, cofilin, alpha enolase, heart fatty acid binding protein (FABP3), brain fatty acid binding protein (FABP7) and ubiquitin demonstrated age-related differential expression and were analysed by qRT-PCR...
  69. doi Regional difference of reactive astrogliosis following traumatic brain injury revealed by hGFAP-GFP transgenic mice
    Woon Ryoung Kim
    Department of Anatomy, BK21 Program, Korea University College of Medicine, 126 1 Anam Dong, Sungbuk Gu, Seoul 136 705, Republic of Korea
    Neurosci Lett 513:155-9. 2012
    ..Accordingly, they expressed the progenitor or radial glial markers, such as vimentin, brain lipid binding protein (BLBP) and the green fluorescent protein (GFP) under the control of the human GFAP (hGFAP) promoter...
  70. doi IGF-II promotes stemness of neural restricted precursors
    Amber N Ziegler
    Department of Neurology and Neuroscience, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey, USA
    Stem Cells 30:1265-76. 2012
    ..Q-PCR revealed that IGF-II increased Oct4, Sox1, and FABP7 mRNA levels in NSPs...
  71. pmc Regulation and 3 dimensional culture of tertiary follicle growth
    Yong Pil Cheon
    Division of Developmental Biology and Physiology, School of Biosciences and Chemistry, Sungshin Women s University, Seoul, Korea
    Clin Exp Reprod Med 39:95-106. 2012
    ..For example, a few web pages (http://www.ncbi.nlm.nih.gov; http://mrg.genetics.washington...
  72. pmc MrgC agonism at central terminals of primary sensory neurons inhibits neuropathic pain
    Shao Qiu He
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA
    Pain 155:534-44. 2014
    ..Intrathecal JHU58-induced pain inhibition was dose dependent in SNL rats. Importantly, drug efficacy was lost in Mrg-cluster gene knockout (Mrg KO) mice and was blocked by gene silencing with intrathecal MrgC siRNA and by a ..
  73. doi Overexpression of FABP7 promotes cell growth and predicts poor prognosis of clear cell renal cell carcinoma
    Jiancheng Zhou
    Department of Urology, First Affiliated Hospital of Medical School, Xi an Jiaotong University, Xi an, China
    Urol Oncol 33:113.e9-17. 2015
    ..The aim of the present study was to determine the differential expression of genes between normal kidney and clear cell RCC (ccRCC) samples and investigate the biological function of the most frequently altered gene in RCC cells...
  74. pmc Human endogenous retrovirus group E and its involvement in diseases
    Christelle Le Dantec
    Inserm ESPRI, ERI29 EA2216, SFR ScInBioS, LabEx IGO Immunotherapy Graft Oncology, Réseau épigénétique et réseau canaux ioniques du Cancéropole Grand Ouest, European University of Brittany, Brest 29609, France
    Viruses 7:1238-57. 2015
    ..Finally, better understanding of HERV-E elements may have clinical applications for prevention, diagnosis, prognosis, and therapy...
  75. doi Note: Vibration suppression using tunable vibration absorber based on stiffness variable magneto-rheological gel
    Beom Cheol Shin
    Department of Mechanical and Control Engineering, Handong Global University, Pohang 791 708, South Korea
    Rev Sci Instrum 86:106106. 2015
    ..proposes a novel adaptive tunable vibration absorber (TVA) based on a smart material the magnetorheological gel (MRG) to achieve a wide range of tonal vibration suppression on the primary system to protect any connected sensitive ..
  76. doi Mas-related gene (Mrg) C receptors inhibit mechanical allodynia and spinal microglia activation in the early phase of neuropathic pain in rats
    Dongmei Wang
    College of Life Sciences and Provincial Key Laboratory of Developmental Biology and Neuroscience, Fujian Normal University Fuzhou, Fujian 350108, People s Republic of China
    Neurosci Lett 618:115-21. 2016
    Mas-related gene (Mrg) C receptors are exclusively expressed in the trigeminal and dorsal root ganglia (DRG). However, their functional roles are poorly understood...
  77. pmc Mas-Related Gene (Mrg) C Activation Attenuates Bone Cancer Pain via Modulating Gi and NR2B
    Yu E Sun
    Department of Anaesthesiology, The Affiliated Drum Tower Hospital of Medical College of Nanjing University, Nanjing 210008, Jiangsu, China
    PLoS ONE 11:e0154851. 2016
    This study is to investigate the role of Mas-related gene (Mrg) C in the pathogenesis and treatment of bone cancer pain (BCP).
  78. pmc Structural studies on MRG701 chromodomain reveal a novel dimerization interface of MRG proteins in green plants
    Yanchao Liu
    State Key Laboratory of Molecular Biology, National Center for Protein Science Shanghai, Shanghai Science Research Center, Shanghai Key Laboratory of Molecular Andrology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China
    Protein Cell 7:792-803. 2016
    b>MRG proteins are conserved during evolution in fungi, flies, mammals and plants, and they can exhibit diversified functions. The animal MRGs were found to form various complexes to activate gene expression...
  79. doi Immunocytochemical characterisation of neural stem-progenitor cells from green terror cichlid Aequidens rivulatus
    C M Wen
    Department of Life Sciences, National University of Kaohsiung, Kaohsiung, 81148, Taiwan
    J Fish Biol 90:201-221. 2017
    ..The results confirmed that NSPCs obtained from A. rivulatus brains can proliferate and differentiate into neurons in vitro. Clonal culture can be useful for further studying the distinct NSPCs...
  80. ncbi The genomic organization, promoter position and expression profile of the mouse MRG15 gene
    Kaoru Tominaga
    Department of Cellular and Structural Biology, Sam and Ann Barshop Center for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, STCBM, 15355 Lambda Drive, San Antonio, TX 78245 3207, USA
    Gene 294:215-24. 2002
    MORF4 (mortality factor on chromosome 4) and the novel related MRG (MORF4-related gene) gene family were identified when MORF4 was shown to induce senescence in a subset of tumor cell lines...
  81. ncbi Effect of 2% plain and fluoridated milk on root surface caries in vitro
    Romana Ivancakova
    Department of Dentistry, University Hospital and Medical Faculty of Charles University, 500 05 Hradec Kralove, Czech Republic
    Spec Care Dentist 25:118-23. 2005
    ..surface lesions were created, sectioned and analyzed using polarized light microscopy (PLM) and microradiography (MRG). The sections were covered except for the original surface and assigned to a treatment group...
  82. ncbi Microarray analysis of the genes induced by tetracycline-regulated expression of NDRF/NeuroD2 in P19 cells
    Hisanobu Oda
    Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto 862 0976, Japan
    Biochem Biophys Res Commun 335:458-68. 2005
    ..RNA hybridization analysis confirmed that brain-lipid-binding protein (BLBP) and inhibitor of differentiation 1 (Id1) genes were among the five genes that were rapidly and significantly up-..
  83. ncbi Morphology of enamel in primary teeth from children in Thailand exposed to environmental lead
    Nattaporn Youravong
    Epidemiology Unit, Faculty of Medicine, Prince of Songkla University, Thailand
    Sci Total Environ 348:73-81. 2005
    ..The morphology of the enamel was examined by polarized light microscopy (PLM), microradiography (MRG), and scanning electron microscopy (SEM)...
  84. ncbi Non-lethal active caspase-3 expression in Bergmann glia of postnatal rat cerebellum
    Sowmini Oomman
    Department of Physiology, Texas Tech University Health Sciences Center, Room 5A163, Lubbock, TX 79430, USA
    Brain Res Dev Brain Res 160:130-45. 2005
    ..Thus, this study supports the hypothesis that active caspase-3 may be regulating both differentiation of Bergmann glia by allowing the cells to exit the cell cycle and their morphogenesis...
  85. pmc Origin, maturation, and astroglial transformation of secondary radial glial cells in the developing dentate gyrus
    Bianka Brunne
    Center of Neurosciences, University of Freiburg, Freiburg, Germany
    Glia 58:1553-69. 2010
    ..Time-lapse imaging of acute hippocampal slices from hGFAP-eGFP transgenic mice provides direct evidence for such a migration mode of differentiating astroglial cells in the developing dentate gyrus...
  86. doi Use of existing water, sediment, and tissue data to screen ecological risks to the endangered Rio Grande silvery minnow
    Michael D Marcus
    Tetra Tech, Inc 6121 Indian School Road NE, Suite 205, Albuquerque, NM 87110, United States
    Sci Total Environ 409:83-94. 2010
    ..risk assessment was applied to two extensive, but previously unanalyzed datasets from the middle Rio Grande (MRG) in New Mexico...
  87. pmc Fatty-acid binding proteins modulate sleep and enhance long-term memory consolidation in Drosophila
    Jason R Gerstner
    Department of Genetics, University of Wisconsin Madison, Madison, Wisconsin, United States of America
    PLoS ONE 6:e15890. 2011
    ..Here we test the effect of overexpressing the brain-type fatty acid binding protein (Fabp7) on sleep and long-term memory (LTM) formation in Drosophila melanogaster...
  88. doi MRG-binding protein contributes to colorectal cancer development
    Kiyoshi Yamaguchi
    Division of Clinical Genome Research, Advanced Clinical Research Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Cancer Sci 102:1486-92. 2011
    ..Our findings might be helpful for the identification of a specific biomarker for colorectal cancer and the development of diagnostic and/or therapeutic approaches...
  89. pmc Cell proliferation and cytoarchitectural remodeling during spinal cord reconnection in the fresh-water turtle Trachemys dorbignyi
    María Inés Rehermann
    Departamento de Neurofisiología Celular y Molecular, Avenida Italia 3318, Montevideo, Uruguay
    Cell Tissue Res 344:415-33. 2011
    ..Most dividing cells expressed the brain lipid-binding protein (BLBP). Cells with BrdU-positive nuclei expressed glial fibrillary acidic protein...
  90. doi Generation and identification of rat fetal cerebral radial glia-like cells in vitro
    Haoming Li
    Department of Anatomy and Neurobiology, The Jiangsu Key Laboratory of Neuroregeneration, Nantong University, No 19 Qixiu Road, Nantong, China
    In Vitro Cell Dev Biol Anim 47:431-7. 2011
    ..Taken together, we acquired and identified some properties of rat-derived RG-like cells from fetal cerebral cortices in vitro...
  91. doi Gene expression profiling reveals potential key pathways involved in pyrazinamide-mediated hepatotoxicity in Wistar rats
    Yun Zhang
    Jiangsu Center of Drug Screening, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing, 210009, China
    J Appl Toxicol 33:807-19. 2013
    ..reaction confirmed the regulation of selected genes involved in PZA-hepatotoxicity (Ephx1, Cyp2b1, Gstm1, Gstp1, Fabp7, Acaa1, Cpt-1b, Cyp8b1, Hmox1 and Ntrk1)...
  92. pmc Reverse engineering a mouse embryonic stem cell-specific transcriptional network reveals a new modulator of neuronal differentiation
    Rossella De Cegli
    Telethon Institute of Genetics and Medicine, Via P Castellino 111, Napoli 80131, Italy
    Nucleic Acids Res 41:711-26. 2013
    ..marker Vglut2 and a strong down-regulation of the GABAergic neurons marker GAD65 and of the radial glia marker Blbp. We confirmed E13 expression in the cerebral cortex of adult mice and during development...
  93. pmc Histone deacetylase 2 (HDAC2) protein-dependent deacetylation of mortality factor 4-like 1 (MORF4L1) protein enhances its homodimerization
    Yan Chen
    From the Department of Medicine, Acute Lung Injury Center of Excellence, and
    J Biol Chem 289:7092-8. 2014
    ..Among a stretch of ∼10 amino acids in the NH2 terminus between the chromodomain and MORF4-related gene (MRG) domain within MORF4L1, Lys-148 is normally acetylated...
  94. doi Glial modulation of vibrissal sensory processing in rats
    Man Li Sun
    Department of Physiology, Key Laboratory of Medical Neurobiology of Ministry of Health, Zhejiang Province Key Laboratory of Neurobiology, Zhejiang University School of Medicine, Hangzhou 310058, Zhejiang, People s Republic of China
    Chin J Physiol 56:309-17. 2013
    ..Immunohistochemical staining of brain lipid binding protein (BLBP) and NeuN showed AA decreased cell number of astrocytes but not neurons in the barrel cortex...
  95. doi Metal accumulation and differentially expressed proteins in gill of oyster (Crassostrea hongkongensis) exposed to long-term heavy metal-contaminated estuary
    Lianzhong Luo
    Department of Pharmacy, Xiamen Medical College, Xiamen 361008, PR China State Key Laboratory of Marine Environmental Science, Xiamen University, Xiamen 361005, PR China
    Fish Shellfish Immunol 38:318-29. 2014
    ..binding toxic metals with metallothionein-like proteins (MTLP) and storing toxic metals in metal-rich granules (MRG) with insoluble forms were the important strategies of oyster to detoxify the toxic metals and adapt to the high ..
  96. pmc Differential expressions of BMPR1α, ACTN4α and FABP7 in Hirschsprung disease
    WeiLin Wang
    Key Laboratory of Health Ministry for Congenital Malformations, Shengjing Hospital of China Medical University 36 Sanhao Street Heping District, Shenyang, Liaoning, 110004, The People s Republic of China
    Int J Clin Exp Pathol 7:2312-8. 2014
    ..bone morphogenetic protein receptor-type IA (BMPR1α), actinin-alpha 4 (ACTN4α) and fatty acid binding protein 7 (FABP7) play important roles in the differentiation and development of neurons...
  97. pmc Peptidomimetics of Arg-Phe-NH2 as small molecule agonists of Mas-related gene C (MrgC) receptors
    Niyada Hin
    Brain Science Institute, Johns Hopkins University, Baltimore, MD 21205, United States
    Bioorg Med Chem 22:5831-7. 2014
    ..These new peptidomimetics should complement the existing small molecule human MrgX1 agonists and enhance our ability to assess the therapeutic utility of targeting Mrg receptors in rodent models.
  98. doi Pluripotent stem cell-derived radial glia-like cells as stable intermediate for efficient generation of human oligodendrocytes
    Raphaela Gorris
    Institute of Reconstructive Neurobiology, Life and Brain Center, University of Bonn, Germany
    Glia 63:2152-67. 2015
    ..RGL-NPCs) expressing typical neural stem cell markers such as nestin, ASCL1, SOX2, and PAX6 as well as RG markers BLBP, GLAST, vimentin, and GFAP...
  99. pmc SSEA-4 and YKL-40 positive progenitor subtypes in the subventricular zone of developing human neocortex
    Christian B Brøchner
    Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, Copenhagen, DK 2200, Denmark
    Glia 64:90-104. 2016
    ..A few small rounded SSEA-4 and YKL-40 labeled cells were present in the radial glial BLBP positive proliferative zones adjacent to the lateral ganglionic eminence from 12th week post conception...
  100. doi Icariin Metabolism by Human Intestinal Microflora
    Hailong Wu
    Metalloenzyme Research Group and Department of Integrative Plant Science, Chung Ang University, Anseong 17546, Korea
    Molecules 21:. 2016
    ..Together with human intestinal microflora, the three bacteria Streptococcus sp. MRG-ICA-B, Enterococcus sp. MRG-ICA-E, and Blautia sp...
  101. doi Age-dependent acute interference with stem and progenitor cell proliferation in the hippocampus after exposure to 1800 MHz electromagnetic radiation
    Falin Xu
    a Department of Neonatology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, P R China
    Electromagn Biol Med 36:158-166. 2017
    ..with BrdU and by immunohistochemical staining for phosphor-histone H3 (PHH3) and brain lipid-binding protein (BLBP)...

Research Grants27

  1. Transcription factors regulating sensory gene expression and pain pathways
    Eric E Turner; Fiscal Year: 2011
    ..mice, with an emphasis on genes mediating pain pathways, including sensory neuropeptides and members of the Trp, Mrg and NaV gene families...
  2. Dale G Deutsch; Fiscal Year: 2016
    ..will then be tested employing a fluorescent displacement assay for their ability to bind mainly to FABP5 and FABP7 that occur in the nervous system...
  3. Anandamide Carrier Proteins as Drug Targets
    Jason Jianxin Guo; Fiscal Year: 2013
    ..the structural and binding characteristics of two lipid carrier proteins, human brain fatty acid bindin protein (FABP7) and epidermal FABP (FABP5), to a range of selected ligands including the endocannabinoids and several widely used ..
  4. Role of the Mrg family of GPCRs in nociception
    David Anderson; Fiscal Year: 2009
    ..state-of-the art methods of mouse molecular genetics to generate and analyze strains of mice in which different Mrg genes have been deleted, and in which Mrg-expressing neurons can be inducibly ablated or silenced, or their second- ..
  5. MR-guided focused ultrasound system
    Fergus V Coakley; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The proposal seeks funding for an MR-guided Focused UltraSound (MRg-FUS) system (ExAblate(R) 2000, Insightec Inc...
  6. FREQUENCY DOMAIN OPTICAL IMAGING OF BREAST CANCER
    Keith D Paulsen; Fiscal Year: 2012
    ..These findings have motivated our proposal to continue to pursue MR-guided (MRg) NIR optical breast tomography because of the convincing evidence we have generated to date that MR guidance ..
  7. Regulation of Hepatic Repair Response by Metabolites of the Uric Acid Pathway
    Wajahat Zafar Mehal; Fiscal Year: 2013
    ..We have demonstrated that nucleic acids via TLR9, adenosine via the A2a receptor, and adenine via the Mrg receptor are required for normal FG in the liver...
  8. A screen for small molecule modulators of human GPCR MrgX1
    Xinzhong Dong; Fiscal Year: 2012
    ..Therefore, modulating Mrg activation offers a unique and promising target to treat chronic pain and itch...
  9. MAST CELL NERVE INTERACTIONS IN AIRWAYS
    Bradley J Undem; Fiscal Year: 2010
    ..In Aim 2 we address our novel hypothesis that mast cell release mediators capable of stimulated mas-related-gene (Mrg) receptors on sensory nerves resulting in an increase in C-fiber excitability...
  10. Riparian nutrients and food webs on a regulated river
    TERESA TIBBETS; Fiscal Year: 2005
    ..The middle Rio Grande river (MRG), which flows through central New Mexico, contains one of the most extensive riparian forests of native cottonwood ..
  11. INTERACTION OF OMEGA 3 FATTY ACIDS AND NOVEL FATTY ACID
    Y Shi; Fiscal Year: 2001
    ..and a fatty acid binding protein (FABP) has recently been identified, characterized, and named as Mammary derived growth inhibitor Related Gene MRG. Being as a new member of FABP family, MRG has a highest binding affinity to DHA...
  12. CONTROL OF NEURAL CELL IDENTITY IN DEVELOPING CNS
    MARY HATTEN; Fiscal Year: 2002
    ..to define the regulation of the zinc finger transcription factor RU49, a granule cell marker, and the brain lipid binding protein BLBP, as well as novel genes that show regulated expression during cerebellar histogenesis...
  13. PROTEIN MODELING BY SATISFACTION OF SPATIAL RESTRAINTS
    Andrej Sali; Fiscal Year: 2000
    ..Comparative modeling will be used to study the role of lipids in the function of the brain lipid binding protein. In another application, the 3D structure of the voltage-activated potassium channel will be modeled, ..
  14. N-3 fatty acid & binding protein MRG on mammary tumor
    YUENIAN SHI; Fiscal Year: 2006
    ..and a fatty acid binding protein (FABP) has recently been identified, characterized, and named Mammary derived growth inhibitor Related Gene (MRG)...
  15. MECHANISMS OF NEURAL PATTERNING IN MAMMALIAN FOREBRAIN
    Gordon Fishell; Fiscal Year: 2007
    ..progenitors exist in the cerebellum throughout embryonic development and that they express the radial glial marker BLBP. We will apply in vitro and in vivo methods to see if like in the forebrain Notch activation bestows stem cell ..
  16. Multiparametric MRI characterization of breast tissue
    Michael Jacobs; Fiscal Year: 2009
    ..abstract_text> ..
  17. OspA and autoimmunity in chronic Lyme disease
    Armin Alaedini; Fiscal Year: 2007
    ..Identification of specific immune reactivity to an autoantigen might also be useful as a diagnostic marker and for monitoring of disease activity in affected patients. [unreadable] [unreadable] [unreadable]..
  18. Immune reactivity to synapsin in the neuropathy and ataxia of celiac disease
    Armin Alaedini; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  19. Connections and function of reproductive neural circuits
    TODD ANTHONY; Fiscal Year: 2008
    ..abstract_text> ..
  20. Post-natal neurogenesis in the turtle spinal cord
    RAUL RUSSO; Fiscal Year: 2009
    ..This knowledge is essential to understand basic neurogenic mechanisms that may remain "dormant" in the mammalian spinal cord but could hopefully be "awakened" to alleviate spinal cord diseases. ..
  21. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin L Hughes; Fiscal Year: 2010
    ..In addition, by increasing our understanding of the population diversity and evolutionary history of human immune system genes, this research will enhance our knowledge of human immune function in health and disease. ..
  22. Genetic analysis of cone photoreceptor determination
    PAMELA RAYMOND; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  23. NEW NEURONS IN THE RETINA
    Pamela A Raymond; Fiscal Year: 2010
    ..abstract_text> ..
  24. 2006 Visual System Development Gordon Conference
    PAMELA RAYMOND; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  25. Nutrition and Cancer: Statewide Preceptor Education
    JUDITH ASHLEY; Fiscal Year: 2006
    ..abstract_text> ..
  26. Gene Duplication and Genome Evolution
    Austin Hughes; Fiscal Year: 2004
    ..5) Examining the role of transposable elements in duplication of genomic segments by testing for nonrandom association between these elements and putatively duplicated blocks in the yeast genome. ..
  27. Analysis of MRG family and hTERT null phenotypes by RNAi
    Michael Bertram; Fiscal Year: 2002
    ..In addition, highly conserved MORF4 Related Genes (MRG) have been identified in numerous eukaryotes including two additional expressed family members in humans and one in ..