F9

Summary

Gene Symbol: F9
Description: coagulation factor IX
Alias: F9 p22, FIX, HEMB, P19, PTC, THPH8, coagulation factor IX, Christmas factor, factor 9, factor IX F9, plasma thromboplastic component, plasma thromboplastin component
Species: human
Products:     F9

Top Publications

  1. Yoshitake S, Schach B, Foster D, Davie E, Kurachi K. Nucleotide sequence of the gene for human factor IX (antihemophilic factor B). Biochemistry. 1985;24:3736-50 pubmed
    Two different human genomic DNA libraries were screened for the gene for blood coagulation factor IX by employing a cDNA for the human protein as a hybridization probe...
  2. Kurachi S, Huo J, Ameri A, Zhang K, Yoshizawa A, Kurachi K. An age-related homeostasis mechanism is essential for spontaneous amelioration of hemophilia B Leyden. Proc Natl Acad Sci U S A. 2009;106:7921-6 pubmed publisher
    ..This study demonstrates the clinical relevance of the first discovered puberty-onset gene switch, the ASE/AIE-mediated regulatory mechanism. ..
  3. Romero I, Conde N, García Aldana D, Ruano A, Fernández Teijeiro A. [Review of patients studied for coagulopathy in a Hematology/Oncology unit]. An Pediatr (Barc). 2016;84:85-91 pubmed publisher
    ..The reason for referral should be based more on clinical bleeding and not just on an abnormal coagulation time. The most frequent diagnoses were type 1 von Willebrand disease and factor xii deficiency. ..
  4. Kristensen L, Olsen O, Blouse G, Brandstetter H. Releasing the brakes in coagulation Factor IXa by co-operative maturation of the substrate-binding site. Biochem J. 2016;473:2395-411 pubmed publisher
    b>Coagulation Factor IX is positioned at the merging point of the intrinsic and extrinsic blood coagulation cascades...
  5. Omura K, Tsuchiya S. The Patient Experience of Hemophilia and Human Immunodeficiency Virus: A Systematic Review of Qualitative Evidence. JBI Libr Syst Rev. 2012;10:4659-4668 pubmed
    ..Furthermore, there are few studies of hemophilia patients as hemophilia is a rare disease. Thus, synthesis of qualitative evidence is critical to understand patient values. ..
  6. Barzel A, Paulk N, Shi Y, Huang Y, Chu K, Zhang F, et al. Promoterless gene targeting without nucleases ameliorates haemophilia B in mice. Nature. 2015;517:360-4 pubmed publisher
    ..In particular, we target a promoterless human coagulation factor IX (F9) gene to the liver-expressed mouse albumin (Alb) locus...
  7. Mutlu P, Ural A, Gündüz U. Different types of cell cycle- and apoptosis-related gene expressions alter in corticosteroid-, vincristine-, and melphalan-resistant u-266 multiple myeloma cell lines. Turk J Haematol. 2014;31:231-8 pubmed publisher
    ..The fetus of the proband's cousin was identified as a carrier. Our identification of a novel mutation in the F9 gene associated with hemophilia B provides novel insight into the pathogenesis of this genetically inherited ..
  8. O Brien K, Lozier J, Cullinane A, Osorio B, Nghiem K, Speransky V, et al. Identification of a novel mutation in HPS6 in a patient with hemophilia B and oculocutaneous albinism. Mol Genet Metab. 2016;119:284-287 pubmed publisher
    ..His factor IX level was markedly reduced at 13%; whole exome and Sanger sequencing showed the Durham mutation in F9 (NM_000133.3)...
  9. Wang Y, Zhao J, Duan N, Liu W, Zhang Y, Zhou M, et al. Paired CRISPR/Cas9 Nickases Mediate Efficient Site-Specific Integration of F9 into rDNA Locus of Mouse ESCs. Int J Mol Sci. 2018;19: pubmed publisher
    ..Importantly, the differentiated cells could transcribe exogenous F9 and secrete coagulation factor IX (FIX) proteins, suggesting active transcription and stable inheritance of transgenes in the rDNA locus...

More Information

Publications154 found, 100 shown here

  1. Sternebring O, Christensen J, Bjørnsdottir I. Pharmacokinetics, tissue distribution, excretion, and metabolite profiling of PEGylated rFIX (nonacog beta pegol, N9-GP) in rats. Eur J Pharm Sci. 2016;92:163-72 pubmed publisher
    ..conjugated with a 40-kDa branched polyethylene glycol (PEG) to extend plasma half-life (t½) compared with native FIX, developed for the treatment of haemophilia B...
  2. Wang L, Yang Y, Breton C, White J, Zhang J, Che Y, et al. CRISPR/Cas9-mediated in vivo gene targeting corrects hemostasis in newborn and adult factor IX knockout mice. Blood. 2019;: pubmed publisher
    ..We developed a donor vector containing a promoter-less, partial human factor IX (FIX) cDNA carrying the hyperactive FIX Padua mutation...
  3. Wang X, Su J, Sherman A, Rogers G, Liao G, Hoffman B, et al. Plant-based oral tolerance to hemophilia therapy employs a complex immune regulatory response including LAP+CD4+ T cells. Blood. 2015;125:2418-27 pubmed publisher
    ..plants suppressed inhibitor formation directed against factors VIII and IX and anaphylaxis against factor IX (FIX)...
  4. Brenig B, Steingräber L, Shan S, Xu F, Hirschfeld M, Andag R, et al. Christmas disease in a Hovawart family resembling human hemophilia B Leyden is caused by a single nucleotide deletion in a highly conserved transcription factor binding site of the F9 gene promoter. Haematologica. 2019;: pubmed publisher
    ..monogenic X-chromosomal recessively transmitted bleeding disorder caused by genetic variants within the coagulation factor IX gene. Although hemophilia B has been described in dogs, it has not yet been reported in the Hovawart...
  5. O Brien B, Mason J, Kimble R. Bleeding Disorders in Adolescents with Heavy Menstrual Bleeding: The Queensland Statewide Paediatric and Adolescent Gynaecology Service. J Pediatr Adolesc Gynecol. 2019;32:122-127 pubmed publisher
    ..Adolescents with HMB who present to a tertiary pediatric and adolescent gynecology service should be screened for bleeding disorders, because of the considerably high prevalence in this at-risk population. ..
  6. Plautz W, Chattopadhyay R, Goldfeld E, Samelson Jones B, Pilli V, Campello E, et al. Padua FIXa resistance to Protein S and a potential therapy for hyperactive FIXa. Thromb Res. 2018;170:133-141 pubmed publisher
    Abnormalities in the levels and functions of proteins that maintain hemostasis can cause thrombosis. Factor IX (FIX) R338L, i.e., Factor IX Padua, is a hyperactive clotting factor that promotes thrombosis...
  7. Derosa F, Guild B, Karve S, Smith L, Love K, Dorkin J, et al. Therapeutic efficacy in a hemophilia B model using a biosynthetic mRNA liver depot system. Gene Ther. 2016;23:699-707 pubmed publisher
    ..Exemplifying the possible broad utility of mRNA drugs, therapeutically relevant amounts of human FIX (hFIX) protein were achieved upon a single intravenous dose of hFIX mRNA-loaded lipid nanoparticles in mice...
  8. Ohmori T, Nagao Y, Mizukami H, Sakata A, Muramatsu S, Ozawa K, et al. CRISPR/Cas9-mediated genome editing via postnatal administration of AAV vector cures haemophilia B mice. Sci Rep. 2017;7:4159 pubmed publisher
    Haemophilia B, a congenital haemorrhagic disease caused by mutations in coagulation factor IX gene (F9), is considered an appropriate target for genome editing technology...
  9. Rasmussen C, Nowak J, Larsen J, Bottomley A, Rowles A, Offenberg H. Evaluation of Nonacog Beta Pegol Long-term Safety in the Immune-deficient Rowett Nude Rat (Crl:NIH-Foxn1rnu). Toxicol Pathol. 2016;44:726-37 pubmed publisher
    Nonacog beta pegol is a 40-kDa polyethylene glycosylated (PEGylated) human recombinant coagulation factor IX, intended for the treatment of hemophilia B...
  10. Su J, Zhu L, Sherman A, Wang X, Lin S, Kamesh A, et al. Low cost industrial production of coagulation factor IX bioencapsulated in lettuce cells for oral tolerance induction in hemophilia B. Biomaterials. 2015;70:84-93 pubmed publisher
    Antibodies (inhibitors) developed by hemophilia B patients against coagulation factor IX (FIX) are challenging to eliminate because of anaphylaxis or nephrotic syndrome after continued infusion...
  11. Cao D, Liu X, Mu K, Ma X, Sun J, Bai X, et al. Identification and Genetic Analysis of a Factor IX Gene Intron 3 Mutation in a Hemophilia B Pedigree in China. Turk J Haematol. 2014;31:226-30 pubmed publisher
    ..The fetus of the proband's cousin was identified as a carrier. Our identification of a novel mutation in the F9 gene associated with hemophilia B provides novel insight into the pathogenesis of this genetically inherited ..
  12. Lu W, Zhou Q, Yang H, Wang H, Gu Y, Shen Q, et al. Gene therapy for hemophilia B mice with scAAV8-LP1-hFIX. Front Med. 2016;10:212-8 pubmed publisher
    Hemophilia B is a hemorrhagic disease caused by the deficiency of clotting factor IX (FIX). Gene therapy might be the ultimate strategy for the disease...
  13. Li S, Luo Y, Zhang L, Yang W, Zhang G. Targeted introduction and effective expression of hFIX at the AAVS1 locus in mesenchymal stem cells. Mol Med Rep. 2017;15:1313-1318 pubmed publisher
  14. Sack B, Wang X, Sherman A, Rogers G, Markusic D. Immune responses to human factor IX in haemophilia B mice of different genetic backgrounds are distinct and modified by TLR4. Haemophilia. 2015;21:133-9 pubmed publisher
    Our laboratory develops protocols to prevent or reverse ongoing anti-hFIX IgG inhibitors in haemophilia B mice with a F9 gene deletion on BALB/c and C3H/HeJ backgrounds...
  15. Markusic D, Nichols T, Merricks E, Palaschak B, Zolotukhin I, Marsic D, et al. Evaluation of engineered AAV capsids for hepatic factor IX gene transfer in murine and canine models. J Transl Med. 2017;15:94 pubmed publisher
    ..We tested several engineered AAV capsids for factor IX (FIX) expression for the treatment of hemophilia B by hepatic gene transfer...
  16. Huai C, Jia C, Sun R, Xu P, Min T, Wang Q, et al. CRISPR/Cas9-mediated somatic and germline gene correction to restore hemostasis in hemophilia B mice. Hum Genet. 2017;136:875-883 pubmed publisher
    Hemophilia B (HB) is an X-linked disorder caused by defects of F9 encoded coagulation factor IX, which is an ideal model for gene therapy...
  17. Anderson C, Moisyadi S, Avelar A, Walton C, Shohet R. Ultrasound-targeted hepatic delivery of factor IX in hemophiliac mice. Gene Ther. 2016;23:510-9 pubmed publisher
    ..delivery of plasmid and transposase-based vectors encoding human factor IX (hFIX) to the livers of hemophilia B (FIX-/-) mice...
  18. Dumont J, Loveday K, Light D, Pierce G, Jiang H. Evaluation of the toxicology, pharmacokinetics, and local tolerance of recombinant factor IX Fc fusion protein in animals. Thromb Res. 2015;136:371-8 pubmed publisher
    ..rFIXFc was well tolerated in toxicology studies and demonstrated a low thrombogenic potential. These results are consistent with phase 1/2a and phase 3 clinical studies of rFIXFc in people with hemophilia B. ..
  19. Ankrom W, Wood H, Xu J, Geissler W, Bateman T, Chatterjee M, et al. Preclinical and translational evaluation of coagulation factor IXa as a novel therapeutic target. Pharmacol Res Perspect. 2016;4:e00207 pubmed publisher
    The benefits of novel oral anticoagulants are hampered by bleeding. Since coagulation factor IX (fIX) lies upstream of fX in the coagulation cascade, and intermediate levels have been associated with reduced incidence of thrombotic ..
  20. Sun J, Hua B, Livingston E, Taves S, Johansen P, Hoffman M, et al. Abnormal joint and bone wound healing in hemophilia mice is improved by extending factor IX activity after hemarthrosis. Blood. 2017;129:2161-2171 pubmed publisher
    ..We observed healing following induced joint hemorrhage in WT and factor IX (FIX) knockout (FIX-/-) mice, examining also parameters previously studied in an excisional skin wound model...
  21. Lyu C, Shen J, Wang R, Gu H, Zhang J, Xue F, et al. Targeted genome engineering in human induced pluripotent stem cells from patients with hemophilia B using the CRISPR-Cas9 system. Stem Cell Res Ther. 2018;9:92 pubmed publisher
    ..The AAVS1-Cas9-sgRNA plasmid which targets the AAVS1 locus and the AAVS1-EF1α-F9 cDNA-puromycin donor plasmid were constructed, and they were electroporated into the iPSCs...
  22. Guan Y, Ma Y, Li Q, Sun Z, Ma L, Wu L, et al. CRISPR/Cas9-mediated somatic correction of a novel coagulator factor IX gene mutation ameliorates hemophilia in mouse. EMBO Mol Med. 2016;8:477-88 pubmed publisher
    ..Here, we identify a family with hemophilia B carrying a novel mutation, Y371D, in the human F9 gene...
  23. Khandagale A, Kittner J, Mann A, Ascher S, Kollar B, Reinhardt C. Coagulation factor 9-deficient mice are protected against dextran sulfate sodium-induced colitis. Biol Open. 2018;7: pubmed publisher
    ..Remarkably, we identified expression of coagulation factor IX (FIX) protein in small intestinal epithelial cells (MODE-K)...
  24. Metzger J, Tadin Strapps M, Thankappan A, Strapps W, DiPietro M, Leander K, et al. Titrating haemophilia B phenotypes using siRNA strategy: evidence that antithrombotic activity is separated from bleeding liability. Thromb Haemost. 2015;113:1300-11 pubmed publisher
    ..silencing combined with a gene knockout (KO) approach was used to define the relative contribution of factor IX (fIX) to thrombosis and primary haemostasis in the rat...
  25. Ono K, Hirose J, Chang S, Kubota M, Kinkawa J, Noguchi M, et al. Orthotropic live transplantation for cirrhosis from hepatitis C virus leads to correction of factor IX deficiency allowing for ankle arthroplasty without factor replacement in a patient with moderate haemophilia B. Blood Coagul Fibrinolysis. 2017;: pubmed publisher
    ..We carefully monitored the patient's factor IX (FIX) plasma levels during his perioperative period, and we successfully performed his arthroscopic ankle arthrodesis ..
  26. Caviglia H, Landro M, Galatro G, Candela M, Neme D. Epidemiology of fractures in patients with haemophilia. Injury. 2015;46:1885-90 pubmed publisher
    ..We believe that the advent of new and accessibly treatments, decreased the development of orthopaedic complications and favours the improvement in quality of life of PWH. ..
  27. Chia J, Louber J, Glauser I, Taylor S, Bass G, Dower S, et al. Half-life-extended recombinant coagulation factor IX-albumin fusion protein is recycled via the FcRn-mediated pathway. J Biol Chem. 2018;293:6363-6373 pubmed publisher
    ..Recently, a long-acting recombinant coagulation factor IX-albumin fusion protein (rIX-FP) has been approved for the management of hemophilia B...
  28. Holstein K, Schneppenheim R, Schrum J, Bokemeyer C, Langer F. Successful second ITI with factor IX and combined immunosuppressive therapy. A patient with severe haemophilia B and recurrence of a factor IX inhibitor. Hamostaseologie. 2014;34 Suppl 1:S5-8 pubmed publisher
    ..50-90%). According to case reports, immunosuppressive therapy in addition to high doses of factor IX (FIX) appears to be promising...
  29. Lai X, Zhang B, Jiang Y, Li J, Zhao R, Yang X, et al. High Risk of Lateral Nodal Metastasis in Lateral Solitary Solid Papillary Thyroid Cancer. Ultrasound Med Biol. 2016;42:75-81 pubmed publisher
    ..ultrasonic intra-thyroidal location and neck node metastasis pattern in solitary solid papillary thyroid cancer (PTC). Data on 186 patients were retrospectively reviewed...
  30. Martinez Camblor P, Pardo Fernández J. Parametric estimates for the receiver operating characteristic curve generalization for non-monotone relationships. Stat Methods Med Res. 2017;:962280217747009 pubmed publisher
    ..When the diagnostic procedure is based on a continuous marker, this is equivalent to fix a region or classification subset and then check if the observed value of the marker belongs to that region...
  31. Ulrich S, Brand B, Speich R, Oldenburg J, Asmis L. Congenital hypersensitivity to vitamin K antagonists due to FIX propeptide mutation at locus -10: a (not so) rare cause of bleeding under oral anticoagulant therapy in Switzerland. Swiss Med Wkly. 2008;138:100-7 pubmed publisher
    ..It occurs in patients with FIX propeptide mutations at locus -10...
  32. Sung T, Kim M, Kim T, Kim W, Park Y, Song D, et al. Negative Expression of CPSF2 Predicts a Poorer Clinical Outcome in Patients with Papillary Thyroid Carcinoma. Thyroid. 2015;25:1020-5 pubmed publisher
    The BRAF(V600E) mutation is a promising prognostic biomarker for patients with papillary thyroid carcinoma (PTC), but its prevalence differs widely among different geographic regions...
  33. Wang X, Wang M, Zhang Y, Miao X, Huang Y, Zhang J, et al. Electrochemical biosensor based on enzyme substrate as a linker: Application for aldolase activity with pectin-thionine complex as recognization element and signal amplification probe. Biosens Bioelectron. 2016;83:91-6 pubmed publisher
    ..thereby an electrochemical method to detect aldolase activity is established using pectin-thionine complex (PTC) as recognization element and signal probe...
  34. Xu J, Hardin H, Zhang R, Sundling K, Buehler D, Lloyd R. Stage-Specific Embryonic Antigen-1 (SSEA-1) Expression in Thyroid Tissues. Endocr Pathol. 2016;27:271-275 pubmed
    ..Anaplastic thyroid (ATC) (80 %) and conventional papillary thyroid carcinoma (PTC) (60...
  35. Yan Y, Meng Z, Hao S, Wang F, Jin X, Sun D, et al. Five Novel COL7A1 Gene Mutations in Three Chinese Patients with Recessive Dystrophic Epidermolysis Bullosa. Ann Clin Lab Sci. 2018;48:100-105 pubmed
    ..8038G>A in exon 108). The first three novel mutations resulted in a premature termination codon (PTC), the remaining two novel mutations caused a glycine substitution and a loss of the primary ATG start codon, ..
  36. Kauffmann R, Hamner J, Ituarte P, Yim J. Age greater than 60 years portends a worse prognosis in patients with papillary thyroid cancer: should there be three age categories for staging?. BMC Cancer. 2018;18:316 pubmed publisher
    Age is an important prognostic factor in papillary thyroid cancer (PTC), with better survival observed in patients < 45 years of age, regardless of stage...
  37. Traub Weidinger T, Putzer D, von Guggenberg E, Dobrozemsky G, Nilica B, Kendler D, et al. Multiparametric PET imaging in thyroid malignancy characterizing tumour heterogeneity: somatostatin receptors and glucose metabolism. Eur J Nucl Med Mol Imaging. 2015;42:1995-2001 pubmed publisher
    ..These 31 patients comprised 18 with radioiodine non-avid differentiated TC (DTC) including 6 papillary TC (PTC), 8 follicular TC (FTC) and 4 oxyphilic TC (oxyTC), 5 with anaplastic TC (ATC), and 8 with medullary TC (MTC)...
  38. Korotkov S, Konovalova S, Brailovskaya I, Saris N. To involvement the conformation of the adenine nucleotide translocase in opening the Tl(+)-induced permeability transition pore in Ca(2+)-loaded rat liver mitochondria. Toxicol In Vitro. 2016;32:320-32 pubmed publisher
    ..were markedly inhibited by ADP and membrane-penetrant hydrophobic thiol reagent, N-ethylmaleimide (NEM) which fix the ANT in 'm' conformation. Cyclosporine A additionally potentiated these effects of ADP and NEM...
  39. Kim S, Woo J, Lee J, Park I, Choe J, Kim J, et al. Prophylactic Central Neck Dissection Might Not Be Necessary in Papillary Thyroid Carcinoma: Analysis of 11,569 Cases from a Single Institution. J Am Coll Surg. 2016;222:853-64 pubmed publisher
    ..central neck dissection (pCND) remain controversial in clinically node-negative (cN0) papillary thyroid carcinoma (PTC). The purpose of this study was to investigate the clinical impact of pCND with a large group of cN0 PTC patients...
  40. Pires R, Giordano V, Wajnsztejn A, Oliveira Santana E, Pesantez R, Lee M, et al. Complications and outcomes of the transfibular approach for posterolateral fractures of the tibial plateau. Injury. 2016;47:2320-2325 pubmed publisher
    ..The surgeon must gently protect the peroneal nerve during the entire procedure and fix the osteotomy with long screws to prevent loss of reduction. Therapeutic level IV.
  41. Rasmussen R, Erstad S, Ramos Martinez E, Fimognari L, de Porcellinis A, Sakuragi Y. An easy and efficient permeabilization protocol for in vivo enzyme activity assays in cyanobacteria. Microb Cell Fact. 2016;15:186 pubmed
    ..The abilities of cyanobacteria to fix atmospheric CO2 and to allocate the fixed carbons to chemicals and biofuels have attracted growing ..
  42. Shen C, Wei W, Qiu Z, Song H, Zhang X, Sun Z, et al. Metformin reduces glycometabolism of papillary thyroid carcinoma in vitro and in vivo. J Mol Endocrinol. 2017;58:15-23 pubmed
    ..Human papillary thyroid carcinoma (PTC) cell lines BCPAP and KTC1 were used. Cell viability was detected by CCK8 assay...
  43. Li J, Wang C, Fu H, Cui J, Xu P, Guo J, et al. High-performance adsorption and separation of anionic dyes in water using a chemically stable graphene-like metal-organic framework. Dalton Trans. 2017;46:10197-10201 pubmed publisher
    ..7 mg g-1 at room temperature. It was used to fix a SPE column to conduct rapid separation of anionic dyes from an organic dye matrix...
  44. Wu Z, Cao Y, Jiang X, Li M, Wang G, Yang Y, et al. Clinicopathological significance of chemokine receptor CXCR4 expression in papillary thyroid carcinoma: a meta-analysis. Minerva Endocrinol. 2018;: pubmed publisher
    ..type 4(CXCR 4) is a candidate oncogene in several types of human tumors including papillary thyroid carcinoma (PTC). To investigate its expression impact on clinicopathological features, a meta-analysis was performed...
  45. Miller J, Chan C, Pearce D. The role of nonsense-mediated decay in neuronal ceroid lipofuscinosis. Hum Mol Genet. 2013;22:2723-34 pubmed publisher
    ..We contend that NMD targets PTCs in NCL gene transcripts for degradation. A number of PTC mutations in CLN1, CLN2 and CLN3 lead to a significant decrease in mRNA transcripts and a corresponding decrease in ..
  46. Shah P, McCandlish D, Plotkin J. Contingency and entrenchment in protein evolution under purifying selection. Proc Natl Acad Sci U S A. 2015;112:E3226-35 pubmed publisher
    ..though the predicted effects on stability of random mutations are almost completely additive, the mutations that fix under purifying selection are enriched for epistasis...
  47. Ushenkova L, Koterov A, Biryukov A. [RET/PTC Gene Rearrangements in the Sporadic and Radiogenic Thyroid Tumors: Molecular Genetics, Radiobiology and Molecular Epidemiology]. Radiats Biol Radioecol. 2015;55:229-49 pubmed
    ..of molecular genetic, radiobiological and molecular epidemiological studies of gene (chromosome) rearrangements RET/PTC in the cells of the thyroid gland as well as the laws in relation to radiation exposure in vitro, in vivo and human ..
  48. Yuen J, Pluthero F, Douda D, Riedl M, Cherry A, Ulanova M, et al. NETosing Neutrophils Activate Complement Both on Their Own NETs and Bacteria via Alternative and Non-alternative Pathways. Front Immunol. 2016;7:137 pubmed publisher
    ..aeruginosa, whereas additional components present in the serum help to fix non-AP-mediated complement both on NETs and bacteria...
  49. Ott C, Vinberg M, Kessing L, Miskowiak K. The effect of erythropoietin on cognition in affective disorders - Associations with baseline deficits and change in subjective cognitive complaints. Eur Neuropsychopharmacol. 2016;26:1264-73 pubmed publisher
    ..baseline cognitive impairment increased the odds of treatment-efficacy on cognition at weeks 9 and 14 by a factor 9.7 (95% CI:1.2-81.1) and 9.9 (95% CI:1.1-88.4), respectively (p?0.04)...
  50. Hassan Y, Zhu H, Zhu Y, Zhou T. Beyond Ribosomal Binding: The Increased Polarity and Aberrant Molecular Interactions of 3-epi-deoxynivalenol. Toxins (Basel). 2016;8: pubmed publisher
    ..mechanistically attributed it to the reduced binding of 3-epi-DON within the ribosomal peptidyl transferase center (PTC)...
  51. Krejmer Rabalska M, Rabalski L, Lobo de Souza M, Moore S, Szewczyk B. New Method for Differentiation of Granuloviruses (Betabaculoviruses) Based on Multitemperature Single Stranded Conformational Polymorphism. Int J Mol Sci. 2017;19: pubmed publisher
    ..Afterwards, products of PCR reaction were analysed by MSSCP technique. In our opinion, the proposed method may be used for screening of new isolates derived from environmental samples. ..
  52. Wang N, Zhang M, Thompson A, Chen S. Factor IX Chongqing: a new mutation in the calcium-binding domain of factor IX resulting in severe hemophilia B. Thromb Haemost. 1990;63:24-6 pubmed
    ..In leukocyte DNA from the patient's mother, the nucleotide sequence of exon 2 was entirely normal. Thus, barring somatic mosaicism within her germ cells, the new mutation occurred in oogenesis of her ovary. ..
  53. Tuccilli C, Baldini E, Sorrenti S, Di Gioia C, Bosco D, Ascoli V, et al. PAPILLARY THYROID CANCER IS CHARACTERIZED BY ALTERED EXPRESSION OF GENES INVOLVED IN THE SUMOYLATION PROCESS. J Biol Regul Homeost Agents. 2015;29:655-62 pubmed
    ..of all the components of the sumoylation machinery in a case study comprising 77 papillary thyroid cancers (PTC) and normal matched tissues...
  54. Tam A, Ozdemir D, Cuhaci N, Baser H, Aydin C, Yazgan A, et al. Association of multifocality, tumor number, and total tumor diameter with clinicopathological features in papillary thyroid cancer. Endocrine. 2016;53:774-83 pubmed publisher
    Tumor multifocality is not an unusual finding in papillary thyroid carcinoma (PTC), but its clinical significance is controversial...
  55. Hartfield M, Glemin S. Limits to Adaptation in Partially Selfing Species. Genetics. 2016;203:959-74 pubmed publisher
    In outcrossing populations, "Haldane's sieve" states that recessive beneficial alleles are less likely to fix than dominant ones, because they are less exposed to selection when rare...
  56. Bisicchia S, Scordo G, Prins J, Tudisco C. Do ethnicity and gender influence posterior tibial slope?. J Orthop Traumatol. 2017;18:319-324 pubmed publisher
    ..tibial slope was calculated (rater 1) in lateral view X-rays of the knee according to the posterior tibial cortex (PTC) and tibial proximal anatomical axis (TPAA) methods. Data were matched with ethnicity and gender...
  57. Zepeda Orozco D, Wen H, Hamilton B, Raikwar N, Thomas C. EGF regulation of proximal tubule cell proliferation and VEGF-A secretion. Physiol Rep. 2017;5: pubmed publisher
    Proximal tubule cell (PTC) proliferation is critical for tubular regeneration and recovery from acute kidney injury...
  58. Gao Y, Fang X, Vincent D, Threadgill D, Bartholin L, Li Q. Disruption of postnatal folliculogenesis and development of ovarian tumor in a mouse model with aberrant transforming growth factor beta signaling. Reprod Biol Endocrinol. 2017;15:94 pubmed publisher
    ..effects of dysregulated TGFB signaling in the ovary using Cre recombinase driven by growth differentiation factor 9 (Gdf9) promoter known to be expressed in oocytes...
  59. Marcinkiewicz M, Sinha D, Walsh P. Productive recognition of factor IX by factor XIa exosites requires disulfide linkage between heavy and light chains of factor XIa. J Biol Chem. 2012;287:6187-95 pubmed publisher
    In the intrinsic pathway of blood coagulation factor XIa (FXIa) activates factor IX (FIX) by cleaving the zymogen at Arg(145)-Ala(146) and Arg(180)-Val(181) bonds releasing an 11-kDa activation peptide...
  60. Saini S, Hamasaki Katagiri N, Pandey G, Yanover C, Guelcher C, Simhadri V, et al. Genetic determinants of immunogenicity to factor IX during the treatment of haemophilia B. Haemophilia. 2015;21:210-8 pubmed publisher
    ..0018) median affinity for FIX-derived peptides in the sibling that responded to ITI...
  61. Philogene M, Bagnasco S, Kraus E, Montgomery R, Dragun D, Leffell M, et al. Anti-Angiotensin II Type 1 Receptor and Anti-Endothelial Cell Antibodies: A Cross-Sectional Analysis of Pathological Findings in Allograft Biopsies. Transplantation. 2017;101:608-615 pubmed publisher
    ..004). Glomerulitis (g) and peritubular capillaritis (ptc) scores were independently correlated with increased AT1R-Ab concentrations in the presence or absence of HLA-DSA (..
  62. He W, Huang P, Liu D, Zhong L, Yu R, Li J. Polymorphism of the XRCC1 Gene Is Associated with Susceptibility and Short-Term Recovery of Ischemic Stroke. Int J Environ Res Public Health. 2016;13: pubmed
    i>Background: Base excision repair (BER) is the primary DNA repair system with the ability to fix base lesions caused by oxidative damage...
  63. Gerbracht J, Boehm V, Gehring N. Plasmid transfection influences the readout of nonsense-mediated mRNA decay reporter assays in human cells. Sci Rep. 2017;7:10616 pubmed publisher
    ..assesses the fidelity of transcripts and eliminates mRNAs containing a premature translation termination codon (PTC). When studying mRNA degradation pathways, reporter mRNAs are commonly expressed in cultivated cells...
  64. Wiggers J, Groot Koerkamp B, Coelen R, Rauws E, Schattner M, Nio C, et al. Preoperative biliary drainage in perihilar cholangiocarcinoma: identifying patients who require percutaneous drainage after failed endoscopic drainage. Endoscopy. 2015;47:1124-31 pubmed publisher
    ..with potentially resectable perihilar cholangiocarcinoma (PHC), but additional percutaneous transhepatic catheter (PTC) drainage is frequently required...
  65. Lo T, Uy A, Maningat P. Well-Differentiated Thyroid Cancer: The Philippine General Hospital Experience. Endocrinol Metab (Seoul). 2016;31:72-9 pubmed publisher
    ..3.7%) presenting with distant metastases. Nodal metastases at presentation were more frequent among patients with PTC (29.9% vs. 7.6%)...
  66. Kim C, Lee C, An K, Gwak H, Kim J, Wang L, et al. Predictors of reduction loss in tibial plateau fracture surgery: Focusing on posterior coronal fractures. Injury. 2016;47:1483-7 pubmed publisher
    ..001 and 0.009, respectively). When a tibial plateau fracture has a coronal fracture, if it is difficult to fix its fragments rigidly with medial or lateral plate fixation; therefore, buttress plating or direct fixation of ..
  67. Perdas E, Stawski R, Nowak D, Zubrzycka M. The Role of miRNA in Papillary Thyroid Cancer in the Context of miRNA Let-7 Family. Int J Mol Sci. 2016;17: pubmed publisher
    Papillary thyroid carcinoma (PTC) is the most common endocrine malignancy...
  68. Garcia Rendueles A, Rodrigues J, Garcia Rendueles M, Suarez Fariña M, Perez Romero S, Barreiro F, et al. Rewiring of the apoptotic TGF-β-SMAD/NFκB pathway through an oncogenic function of p27 in human papillary thyroid cancer. Oncogene. 2017;36:652-666 pubmed publisher
    Papillary thyroid carcinoma (PTC), the most frequent thyroid cancer, is characterized by low proliferation but no apoptosis, presenting frequent lymph-node metastasis...
  69. Homayouni M, Mohammad Arabzadeh S, Nili F, Razi F, Amoli M. Evaluation of the presence of Epstein-Barr virus (EBV) in Iranian patients with thyroid papillary carcinoma. Pathol Res Pract. 2017;213:854-856 pubmed publisher
    Papillary thyroid carcinoma (PTC) is the most common thyroid cancer. EBV is one of the most important viruses related to different types of malignancies...
  70. Nathwani A, Davidoff A, Tuddenham E. Gene Therapy for Hemophilia. Hematol Oncol Clin North Am. 2017;31:853-868 pubmed publisher
    ..In stark contrast, gene therapy holds out the hope of a cure by inducing continuous endogenous expression of factor VIII or factor IX following transfer of a functional gene to replace the hemophilic patient's own defective gene. ..
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    ..Although effective, none of these techniques fix iris-malposition and angle recession...
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    ..Based on these results we conclude that residues of the 39-loop regulate the cofactor-independent interaction of FIXa with its physiological inhibitor AT and substrate factor X. ..
  73. Albright E, Kalejta R. Myeloblastic cell lines mimic some but not all aspects of human cytomegalovirus experimental latency defined in primary CD34+ cell populations. J Virol. 2013;87:9802-12 pubmed publisher
    ..Furthermore, while the clinical strain FIX was able to reactivate from Kasumi-3 cells, AD169 was not, and neither strain reactivated from KG-1 cells...
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    ..However, the need to fix the tree topology currently limits GSS in a coalescent-based framework...
  75. Sanyal S. Biomedical Enhancement and Social Development: A Conservative Techno-Fix. Bioethics. 2016;30:733-740 pubmed publisher
    ..To make the case, I distinguish conservatism in ethics from conservatism in politics; and I contextualize the proposal against the background of development economics and the neoliberal approach to development. ..
  76. Carriel V, Campos F, Aneiros Fernández J, Kiernan J. Tissue Fixation and Processing for the Histological Identification of Lipids. Methods Mol Biol. 2017;1560:197-206 pubmed publisher
    ..Here we describe methods to fix and process tissue samples for the histochemical identification of lipids in frozen or paraffin-embedded tissues.
  77. Park E, Lim D, Lim S. Dual-Band Band-Pass Filter with Fixed Low Band and Fluidically-Tunable High Band. Sensors (Basel). 2017;17: pubmed publisher
    ..Using this characteristic, we fix the lower resonant frequency by fixing the SRR length and tune the higher resonant frequency by controlling the ..
  78. Davidson M, Olsen R, Ewton A, Robbins R. PANCREAS METASTASES FROM PAPILLARY THYROID CARCINOMA: A REVIEW OF THE LITERATURE. Endocr Pract. 2017;: pubmed publisher
    Although loco-regional metastases occur in 5-10% of patients with papillary thyroid cancer (PTC), distant metastases are rare, especially to the pancreas...
  79. Iwata H, Kaibara M. Activation of factor IX by erythrocyte membranes causes intrinsic coagulation. Blood Coagul Fibrinolysis. 2002;13:489-96 pubmed
    ..Western blot analysis of coagulation factors incubated with erythrocytes (RBCs) showed that only factor IX (FIX) was activated by RBC membranes in the presence of calcium ions...
  80. Castro L, Alves S, Chaves S, Costa J, Soares P, Preto A. RAF-1 promotes survival of thyroid cancer cells harboring RET/PTC1 rearrangement independently of ERK activation. Mol Cell Endocrinol. 2015;415:64-75 pubmed publisher
    Thyroid cancer (TC) is frequently associated with BRAF or RAS oncogenic mutations and RET/PTC rearrangements, with aberrant RAF-MEK-ERK and/or PI3K pathway activation...
  81. Liu Y, Jiang G, He G. Enhancement of entangled porous titanium by BisGMA for load-bearing biomedical applications. Mater Sci Eng C Mater Biol Appl. 2016;61:37-41 pubmed publisher
    The Bisphenol A glycidyl methacrylate (BisGMA) was used as binder to fix the free cross wire nodes in the entangled porous titanium for enhancement. The entangled titanium with 60% porosity after infiltrated with 5-20 vol...
  82. Gao Q, Wang N, Duan H, Zhou Y, Zhang W, Zhao D. [Study on the correlation between BRAF(V600E) mutation and lymphatic metastases in papillary thyroid cancer staged preoperativelv as N0]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015;29:2048-52 pubmed
    To study the prevalence of BRAF(V600E) mutations in small (≤ 2 cm) papillary thyroid carcinoma (PTC), explore the correlation with occult central nodal metastasis (CNM) of clinically-nodal negative (cN0) neck for small (≤ 2 cm) ..
  83. Li T, Yang X, Ye C, Shen Z, Yang Y, Wang B, et al. Long noncoding RNA HIT000218960 promotes papillary thyroid cancer oncogenesis and tumor progression by upregulating the expression of high mobility group AT-hook 2 (HMGA2) gene. Cell Cycle. 2017;16:224-231 pubmed publisher
    ..To explore the crucial lncRNAs involved in oncogenesis of papillary thyroid cancer (PTC), we acquired data of differentially expressed lncRNAs between PTC tissues and paired adjacent noncancerous thyroid ..
  84. Igarashi K, Kato S. Extracellular electron transfer in acetogenic bacteria and its application for conversion of carbon dioxide into organic compounds. Appl Microbiol Biotechnol. 2017;101:6301-6307 pubmed publisher
    ..e., acetogens) produce acetate from CO2 during anaerobic chemoautotrophic growth. Because acetogens fix CO2 with high energy efficiency, they have been investigated as biocatalysts of CO2 ..
  85. Liang Z, Xie W, Zhao M, Cheng G, Wu M. DDR2 facilitates papillary thyroid carcinoma epithelial mesenchymal transition by activating ERK2/Snail1 pathway. Oncol Lett. 2017;14:8114-8121 pubmed publisher
    ..epithelial-mesenchymal transition (EMT); however, the expression profile of DDR2 in papillary thyroid carcinoma (PTC) with local metastasis and the effect of DDR2 on PTC cells remain unknown...
  86. McGraw R, Davis L, Noyes C, Lundblad R, Roberts H, Graham J, et al. Evidence for a prevalent dimorphism in the activation peptide of human coagulation factor IX. Proc Natl Acad Sci U S A. 1985;82:2847-51 pubmed
    We have independently isolated and characterized cDNA and genomic clones for the human coagulation factor IX. Sequence analysis in both cases indicates that threonine is encoded by the triplet ACT as the third residue of the activation ..
  87. Arellano A, Bezemer I, Tong C, Catanese J, Devlin J, Reitsma P, et al. Gene variants associated with venous thrombosis: confirmation in the MEGA study. J Thromb Haemost. 2010;8:1132-4 pubmed publisher
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    ..However, both patients had a history of papillary thyroid carcinoma (PTC) from several years ago and BRAF mutations were observed in the undifferentiated tumors, as well as in the previous ..
  89. Qiu Z, Li H, Wang J, Sun C. miR-146a and miR-146b in the diagnosis and prognosis of papillary thyroid carcinoma. Oncol Rep. 2017;38:2735-2740 pubmed publisher
    ..Finally, western blot analysis was used to analyze the expression of IRAK1 in PTC cancer cells...
  90. Luo D, Xu X, Ding J, Zhang Y, Peng Y, Pan G, et al. Clinical value and indication for the dissection of lymph nodes posterior to the right recurrent laryngeal nerve in papillary thyroid carcinoma. Oncotarget. 2017;8:79897-79905 pubmed publisher
    ..laryngeal nerve (LN-prRLN) are common sites of nodal recurrence after the resection of papillary thyroid carcinoma (PTC). However, the indication for LN-prRLN dissection remains debatable...
  91. de la Salle C, Charmantier J, Baas M, Schwartz A, Wiesel M, Grunebaum L, et al. A deletion located in the 3' non translated part of the factor IX gene responsible for mild haemophilia B. Thromb Haemost. 1993;70:370-1 pubmed
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    ..8 nm). With excess zymogen (FIX) to block shared FIX/FIXa-binding sites, the stoichiometry of 125I-FIXa and 131I-FVIIIa binding was 1:4...