EXOSC1

Summary

Gene Symbol: EXOSC1
Description: exosome component 1
Alias: CGI-108, CSL4, Csl4p, SKI4, Ski4p, p13, exosome complex component CSL4, 3'-5' exoribonuclease CSL4 homolog, exosomal core protein CSL4, homolog of yeast exosomal core protein CSL4
Species: human
Products:     EXOSC1

Top Publications

  1. Brouwer R, Allmang C, Raijmakers R, van Aarssen Y, Egberts W, Petfalski E, et al. Three novel components of the human exosome. J Biol Chem. 2001;276:6177-84 pubmed
    ..hRrp41p was expressed in yeast and shown to suppress the lethality of genetic depletion of yeast Rrp41p. We conclude that hRrp40p, hRrp41p, and hRrp46p represent novel components of the human exosome complex. ..
  2. Tomecki R, Kristiansen M, Lykke Andersen S, Chlebowski A, Larsen K, Szczesny R, et al. The human core exosome interacts with differentially localized processive RNases: hDIS3 and hDIS3L. EMBO J. 2010;29:2342-57 pubmed publisher
    ..Both hDIS3 and hDIS3L are active exonucleases; however, only hDIS3 has retained endonucleolytic activity. Our data suggest that three different ribonucleases can serve as catalytic subunits for the exosome in human cells. ..
  3. Liu Q, Greimann J, Lima C. Reconstitution, activities, and structure of the eukaryotic RNA exosome. Cell. 2006;127:1223-37 pubmed
    ..To elucidate the architecture of a eukaryotic exosome, its conserved surfaces, and the structural basis for RNA decay, we report the X-ray structure determination for the 286 kDa nine-subunit human exosome at 3.35 A. ..
  4. Nijim Y, Awni Y, Adawi A, Bowirrat A. Classic Case Report of Donohue Syndrome (Leprechaunism; OMIM *246200): The Impact of Consanguineous Mating. Medicine (Baltimore). 2016;95:e2710 pubmed publisher
    ..3-p13.2)...
  5. Rahimzadeh S, Pirzad A. Arbuscular mycorrhizal fungi and Pseudomonas in reduce drought stress damage in flax (Linum usitatissimum L.): a field study. Mycorrhiza. 2017;27:537-552 pubmed publisher
    ..Funneliformis mosseae or Rhizophagus intraradices) and a phosphate solubilizing bacterium (Pseudomonas putida P13; PSB) was evaluated under different irrigation regimes (irrigation after 60, 120, and 180 mm of evaporation from ..
  6. Zhang Y, Wei Z, Li J, Liu P. Molecular pathogenesis of lymphomas of mucosa-associated lymphoid tissue--from (auto)antigen driven selection to the activation of NF-κB signaling. Sci China Life Sci. 2015;58:1246-55 pubmed publisher
    ..among them are important translocations, such as t(11;18)(q21;q21), t(1;14)(p22;q32), t(14;18)(q32;q21) and t(3;14)(p13;q32)...
  7. Erban T, Rybanska D, Harant K, Hortova B, Hubert J. Feces Derived Allergens of Tyrophagus putrescentiae Reared on Dried Dog Food and Evidence of the Strong Nutritional Interaction between the Mite and Bacillus cereus Producing Protease Bacillolysins and Exo-chitinases. Front Physiol. 2016;7:53 pubmed publisher
    ..The 2D-E-MS/MS proteomic analysis identified mite trypsin allergen Tyr p3, fatty acid-binding protein Tyr p13 and putative mite allergens ferritin (Grp 30) and (poly)ubiquitins...
  8. Brycki B, Małecka I, Kozirog A, Otlewska A. Synthesis, Structure and Antimicrobial Properties of Novel Benzalkonium Chloride Analogues with Pyridine Rings. Molecules. 2017;22: pubmed publisher
    ..Therefore new BAC analogues P13-P18 with pyridine rings were synthesized...
  9. Wang J, Lin J, Kaiser U, Wohlfart P, Hammes H. Absence of macrophage migration inhibitory factor reduces proliferative retinopathy in a mouse model. Acta Diabetol. 2017;54:383-392 pubmed publisher
    ..Gene expression of selected proangiogenic and proinflammatory factors at postnatal day 13 (p13) was measured by real-time PCR...

More Information

Publications139 found, 100 shown here

  1. Chen L, Chen C, Jiaang W, Chen T, Butterfield J, Shih N, et al. BPR1J373, an Oral Multiple Tyrosine Kinase Inhibitor, Targets c-KIT for the Treatment of c-KIT-Driven Myeloid Leukemia. Mol Cancer Ther. 2016;15:2323-2333 pubmed
    Acute myelogenous leukemia (AML) carrying t(8;21)(q22;q22) or inv(16)/t(16;16)(p13;q22) is classified as core binding factor (CBF)-AML and accounts for approximately 15% of AML...
  2. Li L, Li Y, Zhao D, Jin M, Ni H. Leptin-regulated autophagy plays a role in long-term neurobehavioral injury after neonatal seizures and the regulation of zinc/cPLA2 and CaMK II signaling in cerebral cortex. Epilepsy Res. 2018;146:103-111 pubmed publisher
    ..Rats were subdivided on P13 into control, control + leptin (leptin, 2 mg/kg/day, continuous 10 days), seizure (RS), and seizure + ..
  3. Gisslen T, Ennis K, Bhandari V, Rao R. Recurrent hypoinsulinemic hyperglycemia in neonatal rats increases PARP-1 and NF-κB expression and leads to microglial activation in the cerebral cortex. Pediatr Res. 2015;78:513-9 pubmed publisher
    ..hypoinsulinemic hyperglycemia of 2 h duration twice daily from postnatal (P) day 3-P12 and killed on P13. mRNA and protein expression of PARP-1/NF-κB and their downstream effectors were determined in the cerebral ..
  4. Piras A, Schiaffino L, Boido M, Valsecchi V, Guglielmotto M, De Amicis E, et al. Inhibition of autophagy delays motoneuron degeneration and extends lifespan in a mouse model of spinal muscular atrophy. Cell Death Dis. 2017;8:3223 pubmed publisher
    ..SMA II (intermediate form of the disease) which leads to motor impairment by postnatal day 5 (P5) and to death by P13. We first showed by immunoblots that Beclin 1 and LC3-II expression levels increased in the lumbar spinal cord of ..
  5. Schilter K, Reis L, Sorokina E, Semina E. Identification of an Alu-repeat-mediated deletion of OPTN upstream region in a patient with a complex ocular phenotype. Mol Genet Genomic Med. 2015;3:490-9 pubmed publisher
    ..Comparison of transcriptional activation capability of the 3 kb normal and the rearranged del(10)(p13) OPTN promoter sequences demonstrated a statistically significant decrease for the deleted allele; sequence ..
  6. Liang M, Liu J, Ji H, Chen M, Zhao Y, Li S, et al. A Aconitum coreanum polysaccharide fraction induces apoptosis of hepatocellular carcinoma (HCC) cells via pituitary tumor transforming gene 1 (PTTG1)-mediated suppression of the P13K/Akt and activation of p38 MAPK signaling pathway and displays antit. Tumour Biol. 2015;36:7085-91 pubmed publisher
    ..and in vivo, which may be through, at least partly, repression of PTTG1 and then followed by the inactivation of P13/Akt and activation of p38 MARK signaling pathways...
  7. Saile N, Schwarz L, Eißenberger K, Klumpp J, Fricke F, Schmidt H. Growth advantage of Escherichia coli O104:H4 strains on 5-N-acetyl-9-O-acetyl neuraminic acid as a carbon source is dependent on heterogeneous phage-Borne nanS-p esterases. Int J Med Microbiol. 2018;308:459-468 pubmed publisher
    ..Furthermore, successive deletion of all nanS-p alleles, subsequent complementation with recombinant NanS-p13-His, and in vitro co-culturing experiments with the commensal E. coli strain AMC 198 were conducted...
  8. Herzig J, Bullinger L, Tasdogan A, Zimmermann P, Schlegel M, Teleanu V, et al. Protein phosphatase 4 regulatory subunit 2 (PPP4R2) is recurrently deleted in acute myeloid leukemia and required for efficient DNA double strand break repair. Oncotarget. 2017;8:95038-95053 pubmed publisher
    We have previously identified a recurrent deletion at chromosomal band 3p14.1-p13 in patients with acute myeloid leukemia (AML)...
  9. Liu W, Hu S, Konopleva M, Khoury J, Kalhor N, Tang G, et al. De Novo MYC and BCL2 Double-hit B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) in Pediatric and Young Adult Patients Associated With Poor Prognosis. Pediatr Hematol Oncol. 2015;32:535-47 pubmed publisher
    ..All patients showed complex karyotypes associated with 8q24 abnormalities in the form of t(8;9)(q24;p13) or t(8;14)(q24;q32) and t(14;18)(q32;q21) and fluorescence in situ hybridization confirmed MYC and BCL2 ..
  10. Mohamed M, Gonzalez D, Fritchie K, Swansbury J, Wren D, Benson C, et al. Desmoplastic small round cell tumor: evaluation of reverse transcription-polymerase chain reaction and fluorescence in situ hybridization as ancillary molecular diagnostic techniques. Virchows Arch. 2017;471:631-640 pubmed publisher
    ..DSRCT is associated with a recurrent t(11;22)(p13;q12) translocation, leading to the characteristic EWSR1-WT1 gene fusion...
  11. Suganthy N, Devi K, Nabavi S, Braidy N, Nabavi S. Bioactive effects of quercetin in the central nervous system: Focusing on the mechanisms of actions. Biomed Pharmacother. 2016;84:892-908 pubmed publisher
    ..and neuronal longevity by modulating a broad number of kinase signaling cascades such as phophoinositide 3- kinase (P13-kinase), AKT/PKB tyrosine kinase and Protein kinase C (PKC)...
  12. Carrillo B, Collado P, Diaz F, Chowen J, Pérez Izquierdo M, Pinos H. Physiological and brain alterations produced by high-fat diet in male and female rats can be modulated by increased levels of estradiol during critical periods of development. Nutr Neurosci. 2019;22:29-39 pubmed publisher
    ..9% fat) or a control diet (5% fat) from gestational day 6. From postnatal (P) 6 to P13, both control and HFD groups were administered a s.c. injection of vehicle or estradiol benzoate (0...
  13. Yang Y, Wang S, Zhang Y, Zhu X. Biological effects of decreasing RBM15 on chronic myelogenous leukemia cells. Leuk Lymphoma. 2012;53:2237-44 pubmed publisher
    ..binding motif protein 15 (RBM15) was originally described as a 5' translocation partner of the MAL gene in t(1;22)(p13;q13)infant acute megakaryocytic leukemia...
  14. Kim K, Rutherford M. Maturation of NaV and KV Channel Topographies in the Auditory Nerve Spike Initiator before and after Developmental Onset of Hearing Function. J Neurosci. 2016;36:2111-8 pubmed publisher
    ..1 which was not enriched at juxtaparanodes until approximately P13, concurrent with the developmental onset of acoustic hearing function...
  15. Del Castillo M, Chibon F, Arnould L, Croce S, Ribeiro A, Perot G, et al. Secretory Breast Carcinoma: A Histopathologic and Genomic Spectrum Characterized by a Joint Specific ETV6-NTRK3 Gene Fusion. Am J Surg Pathol. 2015;39:1458-67 pubmed publisher
    ..breast carcinoma with distinctive morphologic features and a recurrent specific chromosomal translocation t(12;15)(p13;q25), usually of low histologic grade and favorable prognosis...
  16. Georgieva E. Non-Structural Proteins from Human T-cell Leukemia Virus Type 1 in Cellular Membranes-Mechanisms for Viral Survivability and Proliferation. Int J Mol Sci. 2018;19: pubmed publisher
    ..herein is the current knowledge about the functions of the membrane-associated p8I, p12I, and p13II regulatory non-structural proteins...
  17. Yu Y, Song P, Mei J, An Z, Zhou X, Li F, et al. [Clinicopathologic Characteristics and Outcome of Isolated Ovarian Relapse in Adolescent with Acute Lymphoblastic Leukemia]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2016;24:1354-1359 pubmed publisher
    ..BM cytogenetic analysis and fusion gene screening revealed t(1;19)(q23;p13) and E2A/PBX1...
  18. Chinnadurai S, Gandhirajan D, Srinivasan A, Kesavamurthy B, Ranganathan L, Pamidimukkala V. Predicting falls in multiple sclerosis: Do electrophysiological measures have a better predictive accuracy compared to clinical measures?. Mult Scler Relat Disord. 2018;20:199-203 pubmed publisher
    ..VEMP and SEP tests were done and the baseline P13/N23 cVEMP latencies, N10 oVEMP latency, and P37 lower limb SEP latency were obtained...
  19. Yeates L, Ingles J, Gray B, Singarayar S, Sy R, Semsarian C, et al. A balanced translocation disrupting SCN5A in a family with Brugada syndrome and sudden cardiac death. Heart Rhythm. 2019;16:231-238 pubmed publisher
    ..2;p13)...
  20. Ikeda Y, Kato Inui T, Tagami A, Maekawa M. Expression of progesterone receptor, estrogen receptors α and β, and kisspeptin in the hypothalamus during perinatal development of gonad-lacking steroidogenic factor-1 knockout mice. Brain Res. 2019;1712:167-179 pubmed publisher
    ..Diethylstilbestrol exposure during P0-P6 and P7-P13 increased POA PR and ERβ, and decreased POA ERα and ARC kisspeptin levels at P7 and/or P14 in both sexes of KO ..
  21. Margolskee E, Saab J, Geyer J, Aledo A, Mathew S. A Novel Variant t(1;22) Translocation - ins(22;1)(q13;p13p31) - in a Child with Acute Megakaryoblastic Leukemia. Am J Case Rep. 2017;18:422-426 pubmed
    BACKGROUND The reciprocal translocation t(1;22)(p13;q13) involving the RBM15 and MKL1 genes is an uncommon abnormality that occurs in a subset of acute myeloid leukemia with megakaryocytic differentiation (AMKL)...
  22. Hackett T, Clause A, Takahata T, Hackett N, Polley D. Differential maturation of vesicular glutamate and GABA transporter expression in the mouse auditory forebrain during the first weeks of hearing. Brain Struct Funct. 2016;221:2619-73 pubmed publisher
    ..medial geniculate body (MGB) of developing mice (P7, P11, P14, P21, adult) before and after ear canal opening (~P11-P13)...
  23. Wu J, Pi X, Ye Z. Pre-B acute lymphoblastic leukemia with t(1;19) in an adult initially presenting as hematuria and bilateral renal enlargement: a case report and literature review. Clin Nephrol Case Stud. 2017;5:60-65 pubmed publisher
    ..Translocation (1;19)(q23;p13) is one of the most common chromosomal abnormalities in patients with ALL and is observed in 5 - 6% of children ..
  24. Gomez Cabrero D, Almgren M, Sjöholm L, Hensvold A, Ringh M, Tryggvadottir R, et al. High-specificity bioinformatics framework for epigenomic profiling of discordant twins reveals specific and shared markers for ACPA and ACPA-positive rheumatoid arthritis. Genome Med. 2016;8:124 pubmed
    ..RA twin pairs were adjusted for cell type, the analysis disclosed one significant DMR, associated with the EXOSC1 gene...
  25. Deng H, Qianqian G, Ting J, Aimin Y. miR-539 enhances chemosensitivity to cisplatin in non-small cell lung cancer by targeting DCLK1. Biomed Pharmacother. 2018;106:1072-1081 pubmed publisher
    ..We also found that P13 K/AKT/mTOR signaling pathway was also involved in miR-539/DCLK1 axis -mediated chemosensitivity in DDP-resistant ..
  26. Dettloff J, Seethala R, Stevens T, Brandwein Gensler M, Centeno B, Otto K, et al. Mammary Analog Secretory Carcinoma (MASC) Involving the Thyroid Gland: A Report of the First 3 Cases. Head Neck Pathol. 2017;11:124-130 pubmed publisher
    ..Secretory Carcinoma (MASC) is a recently defined type of salivary gland carcinoma characterized by a t(12;15)(p13;q25) resulting in an ETV6-NTRK3 fusion gene...
  27. Hoa Tran T, Nakagomi T, Sano D, Sherchand J, Pandey B, Cunliffe N, et al. Molecular epidemiology of noroviruses detected in Nepalese children with acute diarrhea between 2005 and 2011: increase and predominance of minor genotype GII.13. Infect Genet Evol. 2015;30:27-36 pubmed publisher
    ..Pm, but the period 2 strains possessed GII.P13, GII.P16, and GII.P21. Together with recent reports on the predominance of GII.P13/GII.13 and GII.P16/GII...
  28. Balanzá R, Arrangoiz R, Cordera F, Muñoz M, Luque de León E, Moreno E, et al. Mammary analog secretory carcinoma of the parotid gland: A case report and literature review. Int J Surg Case Rep. 2015;16:187-91 pubmed publisher
    ..The patient will have a close follow up. The presence of t(12;15) (p13;q25) translocation which results in the ETV6-NTRK3 gene fusion or positive immunochemical studies for STAT5, ..
  29. Prieto Granada C, Inagaki H, Mueller J. Thymic Mucoepidermoid Carcinoma: Report of a Case With CTRC1/3-MALM2 Molecular Studies. Int J Surg Pathol. 2015;23:277-83 pubmed publisher
    ..The recently described fusions, t(11;19)(q21;p13) CREB (cAMP response element-binding protein)-regulated transcription coactivator 1 and MAML2, mastermind-like gene ..
  30. Cai Q, Jeannet R, Hua W, Cook G, Zhang B, Qi J, et al. CBF?-SMMHC creates aberrant megakaryocyte-erythroid progenitors prone to leukemia initiation in mice. Blood. 2016;128:1503-15 pubmed publisher
    ..Inv(16)(p13q22) or t(16;16)(p13.1;q22), one of the most common cytogenetic abnormalities in AML, leads to expression of a fusion protein CBF?-SMMHC ..
  31. Włodarczyk M, Fichna J, Sobolewska Włodarczyk A. Pharmacology and metabolism of infliximab biosimilars - A new treatment option in inflammatory bowel diseases. Pharmacol Rep. 2016;68:797-801 pubmed publisher
    ..cheaper biosimilar versions of the originator products are being developed, such as the infliximab biosimilar CT-P13. Position statements from several scientific societies and some experts in their reviews have expressed concerns to ..
  32. Neveu B, Spinella J, Richer C, Lagacé K, Cassart P, Lajoie M, et al. CLIC5: a novel ETV6 target gene in childhood acute lymphoblastic leukemia. Haematologica. 2016;101:1534-1543 pubmed
    The most common rearrangement in childhood precursor B-cell acute lymphoblastic leukemia is the t(12;21)(p13;q22) translocation resulting in the ETV6-AML1 fusion gene...
  33. Taxt A, Diaz Y, Aasland R, Clements J, Nataro J, Sommerfelt H, et al. Towards Rational Design of a Toxoid Vaccine against the Heat-Stable Toxin of Escherichia coli. Infect Immun. 2016;84:1239-1249 pubmed publisher
    ..L9 strongly suggests that it is a novel receptor-interacting residue, in addition to the previously identified N12, P13, and A14 residues...
  34. Kumar K, Chen W, Koduru P, Luu H. Myeloid and lymphoid neoplasm with abnormalities of FGFR1 presenting with trilineage blasts and RUNX1 rearrangement: a case report and review of literature. Am J Clin Pathol. 2015;143:738-48 pubmed publisher
    ..We report a case of a patient with a novel t(17;21)(p13;q22) with RUNX1 rearrangement and trilineage blasts...
  35. Goud T, Al Salmani K, Al Harasi S, Al Musalhi M, Wasifuddin S, Rajab A. Importance of FISH combined with Morphology, Immunophenotype and Cytogenetic Analysis of Childhood/ Adult Acute Lymphoblastic Leukemia in Omani Patients. Asian Pac J Cancer Prev. 2015;16:7343-50 pubmed
    ..5%) was the highest observed structural abnormality followed by t(12;21)(p13.3;q22) resulting in ETV6/RUNX1 fusion (5.4%) and t(9;22)(q34.1;q11.2) resulting in BCR/ABL1 fusion (4.3%)...
  36. Stoskus M, Eidukaite A, Griskevicius L. Defining the significance of IGF2BP1 overexpression in t(12;21)(p13;q22)-positive leukemia REH cells. Leuk Res. 2016;47:16-21 pubmed publisher
    ..IGF2BP1 has also been identified to be exclusively specific for t(12;21)(p13;q22)-positive acute lymphoblastic leukemia (ALL) but biological significance of IGF2BP1 overexpression has not been ..
  37. Hindocha N, Wilson M, Pring M, Hughes C, Thomas S. Mammary analogue secretory carcinoma of the salivary glands: a diagnostic dilemma. Br J Oral Maxillofac Surg. 2017;55:290-292 pubmed publisher
    ..these by differences in immunohistochemical profile and the identification of an ETV6-NTRK3 translocation (12;15)(p13;q25), which is also found in secretory carcinomas of the breast...
  38. Perea J, García J, Pérez J, Rueda D, Arriba M, Rodríguez Y, et al. NOMO-1 gene is deleted in early-onset colorectal cancer. Oncotarget. 2017;8:24429-24436 pubmed publisher
    To characterize clinical features of a recurrent alteration in 16p13.12-p13.11 in Colorectal Cancer (CRC), mainly in Early-onset subgroup (EOCRC), and to assess the status of NOMO1, a gene located in that region, we analyzed differential ..
  39. Liu K, Lu X, Cheng Y, Klieb H, Ng S, McNeil K, et al. An actionable test using loss of heterozygosity in identifying high-risk oral premalignant lesions. Oral Surg Oral Med Oral Pathol Oral Radiol. 2017;: pubmed publisher
    ..8). Compared with nonprogressors (n = 61), anatomic site and MR patterns (LOH at 9 p21, 3 p14, or 17 p13) were independent risk factors...
  40. Parsa M, Mohammadkhani G, Hajabolhassani F, Jalaee S, Zakeri H. Cervical and ocular vestibular evoked myogenic potentials in multiple sclerosis participants. Med J Islam Repub Iran. 2015;29:164 pubmed
    ..The latency of N1-P1 and P13 in MS participants with and without infratentorial plaques were significantly prolonged compared to normal controls ..
  41. Santos T, de Oliveira A, Dantas J, Salgueiro C, Cordas C. Thermodynamic and kinetic characterization of PccH, a key protein in microbial electrosynthesis processes in Geobacter sulfurreducens. Biochim Biophys Acta. 2015;1847:1113-8 pubmed publisher
    ..4 (pKred2). Based on the inspection of PccH structure, these centers were assigned to heme propionic acids P13 and P17, respectively...
  42. Miao Y, Wang R, Fan L, Qiu H, Wu Y, Chen Y, et al. Detection of t(12;14)(p13;q32) in a patient with IGH-CCND1 negative mantle cell lymphoma resembling ultra-high risk chronic lymphocytic leukemia. Int J Clin Exp Pathol. 2015;8:7494-8 pubmed
    T(12;14)(p13;q32) is a rare recurrent chromosomal translocation, which has only been identified in a small subgroup of mantle cell lymphoma (MCL) without typical t(11;14)(q13;q32)...
  43. Özgür A, Serdaroğlu Beyazal M, Terzi S, Coşkun Z, Dursun E. Vestibular evoked myogenic potentials in patients with ankylosing spondylitis. Eur Arch Otorhinolaryngol. 2016;273:2953-7 pubmed publisher
    ..VEMP wave latency, P13-N23 wave amplitude, and VEMP asymmetry ratio (VAR) values were compared between the groups...
  44. Yu M, Cui F, Jia H, Zhou C, Yang Y, Zhang H, et al. Aberrant purine metabolism in allergic asthma revealed by plasma metabolomics. J Pharm Biomed Anal. 2016;120:181-9 pubmed publisher
    ..Among them, 6 (dodecanoic acid (P1), myristic acid (P2), phytosphingosine (P3), sphinganine (P4), inosine (P13) and taurocholic acid (P15)) were first reported to have potential relevance in the pathogenesis of experimental ..
  45. Hu X, Moon J, Li S, Xu W, Wang X, Liu Y, et al. Amplification and overexpression of CTTN and CCND1 at chromosome 11q13 in Esophagus squamous cell carcinoma (ESCC) of North Eastern Chinese Population. Int J Med Sci. 2016;13:868-874 pubmed
    ..3-qter, 3q13.11-qter, 5pter-p11, 7pter-p15.3, 7p12.1-p11.2, 7q11-q11.2, 8p12-qter, 11q13.2-q13.3, 12pter-p13.31, 17q24.2, 20q11.21-qter, and 22q11.21-q11.22 whereas the recurrent losses were 3pter-p11.1, 4pter-p12, 4q28...
  46. Han N, Kuang L, Zhu B, Hua L, Li W. [Delineating a case with a complex karyotype by using combined genetic techniques]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2017;34:559-562 pubmed publisher
    ..The child was found to have a karyotype of 46, XX, t(1;2) (q25;q21), t(7;20) (q21;p13). HT-NGS has detected a microdeletion at 2q21.3 and 7q21.11, respectively, which were verified by FISH...
  47. Du X, GOMEZ C. Spinocerebellar [corrected] Ataxia Type 6: Molecular Mechanisms and Calcium Channel Genetics. Adv Exp Med Biol. 2018;1049:147-173 pubmed publisher
    ..1-p13.2. Normal alleles have 4-18 repeats, while alleles causing disease contain 19-33 repeats...
  48. Allerdice M, Pritt B, Sloan L, Paddock C, Karpathy S. A real-time PCR assay for detection of the Ehrlichia muris-like agent, a newly recognized pathogen of humans in the upper Midwestern United States. Ticks Tick Borne Dis. 2016;7:146-149 pubmed publisher
    ..Here, we describe the development and validation of a p13-based quantitative real-time PCR TaqMan assay to detect EMLA in blood or tissues of ticks, humans, and rodents...
  49. Macambira Y, Carnaúba A, Fernandes L, Bueno N, Menezes P. Aging and wave-component latency delays in oVEMP and cVEMP: a systematic review with meta-analysis. Braz J Otorhinolaryngol. 2017;83:475-487 pubmed publisher
    ..and an increase in latencies of the vestibular evoked myogenic potentials, especially the prolongation of p13 latency. Moreover, many investigations have found no significant differences in latencies with advancing age...
  50. Chen J, Zhang L, Jin Q, Su C, Zhao L, Liu X, et al. Bioremediation of phenol in soil through using a mobile plant-endophyte system. Chemosphere. 2017;182:194-202 pubmed publisher
    ..fluorescens streptomycin-resistant P13 strain. The corn-TP13-P13 (CTP) system had higher degradation activity than other plant-endophyte systems...
  51. Strand V, Balsa A, Al Saleh J, Barile Fabris L, Horiuchi T, Takeuchi T, et al. Immunogenicity of Biologics in Chronic Inflammatory Diseases: A Systematic Review. BioDrugs. 2017;31:299-316 pubmed publisher
    ..the highest overall rates were reported with infliximab (0-83%), adalimumab (0-54%), and infliximab biosimilar CT-P13 (21-52%), and the lowest with secukinumab (0-1%), ustekinumab (1-11%), etanercept (0-13%), and golimumab (0-19%)...
  52. de Braekeleer M, Le Bris M, De Braekeleer E, Basinko A, Morel F, Douet Guilbert N. 3q26/EVI1 rearrangements in myeloid hemopathies: a cytogenetic review. Future Oncol. 2015;11:1675-86 pubmed publisher
    ..They include inv(3)(q21q26), t(3;3)(q21;q26), t(3;21)(q26;q22), t(3;12)(q26;p13) and t(2;3)(p15-23;q26). However, many other chromosomal rearrangements involving 3q26/EVI1 have been identified...
  53. Tseng C, Young Y. Eliciting Cervical Vestibular-Evoked Myogenic Potentials by Bone-Conducted Vibration via Various Tapping Sites. Ear Hear. 2016;37:235-42 pubmed publisher
    ..Mean p13 and n23 latencies from the Cz tapping were significantly longer than those from the Fz tapping, but not longer than ..
  54. Chang S, Hanauer S. Extrapolation and Interchangeability of Infliximab and Adalimumab in Inflammatory Bowel Disease. Curr Treat Options Gastroenterol. 2017;15:53-70 pubmed publisher
    ..Neither CT-P13 (infliximab biosimilar) nor ABP 501 (adalimumab biosimilar) was clinically tested in patients with inflammatory ..
  55. Kuru D, Tarkan Argüden Y, Ar M, Çırakoğlu A, Ongoren S, Yilmaz S, et al. Variant Philadelphia translocations with different breakpoints in six chronic myeloid leukemia patients. Turk J Haematol. 2011;28:186-92 pubmed publisher
    ..as follows: t(7;22)(p22;q11), t(9;22;15)(q34;q11;q22), t(15;22)(p11;q11), t(1;9;22;3)(q24;q34;q11;q21), t(12;22)(p13;q11), and t(4;8;9;22)(q11;q13;q34;q11)...
  56. Reinisch W, Jahnsen J, Schreiber S, Danese S, Panés J, Balsa A, et al. Evaluation of the Cross-reactivity of Antidrug Antibodies to CT-P13 and Infliximab Reference Product (Remicade): An Analysis Using Immunoassays Tagged with Both Agents. BioDrugs. 2017;31:223-237 pubmed publisher
    During two pivotal clinical trials of the infliximab biosimilar CT-P13 (PLANETAS and PLANETRA), antidrug antibodies (ADAs) and neutralising antibodies (NAbs) were detected in the sera of patients treated with CT-P13 and the reference ..
  57. Emami S, Farahani F. Saccular dysfunction in children with sensorineural hearing loss and auditory neuropathy/auditory dys-synchrony. Acta Otolaryngol. 2015;135:1298-303 pubmed publisher
    ..analysis of an independent t-test between AN/AD ears as compared to non-AN/AD ears of these 13 children showed that the mean latencies of p13 and the mean latencies of n23 and the mean peak-to-peak amplitude had significant differences.
  58. Mohan H, Gasner M, Ramesh N, Unniappan S. Ghrelin, ghrelin-O-acyl transferase, nucleobindin-2/nesfatin-1 and prohormone convertases in the pancreatic islets of Sprague Dawley rats during development. J Mol Histol. 2016;47:325-36 pubmed publisher
    ..Both PC1/3 and PC2 are co-expressed with NUCB2/nesfatin-1 on embryonic (E) day E21, P13, P20...
  59. Skalova A, Gnepp D, Lewis J, Hunt J, Bishop J, Hellquist H, et al. Newly Described Entities in Salivary Gland Pathology. Am J Surg Pathol. 2017;41:e33-e47 pubmed publisher
    ..distinctive low-grade malignant salivary cancer that harbors a characteristic chromosomal translocation, t(12;15) (p13;q25), resulting in an ETV6-NTRK3 fusion...
  60. Ma E, Wan T, Au C, Ho D, Ma S, Ng M, et al. Next-generation sequencing and molecular cytogenetic characterization of ETV6-LYN fusion due to chromosomes 1, 8 and 12 rearrangement in acute myeloid leukemia. Cancer Genet. 2017;218-219:15-19 pubmed publisher
    ..First, there was a balanced translocation t(1;12)(p13;p13.2) in which the ETV6 was split between der(1) and der(12). Second, an inverted insertion of 8q12.1~q24...
  61. Canton A, Nishi M, Furuya T, Roela R, Jorge A. Good response to long-term therapy with growth hormone in a patient with 9p trisomy syndrome: A case report and review of the literature. Am J Med Genet A. 2016;170A:1046-9 pubmed publisher
    ..SNP array data indicated absence of mosaicism [arr 9p24.3-p13.1 (203,861-38,787,480) x3]. By the age of 8.3 years, the patient had persistent short stature (-2...
  62. Carli G, Visco C, Falisi E, Perbellini O, Novella E, Giaretta I, et al. Evans syndrome secondary to chronic lymphocytic leukaemia: presentation, treatment, and outcome. Ann Hematol. 2016;95:863-70 pubmed publisher
    ..prognostic factors like ZAP-70 expression, unmutated immunoglobulin heavy chain variable region gene status, 17-p13 deletion and TP53 gene mutations...
  63. Wafa A, As sad M, Liehr T, Aljapawe A, Al Achkar W. Childhood pre-B cell acute lymphoblastic leukemia with translocation t(1;19)(q21.1;p13.3) and two additional chromosomal aberrations involving chromosomes 1, 6, and 13: a case report. J Med Case Rep. 2017;11:94 pubmed publisher
    The translocation t(1;19)(q23;p13), which results in the TCF3-PBX1 chimeric gene, is one of the most frequent rearrangements observed in B cell acute lymphoblastic leukemia...
  64. Anbarasan C, Bavanilatha M, Latchumanadhas K, Ajit Mullasari S. ICAM-1 molecular mechanism and genome wide SNP's association studies. Indian Heart J. 2015;67:282-7 pubmed publisher
    ..The key molecule is the ICAM-1, member of the adhesion immunoglobulin super family that maps to chromosome 19 p13.2-p13...
  65. Gecse K, Lovász B, Farkas K, Banai J, Bene L, Gasztonyi B, et al. Efficacy and Safety of the Biosimilar Infliximab CT-P13 Treatment in Inflammatory Bowel Diseases: A Prospective, Multicentre, Nationwide Cohort. J Crohns Colitis. 2016;10:133-40 pubmed publisher
    Biosimilar infliximab CT-P13 is approved for all indications of the originator product in Europe. Prospective data on its efficacy, safety, and immunogenicity in inflammatory bowel diseases are lacking...
  66. Malinverni A, Colovati M, Perez A, Caneloi T, Oliveira H, Kosyakova N, et al. Unusual Duplication in the Pericentromeric Region of Chromosome 9 in a Patient with Phenotypic Alterations. Cytogenet Genome Res. 2016;150:100-105 pubmed publisher
    ..2::q21.11?q12::p11.2?p13.2::q12?p11.2::q21.11?qter), that has not been described before...
  67. Tsukanov K, Krasnenko A, Plakhina D, Korostin D, Churov A, Druzhilovskaya O, et al. [A bioinformatic pipeline for NGS data analysis and mutation calling in human solid tumors]. Biomed Khim. 2017;63:413-417 pubmed publisher
    ..Low-quality 3¢-nucleotides were removed. After that the reads were mapped to the reference genome hg19 (GRCh37.p13) by BWA. The SAMtools program was used for exclusion of duplicates. MuTect was used for SNV calling...
  68. Hoang L, Chiang S, Lee C. Endometrial stromal sarcomas and related neoplasms: new developments and diagnostic considerations. Pathology. 2018;50:162-177 pubmed publisher
    ..was recently re-introduced in the classification of endometrial stromal tumours after the discovery of t(10;17)(q22;p13) resulting in YWHAE-NUTM2A/B fusion and is associated with distinct morphological characteristics...
  69. Mishra R, Paththinige C, Sirisena N, Nanayakkara S, Kariyawasam U, Dissanayake V. Partial trisomy 16q21?qter due to an unbalanced segregation of a maternally inherited balanced translocation 46,XX,t(15;16)(p13;q21): a case report and review of literature. BMC Pediatr. 2018;18:4 pubmed publisher
    ..The proband was trisomic for 16q21?qter chromosomal region with a karyotype, 46,XX,der(15)t(15;16)(p13;q21)mat...
  70. Argüelles Arias F, Guerra Veloz M, Perea Amarillo R, Vilches Arenas A, Castro Laria L, Maldonado Pérez B, et al. Effectiveness and Safety of CT-P13 (Biosimilar Infliximab) in Patients with Inflammatory Bowel Disease in Real Life at 6 Months. Dig Dis Sci. 2017;62:1305-1312 pubmed publisher
    CT-P13 is a biosimilar of Remicade®, an agent approved in some countries for use in inflammatory bowel disease (IBD)...
  71. Moots R, Azevedo V, Coindreau J, Dorner T, Mahgoub E, Mysler E, et al. Switching Between Reference Biologics and Biosimilars for the Treatment of Rheumatology, Gastroenterology, and Dermatology Inflammatory Conditions: Considerations for the Clinician. Curr Rheumatol Rep. 2017;19:37 pubmed publisher
    ..Fifty-three switching studies were identified. Infliximab publications covered CT-P13 (25 studies), SB2 (1), infliximab NK (1), and unspecified infliximab biosimilars (2)...
  72. Han J, Ji L, Shen Y, Wu X, Xu D, Chen L. Emergence and predominance of norovirus GII.17 in Huzhou, China, 2014-2015. Virol J. 2015;12:139 pubmed publisher
    ..Phylogenetic analysis confirmed the presence of five recombinant strains in Huzhou. Recombinants GII.P13/GII.17 and GII.P12/GII.4 were newly detected in China. The GII.P13/GII...
  73. Imoto N, Hayakawa F, Kurahashi S, Morishita T, Kojima Y, Yasuda T, et al. B Cell Linker Protein (BLNK) Is a Selective Target of Repression by PAX5-PML Protein in the Differentiation Block That Leads to the Development of Acute Lymphoblastic Leukemia. J Biol Chem. 2016;291:4723-31 pubmed publisher
    ..The fusion gene PAX5-PML has been identified in acute lymphoblastic leukemia with chromosomal translocation t(9;15)(p13;q24)...
  74. Tijchon E, van Emst L, Yuniati L, van Ingen Schenau D, Gerritsen M, van der Meer L, et al. Tumor suppressor BTG1 limits activation of BCL6 expression downstream of ETV6-RUNX1. Exp Hematol. 2018;60:57-62.e3 pubmed publisher
    Translocation t(12;21) (p13;q22), giving rise to the ETV6-RUNX1 fusion gene, is the most common genetic abnormality in childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL)...
  75. Raijmakers R, Egberts W, van Venrooij W, Pruijn G. The association of the human PM/Scl-75 autoantigen with the exosome is dependent on a newly identified N terminus. J Biol Chem. 2003;278:30698-704 pubmed
    ..This suggests that this basic element of PM/Scl-75 plays a role in targeting the exosome to the nucleolus. ..
  76. Komaki Y, Yamada A, Komaki F, Micic D, Ido A, Sakuraba A. Systematic review with meta-analysis: the efficacy and safety of CT-P13, a biosimilar of anti-tumour necrosis factor-? agent (infliximab), in inflammatory bowel diseases. Aliment Pharmacol Ther. 2017;45:1043-1057 pubmed publisher
    ..Biosimilars of anti-tumour necrosis factor (TNF)-? agents have now become clinically available for the treatment of inflammatory bowel diseases (IBD)...
  77. Cipriani V, Silva R, Arno G, Pontikos N, Kalhoro A, Valeina S, et al. Duplication events downstream of IRX1 cause North Carolina macular dystrophy at the MCDR3 locus. Sci Rep. 2017;7:7512 pubmed publisher
    ..The disorder has been linked to two loci, MCDR1 (chromosome 6q16) and MCDR3 (chromosome 5p15-p13)...
  78. Gauernack A, Lassek C, Hou L, Dzieciolowski J, Evguenieva Hackenberg E, Klug G. Nop5 interacts with the archaeal RNA exosome. FEBS Lett. 2017;: pubmed publisher
    ..complex responsible for phosphorolytic degradation and tailing of RNA, has an RNA-binding platform containing Rrp4, Csl4 and DnaG...
  79. Yoo D. Comparative effectiveness of the biosimilar CT-P13. J Comp Eff Res. 2017;6:693-712 pubmed publisher
    The first biosimilar infliximab, CT-P13 (infliximab-dyyb) has been used for the treatment of inflammatory diseases for 4 years...
  80. Zeilbeck L, Müller B, Leopold S, Senturk B, Langmann T, Tamm E, et al. Norrin mediates angiogenic properties via the induction of insulin-like growth factor-1. Exp Eye Res. 2016;145:317-326 pubmed publisher
    ..Furthermore, at P13, one day after the mice had returned to normoxic conditions, IGF-1 levels were significantly higher in transgenic ..
  81. Wolf I, Bouquet C, Melchers F. cDNA-library testing identifies transforming genes cooperating with c-myc in mouse pre-B cells. Eur J Immunol. 2016;46:2555-2565 pubmed publisher
    ..This transcript was identified as a shortened form of the Exosc1 gene, encoding the RNA exosome complex component CSL4. Transplantations of double c-myc/Exosc1 short-form- or c-myc/Exosc1 full-length-transgenic cells into ..
  82. Falk S, Bonneau F, Ebert J, Kögel A, Conti E. Mpp6 Incorporation in the Nuclear Exosome Contributes to RNA Channeling through the Mtr4 Helicase. Cell Rep. 2017;20:2279-2286 pubmed publisher
  83. Matse J, Veerman E, Bolscher J, Leemans C, Ylstra B, Bloemena E. High number of chromosomal copy number aberrations inversely relates to t(11;19)(q21;p13) translocation status in mucoepidermoid carcinoma of the salivary glands. Oncotarget. 2017;8:69456-69464 pubmed publisher
    ..The presence of the t(11;19)(q21;p13) translocation in a subset of MECs has raised interest in genomic aberrations in MEC...
  84. Perez J, Fernando C, Nosach R, Huang Y, Harding J, Hill J. In vitro attenuation of a virulent swine isolate of Brachyspira hampsonii. Pathog Dis. 2018;76: pubmed publisher
    Brachyspira hampsonii causes dysentery-like disease in infected pigs. Serial passage of a virulent swine isolate (P13) one-hundred times in laboratory culture medium was conducted to produce an attenuated strain, and to identify genomic ..
  85. Chen S, Nagel S, Schneider B, Dai H, Geffers R, Kaufmann M, et al. A new ETV6-NTRK3 cell line model reveals MALAT1 as a novel therapeutic target - a short report. Cell Oncol (Dordr). 2018;41:93-101 pubmed publisher
    Previously, the chromosomal translocation t(12;15)(p13;q25) has been found to recurrently occur in both solid tumors and leukemias...
  86. Kavasoğlu G, Gokcay F, Yuceyar N, Celebisoy N. Cervical vestibular-evoked myogenic potentials in patients with multiple sclerosis: sensitive in detecting brainstem involvement?. Neurol Sci. 2018;39:365-371 pubmed publisher
    ..Thirty-one age- and sex-matched healthy controls constituted the control group. The latencies of peaks p13 and n23 and peak-to-peak amplitude of p13-n23 were measured...
  87. Wasmuth E, Januszyk K, Lima C. Structure of an Rrp6-RNA exosome complex bound to poly(A) RNA. Nature. 2014;511:435-9 pubmed publisher
    ..Although path selection to Rrp6 or Rrp44 is stochastic in vitro, the fate of a particular RNA may be determined in vivo by the manner in which cofactors present RNA to the RNA exosome. ..
  88. Becker M, Liu K, Tirado C. The t(12;21)(p13;q22) in Pediatric B-Acute Lymphoblastic Leukemia: An Update. J Assoc Genet Technol. 2017;43:198 pubmed
    ..In the section Secondary genetic aberrations we would like to add that: Deletions of 11q23 are observed in 5-6% of cases (Raynaud et al., 1999; Attarbaschi et al., 2004; Alvarez et al., 2005; Forestier et al., 2007)...
  89. Takai S, Kawakami H, Nakayama T, Yamada K, Nakamura S. Localization of the gene encoding the human L-glutamate transporter (GLT-1) to 11p11.2-p13 by fluorescence in situ hybridization. Hum Genet. 1996;97:387-9 pubmed
    ..In the present study, the GLT-1 subtype was mapped to human chromosome 11p11.2-p13 by fluorescence in situ hybridization. The possible clinical implications of this finding are discussed.
  90. Asp L, Holtze M, Powell S, Karlsson H, Erhardt S. Neonatal infection with neurotropic influenza A virus induces the kynurenine pathway in early life and disrupts sensorimotor gating in adult Tap1-/- mice. Int J Neuropsychopharmacol. 2010;13:475-85 pubmed publisher
    ..on postnatal day (P)3 or P4, the levels of several transcripts in the kynurenine pathway were altered at P7, P13 and P24...
  91. Ferreira E, Barros B, de Souza J, Almeida R, Torrezan G, Garcia S, et al. A genomic case study of desmoplastic small round cell tumor: comprehensive analysis reveals insights into potential therapeutic targets and development of a monitoring tool for a rare and aggressive disease. Hum Genomics. 2016;10:36 pubmed
    ..A specific translocation, t(11;22)(p13;q12), resulting in EWS and WT1 gene fusion is the only recurrent molecular hallmark and no other genetic factor has ..
  92. Raijmakers R, Egberts W, van Venrooij W, Pruijn G. Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring. J Mol Biol. 2002;323:653-63 pubmed