F7

Summary

Gene Symbol: F7
Description: coagulation factor VII (serum prothrombin conversion accelerator)
Alias: SPCA, FVII coagulation protein, coagulation factor VII, eptacog alfa, proconvertin
Species: human

Top Publications

  1. ncbi [Application of activated eptacog alfa in cardiac surgery]
    Maciej Zagórski
    10 Wojskowy Szpital Kliniczny w Bydgoszczy, Klinika Kardiologii i Kardiochirurgii, Kliniczny Oddzial Kardiochirurgii
    Pol Merkur Lekarski 31:15-9. 2011
  2. ncbi Correlation of polymorphisms to coagulation and biochemical risk factors for cardiovascular diseases
    A H Wu
    Department of Pathology and Laboratory Medicine, Hartford Hospital, Hartford, Connecticut 06102, USA
    Am J Cardiol 87:1361-6. 2001
  3. ncbi Functional characterization of the human factor VII 5'-flanking region
    E S Pollak
    Department of Pediatrics, University of Pennsylvania, Children s Hospital of Philadelphia 19104, USA
    J Biol Chem 271:1738-47. 1996
  4. ncbi Activation of cancer cell migration and invasion by ectopic synthesis of coagulation factor VII
    Shiro Koizume
    Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, Asahi ku, Yokohama 241 0815, Japan
    Cancer Res 66:9453-60. 2006
  5. ncbi Polymorphisms in coagulation factors and the risk of recurrent cardiovascular events in men after a first myocardial infarction
    M D van der Krabben
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    J Thromb Haemost 6:720-5. 2008
  6. ncbi Polymorphisms in prothrombotic genes and their impact on ischemic stroke in a Sardinian population
    Speranza Rubattu
    IRCCS Neuromed, Localita Camerelle, 86077 Pozzilli IS, Italy
    Thromb Haemost 93:1095-100. 2005
  7. ncbi Polymorphisms in platelet glycoprotein 1balpha and factor VII and risk of ischemic stroke: a meta-analysis
    Jane M Maguire
    Neurosciences Department, Gosford Hospital, Northern Sydney Central Coast Health Service, Gosford NSW 2250, Australia
    Stroke 39:1710-6. 2008
  8. ncbi Association between factor VII polymorphisms and blood pressure: the Stanislas Cohort
    Catherine Sass
    Unité INSERM U525, Faculte de Pharmacie, Centre de Medecine Preventive, and Université Henri Poincaré, Nancy, France
    Hypertension 44:674-80. 2004
  9. ncbi R353Q polymorphism, activated factor VII, and risk of premature myocardial infarction in Japanese men
    Masakazu Ogawa
    Department of Cardiovascular, Graduate School of Medicine, Kagoshima University, Japan
    Circ J 68:520-5. 2004
  10. ncbi Association of genetic variants with myocardial infarction in Japanese individuals with chronic kidney disease
    Tetsuo Fujimaki
    Department of Cardiovascular Medicine, Gifu Prefectural Tajimi Hospital, Tajimi, Japan
    Thromb Haemost 101:963-8. 2009

Research Grants

  1. INITIATION AND REGULATION OF BLOOD COAGULATION
    VIJAYA MOHAN RAO LELLA; Fiscal Year: 2010
  2. INITIATION AND REGULATION OF BLOOD COAGULATION
    VIJAYA LELLA; Fiscal Year: 2007
  3. Cardiovascular Disease Epidemiology & Prevention Trng
    Aaron Folsom; Fiscal Year: 2007
  4. Gene and Nutrient Etiologies of Human Heart Defects
    Gary Shaw; Fiscal Year: 2007
  5. New York-Presbyterian NETT Consortium
    Stephan Mayer; Fiscal Year: 2007
  6. PHILA-NETT: Neurological Emergencies Treatment Trials (NETT) Network Clinical Sit
    NINA GENTILE; Fiscal Year: 2007
  7. Fat Induced Insulin Resistance and Atherosclerosis
    Guenther Boden; Fiscal Year: 2007
  8. Hyperglycemia and Hyperinsulinemia Induced Procoagulant State
    Guenther Boden; Fiscal Year: 2010
  9. Estrogens and pharmacogenetic risks of venous thrombosis in postmenopausal women
    Nicholas L Smith; Fiscal Year: 2010
  10. Pharmacologic and pharmacogenetic associations with recurrent venous thrombosis
    Nicholas L Smith; Fiscal Year: 2010

Detail Information

Publications158 found, 100 shown here

  1. ncbi [Application of activated eptacog alfa in cardiac surgery]
    Maciej Zagórski
    10 Wojskowy Szpital Kliniczny w Bydgoszczy, Klinika Kardiologii i Kardiochirurgii, Kliniczny Oddzial Kardiochirurgii
    Pol Merkur Lekarski 31:15-9. 2011
    ..Antybleeding drugs often are out of order. The aim of the study was to assess the efficacy of activated eptacog alfa treatment of patients with massive postoperative bleeding, which can not be controlled with conventional therapy
  2. ncbi Correlation of polymorphisms to coagulation and biochemical risk factors for cardiovascular diseases
    A H Wu
    Department of Pathology and Laboratory Medicine, Hartford Hospital, Hartford, Connecticut 06102, USA
    Am J Cardiol 87:1361-6. 2001
    ..The impact of certain genotypes must be examined in relation to other established risk factors and potentially new therapeutic strategies...
  3. ncbi Functional characterization of the human factor VII 5'-flanking region
    E S Pollak
    Department of Pediatrics, University of Pennsylvania, Children s Hospital of Philadelphia 19104, USA
    J Biol Chem 271:1738-47. 1996
    ..Additionally, the sequence of a naturally occurring allele containing a previously described decanucleotide insert polymorphism at -323 is shown to reduce promoter activity by 33% compared with the more common allelic sequence...
  4. ncbi Activation of cancer cell migration and invasion by ectopic synthesis of coagulation factor VII
    Shiro Koizume
    Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, Asahi ku, Yokohama 241 0815, Japan
    Cancer Res 66:9453-60. 2006
    Blood coagulation factor VII (fVII) is physiologically synthesized in the liver and released into the blood. Binding of fVII to tissue factor (TF) at sites of vascular injury triggers coagulation and hemostasis...
  5. ncbi Polymorphisms in coagulation factors and the risk of recurrent cardiovascular events in men after a first myocardial infarction
    M D van der Krabben
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    J Thromb Haemost 6:720-5. 2008
    ..The aim of this study was to examine whether genetic predisposition to high levels of coagulation factors influences the risk of developing fatal and non-fatal arterial cardiovascular events in men with a first myocardial infarction (MI)...
  6. ncbi Polymorphisms in prothrombotic genes and their impact on ischemic stroke in a Sardinian population
    Speranza Rubattu
    IRCCS Neuromed, Localita Camerelle, 86077 Pozzilli IS, Italy
    Thromb Haemost 93:1095-100. 2005
    ..66, 95% CI 1.06-2.58, P=0.026) on IS occurrence. In summary, we describe evidence for a possible direct association of FVII gene molecular variants with the occurrence of IS in a genetically homogenous human sample...
  7. ncbi Polymorphisms in platelet glycoprotein 1balpha and factor VII and risk of ischemic stroke: a meta-analysis
    Jane M Maguire
    Neurosciences Department, Gosford Hospital, Northern Sydney Central Coast Health Service, Gosford NSW 2250, Australia
    Stroke 39:1710-6. 2008
    ....
  8. ncbi Association between factor VII polymorphisms and blood pressure: the Stanislas Cohort
    Catherine Sass
    Unité INSERM U525, Faculte de Pharmacie, Centre de Medecine Preventive, and Université Henri Poincaré, Nancy, France
    Hypertension 44:674-80. 2004
    ..554, 95% confidence interval [CI], 0.362 to 0.848, and OR=0.475, 95% CI, 0.299 to 0.755, respectively). These results suggest that the FVII gene may be a susceptibility locus for hypertension...
  9. ncbi R353Q polymorphism, activated factor VII, and risk of premature myocardial infarction in Japanese men
    Masakazu Ogawa
    Department of Cardiovascular, Graduate School of Medicine, Kagoshima University, Japan
    Circ J 68:520-5. 2004
    ..The association between myocardial infarction (MI) and the R353Q polymorphism of the Factor VII (FVII) gene, which reportedly influences FVII concentrations, activated Factor VII (FVIIa), or FVII antigen (FVIIag), remains controversial...
  10. ncbi Association of genetic variants with myocardial infarction in Japanese individuals with chronic kidney disease
    Tetsuo Fujimaki
    Department of Cardiovascular Medicine, Gifu Prefectural Tajimi Hospital, Tajimi, Japan
    Thromb Haemost 101:963-8. 2009
    ..initial screen of allele frequencies by the chi-square test revealed that the 11496G-->A (Arg353Gln) polymorphism of F7 (rs6046) was significantly (false discovery rate <0...
  11. ncbi Reduction in coagulation factor VII plasma levels by R353Q but not the -323P0/10 promoter polymorphism in healthy Tunisians
    Nabil Mtiraoui
    Hematological and Autoimmune Diseases Research Unit, Faculté de Pharmacie de Monastir, Université du Centre, Tunisia
    Am J Hematol 79:11-6. 2005
    ..These data suggest that part of the previously described effects on FVIIc levels associated with the R/Q polymorphism may be explained by genetic variation in the promoter region of the FVII gene...
  12. ncbi [The coagulation factor VII gene polymorphisms in patients with myocardial infarction in Ningxia Hui and Han populations]
    Hui Huang
    Center of Cardiology, the Affiliated Hospital of Ningxia Medical College, Yinchuan, Ningxia, 750004 PR China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 26:653-8. 2009
    To investigate the characteristics for activated coagulation factor VII(F VIIa) and the R353Q, -323 0/10 bp, HVR4 polymorphisms in the gene in patients with coronary heart disease (CHD) and myocardial infarction from Ningxia Hui and Han ..
  13. ncbi Genotype associations of factor VII gene with plasma factor VII coagulant activity and antigen levels in healthy Chinese
    Y Liu
    Department of Paediatrics, National University of Singapore, Singapore
    Blood Coagul Fibrinolysis 13:217-24. 2002
    ..In the Chinese, the 10 bp insertion may reduce transcription of the FVII gene, leading to the decreased synthesis of FVII protein and thus FVIIc...
  14. ncbi Coagulation factor VII, R353Q polymorphism, and serum choline-containing phospholipids in males at high risk for coronary heart disease
    Anja S Lindman
    Center for Clinical Research, Ulleval University Hospital, Oslo, Norway
    Thromb Res 113:57-65. 2004
    Elevated levels of coagulation factor VII (FVII) have been associated with increased risk for myocardial infarction (MI)...
  15. ncbi [Association of coagulation factor V, VII gene polymorphisms with coronary heart disease]
    Geng Xu
    Department of Cardiology, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, PR China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 20:39-42. 2003
    ..To study the distribution of coagulation factor V(FV), VII(FVII) gene polymorphisms in Chinese Han population and the association of the polymorphisms with coronary heart disease(CHD)...
  16. ncbi Factor VII activity is an independent predictor of cardiovascular mortality in elderly women of a Sicilian population: results of an 11-year follow-up
    D Noto
    Department of Internal Medicine and Geriatrics, University of Palermo, Italy
    Thromb Haemost 87:206-10. 2002
    ..In conclusion, these findings suggest that in a population with a low risk profile, other factors, such as factor VII activity, may emerge as predictors of cardiovascular mortality...
  17. ncbi Influence of coagulation factor, vitamin K epoxide reductase complex subunit 1, and cytochrome P450 2C9 gene polymorphisms on warfarin dose requirements
    Christina L Aquilante
    Department of Pharmacy Practice, University of Florida College of Pharmacy, Gainesville, FL 32610, USA
    Clin Pharmacol Ther 79:291-302. 2006
    ....
  18. ncbi Tissue factor and coagulation factor VII levels during acute myocardial infarction: association with genotype and adverse events
    Gianluca Campo
    Department of Cardiology, University of Ferrara, 44100 Ferrara, Italy
    Arterioscler Thromb Vasc Biol 26:2800-6. 2006
    We investigated in patients with ongoing myocardial infarction (MI) whether coagulation factor VII (FVII) and tissue factor (TF) levels are affected at admission by genetic components and whether they may predict subsequent cardiovascular ..
  19. ncbi Common genetic variation in five thrombosis genes and relations to plasma hemostatic protein level and cardiovascular disease risk
    Sekar Kathiresan
    National Heart, Lung, and Blood Institute Framingham Heart Study, Framingham, MA 01702 5827, USA
    Arterioscler Thromb Vasc Biol 26:1405-12. 2006
    ..We undertook a linkage disequilibrium (LD)-based genetic approach to investigate the hypothesis that common sequence variants in 5 thrombosis genes influence plasma hemostatic protein levels or risk of cardiovascular disease (CVD)...
  20. ncbi Interrelationships of Factor VII activity and plasma leptin with insulin resistance in coronary heart disease
    Rubina A Karatela
    Jaslok Hospital and Research Centre, Dr G Deshmukh Marg, Mumbai, India
    Atherosclerosis 209:235-40. 2010
    ..Whether FVII is associated with insulin resistance in coronary heart disease (CHD) is still unknown. We tested the hypothesis that plasma FVII activity and leptin are associated with insulin resistance independently...
  21. ncbi Polymorphisms in the factor VII gene and the risk of myocardial infarction in patients with coronary artery disease
    D Girelli
    Department of Clinical and Experimental Medicine, University of Verona, Italy
    N Engl J Med 343:774-80. 2000
    High plasma levels of coagulation factor VII have been suggested to be predictors of death due to coronary artery disease...
  22. ncbi Influence of polymorphisms in the factor VII gene promoter on activated factor VII levels and on the risk of myocardial infarction in advanced coronary atherosclerosis
    Claudia Bozzini
    Department of Clinical and Experimental Medicine, University of Verona, Policlinico G B Rossi, 37134 Verona, Italy
    Thromb Haemost 92:541-9. 2004
    ..This study highlights a "within-gene" interaction, and the need to explore polymorphisms in candidate gene(s) in detail...
  23. ncbi Detection of two missense mutations and characterization of a repeat polymorphism in the factor VII gene (F7)
    G Marchetti
    Centro Studi Biochimici delle Patologie del Genoma Umano, Instituto di Chimica Biologica, Ferrara, Italy
    Hum Genet 89:497-502. 1992
    The 3' portion of the coagulation factor VII gene, containing the activation and serine protease domains, was investigated in four subjects with factor VII deficiency by temperature gradient gel electrophoresis and sequencing of ..
  24. ncbi Factor VII gene intronic mutation in a lethal factor VII deficiency: effects on splice-site selection
    Keren Borensztajn
    INSERM U428, Faculte des Sciences Pharmaceutiques et Biologiques, Universite Paris V, France
    Blood 102:561-3. 2003
    In a patient with lethal factor VII (FVII) deficiency, 2 homozygous nucleotide substitutions were identified in the F7 gene: a IVS7+2T>G transversion involving the IVS7 donor splice site, followed by a mutation at nucleotide 10588 that ..
  25. ncbi Nucleotide sequence of the gene coding for human factor VII, a vitamin K-dependent protein participating in blood coagulation
    F J Grant
    Proc Natl Acad Sci U S A 84:5158-62. 1987
    ..More than a quarter of the intron sequences and more than a third of the 3' untranslated portion of the mRNA transcript consist of these minisatellite tandem repeats...
  26. ncbi Demonstration of the extrinsic coagulation pathway in teleostei: identification of zebrafish coagulation factor VII
    J Sheehan
    Department of Cellular and Structural Biology, South Texas Veteran s Health Care System, Audie Murphy Division, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Proc Natl Acad Sci U S A 98:8768-73. 2001
    ....
  27. ncbi Recombinant factor VIIa (eptacog alfa): a review of its use in congenital hemophilia with inhibitors, acquired hemophilia, and other congenital bleeding disorders
    Katherine F Croom
    Wolters Kluwer Health Adis, Auckland, New Zealand
    BioDrugs 22:121-36. 2008
    Recombinant factor VIIa (NovoSeven; also known as recombinant activated factor VII or eptacog alfa) is structurally similar to human plasma-derived coagulation factor VIIa, but is manufactured using DNA biotechnology...
  28. ncbi [Recombinant activated factor VII in paediatric practice. Universal hemostatic agent?]
    F Monpoux
    Unité d hémato oncologie infantile, Service de Pediatrie, hôpital de l Archet II, 151, Route de Saint Antoine de Ginestiere, 06202 Nice Cedex 3, France
    Arch Pediatr 17:1210-9. 2010
    NovoSeven (eptacog alfa [activated]) is a concentrate of recombinant activated factor VII currently indicated in 3 types of situation: (1) hemorrhagic syndromes in patients with acquired haemophilia or constitutional A or B haemophilia ..
  29. ncbi A coagulation factor VII deficiency protects against acute inflammatory responses in mice
    H Xu
    WM Keck Center for Transgene Research, University of Notre Dame, Notre Dame, IN 46556, USA
    J Pathol 210:488-96. 2006
    ....
  30. ncbi Exclusion of the first EGF domain of factor VII by a splice site mutation causes lethal factor VII deficiency
    J H McVey
    Haemostasis Research Group, MRC Clinical Sciences Centre, ICSM, London, UK
    Blood 92:920-6. 1998
    We have studied a family with homozygous lethal, blood coagulation factor VII (FVII) deficiency...
  31. ncbi Coagulation factors VII and X induce Ca2+ oscillations in Madin-Darby canine kidney cells only when proteolytically active
    E Camerer
    Biotechnology Centre of Oslo, N 0371 Oslo, Norway
    J Biol Chem 271:29034-42. 1996
    We have recently reported that the activated serine protease and blood coagulation Factor VII (FVIIa) can induce Ca2+ oscillations in Madin-Darby canine kidney cells...
  32. ncbi Analysis of the partial nucleotide sequences and deduced primary structures of the protease domains of mammalian blood coagulation factors VII and X
    M Murakawa
    Division of Hematology, Harasanshin General Hospital, Fukuoka, Japan
    Eur J Haematol 52:162-8. 1994
    In order to obtain sequence data for the blood coagulation factor VII and factor X in several mammalian species, we amplified and sequenced the DNA segments of exon VIII from each gene by means of the polymerase chain reaction (PCR) ..
  33. ncbi In vivo demonstration in humans that large postprandial triglyceride-rich lipoproteins activate coagulation factor VII through the intrinsic coagulation pathway
    A Silveira
    Atherosclerosis Research Unit, King Gustaf V Research Institute, Karolinska Hospital, Stockholm, Sweden
    Arterioscler Thromb Vasc Biol 16:1333-9. 1996
    ..Whether activation of factor XI by triglyceride rich lipoproteins initiates these reactions needs to be demonstrated in future studies...
  34. ncbi Characterization of transcriptional regulatory elements in the promoter region of the murine blood coagulation factor VII gene
    D R Stauffer
    Department of Chemistry and Biochemistry, University of Notre Dame, Indiana 46556, USA
    J Biol Chem 273:2277-87. 1998
    To identify the 5' sequences of the murine coagulation factor VII (fVII) gene that resulted in its efficient transcription, a variety of 5'-flanking sequences up to 7 kilobase pairs upstream of the translation ATG initiation codon were ..
  35. ncbi Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin or 2,2',4,4',5,5'-hexachlorobiphenyl on vitamin K-dependent blood coagulation in male and female WAG/Rij-rats
    C A Bouwman
    Research Institute of Toxicology, University of Utrecht, The Netherlands
    Chemosphere 38:489-505. 1999
    ..bw (HxCB) to female and male rats resulted in dose-related reductions of the vitamin K-dependent coagulation factor VII. The highest factor VII reduction in female rats was 44%, observed after TCDD exposure...
  36. ncbi Hemostasis in normotensive and hypertensive men: results of the PROCAM study. The prospective cardiovascular Münster study
    R Junker
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Westfalische Wilhelms Universitat Munster, Germany
    J Hypertens 16:917-23. 1998
    ..The greater than normal cardiovascular risk of hypertensive patients could be partly due to an impairment of hemostatic balance found in such individuals...
  37. ncbi Effect of individual dietary fatty acids on postprandial activation of blood coagulation factor VII and fibrinolysis in healthy young men
    Tine Tholstrup
    Research Department of Human Nutrition and the Center of Advanced Food Research, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark
    Am J Clin Nutr 77:1125-32. 2003
    ..Plasminogen activator inhibitor type 1 (PAI-1) is increased in the presence of hypertriglyceridemia. Free fatty acids (FFAs) in plasma may promote factor VII (FVII) activation...
  38. ncbi A high-fat meal does not activate blood coagulation factor VII in minipigs
    A K Olsen
    Department of Thrombosis Research, University of Southern Denmark
    Blood Coagul Fibrinolysis 12:117-22. 2001
    It is a matter of debate whether postprandial activation of blood coagulation factor VII (FVII) is associated with an increased risk of thrombosis...
  39. ncbi Dietary factor VII activation does not increase plasma concentrations of prothrombin fragment 1+2 in patients with stable angina pectoris and coronary atherosclerosis
    E M Bladbjerg
    Department of Thrombosis Research, The University of Southern Denmark, Esbjerg
    Arterioscler Thromb Vasc Biol 20:2494-9. 2000
    Studies in healthy subjects showed that blood coagulation factor VII (FVII) is activated postprandially after consumption of high-fat meals, but accompanying thrombin formation has not been demonstrated...
  40. ncbi Coagulation factor VII, serum-triglycerides and the R/Q353 polymorphism: differences between older men and women
    L I Mennen
    Department of Epidemiology and Biostatistics, Erasmus University Rotterdam, The Netherlands
    Thromb Haemost 78:984-6. 1997
    b>Coagulation factor VII activity (FVII:C) is a risk indicator for cardiovascular disease...
  41. ncbi Plasma concentrations of blood coagulation factor VII measured by immunochemical and amidolytic methods
    E M Bladbjerg
    Department of Thrombosis Research, University of Southern Denmark, Esbjerg
    Scand J Clin Lab Invest 60:161-8. 2000
    Ever since the coagulant activity of blood coagulation factor VII (FVII:C) was identified as a risk indicator of cardiac death, a large number of studies have measured FVII protein concentrations in plasma...
  42. ncbi Effects of dietary fat quality and quantity on postprandial activation of blood coagulation factor VII
    L F Larsen
    Research Department of Human Nutrition, Royal Veterinary and Agricultural University, Frederiksberg, Denmark
    Arterioscler Thromb Vasc Biol 17:2904-9. 1997
    Acute elevation of the coagulant activity of blood coagulation factor VII (FVIIc) is observed after consumption of high-fat meals. This elevation is caused by an increase in the concentration of activated FVII (FVIIa)...
  43. ncbi Boron supplementation and activated factor VII in healthy men
    J M W Wallace
    Northern Ireland Centre for Diet and Health, University of Ulster, Coleraine, Northern Ireland, UK
    Eur J Clin Nutr 56:1102-7. 2002
    The aim of the present study was to determine whether postprandial concentrations of the active component of serine protease coagulation factor VII (VIIa) were lowered by acute boron supplementation in vivo.
  44. ncbi A high fat meal activates blood coagulation factor VII in rats
    Aage K Olsen
    Department for Thrombosis Research, Ribe County Hospital, University of Southern Denmark, Esbjerg, Denmark
    J Nutr 132:347-50. 2002
    In humans, high fat meals cause postprandial activation of blood coagulation factor VII (FVII), but human studies have not provided definite evidence for a prothrombotic effect of dietary FVII activation...
  45. ncbi [Ectopic expression and clinical significance of tissue factor/coagulation factor VII complex in colorectal cancer]
    Jian Qiang Tang
    Department of General Surgery, Peking University First Hospital, Beijing 100034, China
    Beijing Da Xue Xue Bao 41:531-6. 2009
    To study the expression of coagulation factor VII(FVII)/tissue factor(TF)complex in colorectal carcinoma (CRC)and its correlation with clinicopathologic factor.
  46. ncbi The association of dietary fat and fiber with coagulation factor VII in the elderly: the Rotterdam Study
    L I Mennen
    Department of Epidemiology and Biostatistics, Erasmus University Rotterdam, Netherlands
    Am J Clin Nutr 65:732-6. 1997
    Considerable evidence suggests that a high concentration of coagulation factor VII is a risk factor for ischemic heart disease...
  47. ncbi [Coagulation factor VII levels in uremic patients and theirs influence factors]
    Jun Fang
    Institute of Hematology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 12:730-2. 2004
    This study was aimed to investigate coagulation factor VII level in uremic patients with chronic renal failure and to explore theirs influence factors...
  48. ncbi Calibration of human coagulation factor VII concentrate Ph. Eur. BRP batch 2
    J Dodt
    Paul Ehrlich Institut, D 63225 Langen, Germany
    Pharmeur Bio Sci Notes 2010:31-8. 2010
    The potency assay of human coagulation factor VII concentrate preparations as described in the European Pharmacopoeia (Ph. Eur.) requires a reference preparation calibrated in International Units (IU). The current Ph. Eur...
  49. ncbi Genetic effects for plasma factor VII levels independent of and in common with triglycerides
    Y Hong
    Division of Cardiovascular and Genetic Epidemiology, Institute of Environmental Medicine, The Karolinska Institute, Stockholm, Sweden
    Thromb Haemost 81:382-6. 1999
    b>Coagulation factor VII has been demonstrated as a potential risk factor for cardiovascular disease. Both genes and non-genetic factors are related to plasma levels of factor VII...
  50. ncbi Angiotensin-converting enzyme insertion/deletion genotype is associated with the activities of plasma coagulation factor VII and X independent of triglyceride metabolism
    Yoshifumi Okura
    Division of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan
    Coron Artery Dis 14:285-91. 2003
    ....
  51. ncbi The use of recombinant activated coagulation factor VII for spine surgery
    Richard B Weiskopf
    Department of Anesthesia and Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143 0648, USA
    Eur Spine J 13:S83-8. 2004
    This article focuses on our current understanding of the role of activated coagulation factor VII (FVIIa) in coagulation, the current evidence regarding the efficacy and safety of recombinant FVIIa (rFVIIa), and thoughts regarding the use ..
  52. ncbi Coagulation factor VII in middle-aged women with and without coronary heart disease
    M Eriksson-Berg
    King Gustaf V Research Institute Department of Medicine, Karolinska Hospital, Stockholm, Sweden
    Thromb Haemost 85:787-92. 2001
    Epidemiological studies of coagulation factor VII as a risk factor for coronary heart disease (CHD), mainly conducted in men, have shown discrepant results...
  53. ncbi Nucleotide structure and characterization of the murine blood coagulation factor VII gene
    E Idusogie
    Department of Chemistry and Biochemistry, University of Notre Dame, IN 46556, USA
    Thromb Haemost 76:957-64. 1996
    The gene encoding murine coagulation factor VII (fVII) has been cloned. Seven introns and eight exons are present, with the introns positioned as splice junctions between the major domain units of the protein...
  54. ncbi Combined factor VII/protein C deficiency results in intrauterine coagulopathy in mice
    J C Chan
    W M Keck Center for Transgene Research and the Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, USA
    J Clin Invest 105:897-903. 2000
    To determine whether an additional loss of the coagulation factor VII (FVII) gene influenced the coagulopathy observed in protein C gene-deficient (PC(-/-)) embryos and neonates, we crossed mice doubly heterozygous for the factor VII (..
  55. ncbi Expression and purification of recombinant human coagulation factor VII fused to a histidine tag using Gateway technology
    Raheleh Halabian
    Research Centre, Iranian Blood Transfusion Organisation, Tehran, Iran
    Blood Transfus 7:305-12. 2009
    ..The aim of this study was to construct, express and purify recombinant FVII fused to a polyhistidine (his) tag using Gateway technology...
  56. ncbi Factor VII-activating protease in patients with acute deep venous thrombosis
    Johannes J Sidelmann
    Institute of Public Health, University of Southern Denmark, Niels Bohrs Vej 9, DK 6700 Esbjerg, Denmark
    Thromb Res 122:848-53. 2008
    ..of a FSAP variant with reduced ability to activate scu-PA, without affecting the ability to activate coagulation Factor VII (FVII)...
  57. ncbi Effect of locally-applied active site-blocked activated factor VII (ASIS) on experimental arterial thrombosis
    B Arnljots
    Department of Plastic and Reconstructive Surgery, The University Hospital, Malmo, Sweden
    Blood Coagul Fibrinolysis 11:S145-8. 2000
    ..between tissue factor (TF), which is exposed following vascular disease or trauma, and activated blood coagulation factor VII (FVIIa)...
  58. ncbi The link between high-fat meals and postprandial activation of blood coagulation factor VII possibly involves kallikrein
    L F Larsen
    Research Department of Human Nutrition and Center for Advanced Food Studies, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark
    Scand J Clin Lab Invest 60:45-54. 2000
    ..Our findings indicate that triglyceride-rich lipoproteins activate prokallikrein postprandially, which might form an important initial event in FVII activation after consumption of high-fat meals...
  59. ncbi Plasma coagulation factor VII activity and its correlates in healthy men
    D Li
    Department of Food Science and Nutrition, Zhejiang University, Hangzhou, China
    Eur J Clin Nutr 59:1423-8. 2005
    The aim of this study was to investigate the plasma coagulation factor VII activity and its correlates in healthy Australian men.
  60. ncbi Cloning and expression of rat coagulation factor VII
    Shobha Seetharam
    Cardiovacular Department, The Bristol Myers Squibb Company, P O BOX 400, Experimental Station, Wilmington, DE 19880, USA
    Thromb Res 109:225-31. 2003
    ..Recombinant rat FVII may be an important new tool in the development of novel antithrombotic drugs...
  61. ncbi Contribution of factor VII genotype to activated FVII levels. Differences in genotype frequencies between northern and southern European populations
    F Bernardi
    Dipartimento di Biochimica e Biologia Molecolare, Universita degli Studi di Ferrara, Italy
    Arterioscler Thromb Vasc Biol 17:2548-53. 1997
    The relationship between coagulation factor VII (FVII) levels in plasma and FVII genotypes, determined by three polymorphisms (5'F7, IVS7, and 353R/Q), were studied in 500 control subjects enrolled in European multicenter study...
  62. ncbi In vitro effects of heparin and tissue factor pathway inhibitor on factor VII assays. possible implications for measurements in vivo after heparin therapy
    E M Bladbjerg
    Department of Thrombosis Research, University of Southern Denmark, Ribe County Hospital in Esbjerg
    Blood Coagul Fibrinolysis 11:739-45. 2000
    The coagulant activity of blood coagulation factor VII (FVII:C) can be lowered by changes in lifestyle and by therapeutic intervention, e.g. heparin infusion...
  63. ncbi Association of coagulation factor VII with the risk of myocardial infarction in the Chinese
    Q Cai
    Division of Coronary Heart Disease, Cardiovascular Institute, Fuwai Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100037, China
    Chin Med J (Engl) 113:1059-63. 2000
    ..To elucidate the association of plasma factor VII coagulant activity (FVIIc) with the risk of myocardial infarction (MI) and to assess the influence of factor VII gene MspI polymorphism and lipid metabolism on FVIIc in the Chinese...
  64. ncbi Extracellular RNA is a natural cofactor for the (auto-)activation of Factor VII-activating protease (FSAP)
    Fumie Nakazawa
    Graduate School of Allied Health Sciences, Tokyo Medical and Dental University, Bunkyo ku, Tokyo 113 8519, Japan
    Biochem J 385:831-8. 2005
    ..a new plasma-derived serine protease with putative dual functions in haemostasis, including activation of coagulation Factor VII and generation of urinary-type plasminogen activator (urokinase)...
  65. ncbi Are olive oil diets antithrombotic? Diets enriched with olive, rapeseed, or sunflower oil affect postprandial factor VII differently
    L F Larsen
    Research Department of Human Nutrition and Centre for Advanced Food Studies, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark
    Am J Clin Nutr 70:976-82. 1999
    ..A favorable effect of a high intake of olive oil on thrombogenesis may have contributed to this finding...
  66. ncbi Postprandial factor VII metabolism: the effect of the R353Q and 10 bp polymorphisms
    H M Roche
    Department of Clinical Medicine, Trinity Centre for Health Sciences, St James s Hospital, Dublin, Republic of Ireland
    Br J Nutr 83:467-72. 2000
    Elevated levels of coagulation factor VII activity (FVIIc) are associated with increased risk of CHD. FVIIc is strongly determined by two polymorphisms (R353Q and 0/10 base pairs (bp)) and plasma triacylglycerol (TAG) concentrations...
  67. ncbi Factor VII C329R: a variant with a disrupted disulfide bond in the catalytic domain
    H L James
    Department of Biochemistry, The University of Texas Health Center at Tyler, 75710, USA
    Blood Coagul Fibrinolysis 8:308-10. 1997
    We report a novel mutation within the coagulation factor VII gene associated with a dysfunctional procoagulant factor VII (12% of normal plasma factor VII activity; 50% of normal plasma factor VII antigen level)...
  68. ncbi Recombinant factor VIIa (Eptacog Alfa): a review of its use in congenital or acquired haemophilia and other congenital bleeding disorders
    M Asif A Siddiqui
    Adis International Limited, Auckland, New Zealand
    Drugs 65:1161-77. 2005
    Recombinant factor VIIa (NovoSeven) [also known as recombinant activated factor VII or eptacog alfa] is a vitamin K-dependent glycoprotein that is structurally similar to human plasma-derived factor VIIa...
  69. ncbi Recombinant factor VIIa (eptacog alfa): a pharmacoeconomic review of its use in haemophilia in patients with inhibitors to clotting factors VIII or IX
    Katherine A Lyseng-Williamson
    Wolters Kluwer Health Adis, Auckland, New Zealand
    Pharmacoeconomics 25:1007-29. 2007
    Recombinant factor VIIa (NovoSeven; also known as recombinant activated factor VII or eptacog alfa) is indicated as an intravenous haemostatic agent in haemophilia patients with inhibitors to clotting factors VIII or IX...
  70. ncbi An evaluation of eptacog alfa in nonhaemophiliac conditions
    Gordon Mallarkey
    New South Wales Therapeutic Advisory Group Inc, Darlinghurst, New South Wales, Australia
    Drugs 68:1665-89. 2008
    We have analysed the published literature on eptacog alfa (recombinant factor VIIa; rFVIIa) for nonhaemophiliac conditions with the aim of determining its current place in therapy...
  71. ncbi Clinical utilization of the international normalized ratio (INR)
    R S Riley
    Department of Pathology, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298 0250, USA
    J Clin Lab Anal 14:101-14. 2000
    ..in the sensitivity of different commercial sources and different lots of thromboplastin to blood coagulation factor VII. The INR is used worldwide by most laboratories performing oral anticoagulation monitoring, and is ..
  72. ncbi Liver after hepatocyte transplantation for liver-based metabolic disorders in children
    Alberto Quaglia
    Institute of Liver Studies, King s College Hospital and King s College London School of Medicine, London, UK
    Cell Transplant 17:1403-14. 2008
    ..explant livers of seven children with metabolic disorders [ornithine-transcarbamylase deficiency (one), coagulation factor VII deficiency (three), Crigler-Najjar syndrome (one), progressive familial intrahepatic cholestasis type 2 (..
  73. ncbi Hepatocyte transplantation for inherited factor VII deficiency
    Anil Dhawan
    Institute of Liver Studies, Guy s, King s, and St Thomas School of Medicine, and King s College Hospital, Denmark Hill, London, UK
    Transplantation 78:1812-4. 2004
    ..We report the first use of hepatocyte transplantation in two brothers with severe inherited coagulation factor VII deficiency. Patient 1 received a total of 1.09x10(9) cryopreserved hepatocytes, and patient received 2...
  74. ncbi Gene targeting of tissue factor, factor X, and factor VII in mice: their involvement in embryonic development
    M Aasrum
    Biotechnology Center of Oslo, P O B 1125 Blindern, N 0317 Oslo, Norway
    Biochemistry (Mosc) 67:25-32. 2002
    ..factor (TF) is the main initiator of the coagulation system and functions as a cell surface receptor for coagulation factor VII (FVII). Knockout studies have shown that TF deficiency results in lethality around embryonic day (E) 8...
  75. ncbi [The value of coagulation factors in severity categorization of hepatitis B-related liver cirrhosis]
    Qin Li
    Liver Research Center, Beijing Friendship Hospital, Capital University of Medical Sciences, Beijing 100050, China
    Zhonghua Nei Ke Za Zhi 44:188-90. 2005
    ..To investigate the diagnostic value of coagulation factors in assessing the severity degree of liver cirrhosis caused by hepatitis B...
  76. ncbi Low-density lipoprotein apheresis and changes in plasma components
    S Kojima
    Department of Clinical Research, Tohsei National Hospital, Sunto gun, Shizuoka, Japan
    Ther Apher 5:232-8. 2001
    ..factor XII, high-molecular-weight kininogen and prekallikrein); factors with lipophilic characteristics (coagulation factor VII, coagulation factor VIII, and vitamin E); and proteins with adhesive or other characteristics (von ..
  77. ncbi A benefit-risk review of systemic haemostatic agents: part 1: in major surgery
    Ian S Fraser
    Department of Obstetrics and Gynaecology, University of Sydney, Sydney, New South Wales, Australia
    Drug Saf 31:217-30. 2008
    ..b>Eptacog alfa (recombinant factor VIIa) has also shown promise...
  78. ncbi Expression of MRP2 and MRP3 during liver regeneration after 90% partial hepatectomy in rats
    Tung Huei Chang
    Second Department of Surgery, Hirosaki University School of Medicine, Hirosaki, Japan
    Transplantation 77:22-7. 2004
    ..The aim of this study was to research whether there is any change in bilirubin excretion pattern during liver regeneration with reference to expression of MRP2 and MRP3...
  79. ncbi [Study on proteomics of Jurkat cells treated with the extracts from Prunella vulgaris]
    Ming Zhi Zhang
    Department of Medical Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
    Zhong Yao Cai 32:917-22. 2009
    ..To analyse the differential proteins of Jurkat cells after treated with the extracts from Prunella vulgaris using two-dimensional electrophoresis and mass spectrum...
  80. ncbi Pharmacological strategies to decrease transfusion requirements in patients undergoing surgery
    Robert J Porte
    Department of Surgery, Section of Hepatobiliary Surgery and Liver Transplantation, University Medical Center Groningen, Groningen, The Netherlands
    Drugs 62:2193-211. 2002
    ..Novel drugs, like recombinant factor VIIa (eptacog alfa), are currently under clinical investigation...
  81. ncbi The effects of aspirin and nonselective beta blockade on the acute prothrombotic response to psychosocial stress in apparently healthy subjects
    Roland von Kanel
    Department of General Internal Medicine, University Hospital Berne, Switzerland
    J Cardiovasc Pharmacol 51:231-8. 2008
    ..Plasma levels of von Willebrand factor antigen (VWF:Ag), fibrinogen, coagulation factor VII (FVII:C) and XII (FXII:C) activity, and D-dimer were determined in blood samples collected immediately pre-..
  82. ncbi Recombinant factor VIIa reduces bleeding in severely thrombocytopenic rabbits
    Mikael Tranholm
    Pharmacology Research 5, Pharmacology Research and Development, Novo Nordisk A S, Novo Nordisk Park, DK 2760 Maaloev, Denmark
    Thromb Res 109:217-23. 2003
    ..To test the efficacy of recombinant activated human coagulation factor VII (rFVIIa, NovoSeven) in thrombocytopenia, a preclinical study was conducted in thrombocytopenic rabbits...
  83. ncbi [A Jehovah's Witness child with hemophilia B and factor IX inhibitors undergoing scoliosis surgery]
    Anthony Chau
    Faculty of Medicine, University of British Columbia, British Columbia Children s Hospital, Vancouver, British Columbia, Canada
    Can J Anaesth 55:47-51. 2008
    ..To describe the successful perioperative hemostatic management of a Jehovah's Witness patient with hemophilia B and anaphylactic inhibitors to factor IX, undergoing scoliosis surgery...
  84. ncbi The Mediterranean Sea as a barrier to gene flow: evidence from variation in and around the F7 and F12 genomic regions
    Georgios Athanasiadis
    Unitat d Antropologia, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
    BMC Evol Biol 10:84. 2010
    ..Analyses were carried out on a diverse set of neutral and functional polymorphisms located in and around the coagulation factor VII and XII genomic regions (F7 and F12).
  85. ncbi Pharmacokinetics, distribution, and excretion of 125I-labeled human plasma-derived-FVIIa and -FX with MC710 (FVIIa/FX mixture) in rats
    Yasushi Nakatomi
    Therapeutic Protein Product Research Department, The Chemo Sero Therapeutic Research Institute, Kaketsuken, Kumamoto, Japan
    Thromb Res 129:62-7. 2012
    ..The pharmacokinetics, distribution, and excretion of (125)I-labeled-FVIIa ((125)I-FVIIa) and -FX ((125)I-FX) were studied in male rats after a single intravenous administration of (125)I-FVIIa or (125)I-FX combined with MC710...
  86. ncbi TF/FVIIa transactivate PDGFRbeta to regulate PDGF-BB-induced chemotaxis in different cell types: involvement of Src and PLC
    Agneta Siegbahn
    Department of Medical Sciences, Clinical Chemistry, Academic Hospital, SE 751 85 Uppsala, Sweden
    Arterioscler Thromb Vasc Biol 28:135-41. 2008
    ..Here we studied the role of TF/FVIIa and the induced signaling pathways in regulation of chemotaxis of human monocytes, fibroblasts, and porcine aorta endothelial cells...
  87. ncbi The effect of nine common polymorphisms in coagulation factor genes (F2, F5, F7, F12 and F13 ) on the effectiveness of statins: the GenHAT study
    Anke Hilse Maitland-van der Zee
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht University, Utrecht, The Netherlands
    Pharmacogenet Genomics 19:338-44. 2009
    ..Statins have been shown to influence the expression of coagulation factors II, V, VII, XII and XIII...
  88. ncbi A two adenine insertion polymorphism in the 3' untranslated region of factor VII gene is associated with peripheral arterial disease but not with venous thrombosis. Results of case-control studies
    Emilie Serve
    INSERM, Unité 765, Paris, France
    Thromb Haemost 98:733-7. 2007
    ..24 [95% CI 0.06-0.99]. In conclusion, the 2 adenine insertion in the 3'UTR of FVII gene, related to lower plasma FVII levels, is a genetic variation that may contribute to reduce the risk of PAD...
  89. ncbi Coagulation factor VII and the risk of coronary heart disease in healthy men
    R Junker
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Westfalische Wilhelms Universitat Munster, Germany
    Arterioscler Thromb Vasc Biol 17:1539-44. 1997
    ..A tendency to thrombosis may also be indicated by elevated levels of coagulation factor VII clotting activity (FVIIc)...
  90. ncbi Gene polymorphisms implicated in influencing susceptibility to venous and arterial thromboembolism: frequency distribution in a healthy German population
    Berthold Hoppe
    Institute of Transfusion Medicine, Campus Benjamin Franklin, Charité Universitätsklinikum Berlin, Berlin, Germany
    Thromb Haemost 96:465-70. 2006
    ....
  91. ncbi Linear analogues derived from the first EGF-like domain of human blood coagulation factor VII: enhanced inhibition of FVIIa/TF complex activity by backbone modification through aspartimide formation
    M Husbyn
    Nycomed Imaging, Bioreg Research, Oslo, Norway
    J Pept Sci 5:323-9. 1999
    b>Coagulation factor VII bound to its cofactor tissue factor is the physiological initiator of blood coagulation...
  92. ncbi Site-directed mutagenesis but not gamma-carboxylation of Glu-35 in factor VIIa affects the association with tissue factor
    E Persson
    Vessel Wall Biology, Health Care Discovery, Novo Nordisk AIS, Gentofte, Denmark
    FEBS Lett 385:241-3. 1996
    ..In contrast, Glu or Gla side chains at position 35 appear to fulfil the functional roles equally well...
  93. ncbi Regulation of coagulation by a multivalent Kunitz-type inhibitor
    G J Broze
    Jewish Hospital, Washington University Medical Center, St. Louis, Missouri 63110
    Biochemistry 29:7539-46. 1990
  94. ncbi [Iatrogenic injuries of the pulmonary artery]
    P Hromadka
    Chirurgické Oddeleni, Krajská Nemocnice Liberec
    Rozhl Chir 89:234-6. 2010
    ..the outcome for the patient is thank to early surgical treatment (the application of recombinant coagulation factor VII - Novoseven, blood recuperation, therapeutic hypothermia) and professional postoperative care maximally ..
  95. ncbi Association of ACE and FACTOR VII gene variability with the risk of coronary heart disease in north Indian population
    R C Sobti
    Department of Biotechnology, Panjab University, Chandigarh 160014, India
    Mol Cell Biochem 341:87-98. 2010
    ..18, 95% CI 0.09-0.36, P < 0.001. Our study showed D allele of ACE to be associated with marginal risk of CHD, AA genotype of FACTOR VII R353Q and H6H7 and H7H7 genotypes of FACTOR VII VNTR showed protective effect for CHD...
  96. ncbi Consensus protocol for the use of recombinant activated factor VII [eptacog alfa (activated); NovoSeven] in elective orthopaedic surgery in haemophilic patients with inhibitors
    P L F Giangrande
    Oxford Haemophilia and Thrombosis Centre, Churchill Hospital, UK
    Haemophilia 15:501-8. 2009
    ..Although the initial cost of product to cover surgery such as arthroplasty is high, it needs to be borne in mind that this may be offset in subsequent years by savings resulting from avoidance of bleeding episodes in the affected joint...
  97. ncbi Self-production of tissue factor-coagulation factor VII complex by ovarian cancer cells
    N Yokota
    Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, 1 1 2 Nakao Asahi ku, 241 0815 Yokohama, Japan
    Br J Cancer 101:2023-9. 2009
    ..TF binds to coagulation factor VII (fVII), changing it to its active form, fVIIa...
  98. ncbi Common polymorphisms and cardiovascular factors in patients with myocardial infarction of Costa Rica
    Lizbeth Salazar-Sanchez
    Centro de Investigacion en Hematología y Trastornos Afines, CIHATA Universidad de Costa Rica, Hospital San Juan de Dios, 10634 1000 San José, Costa Rica
    Rev Biol Trop 54:1-11. 2006
    ..This is one of the first reports in a Latin-American population dealing with these molecular markers and MI...
  99. ncbi A missense mutation (178Cys-->Tyr) and two neutral dimorphisms (115His and 333Ser) in the human coagulation factor VII gene
    G Marchetti
    Centro Studi Biochimici delle Patologie del Genoma Umano, , Italy
    Hum Mol Genet 2:1055-6. 1993
  100. ncbi Orphan nuclear receptor HNF-4 binds to the human coagulation factor VII promoter
    D Erdmann
    Ciba Geigy AG, Core Drug Discovery Technologies, Basle, Switzerland
    J Biol Chem 270:22988-96. 1995
    ..Coordinate HNF-4-mediated regulation of several blood protease genes as well as genes involved in lipid metabolism might account for the positive correlation of these factors with increased risk of occlusive heart diseases...
  101. ncbi Current status on tissue factor activation of factor VIIa
    Egon Persson
    Haemostasis Biochemistry, Novo Nordisk A S, Måløv, Denmark
    Thromb Res 125:S11-2. 2010
    ..The present paper is a brief compilation of our current knowledge of the allosteric mechanism by which tissue factor induces and stabilizes the active conformation of factor VIIa...

Research Grants66

  1. INITIATION AND REGULATION OF BLOOD COAGULATION
    VIJAYA MOHAN RAO LELLA; Fiscal Year: 2010
    The coagulation cascade is initiated by binding of the coagulation factor VII(a) (FVIIa) to its cell surface receptor, tissue factor (TF)...
  2. INITIATION AND REGULATION OF BLOOD COAGULATION
    VIJAYA LELLA; Fiscal Year: 2007
    The coagulation cascade is initiated by the binding of coagulation factor VII(a) to its cell surface receptor tissue factor (TF)...
  3. Cardiovascular Disease Epidemiology & Prevention Trng
    Aaron Folsom; Fiscal Year: 2007
    ..The continued need for qualified cardiovascular epidemiologists and the program's documented success justify its continuance. ..
  4. Gene and Nutrient Etiologies of Human Heart Defects
    Gary Shaw; Fiscal Year: 2007
    ..Because these defects result in substantial morbidity as well as high emotional and economic costs, further scientific understanding leading to possible prevention would greatly benefit society. ..
  5. New York-Presbyterian NETT Consortium
    Stephan Mayer; Fiscal Year: 2007
    ....
  6. PHILA-NETT: Neurological Emergencies Treatment Trials (NETT) Network Clinical Sit
    NINA GENTILE; Fiscal Year: 2007
    ..In addition Phila-NETT's community education component will focus on primary and secondary disease prevention with the hope of decreasing the incidence of acute neurological emergencies. ..
  7. Fat Induced Insulin Resistance and Atherosclerosis
    Guenther Boden; Fiscal Year: 2007
    ..We believe that these studies will provide important new information relative to the mechanism by which obesity and FFAs cause IR and ASVD in human subjects. ..
  8. Hyperglycemia and Hyperinsulinemia Induced Procoagulant State
    Guenther Boden; Fiscal Year: 2010
    ....
  9. Estrogens and pharmacogenetic risks of venous thrombosis in postmenopausal women
    Nicholas L Smith; Fiscal Year: 2010
    ..We propose an extension of our population-based, case-control study in post-menopausal women to examine risks of venous thrombosis associated with oral estradiol and other estrogens. ..
  10. Pharmacologic and pharmacogenetic associations with recurrent venous thrombosis
    Nicholas L Smith; Fiscal Year: 2010
    ..abstract_text> ..
  11. Hyperglycemia and Hyperinsulinemia Induced Procoagulant State
    Guenther Boden; Fiscal Year: 2010
    ....
  12. Thrombosis Genetics, MI and Stroke in Older Adults
    Alexander P Reiner; Fiscal Year: 2010
    ....
  13. Tissue Factor-factor Vlla signaling
    Usha Pendurthi; Fiscal Year: 2010
    ..The proposed studies will provide valuable information in understanding how TF contributes to tumorigenesis. These studies will also provide clues on potential therapeutic targets for prevention of cancer progression. ..
  14. Clotting genetic variant, hormones and venous thrombosis
    Nicholas Smith; Fiscal Year: 2007
    ....
  15. Procoagulants in Aging CARDIA Participants
    David Green; Fiscal Year: 2007
    ....
  16. FAT MEDIATED INSULIN SECRETION AND DIABETES IN ELDERLY
    Guenther Boden; Fiscal Year: 2003
    ..We hope that this project will help to better understand the mechanisms by which obesity contributes to the development of NIDDM. ..
  17. Cyr61 and CTGF: Mediators of Factor VIIa signaling
    Usha Pendurthi; Fiscal Year: 2004
    ....
  18. Tissue Factor-factor Vlla signaling
    Usha Pendurthi; Fiscal Year: 2007
    ..The proposed studies will provide valuable information in understanding how TF contributes to tumorigenesis. These studies will also provide clues on potential therapeutic targets for prevention of cancer progression. ..
  19. Free Fatty Acids and Hepatic Insulin Resistance
    Guenther Boden; Fiscal Year: 2007
    ..These studies will hopefully provide much needed information relative to important details and mechanisms of FFA induced hepatic insulin resistance. ..
  20. ANTIOXIDANT & HYPERGLYCEMIA INDUCED PROCOAGULANT STATE
    Guenther Boden; Fiscal Year: 2005
    ....
  21. Molecular Epidemiology of MI and Stroke in Older Adults
    Alexander Reiner; Fiscal Year: 2006
    ....