Gene Symbol: F11
Description: coagulation factor XI
Alias: FXI, PTA, coagulation factor XI, plasma thromboplastin antecedent
Species: human
Products:     F11

Top Publications

  1. Smith N, Hindorff L, Heckbert S, Lemaitre R, Marciante K, Rice K, et al. Association of genetic variations with nonfatal venous thrombosis in postmenopausal women. JAMA. 2007;297:489-98 pubmed
    ..Replication of these novel associations in other populations is necessary to corroborate these findings and identify which genetic factors may influence VT risk in postmenopausal women. ..
  2. Salomon O, Steinberg D, Koren Morag N, Tanne D, Seligsohn U. Reduced incidence of ischemic stroke in patients with severe factor XI deficiency. Blood. 2008;111:4113-7 pubmed publisher
    ..Thus, severe factor XI deficiency probably is protective against ischemic stroke but not against acute myocardial infarction. ..
  3. Kravtsov D, Matafonov A, Tucker E, Sun M, Walsh P, Gruber A, et al. Factor XI contributes to thrombin generation in the absence of factor XII. Blood. 2009;114:452-8 pubmed publisher
    During surface-initiated blood coagulation in vitro, activated factor XII (fXIIa) converts factor XI (fXI) to fXIa...
  4. Li Y, Bezemer I, Rowland C, Tong C, Arellano A, Catanese J, et al. Genetic variants associated with deep vein thrombosis: the F11 locus. J Thromb Haemost. 2009;7:1802-8 pubmed publisher
    ..2 locus that contains genes encoding factor XI (F11), a cytochrome P450 family member (CYP4V2), and prekallikrein (KLKB1)...
  5. Cushman M, O Meara E, Folsom A, Heckbert S. Coagulation factors IX through XIII and the risk of future venous thrombosis: the Longitudinal Investigation of Thromboembolism Etiology. Blood. 2009;114:2878-83 pubmed publisher
    ..3-2.7). Associations were similar by study and whether the thrombosis was idiopathic or secondary. Factor XII deficiency was not related to VTE risk. Among these procoagulant factors, only elevated factor XI was a risk factor for VTE. ..
  6. Delluc A, Gourhant L, Lacut K, Mercier B, Audrezet M, Nowak E, et al. Association of common genetic variations and idiopathic venous thromboembolism. Results from EDITh, a hospital-based case-control study. Thromb Haemost. 2010;103:1161-9 pubmed publisher
    ..In this hospital-based case-control study, two polymorphisms located on the factor XI gene were significantly associated with VTE. Other newly investigated polymorphisms with potentially false negatives may warrant further analyses. ..
  7. Salomon O, Steinberg D, Zucker M, Varon D, Zivelin A, Seligsohn U. Patients with severe factor XI deficiency have a reduced incidence of deep-vein thrombosis. Thromb Haemost. 2011;105:269-73 pubmed publisher
    Factor XI (FXI) plays a dual role in haemostasis and thrombosis. It contributes to thrombin generation and promotes inhibition of fibrinolysis...
  8. Seligsohn U. Factor XI in haemostasis and thrombosis: past, present and future. Thromb Haemost. 2007;98:84-9 pubmed
  9. Undas A, Slowik A, Gissel M, Mann K, Butenas S. Circulating activated factor XI and active tissue factor as predictors of worse prognosis in patients following ischemic cerebrovascular events. Thromb Res. 2011;128:e62-6 pubmed publisher
    Elevated factor (F)XI is associated with an increased risk for ischemic stroke. Activated FXI (FXIa) and tissue factor (TF) have not been studied following stroke...

More Information

Publications135 found, 100 shown here

  1. Fitzsimons M, Leaf R, Mack J, Bendapudi P, Shen T, Cameron D. Perioperative management of a redo aortic root replacement in a patient with severe factor XI deficiency. J Card Surg. 2018;33:86-89 pubmed publisher
    ..We present a patient with FXI deficiency and multiple red blood cell allo-antibodies requiring repeat aortic root replacement and discuss the ..
  2. Sheffield W, Eltringham Smith L, Bhakta V. A factor XIa-activatable hirudin-albumin fusion protein reduces thrombosis in mice without promoting blood loss. BMC Biotechnol. 2018;18:21 pubmed publisher
    ..Because coagulation factor XI (FXI) is more involved in thrombosis than hemostasis, we hypothesized that making HV3 activity FXIa-..
  3. Duncan E, Rodgers S. One-Stage Factor VIII Assays. Methods Mol Biol. 2017;1646:247-263 pubmed publisher
    ..FVIII:C-1), with extra information provided to also allow this method to apply to Factor IX (FIX), Factor XI (FXI), and Factor XII (FXII)...
  4. Franco Murillo Y, Jaimez R. Inhibitory effect of ethinylestradiol on coagulation factors in rats. Exp Anim. 2017;66:107-113 pubmed publisher
    ..PT) and activated partial thromboplastin time (APTT), as well as the activity of coagulation factors (FVII, FX, FXI, and FXII) in male Wistar rats...
  5. Lindahl T, Ramström S, Boknäs N, Faxälv L. Caveats in studies of the physiological role of polyphosphates in coagulation. Biochem Soc Trans. 2016;44:35-9 pubmed publisher
    ..dense granule and released upon platelet activation, have been claimed to enhance thrombin activation of coagulation factor XI (FXI) and to activate FXII directly...
  6. Pike G, Cumming A, Thachil J, Hay C, Bolton Maggs P, Burthem J. Evaluation of the use of rotational thromboelastometry in the assessment of FXI deficency. Haemophilia. 2017;23:449-457 pubmed publisher
    The absence of a reliable clinical test to predict bleeding tendency leaves factor XI (FXI)-deficient individuals at risk of overtreatment or under treatment.
  7. Park D, Kang G, Kang D, Hong J, Lee M, Kim K, et al. A new manufacturing process to remove thrombogenic factors (II, VII, IX, X, and XI) from intravenous immunoglobulin gamma preparations. Biologicals. 2017;45:1-8 pubmed publisher
    ..16 mIU/mL, non-activated partial thromboplastin time (NaPTT): >250 s, FXI/FXIa ELISA: <0.31 ng/mL. Even after spiking with FXIa at a concentration 32...
  8. Vu T, Leslie B, Stafford A, Zhou J, Fredenburgh J, Weitz J. Histidine-rich glycoprotein binds DNA and RNA and attenuates their capacity to activate the intrinsic coagulation pathway. Thromb Haemost. 2016;115:89-98 pubmed publisher
    ..in the presence of prekallikrein- and high molecular weight kininogen (HK), and b) enhance thrombin-mediated FXI activation by 10- to 12-fold...
  9. Li S, Shen C, Shu K, Liu J, Wang X, Li F, et al. [Phenotypic and genetic analysis of two pedigrees affected with hereditary coagulation FXII deficiency]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2018;35:800-803 pubmed publisher
    ..fibrinogen (FIB), thrombin time (TT), and blood coagulation factor VIII, IX, XI, XII activity (FVIII:C, FIX:C, FXI:C, FXII:C) were determined with one stage clotting assay on a STAGO coagulation analyzer...
  10. Ivanov I, Matafonov A, Sun M, Cheng Q, Dickeson S, Verhamme I, et al. Proteolytic properties of single-chain factor XII: a mechanism for triggering contact activation. Blood. 2017;129:1527-1537 pubmed publisher
    ..an inducer of contact activation, enhances PK activation by FXII-T, and facilitates FXII-T activation of FXII and FXI. In plasma, FXII-T and FXII-R353A, but not FXII lacking the active site serine residue (FXII-S544A), shortened the ..
  11. Lallukka S, Luukkonen P, Zhou Y, Isokuortti E, Leivonen M, Juuti A, et al. Obesity/insulin resistance rather than liver fat increases coagulation factor activities and expression in humans. Thromb Haemost. 2017;117:286-294 pubmed publisher
    ..of pro-inflammatory genes in adipose tissue correlated positively with PT (% of normal), circulating FVIII, FIX, FXI, VWR:RCo and fibrinogen, and expression of anti-inflammatory genes negatively with PT (%), FIX and fibrinogen...
  12. Delabranche X, Helms J, Meziani F. Immunohaemostasis: a new view on haemostasis during sepsis. Ann Intensive Care. 2017;7:117 pubmed publisher
    ..thrombin and fibrin generation could benefit from available (antithrombin, soluble thrombomodulin) or ongoing (FXI and FXII inhibitors) therapies...
  13. Marmouzi I, Karym E, Saidi N, Meddah B, Kharbach M, Masrar A, et al. In Vitro and In Vivo Antioxidant and Anti-Hyperglycemic Activities of Moroccan Oat Cultivars. Antioxidants (Basel). 2017;6: pubmed publisher
    ..This work aims to evaluate the protective effect of phenolic compounds from hybrid Oat line (F11-5) and its parent (Amlal) on hyperglycemia-induced oxidative stress and to establish the possible mechanisms of ..
  14. Santos B, Oliveira M, Coelho P, Pitanga B, da Silva A, Adelita T, et al. Flavonoids suppress human glioblastoma cell growth by inhibiting cell metabolism, migration, and by regulating extracellular matrix proteins and metalloproteinases expression. Chem Biol Interact. 2015;242:123-38 pubmed publisher
    ..the effects of several polyhydroxylated flavonoids namely, rutin, quercetin (F7), apigenin (F32), chrysin (F11), kaempferol (F12), and 3',4'-dihydroxyflavone (F2) in human GL-15 glioblastoma cells...
  15. Smyth D, Harcus Y, White M, Gregory W, Nahler J, Stephens I, et al. TGF-β mimic proteins form an extended gene family in the murine parasite Heligmosomoides polygyrus. Int J Parasitol. 2018;48:379-385 pubmed publisher
    ..five of the nine new TGM members were tested for TGF-β activity, but only two were functionally active in an MFB-F11 reporter assay, and by the induction of T cell Foxp3 expression...
  16. Maier F, Wild A, Kirchen N, Holm F, Fuchs K, Schwenck J, et al. Comparative immuno-Cerenkov luminescence and -PET imaging enables detection of PSMA+ tumors in mice using 64Cu-radiolabeled monoclonal antibodies. Appl Radiat Isot. 2019;143:149-155 pubmed publisher
    ..days immuno-CLI and -PET of the applied 64Cu-labeled and well described monoclonal antibody 3/F11 in prostate-specific membrane antigen (PSMA)-positive (C4-2, PSMA+) and -negative (DU 145, PSMA-
  17. Csuka D, Veszeli N, Imreh Ã, Zotter Z, Skopál J, Prohászka Z, et al. Comprehensive study into the activation of the plasma enzyme systems during attacks of hereditary angioedema due to C1-inhibitor deficiency. Orphanet J Rare Dis. 2015;10:132 pubmed publisher
    ..Compared with the healthy controls, significantly higher FXI and FXII activity (p = 0.0007, p = 0.005), as well as D-dimer (p < 0...
  18. Wolf P, Alt K, Wetterauer D, Bühler P, Gierschner D, Katzenwadel A, et al. Preclinical evaluation of a recombinant anti-prostate specific membrane antigen single-chain immunotoxin against prostate cancer. J Immunother. 2010;33:262-71 pubmed publisher
    ..an anti-PSMA single-chain antibody fragment (scFv), called D7, by phage display from the monoclonal antibody 3/F11. By C-terminal ligation of the toxic domain of Pseudomonas Exotoxin A (PE40) to the genes of D7, the immunotoxin D7-..
  19. Russell C, Richards A, Chang A, Mulvey M. The Rhomboid Protease GlpG Promotes the Persistence of Extraintestinal Pathogenic Escherichia coli within the Gut. Infect Immun. 2017;85: pubmed publisher
    ..A screen using transposon sequencing (Tn-seq) was performed to search for genes within ExPEC isolate F11 that are important for growth in intestinal mucus, which is thought to be a major source of nutrients for E...
  20. Buckles E, Luterbach C, Wang X, Lockatell C, Johnson D, Mobley H, et al. Signature-tagged mutagenesis and co-infection studies demonstrate the importance of P fimbriae in a murine model of urinary tract infection. Pathog Dis. 2015;73: pubmed publisher
    ..coli F11. A P-fimbrial mutant was outcompeted by the wild-type strain in cochallenge in the murine model of ascending UTI, ..
  21. Germain M, Chasman D, de Haan H, Tang W, Lindström S, Weng L, et al. Meta-analysis of 65,734 individuals identifies TSPAN15 and SLC44A2 as two susceptibility loci for venous thromboembolism. Am J Hum Genet. 2015;96:532-42 pubmed publisher
    ..genome-wide significance level of 5 × 10(-8) including six already known to associate with VTE (ABO, F2, F5, F11, FGG, and PROCR) and three unsuspected loci...
  22. Torán J, Lopez J, Gomes Alves P, Aguilar S, Torroja C, Trevisan Herraz M, et al. Definition of a cell surface signature for human cardiac progenitor cells after comprehensive comparative transcriptomic and proteomic characterization. Sci Rep. 2019;9:4647 pubmed publisher
    ..GPR4 (G protein-coupled receptor 4), CACNG7 (calcium voltage-gated channel auxiliary subunit gamma 7) and F11R (F11 receptor; junctional adhesion molecule A; JAM-A; CD321) were selected for validation...
  23. Verma S, Joseph S, Verma R, Kushwaha V, Parmar N, Yadav P, et al. Protection against filarial infection by 45-49 kDa molecules of Brugia malayi via IFN-γ-mediated iNOS induction. Vaccine. 2015;33:527-34 pubmed publisher
    ..Three predominantly NO-stimulating SDS-PAGE resolved fractions F8 (45.24-48.64 kDa), F11 (33.44-38.44 kDa) and F12 (28.44-33.44 kDa) from B...
  24. Rousseau A, Larsen A, Van Dreden P, Sabbah M, Elalamy I, Gerotziafas G. Differential contribution of tissue factor and Factor XII to thrombin generation triggered by breast and pancreatic cancer cells. Int J Oncol. 2017;51:1747-1756 pubmed publisher
    ..TG enhancement by both BXPC3 and MCF7 cells was mediated by FVII and intrinsic tenase while FXII and FXI were also important for MCF7 cells...
  25. Mokrousov I, Vyazovaya A, Iwamoto T, Skiba Y, Pole I, Zhdanova S, et al. Latin-American-Mediterranean lineage of Mycobacterium tuberculosis: Human traces across pathogen's phylogeography. Mol Phylogenet Evol. 2016;99:133-143 pubmed publisher
    ..SIT33-sublineage is marked with enigmatic gaps and peaks across the Americas and includes South African clade F11/RD761, which likely emerged within the SIT33 subpopulation after its arrival to Africa...
  26. Im Y, Lee Y, Park J, Kim H, Im S, Song H, et al. GPCR Kinase (GRK)-2 Is a Key Negative Regulator of Itch: l-Glutamine Attenuates Itch via a Rapid Induction of GRK2 in an ERK-Dependent Way. J Invest Dermatol. 2018;138:1834-1842 pubmed publisher
    ..in not only dinitrochlorobenzene-induced CD (within 10 minutes) but also cultured rat dorsal root ganglion cells, F11 (within 1 minute)...
  27. Loh Z, Elkordy A. Formulation and evaluation of different floating tablets containing metronidazole to target stomach. Curr Drug Deliv. 2015;12:425-43 pubmed
    ..Most of the tablets show good physicochemical properties except for F11 which contains pluronic® F-127 as its release-retarding matrix-forming polymer...
  28. Terral G, Champion T, Debaene F, Colas O, Bourguet M, Wagner Rousset E, et al. Epitope characterization of anti-JAM-A antibodies using orthogonal mass spectrometry and surface plasmon resonance approaches. MAbs. 2017;9:1317-1326 pubmed publisher
    ..different binding stoichiometries and affinities, with two molecules of JAM-A being able to bind to hz6F4-2 and F11 Fab, while only one JAM-A was bound to J10.4...
  29. Mvubu N, Pillay B, Gamieldien J, Bishai W, Pillay M. Canonical pathways, networks and transcriptional factor regulation by clinical strains of Mycobacterium tuberculosis in pulmonary alveolar epithelial cells. Tuberculosis (Edinb). 2016;97:73-85 pubmed publisher
    ..biosynthesis and immune associated pathways revealed similar patterns for Beijing and Unique; F15/LAM4/KZN and F11; and, F28 and H37Rv strains, respectively. However, the induction of top scoring networks varied among the strains...
  30. Girolami A, Silvia F, Elisabetta C, Edoardo P, Bruno G. Ischemic Strokes in Congenital Bleeding Disorders: Comparison with Myocardial Infarction and other Acute Coronary Syndromes. Cardiovasc Hematol Disord Drug Targets. 2016;16:6-12 pubmed
    ..defects or Factor VII deficiency; seven patients had Hemophilia (6 hemophilia A and 1 hemophilia B); eight cases of FXI deficiency and six patients with von Willebrand Disease. One patient had a congenital platelet disorder...
  31. Miller T, Sinha D, Baird T, Walsh P. A catalytic domain exosite (Cys527-Cys542) in factor XIa mediates binding to a site on activated platelets. Biochemistry. 2007;46:14450-60 pubmed
  32. Suchoń P, Al Frouh F, Ibrahim M, Sarlon G, Venton G, Alessi M, et al. Genetic risk factors for venous thrombosis in women using combined oral contraceptives: update of the PILGRIM study. Clin Genet. 2017;91:131-136 pubmed publisher
    ..Nine polymorphisms located on KNG1, F11, F5, F2, PROCR, FGG, TSPAN and SLC44A2 genes were genotyped in a sample of 766 patients and 464 controls as part of ..
  33. Wojcik E, Van den Berg M, Poort S, Bertina R. Modification of the N-terminus of human factor IX by defective propeptide cleavage or acetylation results in a destabilized calcium-induced conformation: effects on phospholipid binding and activation by factor XIa. Biochem J. 1997;323 ( Pt 3):629-36 pubmed
    ..Our results indicate that mutations in FIX that interfere with propeptide cleavage affect the function of the protein mainly by destabilizing the calcium-induced conformation. ..
  34. Wistinghausen B, Reischer A, Oddoux C, Ostrer H, Nardi M, Karpatkin M. Severe factor XI deficiency in an Arab family associated with a novel mutation in exon 11. Br J Haematol. 1997;99:575-7 pubmed
    ..We postulate that this substitution interferes with folding and secretion of the molecule. ..
  35. Lee S, Dickson R, Lin C. Activation of hepatocyte growth factor and urokinase/plasminogen activator by matriptase, an epithelial membrane serine protease. J Biol Chem. 2000;275:36720-5 pubmed
  36. Bicocchi M, Rosano C, Acquila M. Genetic analysis in FXI deficient patients from northwestern Italy: three novel and one recurrent mutation. Eur J Haematol. 2013;90:351-3 pubmed publisher
  37. Gupta S, Kumar T, Verma S, Bharadwaj C, Bhatia S. Development of gene-based markers for use in construction of the chickpea (Cicer arietinum L.) genetic linkage map and identification of QTLs associated with seed weight and plant height. Mol Biol Rep. 2015;42:1571-80 pubmed publisher
    ..A F11 population of 177 recombinant inbred lines derived from a cross between SBD377 (100-seed weight--48 g and plant ..
  38. Zamolodchikov D, Renné T, Strickland S. The Alzheimer's disease peptide β-amyloid promotes thrombin generation through activation of coagulation factor XII. J Thromb Haemost. 2016;14:995-1007 pubmed publisher
    ..Factor (F) XII initiates blood clotting via FXI, and thrombosis has been implicated in AD...
  39. Tripodi A. Detection of procoagulant imbalance. Modified endogenous thrombin potential with results expressed as ratio of values with-to-without thrombomodulin. Thromb Haemost. 2017;117:830-836 pubmed publisher
    ..Furthermore, owing to the many feedback mechanisms mediated by thrombin (e.?g. activation of PC, FXI, FV, FVIII, platelets etc...
  40. Baird T, Walsh P. Activated platelets but not endothelial cells participate in the initiation of the consolidation phase of blood coagulation. J Biol Chem. 2002;277:28498-503 pubmed
    ..phase of coagulation occurs on platelets or on endothelium, we have examined the interaction of coagulation factor XI with human umbilical vein endothelial cells (HUVEC) and with platelets...
  41. Ishikawa N, Okada S, Sato T, Yasunaga S, Ohtsubo M, Takihara Y, et al. A novel mutation (Gln433Glu) in exon 12 combined with the G insertion in exon 13 causes severe factor XI deficiency in Japanese patients. Blood Coagul Fibrinolysis. 2007;18:519-23 pubmed
    ..We identified a novel mutation, a C-to-G transition at position 1394 in exon 12 in the FXI gene (F11 c.1394 C>G)...
  42. Whelihan M, Orfeo T, Gissel M, Mann K. Coagulation procofactor activation by factor XIa. J Thromb Haemost. 2010;8:1532-9 pubmed publisher
    ..In the APTT assay, FXII is activated on a negatively charged surface and proceeds to activate FXI, which activates FIX upon the addition of Ca(2+). FIXa feeds thrombin generation through activation of FX...
  43. Salloum Asfar S, Teruel Montoya R, Arroyo A, García Barberá N, Chaudhry A, Schuetz E, et al. Regulation of coagulation factor XI expression by microRNAs in the human liver. PLoS ONE. 2014;9:e111713 pubmed publisher
    High levels of factor XI (FXI) increase the risk of thromboembolic disease. However, the genetic and environmental factors regulating FXI expression are still largely unknown...
  44. Jang J, Lee S, Oh H, Choi Y, Choi J, Hwang D, et al. Fluorescence imaging of in vivo miR-124a-induced neurogenesis of neuronal progenitor cells using neuron-specific reporters. EJNMMI Res. 2016;6:38 pubmed publisher
    ..Neurite outgrowth was clearly seen in F11 cells after miR-124a transfection, and immunofluorescence staining showed increase of Tuj1 and NF at 48 hours...
  45. Santos I, Almeida A, Pirovani C, Costa M, Silva M, Bellete B, et al. Differential accumulation of flavonoids and phytohormones resulting from the canopy/rootstock interaction of citrus plants subjected to dehydration/rehydration. Plant Physiol Biochem. 2017;119:147-158 pubmed publisher
    ..Leaf levels of GFs (vicenin, F11, rutin and rhoifolin) were particularly modulated by drought in plants with 'Rangpur Santa Cruz' lime rootstock, ..
  46. Tiscia G, Favuzzi G, Lupone M, Cappucci F, Schiavulli M, Mirabelli V, et al. Factor XI gene variants in factor XI-deficient patients of Southern Italy: identification of a novel mutation and genotype-phenotype relationship. Hum Genome Var. 2017;4:17043 pubmed publisher
    Congenital Factor XI (FXI) deficiency shows a high variability in clinical phenotype. To date, many allele variants have been shown to cause this bleeding disorder. However, the genotype-phenotype relationship is difficult to establish...
  47. Salloum Asfar S, de la Morena Barrio M, Esteban J, Minano A, Aroca C, Vicente V, et al. Assessment of two contact activation reagents for the diagnosis of congenital factor XI deficiency. Thromb Res. 2018;163:64-70 pubmed publisher
    Congenital FXI deficiency, a coagulopathy associated with low bleeding risk but thrombotic protection, is usually diagnosed by prolonged APTT and confirmed by coagulation assays...
  48. Wuillemin W, Bleeker W, Agterberg J, Rigter G, ten Cate H, Hack C. Clearance of human factor XIa-inhibitor complexes in rats. Br J Haematol. 1996;93:950-4 pubmed
    ..Furthermore, measuring FXIa-FXIa inhibitor complexes in patient samples may not help to clarify the relative contribution of the individual serpins to inactivation of FXIa in vivo. ..
  49. Zivelin A, Bauduer F, Ducout L, Peretz H, Rosenberg N, Yatuv R, et al. Factor XI deficiency in French Basques is caused predominantly by an ancestral Cys38Arg mutation in the factor XI gene. Blood. 2002;99:2448-54 pubmed
    ..005. Haplotype analysis based on the study of 10 intragenic polymorphisms was consistent with a common ancestry (a founder effect) for the Cys38Arg mutation. ..
  50. Schmidt A, Ogawa T, Gailani D, Bajaj S. Structural role of Gly(193) in serine proteases: investigations of a G555E (GLY193 in chymotrypsin) mutant of blood coagulation factor XI. J Biol Chem. 2004;279:29485-92 pubmed
    ..A patient with inherited deficiency of the coagulation serine protease factor XI (FXI) was reported to be homozygous for a Gly(555) --> Glu substitution...
  51. Zucker M, Zivelin A, Landau M, Salomon O, Kenet G, Bauduer F, et al. Characterization of seven novel mutations causing factor XI deficiency. Haematologica. 2007;92:1375-80 pubmed
    Factor XI (FXI) deficiency is a rare autosomal recessive disorder, the main manifestation of which is injury-related bleeding...
  52. Giannakopoulos B, Gao L, Qi M, Wong J, Yu D, Vlachoyiannopoulos P, et al. Factor XI is a substrate for oxidoreductases: enhanced activation of reduced FXI and its role in antiphospholipid syndrome thrombosis. J Autoimmun. 2012;39:121-9 pubmed publisher
    Factor XI (FXI), a disulfide-linked covalent homodimer, circulates in plasma, and upon activation initiates the intrinsic/consolidation phase of coagulation...
  53. Hinds D, Buil A, Ziemek D, Martinez Perez A, Malik R, Folkersen L, et al. Genome-wide association analysis of self-reported events in 6135 individuals and 252 827 controls identifies 8 loci associated with thrombosis. Hum Mol Genet. 2016;25:1867-74 pubmed publisher
    ..significant results, our study replicated previously known venous thromboembolism (VTE) loci near the F5, FGA-FGG, F11, F2, PROCR and ABO genes, and the more recently discovered locus near SLC44A2 In addition, our study reports for ..
  54. Ivanov I, Shakhawat R, Sun M, Dickeson S, Puy C, McCarty O, et al. Nucleic acids as cofactors for factor XI and prekallikrein activation: Different roles for high-molecular-weight kininogen. Thromb Haemost. 2017;117:671-681 pubmed publisher
    The plasma zymogens factor XI (fXI) and prekallikrein (PK) are activated by factor XIIa (fXIIa) during contact activation...
  55. Zakai N, Olson N, Judd S, Kleindorfer D, Kissela B, Howard G, et al. Haemostasis biomarkers and risk of intracerebral haemorrhage in the REasons for Geographic and Racial Differences in Stroke Study. Thromb Haemost. 2017;117:1808-1815 pubmed publisher
    ..Haemostasis biomarkers (factor VIII (FVIII), factor IX (FIX), factor XI (FXI), fibrinogen, protein C, and D-dimer) were measured in a case cohort study consisting of ICH and a 1,104 person ..
  56. González Ramírez R, Martínez Hernández E, Sandoval A, Gómez Mora K, Felix R. Regulation of the voltage-gated Ca2+ channel CaVα2δ-1 subunit expression by the transcription factor Egr-1. Neurosci Lett. 2018;673:136-141 pubmed publisher
    ..ganglion (DRG) neurons, while overexpression of the transcription factor increased Ca2+ currents in the F11 cell line, a hybrid of DRG and N18TG2 neuroblastoma cells...
  57. Thompson R, Mandle R, Kaplan A. Studies of binding of prekallikrein and Factor XI to high molecular weight kininogen and its light chain. Proc Natl Acad Sci U S A. 1979;76:4862-6 pubmed
  58. Meijers J, Kanters D, Vlooswijk R, van Erp H, Hessing M, Bouma B. Inactivation of human plasma kallikrein and factor XIa by protein C inhibitor. Biochemistry. 1988;27:4231-7 pubmed
    ..APC and kallikrein formed 1:1 molar complexes with PCI.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  59. Salomon O, Steinberg D, Dardik R, Rosenberg N, Zivelin A, Tamarin I, et al. Inherited factor XI deficiency confers no protection against acute myocardial infarction. J Thromb Haemost. 2003;1:658-61 pubmed
    Factor XI (FXI) contributes to thrombin generation thereby affecting fibrin formation and to down regulation of fibrinolysis by activation of thrombin-activatable fibrinolysis inhibitor (TAFI)...
  60. Lavigne G, Mercier E, Quere I, Dauzat M, Gris J. Thrombophilic families with inheritably associated high levels of coagulation factors VIII, IX and XI. J Thromb Haemost. 2003;1:2134-9 pubmed
    ..The association of high levels of coagulation FXI, FIX and FVIII is thus a new rare high-risk inherited thrombophilia syndrome.
  61. Podmore A, Smith M, Savidge G, Alhaq A. Real-time quantitative PCR analysis of factor XI mRNA variants in human platelets. J Thromb Haemost. 2004;2:1713-9 pubmed
    b>Coagulation factor XI (FXI) plays an essential role in blood coagulation...
  62. White Adams T, Berny M, Tucker E, Gertz J, Gailani D, Urbanus R, et al. Identification of coagulation factor XI as a ligand for platelet apolipoprotein E receptor 2 (ApoER2). Arterioscler Thromb Vasc Biol. 2009;29:1602-7 pubmed publisher
    Factor XI (FXI) promotes hemostasis and thrombosis through enhancement of thrombin generation and has been shown to play a critical role in the formation of occlusive thrombi in arterial injury models...
  63. Turkmen M, Toprak C, Acar G, Tabakçi M, Durmuş H, Yazicioglu M, et al. Plasma factor XI and XII activity in patients with slow coronary flow. Blood Coagul Fibrinolysis. 2015;26:858-61 pubmed publisher
    ..119.1?±?16, P?=?0.001, respectively). We conclude that SCF phenomenon appears to be associated with enhanced procoagulant state, which may support the role of inflammation and atherosclerosis in the pathogenesis of this phenomenon. ..
  64. Gailani D, Geng Y, Verhamme I, Sun M, Bajaj S, Messer A, et al. The mechanism underlying activation of factor IX by factor XIa. Thromb Res. 2014;133 Suppl 1:S48-51 pubmed publisher
    Factor XI (fXI) is the zymogen of a plasma protease, factor XIa (fXIa), that contributes to thrombin generation during blood coagulation by proteolytic conversion of factor IX (fIX) to factor IXa? (fIXa?)...
  65. Sokol J, Biringer K, Skerenova M, Stasko J, Kubisz P. Activity of coagulation factor XI in patients with spontaneous miscarriage: the presence of risk alleles. J Obstet Gynaecol. 2015;35:621-4 pubmed publisher
    The aim of this study was to compare the activity of coagulation factor XI (FXI) between patients with spontaneous miscarriage versus control group with no history of miscarriage and thrombosis, and then we evaluated the occurrence of ..
  66. Garg J, Chaudhary R, Krishnamoorthy P, Palaniswamy C, Shah N, Bozorgnia B, et al. Safety and efficacy of oral factor-Xa inhibitors versus Vitamin K antagonist in patients with non-valvular atrial fibrillation: Meta-analysis of phase II and III randomized controlled trials. Int J Cardiol. 2016;218:235-239 pubmed publisher
    ..Phase II and III randomized controlled trials that reported clinical safety and efficacy of FXI in patients with NVAF were identified from MEDLINE, Embase, and Cochrane Central Register of Controlled Trials ..
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    ..Fasudil reduced LPS-mediated TF and PAI-1 expression and activity in PBMCs. These effects may partially be relevant to the clinical benefits of fasudil in the treatment of CAPD patients. ..
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    The tumor specificity of JAA-F11, a novel monoclonal antibody specific for the Thomsen-Friedenreich cancer antigen (TF-Ag-alpha linked), has been comprehensively studied by in vitro immunohistochemical (IHC) staining of human tumor and ..
  69. Buetow K, Shiang R, Yang P, Nakamura Y, Lathrop G, White R, et al. A detailed multipoint map of human chromosome 4 provides evidence for linkage heterogeneity and position-specific recombination rates. Am J Hum Genet. 1991;48:911-25 pubmed
    ..It additionally provides evidence for position-specific recombination frequencies in the telomeric region of 4p. ..
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    The Glu117stop mutation in the factor XI (FXI) gene is the most common cause of FXI deficiency and might cause the disease either by poor secretion/stability of the truncated protein or by decreased mRNA levels...
  73. Klarin D, Emdin C, Natarajan P, Conrad M, Kathiresan S. Genetic Analysis of Venous Thromboembolism in UK Biobank Identifies the ZFPM2 Locus and Implicates Obesity as a Causal Risk Factor. Circ Cardiovasc Genet. 2017;10: pubmed publisher
    ..The genome-wide association study for VTE replicated previous findings at the F5, F2, ABO, F11, and FGG loci...
  74. Mvubu N, Pillay B, McKinnon L, Pillay M. Mycobacterium tuberculosis strains induce strain-specific cytokine and chemokine response in pulmonary epithelial cells. Cytokine. 2018;104:53-64 pubmed publisher
    ..performed at 24, 48 and 72h post infection of the A549 pulmonary epithelial cell line with the F15/LAM4/KZN, F28, F11, Beijing, Unique and H37Rv strains at an MOI of ∼10:1...
  75. Badellino K, Walsh P. Localization of a heparin binding site in the catalytic domain of factor XIa. Biochemistry. 2001;40:7569-80 pubmed
    ..We conclude that residues (529)K, (530)R, and (532)R comprise a high-affinity heparin-binding site in the factor XIa catalytic domain. ..
  76. Quelin F, Trossaert M, Sigaud M, Mazancourt P, Fressinaud E. Molecular basis of severe factor XI deficiency in seven families from the west of France. Seven novel mutations, including an ancient Q88X mutation. J Thromb Haemost. 2004;2:71-6 pubmed
    ..particular, two mutations--a stop mutation (type II) and a missense mutation (type III)--which are responsible for FXI deficiency, predominate...
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    Severe factor XI (FXI) deficiency is an injury-related bleeding disorder, common in Ashkenazi Jews (with two mutations prevailing), but rare worldwide (with heterogeneous mutations)...
  79. Schielmann M, Szweda P, Gucwa K, Kawczyński M, Milewska M, Martynow D, et al. Transport Deficiency Is the Molecular Basis of Candida albicans Resistance to Antifungal Oligopeptides. Front Microbiol. 2017;8:2154 pubmed publisher
    ..by Ptr2p/Ptr22p peptide transporters (PTR) and FMDP-containing hexa-, hepta-, and undecapeptide (F6, F7, and F11) were taken up by the oligopeptide transporters (OPT) oligopeptide permeases, preferably by Opt2p/Opt3p...
  80. Asakai R, Davie E, Chung D. Organization of the gene for human factor XI. Biochemistry. 1987;26:7221-8 pubmed
    Factor XI (plasma thromboplastin antecedent) is a plasma glycoprotein that participates in the early phase of blood coagulation. The gene for the human protein has been isolated from two different lambda phage genomic libraries...
  81. Fujikawa K, Chung D, Hendrickson L, Davie E. Amino acid sequence of human factor XI, a blood coagulation factor with four tandem repeats that are highly homologous with plasma prekallikrein. Biochemistry. 1986;25:2417-24 pubmed
    ..The amino acid sequence of factor XI shows 58% identity with human plasma prekallikrein. ..
  82. Renne T, Gailani D, Meijers J, Muller Esterl W. Characterization of the H-kininogen-binding site on factor XI: a comparison of factor XI and plasma prekallikrein. J Biol Chem. 2002;277:4892-9 pubmed
    Factor XI (FXI), the zymogen of the blood coagulation protease FXIa, and the structurally homologous protein plasma prekallikrein circulate in plasma in noncovalent complexes with H-kininogen (HK)...
  83. Aktimur A, Gabriel M, Gailani D, Toomey J. The factor IX gamma-carboxyglutamic acid (Gla) domain is involved in interactions between factor IX and factor XIa. J Biol Chem. 2003;278:7981-7 pubmed
    ..The data demonstrate that factor XIa binds with comparable affinity to factors IX and IXabeta and that the interactions are dependent on the factor IX Gla domain. ..
  84. Yun T, Baglia F, Myles T, Navaneetham D, Lopez J, Walsh P, et al. Thrombin activation of factor XI on activated platelets requires the interaction of factor XI and platelet glycoprotein Ib alpha with thrombin anion-binding exosites I and II, respectively. J Biol Chem. 2003;278:48112-9 pubmed
    Activation of factor XI (FXI) by thrombin on stimulated platelets plays a physiological role in hemostasis, providing additional thrombin generation required in cases of severe hemostatic challenge...
  85. Pedicord D, Seiffert D, Blat Y. Feedback activation of factor XI by thrombin does not occur in plasma. Proc Natl Acad Sci U S A. 2007;104:12855-60 pubmed
    In this study, we tested the hypothesis that factor XI (FXI) activation occurs in plasma following activation of the extrinsic pathway by thrombin-mediated feedback activation...
  86. Tomaiuolo M, Favuzzi G, Cappucci F, Pisanelli D, Tiscia G, Musto P, et al. Factor XI deficiency: two novel mutations in asymptomatic Italian patients. Haemophilia. 2010;16:767-70 pubmed publisher
    Factor XI (FXI) deficiency is a rare bleeding disorder, resulting in a wide range of bleeding manifestations, from asymptomatic bleeding to injury-related bleeding...
  87. Wong P, Jiang X. Apixaban, a direct factor Xa inhibitor, inhibits tissue-factor induced human platelet aggregation in vitro: comparison with direct inhibitors of factor VIIa, XIa and thrombin. Thromb Haemost. 2010;104:302-10 pubmed publisher
    ..Under these experimental conditions, a FXIa inhibitor did not prevent TF-induced platelet aggregation. ..
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  89. Kong M, Kim Y, Lee C. Functional investigation of a venous thromboembolism GWAS signal in a promoter region of coagulation factor XI gene. Mol Biol Rep. 2014;41:2015-9 pubmed publisher
    b>Coagulation factor XI (FXI) is essential for normal function of the intrinsic pathway of blood coagulation...
  90. Bruzelius M, Ljungqvist M, Bottai M, Bergendal A, Strawbridge R, Holmström M, et al. F11 is associated with recurrent VTE in women. A prospective cohort study. Thromb Haemost. 2016;115:406-14 pubmed publisher
    ..The genetic variants in F5 rs6025, F2 rs1799963, ABO rs514659, FGG rs2066865, F11 rs2289252, PROC rs1799810 and KNG1 rs710446 were assessed together with clinical variables...
  91. Olson N, Cushman M, Judd S, Kissela B, Safford M, Howard G, et al. Associations of coagulation factors IX and XI levels with incident coronary heart disease and ischemic stroke: the REGARDS study. J Thromb Haemost. 2017;15:1086-1094 pubmed publisher
    ..We studied associations of FIX and FXI with incident coronary heart disease (CHD) and stroke...
  92. Martin Fernandez L, Gavidia Bovadilla G, Corrales I, Brunel H, Ramírez L, Lopez S, et al. Next generation sequencing to dissect the genetic architecture of KNG1 and F11 loci using factor XI levels as an intermediate phenotype of thrombosis. PLoS ONE. 2017;12:e0176301 pubmed publisher
    ..There are significant associations among Factor XI (FXI) levels and SNPs in the KNG1 and F11 loci...