ezrin

Summary

Gene Symbol: ezrin
Description: ezrin
Alias: CVIL, CVL, HEL-S-105, VIL2, ezrin, cytovillin 2, epididymis secretory protein Li 105, p81, villin 2 (ezrin)
Species: human
Products:     ezrin

Top Publications

  1. Li Q, Wu M, Wang H, Xu G, Zhu T, Zhang Y, et al. Ezrin silencing by small hairpin RNA reverses metastatic behaviors of human breast cancer cells. Cancer Lett. 2008;261:55-63 pubmed
    b>Ezrin primarily acts as a linker between the plasma membrane and the cytoskeleton and is a key component in tumor metastasis...
  2. Gao S, Li E, Cui L, Lu X, Meng L, Yuan H, et al. Sp1 and AP-1 regulate expression of the human gene VIL2 in esophageal carcinoma cells. J Biol Chem. 2009;284:7995-8004 pubmed publisher
    b>Ezrin, encoded by VIL2, is a membrane-cytoskeletal linker protein that has been suggested to be involved in tumorigenesis...
  3. Bruce B, Khanna G, Ren L, Landberg G, Jirstrom K, Powell C, et al. Expression of the cytoskeleton linker protein ezrin in human cancers. Clin Exp Metastasis. 2007;24:69-78 pubmed
    Expression of the metastasis-associated protein, ezrin, in over 5,000 human cancers and normal tissues was analyzed using tissue microarray immunohistochemistry...
  4. Xie J, Xu L, Xie Y, Zhang H, Cai W, Zhou F, et al. Roles of ezrin in the growth and invasiveness of esophageal squamous carcinoma cells. Int J Cancer. 2009;124:2549-58 pubmed publisher
    b>Ezrin, which crosslinks the cytoskeleton and plasma membrane, is involved in the growth and metastatic potential of cancer cells...
  5. Valdman A, Fang X, Pang S, Nilsson B, Ekman P, Egevad L. Ezrin expression in prostate cancer and benign prostatic tissue. Eur Urol. 2005;48:852-7 pubmed
    The membrane-linking protein ezrin is highly expressed in several types of human cancers and correlations between its immunoreactivity and histopathological data as well as patient outcome have previously been shown...
  6. Di Cristofano C, Leopizzi M, Miraglia A, Sardella B, Moretti V, Ferrara A, et al. Phosphorylated ezrin is located in the nucleus of the osteosarcoma cell. Mod Pathol. 2010;23:1012-20 pubmed publisher
    The survival of osteosarcoma patients is connected to metastasis. The ezrin expression is associated with the development of metastasis and poor outcome in osteosarcoma...
  7. Khanna C, Wan X, Bose S, Cassaday R, Olomu O, Mendoza A, et al. The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis. Nat Med. 2004;10:182-6 pubmed
    ..From this genomic data, we selected ezrin for further study based on its role in physically and functionally connecting the actin cytoskeleton to the cell ..
  8. LaLonde D, Garbett D, Bretscher A. A regulated complex of the scaffolding proteins PDZK1 and EBP50 with ezrin contribute to microvillar organization. Mol Biol Cell. 2010;21:1519-29 pubmed publisher
    PDZK1 and ezrin, radixin, moesin binding phosphoprotein 50 kDa (EBP50) are postsynaptic density 95/disc-large/zona occludens (PDZ)-domain-containing scaffolding proteins found in the apical microvilli of polarized epithelial cells...
  9. Naba A, Reverdy C, Louvard D, Arpin M. Spatial recruitment and activation of the Fes kinase by ezrin promotes HGF-induced cell scattering. EMBO J. 2008;27:38-50 pubmed
    ..We previously showed that the membrane-cytoskeleton linker ezrin plays a major role in HGF-induced morphogenic effects...

More Information

Publications136 found, 100 shown here

  1. Barrero Villar M, Cabrero J, Gordón Alonso M, Barroso González J, Alvarez Losada S, Munoz Fernandez M, et al. Moesin is required for HIV-1-induced CD4-CXCR4 interaction, F-actin redistribution, membrane fusion and viral infection in lymphocytes. J Cell Sci. 2009;122:103-13 pubmed publisher
    ..lymphocytes, we have investigated whether HIV-1 Env might promote viral entry and infection by activating ERM (ezrin-radixin-moesin) proteins to regulate F-actin reorganization and CD4/CXCR4 co-clustering...
  2. Zaarour R, Chirivino D, Del Maestro L, Daviet L, Atfi A, Louvard D, et al. Ezrin ubiquitylation by the E3 ubiquitin ligase, WWP1, and consequent regulation of hepatocyte growth factor receptor activity. PLoS ONE. 2012;7:e37490 pubmed publisher
    The membrane cytoskeleton linker ezrin participates in several functions downstream of the receptor Met in response to Hepatocyte Growth Factor (HGF) stimulation...
  3. Yeh C, Pang S, Chen T, Wu R, Weng W, Chen M. Expression of ezrin is associated with invasion and dedifferentiation of hepatitis B related hepatocellular carcinoma. BMC Cancer. 2009;9:233 pubmed publisher
    ..This is the first study to determine the role of ezrin upon HBV HCC cell and patients with HBV HCC undergoing hepatectomy Immunohistochemical study with ezrin in 104 ..
  4. Prag S, Parsons M, Keppler M, Ameer Beg S, Barber P, Hunt J, et al. Activated ezrin promotes cell migration through recruitment of the GEF Dbl to lipid rafts and preferential downstream activation of Cdc42. Mol Biol Cell. 2007;18:2935-48 pubmed
    ..Here, we describe a novel role of the actin-binding ezrin/radixin/moesin (ERM)-protein ezrin to be involved in recruiting Cdc42, but not Rac1, to lipid raft microdomains, ..
  5. Zheng S, Huang J, Zhou K, Zhang C, Xiang Q, Tan Z, et al. 17?-Estradiol enhances breast cancer cell motility and invasion via extra-nuclear activation of actin-binding protein ezrin. PLoS ONE. 2011;6:e22439 pubmed publisher
    ..However, the detailed mechanism remains largely unknown. The actin binding protein ezrin is a key component in tumor metastasis and its over-expression is positively correlated to the poor outcome of ..
  6. Köbel M, Langhammer T, Huttelmaier S, Schmitt W, Kriese K, Dittmer J, et al. Ezrin expression is related to poor prognosis in FIGO stage I endometrioid carcinomas. Mod Pathol. 2006;19:581-7 pubmed
    As a cortical cytoskeletal protein, ezrin adapts the cytoplasmic tail of CD44 to the actin-based cytoskeleton and is functionally involved in migration and adhesion that are prerequisites for metastasis...
  7. Sarrio D, Rodriguez Pinilla S, Dotor A, Calero F, Hardisson D, Palacios J. Abnormal ezrin localization is associated with clinicopathological features in invasive breast carcinomas. Breast Cancer Res Treat. 2006;98:71-9 pubmed
    The membrane-cytoskeleton crosslinker ezrin is associated with malignant progression and metastasis in human neoplasias...
  8. Adyshev D, Moldobaeva N, Elangovan V, Garcia J, Dudek S. Differential involvement of ezrin/radixin/moesin proteins in sphingosine 1-phosphate-induced human pulmonary endothelial cell barrier enhancement. Cell Signal. 2011;23:2086-96 pubmed publisher
    ..In this study we explored the role of the ezrin, radixin, and moesin (ERM) family of actin-binding linker protein in modulating S1P-induced human pulmonary EC ..
  9. Jin J, Jin T, Quan M, Piao Y, Lin Z. Ezrin overexpression predicts the poor prognosis of gastric adenocarcinoma. Diagn Pathol. 2012;7:135 pubmed publisher
    b>Ezrin is a cytoskeletal protein that is involved in tumor growth and invasion. It has been suggested that Ezrin expression plays an important role in tumor metastasis...
  10. Kuo W, Yang K, Hsieh S, Lai M. Ezrin is a negative regulator of death receptor-induced apoptosis. Oncogene. 2010;29:1374-83 pubmed publisher
    b>Ezrin links cortical actin filaments with the cell membrane, and has a critical role in many membrane-initiated events...
  11. Zhou B, Leng J, Hu M, Zhang L, Wang Z, Liu D, et al. Ezrin is a key molecule in the metastasis of MOLT4 cells induced by CCL25/CCR9. Leuk Res. 2010;34:769-76 pubmed publisher
    Chemokines and their corresponding receptors participate in transmigration of leukemic cells. ERM (ezrin/radixin/moesin) protein family act as linkers between the plasma membrane and the cytoskeleton and are key component in tumor ..
  12. ten Klooster J, Jansen M, Yuan J, Oorschot V, Begthel H, Di Giacomo V, et al. Mst4 and Ezrin induce brush borders downstream of the Lkb1/Strad/Mo25 polarization complex. Dev Cell. 2009;16:551-62 pubmed publisher
    ..As an essential event in brush border formation, Mst4 phosphorylates the regulatory T567 residue of Ezrin. These data define a brush border induction pathway downstream of the Lkb1/Strad/Mo25 polarization complex, yet ..
  13. Yun C, Lamprecht G, Forster D, Sidor A. NHE3 kinase A regulatory protein E3KARP binds the epithelial brush border Na+/H+ exchanger NHE3 and the cytoskeletal protein ezrin. J Biol Chem. 1998;273:25856-63 pubmed
    ..As shown earlier for the human homolog of NHERF, we also found that the cytoskeletal protein ezrin binds to the carboxyl-terminal domain of E3KARP...
  14. Martin T, Harrison G, Mansel R, Jiang W. The role of the CD44/ezrin complex in cancer metastasis. Crit Rev Oncol Hematol. 2003;46:165-86 pubmed
    ..This molecule is known to interact with the ezrin family (ERM family) members and form a complex that plays diverse roles within both normal and abnormal cells, ..
  15. Yu Y, Khan J, Khanna C, Helman L, Meltzer P, Merlino G. Expression profiling identifies the cytoskeletal organizer ezrin and the developmental homeoprotein Six-1 as key metastatic regulators. Nat Med. 2004;10:175-81 pubmed
    ..Subsequent in vivo functional studies revealed that the actin filament-plasma membrane linker ezrin (encoded by Vil2) and the homeodomain-containing transcription factor Six-1 (sine oculis-related homeobox-1 ..
  16. Xu Dong S, Zan S, Shui er Z, Li na T, Wen xi Y, Feng L, et al. Expression of Ezrin correlates with lung metastasis in Chinese patients with osteosarcoma. Clin Invest Med. 2009;32:E180-8 pubmed
    To determine the prognostic value of the expression of Ezrin, CD44 and Six1 genes in osteosarcoma tissues of Chinese patients...
  17. Granes F, Berndt C, Roy C, Mangeat P, Reina M, Vilaró S. Identification of a novel Ezrin-binding site in syndecan-2 cytoplasmic domain. FEBS Lett. 2003;547:212-6 pubmed
    ERM (Ezrin/Radixin/Moesin) proteins are crosslinkers between plasma membrane proteins and the actin cytoskeleton, thereby involved in the formation of cell adhesion sites...
  18. Cant S, Pitcher J. G protein-coupled receptor kinase 2-mediated phosphorylation of ezrin is required for G protein-coupled receptor-dependent reorganization of the actin cytoskeleton. Mol Biol Cell. 2005;16:3088-99 pubmed
    ..Here, we identify ezrin as a novel non-GPCR substrate of GRK2...
  19. Ma L, Jiang T. Clinical implications of Ezrin and CD44 co?expression in breast cancer. Oncol Rep. 2013;30:1899-905 pubmed publisher
    ..aim of the present study was to investigate the expression status and clinical implications of the stem cell genes Ezrin and CD44 in breast cancers...
  20. Deng X, Tannehill Gregg S, Nadella M, He G, Levine A, Cao Y, et al. Parathyroid hormone-related protein and ezrin are up-regulated in human lung cancer bone metastases. Clin Exp Metastasis. 2007;24:107-19 pubmed
    ..Five of the nine up-regulated genes, including caveolin 1, CD44, EphB2, ezrin, and Parathyroid hormone-related protein (PTHrP), and one down-regulated gene, SLPI, were further confirmed by ..
  21. Brambilla D, Zamboni S, Federici C, Lugini L, Lozupone F, De Milito A, et al. P-glycoprotein binds to ezrin at amino acid residues 149-242 in the FERM domain and plays a key role in the multidrug resistance of human osteosarcoma. Int J Cancer. 2012;130:2824-34 pubmed publisher
    ..The cytoskeleton linker ezrin exerts a pivotal role in maintaining the functional connection between actin and Pgp...
  22. Ren L, Hong S, Cassavaugh J, Osborne T, Chou A, Kim S, et al. The actin-cytoskeleton linker protein ezrin is regulated during osteosarcoma metastasis by PKC. Oncogene. 2009;28:792-802 pubmed publisher
    b>Ezrin is a member of the ERM (ezrin, radixin, moesin) protein family and links F-actin to the cell membrane following phosphorylation...
  23. Chen Y, Wang D, Guo Z, Zhao J, Wu B, Deng H, et al. Rho kinase phosphorylation promotes ezrin-mediated metastasis in hepatocellular carcinoma. Cancer Res. 2011;71:1721-9 pubmed publisher
    ..In particular, we found that Thr567 hyperphosphorylation of the cytoskeletal protein ezrin was tightly correlated to an invasive phenotype of clinical hepatocellular carcinomas and to poor outcomes in ..
  24. Ivetic A, Deka J, Ridley A, Ager A. The cytoplasmic tail of L-selectin interacts with members of the Ezrin-Radixin-Moesin (ERM) family of proteins: cell activation-dependent binding of Moesin but not Ezrin. J Biol Chem. 2002;277:2321-9 pubmed
    ..By using this approach, members of the Ezrin-Radixin-Moesin family of proteins were found to interact specifically with the cytoplasmic tail of L-selectin...
  25. Lankes W, Furthmayr H. Moesin: a member of the protein 4.1-talin-ezrin family of proteins. Proc Natl Acad Sci U S A. 1991;88:8297-301 pubmed
    ..In addition, the protein shows significant sequence identity (72%) to ezrin (cytovillin, p81), as well as similarity to protein 4.1 and talin...
  26. Polesello C, Delon I, Valenti P, Ferrer P, Payre F. Dmoesin controls actin-based cell shape and polarity during Drosophila melanogaster oogenesis. Nat Cell Biol. 2002;4:782-9 pubmed
    b>Ezrin, Radixin and Moesin (ERM) proteins are thought to constitute a bridge between the actin cytoskeleton and the plasma membrane (PM). Here we report a genetic analysis of Dmoesin, the sole member of the ERM family in Drosophila...
  27. Urzainqui A, Serrador J, Viedma F, Yanez Mo M, Rodriguez A, Corbi A, et al. ITAM-based interaction of ERM proteins with Syk mediates signaling by the leukocyte adhesion receptor PSGL-1. Immunity. 2002;17:401-12 pubmed
    ..This association is mediated by the actin-linking proteins moesin and ezrin, which directly interact with Syk in an ITAM-dependent manner...
  28. Morales F, Takahashi Y, Momin S, Adams H, Chen X, Georgescu M. NHERF1/EBP50 head-to-tail intramolecular interaction masks association with PDZ domain ligands. Mol Cell Biol. 2007;27:2527-37 pubmed
    ..homologous adaptors 1 and 2 are membrane-associated proteins composed of two amino (N)-terminal PDZ domains and an ezrin-radixin-moesin (ERM)-binding (EB) carboxyl (C)-terminal region...
  29. Patara M, Santos E, Coudry R, Soares F, Ferreira F, Rossi B. Ezrin expression as a prognostic marker in colorectal adenocarcinoma. Pathol Oncol Res. 2011;17:827-33 pubmed publisher
    b>Ezrin protein acts in the regulation of cytoskeletal and directly influences survival and tumor progression; there is an increase in its expression in metastatic cells and tissues in several types of cancer including colorectal cancer...
  30. Gloerich M, ten Klooster J, Vliem M, Koorman T, Zwartkruis F, Clevers H, et al. Rap2A links intestinal cell polarity to brush border formation. Nat Cell Biol. 2012;14:793-801 pubmed publisher
    ..PDZGEF, the small G protein Rap2A, its effector TNIK, the kinase MST4 and, ultimately, the actin-binding protein Ezrin. Thus, epithelial cell polarization is translated directly into the acquisition of brush borders through a small G ..
  31. Andreoli C, Martin M, Le Borgne R, Reggio H, Mangeat P. Ezrin has properties to self-associate at the plasma membrane. J Cell Sci. 1994;107 ( Pt 9):2509-21 pubmed
    b>Ezrin, a member of a family of proteins involved in the interaction of the microfilament cytoskeleton with the plasma membrane, plays a role in membrane translocation in gastric parietal cells (Hanzel, D., Reggio, H., Bretscher, A...
  32. Heiska L, Alfthan K, Grönholm M, Vilja P, Vaheri A, Carpen O. Association of ezrin with intercellular adhesion molecule-1 and -2 (ICAM-1 and ICAM-2). Regulation by phosphatidylinositol 4, 5-bisphosphate. J Biol Chem. 1998;273:21893-900 pubmed
    b>Ezrin is a cytoplasmic linker molecule between plasma membrane components and the actin-containing cytoskeleton. We studied whether ezrin is associated with intercellular adhesion molecule (ICAM)-1, -2, and -3...
  33. Berryman M, Bretscher A. Identification of a novel member of the chloride intracellular channel gene family (CLIC5) that associates with the actin cytoskeleton of placental microvilli. Mol Biol Cell. 2000;11:1509-21 pubmed
    ..as a component of a multimeric complex consisting of several known cytoskeletal proteins, including actin, ezrin, alpha-actinin, gelsolin, and IQGAP1...
  34. Park H, Jung W, Bacchini P, Bertoni F, Kim Y, Park Y. Ezrin in osteosarcoma: comparison between conventional high-grade and central low-grade osteosarcoma. Pathol Res Pract. 2006;202:509-15 pubmed
    b>Ezrin is a cytoskeleton linker protein that is actively involved in the regulation of growth and metastatic capacity of cancer cells...
  35. Sizemore S, Cicek M, Sizemore N, Ng K, Casey G. Podocalyxin increases the aggressive phenotype of breast and prostate cancer cells in vitro through its interaction with ezrin. Cancer Res. 2007;67:6183-91 pubmed
    ..increases cancer aggressiveness remains poorly understood but may involve the interaction of podocalyxin with ezrin, an established mediator of metastasis...
  36. Endo K, Kondo S, Shackleford J, Horikawa T, Kitagawa N, Yoshizaki T, et al. Phosphorylated ezrin is associated with EBV latent membrane protein 1 in nasopharyngeal carcinoma and induces cell migration. Oncogene. 2009;28:1725-35 pubmed publisher
    ..Recently, the membrane crosslinker protein, ezrin, has been implicated in tumor cell metastasis and malignant progression...
  37. Li J, Tu Y, Wen J, Yao F, Wei W, Sun S. Role for ezrin in breast cancer cell chemotaxis to CCL5. Oncol Rep. 2010;24:965-71 pubmed
    This study was undertaken to observe the effects and the possible mechanism of membrane-cytoskeleton linker ezrin on the chemokine CC chemokine ligand 5 (CCL5)-induced invasive ability in human breast carcinoma MCF-7 cells...
  38. Huang H, Xiao Y, Lin H, Fu D, Zhan Z, Liang L, et al. Increased phosphorylation of ezrin/radixin/moesin proteins contributes to proliferation of rheumatoid fibroblast-like synoviocytes. Rheumatology (Oxford). 2011;50:1045-53 pubmed publisher
    Increasing evidence indicates that ezrin/radixin/moesin (ERM) proteins may play a critical role in cell proliferation...
  39. Zhang X, Chen G, Wu T, Yan J, Zhou J. Expression and clinical significance of ezrin in non--small-cell lung cancer. Clin Lung Cancer. 2012;13:196-204 pubmed publisher
    b>Ezrin is known to regulate cellular survival, adhesion, migration, and invasion and has been identified as 1 of the key components of tumor progression and metastasis...
  40. Fidalgo M, Guerrero A, Fraile M, Iglesias C, Pombo C, Zalvide J. Adaptor protein cerebral cavernous malformation 3 (CCM3) mediates phosphorylation of the cytoskeletal proteins ezrin/radixin/moesin by mammalian Ste20-4 to protect cells from oxidative stress. J Biol Chem. 2012;287:11556-65 pubmed publisher
    ..that it is involved in a novel response to oxidative stress that results in phosphorylation and activation of the ezrin/radixin/moesin (ERM) family of proteins...
  41. Arslan A, Silvera D, Arju R, Giashuddin S, Belitskaya Levy I, Formenti S, et al. Atypical ezrin localization as a marker of locally advanced breast cancer. Breast Cancer Res Treat. 2012;134:981-8 pubmed publisher
    ..of breast tumors of known stage, grade, and key clinical-pathological parameters for the expression of the protein ezrin, which is involved in promoting signaling of the PI3K-Akt-mTOR pathway in response to extracellular and tumor ..
  42. Straub B, Boda J, Kuhn C, Schnoelzer M, Korf U, Kempf T, et al. A novel cell-cell junction system: the cortex adhaerens mosaic of lens fiber cells. J Cell Sci. 2003;116:4985-95 pubmed
    ..The other complex contains ezrin, periplakin, periaxin and desmoyokin (and so is called the EPPD complex), usually together with moesin, spectrin(s)..
  43. Chambers D, Bretscher A. Ezrin mutants affecting dimerization and activation. Biochemistry. 2005;44:3926-32 pubmed
    ERM (ezrin/radixin/moesin) proteins provide a regulated linkage between membrane-associated proteins and the actin cytoskeleton...
  44. Wei Y, Li C, Yu S, Chou F, Fang F, Eng H, et al. Ezrin overexpression in gastrointestinal stromal tumors: an independent adverse prognosticator associated with the non-gastric location. Mod Pathol. 2009;22:1351-60 pubmed publisher
    b>Ezrin, a member of the ezrin-radixin-moesin family, acts as a link between the cell membrane and actin cytoskeleton to integrate cell adhesion-mediated signaling...
  45. Ferrari S, Zanella L, Alberghini M, Palmerini E, Staals E, Bacchini P. Prognostic significance of immunohistochemical expression of ezrin in non-metastatic high-grade osteosarcoma. Pediatr Blood Cancer. 2008;50:752-6 pubmed
    b>Ezrin is a membrane-cytoskeleton linker protein involved in regulating growth and metastatic behaviour of cancer cells. The study evaluated ezrin expression and its prognostic value in patients with non-metastatic osteosarcoma...
  46. Cui Y, Wu J, Zong M, Song G, Jia Q, Jiang J, et al. Proteomic profiling in pancreatic cancer with and without lymph node metastasis. Int J Cancer. 2009;124:1614-21 pubmed publisher
    ..Four differently regulated proteins, ezrin, radixin, moesin, and c14orf166, were selected for further validation by Western blot and immunohistochemistry...
  47. Fan L, Chen D, Lan C, Liu K, Fang D. Knockdown of ezrin via RNA interference suppresses Helicobacter pylori-enhanced invasion of gastric cancer cells. Cancer Biol Ther. 2011;11:746-52 pubmed
    ..b>Ezrin, a membrane cytoskeletal crosslinker protein, is well documented to regulate cell adhesion and cell motility...
  48. Wang L, Lin G, Jiang X, Lu Y. Expression of ezrin correlates with poor prognosis of nasopharyngeal carcinoma. Tumour Biol. 2011;32:707-12 pubmed publisher
    ..So, to find valuable prognostic factors becomes very important. To elucidate the expression of ezrin in NPC and its correlation with patients' clinicopathologic characteristics, time to progression, and overall ..
  49. Garzon Muvdi T, Schiapparelli P, Ap Rhys C, Guerrero Cazares H, Smith C, Kim D, et al. Regulation of brain tumor dispersal by NKCC1 through a novel role in focal adhesion regulation. PLoS Biol. 2012;10:e1001320 pubmed publisher
    ..Due to the ubiquitous expression of NKCC1 in mammalian tissues, its regulation by WNK kinases may serve as new therapeutic targets for GB aggressiveness and can be exploited by other highly invasive neoplasms. ..
  50. Gautreau A, Poullet P, Louvard D, Arpin M. Ezrin, a plasma membrane-microfilament linker, signals cell survival through the phosphatidylinositol 3-kinase/Akt pathway. Proc Natl Acad Sci U S A. 1999;96:7300-5 pubmed
    ERM (Ezrin-Radixin-Moesin) proteins function as plasma membrane-actin cytoskeleton linkers and participate in the formation of specialized domains of the plasma membrane...
  51. Huang H, Li C, Fang F, Tsai J, Li S, Lee Y, et al. Prognostic implication of ezrin overexpression in myxofibrosarcomas. Ann Surg Oncol. 2010;17:3212-9 pubmed publisher
    The bases of tumorigenesis, progression, and metastasis remain obscure in myxofibrosarcoma. As a member of ezrin-radixin-moesin family, ezrin acts as a link between the cell membrane and actin cytoskeleton to integrate cell adhesion-..
  52. Auvinen E, Carpen O, Korpela T, Rönty M, Vaheri A, Tarkkanen J. Altered expression of ezrin, E-Cadherin and ?-Catenin in cervical neoplasia. Neoplasma. 2013;60:56-61 pubmed publisher
    ..The crucial plasma membrane - cytoskeleton linker protein ezrin of the Ezrin-Radixin-Moesin (ERM) protein family is involved in the regulation of cell morphology, cell adhesion ..
  53. Takahashi K, Sasaki T, Mammoto A, Takaishi K, Kameyama T, Tsukita S, et al. Direct interaction of the Rho GDP dissociation inhibitor with ezrin/radixin/moesin initiates the activation of the Rho small G protein. J Biol Chem. 1997;272:23371-5 pubmed
    ..We have reported that the Rho subfamily members regulate the ezrin/radixin/moesin (ERM)-CD44 system, implicated in reorganization of actin filaments...
  54. Shcherbina A, Bretscher A, Kenney D, REMOLD O DONNELL E. Moesin, the major ERM protein of lymphocytes and platelets, differs from ezrin in its insensitivity to calpain. FEBS Lett. 1999;443:31-6 pubmed
    The ERM proteins, ezrin, radixin and moesin, provide regulated linkage of the cytoskeleton with the plasma membrane, particularly in cell surface projections...
  55. Legg J, Lewis C, Parsons M, Ng T, Isacke C. A novel PKC-regulated mechanism controls CD44 ezrin association and directional cell motility. Nat Cell Biol. 2002;4:399-407 pubmed
    ..chemotaxis assays we show that phosphorylation of Ser291 modulates the interaction between CD44 and the cytoskeletal linker protein ezrin in vivo, and that this phosphorylation is critical for CD44-dependent directional cell motility.
  56. Salas S, Bartoli C, Deville J, Gaudart J, Fina F, Calisti A, et al. Ezrin and alpha-smooth muscle actin are immunohistochemical prognostic markers in conventional osteosarcomas. Virchows Arch. 2007;451:999-1007 pubmed
    b>Ezrin is a cytoskeleton linker protein that is actively involved in the metastatic process of cancer cells...
  57. Elzagheid A, Korkeila E, Bendardaf R, Buhmeida A, Heikkilä S, Vaheri A, et al. Intense cytoplasmic ezrin immunoreactivity predicts poor survival in colorectal cancer. Hum Pathol. 2008;39:1737-43 pubmed publisher
    b>Ezrin is a membrane-cytoskeleton anchor, which, in experimental models, regulates tumor cell invasion and metastatic ability...
  58. Palou J, Algaba F, Vera I, Rodriguez O, Villavicencio H, Sanchez Carbayo M. Protein expression patterns of ezrin are predictors of progression in T1G3 bladder tumours treated with nonmaintenance bacillus Calmette-Guérin. Eur Urol. 2009;56:829-36 pubmed publisher
    ..However, it is not clear yet which patients are more likely to be responders to BCG. To evaluate the role of ezrin expression in bladder cancer (BCa) progression in T1G3 bladder tumours treated with BCG...
  59. Abdou A, Maraee A, El Sayed E, Elnaidany N. Immunohistochemical expression of ezrin in cutaneous basal and squamous cell carcinomas. Ann Diagn Pathol. 2011;15:394-401 pubmed publisher
    b>Ezrin is a member of the ezrin-radixin-moesin family of proteins, which link the actin-containing cytoskeleton to the plasma membrane. Overexpression of ezrin protein is correlated with the metastatic potential in several cancers...
  60. Reczek D, Berryman M, Bretscher A. Identification of EBP50: A PDZ-containing phosphoprotein that associates with members of the ezrin-radixin-moesin family. J Cell Biol. 1997;139:169-79 pubmed
    Members of the ezrin-radixin-moesin (ERM) family of membrane-cytoskeletal linking proteins have NH2- and COOH-terminal domains that associate with the plasma membrane and the actin cytoskeleton, respectively...
  61. Wang G, Mao W, Zheng S. MicroRNA-183 regulates Ezrin expression in lung cancer cells. FEBS Lett. 2008;582:3663-8 pubmed publisher
    ..Mechanistically, we identified VIL2-coding-protein Ezrin as a bona fide target of miR-183...
  62. Belkina N, Liu Y, Hao J, Karasuyama H, Shaw S. LOK is a major ERM kinase in resting lymphocytes and regulates cytoskeletal rearrangement through ERM phosphorylation. Proc Natl Acad Sci U S A. 2009;106:4707-12 pubmed publisher
    ERM (ezrin-radixin-moesin) proteins mediate linkage of actin cytoskeleton to plasma membrane in many cells...
  63. Zhao J, Zhang X, Xin Y. Up-regulated expression of Ezrin and c-Met proteins are related to the metastasis and prognosis of gastric carcinomas. Histol Histopathol. 2011;26:1111-20 pubmed publisher
    Recent publications demonstrated that abnormal expression of Ezrin and c-Met proteins were related to carcinogenesis, metastasis and prognosis of various sorts of tumors...
  64. Donatello S, Babina I, Hazelwood L, Hill A, Nabi I, Hopkins A. Lipid raft association restricts CD44-ezrin interaction and promotion of breast cancer cell migration. Am J Pathol. 2012;181:2172-87 pubmed publisher
    ..We describe a novel mechanism whereby rafts regulate interactions between CD44 and its binding partner ezrin in migrating breast cancer cells...
  65. Xie J, Xu L, Wu Z, Zhao Q, Xu X, Wu J, et al. Prognostic implication of ezrin expression in esophageal squamous cell carcinoma. J Surg Oncol. 2011;104:538-43 pubmed publisher
    b>Ezrin, a member of the ezrin-radixin-moesin family, was implicated in tumor progression, metastatic dissemination, and adverse outcomes in several cancer types, including esophageal squamous cell carcinoma (ESCC)...
  66. Dransfield D, Bradford A, Smith J, Martin M, Roy C, Mangeat P, et al. Ezrin is a cyclic AMP-dependent protein kinase anchoring protein. EMBO J. 1997;16:35-43 pubmed
    ..The purified 78 kDa AKAP was recognized by monoclonal antibodies against ezrin, the canalicular actin-associated protein...
  67. Serrador J, Nieto M, Alonso Lebrero J, del Pozo M, Calvo J, Furthmayr H, et al. CD43 interacts with moesin and ezrin and regulates its redistribution to the uropods of T lymphocytes at the cell-cell contacts. Blood. 1998;91:4632-44 pubmed
    ..Immunofluorescence analysis showed that all three ezrin-radixin-moesin (ERM) actin-binding proteins localized in the uropod of both human T lymphoblasts stimulated with ..
  68. Bretscher A, Edwards K, Fehon R. ERM proteins and merlin: integrators at the cell cortex. Nat Rev Mol Cell Biol. 2002;3:586-99 pubmed
    ..The ezrin-radixin-moesin (ERM) proteins are crucial components that provide a regulated linkage between membrane proteins ..
  69. Coscoy S, Waharte F, Gautreau A, Martin M, Louvard D, Mangeat P, et al. Molecular analysis of microscopic ezrin dynamics by two-photon FRAP. Proc Natl Acad Sci U S A. 2002;99:12813-8 pubmed
    b>Ezrin plays a key role in coupling signal transduction to cortical cell organization...
  70. Wu K, Khan S, Lakhe Reddy S, Jarad G, Mukherjee A, Obejero Paz C, et al. The NHE1 Na+/H+ exchanger recruits ezrin/radixin/moesin proteins to regulate Akt-dependent cell survival. J Biol Chem. 2004;279:26280-6 pubmed
    ..In addition to mediating Na(+)/H(+) transport, NHE1 interacts with ezrin/radixin/moesin (ERM), which tethers NHE1 to cortical actin cytoskeleton to regulate cell shape, adhesion, motility,..
  71. Ivetic A, Florey O, Deka J, Haskard D, Ager A, Ridley A. Mutagenesis of the ezrin-radixin-moesin binding domain of L-selectin tail affects shedding, microvillar positioning, and leukocyte tethering. J Biol Chem. 2004;279:33263-72 pubmed
    ..We have previously identified ezrin and moesin as novel binding partners of the 17-amino acid L-selectin tail, but the biological role of this ..
  72. Stanasila L, Abuin L, Diviani D, Cotecchia S. Ezrin directly interacts with the alpha1b-adrenergic receptor and plays a role in receptor recycling. J Biol Chem. 2006;281:4354-63 pubmed
    Using the yeast two-hybrid system, we identified ezrin as a protein interacting with the C-tail of the alpha1b-adrenergic receptor (AR)...
  73. Köbel M, Gradhand E, Zeng K, Schmitt W, Kriese K, Lantzsch T, et al. Ezrin promotes ovarian carcinoma cell invasion and its retained expression predicts poor prognosis in ovarian carcinoma. Int J Gynecol Pathol. 2006;25:121-30 pubmed
    ..This consists of ezrin, radixin, and moesin and connects the CD44 receptor with the cytoskeleton...
  74. Gupta N, Wollscheid B, Watts J, Scheer B, Aebersold R, DeFranco A. Quantitative proteomic analysis of B cell lipid rafts reveals that ezrin regulates antigen receptor-mediated lipid raft dynamics. Nat Immunol. 2006;7:625-33 pubmed
    ..BCR engagement induced dissociation of the adaptor protein ezrin from lipid rafts as well as threonine dephosphorylation of ezrin and its concomitant detachment from actin, ..
  75. Krishnan K, Bruce B, Hewitt S, Thomas D, Khanna C, Helman L. Ezrin mediates growth and survival in Ewing's sarcoma through the AKT/mTOR, but not the MAPK, signaling pathway. Clin Exp Metastasis. 2006;23:227-36 pubmed
    Recent reports on the role of the membrane-cytoskeleton linker protein ezrin in sarcomas showed an effect on the formation of metastases, dependent on the level of ezrin expression...
  76. Hebert M, Potin S, Sebbagh M, Bertoglio J, Bréard J, Hamelin J. Rho-ROCK-dependent ezrin-radixin-moesin phosphorylation regulates Fas-mediated apoptosis in Jurkat cells. J Immunol. 2008;181:5963-73 pubmed
    ..It has been shown that ezrin, a member of the ERM (ezrin-radixin-moesin) protein family can link Fas to the actin cytoskeleton...
  77. Li J, Callaway D, Bu Z. Ezrin induces long-range interdomain allostery in the scaffolding protein NHERF1. J Mol Biol. 2009;392:166-80 pubmed publisher
    ..This CT domain binds to ezrin, which, in turn, interacts with cytosekeletal actin...
  78. Wang Y, Shen J, Xie X, Wang J, Huang G. Expression change of ezrin as a prognostic factor in primary osteosarcoma. Med Oncol. 2011;28 Suppl 1:S636-43 pubmed publisher
    Osteosarcoma is a life-threatening malignancy that most often occurs in teenagers. Ezrin is a cytoskeleton linker protein that is actively involved in the metastatic capacity of cancer cells...
  79. Korkeila E, Syrjanen K, Bendardaf R, Laulajainen M, Carpen O, Pyrhonen S, et al. Preoperative radiotherapy modulates ezrin expression and its value as a predictive marker in patients with rectal cancer. Hum Pathol. 2011;42:384-92 pubmed publisher
    The purpose of this study was to assess the value of ezrin expression as a predictor of disease outcome in rectal cancer treated by preoperative radio- or chemoradiotherapy...
  80. Athanasopoulou A, Aroukatos P, Nakas D, Repanti M, Papadaki H, Bravou V. Decreased ezrin and paxillin expression in human urothelial bladder tumors correlate with tumor progression. Urol Oncol. 2013;31:836-42 pubmed publisher
    F-actin binding proteins ezrin and paxillin are involved in cell adhesion and cell migration/invasion. The aim of the study was to investigate their role in urothelial bladder carcinogenesis.
  81. Oda Y, Aishima S, Morimatsu K, Hayashi A, Shindo K, Fujino M, et al. Differential ezrin and phosphorylated ezrin expression profiles between pancreatic intraepithelial neoplasia, intraductal papillary mucinous neoplasm, and invasive ductal carcinoma of the pancreas. Hum Pathol. 2013;44:1487-98 pubmed publisher
    ..b>Ezrin is a member of the ezrin, radixin, and moesin protein family and acts as a cross-linker between the plasma ..
  82. Gary R, Bretscher A. Ezrin self-association involves binding of an N-terminal domain to a normally masked C-terminal domain that includes the F-actin binding site. Mol Biol Cell. 1995;6:1061-75 pubmed
    b>Ezrin is a membrane-cytoskeletal linking protein that is concentrated in actin-rich surface structures. It is closely related to the microvillar proteins radixin and moesin and to the tumor suppressor merlin/schwannomin...
  83. Tran Quang C, Gautreau A, Arpin M, Treisman R. Ezrin function is required for ROCK-mediated fibroblast transformation by the Net and Dbl oncogenes. EMBO J. 2000;19:4565-76 pubmed
    ..We investigated the role of the cytoskeletal linker protein ezrin in this process...
  84. Reczek D, Bretscher A. Identification of EPI64, a TBC/rabGAP domain-containing microvillar protein that binds to the first PDZ domain of EBP50 and E3KARP. J Cell Biol. 2001;153:191-206 pubmed
    ..EPI64 colocalizes with EBP50 and ezrin in syncytiotrophoblast and cultured cell microvilli, and this localization in cultured cells is abolished by ..
  85. Serrador J, Vicente Manzanares M, Calvo J, Barreiro O, Montoya M, Schwartz Albiez R, et al. A novel serine-rich motif in the intercellular adhesion molecule 3 is critical for its ezrin/radixin/moesin-directed subcellular targeting. J Biol Chem. 2002;277:10400-9 pubmed
    ..We have investigated the interaction between ICAM-3 and ezrin/radixin/moesin (ERM) proteins and its role in LFA-1-induced cell-cell interactions and membrane positioning of ..
  86. Smith W, Nassar N, Bretscher A, Cerione R, Karplus P. Structure of the active N-terminal domain of Ezrin. Conformational and mobility changes identify keystone interactions. J Biol Chem. 2003;278:4949-56 pubmed
    b>Ezrin is a member of the ERM (ezrin, radixin, moesin) family of proteins that cross-link the actin cytoskeleton to the plasma membrane and also may function in signaling cascades that regulate the assembly of actin stress fibers...
  87. Srivastava J, Elliott B, Louvard D, Arpin M. Src-dependent ezrin phosphorylation in adhesion-mediated signaling. Mol Biol Cell. 2005;16:1481-90 pubmed
    In addition to providing a regulated linkage between the membrane and the actin cytoskeleton, ezrin participates in signal transduction pathways...
  88. Weng W, Ahlén J, Astrom K, Lui W, Larsson C. Prognostic impact of immunohistochemical expression of ezrin in highly malignant soft tissue sarcomas. Clin Cancer Res. 2005;11:6198-204 pubmed
    b>Ezrin is a cytoskeleton linker protein that is actively involved in regulating the growth and metastatic capacity of cancer cells. It has recently been reported to be involved in dissemination of pediatric soft tissue sarcoma (STS)...
  89. Chuan Y, Pang S, Cedazo Minguez A, Norstedt G, Pousette A, Flores Morales A. Androgen induction of prostate cancer cell invasion is mediated by ezrin. J Biol Chem. 2006;281:29938-48 pubmed
    b>Ezrin is a key signaling molecule that regulates cell survival, adhesion migration, and invasion...
  90. Haedicke J, De los Santos K, Goff S, Naghavi M. The Ezrin-radixin-moesin family member ezrin regulates stable microtubule formation and retroviral infection. J Virol. 2008;82:4665-70 pubmed publisher
    ..Here, we provide evidence that overexpression of ezrin, another closely related ezrin-radixin-moesin (ERM) family member, also blocks replication of both murine leukemia ..
  91. Saleh H, Merkel U, Geissler K, Sperka T, Sechi A, Breithaupt C, et al. Properties of an ezrin mutant defective in F-actin binding. J Mol Biol. 2009;385:1015-31 pubmed publisher
    b>Ezrin, radixin and moesin are a family of proteins that provide a link between the plasma membrane and the cortical actin cytoskeleton...
  92. Osawa H, Smith C, Ra Y, Kongkham P, Rutka J. The role of the membrane cytoskeleton cross-linker ezrin in medulloblastoma cells. Neuro Oncol. 2009;11:381-93 pubmed publisher
    ..The cytoskeletal protein ezrin was found to be overexpressed in medulloblastoma compared with normal cerebellum, an observation that was further ..