F13B

Summary

Gene Symbol: F13B
Description: coagulation factor XIII B chain
Alias: FXIIIB, coagulation factor XIII B chain, TGase, coagulation factor XIII, B polypeptide, fibrin-stabilizing factor B subunit, protein-glutamine gamma-glutamyltransferase B chain, transglutaminase B chain
Species: human
Products:     F13B

Top Publications

  1. Saito M, Asakura H, Ito K, Okafuji K, Yoshida T, Matsuda T. A familial factor XIII subunit B deficiency. Br J Haematol. 1990;74:290-4 pubmed
    ..This is the first report of congenital deficiency of factor XIII subunit B and this disorder is thought to be inherited as an autosomal recessive trait. ..
  2. Hashiguchi T, Saito M, Morishita E, Matsuda T, Ichinose A. Two genetic defects in a patient with complete deficiency of the b-subunit for coagulation factor XIII. Blood. 1993;82:145-50 pubmed
    ..The replacement of guanosine-11499 by thymidine in their exon VIII has also been confirmed by sequence analysis, indicating that they are heterozygous for one normal and one defective allele. ..
  3. Reiner A, Heckbert S, Vos H, Ariens R, Lemaitre R, Smith N, et al. Genetic variants of coagulation factor XIII, postmenopausal estrogen therapy, and risk of nonfatal myocardial infarction. Blood. 2003;102:25-30 pubmed
    ..03). If confirmed, these findings may permit a better assessment of the cardiovascular risks and benefits associated with postmenopausal estrogen therapy. ..
  4. Komanasin N, Catto A, Futers T, Van Hylckama Vlieg A, Rosendaal F, Ariens R. A novel polymorphism in the factor XIII B-subunit (His95Arg): relationship to subunit dissociation and venous thrombosis. J Thromb Haemost. 2005;3:2487-96 pubmed
    ..To screen the FXIIIB gene coding region for common variation and analyze possible functional effects...
  5. Souri M, Kaetsu H, Ichinose A. Sushi domains in the B subunit of factor XIII responsible for oligomer assembly. Biochemistry. 2008;47:8656-64 pubmed publisher
    ..The present studies, however, do not exclude the possibility that additional Sushi domains may also support either or both functions. ..
  6. Guo H, Xian J, Wang A. Analysis of digital gene expression profiling in hemocytes of white shrimp Litopenaeus vannamei under nitrite stress. Fish Shellfish Immunol. 2016;56:1-11 pubmed publisher
    ..C type lectin 4 (CTL4), protein disulfide isomerase (PDI), serine protease inhibitor 8 (SPI8), transglutaminase (TGase), chitinase1, inhibitors of apoptosis proteins (IAP) and cytochrome P450 enzyme (CYP450) were induced to ..
  7. Reyna Beltrán E, Iranzo M, Calderón González K, Mondragón Flores R, Labra Barrios M, Mormeneo S, et al. The Candida albicans ENO1 gene encodes a transglutaminase involved in growth, cell division, morphogenesis, and osmotic protection. J Biol Chem. 2018;293:4304-4323 pubmed publisher
    ..Finally, we identified enolase 1 as the cell wall protein responsible for TGase activity...
  8. Hong P, Ndagijimana M, Betti M. Glucosamine-induced glycation of hydrolysed meat proteins in the presence or absence of transglutaminase: Chemical modifications and taste-enhancing activity. Food Chem. 2016;197 Pt B:1143-52 pubmed publisher
    ..with glucosamine (GlcN) at moderate temperatures (37/50°C) in the presence or absence of transglutaminase (TGase)...
  9. Kim S, Park W, Park E, Park B, Joo J, Joung J, et al. The prognostic value of BAP1, PBRM1, pS6, PTEN, TGase2, PD-L1, CA9, PSMA, and Ki-67 tissue markers in localized renal cell carcinoma: A retrospective study of tissue microarrays using immunohistochemistry. PLoS ONE. 2017;12:e0179610 pubmed publisher
    ..63) and RFS (HR, 8.51) in the multivariable model (p<0.05). pS6 and Ki-67 are significant prognostic factors of RCC; however, BAP1, PBRM1, TGase 2, PD-L1, CA9, PTEN loss, and PSMA markers did not show this association.

More Information

Publications153 found, 100 shown here

  1. Sánchez Ortiz A, Angulo C, Luna González A, Alvarez Ruiz P, Mazón Suastegui J, Campa Córdova A. Effect of mixed-Bacillus spp isolated from pustulose ark Anadara tuberculosa on growth, survival, viral prevalence and immune-related gene expression in shrimp Litopenaeus vannamei. Fish Shellfish Immunol. 2016;59:95-102 pubmed publisher
    ..the mRNA expression of the Hsp70 gene was down-regulated in treatments T4 and T5 respect to control, and the TGase gene remained unaffected by the level of bacillus probiotic mix...
  2. Zhang P, Hu T, Feng S, Xu Q, Zheng T, Zhou M, et al. Effect of high intensity ultrasound on transglutaminase-catalyzed soy protein isolate cold set gel. Ultrason Sonochem. 2016;29:380-7 pubmed publisher
    ..In conclusion, HIU changed physicochemical and structural properties of SPI, producing better substrates for TGase. The resulting TSCG network structure was formed with greater involvement of covalent and non-covalent ..
  3. Giordano D, Facchiano A. Classification of microbial transglutaminases by evaluation of evolution trees, sequence motifs, secondary structure topology and conservation of potential catalytic residues. Biochem Biophys Res Commun. 2019;509:506-513 pubmed publisher
    ..a classification of microbial TGases, starting from large-scale analysis of all protein sequences annotated as TGase (more than 8000) in database PFAM...
  4. Kim S, Park B, Joo J, Joung J, Seo H, Lee K, et al. Retrospective analysis of 25 immunohistochemical tissue markers for differentiating multilocular cystic renal neoplasm of low malignant potential and multicystic renal cell carcinoma. Histol Histopathol. 2018;33:589-596 pubmed publisher
    ..Among the 25 tissue markers, only HIF1a, PDGFR?, SMA, VEGFR1, VEGFR2, VEGFR3, CD10, CD31, CD34, CK7-tubule, TGAse-2, and Ki-67 showed significantly different expression between the groups...
  5. Hu Q, Yi L, Chen K, Zhou J, Chen L, Zeng L, et al. [Analysis of clinical phenotype and TGM1 gene mutation in a child with neonatal congenital ichthyosis]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2019;36:357-359 pubmed publisher
    ..By bioinformatic analysis, both mutations are likely to impair the function of TGase-1 protein. The compound heterozygous mutations of c.327delG and c...
  6. Chen K, Lin C, Guo C, Chang Y, Hu C, Lin H, et al. Effect of the lipid II sugar moiety on bacterial transglycosylase: the 4-hydroxy epimer of lipid II is a TGase inhibitor. Chem Commun (Camb). 2017;53:771-774 pubmed publisher
    ..Unexpectedly, N-deacetyled lipid II decreased its activity dramatically, and the C4-axial OH lipid II became an inhibitor (IC50 = 8 μM) with an approximately 14-fold increase in binding affinity toward TGase (25 vs. 27).
  7. Hasegawa T, Shimada H, Uchiyama T, Ueda O, Nakashima M, Matsuoka Y. Dietary glucosylceramide enhances cornified envelope formation via transglutaminase expression and involucrin production. Lipids. 2011;46:529-35 pubmed publisher
    ..The GlcCer treatment also increased the level of TGase-1 mRNA in UVB-irradiated murine epidermis approximately 1.6-fold compared with the control...
  8. Singh S, Akhter M, Dodt J, Sharma A, Kaniyappan S, Yadegari H, et al. Disruption of Structural Disulfides of Coagulation FXIII-B Subunit; Functional Implications for a Rare Bleeding Disorder. Int J Mol Sci. 2019;20: pubmed publisher
    Congenital FXIII deficiency is a rare bleeding disorder in which mutations are detected in F13A1 and F13B genes that express the two subunits of coagulation FXIII, the catalytic FXIII-A, and protective FXIII-B...
  9. Zhang M, Wang P, Zou M, Yang R, Tian M, Gu Z. Microbial transglutaminase-modified protein network and its importance in enhancing the quality of high-fiber tofu with okara. Food Chem. 2019;289:169-176 pubmed publisher
    ..Current results showed that microbial transglutaminase (TGase) remarkably enhanced the gel strength, water holding capacity and viscoelasticity of HFT...
  10. Li C, Xiong Y. Disruption of secondary structure by oxidative stress alters the cross-linking pattern of myosin by microbial transglutaminase. Meat Sci. 2015;108:97-105 pubmed publisher
    ..was oxidatively stressed in an iron-H2O2 radical-producing system then subjected to microbial transglutaminase (TGase, E:S=1:20) at 4°C...
  11. Yuan F, Lv L, Li Z, Mi N, Chen H, Lin H. Effect of transglutaminase-catalyzed glycosylation on the allergenicity and conformational structure of shrimp (Metapenaeus ensis) tropomyosin. Food Chem. 2017;219:215-222 pubmed publisher
    ..The aim of this study was to evaluate the effect of transglutaminase (TGase)-catalyzed glycosylation on the potential allergenicity and conformational structure of TM in Metapenaeus ensis...
  12. Gong P, Di W, Yi H, Sun J, Zhang L, Han X. Improved viability of spray-dried Lactobacillus bulgaricus sp1.1 embedded in acidic-basic proteins treated with transglutaminase. Food Chem. 2019;281:204-212 pubmed publisher
    ..Transglutaminase (TGase)-induced cross-linking then tightened the cell-protein complexes...
  13. Shi J, Zhao X. Effect of caseinate glycation with oligochitosan and transglutaminase on the intestinal barrier function of the tryptic caseinate digest in IEC-6 cells. Food Funct. 2019;10:652-664 pubmed publisher
    ..Oligochitosan was used in this study to glycate commercial caseinate under the catalytic action of transglutaminase (TGase), followed by trypsin-mediated digestion...
  14. Gemmati D, Occhionorelli S, Tisato V, Vigliano M, Longo G, Gonelli A, et al. Inherited genetic predispositions in F13A1 and F13B genes predict abdominal adhesion formation: identification of gender prognostic indicators. Sci Rep. 2018;8:16916 pubmed publisher
    ..54%,♀), were PCR-SNP-genotyped for FXIIIA V34L (rs5985), FXIIIA P564L (rs5982), FXIIIA Y204F (rs3024477) and FXIIIB H95R (rs6003). Patients' clinical phenotypes were: Group-A (n = 212), those who developed AA, and 55...
  15. Mattinen M, Rivière G, Henn A, Nugroho R, Leskinen T, Nivala O, et al. Colloidal Lignin Particles as Adhesives for Soft Materials. Nanomaterials (Basel). 2018;8: pubmed publisher
    ..NPs ca. 300 nm were prepared, β-casein coated and cross-linked with transglutaminase (Tgase) to agglutinate chamois...
  16. Del Duca S, Aloisi I, Parrotta L, Cai G. Cytoskeleton, Transglutaminase and Gametophytic Self-Incompatibility in the Malinae (Rosaceae). Int J Mol Sci. 2019;20: pubmed publisher
    ..production of reactive oxygen species (ROS) and altered enzymatic activities, such as that of transglutaminase (TGase)...
  17. Rosenthal A, Gohr C, Mitton E, Monnier V, Burner T. Advanced glycation end products increase transglutaminase activity in primary porcine tenocytes. J Investig Med. 2009;57:460-6 pubmed publisher
    ..However, cellular effects of AGEs, such as increased activity of the cross-linking transglutaminase (Tgase) enzymes, could also contribute to altered tissue biomechanics and calcification in diabetic tendons...
  18. Rogers D, Baldini F, Battaglia F, Panico M, Dell A, Morris H, et al. Transglutaminase-mediated semen coagulation controls sperm storage in the malaria mosquito. PLoS Biol. 2009;7:e1000272 pubmed publisher
    ..it is formed through the cross-linking of seminal proteins mediated by a MAG-specific transglutaminase (TGase), a mechanism remarkably similar to mammalian semen coagulation...
  19. Tahlan A, Ahluwalia J. Factor XIII: congenital deficiency factor XIII, acquired deficiency, factor XIII A-subunit, and factor XIII B-subunit. Arch Pathol Lab Med. 2014;138:278-81 pubmed publisher
    ..Factor XIII has a long half-life; therefore, the patients can lead near-normal lives with regular replacements. Patients with acquired FXIII deficiency with inhibitors need immunosuppressive therapy in addition to factor replacements. ..
  20. Spolaore B, Forzato G, Fontana A. Site-specific derivatization of human interferon β-1a at lysine residues using microbial transglutaminase. Amino Acids. 2018;50:923-932 pubmed publisher
    Microbial transglutaminase (TGase) has been successfully used to produce site-specific protein conjugates derivatized at the level of glutamine (Gln) or lysine (Lys) residues with diverse applications...
  21. Junkunlo K, Soderhall K, Söderhäll I. Transglutaminase inhibition stimulates hematopoiesis and reduces aggressive behavior of crayfish, Pacifastacus leniusculus. J Biol Chem. 2019;294:708-715 pubmed publisher
    Transglutaminase (TGase) is a Ca2+-dependent cross-linking enzyme, which has both enzymatic and nonenzymatic properties...
  22. Lee S, Lee W, Kim N, Kang J, Kim K, Kim S, et al. Renal Cell Carcinoma Is Abrogated by p53 Stabilization through Transglutaminase 2 Inhibition. Cancers (Basel). 2018;10: pubmed publisher
    In general, expression of transglutaminase 2 (TGase 2) is upregulated in renal cell carcinoma (RCC), resulting in p53 instability. Previous studies show that TGase 2 binds to p53 and transports it to the autophagosome...
  23. Wang J, Zou L, Yuan F, Lv L, Tian S, Li Z, et al. Inhibition of advanced glycation endproducts during fish sausage preparation by transglutaminase and chitosan oligosaccharides induced enzymatic glycosylation. Food Funct. 2018;9:253-262 pubmed publisher
    ..order to reduce the content of AGEs in foods, the inhibitory effect of different proportions of transglutaminase (TGase) and chitosan oligosaccharides (COS) on the AGEs of seabream fish meat sausage was studied...
  24. Yuan F, Ahmed I, Lv L, Li Z, Li Z, Lin H, et al. Impacts of glycation and transglutaminase-catalyzed glycosylation with glucosamine on the conformational structure and allergenicity of bovine ?-lactoglobulin. Food Funct. 2018;: pubmed publisher
    Lactoglobulin (?-LG) is recognized as the major milk allergen. In this study, the effects of transglutaminase (TGase) and glucosamine (GlcN)-catalyzed glycosylation and glycation on the conformational structure and allergenicity of ?-..
  25. Cheng S, Wang W, Li Y, GAO G, Zhang K, Zhou J, et al. Cross-linking and film-forming properties of transglutaminase-modified collagen fibers tailored by denaturation temperature. Food Chem. 2019;271:527-535 pubmed publisher
    Transglutaminase (TGase) catalyzing crosslinking between intra- and inter-chain glutamine and lysine peptide residues has been used for modifying protein's structure...
  26. Sobieszczuk Nowicka E, Zmienko A, Samelak Czajka A, Łuczak M, Pietrowska Borek M, Iorio R, et al. Dark-induced senescence of barley leaves involves activation of plastid transglutaminases. Amino Acids. 2015;47:825-38 pubmed publisher
    ..Using an anti-TGase antibody, we detected on a subcellular level, the ChlTGases that were associated with destacked/degraded thylakoid ..
  27. Lee Y, Jung S, Kim S, Kim M, Lee S, Hwang J, et al. Essential Role of Transglutaminase 2 in Vascular Endothelial Growth Factor-Induced Vascular Leakage in the Retina of Diabetic Mice. Diabetes. 2016;65:2414-28 pubmed publisher
    ..Here we designed an in vivo transglutaminase (TGase) activity assay in mouse retina and demonstrated that hyperglycemia induced vascular leakage by activating TGase2 ..
  28. Ablin R, Owen S, Jiang W. Prostate Transglutaminase (TGase-4) Induces Epithelial-to-Mesenchymal Transition in Prostate Cancer Cells. Anticancer Res. 2017;37:481-487 pubmed
    ..Our studies of transglutaminase-4 (TGase-4), a member of the TGase family, expressed in the prostate gland, have implicated it in the regulation of the ..
  29. Perdomo Morales R, Montero Alejo V, Perera E. The clotting system in decapod crustaceans: History, current knowledge and what we need to know beyond the models. Fish Shellfish Immunol. 2019;84:204-212 pubmed publisher
    ..of the plasmatic clotting protein (CP) which is directly promoted by calcium-depended transglutaminase (TGase) released from hemocytes upon microbial stimulus or injury...
  30. Chen L, Ullah N, Li C, Hackman R, Li Z, Xu X, et al. Incorporated glucosamine adversely affects the emulsifying properties of whey protein isolate polymerized by transglutaminase. J Dairy Sci. 2017;100:3413-3423 pubmed publisher
    Glucosamine (GlcN) and microbial transglutaminase (Tgase) are used separately or together to improve the emulsifying properties of whey protein isolate (WPI)...
  31. Cai X, Hu S, Yu B, Cai Y, Yang J, Li F, et al. Transglutaminase-catalyzed preparation of crosslinked carboxymethyl chitosan/carboxymethyl cellulose/collagen composite membrane for postsurgical peritoneal adhesion prevention. Carbohydr Polym. 2018;201:201-210 pubmed publisher
    ..In this work, a transglutaminase (TGase)-catalyzed crosslinked carboxymethyl chitosan/carboxymethyl cellulose/collagen (CMCS/CMCL/COL) composite anti-..
  32. Kim S. New Insights into Development of Transglutaminase 2 Inhibitors as Pharmaceutical Lead Compounds. Med Sci (Basel). 2018;6: pubmed publisher
    Transglutaminase 2 (EC 2.3.2.13; TG2 or TGase 2) plays important roles in the pathogenesis of many diseases, including cancers, neurodegeneration, and inflammatory disorders...
  33. Mezei Z, Bereczky Z, Katona Ã, Gindele R, Balogh E, Fiatal S, et al. Factor XIII B subunit polymorphisms and the risk of coronary artery disease. Int J Mol Sci. 2015;16:1143-59 pubmed publisher
    ..The F13B gene was genotyped for p...
  34. Kim N, Kang J, Lee W, Kim S, Lee J, Lee S, et al. Allosteric inhibition site of transglutaminase 2 is unveiled in the N terminus. Amino Acids. 2018;50:1583-1594 pubmed publisher
    Previously we have demonstrated transglutaminase 2 (TGase 2) inhibition abrogated renal cell carcinoma (RCC) using GK921 (3-(phenylethynyl)-2-(2-(pyridin-2-yl)ethoxy)pyrido[3,2-b]pyrazine), although the mechanism of TGase 2 inhibition ..
  35. De Filippis A, Perfetto B, Guerrera L, Oliviero G, Baroni A. Q-switched 1064 nm Nd-Yag nanosecond laser effects on skin barrier function and on molecular rejuvenation markers in keratinocyte-fibroblasts interaction. Lasers Med Sci. 2019;34:595-605 pubmed publisher
    ..Particularly, we evaluated the expression of filaggrin, TGase, HSP70, and aquaporins, on HaCaT cells. The expression of proinflammatory cytokines has been investigated too...
  36. Ivaskevicius V, Biswas A, Garly M, Oldenburg J. Comparison of F13A1 gene mutations in 73 patients treated with recombinant FXIII-A2. Haemophilia. 2017;23:e194-e203 pubmed publisher
    ..Ser296Arg) in combination with a novel, probably polymorphic variant of the F13B gene (p.Ser654Phe). Molecular modelling of five F13A1 novel missense mutations (p.Leu171Phe, p.Glu204Lys, p...
  37. Chen C, Okazaki E, Osako K. Textural improvement of salt-reduced Alaska pollack (Theragra chalcogramma) roe product by CaCl2. Food Chem. 2016;213:268-273 pubmed publisher
    ..contents, eggshell protein composition of the salted roe products, as well as total endogenous transglutaminase (TGase) activity in various NaCl and CaCl2 concentrations were analyzed...
  38. Jiang S, Zhang X, Ma Y, Tuo Y, Qian F, Fu W, et al. Characterization of whey protein-carboxymethylated chitosan composite films with and without transglutaminase treatment. Carbohydr Polym. 2016;153:153-159 pubmed publisher
    ..its functional properties, four types of WPC-CMC composite films were prepared with and without Transglutaminase (TGase) treatment by mixing WPC aqueous solutions (10%, w/v) with CMC aqueous solutions (3%, w/v) at WPC to CMC volume ..
  39. Weng W, Zheng H. Effect of transglutaminase on properties of tilapia scale gelatin films incorporated with soy protein isolate. Food Chem. 2015;169:255-60 pubmed publisher
    The effect of transglutaminase (TGase) on the properties of tilapia scale gelatin films in the presence of soy protein isolate (SPI) was investigated...
  40. Cao H, Fan D, Jiao X, Huang J, Zhao J, Yan B, et al. Intervention of transglutaminase in surimi gel under microwave irradiation. Food Chem. 2018;268:378-385 pubmed publisher
    Transglutaminase (TGase) was selected as model enzyme to investigate the effects of microwave (MW) heating on its activity and structure compared to water bath (WB) heating...
  41. Liu S, Wan D, Wang M, Madzak C, Du G, Chen J. Overproduction of pro-transglutaminase from Streptomyces hygroscopicus in Yarrowia lipolytica and its biochemical characterization. BMC Biotechnol. 2015;15:75 pubmed publisher
    Transglutaminases (TGase), synthesized as a zymogen (pro-TGase) in Streptomyces sp., are important enzymes in food industry...
  42. Salvarese N, Spolaore B, Marangoni S, Pasin A, Galenda A, Tamburini S, et al. Transglutaminase-mediated conjugation and nitride-technetium-99m labelling of a bis(thiosemicarbazone) bifunctional chelator. J Inorg Biochem. 2018;183:18-31 pubmed publisher
    An assessment study involving the use of the transglutaminase (TGase) conjugation method and the nitride-technetium-99m labelling on a bis(thiosemicarbazone) (BTS) bifunctional chelating agent is presented...
  43. Yang C, Lu C, Chen S, Liao W, Chen S. Immune gene expression for diverse haemocytes derived from pacific white shrimp, Litopenaeus vannamei. Fish Shellfish Immunol. 2015;44:265-71 pubmed publisher
    ..binding protein (LGBP), peroxinectin, crustin, lysozyme, penaeid-3a and transglutaminase (TGase), expressed from different haemocyte were analysed by quantitative real time PCR (qPCR)...
  44. Zhang Y, He S, Simpson B. A cold active transglutaminase from Antarctic krill (Euphausia superba): Purification, characterization and application in the modification of cold-set gelatin gel. Food Chem. 2017;232:155-162 pubmed publisher
    Transglutaminase (TGase), EC 2.3.2.13, was purified from whole Antarctic krill (Euphausia superba) using ammonium sulfate fractionation and DEAE-Sephacel chromatography...
  45. Guan C, Cui W, He X, Hu X, Xu J, Du G, et al. Construction and development of a novel expression system of Streptomyces. Protein Expr Purif. 2015;113:17-22 pubmed publisher
    ..expression in Streptomyces by inserting the promoter (P(tg)) and the signal peptide (SP(tg)) of transglutaminase (TGase) from Streptomyces hygroscopicus WSH03-13 into vector pIJ86, followed by multiple cloning sites and a ..
  46. Park M, Choi J, Kim H, Nakahata N, Lim K, Kim S, et al. Novel inhibitory effects of cardamonin on thromboxane A2-induced scratching response: Blocking of Gh/transglutaminase-2 binding to thromboxane A2 receptor. Pharmacol Biochem Behav. 2014;126:131-5 pubmed publisher
    ..Further, binding of high molecular G protein Gh/transglutaminase-2 (Gh/Tgase-2) to TXA2 receptor was confirmed in the A549 and SH-SY5Y cells by co-immunoprecipitation...
  47. Chen A, Tanidjaja I, Damodaran S. Nanostructure and functionality of enzymatically repolymerized whey protein hydrolysate. Food Chem. 2018;256:405-412 pubmed publisher
    Whey proteins (WPI) were polymerized with transglutaminase (TGase) before and after partially hydrolyzing the protein with thermolysin to produce protein nanoparticles/polymers...
  48. Tsybovskii I, Veremeichik V, Kotova S, Kritskaya S, Evmenenko S, Udina I. [Developing forensic reference database by 18 autosomal STR for DNA identification in Republic of Belarus]. Genetika. 2017;53:249-58 pubmed
    ..STR (D2S1338, TPOX, D3S1358, CSF1PO, D5S818, D8S1179, D7S820, THO1, vWA, D13S317, D16S539, D18S51, D19S433, D21S11, F13B, and FGA) and two pentanucleotide STR (Penta D and Penta E)...
  49. Junkunlo K, Soderhall K, Söderhäll I, Noonin C. Reactive Oxygen Species Affect Transglutaminase Activity and Regulate Hematopoiesis in a Crustacean. J Biol Chem. 2016;291:17593-601 pubmed publisher
    ..Extracellular transglutaminase (TGase) has been shown previously to play a role in maintaining HPT cells in an undifferentiated form...
  50. Zheng Z, Xu W, Aweya J, Zhong M, Liu S, Lun J, et al. Functional domains of Litopenaeus vannamei transglutaminase and their involvement in immunoregulation in shrimp. Fish Shellfish Immunol. 2018;81:168-175 pubmed publisher
    ..While transglutaminases (TGase) are found in Litopenaeus vannamei and constitute part of the coagulation system, the specific immune-related ..
  51. Cubedo J, Padro T, Pena E, Aledo R, Formiga F, Ferrer A, et al. High Levels of Antifibrinolytic Proteins Are Found in Plasma of Older Octogenarians With Cardiovascular Disease and Cognitive Decline. J Am Coll Cardiol. 2015;65:2667-2669 pubmed publisher
  52. Campos N, Torné J, Bleda M, Manich A, Urreta I, Montalbán I, et al. Proteomic and transcriptomic analysis of rice tranglutaminase and chloroplast-related proteins. Plant Sci. 2014;229:142-153 pubmed publisher
    ..Plant Sci. 205-206 (2013) 97-110). Similarly to its counterpart in maize (tgz), this rice TGase was localized in the chloroplast, although in this case not exclusively...
  53. Wolska J, Jonkers J, Holst O, Adlercreutz P. The addition of transglutaminase improves the physical quality of extruded fish feed. Biotechnol Lett. 2015;37:2265-70 pubmed publisher
    The possibility of improving the physical quality of extruded fish feed using transglutaminase (TGase) treatment at different stages of the production process was investigated...
  54. Zhu Y, Li D, Zhang X, Li X, Li W, Wang Q. Role of transglutaminase in immune defense against bacterial pathogens via regulation of antimicrobial peptides. Dev Comp Immunol. 2016;55:39-50 pubmed publisher
    Transglutaminase (TGase) is critical for blood coagulation, a conserved immunological defense mechanism among invertebrates...
  55. Cai G, Della Mea M, Faleri C, Fattorini L, Aloisi I, Serafini Fracassini D, et al. Spermine either delays or promotes cell death in Nicotiana tabacum L. corolla depending on the floral developmental stage and affects the distribution of transglutaminase. Plant Sci. 2015;241:11-22 pubmed publisher
    ..Moreover, SM deeply alters the distribution of the PA-conjugating enzyme transglutaminase (TGase)...
  56. Choi Y, Jeong T, Hwang K, Song D, Ham Y, Kim H, et al. Combined effects of Laminaria japonica and transglutaminase on physicochemical and sensory characteristics of semi-dried chicken sausages. Poult Sci. 2016;95:1943-9 pubmed publisher
    The effects of Laminaria japonica, Transglutaminase (TGase) and their combinations were investigated based on the physicochemical properties, textural properties, and sensory characteristics of semi-dried chicken sausages...
  57. An Y, You J, Xiong S, Yin T. Short-term frozen storage enhances cross-linking that was induced by transglutaminase in surimi gels from silver carp (Hypophthalmichthys molitrix). Food Chem. 2018;257:216-222 pubmed publisher
    To enhance the application of transglutaminase (TGase) in processing and preserving of frozen surimi, the mechanism that enhances surimi gelation induced by TGase after short-term freezing was investigated...
  58. Sirikharin R, Söderhäll I, Soderhall K. Characterization of a cold-active transglutaminase from a crayfish, Pacifastacus leniusculus. Fish Shellfish Immunol. 2018;80:546-549 pubmed publisher
    Transglutaminase (TGase) from signal crayfish (Pacifastacus leniusculus) and its activity at low temperatures was studied...
  59. Orosz Z, Katona E, Facsko A, Berta A, Muszbek L. A highly sensitive chemiluminescence immunoassay for the measurement of coagulation factor XIII subunits and their complex in tears. J Immunol Methods. 2010;353:87-92 pubmed publisher
    ..The developed methods provide a tool for monitoring FXIII subunit and complex levels in pathological conditions. ..
  60. Dong L, Wan J, Cao X. Separation of transglutaminase using aqueous two-phase systems composed of two pH-response polymers. J Chromatogr A. 2018;1555:106-112 pubmed publisher
    ..The main parameters, such as crude TGase feedstock load, the pH of system (pH 6.50-7...
  61. Kim N, Lee W, Lee S, Jin K, Kim K, Lee Y, et al. Inter-molecular crosslinking activity is engendered by the dimeric form of transglutaminase 2. Amino Acids. 2017;49:461-471 pubmed publisher
    Transglutaminase 2 (TGase 2) catalyzes a crosslink between protein bound-glutamine and -lysine. We proposed the mechanism of TGase 2 activation depends on conformation change from unfolded monomer to unfolded dimer...
  62. Keenan T, Toso M, Pappas C, Nichols L, Bishop P, Hageman G. Assessment of Proteins Associated With Complement Activation and Inflammation in Maculae of Human Donors Homozygous Risk at Chromosome 1 CFH-to-F13B. Invest Ophthalmol Vis Sci. 2015;56:4870-9 pubmed publisher
    ..Donor macular tissue was stratified into three groups by diplotype at the AMD-associated CFH-to-F13B locus: homozygous "risk" (n = 9, 56-78 years), homozygous neutral (n = 2, 64-79 years), and homozygous "protective" ..
  63. Yu J, Pian Y, Ge J, Guo J, Zheng Y, Jiang H, et al. Functional and Structural Characterization of the Antiphagocytic Properties of a Novel Transglutaminase from Streptococcus suis. J Biol Chem. 2015;290:19081-92 pubmed publisher
    ..a novel secreted immunogenic protein, SsTGase, containing a highly conserved eukaryotic-like transglutaminase (TGase) domain at the N terminus...
  64. Laranja J, Amar E, Ludevese Pascual G, Niu Y, Geaga M, De Schryver P, et al. A probiotic Bacillus strain containing amorphous poly-beta-hydroxybutyrate (PHB) stimulates the innate immune response of Penaeus monodon postlarvae. Fish Shellfish Immunol. 2017;68:202-210 pubmed publisher
    ..Relative expression of the immune related genes encoding for prophenoloxidase (proPO), transglutaminase (TGase) and heat shock protein 70 (Hsp70) in the shrimp were measured before (0 h) and after (3, 6, 9, 12, 24 h) the ..
  65. Kojima T, Mizoguchi T, Ota E, Hata J, Homma K, Zhu B, et al. Immobilization of proteins onto microbeads using a DNA binding tag for enzymatic assays. J Biosci Bioeng. 2016;121:147-53 pubmed publisher
    ..The scCro-tag successfully bound a transglutaminase 2 (TGase 2) substrate and manganese peroxidase (MnP) to microbeads via scaffolding DNA...
  66. González Giraldo Y, Rodríguez Dueñas M, Forero D. Development of Novel High-Resolution Melting-Based Assays for Genotyping Two Alu Insertion Polymorphisms (FXIIIB and PV92). Mol Biotechnol. 2016;58:197-201 pubmed publisher
    ..to develop high-resolution melting-based assays for genotyping two commonly studied Alu insertion polymorphisms: FXIIIB and PV92 (rs70942849 and rs3138523)...
  67. Wodtke R, Schramm G, Pietzsch J, Pietsch M, Löser R. Synthesis and Kinetic Characterisation of Water-Soluble Fluorogenic Acyl Donors for Transglutaminase?2. Chembiochem. 2016;17:1263-81 pubmed publisher
    ..were synthesised and investigated with regard to their potential to act as substrates for transglutaminase?2 (TGase?2). Their synthesis was accomplished by an efficient solid-phase approach...
  68. Luo R, Liu C, Elliott S, Wang W, Parchim N, Iriyama T, et al. Transglutaminase is a Critical Link Between Inflammation and Hypertension. J Am Heart Assoc. 2016;5: pubmed publisher
    ..Research reported here was undertaken to examine the role of transglutaminase (TGase) in LIGHT-induced hypertension...
  69. Delong T, Baker R, He J, Barbour G, Bradley B, Haskins K. Diabetogenic T-cell clones recognize an altered peptide of chromogranin A. Diabetes. 2012;61:3239-46 pubmed publisher
    ..WE14 can be converted into a highly antigenic T-cell epitope through treatment with the enzyme transglutaminase (TGase)...
  70. Domagała J, Najgebauer Lejko D, Wieteska Śliwa I, Sady M, Wszołek M, Bonczar G, et al. Influence of milk protein cross-linking by transglutaminase on the rennet coagulation time and the gel properties. J Sci Food Agric. 2016;96:3500-7 pubmed publisher
    Transglutaminase (TGase) modifies milk proteins by cross-linking of caseins, with increased cheese yield being the main technological benefit...
  71. D Eletto M, Farrace M, Piacentini M, Rossin F. Assessing the Catalytic Activity of Transglutaminases in the Context of Autophagic Responses. Methods Enzymol. 2017;587:511-520 pubmed publisher
    ..The vast array of biochemical functions catalyzed by TG2 distinguishes it from the other members of the TGase family...
  72. Sirikharin R, Junkunlo K, Söderhäll K, Söderhäll I. Role of astakine1 in regulating transglutaminase activity. Dev Comp Immunol. 2017;76:77-82 pubmed publisher
    Transglutaminase (TGase) has been implicated in maintaining the undifferentiated stage of hematopoietic stem cells (HSC) in the crayfish Pacifastacus leniusculus...
  73. Lee Y, Jung S, Hwang J, Jeon S, Han E, Park W, et al. Cysteamine prevents vascular leakage through inhibiting transglutaminase in diabetic retina. J Endocrinol. 2017;235:39-48 pubmed publisher
    ..We then investigated the potential roles of reactive oxygen species (ROS) and transglutaminase (TGase) in the cysteamine prevention of VEGF-induced vascular leakage...
  74. Kaetsu H, Hashiguchi T, Foster D, Ichinose A. Expression and release of the a and b subunits for human coagulation factor XIII in baby hamster kidney (BHK) cells. J Biochem. 1996;119:961-9 pubmed
    ..These results suggest that the a subunit is released from cells as a consequence of cell injury, which is independent of the classical secretory pathway. ..
  75. Liu Z, Zeng J, Zeng S, Tang B, Wang J. [Transglutaminase and neurodegenerative diseases]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2015;32:562-6 pubmed publisher
    Transglutaminase (TG) is a kind of calcium-dependent enzymes. The TGase family found in rodents and human contains 9 types, including TG1-7, blood coagulation factor XIIIa and erythrocyte membrane protein 4...
  76. Halicka H, Garcia J, Li J, Zhao H, Darzynkiewicz Z. Synergy of 2-deoxy-D-glucose combined with berberine in inducing the lysosome/autophagy and transglutaminase activation-facilitated apoptosis. Apoptosis. 2017;22:229-238 pubmed publisher
    ..was assessed by measuring DNA fragmentation, cell cycle, activation of caspase-3 and tissue transglutaminase (Tgase)...
  77. Wu X, Liu Y, Liu A, Wang W. Improved thermal-stability and mechanical properties of type I collagen by crosslinking with casein, keratin and soy protein isolate using transglutaminase. Int J Biol Macromol. 2017;98:292-301 pubmed publisher
    ..with higher molecule weight and relative bigger size particle occurred in the protein mixture, especially after TGase crosslinking...
  78. Kang J, Lee J, Hong D, Lee S, Kim N, Lee W, et al. Renal cell carcinoma escapes death by p53 depletion through transglutaminase 2-chaperoned autophagy. Cell Death Dis. 2016;7:e2163 pubmed publisher
    In renal cell carcinoma, transglutaminase 2 (TGase 2) crosslinks p53 in autophagosomes, resulting in p53 depletion and the tumor's evasion of apoptosis. Inhibition of TGase 2 stabilizes p53 and induces tumor cells to enter apoptosis...
  79. Achyuthan K, Rowland T, Birckbichler P, Lee K, Bishop P, Achyuthan A. Hierarchies in the binding of human factor XIII, factor XIIIa, and endothelial cell transglutaminase to human plasma fibrinogen, fibrin, and fibronectin. Mol Cell Biochem. 1996;162:43-9 pubmed
    ..Such hierarchies could regulate the cross-linkings by FXIIIa and Tg during hemostasis, wound healing, and cell adhesion. ..
  80. Zhang S, Li C, Gao X, Qiu W, Chen Q, Li X, et al. Identification and functional characterization of a novel transglutaminase 1 gene mutation associated with autosomal recessive congenital ichthyosis. Int J Dermatol. 2016;55:201-7 pubmed publisher
    ..Mutations in transglutaminase (TGase) 1 gene (TGM1, OMIM 190195) have been implicated in ARCI...
  81. Banach J, Clark S, Metzger L, Lamsal B. Textural performance of crosslinked or reduced-calcium milk protein ingredients in model high-protein nutrition bars. J Dairy Sci. 2016;99:6061-6070 pubmed publisher
    Transglutaminase (Tgase) crosslinking and calcium reduction were investigated as ways to improve the texture and storage stability of high-protein nutrition (HPN) bars formulated with milk protein concentrate (MPC) and micellar casein ..
  82. Mi Z, Si T, Kapadia K, Li Q, Muma N. Receptor-stimulated transamidation induces activation of Rac1 and Cdc42 and the regulation of dendritic spines. Neuropharmacology. 2017;117:93-105 pubmed publisher
    ..dendritic spine morphology and that activation of multiple types of receptors can induce transglutaminase (TGase)-catalyzed transamidation of small G proteins...
  83. Horimizu R, Ogawa R, Watanabe Y, Tatsukawa H, Kinoshita M, Hashimoto H, et al. Biochemical characterization of a medaka (Oryzias latipes) orthologue for mammalian Factor XIII and establishment of a gene-edited mutant. FEBS J. 2017;284:2843-2855 pubmed publisher
    ..molecules are stabilized via a catalytic reaction by Factor XIIIA (FXIIIA), a member of the transglutaminase (TGase) family that catalyzes protein cross-linking reactions...
  84. Cantsilieris S, White S, Richardson A, Guymer R, Baird P. Comprehensive analysis of Copy Number Variation of genes at chromosome 1 and 10 loci associated with late age related macular degeneration. PLoS ONE. 2012;7:e35255 pubmed publisher
    ..the Complement Factor H (CFH) gene, the 5 CFH-related (CFHR) genes representing a known copy number "hotspot", the F13B gene as well as the ARMS2 and HTRA1 genes in 387 cases of late AMD and 327 controls...
  85. Nawong S, Oonsivilai R, Boonkerd N, Truelstrup Hansen L. Entrapment in food-grade transglutaminase cross-linked gelatin-maltodextrin microspheres protects Lactobacillus spp. during exposure to simulated gastro-intestinal juices. Food Res Int. 2016;85:191-199 pubmed publisher
    ..gelatin-maltodextrin (G-MD) microspheres, where the gelatin was cross-linked with transglutaminase (TGase), to determine if encapsulated probiotic lactic acid bacteria were protected during exposure to simulated upper ..
  86. Yu J, Cheng H, Wu H, Wu W, Lu J, Cheng T, et al. Structure-based design of bacterial transglycosylase inhibitors incorporating biphenyl, amine linker and 2-alkoxy-3-phosphorylpropanoate moieties. Eur J Med Chem. 2018;150:729-741 pubmed publisher
    Transglycosylase (TGase) is essential to biosynthesis of peptidoglycan for formation of bacterial cell wall. Moenomycin is a potent TGase inhibitor, but not used in clinic treatment due to its poor pharmacokinetics...
  87. Hauser C, Wodtke R, Löser R, Pietsch M. A fluorescence anisotropy-based assay for determining the activity of tissue transglutaminase. Amino Acids. 2017;49:567-583 pubmed publisher
    Tissue transglutaminase (TGase 2) is the most abundantly expressed enzyme of the transglutaminase family and involved in a large variety of pathological processes, such as neurodegenerative diseases, disorders related to autoimmunity and ..
  88. Liu S, Wang M, Du G, Chen J. Improving the active expression of transglutaminase in Streptomyces lividans by promoter engineering and codon optimization. BMC Biotechnol. 2016;16:75 pubmed
    Transglutaminases (TGase), which are synthesized as a zymogen (pro-TGase) in Streptomyces sp., are important enzymes in the food industry...
  89. Katona E, Nagy B, Kappelmayer J, Baktai G, Kovacs L, Márialigeti T, et al. Factor XIII in bronchoalveolar lavage fluid from children with chronic bronchoalveolar inflammation. J Thromb Haemost. 2005;3:1407-13 pubmed
    ..By cross-linking fibrin and inhibitors of fibrinolysis to fibrin, FXIII might be a key regulator of fibrin turnover in the extravascular compartment. ..
  90. Koseki S, Souri M, Koga S, Yamakawa M, Shichishima T, Maruyama Y, et al. Truncated mutant B subunit for factor XIII causes its deficiency due to impaired intracellular transportation. Blood. 2001;97:2667-72 pubmed
    ..These results support a previous conclusion that genetic defects of XIIIB are the basis for the former type I factor XIII deficiency. ..
  91. Pruissen D, Slooter A, Rosendaal F, van der Graaf Y, Algra A. Coagulation factor XIII gene variation, oral contraceptives, and risk of ischemic stroke. Blood. 2008;111:1282-6 pubmed
    ..A total of 4 variants of coagulation factor XIII subunit A and B genes (F13A1 and F13B) were investigated...
  92. Biswas A, Ivaskevicius V, Seitz R, Thomas A, Oldenburg J. An update of the mutation profile of Factor 13 A and B genes. Blood Rev. 2011;25:193-204 pubmed publisher
    ..The F13B gene remains an elusive component as far as inherited Factor XIII deficiencies are concerned...