FABP5

Summary

Gene Symbol: FABP5
Description: fatty acid binding protein 5
Alias: E-FABP, EFABP, KFABP, PA-FABP, PAFABP, fatty acid-binding protein, epidermal, epidermal-type fatty acid-binding protein, fatty acid binding protein 5 (psoriasis-associated), psoriasis-associated fatty acid-binding protein homolog
Species: human
Products:     FABP5

Top Publications

  1. Hohoff C, Borchers T, Rüstow B, Spener F, van Tilbeurgh H. Expression, purification, and crystal structure determination of recombinant human epidermal-type fatty acid binding protein. Biochemistry. 1999;38:12229-39 pubmed
    ..Cysteines 67 and 87 are also in close vicinity but in contrast do not form a disulfide bridge. We postulate that this protein belongs to a particular FABP subfamily whose members share common structural as well as functional features. ..
  2. Masouye I, Hagens G, van Kuppevelt T, Madsen P, Saurat J, Veerkamp J, et al. Endothelial cells of the human microvasculature express epidermal fatty acid-binding protein. Circ Res. 1997;81:297-303 pubmed
    ..These data suggest that E-FABP-mediated FA transport occurs at the level of the microvasculature in several FA target organs. ..
  3. Iwayama Y, Hattori E, Maekawa M, Yamada K, Toyota T, Ohnishi T, et al. Association analyses between brain-expressed fatty-acid binding protein (FABP) genes and schizophrenia and bipolar disorder. Am J Med Genet B Neuropsychiatr Genet. 2010;153B:484-493 pubmed publisher
    ..FABPs constitute a gene family, of which members FABP5 and FABP3 are also expressed in the brain...
  4. Maekawa M, Iwayama Y, Arai R, Nakamura K, Ohnishi T, Toyota T, et al. Polymorphism screening of brain-expressed FABP7, 5 and 3 genes and association studies in autism and schizophrenia in Japanese subjects. J Hum Genet. 2010;55:127-30 pubmed publisher
    ..SNPs), two are missense mutations, namely, 376G>C (Val126Leu) in FABP7 and 340G>C (Gly114Arg) in FABP5. Second, we tested for the genetic association of four missense SNPs with autism and schizophrenia, but failed to ..
  5. Liu R, Mita R, Beaulieu M, Gao Z, Godbout R. Fatty acid binding proteins in brain development and disease. Int J Dev Biol. 2010;54:1229-39 pubmed publisher
    ..Three of the ten mammalian FABPs identified to date (FABP3, FABP5, FABP7) are expressed in the brain...
  6. Kołodziejski P, Pruszyńska Oszmałek E, Strowski M, Nowak K. Long-term obestatin treatment of mice type 2 diabetes increases insulin sensitivity and improves liver function. Endocrine. 2017;56:538-550 pubmed publisher
    ..Obestatin influenced the expression of genes involved in lipid and carbohydrate metabolism by increasing Fabp5 and decreasing G6pc, Pepck, Fgf21 mRNA in the liver...
  7. Chen Y, Huang H, Xu C, Yu C, Li Y. Long Non-Coding RNA Profiling in a Non-Alcoholic Fatty Liver Disease Rodent Model: New Insight into Pathogenesis. Int J Mol Sci. 2017;18: pubmed publisher
    ..and FLRL7 showed a potential role in PPAR signaling pathway through interaction with fatty acid binding protein 5 (Fabp5), lipoprotein lipase (Lpl) and fatty acid desaturase 2 (Fads2)...
  8. Amato A, Caldara G, Nuzzo D, Baldassano S, Picone P, Rizzo M, et al. NAFLD and Atherosclerosis Are Prevented by a Natural Dietary Supplement Containing Curcumin, Silymarin, Guggul, Chlorogenic Acid and Inulin in Mice Fed a High-Fat Diet. Nutrients. 2017;9: pubmed publisher
    ..Ifng) and downregulation of some genes involved in pro-inflammatory response and in free fatty acid up-take (Fabp5, Socs3)...
  9. Moreno Castellanos N, Rodríguez A, Rabanal Ruiz Y, Fernández Vega A, López Miranda J, Vázquez Martínez R, et al. The cytoskeletal protein septin 11 is associated with human obesity and is involved in adipocyte lipid storage and metabolism. Diabetologia. 2017;60:324-335 pubmed publisher
    ..and interacted with both caveolin-1 and the intracellular fatty acid chaperone, fatty acid binding protein 5 (FABP5). Lipid loading of adipocytes caused the association of the three proteins with the surface of lipid droplets...

More Information

Publications148 found, 100 shown here

  1. Wang S, Gao H, Zhang J, Ye X. [Stable isotope labeling and parallel reaction monitoring-based proteomic quantification for biomarker screening and validation of hepatocellular carcinoma]. Se Pu. 2017;35:934-940 pubmed publisher
    ..the reported biomarker candidates Heat shock protein HSP 90-beta (HSP90), fatty acid-binding protein, epidermal (FABP5) and alcohol dehydrogenase 4 (ADH4), which demonstrated the robustness of the strategy...
  2. Massafra V, Milona A, Vos H, Burgering B, van Mil S. Quantitative liver proteomics identifies FGF19 targets that couple metabolism and proliferation. PLoS ONE. 2017;12:e0171185 pubmed publisher
    ..FGF19 treatment decreased the expression of proteins involved in fatty acid (FA) synthesis, i.e., Fabp5, Scd1, and Acsl3 and increased the expression of Acox1, involved in FA oxidation...
  3. Guo J, Lu W, Liang S, Choi J, Kim N, Cui X. Peroxisome proliferator-activated receptor ? improves porcine blastocyst hatching via the regulation of fatty acid oxidation. Theriogenology. 2017;90:266-275 pubmed publisher
    ..However, PPAR? activation enhanced lipid accumulation via Fabp3 and Fabp5. Fatty acid oxidation also increased in response to treatment with the agonist via the rate-limiting gene Cpt2...
  4. Zhou B, Zhang D, Liu X, Zhuang R, Zhang Y, Guo S. [Abnormal structure and dysfunction of platelets in CD226 knockout mice]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2018;34:309-314 pubmed
    ..Mass spectrometry indicated that platelet CD226 interacted with BDNF, FABP5, ApoA1 and other proteins...
  5. Urasaki Y, Zhang C, Cheng J, Le T. Quantitative Assessment of Liver Steatosis and Affected Pathways with Molecular Imaging and Proteomic Profiling. Sci Rep. 2018;8:3606 pubmed publisher
    ..Perturbations to the PTM profiles of Akt, 4EBP1, BID, HMGCS2, FABP1, and FABP5 indicated abnormalities in multiple cellular processes including cell cycle regulation, PI3K/Akt/mTOR signaling ..
  6. Li Y, Tian X, Wu M, Zheng X, Kong Q, Cheng X, et al. Resveratrol Suppresses the Growth and Enhances Retinoic Acid Sensitivity of Anaplastic Thyroid Cancer Cells. Int J Mol Sci. 2018;19: pubmed publisher
    ..capacity of resveratrol to overcome RA resistance in ATC cells by reprogramming CRABP2/RAR- and fatty acid-binding protein 5 (FABP5)/PPAR-?/?-mediated RA signaling, and (3) the redifferentiating potential of resveratrol in ATC cells.
  7. Guaita Esteruelas S, Bosquet A, Saavedra P, Gumà J, Girona J, Lam E, et al. Exogenous FABP4 increases breast cancer cell proliferation and activates the expression of fatty acid transport proteins. Mol Carcinog. 2017;56:208-217 pubmed publisher
    ..in MCF-7 cells increased levels of the transcription factor FoxM1 and the fatty acid transport proteins CD36 and FABP5. In summary, we showed that eFABP4 plays a key role in tumor proliferation and activates the expression of fatty ..
  8. Shang C, Wang W, Liao Y, Chen Y, Liu T, Du Q, et al. LNMICC Promotes Nodal Metastasis of Cervical Cancer by Reprogramming Fatty Acid Metabolism. Cancer Res. 2018;78:877-890 pubmed publisher
    ..fatty acid metabolism, by recruiting the nuclear factor NPM1 to the promoter of the fatty acid binding protein FABP5. We also found that the prometastatic effects of LNMICC were directly targeted and suppressed by miR-190...
  9. Nakamura H, Yamashita N, Kimura A, Kimura Y, Hirano H, Makihara H, et al. Comprehensive behavioral study and proteomic analyses of CRMP2-deficient mice. Genes Cells. 2016;21:1059-1079 pubmed publisher
    ..In addition, SNAP25, RAB18, FABP5, ARF5 and LDHA, which are related genes to schizophrenia and methamphetamine sensitization, are also decreased in ..
  10. Xie X, Zhao J, Xie L, Wang H, Xiao Y, She Y, et al. Identification of differentially expressed proteins in the injured lung from zinc chloride smoke inhalation based on proteomics analysis. Respir Res. 2019;20:36 pubmed publisher
    ..Finally, the injury repair-related proteins PARK7 and FABP5 were validated by immunohistochemistry and western blot analysis...
  11. Rao D, Phan D, Choo M, Weaver M, Oberley Deegan R, Bowler R, et al. Impact of fatty acid binding protein 5-deficiency on COPD exacerbations and cigarette smoke-induced inflammatory response to bacterial infection. Clin Transl Med. 2019;8:7 pubmed publisher
    ..e. COPD exacerbations). We have previously identified Fatty Acid Binding Protein 5 (FABP5) as an important anti-inflammatory protein in primary airway epithelial cells...
  12. Iso T, Haruyama H, Sunaga H, Matsui M, Matsui H, Tanaka R, et al. Exercise endurance capacity is markedly reduced due to impaired energy homeostasis during prolonged fasting in FABP4/5 deficient mice. BMC Physiol. 2019;19:1 pubmed publisher
    ..In mice deficient for FABP4 and FABP5 (double knockout (DKO) mice), FA utilization by red skeletal muscle and the heart is markedly reduced by the ..
  13. Li B, Qiao L, An L, Wang W, Liu J, Ren Y, et al. Transcriptome analysis of adipose tissues from two fat-tailed sheep breeds reveals key genes involved in fat deposition. BMC Genomics. 2018;19:338 pubmed publisher
    ..Of the 47 highly expressed co-genes, FABP4, ADIPOQ, FABP5, and CD36 were the four most highly transcribed genes among all the known genes related to adipose deposition...
  14. Nitschke K, Erben P, Waldbillig F, Abdelhadi A, Weis C, Gottschalt M, et al. Clinical relevance of gene expression in localized and metastatic prostate cancer exemplified by FABP5. World J Urol. 2019;: pubmed publisher
    Fatty acid-binding protein 5 (FABP5), a transport protein for lipophilic molecules, has been proposed as protein marker in prostate cancer (PCa). The role of FABP5 gene expression is merely unknown...
  15. Pan Y, Tian T, Park C, Lofftus S, Mei S, Liu X, et al. Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism. Nature. 2017;543:252-256 pubmed publisher
    ..that mediate lipid uptake and intracellular transport, including fatty-acid-binding proteins 4 and 5 (FABP4 and FABP5)...
  16. Hyder A, Zenhom M, Klapper M, Herrmann J, Schrezenmeir J. Expression of fatty acid binding proteins 3 and 5 genes in rat pancreatic islets and INS-1E cells: regulation by fatty acids and glucose. Islets. 2010;2:174-84 pubmed publisher
    ..Rat islets and INS-1E cells expressed the heart/muscle type (FABP3) and the epidermal type (FABP5) genes. Different FAs significantly enhanced the expression of both FABPs...
  17. Sanson B, Wang T, Sun J, Wang L, Kaczocha M, Ojima I, et al. Crystallographic study of FABP5 as an intracellular endocannabinoid transporter. Acta Crystallogr D Biol Crystallogr. 2014;70:290-8 pubmed publisher
    ..To understand how the endocannabinoids bind to FABPs, the crystal structures of FABP5 in complex with AEA, 2-AG and the inhibitor BMS-309403 were determined...
  18. Shinzawa M, Dogru M, Den S, Ichijima T, Higa K, Kojima T, et al. Epidermal Fatty Acid-Binding Protein: A Novel Marker in the Diagnosis of Dry Eye Disease in Sjögren Syndrome. Int J Mol Sci. 2018;19: pubmed publisher
    ..The E-FABP concentration in tears appears to be related to ocular surface epithelial damage and tear stability and may be a promising novel biomarker in the diagnosis of SS. ..
  19. Lu J, Cai S, Pan Y, Yun J. Altered epidermal fatty acid-binding protein expression in hepatocellular carcinoma predicts unfavorable outcomes. Cancer Manag Res. 2018;10:6275-6284 pubmed publisher
    ..Epidermal fatty acid-binding protein (EFABP) is uniquely expressed in epidermal cells, but its role and expression in HCC are not clear...
  20. Pan L, Xiao H, Liao R, Chen Q, Peng C, Zhang Y, et al. Fatty acid binding protein 5 promotes tumor angiogenesis and activates the IL6/STAT3/VEGFA pathway in hepatocellular carcinoma. Biomed Pharmacother. 2018;106:68-76 pubmed publisher
    ..Fatty acid binding protein 5(FABP5)is highly expressed in hepatocellular carcinoma (HCC)...
  21. Kaczocha M, Glaser S, Maher T, Clavin B, Hamilton J, O Rourke J, et al. Fatty acid binding protein deletion suppresses inflammatory pain through endocannabinoid/N-acylethanolamine-dependent mechanisms. Mol Pain. 2015;11:52 pubmed publisher
    ..Potential analgesic effects in mice lacking FABPs, however, have not been tested. Mice lacking FABP5 and FABP7, which exhibit highest affinities for endocannabinoids, possessed elevated levels of the endocannabinoid ..
  22. Li Z, Huang C, Bai S, Pan X, Zhou R, Wei Y, et al. Prognostic evaluation of epidermal fatty acid-binding protein and calcyphosine, two proteins implicated in endometrial cancer using a proteomic approach. Int J Cancer. 2008;123:2377-83 pubmed publisher
    ..CAPS might be a potential prognostic factor for survival in patients with EC. The research pattern from proteomics to clinical specimens would have widespread applications. ..
  23. Zhang Y, Hao J, Zeng J, Li Q, Rao E, Sun Y, et al. Epidermal FABP Prevents Chemical-Induced Skin Tumorigenesis by Regulation of TPA-Induced IFN/p53/SOX2 Pathway in Keratinocytes. J Invest Dermatol. 2018;138:1925-1934 pubmed publisher
    ..Collectively, our data suggest an unknown function of E-FABP in prevention of skin tumor development, and offer E-FABP as a therapeutic target for improving skin innate immunity in chemical-induced skin tumor prevention. ..
  24. Thulasiraman P, McAndrews D, Mohiudddin I. Curcumin restores sensitivity to retinoic acid in triple negative breast cancer cells. BMC Cancer. 2014;14:724 pubmed publisher
    ..acid facilitates the growth of mammary carcinoma cells which express high levels of fatty acid-binding protein 5 (FABP5)...
  25. Senga S, Kobayashi N, Kawaguchi K, Ando A, Fujii H. Fatty acid-binding protein 5 (FABP5) promotes lipolysis of lipid droplets, de novo fatty acid (FA) synthesis and activation of nuclear factor-kappa B (NF-κB) signaling in cancer cells. Biochim Biophys Acta Mol Cell Biol Lipids. 2018;1863:1057-1067 pubmed publisher
    ..Epidermal fatty acid-binding protein (FABP5) is an intracellular lipid-binding protein that is abundantly expressed in adipocytes and macrophages...
  26. Matsumata M, Inada H, Osumi N. Fatty acid binding proteins and the nervous system: Their impact on mental conditions. Neurosci Res. 2016;102:47-55 pubmed publisher
    ..Among Fabp family molecules, Fabp3, Fabp5, and Fabp7 are specifically localized in neural stem/progenitor cells, neurons and glia in a cell-type specific ..
  27. Li B, Schmidt N. Epidermal Fatty Acid Binding Protein (E-FABP) Is Not Required for the Generation or Maintenance of Effector and Memory T Cells following Infection with Listeria monocytogenes. PLoS ONE. 2016;11:e0162427 pubmed publisher
    ..These data demonstrate that E-FABP is dispensable for antigen-specific T cell responses following a bacterial infection. ..
  28. Powell C, Nasser M, Zhao H, Wochna J, Zhang X, Shapiro C, et al. Fatty acid binding protein 5 promotes metastatic potential of triple negative breast cancer cells through enhancing epidermal growth factor receptor stability. Oncotarget. 2015;6:6373-85 pubmed
    Fatty acid binding protein 5 (FABP5), an intracellular lipid binding protein, has been shown to play a role in various cancers, including breast cancer...
  29. Guo Z, Hu Q, Tian J, Yan L, Jing C, Xie H, et al. Proteomic profiling reveals candidate markers for arsenic-induced skin keratosis. Environ Pollut. 2016;218:34-38 pubmed publisher
    ..The expression of keratin 6c (KRT6C) and fatty acid binding protein 5 (FABP5) were significantly increased...
  30. Yan S, Elmes M, Tong S, Hu K, Awwa M, Teng G, et al. SAR studies on truxillic acid mono esters as a new class of antinociceptive agents targeting fatty acid binding proteins. Eur J Med Chem. 2018;154:233-252 pubmed publisher
    ..2 program, using the recently determined co-crystal structures of 3 with FABP5 and FABP7...
  31. Islam A, Kagawa Y, Sharifi K, Ebrahimi M, Miyazaki H, Yasumoto Y, et al. Fatty Acid Binding Protein 3 Is Involved in n-3 and n-6 PUFA transport in mouse trophoblasts. J Nutr. 2014;144:1509-16 pubmed publisher
    ..Four FABPs (FABP3, FABP4, FABP5, and FABP7) were expressed with spatial heterogeneity in the placenta, and FABP3 was dominantly localized to the ..
  32. Möck A, Warta R, Geisenberger C, Bischoff R, Schulte A, Lamszus K, et al. Printed peptide arrays identify prognostic TNC serumantibodies in glioblastoma patients. Oncotarget. 2015;6:13579-90 pubmed
    ..were screened for prognostic antibodies against 1745 13-mer peptides covering known TAAs (TNC, EGFR, GLEA2, PHF3, FABP5, MAGEA3)...
  33. Pan Y, Short J, Choy K, Zeng A, Marriott P, Owada Y, et al. Fatty Acid-Binding Protein 5 at the Blood-Brain Barrier Regulates Endogenous Brain Docosahexaenoic Acid Levels and Cognitive Function. J Neurosci. 2016;36:11755-11767 pubmed
    Fatty acid-binding protein 5 (FABP5) at the blood-brain barrier contributes to the brain uptake of docosahexaenoic acid (DHA), a blood-derived polyunsaturated fatty acid essential for maintenance of cognitive function...
  34. Baumeier C, Kaiser D, Heeren J, Scheja L, John C, Weise C, et al. Caloric restriction and intermittent fasting alter hepatic lipid droplet proteome and diacylglycerol species and prevent diabetes in NZO mice. Biochim Biophys Acta. 2015;1851:566-76 pubmed publisher
    ..inhibitor factor), TCEB2 (transcription elongation factor B (SIII), polypeptide 2), ACY1 (aminoacylase 1) and FABP5 (fatty acid binding protein 5), and a marked reduction of GSTA3 (glutathione S-transferase alpha 3) in samples of ..
  35. Wang X, Bai J, Jia Z, Zhu Y, Liu J, Zhang K, et al. A time-course microarray data analysis reveals consistent dysregulated genes and upstream microRNAs in autoantibody-mediated arthritis. J Orthop Surg Res. 2017;12:186 pubmed publisher
    ..downregulated Ephx1 and upregulated AF251705, Adam8, Arg1, Basp1, Ccl2, Ccl7, Ccl9, Ccr2, Clec4a2, Clec4d, Cxcl1, Fabp5, Fcgr1, Gp49a, Il1rn, and Saa3...
  36. Sommer C, Mostoslavsky G. RNA-Seq analysis of enteroendocrine cells reveals a role for FABP5 in the control of GIP secretion. Mol Endocrinol. 2014;28:1855-65 pubmed publisher
    ..the genes differentially expressed in GIP(GFP) cells, we identified and validated fatty acid-binding protein 5 (FABP5) as a highly expressed marker of GIP-producing cells that is absent in other enteroendocrine cell types...
  37. Peng X, Studholme K, Kanjiya M, Luk J, Bogdan D, Elmes M, et al. Fatty-acid-binding protein inhibition produces analgesic effects through peripheral and central mechanisms. Mol Pain. 2017;13:1744806917697007 pubmed publisher
    ..Previous work indicates that systemically administered FABP5 inhibitors produce analgesia in models of inflammatory pain...
  38. Wang X, Shao F, Yu J, Jiang H, Gong D, Gu Z. MicroRNA-122 targets genes related to liver metabolism in chickens. Comp Biochem Physiol B Biochem Mol Biol. 2015;184:29-35 pubmed publisher
    ..By bioinformatics and reporter gene analyses, we identified PKM2, TGFB3, FABP5 and ARCN1 as miR-122 target genes in the chicken liver...
  39. Rao E, Singh P, Li Y, Zhang Y, Chi Y, Suttles J, et al. Targeting epidermal fatty acid binding protein for treatment of experimental autoimmune encephalomyelitis. BMC Immunol. 2015;16:28 pubmed publisher
    ..Taken together, we have identified a new compound which displays a potential therapeutic benefit for treatment of MS by targeting E-FABP. ..
  40. Pélerin H, Jouin M, Lallemand M, Alessandri J, Cunnane S, Langelier B, et al. Gene expression of fatty acid transport and binding proteins in the blood-brain barrier and the cerebral cortex of the rat: differences across development and with different DHA brain status. Prostaglandins Leukot Essent Fatty Acids. 2014;91:213-20 pubmed publisher
    ..In control rats, all the genes were expressed at the BBB level (P14 to P60), the mRNA levels of FABP5 and ACSL3 having the highest values...
  41. Bando Y, Sakashita H, Taira F, Miyake G, Ogasawara Y, Sakiyama K, et al. Origin and development of septoclasts in endochondral ossification of mice. Histochem Cell Biol. 2018;149:645-654 pubmed publisher
    ..We have previously revealed a selective expression of epidermal-type fatty acid-binding protein (E-FABP/FABP5) in septoclasts...
  42. Guaita Esteruelas S, Guma J, Masana L, Borras J. The peritumoural adipose tissue microenvironment and cancer. The roles of fatty acid binding protein 4 and fatty acid binding protein 5. Mol Cell Endocrinol. 2018;462:107-118 pubmed publisher
    ..Adipose-derived FABPs include FABP4 and FABP5. Both have an important role in lipid-related metabolic processes and overexpressed in many cancers, such as ..
  43. Moore S, Holt V, Malpass L, Hines I, Wheeler M. Fatty acid-binding protein 5 limits the anti-inflammatory response in murine macrophages. Mol Immunol. 2015;67:265-75 pubmed publisher
    ..The intracellular lipid transporter, fatty acid binding protein 5 (FABP5), is highly expressed in macrophages and may play an important role in the hepatic inflammatory response after ..
  44. Yan F, Liu X, Zhang S, Su J, Zhang Q, Chen J. Molecular Dynamics Exploration of Selectivity of Dual Inhibitors 5M7, 65X, and 65Z toward Fatty Acid Binding Proteins 4 and 5. Int J Mol Sci. 2018;19: pubmed publisher
    Designing highly selective inhibitors of fatty acid binding proteins 4 and 5 (FABP4 and FABP5) is of importance for treatment of some diseases related with inflammation, metabolism, and tumor growth...
  45. Ruse M, Broome A, Eckert R. S100A7 (psoriasin) interacts with epidermal fatty acid binding protein and localizes in focal adhesion-like structures in cultured keratinocytes. J Invest Dermatol. 2003;121:132-41 pubmed
    ..The colocalization with alpha-actinin and paxillin suggests that S100A7 and epidermal fatty acid binding protein colocalize in focal adhesion-like structures following calcium treatment. ..
  46. Zhang Y, Li Q, Rao E, Sun Y, Grossmann M, Morris R, et al. Epidermal Fatty Acid binding protein promotes skin inflammation induced by high-fat diet. Immunity. 2015;42:953-964 pubmed publisher
    ..Furthermore, E-FABP-deficient mice are completely resistant to HFD-induced skin lesions. Collectively, E-FABP represents a molecular sensor triggering HFD-induced skin inflammation. ..
  47. Tomazic P, Birner Gruenberger R, Leitner A, Spoerk S, Lang Loidolt D. Seasonal proteome changes of nasal mucus reflect perennial inflammatory response and reduced defence mechanisms and plasticity in allergic rhinitis. J Proteomics. 2016;133:153-160 pubmed publisher
    ..1-fold) were significantly less abundant in season. In healthy controls UBC, TUBA1B, HBB and FABP5 were only present in season. Ig kappa chain V-I region DEE (5.3-fold), CLU (5.0-fold), TXN (4.3-fold), MSMB (3...
  48. Shibue K, Yamane S, Harada N, Hamasaki A, Suzuki K, Joo E, et al. Fatty acid-binding protein 5 regulates diet-induced obesity via GIP secretion from enteroendocrine K cells in response to fat ingestion. Am J Physiol Endocrinol Metab. 2015;308:E583-91 pubmed publisher
    ..A recent study shows that fatty acid-binding protein 5 (FABP5) is expressed in murine K cells and is involved in fat-induced GIP secretion...
  49. Hou Q, Bing Z, Hu C, Li M, Yang K, Mo Z, et al. RankProd Combined with Genetic Algorithm Optimized Artificial Neural Network Establishes a Diagnostic and Prognostic Prediction Model that Revealed C1QTNF3 as a Biomarker for Prostate Cancer. EBioMedicine. 2018;32:234-244 pubmed publisher
    ..808) of PCa in the TCGA database. The expression levels of three genes, FABP5, C1QTNF3 and LPHN3, were validated by qPCR...
  50. Zeng J, Zhang Y, Hao J, Sun Y, Liu S, Bernlohr D, et al. Stearic Acid Induces CD11c Expression in Proinflammatory Macrophages via Epidermal Fatty Acid Binding Protein. J Immunol. 2018;200:3407-3419 pubmed publisher
    ..Altogether, our data demonstrate a novel mechanism by which saturated FAs promote obesity-associated inflammation through inducing E-FABP/retinoid acid receptor-mediated differentiation of CD11c+ macrophages. ..
  51. Zhang F, Chen Y, Long J, Dong L, Wang Y, Chen Y. Dietary fatty acids affect lipid metabolism and estrogen receptor expression in N-methyl-N-nitrosourea-induced rat mammary cancer model. Clin Lab. 2015;61:389-95 pubmed
    ..that dietary polyunsaturated fatty acids (PUFA) could affect the expression of serum fatty acid binding protein 5 (FABP5) and CD36 levels and also fatty acid synthase (FAS), and estrogen receptor (ER) expressions in breast cancer cells...
  52. Abel M, Baban D, Lee S, Charlton H, O Shaughnessy P. Effects of FSH on testicular mRNA transcript levels in the hypogonadal mouse. J Mol Endocrinol. 2009;42:291-303 pubmed publisher
    ..At 12 h, there was a clear increase in the levels of a number of known Sertoli cell transcripts (e.g. Fabp5, Lgals1, Tesc, Scara5, Aqp5). Additionally, levels of Leydig cell transcripts were also markedly increased (e.g...
  53. Temma T, Nishigori K, Onoe S, Sampei S, Kimura I, Ono M, et al. Radiofluorinated probe for PET imaging of fatty acid binding protein 4 in cancer. Nucl Med Biol. 2015;42:184-91 pubmed publisher
    ..After radiosynthesis, [(18)F]FTAP1 affinity and selectivity were evaluated using immobilized FABP3, FABP4, and FABP5. Cell uptake was investigated using differentiated adipocytes expressing FABP4 with inhibitor treatment...
  54. Igoh A, Doi Y, Sakurada K. Identification and evaluation of potential forensic marker proteins in vaginal fluid by liquid chromatography/mass spectrometry. Anal Bioanal Chem. 2015;407:7135-44 pubmed publisher
    ..vaginal samples: two human small proline-rich protein 3 (SPRR3) isoforms and a human fatty acid-binding protein 5 (FABP5) with an acetylated (+42) N-terminal region lacking the initiator methionine residue (-131)...
  55. Mosquera N, Rodríguez Trillo A, Mera Varela A, Gonzalez A, Conde C. Uncovering Cellular retinoic acid-binding protein 2 as a potential target for rheumatoid arthritis synovial hyperplasia. Sci Rep. 2018;8:8731 pubmed publisher
    ..Specifically, we investigated the role of retinoids and of the retinoic acid binding proteins, CRABP2 and FABP5, on the proliferation and apoptosis of FLS from RA by adding all-trans retinoic acid (ATRA) or silencing CRABP2 ..
  56. Yang D, Li Y, Xing L, Tan Y, Sun J, Zeng B, et al. Utilization of adipocyte-derived lipids and enhanced intracellular trafficking of fatty acids contribute to breast cancer progression. Cell Commun Signal. 2018;16:32 pubmed publisher
    ..cancer cells were measured, as well as the expression of the rate-limiting lipase ATGL and fatty acid transporter FABP5. ATGL and FABP5 were then ablated to investigate their impact on the aggressiveness of breast cancer cells that ..
  57. Miyake T, Ogawa E, Mikoshiba A, Kobayashi A, Hosoe H, Kashiwabara S, et al. Epidermal-type FABP is a predictive marker of clinical response to systemic treatment and ultraviolet therapy in psoriatic skin lesions. J Dermatol Sci. 2012;68:199-202 pubmed publisher
  58. Ozaki R, Kuroda K, Ikemoto Y, Ochiai A, Matsumoto A, Kumakiri J, et al. Reprogramming of the retinoic acid pathway in decidualizing human endometrial stromal cells. PLoS ONE. 2017;12:e0173035 pubmed publisher
    ..Differentiating HESCs downregulate the intracellular carrier proteins CRABP2 and FABP5, responsible for transfer and binding of RA to the nuclear receptors RAR and PPARβ/δ, respectively...
  59. Umbarawan Y, Syamsunarno M, Obinata H, Yamaguchi A, Sunaga H, Matsui H, et al. Robust suppression of cardiac energy catabolism with marked accumulation of energy substrates during lipopolysaccharide-induced cardiac dysfunction in mice. Metabolism. 2017;77:47-57 pubmed publisher
    ..from FAs to glucose, and increased hepatic ketogenesis in mice lacking fatty acid-binding protein 4 (FABP4) and FABP5 (DKO)...
  60. Noy N. Non-classical Transcriptional Activity of Retinoic Acid. Subcell Biochem. 2016;81:179-199 pubmed
    ..proteins: cellular RA binding protein 2 (CRABP2) delivers RA to nuclear RARs and a fatty acid binding protein (FABP5) delivers the hormone from the cytosol to nuclear PPAR?/?...
  61. Forootan F, Forootan S, Malki M, Chen D, Li G, Lin K, et al. The expression of C-FABP and PPAR? and their prognostic significance in prostate cancer. Int J Oncol. 2014;44:265-75 pubmed publisher
    ..Both C-FABP and PPAR? are suitable as prognostic factors to predict the clinical outcome of prostatic cancer patients. ..
  62. Zhou N, Yao Y, Ye H, Zhu W, Chen L, Mao Y. Abscisic-acid-induced cellular apoptosis and differentiation in glioma via the retinoid acid signaling pathway. Int J Cancer. 2016;138:1947-58 pubmed publisher
    ..2 (CRABP2) and a negative correlation between the ABA levels and transcription of fatty acid-binding protein 5 (FABP5)...
  63. Kawaguchi K, Senga S, Kubota C, Kawamura Y, Ke Y, Fujii H. High expression of Fatty Acid-Binding Protein 5 promotes cell growth and metastatic potential of colorectal cancer cells. FEBS Open Bio. 2016;6:190-9 pubmed publisher
    ..The present study demonstrates that the FABP5 gene is upregulated in colorectal cancer cells compared to normal colon cells in a manner that correlates with ..
  64. Song J, Zhang H, Wang Z, Xu W, Zhong L, Cao J, et al. The Role of FABP5 in Radiation-Induced Human Skin Fibrosis. Radiat Res. 2017;: pubmed publisher
    ..expressed proteins included keratins (KRT5, KRT6A, KRT16 and KRT17), caspase-14, fatty acid-binding protein 5 (FABP5), SLC2A14 and resistin...
  65. Bogdan D, Falcone J, Kanjiya M, Park S, Carbonetti G, Studholme K, et al. Fatty acid-binding protein 5 controls microsomal prostaglandin E synthase 1 (mPGES-1) induction during inflammation. J Biol Chem. 2018;293:5295-5306 pubmed publisher
    ..proteins (FABPs) are intracellular lipid carriers that regulate inflammation, and pharmacological inhibition of FABP5 reduces inflammation and pain...
  66. Liu R, Garcia E, Glubrecht D, Poon H, Mackey J, Godbout R. CRABP1 is associated with a poor prognosis in breast cancer: adding to the complexity of breast cancer cell response to retinoic acid. Mol Cancer. 2015;14:129 pubmed publisher
    ..The expression and subcellular distribution of two RA-binding proteins, FABP5 and CRABP2, has already been shown to play critical roles in breast cancer cell response to RA...
  67. Yu C, Liang X, Lipsky S, Karaaslan C, Kozakewich H, Hotamisligil G, et al. Dual role of fatty acid-binding protein 5 on endothelial cell fate: a potential link between lipid metabolism and angiogenic responses. Angiogenesis. 2016;19:95-106 pubmed publisher
    ..FABP4 and FABP5 share ~55 % amino acid sequence homology and demonstrate synergistic effects in regulation of metabolic and ..
  68. Al Fayi M, Gou X, Forootan S, Al Jameel W, Bao Z, Rudland P, et al. The increased expression of fatty acid-binding protein 9 in prostate cancer and its prognostic significance. Oncotarget. 2016;7:82783-82797 pubmed publisher
    In contrast to numerous studies conducted to investigate the crucial role of fatty acid binding protein 5 (FABP5) in prostate cancer, investigations on the possible involvement of other FABPs are rare...
  69. Jeong C, Hah Y, Cho B, Lee S, Joo Y, Jung E, et al. Fatty acid-binding protein 5 promotes cell proliferation and invasion in human intrahepatic cholangiocarcinoma. Oncol Rep. 2012;28:1283-92 pubmed publisher
    ..Of these, increased expression of fatty acid-binding protein 5 (FABP5) was further confirmed by western blot analysis and immunohistochemical analysis...
  70. Zhang W, Levi L, Banerjee P, Jain M, Noy N. Kruppel-like factor 2 suppresses mammary carcinoma growth by regulating retinoic acid signaling. Oncotarget. 2015;6:35830-42 pubmed publisher
    ..cellular retinoic acid-binding protein 2 (CRABP2), which delivers RA to RARs, and fatty acid-binding protein 5 (FABP5), which shuttles ligands to PPARβ/δ...
  71. Bando Y, Yamamoto M, Sakiyama K, Sakashita H, Taira F, Miyake G, et al. Retinoic acid regulates cell-shape and -death of E-FABP (FABP5)-immunoreactive septoclasts in the growth plate cartilage of mice. Histochem Cell Biol. 2017;148:229-238 pubmed publisher
    ..We previously reported the expression of epidermal-type fatty acid-binding protein (E-FABP, FABP5) and localization of peroxisome proliferator-activated receptor (PPAR)?/?, which mediates the cell survival or ..
  72. Xia S, Shao J, Zhao S, Qiu Y, Teng L, Huang W, et al. Niga-ichigoside F1 ameliorates high-fat diet-induced hepatic steatosis in male mice by Nrf2 activation. Food Funct. 2018;9:906-916 pubmed publisher
    ..interacting with HFD to regulate lipid metabolism genes (including Srebp1c, Acc1, Fasn, Scd1, Cpt1a and Fabp5)...
  73. Deiuliis J, Shin J, Murphy E, Kronberg S, Eastridge M, Suh Y, et al. Bovine adipose triglyceride lipase is not altered and adipocyte fatty acid-binding protein is increased by dietary flaxseed. Lipids. 2010;45:963-73 pubmed publisher
    ..of flaxseed supplementation on ATGL and adipocyte fatty acid-binding protein (FABP4 or A-FABP, E-FABP or FABP5) expression was examined in Angus steers...
  74. Tsai Y, Wu S, Huang H, Ma D, Wang N, Hsiao C, et al. Expression of retinoic acid-binding proteins and retinoic acid receptors in sebaceous cell carcinoma of the eyelids. BMC Ophthalmol. 2015;15:142 pubmed publisher
    ..acid binding protein 1 (CRABP1), cellular retinoic acid binding protein 2 (CRABP2), fatty acid-binding protein 5 (FABP5), retinoic acid receptors (RAR-α, -β, -γ), and retinoid X receptors (RXR-α, -β, -γ) was ..
  75. Li Q, You C, Zhou L, Sima X, Liu Z, Liu H, et al. High FABP5 Versus CRABPII Expression Ratio in Recurrent Craniopharyngiomas: Implications for Future Treatment. World Neurosurg. 2016;94:197-205 pubmed publisher
    Recurrence is a major problem in craniopharyngioma (CP) management. Recent study shows that high FABP5/CRABPII may be related to tumor growth and that all-trans retinoic acid (ATRA) may suppress primary CP growth...
  76. Kühne H, Obst Sander U, Kuhn B, Conte A, Ceccarelli S, Neidhart W, et al. Design and synthesis of selective, dual fatty acid binding protein 4 and 5 inhibitors. Bioorg Med Chem Lett. 2016;26:5092-5097 pubmed publisher
    Dual inhibition of fatty acid binding proteins 4 and 5 (FABP4 and FABP5) is expected to provide beneficial effects on a number of metabolic parameters such as insulin sensitivity and blood glucose levels and should protect against ..
  77. Napoli J. Cellular retinoid binding-proteins, CRBP, CRABP, FABP5: Effects on retinoid metabolism, function and related diseases. Pharmacol Ther. 2017;173:19-33 pubmed publisher
    Cellular binding-proteins (BP), including CRBP1, CRBP2, CRABP1, CRABP2, and FABP5, shepherd the poorly aqueous soluble retinoids during uptake, metabolism and function...
  78. Pavone M, Malpani S, Dyson M, Kim J, Bulun S. Fenretinide: A Potential Treatment for Endometriosis. Reprod Sci. 2016;23:1139-47 pubmed publisher
    ..including stimulated by RA 6 (STRA6), cellular RA binding protein 2 (CRABP2), and fatty acid binding protein 5 (FABP5)...
  79. Furuhashi M, Ogura M, Matsumoto M, Yuda S, Muranaka A, Kawamukai M, et al. Serum FABP5 concentration is a potential biomarker for residual risk of atherosclerosis in relation to cholesterol efflux from macrophages. Sci Rep. 2017;7:217 pubmed publisher
    ..Fatty acid-binding protein 4 (FABP4) and FABP5 are expressed in both adipocytes and macrophages and play significant roles in the development of insulin ..
  80. Guaita Esteruelas S, Saavedra García P, Bosquet A, Borras J, Girona J, Amiliano K, et al. Adipose-Derived Fatty Acid-Binding Proteins Plasma Concentrations Are Increased in Breast Cancer Patients. Oncologist. 2017;22:1309-1315 pubmed publisher
    ..The role of adipose-derived fatty acid-binding protein (FABP) 4 and FABP5 in breast cancer is presently under study, but their circulating levels in this pathology are poorly known...
  81. Napoli J. Functions of Intracellular Retinoid Binding-Proteins. Subcell Biochem. 2016;81:21-76 pubmed
    ..Intracellular retinoic acid binding-proteins (CRABP1 and 2, and FABP5) seem to have more diverse functions distinctive to each, such as directing retinoic acid to catabolism, ..
  82. Asimakopoulou A, Fulop A, Borkham Kamphorst E, de Leur E, Gassler N, Berger T, et al. Altered mitochondrial and peroxisomal integrity in lipocalin-2-deficient mice with hepatic steatosis. Biochim Biophys Acta Mol Basis Dis. 2017;1863:2093-2110 pubmed publisher
    ..Label-free proteomics and 2D-DIGE protein expression profiling revealed differential expression of BRIT1/MCPH1, FABP5, HMGB1, HBB2, and L-FABP, results confirmed by Western blotting...
  83. Haj Dahmane S, Shen R, Elmes M, Studholme K, Kanjiya M, Bogdan D, et al. Fatty-acid-binding protein 5 controls retrograde endocannabinoid signaling at central glutamate synapses. Proc Natl Acad Sci U S A. 2018;115:3482-3487 pubmed publisher
    ..Here, we demonstrate that fatty-acid-binding protein 5 (FABP5), a canonical intracellular carrier of eCBs, is indispensable for retrograde eCB transport in the dorsal raphe ..
  84. Ha M, Chung K, Lee J, Bang D, Park Y, Lee K. Expression of psoriasis-associated fatty acid-binding protein in senescent human dermal microvascular endothelial cells. Exp Dermatol. 2004;13:543-50 pubmed
    ..Our results suggest that the overexpression of FABP in cultured senescent HDMECs is closely related to skin aging. ..
  85. Siegenthaler G, Hotz R, Chatellard Gruaz D, Didierjean L, Hellman U, Saurat J. Purification and characterization of the human epidermal fatty acid-binding protein: localization during epidermal cell differentiation in vivo and in vitro. Biochem J. 1994;302 ( Pt 2):363-71 pubmed
    ..The presence of E-FABP in tissues other than skin (heart, intestine and adipose tissue) excludes its specific role in fatty acid metabolism in epithelial cells or its involvement in skin lipid-barrier function. ..
  86. Watanabe R, Fujii H, Yamamoto A, Hashimoto T, Kameda K, Ito M, et al. Immunohistochemical distribution of cutaneous fatty acid-binding protein in human skin. J Dermatol Sci. 1997;16:17-22 pubmed
    ..Moreover, it is suggested that C-FABP has important roles in the transport and metabolism of fatty acids in epidermis and that altered lipid metabolism may affect the proliferation and/or differentiation of keratinocyte. ..
  87. Li H, Lu Q, Dong L, Xue H, Zhou H, Yang H. [Expression of fatty acid binding protein in human breast cancer tissues]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2007;23:312-6 pubmed
    ..E-, L-, and H-FABP may play a key role in the progress of invasiveness and metastasis in human breast cancer. Furthermore, the secretion of these FABPs has the potential to serve as a diagnostic marker for breast cancer. ..
  88. Han Q, Yeung S, Ip M, Mak J. Effects of intermittent hypoxia on A-/E-FABP expression in human aortic endothelial cells. Int J Cardiol. 2010;145:396-398 pubmed publisher
  89. Liu J, Zeng Y, Zhou Y, Ma D, Wang B. Proteomic expression analysis of mycosis fungoides (MF) skin tissues: overexpressions of SOD2, S100A8 and FABP5 in MF. J Dermatol Sci. 2010;60:42-4 pubmed publisher
  90. Hong J, Gu W, Zhang Y, Yan Q, Dai M, Shi J, et al. Different association of circulating levels of adipocyte and epidermal fatty acid-binding proteins with metabolic syndrome and coronary atherosclerosis in Chinese adults. Atherosclerosis. 2011;217:194-200 pubmed publisher
    ..05). Our data indicated while both serum A-FABP and E-FABP levels had associations with MetS, only A-FABP was significantly associated with increased risk of CAD in Chinese adults. ..
  91. Syamsunarno M, Iso T, Hanaoka H, Yamaguchi A, Obokata M, Koitabashi N, et al. A critical role of fatty acid binding protein 4 and 5 (FABP4/5) in the systemic response to fasting. PLoS ONE. 2013;8:e79386 pubmed publisher
    ..We recently showed that FA binding protein 4 (FABP4) and FABP5, which are abundantly expressed in adipocytes and macrophages, are prominently expressed in capillary endothelial ..
  92. Xia S, Wu M, Li H, Wang J, Chen N, Chen X, et al. CRABP-II- and FABP5-independent responsiveness of human glioblastoma cells to all-trans retinoic acid. Oncotarget. 2015;6:5889-902 pubmed
    Glioblastomas respond differently to all-trans retinoic acid (RA) for unknown reasons. Because CRABP-II and FABP5 mediate RA intracellular signaling respectively and lead to distinct biological consequences, their expression patterns in ..