Gene Symbol: EXOSC3
Description: exosome component 3
Alias: CGI-102, PCH1B, RRP40, Rrp40p, bA3J10.7, hRrp-40, p10, exosome complex component RRP40, exosome complex exonuclease RRP40, ribosomal RNA-processing protein 40
Species: human
Products:     EXOSC3

Top Publications

  1. Mukherjee D, Gao M, O Connor J, Raijmakers R, Pruijn G, Lutz C, et al. The mammalian exosome mediates the efficient degradation of mRNAs that contain AU-rich elements. EMBO J. 2002;21:165-74 pubmed
    ..Finally, PM-Scl75 protein was found to interact specifically with AREs. These data suggest that the interaction between the exosome and AREs plays a key role in regulating the efficiency of ARE-containing mRNA turnover. ..
  2. Raijmakers R, Egberts W, van Venrooij W, Pruijn G. Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring. J Mol Biol. 2002;323:653-63 pubmed
  3. Biancheri R, Cassandrini D, Pinto F, Trovato R, Di Rocco M, Mirabelli Badenier M, et al. EXOSC3 mutations in isolated cerebellar hypoplasia and spinal anterior horn involvement. J Neurol. 2013;260:1866-70 pubmed publisher
    ..b>EXOSC3 has been recently defined as a major cause of PCH type 1...
  4. Zanni G, Scotton C, Passarelli C, Fang M, Barresi S, Dallapiccola B, et al. Exome sequencing in a family with intellectual disability, early onset spasticity, and cerebellar atrophy detects a novel mutation in EXOSC3. Neurogenetics. 2013;14:247-50 pubmed publisher
    ..atrophy transmitted as an autosomal recessive trait identified the following two missense mutations in the EXOSC3 gene: a novel p.V80F mutation and a known p...
  5. Allmang C, Petfalski E, Podtelejnikov A, Mann M, Tollervey D, Mitchell P. The yeast exosome and human PM-Scl are related complexes of 3' --> 5' exonucleases. Genes Dev. 1999;13:2148-58 pubmed
  6. Raijmakers R, Noordman Y, van Venrooij W, Pruijn G. Protein-protein interactions of hCsl4p with other human exosome subunits. J Mol Biol. 2002;315:809-18 pubmed
    ..These results indicate that the association of hCsl4p with the exosome is mediated by protein-protein interactions with hRrp42p and hRrp46p. ..
  7. Chen C, Gherzi R, Ong S, Chan E, Raijmakers R, Pruijn G, et al. AU binding proteins recruit the exosome to degrade ARE-containing mRNAs. Cell. 2001;107:451-64 pubmed
    ..ARE recognition requires certain ARE binding proteins that can interact with the exosome and recruit it to unstable RNAs, thereby promoting their rapid degradation. ..
  8. Brouwer R, Vree Egberts W, Hengstman G, Raijmakers R, van Engelen B, Seelig H, et al. Autoantibodies directed to novel components of the PM/Scl complex, the human exosome. Arthritis Res. 2002;4:134-8 pubmed
    ..These results further support the conception that the autoimmune response may initially be directed to PM/Scl-100, whereas intermolecular epitope spreading may have caused the autoantibody response directed to the associated components. ..
  9. Schwabova J, Brožková D, Petrak B, Mojzisova M, Pavlíčková K, Haberlova J, et al. Homozygous EXOSC3 mutation c.92G?C, p.G31A is a founder mutation causing severe pontocerebellar hypoplasia type 1 among the Czech Roma. J Neurogenet. 2013;27:163-9 pubmed publisher
    ..Recently, causative mutations in EXOSC3 were reported in a majority of PCH1 patients, but the detailed clinical phenotype caused by EXOSC3 mutations, ..

More Information

Publications134 found, 100 shown here

  1. Brouwer R, Allmang C, Raijmakers R, van Aarssen Y, Egberts W, Petfalski E, et al. Three novel components of the human exosome. J Biol Chem. 2001;276:6177-84 pubmed
    ..Here we report the cloning of full-length cDNAs, which encode putative human homologues of the Rrp40p, Rrp41p, and Rrp46p components of the exosome...
  2. Khuzakhmetova V, Yakovleva O, Dmitrieva S, Khaertdinov N, Ziyatdinova G, Giniatullin R, et al. Prenatal hyperhomocysteinemia induces oxidative stress and accelerates 'aging' of mammalian neuromuscular synapses. Int J Dev Neurosci. 2019;75:1-12 pubmed publisher
    ..the main findings indicate that the intensity and the timing of transmitter release in synapses of neonatal (P6 and P10) hHCY rats acquired features of matured synaptic transmission of adult rats...
  3. Chen X, Nakada S, Donahue J, Chen R, Tucker R, Qiu J, et al. Neuroprotective effects of inter-alpha inhibitor proteins after hypoxic-ischemic brain injury in neonatal rats. Exp Neurol. 2019;317:244-259 pubmed publisher
    ..Brains were perfused, weighed and fixed 72 h after HI at P10. In a second, delayed treatment group, the same procedure was followed except that IAIPs or placebo were given at 6,..
  4. Chen X, Rivard L, Naqvi S, Nakada S, Padbury J, Sanchez Esteban J, et al. Expression and localization of Inter-alpha Inhibitors in rodent brain. Neuroscience. 2016;324:69-81 pubmed publisher
    ..IAIP proteins were detected by immunohistochemistry in cultured cells as well as brain sections from E18 mice and P10 rats...
  5. Kim S, Lee S. NLRP3 inflammasome activation in D-galactosamine and lipopolysaccharide-induced acute liver failure: role of heme oxygenase-1. Free Radic Biol Med. 2013;65:997-1004 pubmed publisher
    ..After GalN/LPS treatment, the hepatic expression of NLRP3, ASC, and caspase-1 (p10) was increased. In immunoprecipitation studies, hemin attenuated the interaction of NLRP3 with ASC and caspase-1...
  6. Goffigan Holmes J, Sanabria D, Diaz J, Flock D, Chavez Valdez R. Calbindin-1 Expression in the Hippocampus following Neonatal Hypoxia-Ischemia and Therapeutic Hypothermia and Deficits in Spatial Memory. Dev Neurosci. 2019;:1-15 pubmed publisher
    ..We induced cerebral HI in C57BL6 mice at postnatal day 10 (P10) with right carotid ligation and 45 min of hypoxia (FiO2 = 0...
  7. Wu M, Han W, Song S, Du Y, Liu C, Chen N, et al. NLRP3 deficiency ameliorates renal inflammation and fibrosis in diabetic mice. Mol Cell Endocrinol. 2018;478:115-125 pubmed publisher
    ..Renal expression of NLRP3, caspase-1 p10, interleukin-18 (IL-18) and cleaved IL-1β was increased in diabetic wild-type (WT) mice at 24 weeks...
  8. Graham A, Kiss D, Andrulis E. Core exosome-independent roles for Rrp6 in cell cycle progression. Mol Biol Cell. 2009;20:2242-53 pubmed publisher
    ..culture cells, dRrp6 is required for cell proliferation and error-free mitosis, but the core exosome subunit Rrp40 is not...
  9. Jiang T, Liu F, Wang W, Jiang X, Wen X, Hu K, et al. Distribution of Cathepsin K in Late Stage of Tooth Germ Development and Its Function in Degrading Enamel Matrix Proteins in Mouse. PLoS ONE. 2017;12:e0169857 pubmed publisher
    ..In this study, BALB/c mice at embryonic day 18 (E18), post-natal day 1 (P1), P5, P10 and P20 were used (5 mice at each time point)for systematic analyses of CTSK expression in the late stage of tooth ..
  10. Martino N, Rizzo A, Pizzi F, Dell Aquila M, Sciorsci R. Effects of kisspeptin-10 on in vitro proliferation and kisspeptin receptor expression in primary epithelial cell cultures isolated from bovine placental cotyledons of fetuses at the first trimester of pregnancy. Theriogenology. 2015;83:978-987.e1 pubmed publisher
    ..Cell population doubling time was evaluated for each culture passage (P) from P1 to P10. Cells were tested for Kiss-1R mRNA expression analysis by real-time reverse transcription-polymerase chain ..
  11. Schioppo T, Ingegnoli F. Current perspective on rituximab in rheumatic diseases. Drug Des Devel Ther. 2017;11:2891-2904 pubmed publisher
    ..Thus, the advent in clinical practice of approved RTX biosimilars, such as CT-P10, may be of help in improving treatment access as well as in reducing costs.
  12. Charles M, Drunalini Perera P, Doycheva D, Tang J. Granulocyte-colony stimulating factor activates JAK2/PI3K/PDE3B pathway to inhibit corticosterone synthesis in a neonatal hypoxic-ischemic brain injury rat model. Exp Neurol. 2015;272:152-9 pubmed publisher
    ..Sprague-Dawley rat pups at the age of 10days (P10) were subjected to unilateral carotid artery ligation followed by hypoxia for 2.5hours...
  13. Zhang D, Wang H, Yao C. Molecular and acute temperature stress response characterizations of caspase-8 gene in two mussels, Mytilus coruscus and Mytilus galloprovincialis. Comp Biochem Physiol B Biochem Mol Biol. 2014;177-178:10-20 pubmed publisher
    ..contained two highly conservative death effector domains (DEDs) at N-terminal, the caspase family domains P20 and P10 and the caspase family cysteine active site 'KPKLFFIQACQG'...
  14. Thanei S, Theron M, Silva A, Reis B, Branco L, Schirmbeck L, et al. Cathepsin S inhibition suppresses autoimmune-triggered inflammatory responses in macrophages. Biochem Pharmacol. 2017;146:151-164 pubmed publisher
    ..During the assembly of MHC class II-Ag peptide complexes, CatS cleaves the invariant chain p10 (Lip10) - a fragment of the MHC class II-associated invariant chain peptide...
  15. Sanchez Borges M, Capriles Hulett A, Torres J, Ansotegui Zubeldia I, Castillo A, Dhersy A, et al. [Diagnosis of allergic sensitization in patients with allergic rhinitis and asthma in a tropical environment]. Rev Alerg Mex. 2019;66:44-54 pubmed publisher
    ..4 %contained rBla g4, 19.9 % contained rFel d1, 11.8 % contained rArt v3, 11.2 % contained Der p10, 9.9 % contained rBla g2, 9.3 % contained rPer a7, 9.3 % contained nFel d2, and 8.7 % contained rCan f1...
  16. Burns D, Donkervoort S, Muller J, Knierim E, Bharucha Goebel D, Faqeih E, et al. Variants in EXOSC9 Disrupt the RNA Exosome and Result in Cerebellar Atrophy with Spinal Motor Neuronopathy. Am J Hum Genet. 2018;102:858-873 pubmed publisher
    ..Recessive variants in exosome components EXOSC3, EXOSC8, and RBM7 cause various constellations of pontocerebellar hypoplasia (PCH), spinal muscular atrophy (SMA), ..
  17. Yang J, Ju L, Yang C, Xue J, Setlow B, Morey T, et al. Effects of combined brief etomidate anesthesia and postnatal stress on amygdala expression of Cl- cotransporters and corticotropin-releasing hormone and alcohol intake in adult rats. Neurosci Lett. 2018;685:83-89 pubmed publisher
    ..subjected to 2 h of ET anesthesia on postnatal days (P) 4, 5, or 6 followed by maternal separation for 3 h on P10 (ET + SEP). During the P91-P120 period rats had daily 2 h access to three 0...
  18. Cho E, Kang H, Kang D, Lee Y. Myocardial-specific ablation of Jumonji and AT-rich interaction domain-containing 2 (Jarid2) leads to dilated cardiomyopathy in mice. J Biol Chem. 2019;294:4981-4996 pubmed publisher
    ..Pathway analyses revealed that dysregulated genes in Jarid2 αMHC hearts at p10, prior to cardiomyopathy, represented heart development and muscle contraction pathways...
  19. Mendelsberg Fishbein P, García Delgado C, Muñoz Martínez L, Robledo Cayetano M, Mejía Marín L, Martínez Barrera L, et al. [Pallister-Killian syndrome in a Mexican mestizo patient. Case report]. Arch Argent Pediatr. 2018;116:e135-e138 pubmed publisher
    ..The GTG banding karyotype analysis was normal, the skin fibroblast was mos47,XX,i(12)(p10)[85]/46,XX[21]...
  20. Yuan J, Zhu M, Deng S, Fan S, Xu H, Liao J, et al. Classical swine fever virus induces pyroptosis in the peripheral lymphoid organs of infected pigs. Virus Res. 2018;250:37-42 pubmed publisher
    ..Meanwhile, the p10 subunit and activity of caspase-1, which is a regulator of pyroptosis, the N-terminal domain of gasdermin D, which ..
  21. Walczyk D, Willkomm D, Hartmann R. Bacterial type B RNase P: functional characterization of the L5.1-L15.1 tertiary contact and antisense inhibition. RNA. 2016;22:1699-1709 pubmed
    ..of magnitude in vitro, largely retarded gel mobility of the RNA and further affected the structure of regions P7/P8/P10.1, P15 and L15.2, and abolished the ability of B...
  22. Zhu W, Cao F, Feng J, Chen H, Wan J, Lu Q, et al. NLRP3 inflammasome activation contributes to long-term behavioral alterations in mice injected with lipopolysaccharide. Neuroscience. 2017;343:77-84 pubmed publisher
    ..We also assessed protein expression of NLRP3, apoptosis-associated speck-like protein (ASC), and caspase-1 p10 in hippocampus by Western blotting; measured levels of interleukin (IL)-1?, IL-18, tumor necrosis factor ? (TNF?), ..
  23. Ju L, Yang J, Gravenstein N, Seubert C, Morey T, Sumners C, et al. Role of environmental stressors in determining the developmental outcome of neonatal anesthesia. Psychoneuroendocrinology. 2017;81:96-104 pubmed publisher
    ..To simulate stress after anesthesia, the animals were exposed to a single maternal separation for 3h at P10. 3-7days after exposure to etomidate the rats had increased hypothalamic NKCC1 mRNA and corticotropin releasing ..
  24. Al Mamun A, Yu H, Mirza M, Romana S, McCullough L, Liu F. Myeloid cell IRF4 signaling protects neonatal brains from hypoxic ischemic encephalopathy. Neurochem Int. 2018;: pubmed publisher
    ..IRF4 myeloid cell conditional knockout (CKO) postnatal day 10 (P10) male pups were subjected to a 60-min hypoxic-ischemic insult by the Rice-Vanucci model (RVM)...
  25. Muroi M, Tanamoto K. Zinc- and oxidative property-dependent degradation of pro-caspase-1 and NLRP3 by ziram in mouse macrophages. Toxicol Lett. 2015;235:199-205 pubmed publisher
    ..Ziram did not affect levels of pro-caspase-1 and NLRP3 mRNA, and no cleavage products of pro-caspase-1 including p10 subunit, which is an autocleavage product of pro-caspase-1, were detected, indicating that the decrease was ..
  26. An Z, Su J. Acinetobacter baumannii outer membrane protein 34 elicits NLRP3 inflammasome activation via mitochondria-derived reactive oxygen species in RAW264.7 macrophages. Microbes Infect. 2018;: pubmed publisher
    ..Omp34 induced the expression of caspase-1-p10 and IL-1β, which was significantly attenuated by NLRP3 gene silencing in RAW264.7 mouse macrophage cells...
  27. Nguyen S, Kwasny S, Ding X, Williams J, Peet N, Bowlin T, et al. Synthesis and antifungal evaluation of head-to-head and head-to-tail bisamidine compounds. Bioorg Med Chem. 2015;23:5789-98 pubmed publisher
    ..The most potent compounds, for example, P10, P19 and P34, are comparable in antifungal activities to amphotericin B (MIC 0.125 μg/ml)...
  28. Wu Y, Cui L, Zhu E, Zhou W, Wang Q, Wu X, et al. Muscovy duck reovirus ?NS protein triggers autophagy enhancing virus replication. Virol J. 2017;14:53 pubmed publisher
    ..Additionally, to determine which viral protein is responsible for MDRV-induced autophagy, both p10.8- and ?NS-encoding genes of MDRV were cloned into the pCI-neo-flag vector and transfected into DF-1 cells for ..
  29. Kim B, Serebreni L, Fallica J, Hamdan O, Wang L, Johnston L, et al. Cyclin-dependent kinase five mediates activation of lung xanthine oxidoreductase in response to hypoxia. PLoS ONE. 2015;10:e0124189 pubmed publisher
    ..cyclin-dependent kinase 5 activator 1 (CDK5r1 or p35/p25), and decreased expression of the CDK5 inhibitory peptide, p10. Expression of p35/p25 was necessary for XOR hyperactivation...
  30. Sánchez Tamayo T, Espinosa Fernandez M, Affumicato L, González López M, Fernández Romero V, Moreno Algarra M, et al. [Reduction in necrotising enterocolitis after implementing an evidence-based enteral nutrition protocol in very low birth weight newborns]. An Pediatr (Barc). 2016;85:291-299 pubmed publisher
    ..mortality and mortality due to NEC, nosocomial sepsis; weight at 28 days and 36 weeks; % of infants with weight <p10 at discharge; and length of stay...
  31. Dutta A, De R, Dolai T, Mitra P, Halder A. Cytogenetic study is not essential in patients with aplastic anemia. Am J Blood Res. 2017;7:49-58 pubmed
    ..96%) showed a unique chromosomal abnormality, i.e. 45,XY,rob(14:21)(p10:q10)[20]. In the second phase of study, among 19 BM & PVB paired samples, 1 (5.26%) showed abnormal karyotype i...
  32. Jeong T, Lee W, Yun Y, Chun S, Song J, Min W. Development and validation of the Korean version of CKD-EPI equation to estimate glomerular filtration rate. Clin Biochem. 2016;49:713-719 pubmed publisher
    ..The performance of the equation was evaluated by calculating the bias (estimated GFR-measured GFR). The ±10% (P10) and ±30% (P30) accuracies and root mean square errors (RMSEs) of the original and Korean CKD-EPI equations were ..
  33. Ran L, Ding Y, Luo L, Gan X, Li X, Chen Y, et al. Interaction research on an antiviral molecule that targets the coat protein of southern rice black-streaked dwarf virus. Int J Biol Macromol. 2017;103:919-930 pubmed publisher
    Southern rice black-streaked dwarf virus (SRBSDV) coat protein (P10) is the key protein required for viral transmission and host plant infection and is thus a promising target for anti-SRBSDV agent screening...
  34. Slhessarenko N, Fontes C, Slhessarenko M, Azevedo R, Andriolo A. Proposition of decision limits for serum lipids in Brazilian children aged one to 13 years. J Pediatr (Rio J). 2019;95:173-179 pubmed publisher
    ..LDL-cholesterol, non-HDL cholesterol, and triglycerides levels below the P75 percentile, and HDL-c above the P10 percentile...
  35. Raijmakers R, Egberts W, van Venrooij W, Pruijn G. The association of the human PM/Scl-75 autoantigen with the exosome is dependent on a newly identified N terminus. J Biol Chem. 2003;278:30698-704 pubmed
    ..This suggests that this basic element of PM/Scl-75 plays a role in targeting the exosome to the nucleolus. ..
  36. Lan K, Tien L, Cai Z, Lin S, Pang Y, Tanaka S, et al. Erythropoietin Ameliorates Neonatal Hypoxia-Ischemia-Induced Neurobehavioral Deficits, Neuroinflammation, and Hippocampal Injury in the Juvenile Rat. Int J Mol Sci. 2016;17:289 pubmed publisher
    ..erythropoietin (EPO) has been shown to be neuroprotective against hypoxia-ischemia (HI) in Postnatal Day 7 (P7)-P10 or adult animal models...
  37. Tøndel C, Bolann B, Salvador C, Brackman D, Bjerre A, Svarstad E, et al. Iohexol plasma clearance in children: validation of multiple formulas and two-point sampling times. Pediatr Nephrol. 2017;32:311-320 pubmed publisher
    ..correction of the distribution phase improved the performance of the original Brøchner-Mortensen method from 1972; P10 of 92.7 % compared to P10 of 82...
  38. Niese R, Tobalske B. Specialized primary feathers produce tonal sounds during flight in rock pigeons (Columba livia). J Exp Biol. 2016;219:2173-81 pubmed publisher
    ..tones are produced when a small region of long, curved barbs on the inner vane of the outermost primary feather (P10) aeroelastically flutters...
  39. Tinning A, Jensen B, Johnsen I, Chen D, Coffman T, Madsen K. Vascular endothelial growth factor signaling is necessary for expansion of medullary microvessels during postnatal kidney development. Am J Physiol Renal Physiol. 2016;311:F586-99 pubmed publisher
    ..Rat pups treated with the VEGF receptor-2 (VEGFR2) inhibitor vandetanib (100 mg·kg(-1)·day(-1)) from P7 to P12 or P10 to P16 displayed growth retardation and proteinuria...
  40. Rohampour K, Azizi H, Fathollahi Y, Semnanian S. Peripheral nerve injury potentiates excitatory synaptic transmission in locus coeruleus neurons. Brain Res Bull. 2017;130:112-117 pubmed publisher
    ..CCI was performed on P10 to P12 Sprague Dawley pups...
  41. Huizenga M, Wicker E, Beck V, Forcelli P. Anticonvulsant effect of cannabinoid receptor agonists in models of seizures in developing rats. Epilepsia. 2017;58:1593-1602 pubmed publisher
    ..Finally, after pretreatment with WIN, P10 Sprague-Dawley rats were challenged against acute hypoxia-induced seizures...
  42. Xiao R, Yu D, Li X, Huang J, Jing S, Bao X, et al. Propofol Exposure in Early Life Induced Developmental Impairments in the Mouse Cerebellum. Front Cell Neurosci. 2017;11:373 pubmed publisher
    ..and Bergmann glial cell development were evaluated on P8, and granule neuron migration was analyzed on P10. The results indicated that exposure to propofol on P7 resulted in a significant reduction in calbindin-labeled ..
  43. Dixon B, Malaguit J, Casel D, Doycheva D, Tang J, Zhang J, et al. Osteopontin-Rac1 on Blood-Brain Barrier Stability Following Rodent Neonatal Hypoxia-Ischemia. Acta Neurochir Suppl. 2016;121:263-7 pubmed publisher
    ..nHI was induced by unilateral ligation of the right carotid artery followed by hypoxia (8 % oxygen for 2 h) in P10 Sprague-Dawley rat pups. Intranasal (iN) OPN was administered at 1 h post-nHI...
  44. Sun S, Ge X, Zhu J, Zhang W, Zhang Q. Molecular cloning, immunohistochemical localization, characterization and expression analysis of caspase-8 from the blunt snout bream (Megalobrama amblycephala) exposed to ammonia. Fish Shellfish Immunol. 2015;47:645-54 pubmed publisher
    ..contained two highly conservative death effector domains (DEDs) at N-terminal, the caspase family domains P20 and P10, caspase-8 active-site pentapeptide and potential aspartic acid cleavage sites...
  45. Uwineza A, Hitayezu J, Jamar M, Caberg J, Murorunkwere S, Janvier N, et al. Cytogenetic Studies of Rwandan Pediatric Patients Presenting with Global Developmental Delay, Intellectual Disability and/or Multiple Congenital Anomalies. J Trop Pediatr. 2016;62:38-45 pubmed publisher
    ..identified chromosomal abnormalities included 47,XX,+del(9)(q11), 46,XY,del(13)(q34) and 46,XX,der(22)t(10;22)(p10;p10)mat...
  46. Wu H, He Z, Tang J, Li X, Cao H, Wang Y, et al. A critical role of LAMP-1 in avian reovirus P10 degradation associated with inhibition of apoptosis and virus release. Arch Virol. 2016;161:899-911 pubmed publisher
    ..The ARV p10 protein, a viroporin responsible for the induction of cell syncytium formation and apoptosis, is rapidly degraded ..
  47. Chaibva M, Jawahery S, Pilkington A, Arndt J, Sarver O, VALENTINE S, et al. Acetylation within the First 17 Residues of Huntingtin Exon 1 Alters Aggregation and Lipid Binding. Biophys J. 2016;111:349-362 pubmed publisher
    ..Acetylation of htt-exon1(51Q) and synthetic truncated htt-exon 1 mimicking peptides (Nt(17)-Q35-P10-KK) was achieved using a selective covalent label, sulfo-N-hydroxysuccinimide (NHSA)...
  48. Liu Y, Chen J, Zhang Z, Ma X, Chen Y, Du X, et al. NLRP3 inflammasome activation mediates radiation-induced pyroptosis in bone marrow-derived macrophages. Cell Death Dis. 2017;8:e2579 pubmed publisher
    ..Nlrp3 knock out significantly diminished the quantity of cleaved-Caspase-1 (p10) and IL-1β as well as the proportion of pyroptosis. Additionally, in vivo research shows that 9...
  49. Williams R, Aalseth C, Brandenberger J, Day A, Finn E, Fuller E, et al. Development of a low-level 39Ar calibration standard - Analysis by absolute gas counting measurements augmented with simulation. Appl Radiat Isot. 2017;126:243-248 pubmed publisher
    ..The total expanded uncertainty of the specific activity for the ~50× 39Ar in P10 standard is 3.6% (k=2).
  50. Moots R, Azevedo V, Coindreau J, Dorner T, Mahgoub E, Mysler E, et al. Switching Between Reference Biologics and Biosimilars for the Treatment of Rheumatology, Gastroenterology, and Dermatology Inflammatory Conditions: Considerations for the Clinician. Curr Rheumatol Rep. 2017;19:37 pubmed publisher
    ..Adalimumab publications covered ABP 501 (2) and SB5 (1). Rituximab publications covered CT-P10 (1)...
  51. Díaz P, Rey F, Gareis N, Notaro U, Matiller V, Belotti E, et al. Altered Expression of Anti-Müllerian Hormone during the Early Stage of Bovine Persistent Ovarian Follicles. J Comp Pathol. 2018;158:22-31 pubmed publisher
    ..5, 10 and 15 days after the expected day of ovulation (day 0 of follicular persistence) in treated cows (groups P5, P10 and P15, respectively), using an intravaginal progesterone-releasing device...
  52. Joksovic P, Lunardi N, Jevtovic Todorovic V, Todorovic S. Early Exposure to General Anesthesia with Isoflurane Downregulates Inhibitory Synaptic Neurotransmission in the Rat Thalamus. Mol Neurobiol. 2015;52:952-8 pubmed publisher
    ..eIPSCs) from intact neurons of the nucleus reticularis thalami (nRT) in brain slices from rat pups (postnatal age P10-P18) exposed at age of P7 to clinically relevant GA combinations of Iso and N2O...
  53. Corrêa A, Senna J, de Sousa Ã. Effects of passage number on growth and productivity of hybridoma secreting MRSA anti-PBP2a monoclonal antibodies. Cytotechnology. 2016;68:419-27 pubmed publisher
    ..antibody productivity, and metabolite characteristics revealed substantial differences in those cells kept between P10 and P50...
  54. Sajjan D, Hinchigeri S. Structural Organization of Baculovirus Occlusion Bodies and Protective Role of Multilayered Polyhedron Envelope Protein. Food Environ Virol. 2016;8:86-100 pubmed publisher
    ..OB is an organized structure, chiefly composed of proteins namely polyhedrin, polyhedron envelope protein (PEP) and P10. Currently, the structural organization of OB is poorly understood and the role of OB proteins in conferring the ..
  55. Tadros M, Fuglevand A, Brichta A, Callister R. Intrinsic excitability differs between murine hypoglossal and spinal motoneurons. J Neurophysiol. 2016;115:2672-80 pubmed publisher
    ..recording to compare the electrophysiological properties of HMs and SMs in age-matched neonatal mice (P7-P10)...
  56. Buske C, Ogura M, Kwon H, Yoon S. An introduction to biosimilar cancer therapeutics: definitions, rationale for development and regulatory requirements. Future Oncol. 2017;13:5-16 pubmed publisher
    ..The path to approval is discussed with reference to the rituximab biosimilar CT-P10, the first licensed monoclonal antibody biosimilar cancer therapeutic.
  57. Schwaller F, Kwok C, Fitzgerald M. Postnatal maturation of the spinal-bulbo-spinal loop: brainstem control of spinal nociception is independent of sensory input in neonatal rats. Pain. 2016;157:677-86 pubmed publisher
    ..of RVM neurons with microinjection of DL-homocysteic acid did not alter the net activity of dorsal horn neurons at P10, suggesting an absence of glutamatergic drive, whereas the same injections caused significant facilitation at P21...
  58. van de Laar A, de Brauw M, Bruin S, Acherman Y. Weight-Independent Percentile Chart of 2880 Gastric Bypass Patients: a New Look at Bariatric Weight Loss Results. Obes Surg. 2016;26:2891-2898 pubmed
    ..a new metric rendering outcome independent of baseline BMI, is used to build percentile curves p97/p90/p75/p50/p25/p10/p03 with the lambda-mu-sigma method...
  59. Desroziers E, Brock O, Bakker J. Potential contribution of progesterone receptors to the development of sexual behavior in male and female mice. Horm Behav. 2017;90:31-38 pubmed publisher
    ..of male and female C57Bl/6j mice were treated with ZK 137316 or OIL as control: males were treated neonatally (P0-P10), during the critical period for male sexual differentiation, and females were treated prepubertally (P15-P25), ..
  60. Heinonen J, Zhang F, Surmann Schmitt C, Honkala S, Stock M, Poutanen M, et al. Defects in chondrocyte maturation and secondary ossification in mouse knee joint epiphyses due to Snorc deficiency. Osteoarthritis Cartilage. 2017;25:1132-1142 pubmed publisher
    ..were enlarged with higher extracellular matrix (ECM) volume and rounded chondrocyte morphology at postnatal days P10 and P22. Increased levels of Ihh and Col10a1, and reduced Mmp13 mRNA expression were observed at P10...
  61. Holanda R, Muñoz J, Dias L, Silva L, Santos J, Pagliari S, et al. Recombinant vaccines of a CD4+ T-cell epitope promote efficient control of Paracoccidioides brasiliensis burden by restraining primary organ infection. PLoS Negl Trop Dis. 2017;11:e0005927 pubmed publisher
    ..We tested the hypothesis that the immunogenicity of the immunodominant CD4+ T-cell epitope (P10) of Paracoccidioides brasiliensis gp43 antigen might be significantly enhanced by using a hepatitis B virus-derived ..
  62. Colla E, Panattoni G, Ricci A, Rizzi C, Rota L, Carucci N, et al. Toxic properties of microsome-associated alpha-synuclein species in mouse primary neurons. Neurobiol Dis. 2018;111:36-47 pubmed publisher
    ..We found that by comparison with non-microsomal associated αS (P10), the ER/M-associated αS pool is a unique population of oligomers and aggregates with specific biochemical traits ..
  63. Rausch R, Libby R, Kiernan A. Trabecular meshwork morphogenesis: A comparative analysis of wildtype and anterior segment dysgenesis mouse models. Exp Eye Res. 2018;170:81-91 pubmed publisher
    ..We further discovered that both mutants exhibited similar patterns of developmental TM dysgenesis at P1, P5, and P10. Our data indicate that P1 is an important time point in TM development and that TM dysgenesis in Jag1 and Bmp4 ..
  64. Erazo A, Goff S. Nuclear matrix protein Matrin 3 is a regulator of ZAP-mediated retroviral restriction. Retrovirology. 2015;12:57 pubmed publisher
    ..of Matrin 3-associated proteins uncovered interactions with proteins of the ZAP degradation complex, DDX17 and EXOSC3. Coimmunoprecipitation studies confirmed Matrin 3 associations with DDX17, EXOSC3 and ZAP, in a largely RNA-..
  65. Zhang M, Ji M, Zhao Q, Jia M, Qiu L, Peng Y, et al. Neurobehavioural abnormalities induced by repeated exposure of neonatal rats to sevoflurane can be aggravated by social isolation and enrichment deprivation initiated after exposure to the anaesthetic. Br J Anaesth. 2015;115:752-60 pubmed publisher
    ..progenitor proliferation was evaluated at P11 and P53 after administration of bromodeoyuridine (BrdU) at P8 to P10 and at P22 to P27, respectively. Neurobehavioural evaluations were performed at P49 to P53...
  66. Lopes L, Patrone L, Li K, Imber A, Graham C, Gargaglioni L, et al. Anatomical and functional connections between the locus coeruleus and the nucleus tractus solitarius in neonatal rats. Neuroscience. 2016;324:446-68 pubmed publisher
    ..coeruleus (LC) or into the caudal part of the nucleus tractus solitarius (cNTS) in Sprague-Dawley rat pups (P7-P10)...
  67. Giunta M, Edvardson S, Xu Y, Schuelke M, Gómez Durán A, Boczonadi V, et al. Altered RNA metabolism due to a homozygous RBM7 mutation in a patient with spinal motor neuropathy. Hum Mol Genet. 2016;25:2985-2996 pubmed
    ..Mutations in its subunits EXOSC8 and EXOSC3 cause pontocerebellar hypoplasia, spinal muscular atrophy (SMA) and central nervous system demyelination...
  68. Hanke Gogokhia C, Wu Z, Sharif A, Yazigi H, Frederick J, Baehr W. The guanine nucleotide exchange factor Arf-like protein 13b is essential for assembly of the mouse photoreceptor transition zone and outer segment. J Biol Chem. 2017;292:21442-21456 pubmed publisher
    ..Ultrastructure of postnatal day 10 (P10) central retArl13b-/- photoreceptors revealed docking of basal bodies to cell ..
  69. Pottel H, Schaeffner E, Ebert N. Evaluating the diagnostic value of rescaled β-trace protein in combination with serum creatinine and serum cystatin C in older adults. Clin Chim Acta. 2018;480:206-213 pubmed publisher
    ..b>P10 = 57.8%, P30 = 96.6%) did not outperform the Scr/ScysC-combined FAS-eq...
  70. Sinclair A, Cao M, Baskin L, Cunha G. Diethylstilbestrol-induced mouse hypospadias: "window of susceptibility". Differentiation. 2016;91:1-18 pubmed publisher
    ..with 200 ng/gbw DES every other day from embryonic day 12-18 (DES E12-E18), postnatal day 0-10 (DES P0-P10), embryonic day 12 to postnatal day 10 (DES E12-P10), postnatal day 5-15 (DES P5-P15), and postnatal day 10-20 (DES ..
  71. Pearlstein E, Michel F, Save L, Ferrari D, Hammond C. Abnormal Development of Glutamatergic Synapses Afferent to Dopaminergic Neurons of the Pink1(-/-) Mouse Model of Parkinson's Disease. Front Cell Neurosci. 2016;10:168 pubmed publisher
    ..We used immature (postnatal days P2-P10) and young adult (P30-P90) midbrain slices of pink1(-/-) mice expressing the green fluorescent protein in tyrosine ..
  72. Yu G, Bai Z, Chen Z, Chen H, Wang G, Wang G, et al. The NLRP3 inflammasome is a potential target of ozone therapy aiming to ease chronic renal inflammation in chronic kidney disease. Int Immunopharmacol. 2017;43:203-209 pubmed publisher
    ..The expression of NLRP3, ASC, and caspase-1-p10 in the kidney of these rats was simultaneously lowered by ozone therapy...
  73. Obameso J, Li H, Jia H, Han M, Zhu S, Huang C, et al. The persistent prevalence and evolution of cross-family recombinant coronavirus GCCDC1 among a bat population: a two-year follow-up. Sci China Life Sci. 2017;60:1357-1363 pubmed publisher
    ..study reported the discovery of a bat-derived putative cross-family recombinant coronavirus with a reovirus gene p10, named as Ro-BatCoV GCCDC1...
  74. van de Laar A, van Rijswijk A, Kakar H, Bruin S. Sensitivity and Specificity of 50% Excess Weight Loss (50%EWL) and Twelve Other Bariatric Criteria for Weight Loss Success. Obes Surg. 2018;28:2297-2304 pubmed publisher
    ..6 (patients' expectation), p25 (interquartile range), p15.9 (1 standard deviation (SD) below median), and p10.9 (surgeons' goal) were used as possible cutoff for success to determine true or false positive and negative ..
  75. Morton D, Kuiper E, Jones S, Leung S, Corbett A, Fasken M. The RNA exosome and RNA exosome-linked disease. RNA. 2018;24:127-142 pubmed publisher
    ..Mutations in the RNA exosome genes EXOSC3 and EXOSC8 cause pontocerebellar hypoplasia type 1b (PCH1b) and type 1c (PCH1c), respectively, which ..
  76. Zhu Y, Chen G, Lv F, Wang X, Ji X, Xu Y, et al. Zinc-finger antiviral protein inhibits HIV-1 infection by selectively targeting multiply spliced viral mRNAs for degradation. Proc Natl Acad Sci U S A. 2011;108:15834-9 pubmed publisher
    ..Our results indicate that ZAP inhibits HIV-1 by recruiting both the 5' and 3' mRNA degradation machinery to specifically promote the degradation of multiply spliced HIV-1 mRNAs. ..
  77. Stefanon B, Colitti M. Original Research: Hydroxytyrosol, an ingredient of olive oil, reduces triglyceride accumulation and promotes lipolysis in human primary visceral adipocytes during differentiation. Exp Biol Med (Maywood). 2016;241:1796-802 pubmed publisher
    ..Pre-adipocytes were analyzed after 10 (P10) and 20 (P20) days of treatment during differentiation and after 7 (A7) days of treatment when they reached mature ..
  78. Kidder I, Mudery J, Barreda S, Taska D, Bailey E. Evaluating the control: minipump implantation and breathing behavior in the neonatal rat. J Appl Physiol (1985). 2016;121:615-22 pubmed publisher
    ..1, 48 Sprague-Dawley rat pups (Charles-River Laboratories), ages postnatal day 7 (P7) through postnatal day 10 (P10), were drawn from two experimental groups, saline-exposed (n = 24) and unexposed (n = 24), and studied on P7, P8, ..
  79. Zhao F, Qu Y, Zhu J, Zhang L, Huang L, Liu H, et al. miR-30d-5p Plays an Important Role in Autophagy and Apoptosis in Developing Rat Brains After Hypoxic-Ischemic Injury. J Neuropathol Exp Neurol. 2017;76:709-719 pubmed publisher
    ..Through a miRNA microarray analysis in a P10 rat model of cerebral HI, we found that miR-30d-5p was one of the most deregulated miRNAs in neonatal brains in ..
  80. Wang Y, Xu Y, Sheng H, Ni X, Lu J. Exercise amelioration of depression-like behavior in OVX mice is associated with suppression of NLRP3 inflammasome activation in hippocampus. Behav Brain Res. 2016;307:18-24 pubmed publisher
    ..The levels of NLRP3, cleaved caspase-1 P10 and CD11b in hippocampus were increased in OVX mice compared with control group...
  81. da Silva R, de Carvalho I, de Matos R, Yamasaki L, Bittar C, Rahal P, et al. Evidence of bottleneck effect on hepatitis C virus transmission between a couple under interferon based therapy. Infect Genet Evol. 2017;47:87-93 pubmed publisher
    ..This study included two patients (P10 and P11) HCV genotype 1b infected. The couple presented horizontal transmission...
  82. Nile S, Keum Y, Nile A, Kwon Y, Kim D. Potential cow milk xanthine oxidase inhibitory and antioxidant activity of selected phenolic acid derivatives. J Biochem Mol Toxicol. 2017;: pubmed publisher
    ..412), P2 (0.632), P3 (0.585), P4 (0.886), P5 (1.633), P6 (0.503), P7 (2.882), P8 (3.761), P9 (4.487), and P10 (5.841) ?M...
  83. Loing E, Andrieu M, Thiam K, Schörner D, Wiesmuller K, Hosmalin A, et al. Extension of HLA-A*0201-restricted minimal epitope by N epsilon-palmitoyl-lysine increases the life span of functional presentation to cytotoxic T cells. J Immunol. 2000;164:900-7 pubmed
    ..HLA-A*0201-restricted HIV-1 polymerase (pol476-484) minimal cytotoxic epitope were obtained by modifying P0, P1, or P10 positions by a single N epsilon-palmitoyl-lysine residue...
  84. Fasken M, Losh J, Leung S, Brutus S, Avin B, Vaught J, et al. Insight into the RNA Exosome Complex Through Modeling Pontocerebellar Hypoplasia Type 1b Disease Mutations in Yeast. Genetics. 2017;205:221-237 pubmed publisher
    ..PCH1b is caused by mutations in the RNA exosome subunit gene, EXOSC3 The RNA exosome is an evolutionarily conserved complex, consisting of nine different core subunits, and one or two ..
  85. Cheng M, Zhang Y, Li X, Liang J, Hu L, Gong P, et al. Endolysin LysEF-P10 shows potential as an alternative treatment strategy for multidrug-resistant Enterococcus faecalis infections. Sci Rep. 2017;7:10164 pubmed publisher
    ..In this study, the potential of LysEF-P10, a new lysin derived from a isolated Enterococcus faecalis phage EF-P10, as an alternative treatment for multidrug-..
  86. Van Opstal D, Van Maarle M, Lichtenbelt K, Weiss M, Schuring Blom H, Bhola S, et al. Origin and clinical relevance of chromosomal aberrations other than the common trisomies detected by genome-wide NIPS: results of the TRIDENT study. Genet Med. 2017;: pubmed publisher
    ..of the 22 (59%) placental aberrations were associated with fetal congenital anomalies and/or poor fetal growth (<p10), which was severe (<p2.3) in six cases...
  87. Mazzoni J, Smith J, Shahriar S, Cutforth T, Ceja B, Agalliu D. The Wnt Inhibitor Apcdd1 Coordinates Vascular Remodeling and Barrier Maturation of Retinal Blood Vessels. Neuron. 2017;96:1055-1069.e6 pubmed publisher
    ..Apcdd1-deficient mice exhibit a transient increase in vessel density at ages P10-P12 due to delayed vessel pruning...
  88. Guo X, Ma J, Sun J, Gao G. The zinc-finger antiviral protein recruits the RNA processing exosome to degrade the target mRNA. Proc Natl Acad Sci U S A. 2007;104:151-6 pubmed
    ..Depletion of the exosome component hRrp41p or hRrp46p with small interfering RNA significantly reduced ZAP's destabilizing activity. These findings suggest that ZAP is a trans-acting factor that modulates mRNA stability. ..
  89. Raza F, McGouran J, Kessler B, Possee R, King L. Phosphorylation Induces Structural Changes in the Autographa californica Nucleopolyhedrovirus P10 Protein. J Virol. 2017;91: pubmed publisher
    ..b>P10 is a 10-kDa auxiliary protein produced in the very late phase of gene transcription by Autographa californica ..
  90. Liu Q, Greimann J, Lima C. Reconstitution, activities, and structure of the eukaryotic RNA exosome. Cell. 2006;127:1223-37 pubmed
    ..To elucidate the architecture of a eukaryotic exosome, its conserved surfaces, and the structural basis for RNA decay, we report the X-ray structure determination for the 286 kDa nine-subunit human exosome at 3.35 A. ..
  91. Alves J, Garay Malpartida M, Occhiucci J, Belizário J. Modulation of procaspase-7 self-activation by PEST amino acid residues of the N-terminal prodomain and intersubunit linker. Biochem Cell Biol. 2017;95:634-643 pubmed publisher
    Procaspase-7 zymogen polypeptide is composed of a short prodomain, a large subunit (p20), and a small subunit (p10) connected to an intersubunit linker...
  92. Goren B, Cakir A, Ocalan B, Serter Kocoglu S, Alkan T, Cansev M, et al. Long-term cognitive effects of uridine treatment in a neonatal rat model of hypoxic-ischemic encephalopathy. Brain Res. 2017;1659:81-87 pubmed publisher
    ..Part of pups in each group were sacrificed on P10 to collect brain samples for active Caspase-3 analyses and the remaining pups were raised through P40 to evaluate ..