FABP6

Summary

Gene Symbol: FABP6
Description: fatty acid binding protein 6
Alias: I-15P, I-BABP, I-BALB, I-BAP, ILBP, ILBP3, ILLBP, gastrotropin, fatty acid binding protein 6, ileal, ileal bile acid binding protein, ileal lipid-binding protein, illeal lipid-binding protein, intestinal 15 kDa protein
Species: human
Products:     FABP6

Top Publications

  1. Horváth G, Egyed O, Tang C, Kovacs M, Micsonai A, Kardos J, et al. Ligand entry in human ileal bile acid-binding protein is mediated by histidine protonation. Sci Rep. 2019;9:4825 pubmed publisher
  2. Romagnolo D, Donovan M, Doetschman T, Selmin O. n-6 Linoleic Acid Induces Epigenetics Alterations Associated with Colonic Inflammation and Cancer. Nutrients. 2019;11: pubmed publisher
    ..However, epigenetic activation of Ptsg-2 coupled with silencing of Apc and accumulation of C-JUN and Ccnd1 may increase the risk of inflammation and cancer of the colon. ..
  3. Nagao K, Shinohara N, Smit F, de Weijert M, Jannink S, Owada Y, et al. Fatty acid binding protein 7 may be a marker and therapeutic targets in clear cell renal cell carcinoma. BMC Cancer. 2018;18:1114 pubmed publisher
    ..We found that The Cancer Genome Atlas Research Network (TCGA) database shows FABP6 and 7 as equally overexpressed in the FABP family...
  4. Fang C, Chen M, Chang T, Wu C, Chang J, Huang H, et al. Idi1 and Hmgcs2 Are Affected by Stretch in HL-1 Atrial Myocytes. Int J Mol Sci. 2018;19: pubmed publisher
    ..in stretched monocytes (Idi1, Olr1, Nr1h4, Fabp2, Prkag3, Slc27a5, Fabp6) revealed differential upregulation with an altered fold change >1.5...
  5. Kang Y, Brown D, Kirby J. Brucella neotomae Recapitulates Attributes of Zoonotic Human Disease in a Murine Infection Model. Infect Immun. 2019;87: pubmed publisher
    ..Therefore, the B. neotomae BALB/c infection model offers a promising system to accelerate and complement experimental work in the genus Brucella. ..
  6. Eskandari E, Mahjoubi F, Motalebzadeh J. An integrated study on TFs and miRNAs in colorectal cancer metastasis and evaluation of three co-regulated candidate genes as prognostic markers. Gene. 2018;679:150-159 pubmed publisher
    ..GRN was analyzed structurally and then, two DETFs (LEF1 and ETV4) and a less-well known DEG (FABP6) by real time qRT-PCR in 50 patients with colorectal cancer were quantified...
  7. Favretto F, Ceccon A, Zanzoni S, D Onofrio M, Ragona L, Molinari H, et al. The unique ligand binding features of subfamily-II iLBPs with respect to bile salts and related drugs. Prostaglandins Leukot Essent Fatty Acids. 2015;95:1-10 pubmed publisher
    ..This review collects the major findings related to bile salt interactions with iLBPs aiming to provide keys for a deeper understanding of protein-mediated intracellular bile salt trafficking. ..
  8. Nossoni Z, Assar Z, Yapici I, Nosrati M, Wang W, Berbasova T, et al. Structures of holo wild-type human cellular retinol-binding protein II (hCRBPII) bound to retinol and retinal. Acta Crystallogr D Biol Crystallogr. 2014;70:3226-32 pubmed publisher
    Cellular retinol-binding proteins (CRBPs) I and II, which are members of the intracellular lipid-binding protein (iLBP) family, are retinoid chaperones that are responsible for the intracellular transport and delivery of both retinol and ..
  9. Cos P, Janssens J, Piñón A, Cuesta Rubio O, Yglesias Rivera A, Díaz García A, et al. Efficacy of Four Solanum spp. Extracts in an Animal Model of Cutaneous Leishmaniasis. Medicines (Basel). 2018;5: pubmed publisher
    ..05) were observed for IL-12. Conclusions:In vivo effects of Solanum extracts were demonstrated, suggesting that this genus could be further explored as a new antileishmanial alternative. ..

More Information

Publications75

  1. Andersson K, Chawade A, Thuresson N, Rascon A, Oste R, Sterner O, et al. Wholegrain oat diet changes the expression of genes associated with intestinal bile acid transport. Mol Nutr Food Res. 2017;61: pubmed publisher
    ..The apical sodium-dependent bile acid transporter (ASBT, Slc10a) and the intracellular bile acid binding protein (Fabp6) were both upregulated, whereas small heterodimer partner-1 (Shp-1) and apolipoprotein CII (Apoc2) were ..
  2. Deng Y, Huang X, Su M, Yu P, Zhang Z, Liu Q, et al. Hypolipidemic effect of SIPI-7623, a derivative of an extract from oriental wormwood, through farnesoid X receptor antagonism. Chin J Nat Med. 2018;16:572-579 pubmed publisher
    ..In conclusion, SIPI-7623 could be a promising lead compound for development of drugs to treat hyperlipidemia and atherosclerosis. ..
  3. Stafuzza N, Borges M, Amaral Trusty M. Sequence characterization and comparative analysis of the gastrotropin gene in buffalo (Bubalus bubalis). Genet Mol Res. 2014;13:10934-42 pubmed publisher
    In this study, we compared the complete sequence of the FABP6 gene from an animal representing the Murrah breed of the river buffalo (Bubalus bubalis) with the gene sequence from different mammals...
  4. Yadav V, Hussain A, Sahoo K, Awasthi V. Remediation of hemorrhagic shock-induced intestinal barrier dysfunction by treatment with diphenyldihaloketones EF24 and CLEFMA. J Pharmacol Exp Ther. 2014;351:413-22 pubmed publisher
    ..occludens, claudin, and occludin) and epithelial injury markers [myeloperoxidase, ileal lipid-binding protein (ILBP), CD163, and plasma citrulline]...
  5. Orito W, Ohhira F, Ogasawara M. Gene expression profiles of FABP genes in protochordates, Ciona intestinalis and Branchiostoma belcheri. Cell Tissue Res. 2015;362:331-45 pubmed publisher
    ..together with a member of the cellular retinol-binding proteins (CRBPs), the intracellular-lipid-binding protein (iLBP) family. In vertebrates, several types of FABP have been isolated and classified into three subfamilies: 2-4...
  6. Qin G, Lian J, Huang L, Zhao Q, Liu S, Zhang Z, et al. Metformin blocks myeloid-derived suppressor cell accumulation through AMPK-DACH1-CXCL1 axis. Oncoimmunology. 2018;7:e1442167 pubmed publisher
    ..b>Conclusions: A novel anti-tumor effect of metformin, which is mediated by reducing PMN-MDSC accumulation in the tumor microenvironment via AMPK/DACH1/CXCL1 axis. ..
  7. Levenson E, Martens C, Kanakabandi K, Turner C, Virtaneva K, Paneru M, et al. Comparative Transcriptomic Response of Primary and Immortalized Macrophages to Murine Norovirus Infection. J Immunol. 2018;200:4157-4169 pubmed publisher
    ..Awareness of these differences at the gene level will be important in the application of a given permissive culture system to the study of NoV immunity, pathogenesis, and drug development. ..
  8. Manukumar H, Chandrasekhar B, Rakesh K, Ananda A, Nandhini M, Lalitha P, et al. Novel T-C@AgNPs mediated biocidal mechanism against biofilm associated methicillin-resistant Staphylococcus aureus (Bap-MRSA) 090, cytotoxicity and its molecular docking studies. Medchemcomm. 2017;8:2181-2194 pubmed publisher
    ..These excellent properties of T-C@AgNPs highlight for the first time its pharmacology and potential in medicinal drug development applications for future research. ..
  9. Xiao Li W, Liang L, Hui Z, Xing W, Zhi Yong T, Hui X, et al. [Effect of exogenous nitric oxide on antioxidants from mice infected with Trichinella spiralis]. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi. 2016;29:48-52 pubmed publisher
    ..635, P?< 0.05), ?MDA?????? (r?MDA= 0.697, r?MDA = 0.764, P?< 0.05)? ?? ????? ?????????????????????, SOD?CAT?GSH-Px????; ???NO??????????SOD? CAT?GSH-Px??, ???????????. ..
  10. Duggavathi R, Siddappa D, Schuermann Y, Pansera M, Menard I, Praslickova D, et al. The fatty acid binding protein 6 gene (Fabp6) is expressed in murine granulosa cells and is involved in ovulatory response to superstimulation. J Reprod Dev. 2015;61:237-40 pubmed publisher
    The fatty acid binding protein 6 (Fabp6) is commonly regarded as a bile acid binding protein found in the distal portion of the small intestine and has been shown to be important in maintaining bile acid homeostasis...
  11. Bayır M, Bayır A, Wright J. Divergent spatial regulation of duplicated fatty acid-binding protein (fabp) genes in rainbow trout (Oncorhynchus mykiss). Comp Biochem Physiol Part D Genomics Proteomics. 2015;14:26-32 pubmed publisher
    ..2) most likely were generated by the salmonid-specific WGD subsequent to the teleost-specific WGD; and fabp3 and fabp6 exist as single copy genes in the rainbow trout genome...
  12. Hirobe Jahn S, Harsch S, Renner O, Richter D, Müller O, Stange E. Association of FXR gene variants with cholelithiasis. Clin Res Hepatol Gastroenterol. 2015;39:68-79 pubmed publisher
    ..differences between lean rs11110385 carriers and non-carriers were observed in FXR target genes (decrease: ILBP: P=0.042, OSTalpha: P=0.071, FGF19: P=0.011. Increase: LRH1: P=0.044)...
  13. Reisinger K, Poeze M, Hulsewé K, van Acker B, van Bijnen A, Hoofwijk A, et al. Accurate prediction of anastomotic leakage after colorectal surgery using plasma markers for intestinal damage and inflammation. J Am Coll Surg. 2014;219:744-51 pubmed publisher
    ..damage markers, intestinal fatty acid binding protein; liver fatty acid binding protein; and ileal bile acid binding protein, were measured...
  14. Al Fayi M, Gou X, Forootan S, Al Jameel W, Bao Z, Rudland P, et al. The increased expression of fatty acid-binding protein 9 in prostate cancer and its prognostic significance. Oncotarget. 2016;7:82783-82797 pubmed publisher
    ..mRNA levels of 10 FABPs in benign and malignant prostate cell lines and identified the differentially expressed FABP6 and FABP9 mRNAs whose levels in all malignant cell lines were higher than those in the benign cells...
  15. Chen W, Dong J, Plate L, Mortenson D, Brighty G, Li S, et al. Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue. J Am Chem Soc. 2016;138:7353-64 pubmed publisher
    ..hydrophobic arylfluorosulfates selectively react with a few members of the intracellular lipid binding protein (iLBP) family. A central function of iLBPs is to deliver small-molecule ligands to nuclear hormone receptors...
  16. Uribe J, Collado Romero M, Zaldívar López S, Arce C, Bautista R, Carvajal A, et al. Transcriptional analysis of porcine intestinal mucosa infected with Salmonella Typhimurium revealed a massive inflammatory response and disruption of bile acid absorption in ileum. Vet Res. 2016;47:11 pubmed publisher
    ..Infection also down-regulated genes of the FXR pathway (e.g., NR1H4, FABP6, APOA1, SLC10A2), indicating disruption of the bile acid absorption in ileum...
  17. Ceccon A, Busato M, Pérez Santero S, D Onofrio M, Musiani F, Giorgetti A, et al. Transient Interactions of a Cytosolic Protein with Macromolecular and Vesicular Cosolutes: Unspecific and Specific Effects. Chembiochem. 2015;16:2633-45 pubmed publisher
    ..We investigated the associations between a test cytosolic protein, human ileal bile acid binding protein (IBABP), and model cosolutes mimicking macromolecular and lipid membrane intracellular components...
  18. Notcovich S, DeNicolo G, Flint S, Williamson N, Gedye K, Grinberg A, et al. Biofilm-Forming Potential of Staphylococcus aureus Isolated from Clinical Mastitis Cases in New Zealand. Vet Sci. 2018;5: pubmed publisher
    ..Results show that most of the S. aureus isolates, though not possessing one of the biofilm-forming genes, were able to produce biofilms. MTA was more frequently positive in identifying biofilm-forming isolates than CRA. ..
  19. Selwyn F, Csanaky I, Zhang Y, Klaassen C. Importance of Large Intestine in Regulating Bile Acids and Glucagon-Like Peptide-1 in Germ-Free Mice. Drug Metab Dispos. 2015;43:1544-56 pubmed publisher
  20. McClung J, McCord T, Ryan T, Schmidt C, Green T, Southerland K, et al. BAG3 (Bcl-2-Associated Athanogene-3) Coding Variant in Mice Determines Susceptibility to Ischemic Limb Muscle Myopathy by Directing Autophagy. Circulation. 2017;136:281-296 pubmed publisher
    ..These results highlight a pathway that preserves tissue survival and muscle function in the setting of ischemia. ..
  21. Johnston I, Nolan J, Pattni S, Appleby R, Zhang J, Kennie S, et al. Characterizing Factors Associated With Differences in FGF19 Blood Levels and Synthesis in Patients With Primary Bile Acid Diarrhea. Am J Gastroenterol. 2016;111:423-32 pubmed publisher
    ..50, P=0.02) and ileal bile acid binding protein (IBABP) (median 2.2-fold, rs=0.47, P=0.04)...
  22. Xu G, Zhang M, Zhu H, Xu J. A 15-gene signature for prediction of colon cancer recurrence and prognosis based on SVM. Gene. 2017;604:33-40 pubmed publisher
    ..and five gene expression profile data confirmation, a 15-gene signature (HES5, ZNF417, GLRA2, OR8D2, HOXA7, FABP6, MUSK, HTR6, GRIP2, KLRK1, VEGFA, AKAP12, RHEB, NCRNA00152 and PMEPA1) were identified as a predictor of ..
  23. Venkatachalam A, Parmar M, Wright J. Evolution of the duplicated intracellular lipid-binding protein genes of teleost fishes. Mol Genet Genomics. 2017;292:699-727 pubmed publisher
    ..evolution, and transcriptional regulation of the multigene family of intracellular lipid-binding protein (iLBP) genes from teleost fishes...
  24. Schrödter S, Braun M, Syring I, Klümper N, Deng M, Schmidt D, et al. Identification of the dopamine transporter SLC6A3 as a biomarker for patients with renal cell carcinoma. Mol Cancer. 2016;15:10 pubmed publisher
    ..not studied in ccRCC in depth, was confirmed using qPCR (upregulation: SLC6A3, NPTX2, TNFAIP6, NDUFA4L2, ENPP3, FABP6, SPINK13; downregulation: FXYD4, SLC12A1, KNG1, NPHS2, SLC13A3, GCGR, PLG)...
  25. Greis C, Rasuly Z, Jánosi R, Kordelas L, Beelen D, Liebregts T. Intestinal T lymphocyte homing is associated with gastric emptying and epithelial barrier function in critically ill: a prospective observational study. Crit Care. 2017;21:70 pubmed publisher
    ..This is not simply due to differences in overall severity of illness at ICU admission and may represent a pathophysiological mechanism of gut-directed immune activation leading to impaired barrier function in the critically ill. ..
  26. Chow E, Quach H, Zhang Y, Wang J, Evans D, Li A, et al. Disrupted Murine Gut-to-Human Liver Signaling Alters Bile Acid Homeostasis in Humanized Mouse Liver Models. J Pharmacol Exp Ther. 2017;360:174-191 pubmed
    ..induction of intestinal farnesoid X receptor (Fxr) genes: fibroblast growth factor 15 (Fgf15), mouse ileal bile acid binding protein (Ibabp), small heterodimer partner (Shp), and the organic solute transporter alpha (Ost?), were ..
  27. Dermadi D, Valo S, Ollila S, Soliymani R, Sipari N, Pussila M, et al. Western Diet Deregulates Bile Acid Homeostasis, Cell Proliferation, and Tumorigenesis in Colon. Cancer Res. 2017;77:3352-3363 pubmed publisher
    ..Despite increased luminal BA, colonocytes from WD-fed mice exhibited decreased expression of the BA transporters FABP6, OSTβ, and ASBT and decreased concentrations of secondary BA deoxycholic acid and lithocholic acid, indicating ..
  28. May P, Bremond P, Sauzet C, Piccerelle P, Grimaldi F, Champion S, et al. In Vitro Cocktail Effects of PCB-DL (PCB118) and Bulky PCB (PCB153) with BaP on Adipogenesis and on Expression of Genes Involved in the Establishment of a Pro-Inflammatory State. Int J Mol Sci. 2018;19: pubmed publisher
    ..The direct regulatory effect of PCBs on both ADGG and INFG is usually rather lower than that of BaP and synergistic or antagonistic cocktail effects are clearly observed. ..
  29. Derikx J, van Waardenburg D, Thuijls G, Willigers H, Koenraads M, van Bijnen A, et al. New Insight in Loss of Gut Barrier during Major Non-Abdominal Surgery. PLoS ONE. 2008;3:e3954 pubmed publisher
    ..These data shed new light on the potential role of peroperative circulatory perturbation and intestinal barrier loss. ..
  30. Selmin O, Fang C, Lyon A, Doetschman T, Thompson P, Martinez J, et al. Inactivation of Adenomatous Polyposis Coli Reduces Bile Acid/Farnesoid X Receptor Expression through Fxr gene CpG Methylation in Mouse Colon Tumors and Human Colon Cancer Cells. J Nutr. 2016;146:236-42 pubmed publisher
  31. Sousa Batista A, Pacienza Lima W, Arruda Costa N, Falcão C, Ré M, Rossi Bergmann B. Depot Subcutaneous Injection with Chalcone CH8-Loaded Poly(Lactic-Co-Glycolic Acid) Microspheres as a Single-Dose Treatment of Cutaneous Leishmaniasis. Antimicrob Agents Chemother. 2018;62: pubmed publisher
    ..Together, these findings show that CH8/PLGA microparticles can be effectively and safely used for single-dose treatment of CL. ..
  32. Yeh M, Shih Y, Chung H, Chou J, Lu H, Liu C, et al. Chitosan promotes immune responses, ameliorates glutamic oxaloacetic transaminase and glutamic pyruvic transaminase, but enhances lactate dehydrogenase levels in normal mice in vivo. Exp Ther Med. 2016;11:1300-1306 pubmed
    ..In addition, it significantly increased LDH activity, to a level similar to that in normal mice, indicating that chitosan can protect against liver injury. ..
  33. Venkatachalam A, Fontenot Q, Farrara A, Wright J. Fatty acid-binding protein genes of the ancient, air-breathing, ray-finned fish, spotted gar (Lepisosteus oculatus). Comp Biochem Physiol Part D Genomics Proteomics. 2018;25:19-25 pubmed publisher
    ..focused on the fate of duplicated copies of a multigene family coding for the intracellular lipid-binding protein (iLBP) genes in the teleost fishes...
  34. Horváth G, Biczók L, Majer Z, Kovacs M, Micsonai A, Kardos J, et al. Structural insight into a partially unfolded state preceding aggregation in an intracellular lipid-binding protein. FEBS J. 2017;284:3637-3661 pubmed publisher
    ..The response of human I-BABP to temperature elevation is discussed in the context of the folding/unfolding behaviour of different members of the iLBP family.
  35. Oelkers P, Dawson P. Cloning and chromosomal localization of the human ileal lipid-binding protein. Biochim Biophys Acta. 1995;1257:199-202 pubmed
    A human ileal lipid-binding protein (ILBP3) cDNA was isolated and shown to encode a 128 amino acid protein with homology to the fatty acid-binding protein gene family...
  36. Turpin E, Fang H, Thomas N, Hirst J. Cooperativity and site selectivity in the ileal lipid binding protein. Biochemistry. 2013;52:4723-33 pubmed publisher
    The ileal lipid binding protein (ILBP or I-BABP) binds bile salts with positive cooperativity and has unusual site selectivity, whereby cholic acid binds preferentially in one site and chenodeoxycholic in another, despite both sites ..
  37. Fang C, Filipp F, Smith J. Unusual binding of ursodeoxycholic acid to ileal bile acid binding protein: role in activation of FXR?. J Lipid Res. 2012;53:664-73 pubmed publisher
    ..The aim of this study was to determine whether ileal bile acid binding protein (IBABP) has a role in mediating the effects of UDCA...
  38. Fang C, Dean J, Smith J. A novel variant of ileal bile acid binding protein is up-regulated through nuclear factor-kappaB activation in colorectal adenocarcinoma. Cancer Res. 2007;67:9039-46 pubmed
    b>Ileal bile acid binding protein (IBABP) is the only cytosolic protein known to bind and transport bile acids...
  39. Lucke C, Zhang F, Hamilton J, Sacchettini J, Rüterjans H. Solution structure of ileal lipid binding protein in complex with glycocholate. Eur J Biochem. 2000;267:2929-38 pubmed
    b>Ileal lipid binding protein (ILBP) is a cytosolic lipid-binding protein that binds both bile acids and fatty acids...
  40. Xu G, Pan L, Erickson S, Forman B, Shneider B, Ananthanarayanan M, et al. Removal of the bile acid pool upregulates cholesterol 7alpha-hydroxylase by deactivating FXR in rabbits. J Lipid Res. 2002;43:45-50 pubmed
    ..Further, lack of the high affinity ligand supply was associated with downregulation of hepatic FXR mRNA levels...
  41. Cui J, Huang L, Zhao A, Lew J, Yu J, Sahoo S, et al. Guggulsterone is a farnesoid X receptor antagonist in coactivator association assays but acts to enhance transcription of bile salt export pump. J Biol Chem. 2003;278:10214-20 pubmed
  42. Barley N, Taylor V, Shaw Smith C, Chakravarty P, Howard A, Legon S, et al. Human ileal bile acid-binding protein promoter and the effects of CDX2. Biochim Biophys Acta. 2003;1630:138-43 pubmed
    ..Studies with the human IBABP gene (FABP6, on chromosome 5q33.3-q34) defined the major transcription start site and identified conserved elements...
  43. Fisher E, Nitz I, Lindner I, Rubin D, Boeing H, Mohlig M, et al. Candidate gene association study of type 2 diabetes in a nested case-control study of the EPIC-Potsdam cohort - role of fat assimilation. Mol Nutr Food Res. 2007;51:185-91 pubmed
    ..Six SNPs demonstrated nominal association with type 2 diabetes, with the most significant marker (FABP6 Thr79Met) having an adjusted odds ratio of 0.45 (95% CI 0.22-0.92) in homozygous Met allele carriers...
  44. Alizadehgharib S, Ostberg A, Dahlgren U. Triethylene glycol dimethacrylate: adjuvant properties and effect on cytokine production. Acta Biomater Odontol Scand. 2018;4:1-9 pubmed publisher
    ..This inflammatogenic capacity renders TEGDMAs adjuvant properties, which may interfere with the homeostasis between the immune system and the indigenous microflora in the oral cavity...
  45. Fujita M, Fujii H, Kanda T, Sato E, Hatakeyama K, Ono T. Molecular cloning, expression, and characterization of a human intestinal 15-kDa protein. Eur J Biochem. 1995;233:406-13 pubmed
    ..I-15P showed high similarity to the rat counterpart (78%), mouse ileal lipid-binding protein (80%) and porcine gastrotropin (75%). It also exhibited 36% similarity to human liver fatty-acid-binding protein (L-FABP)...
  46. Watanabe K, Hoshi N, Tsuura Y, Kanda T, Fujita M, Fujii H, et al. Immunohistochemical distribution of intestinal 15 kDa protein in human tissues. Arch Histol Cytol. 1995;58:303-6 pubmed
    The distribution of human intestinal 15 kDa protein (I-15P), a new fatty acid-binding protein (FABP), was observed in normal tissues using immunohistochemical techniques...
  47. Lucke C, Zhang F, Rüterjans H, Hamilton J, Sacchettini J. Flexibility is a likely determinant of binding specificity in the case of ileal lipid binding protein. Structure. 1996;4:785-800 pubmed
    ..proteins (LBPs) includes a large number of fatty acid binding proteins (FABPs) but only two proteins (ileal lipid binding protein, ILBP, and liver fatty acid binding protein) that can bind both fatty acids and bile acids...
  48. Grober J, Zaghini I, Fujii H, Jones S, Kliewer S, Willson T, et al. Identification of a bile acid-responsive element in the human ileal bile acid-binding protein gene. Involvement of the farnesoid X receptor/9-cis-retinoic acid receptor heterodimer. J Biol Chem. 1999;274:29749-54 pubmed
    ..In conclusion, we show that FXR is a physiological BA sensor that is likely to play an essential role in BA homeostasis through the regulation of genes involved in their enterohepatic circulation. ..
  49. Landrier J, Thomas C, Grober J, Zaghini I, Petit V, Poirier H, et al. The gene encoding the human ileal bile acid-binding protein (I-BABP) is regulated by peroxisome proliferator-activated receptors. Biochim Biophys Acta. 2005;1735:41-9 pubmed
    ..Our findings show that the I-BABP gene may be a novel target for PPAR in humans and further emphasize the role for PPAR in the control of bile acid homeostasis. ..
  50. Liu M, Liu C, Chen H, Huang X, Zeng X, Zhou J, et al. Prevention of cholesterol gallstone disease by schaftoside in lithogenic diet-induced C57BL/6 mouse model. Eur J Pharmacol. 2017;815:1-9 pubmed publisher
    ..mRNA expression of liver X receptor α, ATP binding cassette transporter 5/8 (ABCG5/8), and ileal bile acid binding protein (IBABP) in the ileum, and of farnesoid X receptor and bile salt export protein (BSEP) in the liver ..
  51. Horváth G, Egyed O, Toke O. Temperature dependence of backbone dynamics in human ileal bile acid-binding protein: implications for the mechanism of ligand binding. Biochemistry. 2014;53:5186-98 pubmed publisher
  52. D Onofrio M, Zanzoni S, Munari F, Monaco H, Assfalg M, Capaldi S. The long variant of human ileal bile acid-binding protein associated with colorectal cancer exhibits sub-cellular localization and lipid binding behaviour distinct from those of the common isoform. Biochim Biophys Acta Gen Subj. 2017;1861:2315-2324 pubmed publisher
    ..Our results constitute an essential first step towards an understanding of the role of IBABP-L in bile salt trafficking and signaling under healthy and pathological conditions. ..
  53. Alrefai W, Gill R. Bile acid transporters: structure, function, regulation and pathophysiological implications. Pharm Res. 2007;24:1803-23 pubmed
    ..Cytosolic ileal bile acid binding protein (IBABP) mediates the transcellular movement of bile acids to the basolateral membrane across which ..
  54. da Silva R, Cervigne N, Pinto C, da Cunha M, Rojas F, Peroni L, et al. Role of GAD peptides p217 and p290 in the repair of INS receptor in salivary tissues of type 1 diabetic mice. Pak J Pharm Sci. 2017;30:1545-1550 pubmed
    ..Our approach of combining GAD p217 and p290 peptides contributed to hormonal balance and promoted the repair of INS-R...
  55. Badiee M, Tochtrop G. Bile Acid Recognition by Mouse Ileal Bile Acid Binding Protein. ACS Chem Biol. 2017;: pubmed publisher
    b>Ileal bile acid binding protein (I-BABP, gene name FABP6) is a component of the bile acid recycling system, expressed in the ileal enterocyte...
  56. Fan W, Xia D, Zhu Q, Li X, He S, Zhu C, et al. Functional nanoparticles exploit the bile acid pathway to overcome multiple barriers of the intestinal epithelium for oral insulin delivery. Biomaterials. 2018;151:13-23 pubmed publisher
    ..9% in type I diabetic rats after loading freeze-dried DNPs into enteric-coated capsules. Thus, deoxycholic acid-modified chitosan nanoparticles can overcome multiple barriers of the intestinal epithelium for oral delivery of insulin. ..
  57. Kurz M, Brachvogel V, Matter H, Stengelin S, Thüring H, Kramer W. Insights into the bile acid transportation system: the human ileal lipid-binding protein-cholyltaurine complex and its comparison with homologous structures. Proteins. 2003;50:312-28 pubmed
    ..Here we report the solution structure of the human ileal lipid-binding protein (ILBP) in free form and in complex with cholyltaurine...
  58. Fallah A, Rezaee M, Hasani A, Barhaghi M, Kafil H. Frequency of bap and cpaA virulence genes in drug resistant clinical isolates of Acinetobacter baumannii and their role in biofilm formation. Iran J Basic Med Sci. 2017;20:849-855 pubmed publisher
    ..The aim of this work is to study antimicrobial resistance and the role of bap and cpaA genes in biofilm formation by A. baumannii to understand how this pathogen persists in the hospital environment...
  59. Korstanje R, Gillissen G, Kodde L, den Bieman M, Lankhorst A, van Zutphen L, et al. Mapping of microsatellite loci and association of aorta atherosclerosis with LG VI markers in the rabbit. Physiol Genomics. 2001;6:11-8 pubmed
    ..Three microsatellite markers (one anonymous, one located within the PMP2 gene, and one located within the FABP6 gene) constitute a new linkage group (LG XI)...
  60. Bergheim I, Harsch S, Mueller O, Schimmel S, Fritz P, Stange E. Apical sodium bile acid transporter and ileal lipid binding protein in gallstone carriers. J Lipid Res. 2006;47:42-50 pubmed
    ..A deficiency of the apical sodium bile acid transporter (ASBT) and ileal lipid binding protein (ILBP) in the small intestine may result in bile acid loss into the colon and might promote gallstone ..
  61. Ohmachi T, Inoue H, Mimori K, Tanaka F, Sasaki A, Kanda T, et al. Fatty acid binding protein 6 is overexpressed in colorectal cancer. Clin Cancer Res. 2006;12:5090-5 pubmed
    Fatty acid binding protein 6 (FABP6) is a cancer-related protein that acts as an intracellular transporter of bile acid in the ileal epithelium...
  62. Borchers T, Hohoff C, Buhlmann C, Spener F. Heart-type fatty acid binding protein - involvement in growth inhibition and differentiation. Prostaglandins Leukot Essent Fatty Acids. 1997;57:77-84 pubmed
    ..This argues against an active role of H-FABP in muscle development unlike the situation in the mammary gland. ..
  63. Fisher E, Grallert H, Klapper M, Pfäfflin A, Schrezenmeir J, Illig T, et al. Evidence for the Thr79Met polymorphism of the ileal fatty acid binding protein (FABP6) to be associated with type 2 diabetes in obese individuals. Mol Genet Metab. 2009;98:400-5 pubmed publisher
    The ileal fatty acid binding protein (FABP6) is known to be involved in enterohepatic bile acid metabolism...
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    ..Human ileal bile acid binding protein (I-BABP) is an intracellular carrier of bile salts in the epithelial cells of the distal small ..