EXOSC6

Summary

Gene Symbol: EXOSC6
Description: exosome component 6
Alias: EAP4, MTR3, Mtr3p, hMtr3p, p11, exosome complex component MTR3, Mtr3 (mRNA transport regulator 3)-homolog, exosome complex exonuclease MTR3, hMtr3, homolog of yeast mRNA transport regulator 3, mRNA transport regulator 3 homolog
Species: human
Products:     EXOSC6

Top Publications

  1. Qing X, Qing A, Ji P, French S, Mason H. Mixed phenotype (T/B/myeloid) extramedullary blast crisis as an initial presentation of chronic myelogenous leukemia. Exp Mol Pathol. 2018;104:130-133 pubmed publisher
    ..2),+10,-15,add(17)(p11.2),+19, +der(22)t(9;22),+mar[cp8])...
  2. Barclay M, Constable R, James N, Thorne P, Montgomery J. Reduced sensory stimulation alters the molecular make-up of glutamatergic hair cell synapses in the developing cochlea. Neuroscience. 2016;325:50-62 pubmed publisher
    ..the sensory hair cells, by rupturing the tympanic membrane and dislocating the auditory ossicles in the left ear of P11 mice...
  3. Zhao M, Rao Q, Wu C, Zhao Z, He X, Ru G. Alveolar soft part sarcoma of lung: report of a unique case with emphasis on diagnostic utility of molecular genetic analysis for TFE3 gene rearrangement and immunohistochemistry for TFE3 antigen expression. Diagn Pathol. 2015;10:160 pubmed publisher
    ..The molecular signature of ASPS is a specific der(17)t(X;17)(p11.2;q25) translocation, which results in the fusion of TFE3 transcription factor gene at Xp11.2 with ASPL at 17q25...
  4. Zhang L, Hu X, Benedek D, Fullerton C, Forsten R, Naifeh J, et al. Genetic predictor of current suicidal ideation in US service members deployed to Iraq and Afghanistan. J Psychiatr Res. 2019;113:65-71 pubmed publisher
    ..neurotrophic factor (BDNF), FK506 binding protein (FKBP5), catechol-O-methyltransferase (COMT), or S100A10 (p11) were examined. We found CSI was associated with BDNF (OR = 1.5, 95% CI = 1.5-1.8, P = 0...
  5. Ren M, Qin H, Wu Q, Savage N, George T, Cowell J. Development of ZMYM2-FGFR1 driven AML in human CD34+ cells in immunocompromised mice. Int J Cancer. 2016;139:836-40 pubmed publisher
    ..The t(8;13)(p11;q12) chromosome translocation is most common rearrangement seen in this syndrome and creates a ZMYM2-FGFR1 chimeric ..
  6. Mitic M, Brkić Z, Lukic I, Adzic M. Convergence of glycogen synthase kinase 3β and GR signaling in response to fluoxetine treatment in chronically stressed female and male rats. Behav Brain Res. 2017;333:295-303 pubmed publisher
    ..Furthermore, fluoxetine reverted stress-induced changes in most of the analyzed genes in males, CRH, 5-HT1a and p11, while in females its effect was limited to CRH...
  7. Wheat W, Arthun E, Spencer J, Regan D, Titus R, Dow S. Immunization against full-length protein and peptides from the Lutzomyia longipalpis sand fly salivary component maxadilan protects against Leishmania major infection in a murine model. Vaccine. 2017;35:6611-6619 pubmed publisher
    ..Antisera from C-terminal peptide (P11) MAX-CLDC-vaccinated animals was capable of recognizing FL-MAX and its C-terminal domain and also blocked MAX-..
  8. Fry E, Inoue K. c-MYB and DMTF1 in Cancer. Cancer Invest. 2019;37:46-65 pubmed publisher
    ..overexpressed by translocation in human tumors with t(6;7)(q23;q34) resulting in c-MYB-TCRβ in T cell ALL, t(X;6)(p11;q23) with c-MYB-GATA1 in acute basophilic leukemia, and t(6;9)(q22-23;p23-24) with c-MYB-NF1B in adenoid cystic ..
  9. Buzalaf M, Pessan J. New Preventive Approaches Part I: Functional Peptides and Other Therapies to Prevent Tooth Demineralization. Monogr Oral Sci. 2017;26:88-96 pubmed publisher
    ..Other peptides include 8DSS, self-assembling peptide P11-4, antimicrobial peptides, and casein phosphopeptides combined with amorphous calcium phosphate...

More Information

Publications124 found, 100 shown here

  1. Wang J, Ding C, Zhang Y, Zeng Z, Hou X, Lu B, et al. [Preimplantation genetic diagnosis for carriers of thalassemia and chromosomal abnormality]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2016;33:1-4 pubmed publisher
    ..thalassemia mutations, while the husband has carried a reciprocal translocation with a karyotype of 46,XY,inv(9)(p11;q13),t(11;22)(q25;q13). Couple 2 were both carriers of α (-SEA) thalassemia mutation...
  2. Hao S, Long F, Sun F, Liu T, Li D, Jiang S. Birt-Hogg-Dubé syndrome: a literature review and case study of a Chinese woman presenting a novel FLCN mutation. BMC Pulm Med. 2017;17:43 pubmed publisher
    ..dominant form of genodermatosis caused by germline mutations in the folliculin (FLCN) gene, which is mapped to the p11.2 region in chromosome 17...
  3. Chang K, Liu J, Yu S, Lin C. FGFR1 translocation with concurrent myeloproliferative neoplasm, systemic mastocytosis, and lymphoblastic lymphoma: a case report. Hum Pathol. 2018;74:114-121 pubmed publisher
    ..The cytogenetic study, reverse-transcription polymerase chain reaction, and sequencing revealed t(8;13)(p11;q12) involving FGFR1 and ZMYM2...
  4. Nakano A, Nakahara T, Mori A, Ushikubo H, Sakamoto K, Ishii K. Short-term treatment with VEGF receptor inhibitors induces retinopathy of prematurity-like abnormal vascular growth in neonatal rats. Exp Eye Res. 2016;143:120-31 pubmed publisher
    ..The second round of KRN633 treatment on P11 and P12 completely blocked abnormal retinal vascular growth on P14, but thereafter induced ROP-like abnormal ..
  5. Zheng J, Chen T, Zhu Y, Li H, Deng X, Wang Q, et al. Liraglutide prevents fast weight gain and β-cell dysfunction in male catch-up growth rats. Exp Biol Med (Maywood). 2015;240:1165-76 pubmed publisher
    ..Pdx-1) and B-cell lymphoma-2 transcript and protein expression, and reduced Procaspase-3 transcript and Caspase-3 p11 subunit protein expression, suggesting that expression of Pdx-1 and reduction of apoptosis may be the mechanisms ..
  6. Alcaraz García P, Díaz Palacios S, Castillo Canto C, Gatica Pérez A, Sánchez González J. Primary pulmonary biphasic synovial sarcoma: a case report and literature review. Cir Cir. 2012;80:67-71 pubmed
    ..Cytogenetic characteristic of synovial sarcoma are t(X; 18)(p11, q11). Patient prognosis for pulmonary synovial sarcoma is poor with an overall 5-year survival rate of 50%.
  7. Chen G, Henter I, Manji H. Translational research in bipolar disorder: emerging insights from genetically based models. Mol Psychiatry. 2010;15:883-95 pubmed publisher
    ..synthase kinase 3beta (GSK-3beta), glutamate receptor 6 (GluR6), extracellular signal-regulated kinase-1 (ERK1), p11 (or S100A10), vesicular monoamine transporter 2 (VMAT2 or SLC18A2), glucocorticoid receptors (GRs), Bcl-2-..
  8. Qassid O, Ali A, Thway K. Synovial Sarcoma With Myoid Differentiation. Int J Surg Pathol. 2016;24:525-7 pubmed publisher
    ..mesenchymal tumor with variable epithelial differentiation, which is defined by the presence of a specific t(X;18)(p11.2;q11.2) chromosomal translocation that generates SS18-SSX fusion oncogenes...
  9. Chen C, Lin S, Chern S, Wu P, Chen S, Lai S, et al. A 13-year-old girl with 18p deletion syndrome presenting Turner syndrome-like clinical features of short stature, short webbed neck, low posterior hair line, puffy eyelids and increased carrying angle of the elbows. Taiwan J Obstet Gynecol. 2018;57:583-587 pubmed publisher
    ..Cytogenetic analysis of the girl revealed a karyotype of 46,XX,del(18) (p11.2). The parental karyotypes were normal...
  10. Sharma S, Sharma A, Lobo G, Nayak M, Pradhan D, Samriti -, et al. Primary dura-based synovial sarcoma of the parafalcine region of brain. Pathol Res Pract. 2017;213:868-871 pubmed publisher
    ..Fluorescence in situ hybridization confirmed tumor specific translocation t(X;18)(p11.2;q11.2). Hence, final diagnosis of synovial sarcoma was rendered...
  11. Ishiguro N, Yoshida H. ASPL-TFE3 Oncoprotein Regulates Cell Cycle Progression and Induces Cellular Senescence by Up-Regulating p21. Neoplasia. 2016;18:626-635 pubmed publisher
    ..It is characterized by the unbalanced recurrent chromosomal translocation der(17)t(X;17)(p11;q25), resulting in the generation of an ASPL-TFE3 fusion gene...
  12. Chen C, Ko T, Huang W, Chern S, Wu P, Chen Y, et al. Molecular cytogenetic characterization of inv dup del(8p) in a fetus associated with ventriculomegaly, hypoplastic left heart, polyhydramnios and intestinal obstruction. Taiwan J Obstet Gynecol. 2016;55:415-8 pubmed publisher
    ..35 Mb deletion in 8p23.3-p23.1 encompassing SOX7 and GATA4, and a 31.99 Mb duplication in 8p23.1-p11.1 in the fetus. Metaphase FISH confirmed inv dup del(8p). The fetus had a karyotype of 46,XX,der(8)del(8)(p23...
  13. Theodorou A, Phylactides M, Forti L, Cramarossa M, Spyrou P, Gambari R, et al. The investigation of resveratrol and analogs as potential inducers of fetal hemoglobin. Blood Cells Mol Dis. 2016;58:6-12 pubmed publisher
    ..Three derivatives (P1, P4 and P11) exhibited similar hemoglobin-inducing properties to resveratrol in K562 cells, however, only P11 showed reduced ..
  14. Chen C, Chiang S, Wang K, Cho F, Chen M, Chern S, et al. Prenatal diagnosis of mosaic small supernumerary marker chromosome 17 associated with ventricular septal defect, developmental delay, and speech delay. Taiwan J Obstet Gynecol. 2016;55:419-22 pubmed publisher
    ..QF-PCR assays excluded uniparental disomy 17. The marker chromosome was the sSMC(17) of der(17)(:p11.1?q11.2:). A 3004 g male baby was delivered at 38 weeks of gestation...
  15. Saitow F, Nagano M, Suzuki H. Developmental Changes in Serotonergic Modulation of GABAergic Synaptic Transmission and Postsynaptic GABAA Receptor Composition in the Cerebellar Nuclei. Cerebellum. 2018;17:346-358 pubmed publisher
    ..GABA release probabilities accordingly exhibited significant decreases from P11-13 to P19-21...
  16. Chen X, Dai M, Shi W, Pan Y, Zhang W, Zhang Y, et al. [Analysis of two false positive cases from noninvasive prenatal testing]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2014;31:778-81 pubmed publisher
    ..And the karyotype was 45,X[48]/46, X, der(X) del(X) (p11.21) del(X) (q13.3)[62]...
  17. Matsumoto Y, Taki T, Fujimoto Y, Taniguchi K, Shimizu D, Shimura K, et al. Monosomies 7p and 12p and FLT3 internal tandem duplication: possible markers for diagnosis of T/myeloid biphenotypic acute leukemia and its clonal evolution. Int J Hematol. 2009;89:352-358 pubmed publisher
    ..with T/myeloid biphenotypic acute leukemia showing clonal chromosomal and genetic abnormalities including dic(7;12)(p11;p11) and Fms-like tyrosine kinase 3 (FLT3)-internal tandem duplication...
  18. Chen J, Ruan Q, Shen Y, Wang S, Shao L, Zhang W. Assessing and screening for T-cell epitopes from Mycobacterium tuberculosis RD2 proteins for the diagnosis of active tuberculosis. Braz J Infect Dis. 2018;22:462-471 pubmed publisher
    ..The IFN-γ release responses to Rv1986-P9, P15, P16, Rv1988-P4, P11, and Rv1987-P11 were significantly higher in the active TB group than in the control groups (p<0.05)...
  19. Srikumar B, Paschapur M, Kalidindi N, Adepu B, Das M, Sreedhara M, et al. Characterization of the adrenocorticotrophic hormone - induced mouse model of resistance to antidepressant drug treatment. Pharmacol Biochem Behav. 2017;161:53-61 pubmed publisher
    ..To understand the mechanism responsible for the diminished response in these mice, we evaluated p11 (S100A10) mRNA expression and 5-HT2A protein expression...
  20. Damayanti N, Budka J, Khella H, Ferris M, Ku S, Kauffman E, et al. Therapeutic Targeting of TFE3/IRS-1/PI3K/mTOR Axis in Translocation Renal Cell Carcinoma. Clin Cancer Res. 2018;24:5977-5989 pubmed publisher
    ..The presence of a SFPQ-TFE3 fusion [t(X;1) (p11.2; p34)] with chromosomal break-points was identified by RNA-seq and validated by RT-PCR...
  21. Paillard C, Coulomb A, Helfre S, Orbach D. [Alveolar soft part sarcoma in pediatric patients]. Bull Cancer. 2015;102:792-8 pubmed publisher
    ..ASPS is characterized by an almost specific translocation t(X, 17)(p11;25) which creates a fusion protein, APSL-TFE3, acting as an aberrant transcription factor...
  22. Jones C, Alikhan M, O Reilly M, Sozo F, Williams T, Harding R, et al. The effect of CSF-1 administration on lung maturation in a mouse model of neonatal hyperoxia exposure. Respir Res. 2014;15:110 pubmed publisher
    ..CSF-1 increased CSF-1R+/F4/80+ macrophage number by 34% at P11 compared to Hyp + PBS, but was not associated with growth or lung structural rescue...
  23. Lei Y, Wang K, Li X, Li Y, Feng X, Zhou J, et al. Cell-surface Translocation of Annexin A2 contributes to bleomycin-induced pulmonary fibrosis by mediating inflammatory response in mice. Clin Sci (Lond). 2019;: pubmed publisher
    ..ANXA2 in lung epithelial cells through exosomal secretion, associated with enhanced interaction between ANXA2 and p11. Knockdown of ANXA2 or blocking membrane ANXA2 mitigated bleomycin-induced activation of NF-κB pathway and ..
  24. Renault A, Mebirouk N, Fuhrmann L, Bataillon G, Cavaciuti E, Le Gal D, et al. Morphology and genomic hallmarks of breast tumours developed by ATM deleterious variant carriers. Breast Cancer Res. 2018;20:28 pubmed publisher
    ..Losses at 13q14.11-q14.3, 17p13.2-p12, 21p11.2-p11.1 and 22q11.23 were observed...
  25. Kumar K, Chen W, Koduru P, Luu H. Myeloid and lymphoid neoplasm with abnormalities of FGFR1 presenting with trilineage blasts and RUNX1 rearrangement: a case report and review of literature. Am J Clin Pathol. 2015;143:738-48 pubmed publisher
    ..Cytogenetic and fluorescent in situ hybridization studies showed unique dual translocations of t(8;13)(p11.2;q12) and t(17;21)(p13;q22) with RUNX1 rearrangement...
  26. Goodwill H, Manzano Nieves G, Gallo M, Lee H, Oyerinde E, Serre T, et al. Early life stress leads to sex differences in development of depressive-like outcomes in a mouse model. Neuropsychopharmacology. 2019;44:711-720 pubmed publisher
    ..From P4 to P11, a limited bedding model that leads to fragmented maternal care, was used to induce ELS...
  27. Melzer C, von der Ohe J, Hass R, Ungefroren H. TGF-β-Dependent Growth Arrest and Cell Migration in Benign and Malignant Breast Epithelial Cells Are Antagonistically Controlled by Rac1 and Rac1b. Int J Mol Sci. 2017;18: pubmed publisher
    ..Senescent HMEC (P15/P16), when compared to their non-senescent counterparts (P11/P12), presented with dramatically increased migratory activity...
  28. Vistica D, Hollingshead M, Borgel S, Kenney S, Stockwin L, Raffeld M, et al. Therapeutic vulnerability of an in vivo model of alveolar soft part sarcoma (ASPS) to antiangiogenic therapy. J Pediatr Hematol Oncol. 2009;31:561-70 pubmed publisher
    ..3) nuclear staining with antibodies to the ASPL-TFE3 type 1 fusion protein, (4) maintenance of the t(X;17)(p11;q25) translocation characteristic of ASPS, (5) stable expression of signature ASPS gene transcripts and finally, ..
  29. Jablonski S, Graham D, Vorhees C, Williams M. Effects of Neonatal Methamphetamine and Stress on Brain Monoamines and Corticosterone in Preweanling Rats. Neurotox Res. 2017;31:269-282 pubmed publisher
    ..Rats were given 0 (saline), 5, or 7.5 mg/kg MA, four times per day from postnatal day (P)11 to 15 or P11 to 20. Half of the litters were reared in cages with standard bedding and half with no bedding...
  30. Garmendia A, Lopez W, Ortega N, Chamorro M. Molecular characterization of rotavirus isolated from alpaca (Vicugna pacos) crias with diarrhea in the Andean Region of Cusco, Peru. Vet Microbiol. 2015;180:109-12 pubmed publisher
    ..Molecular G and P typing, placed the former as G3/P11 and the latter as G3/P?...
  31. Jaber O, Kirby P. Alveolar Soft Part Sarcoma. Arch Pathol Lab Med. 2015;139:1459-62 pubmed publisher
    ..It is characterized by a specific chromosomal alteration, der(17)t(X:17)(p11:q25), resulting in fusion of the transcription factor E3 (TFE3) with alveolar soft part sarcoma critical region 1 (..
  32. Singh N, Sahu D, Goel M, Kant R, Gupta D. Retrospective analysis of FFPE based Wilms' Tumor samples through copy number and somatic mutation related Molecular Inversion Probe Based Array. Gene. 2015;565:295-308 pubmed publisher
    ..The identified LOH-regions (1q21.2-q21.3, 2p24.1-23.3, 2p24.3-24.3, 3p21.3-21.1, 4p16.3, 7p11.2-p11.1, 7q31.2-31.32, 7q34-q35 and Ch 8) in W1-W6 were also validated in W7-9, W12-15 and W18...
  33. Cheung K, Yung S, Chau M, Yap D, Chan K, Lee C, et al. Annexin II-binding immunoglobulins in patients with lupus nephritis and their correlation with disease manifestations. Clin Sci (Lond). 2017;131:653-671 pubmed publisher
    ..In NZBWF1/J mice, serum annexin II-binding IgG and IgM levels and glomerular annexin II and p11 expression increased with progression of active nephritis...
  34. Qiu X, Li F, Cao H, Shao J, Mei J, Li H, et al. Activity of fibroblast growth factor receptor inhibitors TKI258, ponatinib and AZD4547 against TPR?FGFR1 fusion. Mol Med Rep. 2017;15:1024-1030 pubmed publisher
    ..To date, four cases of EMS with the chromosomal translocation, t(1;8)(q25;p11.2), have been reported...
  35. Azevedo H, Amato Khaled N, Santos P, Bernardi Bertonha F, Moreira Filho C. Temporal analysis of hippocampal CA3 gene coexpression networks in a rat model of febrile seizures. Dis Model Mech. 2018;11: pubmed publisher
    ..These results suggest that HS trigger transcriptional alterations that could lead to persistent neurogenesis, tissue remodeling and inflammation in the CA3 hippocampus, making the brain prone to epileptic activity. ..
  36. Thanos P, Malave L, Delis F, Mangine P, Kane K, Grunseich A, et al. Knockout of p11 attenuates the acquisition and reinstatement of cocaine conditioned place preference in male but not in female mice. Synapse. 2016;70:293-301 pubmed publisher
    ..Here we examined the role of the protein p11, which recruits serotonin 5HT1B and 5HT4 receptors to the cell surface, in cocaine reward...
  37. Oliferenko S, Paiha K, Harder T, Gerke V, Schwärzler C, Schwarz H, et al. Analysis of CD44-containing lipid rafts: Recruitment of annexin II and stabilization by the actin cytoskeleton. J Cell Biol. 1999;146:843-54 pubmed
    ..Second, the formation of intracellular, submembranous annexin II-p11 aggregates caused by expression of a trans-dominant mutant of annexin II resulted in coclustering of CD44...
  38. Call M, Fischesser K, Lunn M, Kao W. A unique lineage gives rise to the meibomian gland. Mol Vis. 2016;22:168-76 pubmed
    ..Krt14), Krt15, Krt4, and Krt10, was examined with immunofluorescent staining of C57BL/6J mouse eyelids from P2 to P11 pups and adult mice...
  39. Zerkalenkova E, Panfyorova A, Kazakova A, Baryshev P, Shelihova L, Kalinina I, et al. Molecular characteristic of acute leukemias with t(16;21)/FUS-ERG. Ann Hematol. 2018;97:977-988 pubmed publisher
    T(16;21)(p11;q22)/FUS-ERG is a rare but recurrent translocation in acute leukemias and in some types of solid tumors. Due to multiple types of FUS-ERG transcripts, PCR-based minimal residual disease detection is impeded...
  40. Balasubramanian M, Sithambaram S, Smith K. Inherited duplication of the short arm of chromosome 18p11.32-p11.31 associated with developmental delay/intellectual disability. Clin Dysmorphol. 2016;25:19-22 pubmed publisher
    ..We report on a family where the father and his two daughters all have a duplication 18p11.32-p11.31 characterized by microarray...
  41. Pan Q, Hu P, Ou J, Jin X, Zhang F, Hu Y, et al. [Phenotypic and genetic analysis of a child featuring multiple malformations due to chromosome 18p deletion]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2015;32:695-9 pubmed publisher
    ..RESULTS The karyotype of the child was ascertained as 46,XX,del(18)(p11.2). Array CGH has identified a 9.8 Mb deletion at 18p11.32-p11.22...
  42. Bektas K, Belduz A, Guvenmez H, Sihay D. Fontibacillus pullulanilyticus sp.nov. isolated from soil. J Basic Microbiol. 2016;56:857-63 pubmed publisher
    ..8%) and Fontibacillus panacisegetis P11-6(T) (97.0%). The major fatty acid of strain DSHK107(T) was anteiso-C15:0 (46.7)...
  43. Nascimento G, Salay L, Sanches P, Cilli E. Molecular Interactions of an Ornithine-Rich pH-Responsive Self- Assembling Peptide with a Model Lipid Membrane: Conformational Aspects. Protein Pept Lett. 2016;23:790-4 pubmed
    ..Here the interaction of an ornithine-rich pH-responsive peptide called P11-5 with a model membrane was investigated employing Fourier transform infrared spectroscopy (FTIR)...
  44. Binette V, Côté S, Mousseau N. Free-Energy Landscape of the Amino-Terminal Fragment of Huntingtin in Aqueous Solution. Biophys J. 2016;110:1075-88 pubmed publisher
    ..of Q17P11 shifts the overall landscape to a more extended and helical Htt17 stabilized by interactions with Q17 and P11, which almost exclusively form a PPII-helix, as well as by intramolecular H-bonds and salt bridges...
  45. Abdelhedi F, El Khattabi L, Essid N, Viot G, Letessier D, Lebbar A, et al. A de novo 10p11.23-p12.1 deletion recapitulates the phenotype observed in WAC mutations and strengthens the role of WAC in intellectual disability and behavior disorders. Am J Med Genet A. 2016;170:1912-7 pubmed publisher
    ..WAC was suggested to be the main candidate gene for intellectual disability associated with 10 p11-p12 deletion syndrome. Here, we describe a new case of de novo 10p11.23-p12...
  46. Mermet Joret N, Chatila N, Pereira B, Monconduit L, Dallel R, Antri M. Lamina specific postnatal development of PKC? interneurons within the rat medullary dorsal horn. Dev Neurobiol. 2017;77:102-119 pubmed publisher
    ..In lamina III, they then decrease from P11-P15 to P60...
  47. Lan T, Chen H, Xiong B, Zhou T, Peng R, Chen M, et al. Primary pleuropulmonary and mediastinal synovial sarcoma: a clinicopathologic and molecular study of 26 genetically confirmed cases in the largest institution of southwest China. Diagn Pathol. 2016;11:62 pubmed publisher
    ..The chromosomal translocation t(X;18)(p11.2;q11...
  48. Miao Y, Lin P, Wang W, Jeffrey Medeiros L, Lu X. CCND1-IGH Fusion-Amplification and MYC Copy Number Gain in a Case of Pleomorphic Variant Mantle Cell Lymphoma. Am J Clin Pathol. 2016;146:747-752 pubmed publisher
    ..3;q21), del(2)(p21), del(6)(p23), add(7)(p22),-9, del(9)(p22), add(11)(q13),-13, add(14)(p11.2), der(14)t(11;14)(q13;q32)hsr(14)(q32), add(18)(q23), add(21)(p11.1),-22,+mar[12]...
  49. Menke J, Vasmatzis G, Murphy S, Yang L, Menke D, Tun H, et al. Mantle cell lymphoma with a novel t(11;12)(q13;p11.2): a proposed alternative mechanism of CCND1 up-regulation. Hum Pathol. 2017;64:207-212 pubmed publisher
    ..We identified a case of MCL showing cyclin D1 overexpression by immunohistochemistry and a t(11;12)(q13;p11.2) by conventional cytogenetic studies...
  50. Hoang L, Chiang S, Lee C. Endometrial stromal sarcomas and related neoplasms: new developments and diagnostic considerations. Pathology. 2018;50:162-177 pubmed publisher
    ..It also describes the recent characterisation of endometrial stromal sarcoma with t(X;22)(p11;q13) resulting in ZC3H7B-BCOR fusion, a noteworthy entity due to its close histological resemblance to myxoid ..
  51. Inokuchi K, Wakita S, Hirakawa T, Tamai H, Yokose N, Yamaguchi H, et al. RCSD1-ABL1-positive B lymphoblastic leukemia is sensitive to dexamethasone and tyrosine kinase inhibitors and rapidly evolves clonally by chromosomal translocations. Int J Hematol. 2011;94:255-260 pubmed publisher
    ..the subsequent development of three additional reciprocal chromosomal translocations, t(5;16)(q33;q24), dic(18;20)(p11.2;q11.2) and t(10;19)(q24;p13.3)...
  52. Deliyanti D, Wilkinson Berka J. Inhibition of NOX1/4 with GKT137831: a potential novel treatment to attenuate neuroglial cell inflammation in the retina. J Neuroinflammation. 2015;12:136 pubmed publisher
    ..in Sprague-Dawley rats by exposure to 80 % O2 cycled with 21 % O2 for 3 h per day from postnatal day (P) 0 to P11, followed by room air (P12 to P18)...
  53. Gopalakrishnapillai A, Kolb E, Dhanan P, Mason R, Napper A, Barwe S. Disruption of Annexin II /p11 Interaction Suppresses Leukemia Cell Binding, Homing and Engraftment, and Sensitizes the Leukemia Cells to Chemotherapy. PLoS ONE. 2015;10:e0140564 pubmed publisher
    ..Annexin II (ANX2) is abundantly expressed on bone marrow cells and complexes with p11 to form ANX2/p11-hetero-tetramer (ANX2T)...
  54. Zielińska M, Jarmuż A, Sałaga M, Kordek R, Laudon M, Storr M, et al. Melatonin, but not melatonin receptor agonists Neu-P11 and Neu-P67, attenuates TNBS-induced colitis in mice. Naunyn Schmiedebergs Arch Pharmacol. 2016;389:511-9 pubmed publisher
    ..effect of melatonin and to assess the anti-inflammatory potential of two novel MT receptor agonists, Neu-P11 and Neu-P67, in the mouse model of trinitrobenzenesulfonic acid (TNBS)-induced colitis...
  55. Vásquez Velásquez A, Rivera H, Castro A, Jaloma Cruz A, Juárez C, Lara Navarro I, et al. Two girls with a de novo Xq rearrangement of paternal origin: t(X;9)(q24;q12) or rea(X)dup q. Taiwan J Obstet Gynecol. 2016;55:275-80 pubmed publisher
    ..Patient 1 had a t(X;9)(q24;q12)dn. Patient 2 had a de novo rea(X)(qter?q23 or q24::p11.2?qter) concomitant with an unbalanced rob(14;21)mat...
  56. Veras F, Corrêa A, Welke J, Brandelli A. Inhibition of mycotoxin-producing fungi by Bacillus strains isolated from fish intestines. Int J Food Microbiol. 2016;238:23-32 pubmed publisher
    ..Bacillus sp. P1 and Bacillus sp. P11 had a remarkable antifungal effect on toxigenic fungi...
  57. Drommelschmidt K, Serdar M, Bendix I, Herz J, Bertling F, Prager S, et al. Mesenchymal stem cell-derived extracellular vesicles ameliorate inflammation-induced preterm brain injury. Brain Behav Immun. 2017;60:220-232 pubmed publisher
    ..Cellular degeneration and reactive gliosis at P5 and myelination at P11 were evaluated by immunohistochemistry and western blot...
  58. Malinverni A, Colovati M, Perez A, Caneloi T, Oliveira H, Kosyakova N, et al. Unusual Duplication in the Pericentromeric Region of Chromosome 9 in a Patient with Phenotypic Alterations. Cytogenet Genome Res. 2016;150:100-105 pubmed publisher
    ..specific for the pericentromeric region of chromosome 9 showed an unusual, rearranged chromosome 9, der(9)(pter?p11.2::q21.11?q12::p11.2?p13.2::q12?p11.2::q21.11?qter), that has not been described before...
  59. Trautmann M, Menzel J, Bertling C, Cyra M, Isfort I, Steinestel K, et al. FUS-DDIT3 Fusion Protein-Driven IGF-IR Signaling is a Therapeutic Target in Myxoid Liposarcoma. Clin Cancer Res. 2017;23:6227-6238 pubmed publisher
    ..Over 90% of myxoid liposarcoma are characterized by a reciprocal t(12;16)(q13;p11) translocation...
  60. Zhou J, Zhang J, Luo X, Li M, Yue Y, Laudon M, et al. Neu-P11, a novel MT1/MT2 agonist, reverses diabetes by suppressing the hypothalamic-pituitary-adrenal axis in rats. Eur J Pharmacol. 2017;812:225-233 pubmed publisher
    ..The objective of the present study was to investigate the effect of the MT1/MT2 melatonin agonist Neu-P11 on glucose and lipid metabolism in T2DM rats induced by a high fat diet combined with low doses of streptozotocin...
  61. Nakano A, Asano D, Kondo R, Mori A, Arima S, Ushikubo H, et al. Retinal neuronal cell loss prevents abnormal retinal vascular growth in a rat model of retinopathy of prematurity. Exp Eye Res. 2018;168:115-127 pubmed publisher
    ..Changes in retinal morphology, blood vessels, and proliferative status of vascular cells were evaluated on P11 and P14...
  62. Ren L, Dhaka A, Cao Y. Function and postnatal changes of dural afferent fibers expressing TRPM8 channels. Mol Pain. 2015;11:37 pubmed publisher
    ..The number of axonal branches on individual dural EGFP-positive fibers was decreased by 30% between P2 and P11. The density of dural EGFP-positive fibers was subsequently reduced by 50% between P16 and P21...
  63. Schintu N, Zhang X, Alvarsson A, Marongiu R, Kaplitt M, Greengard P, et al. p11 modulates L-DOPA therapeutic effects and dyskinesia via distinct cell types in experimental Parkinsonism. Proc Natl Acad Sci U S A. 2016;113:1429-34 pubmed publisher
    ..Subchronic L-DOPA increases levels of adaptor protein p11 (S100A10) in dopaminoceptive neurons of the striatum...
  64. Boda H, Uchida H, Takaiso N, Ouchi Y, Fujita N, Kuno A, et al. A PDE3A mutation in familial hypertension and brachydactyly syndrome. J Hum Genet. 2016;61:701-3 pubmed publisher
    ..Mutations in the PDE3A gene located at 12p12.2-p11.2 were recently identified in HTNB families. We found a novel heterozygous missense mutation c...
  65. Weiss R, Bitton A, Ben Shimon M, Elhaik Goldman S, Nahary L, Cooper I, et al. Annexin A2, autoimmunity, anxiety and depression. J Autoimmun. 2016;73:92-9 pubmed publisher
    ..their brains were examined for ANXA2 immunoglobulin G (IgG) and expression of ANXA2 and the closely linked protein p11. Very high levels of anti-ANXA2 antibodies (Abs) were associated with reduced anxiety in the open field 13...
  66. Abe A, Yamamoto Y, Katsumi A, Okamoto A, Tokuda M, Inaguma Y, et al. Rearrangement of VPS13B, a causative gene of Cohen syndrome, in a case of RUNX1-RUNX1T1 leukemia with t(8;12;21). Int J Hematol. 2018;108:208-212 pubmed publisher
    ..In the present study, we report genetic features of a variant three-way translocation of t(8;12;21)(q22;p11;q22) in a patient with AML...
  67. Wiland E, Yatsenko A, Kishore A, Stanczak H, Zdarta A, Ligaj M, et al. FISH and array CGH characterization of de novo derivative Y chromosome (Yq duplication and partial Yp deletion) in an azoospermic male. Reprod Biomed Online. 2015;31:217-24 pubmed publisher
    ..Standard cytogenetic G-banding was performed on metaphase spreads and a de-novo karyotype 46,X,der(Y)(q11.22;p11.3) was identified...
  68. Guo J, Zhang W, Zhang L, Ding H, Zhang J, Song C, et al. Probable involvement of p11 with interferon alpha induced depression. Sci Rep. 2016;6:17029 pubmed publisher
    ..shown that the serotonin receptors 5-HTR1b and 5-HTR4 play key roles in the anti-depression effects associated with p11 (S100A10)...
  69. Green H, Zhang X, Tiklová K, Volakakis N, Brodin L, Berg L, et al. Alterations of p11 in brain tissue and peripheral blood leukocytes in Parkinson's disease. Proc Natl Acad Sci U S A. 2017;114:2735-2740 pubmed publisher
    Individuals with Parkinson's disease (PD) often suffer from comorbid depression. P11 (S100A10), a member of the S100 family of proteins, is expressed widely throughout the body and is involved in major depressive disorder and ..
  70. Lim J, Song M, Cho Y, Kim W, Han S, Ryu J. Comparative analysis of microRNA and mRNA expression profiles in cells and exosomes under toluene exposure. Toxicol In Vitro. 2017;41:92-101 pubmed publisher
    ..we found that the eight putative target genes of the differentially expressed miRNAs under toluene exposure (EXOSC6, RHOH, GFER, HERC2, GOLGA4, SLC7A11, GCLM, and BACH1) are related to diverse disease categories such as nervous ..
  71. Minicka J, Elena S, Borodynko Filas N, Rubis B, Hasiów Jaroszewska B. Strain-dependent mutational effects for Pepino mosaic virus in a natural host. BMC Evol Biol. 2017;17:67 pubmed publisher
    ..this latter possibility, a subset of mutations were also introduced in a mild isolate of the European strain (PepMV-P11) and the fitness of the resulting clones measured...
  72. Kristensson F, Andersson Assarsson J, Kanerva N, Peltonen M, Carlsson B, Carlsson L. Long-term effects of bariatric surgery in patients with obesity and chromosome 16 p11.2 microdeletion. Surg Obes Relat Dis. 2017;13:1321-1325 pubmed publisher
    Chromosome 16 p11.2 microdeletion is associated with early-onset obesity. Information is limited about the effect of bariatric surgery in patients with genetic obesity...
  73. Ghasemy S, García Pindado J, Aboutalebi F, Dormiani K, Teixido M, Malakoutikhah M. Fine-tuning the physicochemical properties of peptide-based blood-brain barrier shuttles. Bioorg Med Chem. 2018;26:2099-2106 pubmed publisher
    ..However, for the peptides consecutively N-methylated from the N-terminus to the C-terminus (p1, p5, p11, p12 and p16), lipophilicity correlated well with the number of N-methylated amide bonds and the permeability of ..
  74. López Rodríguez J, Martínez Carmona F, Rodríguez Crespo I, Lizarbe M, Turnay J. Molecular dissection of the membrane aggregation mechanisms induced by monomeric annexin A2. Biochim Biophys Acta Mol Cell Res. 2018;1865:863-873 pubmed publisher
    ..In its heterotetrameric form, especially with protein S100A10 (p11), annexin A2 has been involved as a determinant factor in innumerable biological processes like tumor development ..
  75. Yang W, Mei F, Cheng X. EPAC1 regulates endothelial annexin A2 cell surface translocation and plasminogen activation. FASEB J. 2018;32:2212-2222 pubmed publisher
    ..AnxA2 can exist as a monomer or a heterotetrameric complex with S100A10 (P11) and plays a critical role in many cellular processes, including exocytosis, endocytosis, and membrane organization...
  76. Poterico J, Vásquez F, Chávez Pastor M, Trubnykova M, Chavesta F, Chirinos J, et al. A Peruvian Child with 18p-/18q+ Syndrome and Persistent Microscopic Hematuria. J Pediatr Genet. 2017;6:258-266 pubmed publisher
    ..Karyotype analysis of family members determined the mother as the carrier of a pericentric inversion: 18[inv(18)(p11.2q21.3)]...
  77. Esakky P, Hansen D, Drury A, Felder P, Cusumano A, Moley K. Testicular cells exhibit similar molecular responses to cigarette smoke condensate ex vivo and in vivo. FASEB J. 2018;32:63-72 pubmed publisher
    ..We explanted testis tissue at postnatal day (P)5.5 and cultured it until P11.5...
  78. Falk S, Bonneau F, Ebert J, Kögel A, Conti E. Mpp6 Incorporation in the Nuclear Exosome Contributes to RNA Channeling through the Mtr4 Helicase. Cell Rep. 2017;20:2279-2286 pubmed publisher
  79. Mukerji B, Balshan E, Haderer R, Shertz W, Graebe R. Adolescent Female With Turner's Syndrome and 46,X,der(Y) del(Y)(p11.2)del(q11.2) Karyotype With Gonadoblastoma and Dysgerminoma. Pediatr Dev Pathol. 2017;:1093526617690291 pubmed publisher
    ..without any functional Y genes in all the cells, unlike a mosaic pattern, represented as 46,X,der(Y)del(Y)(p11.2)del(q11.2)...
  80. Gladwin M, Yao X, Cowan M, Huang X, Schneider R, Grant L, et al. Retinoic acid reduces p11 protein levels in bronchial epithelial cells by a posttranslational mechanism. Am J Physiol Lung Cell Mol Physiol. 2000;279:L1103-9 pubmed
    b>p11 is a member of the S100 family of proteins, is the cellular ligand of annexin II, and interacts with the carboxyl region of 85-kDa cytosolic phospholipase A(2) (cPLA(2)), inhibiting cPLA(2) activity and arachidonic acid (AA) release...
  81. Basu U, Meng F, Keim C, Grinstein V, Pefanis E, Eccleston J, et al. The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates. Cell. 2011;144:353-63 pubmed publisher
    ..Our findings reveal a role for noncoding RNA surveillance machinery in generating antibody diversity. ..
  82. Mosinska P, Socała K, Nieoczym D, Laudon M, Storr M, Fichna J, et al. Anticonvulsant activity of melatonin, but not melatonin receptor agonists Neu-P11 and Neu-P67, in mice. Behav Brain Res. 2016;307:199-207 pubmed publisher
    ..Therefore, the purpose of the present study was to compare the anticonvulsant properties of novel MT agonists Neu-P11 and Neu-P67 with MLT in mice...
  83. Wang H, Xiao B, Ji X, Zhang J, Cao Y, Ni L, et al. [Phenotypic and genetic analysis of four patients with 13q33-q34 microdeletion]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2017;34:509-513 pubmed publisher
    ..Patient 2 showed 46, XX, der (13). Patient 3 showed 46, XX, r(13) (p11.2q32) [43]/45, XX, 13[4]/46, XX, r(13;13) [2]/47, XX, 2r(13;13) [1]...
  84. Chen C, Gherzi R, Ong S, Chan E, Raijmakers R, Pruijn G, et al. AU binding proteins recruit the exosome to degrade ARE-containing mRNAs. Cell. 2001;107:451-64 pubmed
    ..ARE recognition requires certain ARE binding proteins that can interact with the exosome and recruit it to unstable RNAs, thereby promoting their rapid degradation. ..
  85. Seth D, Hogg P, Gorrell M, McCaughan G, Haber P. Direct effects of alcohol on hepatic fibrinolytic balance: implications for alcoholic liver disease. J Hepatol. 2008;48:614-27 pubmed publisher
    ..We have recently identified increased expression of a number of genes (annexin A2 (ANXA2), p11, tPA and PAI-1) that implicate fibrinolysis in ALD progression...
  86. Kennedy B, Tran P, Kohli M, Maertens J, Gewirtz J, Georgieff M. Beneficial effects of postnatal choline supplementation on long-Term neurocognitive deficit resulting from fetal-Neonatal iron deficiency. Behav Brain Res. 2018;336:40-43 pubmed publisher
    ..Choline (5ppm) was given to half the nursing dams and weanlings in each group from P11-P30. P65 rat cognitive performance was assessed by novel object recognition (NOR)...
  87. Raijmakers R, Noordman Y, van Venrooij W, Pruijn G. Protein-protein interactions of hCsl4p with other human exosome subunits. J Mol Biol. 2002;315:809-18 pubmed
    ..These results indicate that the association of hCsl4p with the exosome is mediated by protein-protein interactions with hRrp42p and hRrp46p. ..
  88. Lai W, Chuang Y, Lin A. The effects and the toxicity increases caused by bicarbonate, chloride, and other water components during the UV/TiO2 degradation of oxazaphosphorine drugs. Environ Sci Pollut Res Int. 2017;24:14595-14604 pubmed publisher
    ..resulted in a lower degradation rate and less byproduct formation for IFO and CP, two newly identified byproducts, P11 (M.W. = 197) and P12 (M.W...
  89. Wang Y, Han S, Han R, Su Y, Li J. Propofol-induced downregulation of NR2B membrane translocation in hippocampus and spatial memory deficits of neonatal mice. Brain Behav. 2017;7:e00734 pubmed publisher
    ..p.) injected propofol (100 mg/kg body weight) once a day from postnatal day 6 (P6) to P11, group D1 administrated propofol (100 mg/kg, i.p.) at P6 solely and administrated normal saline (10 ml/kg, i.p...
  90. Stryker C, Camperchioli D, Mayer C, Alilain W, MARTIN R, MacFarlane P. Respiratory dysfunction following neonatal sustained hypoxia exposure during a critical window of brainstem extracellular matrix formation. Am J Physiol Regul Integr Comp Physiol. 2017;:ajpregu.00199.2017 pubmed publisher
    ..SH exposure between this period (P11-15) attenuated the HVR (assessed at P16) and increased aggrecan (but not WFA) expression in the nTS, DMNV and AP...
  91. van Hoof A, Parker R. Messenger RNA degradation: beginning at the end. Curr Biol. 2002;12:R285-7 pubmed
    ..Recent work indicates that 'ARE' instability elements recruit the exosome to promote rapid 3'-to-5' degradation of the mRNA. ..
  92. Gao X, Oshima K, Ueda T, Nakashima T, Kimura M. A three-dimensional model of RNase P in the hyperthermophilic archaeon Pyrococcus horikoshii OT3. Biochem Biophys Res Commun. 2017;493:1063-1068 pubmed publisher
    ..ions, while a heterodimer of PhoRpp21 and PhoRpp29 locates on a single-stranded loop connecting helices P11 and P12 in the specificity domain (S-domain) in PhopRNA, probably forming an appropriate conformation of the ..