FABP4

Summary

Gene Symbol: FABP4
Description: fatty acid binding protein 4
Alias: A-FABP, AFABP, ALBP, HEL-S-104, aP2, fatty acid-binding protein, adipocyte, adipocyte fatty acid binding protein, adipocyte lipid-binding protein, adipocyte-type fatty acid-binding protein, epididymis secretory protein Li 104, fatty acid binding protein 4, adipocyte
Species: human
Products:     FABP4

Top Publications

  1. Tsai J, Liou H, Liu H, Lee C, Lee R, Hsu B. Fasting serum fatty acid-binding protein 4 level positively correlates with metabolic syndrome in hemodialysis patients. Arch Med Res. 2010;41:536-40 pubmed publisher
    Serum fatty acid-binding protein 4 (FABP4) level increases in patients with metabolic syndrome (MetS). The interrelationships between fasting FABP4 levels and MetS have not been analyzed in hemodialysis (HD) patients...
  2. Elmasri H, Ghelfi E, Yu C, Traphagen S, Cernadas M, Cao H, et al. Endothelial cell-fatty acid binding protein 4 promotes angiogenesis: role of stem cell factor/c-kit pathway. Angiogenesis. 2012;15:457-68 pubmed publisher
    Fatty acid binding protein 4 (FABP4) plays an important role in regulation of glucose and lipid homeostasis as well as inflammation through its actions in adipocytes and macrophages...
  3. Ota H, Furuhashi M, Ishimura S, Koyama M, Okazaki Y, Mita T, et al. Elevation of fatty acid-binding protein 4 is predisposed by family history of hypertension and contributes to blood pressure elevation. Am J Hypertens. 2012;25:1124-30 pubmed publisher
    Fatty acid-binding protein 4 (FABP4/A-FABP/aP2), a lipid chaperone, is expressed in both adipocytes and macrophages...
  4. Holm S, Ueland T, Dahl T, Michelsen A, Skjelland M, Russell D, et al. Fatty Acid binding protein 4 is associated with carotid atherosclerosis and outcome in patients with acute ischemic stroke. PLoS ONE. 2011;6:e28785 pubmed publisher
    Fatty acid binding protein 4 (FABP4) has been shown to play an important role in macrophage cholesterol trafficking and associated inflammation...
  5. Han Q, Yeung S, Ip M, Mak J. Effects of intermittent hypoxia on A-/E-FABP expression in human aortic endothelial cells. Int J Cardiol. 2010;145:396-398 pubmed publisher
  6. Smith A, Thompson B, Sanders M, Bernlohr D. Interaction of the adipocyte fatty acid-binding protein with the hormone-sensitive lipase: regulation by fatty acids and phosphorylation. J Biol Chem. 2007;282:32424-32 pubmed
    Adipocyte fatty acid-binding protein (AFABP/aP2) forms a physical complex with the hormone-sensitive lipase (HSL) and AFABP/aP2-null mice exhibit reduced basal and hormone-stimulated lipolysis...
  7. Engeli S, Utz W, Haufe S, Lamounier Zepter V, Pofahl M, Traber J, et al. Fatty acid binding protein 4 predicts left ventricular mass and longitudinal function in overweight and obese women. Heart. 2013;99:944-8 pubmed publisher
    To explore whether increased adipocyte-derived serum fatty acid binding protein 4 (FABP4) predisposes to cardiac remodelling and left ventricular dysfunction in human obesity. Cross-sectional investigation...
  8. Hong J, Gu W, Zhang Y, Yan Q, Dai M, Shi J, et al. Different association of circulating levels of adipocyte and epidermal fatty acid-binding proteins with metabolic syndrome and coronary atherosclerosis in Chinese adults. Atherosclerosis. 2011;217:194-200 pubmed publisher
    ..05). Our data indicated while both serum A-FABP and E-FABP levels had associations with MetS, only A-FABP was significantly associated with increased risk of CAD in Chinese adults. ..
  9. Mańkowska Cyl A, Krintus M, Rajewski P, Sypniewska G. A-FABP and its association with atherogenic risk profile and insulin resistance in young overweight and obese women. Biomark Med. 2013;7:723-30 pubmed publisher
    ..6 (1.8-17.2). A-FABP seems to be a valuable predictor of atherogenic risk profile; if elevated it contributes to cardiovascular disease beyond its effect on IR. ..

More Information

Publications62

  1. Garin Shkolnik T, Rudich A, Hotamisligil G, Rubinstein M. FABP4 attenuates PPAR? and adipogenesis and is inversely correlated with PPAR? in adipose tissues. Diabetes. 2014;63:900-11 pubmed publisher
    Fatty acid binding protein 4 (FABP4, also known as aP2) is a cytoplasmic fatty acid chaperone expressed primarily in adipocytes and myeloid cells and implicated in the development of insulin resistance and atherosclerosis...
  2. Bao Y, Lu Z, Zhou M, Li H, Wang Y, Gao M, et al. Serum levels of adipocyte fatty acid-binding protein are associated with the severity of coronary artery disease in Chinese women. PLoS ONE. 2011;6:e19115 pubmed publisher
    ..135, P = 0.027). Serum A-FABP is closely associated with the presence and severity of CAD in Chinese women. ..
  3. Cabre A, Lazaro I, Cofan M, Jarauta E, Plana N, Garcia Otín A, et al. FABP4 plasma levels are increased in familial combined hyperlipidemia. J Lipid Res. 2010;51:1173-8 pubmed publisher
    ..Adipocyte fatty acid-binding protein 4 (FABP4) appears to be a determinant of atherogenic dyslipidemia...
  4. Bhushan B, Khalyfa A, Spruyt K, Kheirandish Gozal L, Capdevila O, Bhattacharjee R, et al. Fatty-acid binding protein 4 gene polymorphisms and plasma levels in children with obstructive sleep apnea. Sleep Med. 2011;12:666-71 pubmed publisher
    ..In adults with OSA, serum levels of fatty acid binding protein 4 (FABP4) are elevated and associated with the degree of metabolic insulin resistance, independent of obesity...
  5. Ortega Senovilla H, Schaefer Graf U, Meitzner K, Abou Dakn M, Graf K, Kintscher U, et al. Gestational diabetes mellitus causes changes in the concentrations of adipocyte fatty acid-binding protein and other adipocytokines in cord blood. Diabetes Care. 2011;34:2061-6 pubmed publisher
    To determine the concentrations of adipocyte fatty acid-binding protein (AFABP) and other adipocytokines in maternal and cord serum of pregnant women with gestational diabetes mellitus (GDM) and of control subjects and to relate them to ..
  6. Gorbenko O, Panayotou G, Zhyvoloup A, Volkova D, Gout I, Filonenko V. Identification of novel PTEN-binding partners: PTEN interaction with fatty acid binding protein FABP4. Mol Cell Biochem. 2010;337:299-305 pubmed publisher
    ..In particular, the interplay between PTEN function and adipocyte-specific fatty-acid-binding protein FABP4 is of notable interest...
  7. Clemente Postigo M, Queipo Ortuño M, Fernández García D, Gómez Huelgas R, Tinahones F, Cardona F. Adipose tissue gene expression of factors related to lipid processing in obesity. PLoS ONE. 2011;6:e24783 pubmed publisher
    ..acylation stimulating protein (ASP), LDL receptor-related protein 1 (LRP1) and fatty acid binding protein 4 (FABP4) gene expression was measured in VAT and SAT from 28 morbidly obese patients with Type 2 Diabetes Mellitus (T2DM) ..
  8. Toruner F, Altinova A, Akturk M, Kaya M, Arslan E, Bukan N, et al. The relationship between adipocyte fatty acid binding protein-4, retinol binding protein-4 levels and early diabetic nephropathy in patients with type 2 diabetes. Diabetes Res Clin Pract. 2011;91:203-7 pubmed publisher
    b>Adipocyte fatty acid binding protein-4 (A-FABP4) and retinol binding protein-4 (RBP4) have recently been linked to type 2 diabetes mellitus (DM)...
  9. Simon I, Escote X, Vilarrasa N, Gomez J, Fernandez Real J, Megia A, et al. Adipocyte fatty acid-binding protein as a determinant of insulin sensitivity in morbid-obese women. Obesity (Silver Spring). 2009;17:1124-8 pubmed publisher
    ..Further studies are warranted to elucidate the role of A-FABP in the pathogenesis of insulin resistance in morbid obesity. ..
  10. von Eynatten M, Breitling L, Roos M, Baumann M, Rothenbacher D, Brenner H. Circulating adipocyte fatty acid-binding protein levels and cardiovascular morbidity and mortality in patients with coronary heart disease: a 10-year prospective study. Arterioscler Thromb Vasc Biol. 2012;32:2327-35 pubmed publisher
  11. Balci M, Arslan U, Firat H, Kocaoğlu I, Vural M, Balci K, et al. Serum levels of adipocyte fatty acid-binding protein are independently associated with left ventricular mass and myocardial performance index in obstructive sleep apnea syndrome. J Investig Med. 2012;60:1020-6 pubmed publisher
    ..Further prospective studies are needed to clarify whether increased serum A-FABP level is a marker or a potential mechanism for left ventricular involvement in patients with OSAS. ..
  12. Engl J, Ciardi C, Tatarczyk T, Kaser S, Laimer M, Laimer E, et al. A-FABP--a biomarker associated with the metabolic syndrome and/or an indicator of weight change?. Obesity (Silver Spring). 2008;16:1838-42 pubmed publisher
  13. Vural B, Atalar F, Ciftci C, Demirkan A, Susleyici Duman B, Gunay D, et al. Presence of fatty-acid-binding protein 4 expression in human epicardial adipose tissue in metabolic syndrome. Cardiovasc Pathol. 2008;17:392-8 pubmed publisher
    ..Fatty-acid-binding protein 4 (FABP4/aP2), which is highly expressed in adipocytes, specifically exerts intracellular lipid trafficking...
  14. Cabre A, Valdovinos P, Lazaro I, Bonet G, Bardaji A, Masana L. Parallel evolution of circulating FABP4 and NT-proBNP in heart failure patients. Cardiovasc Diabetol. 2013;12:72 pubmed publisher
    Circulating adipocyte fatty acid-binding protein (FABP4) levels are considered to be a link between obesity, insulin resistance, diabetes, and cardiovascular (CV) diseases...
  15. Liu Q, Quinet E, Nambi P. Adipocyte fatty acid-binding protein (aP2), a newly identified LXR target gene, is induced by LXR agonists in human THP-1 cells. Mol Cell Biochem. 2007;302:203-13 pubmed
    ..In this report, we describe a novel LXR target, the adipocyte fatty acid binding protein (aP2), which plays an important role in fatty acid metabolism, adipocyte differentiation and ..
  16. Tuncman G, Erbay E, Hom X, De Vivo I, Campos H, Rimm E, et al. A genetic variant at the fatty acid-binding protein aP2 locus reduces the risk for hypertriglyceridemia, type 2 diabetes, and cardiovascular disease. Proc Natl Acad Sci U S A. 2006;103:6970-5 pubmed
    ..The fatty acid-binding protein aP2 is a cytoplasmic lipid chaperon expressed in adipocytes and macrophages...
  17. Damcott C, Moffett S, Feingold E, Barmada M, Marshall J, Hamman R, et al. Genetic variation in fatty acid-binding protein-4 and peroxisome proliferator-activated receptor gamma interactively influence insulin sensitivity and body composition in males. Metabolism. 2004;53:303-9 pubmed
    ..genes involved in lipid and glucose homeostasis, including the adipocyte-specific fatty acid-binding protein (FABP4)...
  18. Aragonès G, Saavedra P, Heras M, Cabre A, Girona J, Masana L. Fatty acid-binding protein 4 impairs the insulin-dependent nitric oxide pathway in vascular endothelial cells. Cardiovasc Diabetol. 2012;11:72 pubmed publisher
    Recent studies have shown that fatty acid-binding protein 4 (FABP4) plasma levels are associated with impaired endothelial function in type 2 diabetes (T2D)...
  19. Fuseya T, Furuhashi M, Yuda S, Muranaka A, Kawamukai M, Mita T, et al. Elevation of circulating fatty acid-binding protein 4 is independently associated with left ventricular diastolic dysfunction in a general population. Cardiovasc Diabetol. 2014;13:126 pubmed publisher
    Fatty acid-binding protein 4 (FABP4) is expressed in both adipocytes and macrophages...
  20. Kaess B, Enserro D, McManus D, Xanthakis V, Chen M, Sullivan L, et al. Cardiometabolic correlates and heritability of fetuin-A, retinol-binding protein 4, and fatty-acid binding protein 4 in the Framingham Heart Study. J Clin Endocrinol Metab. 2012;97:E1943-7 pubmed publisher
    Fetuin-A, retinol-binding protein 4 (RBP4), and fatty-acid binding protein 4 (FABP4) are novel biomarkers that may link adiposity to insulin resistance and the metabolic syndrome (MetSyn)...
  21. Kralisch S, Fasshauer M. Adipocyte fatty acid binding protein: a novel adipokine involved in the pathogenesis of metabolic and vascular disease?. Diabetologia. 2013;56:10-21 pubmed publisher
    b>Adipocyte fatty acid binding protein (AFABP, also known as aP2 and FABP4) has recently been introduced as a novel fat-derived circulating protein...
  22. Ghelfi E, Yu C, Elmasri H, Terwelp M, Lee C, Bhandari V, et al. Fatty acid binding protein 4 regulates VEGF-induced airway angiogenesis and inflammation in a transgenic mouse model: implications for asthma. Am J Pathol. 2013;182:1425-33 pubmed publisher
    ..Fatty acid binding protein 4 (FABP4 or aP2) is an intracellular lipid chaperone that is induced by VEGF in endothelial cells...
  23. Chow W, Tso A, Xu A, Yuen M, Fong C, Lam T, et al. Elevated circulating adipocyte-fatty acid binding protein levels predict incident cardiovascular events in a community-based cohort: a 12-year prospective study. J Am Heart Assoc. 2013;2:e004176 pubmed publisher
    ..017). Circulating A-FABP level predicts the development of CVD after adjustment for traditional risk factors in a community-based cohort. Its clinical use for CVD prediction warrants further validation. ..
  24. Doi M, Miyoshi T, Hirohata S, Nakamura K, Usui S, Takeda K, et al. Association of increased plasma adipocyte fatty acid-binding protein with coronary artery disease in non-elderly men. Cardiovasc Diabetol. 2011;10:44 pubmed publisher
    ..06, 95% confidence interval: 1.34 to 6.98, p < 0.01), but not in subjects aged ?65 years. Increased plasma A-FABP in non-elderly men had a significant association with the presence of CAD, independent of established CAD risk factors. ..
  25. Tso A, Lam T, Xu A, Yiu K, Tse H, Li L, et al. Serum adipocyte fatty acid-binding protein associated with ischemic stroke and early death. Neurology. 2011;76:1968-75 pubmed publisher
    ..18-5.96, p=0.018), independent of age and NIH Stroke Scale score. Serum A-FABP was significantly associated with ischemic stroke in our case-control study, and may serve as a useful prognostic indicator for early mortality. ..
  26. Fasshauer M, Seeger J, Waldeyer T, Schrey S, Ebert T, Kratzsch J, et al. Serum levels of the adipokine adipocyte fatty acid-binding protein are increased in preeclampsia. Am J Hypertens. 2008;21:582-6 pubmed publisher
    ..Recently, adipocyte fatty acid-binding protein (AFABP) was introduced as a novel adipokine, serum levels of which independently correlate with the development of the ..
  27. Miyoshi T, Doi M, Hirohata S, Kamikawa S, Usui S, Ogawa H, et al. Olmesartan reduces arterial stiffness and serum adipocyte fatty acid-binding protein in hypertensive patients. Heart Vessels. 2011;26:408-13 pubmed publisher
    b>Adipocyte fatty acid binding protein (A-FABP) has been reported to be involved in insulin resistance, lipid metabolism, and atherosclerosis; however, little is known about the effect of medication on the change in circulating A-FABP in ..
  28. Cabre A, Lazaro I, Girona J, Manzanares J, Marimón F, Plana N, et al. Plasma fatty acid binding protein 4 is associated with atherogenic dyslipidemia in diabetes. J Lipid Res. 2008;49:1746-51 pubmed publisher
    The aim of this study was to evaluate the impact of adipocyte fatty acid binding protein 4 (FABP4) on the lipid profile in type 2 diabetic subjects...
  29. Cabre A, Lazaro I, Girona J, Manzanares J, Marimón F, Plana N, et al. Plasma fatty acid-binding protein 4 increases with renal dysfunction in type 2 diabetic patients without microalbuminuria. Clin Chem. 2008;54:181-7 pubmed
    Fatty acid-binding protein 4 (FABP4) has been linked to metabolic syndrome development, diabetes, and arteriosclerosis, but the role of FABP4 in target organ damage has not been assessed...
  30. Miyoshi T, Onoue G, Hirohata A, Hirohata S, Usui S, Hina K, et al. Serum adipocyte fatty acid-binding protein is independently associated with coronary atherosclerotic burden measured by intravascular ultrasound. Atherosclerosis. 2010;211:164-9 pubmed publisher
    ..Increased serum A-FABP was significantly associated with a greater coronary plaque burden. Our findings revealed that the measurement of serum A-FABP could be utilized for the evaluation of the extent of coronary atherosclerosis. ..
  31. Hsu B, Chen Y, Lee R, Lee C, Lee C, Wang J. Fasting serum level of fatty-acid-binding protein 4 positively correlates with metabolic syndrome in patients with coronary artery disease. Circ J. 2010;74:327-31 pubmed
    The serum level of fatty-acid-binding protein 4 (FABP4) increases in patients with metabolic syndrome (MetS), so the relationship between FABP4 and MetS among patients with coronary artery disease (CAD) was investigated in the present ..
  32. Wang J, Tang J, Wang B, Song J, Liu J, Wei Z, et al. FABP4: a novel candidate gene for polycystic ovary syndrome. Endocrine. 2009;36:392-6 pubmed publisher
    ..Adipocyte-fatty acid-binding protein (FABP4) is an adipokine regulating systemic insulin sensitivity, lipid and glucose metabolism...
  33. Rhee E, Lee W, Park C, Oh K, Kim B, Sung K, et al. The association of serum adipocyte fatty acid-binding protein with coronary artery disease in Korean adults. Eur J Endocrinol. 2009;160:165-72 pubmed publisher
    Adipocyte fatty acid-binding protein (A-FABP), also known as aP2 or FABP4, is abundantly expressed in adipocytes and plays a role in glucose homeostasis...
  34. Hancke K, Grubeck D, Hauser N, Kreienberg R, Weiss J. Adipocyte fatty acid-binding protein as a novel prognostic factor in obese breast cancer patients. Breast Cancer Res Treat. 2010;119:367-7 pubmed publisher
    ..05) and nodal-status (P\0.05).Our study reveals that high A-FABP serum levels are associated with obesity, breast cancer risk, and adverse tumor characteristics. ..
  35. Elmasri H, Karaaslan C, Teper Y, Ghelfi E, Weng M, Ince T, et al. Fatty acid binding protein 4 is a target of VEGF and a regulator of cell proliferation in endothelial cells. FASEB J. 2009;23:3865-73 pubmed publisher
    Fatty acid binding protein 4 (FABP4) plays an important role in maintaining glucose and lipid homeostasis...
  36. Lamounier Zepter V, Look C, Alvarez J, Christ T, Ravens U, Schunck W, et al. Adipocyte fatty acid-binding protein suppresses cardiomyocyte contraction: a new link between obesity and heart disease. Circ Res. 2009;105:326-34 pubmed publisher
    Adipocyte fatty acid-binding protein (FABP4) is a member of the intracellular lipid-binding protein family and is predominantly expressed in adipose tissue...
  37. Ordovas J. Identification of a functional polymorphism at the adipose fatty acid binding protein gene (FABP4) and demonstration of its association with cardiovascular disease: a path to follow. Nutr Rev. 2007;65:130-4 pubmed
    ..So far, nine tissue-specific cytoplasmic FABPs have been identified. Adipose tissue FABP (FABP4) has been suggested to be a bridge between inflammation and other pathways related to the metabolic syndrome...
  38. Lu L, Wang Y, Sun W, Liu Z, Zhang Q, Pu L, et al. Two-dimensional fluorescence in-gel electrophoresis of coronary restenosis tissues in minipigs: increased adipocyte fatty acid binding protein induces reactive oxygen species-mediated growth and migration in smooth muscle cells. Arterioscler Thromb Vasc Biol. 2013;33:572-80 pubmed publisher
    ..2D-DIGE), and to investigate the influences of crucial proteins identified, particularly adipocyte fatty acid binding protein (AFABP), in human arterial smooth muscle cells...
  39. Cabre A, Lazaro I, Girona J, Manzanares J, Marimón F, Plana N, et al. Fatty acid binding protein 4 is increased in metabolic syndrome and with thiazolidinedione treatment in diabetic patients. Atherosclerosis. 2007;195:e150-8 pubmed
    To study the role of FABP4 in the plasma of type 2 diabetic (T2D) subjects with and without metabolic syndrome (MS) and the impact of thiazolidinedione (TZD) treatment...
  40. Fu Y, Luo N, Lopes Virella M, Garvey W. The adipocyte lipid binding protein (ALBP/aP2) gene facilitates foam cell formation in human THP-1 macrophages. Atherosclerosis. 2002;165:259-69 pubmed
    ..From this analysis, we have identified adipocyte lipid binding protein (ALBP/aP2) as a gene that is highly upregulated in foam cells in response to oxLDL...
  41. Huang C, Wu Y, Wu C, Lin L, Wu Y, Hsu P, et al. Association between serum adipocyte fatty-acid binding protein concentrations, left ventricular function and myocardial perfusion abnormalities in patients with coronary artery disease. Cardiovasc Diabetol. 2013;12:105 pubmed publisher
    ..71, 95% CI, 1.23-5.94; P = 0.013). Serum A-FABP levels not only were associated with myocardial perfusion abnormalities and left ventricular function, but also predicted the presence of heart failure in our patients with CAD. ..
  42. Fischer H, Gustafsson T, Sundberg C, Norrbom J, Ekman M, Johansson O, et al. Fatty acid binding protein 4 in human skeletal muscle. Biochem Biophys Res Commun. 2006;346:125-30 pubmed
    ..In the present study, our aims were to investigate if FABP4 is expressed within skeletal muscle fibers and if FABP3 and FABP4 are more abundant in skeletal muscle fibers in ..
  43. Fu Y, Luo L, Luo N, Garvey W. Lipid metabolism mediated by adipocyte lipid binding protein (ALBP/aP2) gene expression in human THP-1 macrophages. Atherosclerosis. 2006;188:102-11 pubmed
    ..We previously reported that adipocyte lipid binding protein (ALBP/aP2) is a gene that is highly up-regulated in foam cells in response to oxLDL...
  44. Agardh H, Folkersen L, Ekstrand J, Marcus D, Swedenborg J, Hedin U, et al. Expression of fatty acid-binding protein 4/aP2 is correlated with plaque instability in carotid atherosclerosis. J Intern Med. 2011;269:200-10 pubmed publisher
    ..profiling (n = 40) and quantitative RT-PCR (n = 105) revealed increased levels of fatty acid-binding protein 4 (FABP4/aP2) in lesions from patients with recent symptoms of plaque instability compared to asymptomatic patients (array: ..
  45. Liu M, Zhou M, Bao Y, Xu Z, Li H, Zhang H, et al. Circulating adipocyte fatty acid-binding protein levels are independently associated with heart failure. Clin Sci (Lond). 2013;124:115-22 pubmed
    ..49-19.30); P<0.001]. Our results demonstrate that A-FABP is closely associated with HF, and raise the possibility that increased A-FABP may be causally related to the pathogenesis of heart dysfunction in humans. ..
  46. Koh J, Shin Y, Nam S, Lee M, Chung C, Shin J. Serum adipocyte fatty acid-binding protein levels are associated with nonalcoholic fatty liver disease in type 2 diabetic patients. Diabetes Care. 2009;32:147-52 pubmed publisher
    ..Our study demonstrates that serum A-FABP is significantly associated with NAFLD in type 2 diabetes, independent of BMI, waist circumference, HOMA-IR, A1C, triglycerides, HDL cholesterol, and CRP. ..
  47. Yeung D, Xu A, Tso A, Chow W, Wat N, Fong C, et al. Circulating levels of adipocyte and epidermal fatty acid-binding proteins in relation to nephropathy staging and macrovascular complications in type 2 diabetic patients. Diabetes Care. 2009;32:132-4 pubmed publisher
    ..92 [95% CI 1.42-6.01]; P = 0.004). Serum A-FABP and E-FABP might be novel serum biomarkers for evaluating the progression of nephropathy and its cardiovascular risk in type 2 diabetic patients. ..
  48. Yun K, Kim S, Choi K, Park H. Association between adipocyte fatty acid-binding protein levels and childhood obesity in Korean children. Metabolism. 2009;58:798-802 pubmed publisher
  49. Furuhashi M, Ishimura S, Ota H, Hayashi M, Nishitani T, Tanaka M, et al. Serum fatty acid-binding protein 4 is a predictor of cardiovascular events in end-stage renal disease. PLoS ONE. 2011;6:e27356 pubmed publisher
    Fatty acid-binding protein 4 (FABP4/A-FABP/aP2), a lipid chaperone, is expressed in both adipocytes and macrophages...
  50. Kim Y, Cho Y, Lee W, Kim H, Park J, Park D, et al. Serum adipocyte-specific fatty acid-binding protein is associated with nonalcoholic fatty liver disease in apparently healthy subjects. J Nutr Biochem. 2011;22:289-92 pubmed publisher
    ..11-7.35, P<.05) after further adjustment for all metabolic parameters including TNF-?. The serum level of A-FABP was independently associated with NAFLD and showed significant correlation with TNF-?, HOMA-IR, and metabolic syndrome. ..
  51. Aragonès G, Ferre R, Lazaro I, Cabre A, Plana N, Merino J, et al. Fatty acid-binding protein 4 is associated with endothelial dysfunction in patients with type 2 diabetes. Atherosclerosis. 2010;213:329-31 pubmed publisher
    Adipocyte fatty acid-binding protein (FABP4) plasma levels are higher in type 2 diabetes (T2D). Endothelial dysfunction is also common in T2D...
  52. Corripio R, González Clemente J, Pérez Sánchez J, Näf S, Gallart L, Nosàs R, et al. Weight loss in prepubertal obese children is associated with a decrease in adipocyte fatty-acid-binding protein without changes in lipocalin-2: a 2-year longitudinal study. Eur J Endocrinol. 2010;163:887-93 pubmed publisher
    Lipocalin-2 and adipocyte fatty-acid-binding protein (A-FABP or FABP4) are adipokines potentially involved in the pathophysiology of obesity and metabolic syndrome in adults. In children, they have been scarcely studied...
  53. Terra X, Quintero Y, Auguet T, Porras J, Hernández M, Sabench F, et al. FABP 4 is associated with inflammatory markers and metabolic syndrome in morbidly obese women. Eur J Endocrinol. 2011;164:539-47 pubmed publisher
    The adipocyte/macrophage fatty acid-binding protein 4 (FABP4) has been described as a biomarker for adiposity and metabolic syndrome (MS)...