Gene Symbol: F8
Description: coagulation factor VIII
Alias: AHF, DXS1253E, F8B, F8C, FVIII, HEMA, coagulation factor VIII, antihemophilic factor, coagulation factor VIII A1 domain, coagulation factor VIII C2 domain, coagulation factor VIII, procoagulant component, coagulation factor VIIIc, factor VIII F8B
Species: human
Products:     F8

Top Publications

  1. Viel K, Machiah D, Warren D, Khachidze M, Buil A, Fernstrom K, et al. A sequence variation scan of the coagulation factor VIII (FVIII) structural gene and associations with plasma FVIII activity levels. Blood. 2007;109:3713-24 pubmed
    Plasma factor VIII coagulant activity (FVIII:C) level is a highly heritable quantitative trait that is strongly correlated with thrombosis risk...
  2. Brinkman H, van Mourik J, Mertens K. Persistent factor VIII-dependent factor X activation on endothelial cells is independent of von Willebrand factor. Blood Coagul Fibrinolysis. 2008;19:190-6 pubmed publisher
    ..Although previous studies have shown that von Willebrand factor modulates factor VIII activation and stabilisation, this apparently does not affect the progression of factor X activation at the endothelium. ..
  3. Shovlin C, Sulaiman N, Govani F, Jackson J, Begbie M. Elevated factor VIII in hereditary haemorrhagic telangiectasia (HHT): association with venous thromboembolism. Thromb Haemost. 2007;98:1031-9 pubmed
    ..In the pilot study, factor VIII (FVIII) and von Willebrand factor antigen concentrations were elevated in the HHT group compared to non-HHT controls (p&..
  4. van den Biggelaar M, Bierings R, Storm G, Voorberg J, Mertens K. Requirements for cellular co-trafficking of factor VIII and von Willebrand factor to Weibel-Palade bodies. J Thromb Haemost. 2007;5:2235-42 pubmed
    ..While it is generally believed that FVIII and VWF assemble in circulation after secretion from different cells, an alternative view is that cells should ..
  5. Bajaj S, Schmidt A, Mathur A, Padmanabhan K, Zhong D, Mastri M, et al. Factor IXa:factor VIIIa interaction. helix 330-338 of factor ixa interacts with residues 558-565 and spatially adjacent regions of the a2 subunit of factor VIIIa. J Biol Chem. 2001;276:16302-9 pubmed
    ..These data support a conclusion that the helix 330 of factor IXa interacts with the A2 558-565 sequence. This information was used to model the interface between the IXa protease domain and the A2 subunit, which is also provided herein. ..
  6. Martin Salces M, Venceslá A, Alvárez Román M, Rivas I, Fernandez I, Butta N, et al. Clinical and genetic findings in five female patients with haemophilia A: Identification of a novel missense mutation, p.Phe2127Ser. Thromb Haemost. 2010;104:718-23 pubmed publisher
    ..Phe2127Ser. The mutation is predicted to impair binding to the factor VIII (FVIII) carrier protein, von Willebrand factor, and thus increased clearance of FVIII from plasma...
  7. El Maarri O, Herbiniaux U, Graw J, Schroder J, Terzic A, Watzka M, et al. Analysis of mRNA in hemophilia A patients with undetectable mutations reveals normal splicing in the factor VIII gene. J Thromb Haemost. 2005;3:332-9 pubmed
    haemophilia A (HA) is characterized by partial or total deficiency of factor VIII (FVIII) protein activity. It is caused by a broad spectrum of mutations in the FVIII gene...
  8. Wakabayashi H, Su Y, Ahmad S, Walsh P, Fay P. A Glu113Ala mutation within a factor VIII Ca2+-binding site enhances cofactor interactions in factor Xase. Biochemistry. 2005;44:10298-304 pubmed
  9. Newell J, Fay P. Cleavage at Arg-1689 influences heavy chain cleavages during thrombin-catalyzed activation of factor VIII. J Biol Chem. 2009;284:11080-9 pubmed publisher
    ..Overall, these results are consistent with a competition between heavy and light chains for thrombin exosite binding and subsequent proteolysis with binding of the former chain preferred. ..

More Information


  1. van den Biggelaar M, Bouwens E, Kootstra N, Hebbel R, Voorberg J, Mertens K. Storage and regulated secretion of factor VIII in blood outgrowth endothelial cells. Haematologica. 2009;94:670-8 pubmed publisher
    ..In this study, we explored the feasibility of blood outgrowth endothelial cells as a cellular FVIII delivery device with particular reference to long-term production levels, intracellular storage in Weibel-Palade ..
  2. Morange P, Saut N, Antoni G, Emmerich J, Tregouet D. Impact on venous thrombosis risk of newly discovered gene variants associated with FVIII and VWF plasma levels. J Thromb Haemost. 2011;9:229-31 pubmed publisher
  3. Jayandharan G, Shaji R, Baidya S, Nair S, Chandy M, Srivastava A. Identification of factor VIII gene mutations in 101 patients with haemophilia A: mutation analysis by inversion screening and multiplex PCR and CSGE and molecular modelling of 10 novel missense substitutions. Haemophilia. 2005;11:481-91 pubmed
    Haemophilia A (HA) is an X-linked bleeding disorder caused by diverse mutations in the human coagulation factor VIII (FVIII) gene. We have analysed DNA from 109 unrelated Indian patients with HA for their FVIII gene defects...
  4. Ward N, Buckley S, Waddington S, VandenDriessche T, Chuah M, Nathwani A, et al. Codon optimization of human factor VIII cDNAs leads to high-level expression. Blood. 2011;117:798-807 pubmed publisher
    ..therapy for hemophilia A would be facilitated by development of smaller expression cassettes encoding factor VIII (FVIII), which demonstrate improved biosynthesis and/or enhanced biologic properties...
  5. Gouw S, van den Berg H, Oldenburg J, Astermark J, de Groot P, Margaglione M, et al. F8 gene mutation type and inhibitor development in patients with severe hemophilia A: systematic review and meta-analysis. Blood. 2012;119:2922-34 pubmed publisher
    ..review was designed to provide more precise effect estimates of inhibitor development for the various types of F8 gene mutations in patients with severe hemophilia A...
  6. Liu M, Murphy M, Thompson A. A domain mutations in 65 haemophilia A families and molecular modelling of dysfunctional factor VIII proteins. Br J Haematol. 1998;103:1051-60 pubmed
    ..Mutant side-chain substitutions were inserted to predict changes in surface groups or, for buried residues, potential surface areas whose structure is probably disrupted by the substitution. ..
  7. Gouw S, van der Bom J, Van den Berg H, Zewald R, Ploos van Amstel J, Mauser Bunschoten E. Influence of the type of F8 gene mutation on inhibitor development in a single centre cohort of severe haemophilia A patients. Haemophilia. 2011;17:275-81 pubmed publisher
    The development of neutralizing antibodies against factor VIII (FVIII) is a major complication of treatment with FVIII in patients with severe haemophilia A...
  8. Elmahmoudi H, Belhedi N, Jlizi A, Zahra K, Meddeb B, Ben Ammar Elgaaied A, et al. Factor VIII haplotypes frequencies in Tunisian hemophiliacs A. Diagn Pathol. 2011;6:54 pubmed publisher
    The development of inhibitors against factor 8 (F8) is the most serious complication of replacement therapy with F8 in children with severe hemophilia...
  9. Moghimi B, Sack B, Nayak S, Markusic D, Mah C, Herzog R. Induction of tolerance to factor VIII by transient co-administration with rapamycin. J Thromb Haemost. 2011;9:1524-33 pubmed publisher
    ..Similarly, hemophilia A mice develop high-titer inhibitors to recombinant human FVIII after a few intravenous injections...
  10. Cutler J, Mitchell M, Smith M, Savidge G. The identification and classification of 41 novel mutations in the factor VIII gene (F8C). Hum Mutat. 2002;19:274-8 pubmed
    Hemophilia A is a bleeding disorder caused by a quantitative or qualitative deficiency in the coagulation factor VIII. Causative mutations are heterogeneous in nature and are distributed throughout the FVIII gene...
  11. Abou Elew H, Ahmed H, Raslan H, Abdelwahab M, Hammoud R, Mokhtar D, et al. Genotyping of intron 22-related rearrangements of F8 by inverse-shifting PCR in Egyptian hemophilia A patients. Ann Hematol. 2011;90:579-84 pubmed publisher
    ..In severe HA, intron 22 inversion of F8 is the most prevalent mutation, accounting for 40-50% of all mutations; however, little is known about the disease-..
  12. Nair P, Shetty S, Kulkarni B, Ghosh K. Molecular pathology of haemophilia A in Indian patients: identification of 11 novel mutations. Clin Chim Acta. 2010;411:2004-8 pubmed publisher
    ..High heterogeneity in mutational profile has been observed in the present study. The outcome of this study would enable us to give an accurate diagnosis in all affected families by direct mutation analysis. ..
  13. Schwaab R, Pavlova A, Albert T, Caspers M, Oldenburg J. Significance of F8 missense mutations with respect to inhibitor formation. Thromb Haemost. 2013;109:464-70 pubmed publisher
    ..While missense mutations are strongly underrepresented within the factor VIII (FVIII) B-domain, they are evenly distributed throughout the entire F8 cDNA sequence...
  14. Ngo J, Huang M, Roth D, Furie B, Furie B. Crystal structure of human factor VIII: implications for the formation of the factor IXa-factor VIIIa complex. Structure. 2008;16:597-606 pubmed publisher
    ..This model provides insight into the activation of factor VIII and the interaction of factor VIIIa with factor IXa on the membrane surface. ..
  15. Abu Amero K, Hellani A, Al Mahed M, Al Sheikh I. Spectrum of factor VIII mutations in Arab patients with severe haemophilia A. Haemophilia. 2008;14:484-8 pubmed publisher
    Haemophilia A is an X-linked recessive bleeding disorder caused by mutations in the factor VIII (FVIII) gene. The mutation spectrum is known in various populations, but not in Arabs...
  16. Wakabayashi H, Fay P. Identification of residues contributing to A2 domain-dependent structural stability in factor VIII and factor VIIIa. J Biol Chem. 2008;283:11645-51 pubmed publisher
    ..This observation is consistent with an altered conformation involving new inter-subunit interactions involving A2 domain following procofactor activation. ..
  17. Viel K, Ameri A, Abshire T, Iyer R, Watts R, Lutcher C, et al. Inhibitors of factor VIII in black patients with hemophilia. N Engl J Med. 2009;360:1618-27 pubmed publisher
    ..We sequenced the factor VIII gene (F8) in black patients with hemophilia A to identify causative mutations and the background haplotypes on which they ..
  18. Awidi A, Ramahi M, Alhattab D, Mefleh R, Dweiri M, Bsoul N, et al. Study of mutations in Jordanian patients with haemophilia A: identification of five novel mutations. Haemophilia. 2010;16:136-42 pubmed publisher
    ..X-linked recessive bleeding disorder caused by mutations in the factor VIII gene (F8), which encodes factor VIII (FVIII) protein, a plasma glycoprotein, that plays an important role in the blood coagulation cascade...
  19. Summers R, Meeks S, Healey J, Brown H, Parker E, Kempton C, et al. Factor VIII A3 domain substitution N1922S results in hemophilia A due to domain-specific misfolding and hyposecretion of functional protein. Blood. 2011;117:3190-8 pubmed publisher
    A point mutation leading to amino acid substitution N1922S in the A3 domain of factor VIII (fVIII) results in moderate to severe hemophilia A...
  20. Renault N, Dyack S, Dobson M, Costa T, Lam W, Greer W. Heritable skewed X-chromosome inactivation leads to haemophilia A expression in heterozygous females. Eur J Hum Genet. 2007;15:628-37 pubmed
    ..of HA in three heterozygous females within an Atlantic Canadian kindred, the proband (severely affected girl, FVIII activity: 2%) and 17 relatives across three generations were studied...
  21. Habart D, Kalabova D, Novotny M, Vorlova Z. Thirty-four novel mutations detected in factor VIII gene by multiplex CSGE: modeling of 13 novel amino acid substitutions. J Thromb Haemost. 2003;1:773-81 pubmed
    ..Our objective was to identify defects in the gene of FVIII by a sensitive and simple scanning technique with high throughput in order to study molecular mechanisms by which ..
  22. Nogami K, Wakabayashi H, Schmidt K, Fay P. Altered interactions between the A1 and A2 subunits of factor VIIIa following cleavage of A1 subunit by factor Xa. J Biol Chem. 2003;278:1634-41 pubmed
    ..Furthermore, the C terminus of A1 contributes to the K(m) for factor X binding to factor Xase, and this parameter is critical for activity assessed in plasma-based assays. ..
  23. Bicocchi M, Pasino M, Lanza T, Bottini F, Molinari A, Caprino D, et al. Small FVIII gene rearrangements in 18 hemophilia A patients: five novel mutations. Am J Hematol. 2005;78:117-22 pubmed
    Hemophilia A (HA) is a disorder caused by mutations of the FVIII gene, which is located on the tip of the long arm of the X chromosome...
  24. Andrikovics H, Klein I, Bors A, Nemes L, Marosi A, Varadi A, et al. Analysis of large structural changes of the factor VIII gene, involving intron 1 and 22, in severe hemophilia A. Haematologica. 2003;88:778-84 pubmed
    Hemophilia A (HA), the deficiency of coagulation factor VIII (FVIII), is the most common, sex-linked inherited bleeding disorder...
  25. Wakabayashi H, Freas J, Zhou Q, Fay P. Residues 110-126 in the A1 domain of factor VIII contain a Ca2+ binding site required for cofactor activity. J Biol Chem. 2004;279:12677-84 pubmed
  26. Jacquemin M, Neyrinck A, Hermanns M, Lavend homme R, Rega F, Saint Remy J, et al. FVIII production by human lung microvascular endothelial cells. Blood. 2006;108:515-7 pubmed
    While extrahepatic factor VIII (FVIII) synthesis suffices for hemostasis, the extrahepatic production sites are not well defined. We therefore investigated the ability of the human lungs to produce FVIII...
  27. El Maarri O, Singer H, Klein C, Watzka M, Herbiniaux U, Brackmann H, et al. Lack of F8 mRNA: a novel mechanism leading to hemophilia A. Blood. 2006;107:2759-65 pubmed
    Hemophilia A (HA) is caused by partial or total deficiency of F8 protein activity. In a small group, about 1.8% of patients with HA, no mutation is found in the F8 gene...
  28. Bogdanova N, Markoff A, Pollmann H, Nowak Gottl U, Eisert R, Wermes C, et al. Spectrum of molecular defects and mutation detection rate in patients with severe hemophilia A. Hum Mutat. 2005;26:249-54 pubmed
    ..Various types of mutations in the F8 gene are causative for this condition...
  29. Bovenschen N, Rijken D, Havekes L, van Vlijmen B, Mertens K. The B domain of coagulation factor VIII interacts with the asialoglycoprotein receptor. J Thromb Haemost. 2005;3:1257-65 pubmed
    b>Coagulation factor VIII (FVIII) is a heavily glycosylated heterodimeric plasma protein that consists of a heavy (domains A1-A2-B) and light chain (domains A3-C1-C2)...
  30. Ahmed R, Ivaskevicius V, Kannan M, Seifried E, Oldenburg J, Saxena R. Identification of 32 novel mutations in the factor VIII gene in Indian patients with hemophilia A. Haematologica. 2005;90:283-4 pubmed
    ..In the remaining 51 patients without inversions screening the FVIII gene by denaturing high performance liquid chromatography (DHPLC) revealed 42 different mutations in 44 unrelated ..
  31. McMullen B, Fujikawa K, Davie E, Hedner U, Ezban M. Locations of disulfide bonds and free cysteines in the heavy and light chains of recombinant human factor VIII (antihemophilic factor A). Protein Sci. 1995;4:740-6 pubmed
    ..The positions of the three free cysteines of factor VIII are the same as three of the four cysteines present in ceruloplasmin. However, the positions of the free cysteines in factor VIII and ceruloplasmin are not conserved in factor V. ..
  32. Pittman D, Wang J, Kaufman R. Identification and functional importance of tyrosine sulfate residues within recombinant factor VIII. Biochemistry. 1992;31:3315-25 pubmed
    ..These results suggest that tyrosine sulfation is required for full factor VIII activity and may affect the interaction of factor VIII with other components of the coagulation cascade. ..
  33. Lakich D, Kazazian H, Antonarakis S, Gitschier J. Inversions disrupting the factor VIII gene are a common cause of severe haemophilia A. Nat Genet. 1993;5:236-41 pubmed
    ..We present evidence to support this model and describe a Southern blot assay that detects the inversion. These findings should be valuable for genetic prediction of haemophilia A in approximately 45% of families with severe disease. ..
  34. Kamikubo Y, Mendolicchio G, Zampolli A, Marchese P, Rothmeier A, Orje J, et al. Selective factor VIII activation by the tissue factor-factor VIIa-factor Xa complex. Blood. 2017;130:1661-1670 pubmed publisher
    ..extrinsic tissue factor (TF) coagulation initiation complex can selectively activate the antihemophilic cofactor, FVIII, triggering the hemostatic intrinsic coagulation pathway independently of thrombin feedback loops...
  35. Li J, Wang J, Liu C, Ma D, Ma J. Dynamic relationship between SIPA1 gene and protein expression and the development of gastric cancer. Genet Mol Res. 2017;16: pubmed publisher
    ..SIPA1, VEGF-A, and FVIII levels in 60 gastric tumor and 40 tumor-adjacent normal tissues were examined by immunohistochemical staining...
  36. Alastrué Vidal A, Navinés López J, Julián Ibáñez J, De la Ossa Merlano N, Botey Fernandez M, Sampere Moragues J, et al. Adrenohepatic fusion: Adhesion or invasion in primary virilizant giant adrenal carcinoma? Implications for surgical resection. Two case report and review of the literature. Int J Surg Case Rep. 2016;18:24-9 pubmed publisher
    ..b>AHF in such cases may be misinterpreted during surgery, what may impair its resectability, and therefore the survival...
  37. Winter P, Egan H, McNulty O, Jones F, O DONNELL J, Jenkins P. A recurrent F8 mutation in Irish haemophilia A patients: evidence for a founder effect. Haemophilia. 2008;14:394-5 pubmed publisher
  38. Girolami A, Cosi E, Ferrari S, Girolami B. Heparin, coumarin, protein C, antithrombin, fibrinolysis and other clotting related resistances: old and new concepts in blood coagulation. J Thromb Thrombolysis. 2018;45:135-141 pubmed publisher
    ..These patients often show an increased ratio between FVIII levels and protein C...
  39. Erol K. Polychelated cryogels: hemoglobin adsorption from human blood. Artif Cells Nanomed Biotechnol. 2017;45:31-38 pubmed
    ..study, the Hb adsorption onto the Cu(II) immobilized poly(2-hydroxyethyl methacrylate-glycidyl methacrylate), poly(HEMA-GMA)-Cu(II), cryogels was investigated under different conditions (pH, interaction time, initial Hb concentration, ..
  40. Camacho R, Miranda G, Oliveira F, Ribeiro F, Pimentel S, Casarin R. Efficacy of different "in-office" desensitizing treatment methods: An in vitro SEM analysis. Am J Dent. 2015;28:342-6 pubmed
    ..1%), hema (36...
  41. Bilgic T, Klok H. Oligonucleotide Immobilization and Hybridization on Aldehyde-Functionalized Poly(2-hydroxyethyl methacrylate) Brushes. Biomacromolecules. 2015;16:3657-65 pubmed publisher
    ..of oligonucleotides, are prepared by surface-initiated atom transfer radical polymerization (SI-ATRP) of HEMA followed by a postpolymerization oxidation step to generate side chain aldehyde groups...
  42. Bloem E, Meems H, van den Biggelaar M, Mertens K, Meijer A. A3 domain region 1803-1818 contributes to the stability of activated factor VIII and includes a binding site for activated factor IX. J Biol Chem. 2013;288:26105-11 pubmed publisher
    ..In the present study, FVIIIa stability and FIXa binding were evaluated in a FVIII-N1810C variant, and two FVIII variants in which residues 1803-1810 and 1811-1818 are replaced by the corresponding ..
  43. Zheng C, Zhang B. Combined deficiency of coagulation factors V and VIII: an update. Semin Thromb Hemost. 2013;39:613-20 pubmed publisher
    Combined deficiency of factor V (FV) and FVIII (F5F8D) is an autosomal recessive bleeding disorder characterized by simultaneous decreases of both coagulation factors...
  44. Schwarz J, Astermark J, Menius E, Carrington M, Donfield S, Gomperts E, et al. F8 haplotype and inhibitor risk: results from the Hemophilia Inhibitor Genetics Study (HIGS) Combined Cohort. Haemophilia. 2013;19:113-8 pubmed publisher
    ..specifically African descent, confers higher risk for development of inhibitory antibodies to factor VIII (FVIII) in haemophilia A...
  45. Schwaab R, Oldenburg J, Kemball Cook G, Albert T, Juhler C, Hanfland P, et al. Assay discrepancy in mild haemophilia A due to a factor VIII missense mutation (Asn694Ile) in a large Danish family. Br J Haematol. 2000;109:523-8 pubmed
    ..As the original amino acid (Asn) is conserved in all known FVIII A2 sequences, but not in ceruloplasmin, we suggest that Asn694 is involved in an A2-specific functional role...
  46. Chen C, Wang Q, Fang X, Xu Q, Chi C, Gu J. Roles of phytanoyl-CoA alpha-hydroxylase in mediating the expression of human coagulation factor VIII. J Biol Chem. 2001;276:46340-6 pubmed
    The coagulation factor VIII (FVIII) is the coagulation factor deficient in the X-chromosome-linked bleeding disorder hemophilia A...
  47. Ovanesov M, Lopatina E, Saenko E, Ananyeva N, Ul yanova L, Plyushch O, et al. Effect of factor VIII on tissue factor-initiated spatial clot growth. Thromb Haemost. 2003;89:235-42 pubmed
    Using time-lapse videomicroscopy, we studied the role of coagulation factor VIII (fVIII) in tissue factor-initiated spatial clot growth on fibroblast monolayers in a thin layer of non-stirred recalcified plasma from healthy donors or ..
  48. Ivaskevicius V, Jurgutis R, Rost S, Muller A, Schmitt C, Wulff K, et al. Lithuanian haemophilia A and B registry comprising phenotypic and genotypic data. Br J Haematol. 2001;112:1062-70 pubmed
    ..The information provided by this registry will be helpful for monitoring the treatment of Lithuanian haemophilia patients and also for reliable genetic counselling of the affected families in the future. ..
  49. Obirikorang Y, Obirikorang C, Anto E, Acheampong E, Batu E, Macaulary F, et al. Knowledge of bloodless medicine among nurses at the Medical/Surgical Directorate of Komfo Anokye Teaching Hospital, Ghana; a descriptive cross sectional study. BMC Res Notes. 2017;10:747 pubmed publisher
    ..2%) had witnessed BM treatment at the medical and surgical directorate with the Tot'hema (44.6%) being the major used drug. Flu-like symptoms (37.0%) and organ damage (50...
  50. Reitter Pfoertner S, von Haeseler A, Horvath B, Sunder Plassmann R, Tiedje V, Pabinger I, et al. Identification of an ancient haemophilia A splice site mutation. Thromb Res. 2012;130:445-50 pubmed publisher
    ..We identified a new splice site mutation in intron 6 of the F8 gene (T to G transition at position -14; c...
  51. Salazar Sanchez L, Jimenez Cruz G, Mendez M, Chaverri P, Alvarado P, Schroder W, et al. Molecular analysis of FVIII gene in severe HA patients of Costa Rica. Hamostaseologie. 2010;30 Suppl 1:S150-2 pubmed
    Haemophilia A (HA) is X-chromosome linked bleeding disorders caused by deficiency of the coagulation factor VIII (FVIII)...
  52. Silva D, Fernandes A, Nunes T, Colaço R, Serro A. The effect of albumin and cholesterol on the biotribological behavior of hydrogels for contact lenses. Acta Biomater. 2015;26:184-94 pubmed publisher
    ..medium, on the frictional response of two model hydrogels for CLs: a hydroxyethylmethacrylate based hydrogel, HEMA/PVP, and a silicone based one, TRIS/NVP/HEMA...
  53. de Carvalho R, Chisini L, Ferruá C, Guiraldo R, Gonini Júnior A, Moura S, et al. The influence of concentration of HEMA on degree of conversion and cytotoxicity of a dental bonding resin. Minerva Stomatol. 2016;65:65-71 pubmed
    This study evaluated the influence of 2-hydroxyethyl methacrylate (HEMA) on the degree of conversion (DC) and cytotoxicity of a dental bonding resin (DBR). A monomer mixture based on 61...
  54. Shirakabe A, Hata N, Kobayashi N, Okazaki H, Matsushita M, Shibata Y, et al. Clinical Usefulness of Urinary Liver Fatty Acid-Binding Protein Excretion for Predicting Acute Kidney Injury during the First 7 Days and the Short-Term Prognosis in Acute Heart Failure Patients with Non-Chronic Kidney Disease. Cardiorenal Med. 2017;7:301-315 pubmed publisher
    The clinical significance of urinary liver fatty acid-binding protein (u-LFABP) in acute heart failure (AHF) patients remains unclear.
  55. ter Avest P, Fischer K, Mancuso M, Santagostino E, Yuste V, Van den Berg H, et al. Risk stratification for inhibitor development at first treatment for severe hemophilia A: a tool for clinical practice. J Thromb Haemost. 2008;6:2048-54 pubmed publisher
    ..These findings suggest that the development of inhibitory antibodies in untreated patients with severe hemophilia A can validly be predicted with the presented risk stratification score. ..
  56. Castaman G, Giacomelli S, Ghiotto R, Boseggia C, Pojani K, Bulo A, et al. Spectrum of mutations in Albanian patients with haemophilia A: identification of ten novel mutations in the factor VIII gene. Haemophilia. 2007;13:311-6 pubmed
    ..These results further emphasize the extreme heterogeneity of the molecular basis of haemophilia A. The low prevalence of intron 22 inversion in Albanian patients with severe haemophilia A should be addressed by further studies. ..
  57. Granovski V, Freitas M, Abreu Neto M, Covas D. Purification and Autoactivation Method for Recombinant Coagulation Factor VII. Methods Mol Biol. 2018;1674:221-226 pubmed publisher
    ..treatment of hemophiliac patients (hemophilia A/B) who develop inhibitors antibodies to conventional treatments (FVIII and FIX). The rFVII is a glycosylated molecule and circulates in plasma as zymogen of 50 kDa...
  58. Baeken C, Lefaucheur J, Van Schuerbeek P. The impact of accelerated high frequency rTMS on brain neurochemicals in treatment-resistant depression: Insights from 1H MR spectroscopy. Clin Neurophysiol. 2017;128:1664-1672 pubmed publisher
    ..treatment resistant depressed (TRD) patients participated in this sham-controlled accelerated high frequency (aHF)-rTMS 1H MR spectroscopy study applied to the left dorsolateral prefrontal cortex (DLPFC)...
  59. Hsu T, Pratt K, Thompson A. The factor VIII C1 domain contributes to platelet binding. Blood. 2008;111:200-8 pubmed
    ..Membrane attachment involves the FVIII C2 domain; involvement of the adjacent C1 domain has not been established...
  60. Takeyama M, Wakabayashi H, Fay P. Factor VIII light chain contains a binding site for factor X that contributes to the catalytic efficiency of factor Xase. Biochemistry. 2012;51:820-8 pubmed publisher
    ..ELISA-based binding assays, and chemical cross-linking were employed to assess an interaction between FX and the FVIII light chain (A3C1C2 domains)...
  61. Whelihan M, Orfeo T, Gissel M, Mann K. Coagulation procofactor activation by factor XIa. J Thromb Haemost. 2010;8:1532-9 pubmed publisher
    In the extrinsic pathway, the essential procofactors factor (F) V and FVIII are activated to FVa and FVIIIa by thrombin...
  62. Yavuz H, Andac M, Uzun L, Say R, Denizli A. Molecular recognition based iron removal from human plasma with imprinted membranes. Int J Artif Organs. 2006;29:900-11 pubmed
    The aim of this study is to prepare ion-imprinted poly(2-hydroxyethyl methacrylate) (HEMA) based membranes which can be used for the selective removal of Fe3+ ions from Fe3+-overdosed human plasma...
  63. Plantier J, Rolli V, Ducasse C, Dargaud Y, Enjolras N, Boukerche H, et al. Activated factor X cleaves factor VIII at arginine 562, limiting its cofactor efficiency. J Thromb Haemost. 2010;8:286-93 pubmed publisher
    Factor VIII (FVIII) and its activated form (FVIIIa) are subject to proteolysis that dampens their cofactor function...
  64. Zampino A, Masters F, Bladholm E, Panzner M, Berry S, Leeper T, et al. Mercury metallation of the copper protein azurin and structural insight into possible heavy metal reactivity. J Inorg Biochem. 2014;141:152-160 pubmed publisher
  65. Parker E, Doering C, Lollar P. A1 subunit-mediated regulation of thrombin-activated factor VIII A2 subunit dissociation. J Biol Chem. 2006;281:13922-30 pubmed
    Factor VIII (fVIII) is the plasma protein that is missing or deficient in hemophilia A. In contrast, elevated levels of fVIII are associated with an increased risk of arterial and venous thrombosis...
  66. Acquila M, Pasino M, Lanza T, Molinari A, Rosano C, Bicocchi M. Exon skipping partially restores factor VIII coagulant activity in patients with mild hemophilia A with exon 13 duplication. Haematologica. 2005;90:997-9 pubmed
    ..The larger-sized transcript contains both duplicated exons 13, the smaller one contains only one exon 13. The residual FVIII:C activity which accounts for the mild hemophilia A phenotype derives from the latter transcript.
  67. Moghadam M, Pioletti D. Biodegradable HEMA-based hydrogels with enhanced mechanical properties. J Biomed Mater Res B Appl Biomater. 2016;104:1161-9 pubmed publisher
    ..this work, an original formulation of biodegradable photo-crosslinked hydrogels based on hydroxyethyl methacrylate (HEMA) is presented...
  68. Ivaskevicius V, Pezeshkpoor B, Biswas A, Goldmann G, Horneff S, Gimbutyte M, et al. Combined coagulation factor VIII and factor IX deficiency (CDF8F9) in a patient from Lithuania. Hamostaseologie. 2016;36:S29-S33 pubmed
    Haemophilia A (FVIII deficiency) and haemophilia B (FIX deficiency) are X-linked inherited bleeding disorders. It is a very rare event to identify both haemophilias in the same patient...
  69. Rosset C, Gorziza R, Botton M, Salzano F, Bandinelli E. Factor VIII mutations and inhibitor formation in a southern Brazilian population. Blood Coagul Fibrinolysis. 2014;25:125-7 pubmed publisher
    ..patients with severe (n?=?43), moderate (n?=?15) or mild (n?=?52) haemophilia A were studied in relation to their F8 gene mutation and inhibitor status. Nineteen percentage of them had anti-factor VIII antibodies...
  70. Kung F, Sillitti D, Shreiber D, Zahn J, Firestein B. Microfluidic device-assisted etching of p-HEMA for cell or protein patterning. Biotechnol Prog. 2017;: pubmed publisher
    ..Here, we describe a novel method to simply and easily create thin layers of poly (2-hydroxyethyl methacrylate) (p-HEMA) for protein and cellular patterning via etching with ethanol and microfluidic devices...
  71. Rayes J, Ing M, Delignat S, Peyron I, Gilardin L, Vogel C, et al. Complement C3 is a novel modulator of the anti-factor VIII immune response. Haematologica. 2018;103:351-360 pubmed publisher
    Development of neutralizing antibodies against therapeutic Factor VIII (FVIII) is the most serious complication of the treatment of hemophilia A...
  72. Nogami K, Shima M, Hosokawa K, Suzuki T, Koide T, Saenko E, et al. Role of factor VIII C2 domain in factor VIII binding to factor Xa. J Biol Chem. 1999;274:31000-7 pubmed
    Factor VIII (FVIII) is activated by proteolytic cleavages with thrombin and factor Xa (FXa) in the intrinsic blood coagulation pathway...