EXOG

Summary

Gene Symbol: EXOG
Description: exo/endonuclease G
Alias: ENDOGL1, ENDOGL2, ENGL, ENGL-a, ENGL-b, ENGLA, ENGLB, nuclease EXOG, mitochondrial, endo G-like 1, endo/exonuclease (5'-3'), endonuclease G-like, endonuclease G-like 1, endonuclease G-like 2
Species: human
Products:     EXOG

Top Publications

  1. Moritani M, Nomura K, Tanahashi T, Osabe D, Fujita Y, Shinohara S, et al. Genetic association of single nucleotide polymorphisms in endonuclease G-like 1 gene with type 2 diabetes in a Japanese population. Diabetologia. 2007;50:1218-27 pubmed
    ..000046, odds ratio = 1.33, 95% CI 1.16-1.53) in intron 5 of the endonuclease G-like 1 (ENDOGL1) gene. Systematic dense SNPs approach identified a susceptibility linkage disequilibrium (LD) block of 116...
  2. Daigo Y, Isomura M, Nishiwaki T, Tamari M, Ishikawa S, Kai M, et al. Characterization of a 1200-kb genomic segment of chromosome 3p22-p21.3. DNA Res. 1999;6:37-44 pubmed
    ..One (designated ENGL) of the novel sequences was found to encode an amino-acid sequence homologous to the family of DNA/RNA ..
  3. Cymerman I, Chung I, Beckmann B, Bujnicki J, Meiss G. EXOG, a novel paralog of Endonuclease G in higher eukaryotes. Nucleic Acids Res. 2008;36:1369-79 pubmed publisher
    ..Here we show that higher eukaryotes in addition to EndoG contain its paralog 'EXOG', a novel EndoG-like mitochondrial endo/exonuclease...
  4. Tann A, Boldogh I, Meiss G, Qian W, Van Houten B, Mitra S, et al. Apoptosis induced by persistent single-strand breaks in mitochondrial genome: critical role of EXOG (5'-EXO/endonuclease) in their repair. J Biol Chem. 2011;286:31975-83 pubmed publisher
    ..Here, we show that EXOG, a 5'-exo/endonuclease and unique to the mitochondria unlike FEN1 or DNA2, which, like EXOG, has been implicated in ..
  5. Sykora P, Wilson D, Bohr V. Repair of persistent strand breaks in the mitochondrial genome. Mech Ageing Dev. 2012;133:169-75 pubmed publisher
    ..and CSB), aprataxin (APTX), tryosyl-DNA phosphodiesterase 1 (TDP1), flap endonuclease 1 (FEN-1) and exonuclease G (EXOG)...
  6. Vo P, Pantin J, Ramos C, Cook L, Cho E, Kurlander R, et al. Conditioning with rabbit versus horse ATG dramatically alters clinical outcomes in identical twins with severe aplastic anemia transplanted with the same allogeneic donor. J Hematol Oncol. 2015;8:78 pubmed publisher
    ..distinct, having significant differences in their pharmacokinetics and in vivo immunosuppressive effects [N Engl J Med 365(5):430-438, 2011]...
  7. Muschitz C, Kocijan R, Stütz V, Kaider A, Muschitz G, Resch H, et al. Vitamin D levels and comorbidities in ambulatory and hospitalized patients in Austria. Wien Klin Wochenschr. 2015;127:675-84 pubmed publisher
    ..Endocr Rev 29(6):726-776, 2008; Holick, N Engl J Med 357(3):266-281, 2007)...
  8. Hicks S, Chaiwatpongsakorn S, Costello H, McLellan J, Ray W, Peeples M. Five Residues in the Apical Loop of the Respiratory Syncytial Virus Fusion Protein F2 Subunit Are Critical for Its Fusion Activity. J Virol. 2018;92: pubmed publisher
    ..E. Walsh, Drugs Aging 22:577-587, 2005; A. R. Falsey, P. A. Hennessey, M. A. Formica, C. Cox, and E. E. Walsh, N Engl J Med 352:1749-1759, 2005)...
  9. Woodrum D, Kawashima A, Gorny K, Mynderse L. Targeted Prostate Biopsy and MR-Guided Therapy for Prostate Cancer. Adv Exp Med Biol. 2018;1096:159-184 pubmed publisher
    ..N Engl J Med 370:932-942, 2014). Therefore accurate assessment of cancer risk (i.e...

More Information

Publications97

  1. Edorh M, Agbere S, Osei safo D, Adam Z, Agbonon A, Karou D, et al. Toxicological screening of Daouri, a polyherbal formulation used in children in the Central Region of Togo. J Ethnopharmacol. 2015;164:30-4 pubmed publisher
    ..A. Juss, Odina acida (A. Rich.) Oliv.,Lophira lanceolata Tiegh, Paullinia pinnata L. and Pteleopsis suberosa Engl. & Diels...
  2. Sangweni N, Dludla P, Mosa R, Kappo A, Opoku A, Muller C, et al. Lanosteryl triterpenes from Protorhus longifolia as a cardioprotective agent: a mini review. Heart Fail Rev. 2019;24:155-166 pubmed publisher
    ..Recent findings have suggested that triterpenes isolated from Protorhus longifolia (Benrh.) Engl., a plant species endemic to Southern Africa, display strong antioxidant and antidiabetic properties that may ..
  3. Chen A, McIntyre B, De E. Management of Postoperative Lower Urinary Tract Symptoms (LUTS) After Pelvic Organ Prolapse (POP) Repair. Curr Urol Rep. 2018;19:74 pubmed publisher
    ..Neurourol Urodyn 26: 29-35, 2007], botulinum toxin, and anticholinergic therapy [Res Rep Urol 8:113-122, 2016 , N Engl J Med, 367:1803-1813, 2012]. 5...
  4. Szczesny B, Marcatti M, Zatarain J, Druzhyna N, Wiktorowicz J, Nagy P, et al. Inhibition of hydrogen sulfide biosynthesis sensitizes lung adenocarcinoma to chemotherapeutic drugs by inhibiting mitochondrial DNA repair and suppressing cellular bioenergetics. Sci Rep. 2016;6:36125 pubmed publisher
    ..normal lung epithelial cells elevated H2S stimulates mitochondrial DNA repair through sulfhydration of EXOG, which, in turn, promotes mitochondrial DNA repair complex assembly, thereby enhancing mitochondrial DNA repair ..
  5. Kamran N, Candolfi M, Baker G, Ayala M, Dzaman M, Lowenstein P, et al. Gene Therapy for the Treatment of Neurological Disorders: Central Nervous System Neoplasms. Methods Mol Biol. 2016;1382:467-82 pubmed publisher
    ..2-21.2 months post diagnosis (Stupp et al., N Engl J Med 352(10): 987-996, 2005)...
  6. O Sullivan G, de Graaf R, Black S. Just How Attractive is the ATTRACT Trial?. Cardiovasc Intervent Radiol. 2018;41:1313-1317 pubmed publisher
    ..in N Engl J Med 377:2240-2252, 2017) concluded that the addition of catheter-directed thrombolysis to standard therapy with ..
  7. Wang Z, Shi L, Ding W, Shao F, Yu J, Zhang J. Efficacy of Progesterone for Acute Traumatic Brain Injury: a Meta-analysis of Randomized Controlled Trials. Mol Neurobiol. 2016;53:7070-7077 pubmed
    ..that all the outcomes were stable after excluding Shakeri (Clin Neurol Neurosurg 115: 2019-2022, 2013) or Wright (N Engl J Med 371: 2457-2466, 2014) trials. The quality of the evidence was varied from high to low...
  8. Raffoul J, Klein A. Dual antiplatelet therapy duration after the placement of a drug-eluting stent: what are the data?. Curr Treat Options Cardiovasc Med. 2015;17:367 pubmed publisher
    ..However, recent data from the DAPT trial (Mauri et al. N Engl J Med. 371(23):2156-66, 2014) clearly demonstrated less ischemic events with 30 months of DAPT...
  9. Ghadimi B, Jo P. Cancer Gene Profiling for Response Prediction. Methods Mol Biol. 2016;1381:163-79 pubmed publisher
    ..in which patients will be treated based on the biology of their tumor and their genetic profile (Quackenbush, N Engl J Med 354:2463-72, 2006; Jensen et al...
  10. Silverstein J. Hyperglycemia induced by pasireotide in patients with Cushing's disease or acromegaly. Pituitary. 2016;19:536-43 pubmed publisher
    ..in Pituitary 17(4):320-326, 2014, 5.3 %; Colao et al. in N Engl J Med 366(10):914-924, 2012, 6.0 %). Hyperglycemia-related AEs occurred in 40...
  11. Ma Y, di Salvo M, Budisa N. Self-Directed in Cell Production of Methionine Analogue Azidohomoalanine by Synthetic Metabolism and Its Incorporation into Model Proteins. Methods Mol Biol. 2018;1728:127-135 pubmed publisher
    ..J Org Chem 67:3057-3064, 2002; Kiick et al., Angew Chem Int Ed 39:2148-2152, 2000; Budisa, Angew Chem Int Ed Engl 47:6426-6463, 2004; van Hest, J Am Chem Soc 122:1282-1288, 2000).
  12. Guardo L, Gala C, Calvo A, Aguirre A, Arango N, Fernández E, et al. Known difficult airway in a patient with pheochromocytoma: a case report. J Clin Anesth. 2016;35:411-414 pubmed publisher
    ..is a useful drug for sedation during orotracheal intubation with spontaneous ventilation in a patient with pheochromocytoma and a chronic respiratory pathology (Chin Med J (Engl) 2015;128:3143-3148, J Clin Anesth 2007; 19:370-373).
  13. Somers V, Arzt M, Bradley T, Randerath W, Tamisier R, Won C. Servo-Ventilation Therapy for Sleep-Disordered Breathing. Chest. 2018;153:1501-1502 pubmed publisher
    ..Adaptive servo-ventilation for central sleep apnea in systolic heart failure. New Engl J Med...
  14. Kepros J, Opreanu R, Samaraweera R, Briningstool A, Morrison C, Mosher B, et al. Whole body imaging in the diagnosis of blunt trauma, ionizing radiation hazards and residual risk. Eur J Trauma Emerg Surg. 2013;39:15-24 pubmed publisher
    ..the increased use of CT scanning, concerns were raised regarding the associated exposure to ionizing radiation [N Engl J Med 357:2277-2284, 2007]...
  15. Van Houten B, Hunter S, Meyer J. Mitochondrial DNA damage induced autophagy, cell death, and disease. Front Biosci (Landmark Ed). 2016;21:42-54 pubmed
    ..accumulation of certain types of mitochondrial damage, in the absence of DNA ligase III (Lig3) or exonuclease G (EXOG), can directly trigger cell death...
  16. Suslov K. Transient immunosuppression during short interruption of HAART: Another key to HIV cure in the "Berlin patient"?. Med Hypotheses. 2019;123:6-8 pubmed publisher
    ..Arguably, in the "Berlin patient" (Hütter G, et al., N Engl J Med, 2009) an induction chemotherapy-mediated transient immunosuppression episode during short interruption of ..
  17. Peeva V, Blei D, Trombly G, Corsi S, Szukszto M, Rebelo Guiomar P, et al. Linear mitochondrial DNA is rapidly degraded by components of the replication machinery. Nat Commun. 2018;9:1727 pubmed publisher
    ..We do not observe similar effects when inactivating other known mitochondrial nucleases (EXOG, APEX2, ENDOG, FEN1, DNA2, MRE11, or RBBP8)...
  18. Gandotra S, Lim K, Girousse A, Saudek V, O Rahilly S, Savage D. Human frame shift mutations affecting the carboxyl terminus of perilipin increase lipolysis by failing to sequester the adipose triglyceride lipase (ATGL) coactivator AB-hydrolase-containing 5 (ABHD5). J Biol Chem. 2011;286:34998-5006 pubmed publisher
    ..K., Lathrop, M., Lascols, O., Capeau, J., O'Rahilly, S., Magré, J., Savage, D. B., and Vigouroux, C. (2011) N. Engl. J. Med. 364, 740-748.) When overexpressed in preadipocytes, both mutants fail to inhibit basal lipolysis...
  19. Girometti R, Fabris F. Informational analysis: a Shannon theoretic approach to measure the performance of a diagnostic test. Med Biol Eng Comput. 2015;53:899-910 pubmed publisher
    ..We apply our model to a study by Pisano et al. (N Engl J Med 353(17):1773-1783, 2005), who compared digital versus film mammography, in diagnosing breast cancer in a ..
  20. Hünniger T, Felbinger C, Wessels H, Mast S, Hoffmann A, Schefer A, et al. Food Targeting: A Real-Time PCR Assay Targeting 16S rDNA for Direct Quantification of Alicyclobacillus spp. Spores after Aptamer-Based Enrichment. J Agric Food Chem. 2015;63:4291-6 pubmed publisher
    ..evaluated by the performance requirements of the European Network of Genetically Modified Organisms Laboratories (ENGL)...
  21. Van Camp J, Hubeau M, Van den Bulcke J, VAN Acker J, Steppe K. Cambial pinning relates wood anatomy to ecophysiology in the African tropical tree Maesopsis eminii. Tree Physiol. 2017;:1-11 pubmed publisher
    ..the cambium of well-watered and drought-treated young African tropical trees of the species Maesopsis eminii Engl. we could quantify wood formation during a specific period of time and relate it to tree physiology and prevailing ..
  22. Kumari A, Papenfus H, Kulkarni M, Pošta M, van Staden J. Effect of smoke derivatives on in vitro pollen germination and pollen tube elongation of species from different plant families. Plant Biol (Stuttg). 2015;17:825-30 pubmed publisher
    ..Kniphofia uvaria Oken, Lachenalia aloides (L.f.) Engl. var. aloides and Tulbaghia simmleri P. Beauv...
  23. Schneider R. CIM Journal Club: Gene therapy for spinal muscular atrophy Comment on Mendell et al. N Engl J Med 2017;377:1713-22. Clin Invest Med. 2018;41:E31-E33 pubmed publisher
    ..Patients not only crawled, stood and walked independently, but learned to speak. These results are very encouraging for patients with SMA and offer hope for pediatric and adult patients with other types of motor neuron diseases. ..
  24. Powell P, Vitug G, Castro Silva F, Ray A. A rare case of CD1a-negative Langerhans cell histiocytosis of the central nervous system in a child. Clin Case Rep. 2017;5:1664-1667 pubmed publisher
    ..The diagnosis is supported by immunohistochemistry with the cell markers S100, CD1a, CD68, and Langerin [Blood, 126, 2015, 26 and N Engl J Med, 331, 1994, 154].
  25. Anesi G, Halpern S, Harhay M, Volpp K, Saulsgiver K. Time to selected quit date and subsequent rates of sustained smoking abstinence. J Behav Med. 2017;40:989-997 pubmed publisher
    ..in N Engl J Med 372(22):2108-2117, doi: 10...
  26. Grelewska Nowotko K, Żurawska Zajfert M, Żmijewska E, Sowa S. Optimization and Verification of Droplet Digital PCR Even-Specific Methods for the Quantification of GM Maize DAS1507 and NK603. Appl Biochem Biotechnol. 2018;185:207-220 pubmed publisher
    ..both methods have been verified according to the guidance of the European Network of GMO Laboratories (ENGL) on analytical method verification (ENGL working group on "Method Verification...
  27. Chin T, Priyesh P, Islam A. A novel approach to extraction of a large thrombus on the intraventricular guide-wire during transcatheter aortic valve replacement. Catheter Cardiovasc Interv. 2017;89:495-498 pubmed publisher
    ..N Engl J Med 2011;364:2187-2198.)...
  28. Bernstein D, Munoz F, Callahan S, Rupp R, Wootton S, Edwards K, et al. Safety and efficacy of a cytomegalovirus glycoprotein B (gB) vaccine in adolescent girls: A randomized clinical trial. Vaccine. 2016;34:313-9 pubmed publisher
    ..Although the efficacy did not reach conventional levels of significance, the results are consistent with a previous study in adult women (Pass et al. N Engl J Med 2009;360:1191) using the same formulation.
  29. Oberst A. Death in the fast lane: what's next for necroptosis?. FEBS J. 2016;283:2616-25 pubmed publisher
    ..2015) Nat Immunol 16, 689-697; Linkermann A & Green DR (2014) N Engl J Med 370, 455-465]...
  30. Barigou M, Cavalie L, Daviller B, Dubois D, Mantion B, Delobel P, et al. Isolation on Chocolate Agar Culture of Legionella pneumophila Isolates from Subcutaneous Abscesses in an Immunocompromised Patient. J Clin Microbiol. 2015;53:3683-5 pubmed publisher
    ..W. Lowry, R. J. Blankenship, W. Gridley, N. J. Troup, and L. S. Tompkins, N Engl J Med 324:109-113, 1991; M. K. Waldor, B. Wilson, and M. Swartz, Clin Infect Dis 16:51-53, 1993)...
  31. Bermúdez J, Rodríguez M, Hasegawa M, González Mujica F, Duque S, Ito Y. (6R,9S)-6"-(4"-hydroxybenzoyl)-roseoside, a new megastigmane derivative from Ouratea polyantha and its effect on hepatic glucose-6-phosphatase. Nat Prod Commun. 2012;7:973-6 pubmed
    ..2) and 4-hydroxybenzoic acid (3) were isolated and purified from leaves and stems of Ouratea polyantha Engl. Agathisflavone was isolated in a single high-speed countercurrent chromatography run, while the megastigmane was ..
  32. Lau E, Sarma A. Utility of Imaging in Risk Stratification of Chest Pain in Women. Curr Treat Options Cardiovasc Med. 2017;19:72 pubmed publisher
    ..N Engl J Med 362:886-95, 2010)...
  33. Barton K, Palmer S. How to Define the Latent Reservoir: Tools of the Trade. Curr HIV/AIDS Rep. 2016;13:77-84 pubmed publisher
    ..in PLoS Pathog 10:e1004473, 2014; Rasmussen et al. in Lancet HIV 1:e13-e21, 2014; Tebas et al. in N Engl J Med 370:901-10, 2014; Archin et al. in Nat Rev Microbiol 12:750-64, 2014; Barton et al...
  34. Lin K, Dowling S. Ultrasonography versus computed tomography for initial investigation of suspected nephrolithiasis. CJEM. 2016;18:315-8 pubmed publisher
    ..Ultrasonography versus computed tomography for suspected nephrolithiasis. N Engl J Med 2014;371(12):1100-10...
  35. Lachance Fortin A, Leblanc X, Racine S, Dupuis A, Archambault P. L'échographie équivaut-elle à la tomodensitométrie dans la prise en charge des patients avec suspicion d'urolithiase se présentant à l'urgence?. CJEM. 2016;18:402-4 pubmed publisher
    Smith-Bindman R, Aubin C, Bailitz J., et al. Ultrasonography versus Computed Tomography for Suspected Nephrolithiasis. New Engl J Med 2014;371;1100-10.
  36. Caughey A, Snowden J. Hospital variation in costs - a challenge to the value proposition. BJOG. 2017;: pubmed publisher
    ..Additionally, not only has a difference in health care utilization been demonstrated, but also health care costs.(Welch. N Engl J Med. 1993 Mar 4;328:621-7) This article is protected by copyright. All rights reserved.
  37. Botnaru T, Robert A, Mottillo S. Icatibant Compared to Steroids and Antihistamines for ACE-Inhibitor-Induced Angioedema. CJEM. 2017;19:159-162 pubmed publisher
    Article chosen Bas M, Greve J, Stelter K, et al. A Randomized Trial of Icatibant in ACE-Inhibitor-Induced Angioedema. N Engl J Med 2015;372:418-25. doi:10.1056/NEJMoa1312524.
  38. Pertuit D, Mitaine Offer A, Miyamoto T, Tanaka C, Delaude C, Lacaille Dubois M. Terpenoid glycosides from the root's barks of Eriocoelum microspermum Radlk. ex Engl. Phytochemistry. 2018;152:182-190 pubmed publisher
    ..These results represent a contribution to the chemotaxonomy of the genus Eriocoelum highlighting farnesol glycosides as chemotaxonomic markers of the subfamily of Sapindoideae in the family of Sapindaceae. ..
  39. Weiss G, Sundl M, Glasner A, Huppertz B, Moser G. The trophoblast plug during early pregnancy: a deeper insight. Histochem Cell Biol. 2016;146:749-756 pubmed publisher
    ..in Hum Reprod 25:1127-1136, 2010, Hum Reprod Oxf Engl 30:2747-2757, 2015)...
  40. Verstockt B, Ferrante M, Vermeire S, Van Assche G. New treatment options for inflammatory bowel diseases. J Gastroenterol. 2018;53:585-590 pubmed publisher
    ..in N Engl J Med 374(18):1754-1762, 2016). Oral agents inhibiting cell signaling have been explored successfully in IBD...
  41. Fujii Y, Osaki Y. Regret-sensitive treatment decisions. Health Econ Rev. 2018;8:14 pubmed publisher
    ..on whether the probability of sickness exceeds a predetermined threshold, was introduced by (Pauker and Kassirer, N Engl J Med 293:229-234, 1975) and (Pauker and Kassirer, N Engl J Med 302:1109-1116, 1980)...
  42. Mbwambo Z, Erasto P, Nondo R, Innocent E, Kidukuli A. Antibacterial and cytotoxic activities of Terminalia stenostachya and Terminalia spinosa. Tanzan J Health Res. 2011;13:119-24 pubmed
    ..The objective of this study was to investigate the biological activities of extracts of Terminalia stenostachya Engl. & Diels and Terminalia spinosa Engl...
  43. Yuwen T, Kay L. Longitudinal relaxation optimized amide 1H-CEST experiments for studying slow chemical exchange processes in fully protonated proteins. J Biomol NMR. 2017;67:295-307 pubmed publisher
    ..Yuwen, A. Sekhar and L. E. Kay, Angew Chem Int Ed Engl 2016 doi: 10.1002/anie.201610759 (Yuwen et al...
  44. Musuyu Muganza D, Fruth B, Nzunzu Lami J, Cos P, Cimanga Kanyanga R, Maes L, et al. In vitro antiprotozoal activity and cytotoxicity of extracts and fractions from the leaves, root bark and stem bark of Isolona hexaloba. J Ethnopharmacol. 2015;174:187-94 pubmed publisher
    Isolona hexaloba (Pierre) Engl. and Diels (Annonaceae) is traditionally used in D.R. Congo against parasitic diseases including malaria...
  45. Pozzatti P, Dos Reis G, Pereira D, Horst H, Espindola L, Heller M, et al. Relationship of chemical structure and anti-inflammatory activity of dihydrocorynantheol and its analogues. Pharmacol Rep. 2013;65:1263-71 pubmed
    Dihydrocorynantheol (DHC) is an alkaloid compound isolated from Esenbeckia leiocarpa Engl. that has demonstrated anti-inflammatory properties in experimental models...
  46. Ghotbeddin Z, Janahmadi M, Yadollahpour A. Study of the anti-seizure effects of low-frequency stimulation following kindling (a review of the cellular mechanism related to the anti-seizure effects of low-frequency electrical stimulation). Neurol Sci. 2017;38:19-26 pubmed publisher
    ..N Engl J Med 345(5):311-318, 2001; Yasargil et al., J Neurosurg 112(1):168-185, 2010)...
  47. Guthrie R. Canagliflozin and cardiovascular and renal events in type 2 diabetes. Postgrad Med. 2018;130:149-153 pubmed publisher
    ..Canagliflozin and cardiovascular and renal events in type 2 diabetes. N Engl J Med. 2017;377:644-657...
  48. Tchoupang E, Ateba S, Zingue S, Zehl M, Krenn L, Njamen D. Estrogenic properties of spices of the traditional Cameroonian dish "Nkui" in ovariectomized Wistar rats. J Complement Integr Med. 2016;13:151-62 pubmed publisher
    ..Capsicum frutescens Linn., Fagara leprieurii Guill. et Perr., Fagara tessmannii Engl., Mondia whitei Hook. F. Skell., Pentadiplandra brazzeana Baill., Solanum gilo Raddi., Tetrapleura tetraptera Taub...
  49. Rijsdijk M, Svensson C, Wijck A, Kalkman C, Yaksh T. Analgesic properties of intrathecal glucocorticoids in three well established preclinical pain models. Scand J Pain. 2016;10:90-102 pubmed publisher
    ..N Engl J Med 2000;23: 1514-9), the other increased pain sensations (Rijsdijk M, van Wijck AJ, Meulenhoff PC, Kavelaars A, ..
  50. Linus L, Wang S, Shi N, Hanson C, Lu Y, Alolga R, et al. The new plant Parinari kerstingii Engl.: Toxicity studies and anti-inflammatory properties. J Ethnopharmacol. 2018;220:26-34 pubmed publisher
    Parinari kerstingii Engl. extract is traditionally used for the treatment of inflammation, bronchopneumonia, feverish pains, and breast cancer...
  51. Ibrahim M, Sowemimo A, Sofidiya M, Badmos K, Fageyinbo M, Abdulkareem F, et al. Sub-acute and chronic toxicity profiles of Markhamia tomentosa ethanolic leaf extract in rats. J Ethnopharmacol. 2016;193:68-75 pubmed publisher
    Markhamia tomentosa (Benth.) K. Schum Ex Engl. (Bignoniaceae) is used in traditional African medicine for the treatment of diarrhoea, oedema, pain and malaria...
  52. Chung H, Kyung Kim W, Joo Park H, Cho L, Kim M, Kim M, et al. Anti-osteoporotic activity of harpagide by regulation of bone formation in osteoblast cell culture and ovariectomy-induced bone loss mouse models. J Ethnopharmacol. 2016;179:66-75 pubmed publisher
    Harpagide, an iridoid glucoside, is a constituent of the root of Harpagophytum procumbens var. sublobatum (Engl.) Stapf, Devil's claw which has been used in patients with osteoarthritis (OA)...
  53. Meraj P, Jauhar R, Singh A. Bare Metal Stents Versus Drug Eluting Stents: Where Do We Stand in 2015?. Curr Treat Options Cardiovasc Med. 2015;17:393 pubmed publisher
    ..N Engl J Med. 331:496, 1994; Serruys et al. N Engl J Med. 331:489, 1994; Cutlip et al. J Am Coll Cardiol 40:2082, 2002)...
  54. Nantongo J, Odoi J, Abigaba G, Gwali S. Variability of phenolic and alkaloid content in different plant parts of Carissa edulis Vahl and Zanthoxylum chalybeum Engl. BMC Res Notes. 2018;11:125 pubmed publisher
    ..However, the choice of whether to dry or freeze will depend on the specific compound of interest. Assessment of spatial variability of medicinal properties is highly recommended. ..
  55. Doggrell S, Lynch K. Is there enough evidence with evolocumab and alirocumab (antibodies to proprotein convertase substilisin-kexin type, PCSK9) on cardiovascular outcomes to use them widely? Evaluation of Sabatine MS, Giugliano RP, Wiviott SD et al. Efficacy and safety . Expert Opin Biol Ther. 2015;15:1671-5 pubmed publisher
    ..However, evolocumab and alirocumab should be used with caution in other subjects, until outcome studies in higher numbers of subjects have shown acceptable safety and cardiovascular profiles. ..
  56. Song C, Zimmerman K, Henke S, Yoder B. Inflammation and Fibrosis in Polycystic Kidney Disease. Results Probl Cell Differ. 2017;60:323-344 pubmed publisher
    ..kidney disease (PKD) is a commonly inherited disorder characterized by cyst formation and fibrosis (Wilson, N Engl J Med 350:151-164, 2004) and is caused by mutations in cilia or cilia-related proteins, such as polycystin 1 or 2 (..
  57. Mendes D, Alves C, Afonso N, Cardoso F, Passos Coelho J, Costa L, et al. The benefit of HER2-targeted therapies on overall survival of patients with metastatic HER2-positive breast cancer--a systematic review. Breast Cancer Res. 2015;17:140 pubmed publisher
    ..OS improved from 20.3 months in the first RCT (standard chemotherapy; Slamon et al. (N Engl J Med 344:783-92, 2001)) evaluating HER2-targeting therapies to 48 months in the study of Swain et al...
  58. Harrison P, Sanz D, Hollywood J. Impact of gene editing on the study of cystic fibrosis. Hum Genet. 2016;135:983-92 pubmed publisher
    ..However, despite two licensed drugs (Ramsey et al. N Engl J Med 365(18):1663-1672, 2011; Wainwright et al...
  59. Ebersbach J, Schnitzler J, Favre A, Muellner Riehl A. Evolutionary radiations in the species-rich mountain genus Saxifraga L. BMC Evol Biol. 2017;17:119 pubmed publisher
    ..Ciliatae Haworth subsect. Hirculoideae Engl. & Irmsch. and sect. Porphyrion Tausch subsect. Kabschia Engl...
  60. Hu Z, Whitney D, Anderson J, Cao M, Ho C, Choi Y, et al. Analytical performance of a bronchial genomic classifier. BMC Cancer. 2016;16:161 pubmed publisher
    ..of lung nodules and lesions that are inconclusive by bronchoscopy, using bronchial brushing specimens (N Engl J Med 373:243-51, 2015, BMC Med Genomics 8:18, 2015)...
  61. Santos C, Masullo M, Cerulli A, Mari A, Estevam C, Pizza C, et al. Isolation of antioxidant phenolics from Schinopsis brasiliensis based on a preliminary LC-MS profiling. Phytochemistry. 2017;140:45-51 pubmed publisher
    The phenolic content of the ethanol extract of the stem bark of the Brazilian plant Schinopsis brasiliensis Engl. (Anacardiaceae) has been evaluated together with the antioxidant activity...
  62. Tigchelaar W, de Jong A, van Gilst W, de Boer R, Silljé H. In EXOG-depleted cardiomyocytes cell death is marked by a decreased mitochondrial reserve capacity of the electron transport chain. Bioessays. 2016;38 Suppl 1:S136-45 pubmed publisher
    Depletion of mitochondrial endo/exonuclease G-like (EXOG) in cultured neonatal cardiomyocytes stimulates mitochondrial oxygen consumption rate (OCR) and induces hypertrophy via reactive oxygen species (ROS)...
  63. Juhasz B, Johnson R, Brewer J. An Investigation into the Processing of Lexicalized English Blend Words: Evidence from Lexical Decisions and Eye Movements During Reading. J Psycholinguist Res. 2017;46:281-294 pubmed publisher
    New words enter the language through several word formation processes [see Simonini (Engl J 55:752-757, 1966)]. One such process, blending, occurs when two source words are combined to represent a new concept (e.g...
  64. Ljaljević Grbić M, Unković N, Dimkić I, Janaćković P, Gavrilović M, Stanojević O, et al. Frankincense and myrrh essential oils and burn incense fume against micro-inhabitants of sacral ambients. Wisdom of the ancients?. J Ethnopharmacol. 2018;219:1-14 pubmed publisher
    Essential oils obtained from resins of Boswellia carteri Birdw. and Commiphora myrrha (Nees) Engl., commonly known as frankincense and true myrrh respectively, have been used extensively since 2800 BCE for the treatment of skin sores, ..
  65. Mireku E, Kusari S, Eckelmann D, Mensah A, Talontsi F, Spiteller M. Anti-inflammatory tirucallane triterpenoids from Anopyxis klaineana Pierre (Engl.), (Rhizophoraceae). Fitoterapia. 2015;106:84-91 pubmed publisher
    ..Furthermore, compounds 1 and 7 exhibited remarkable anti-inflammatory potential in a prostaglandin E2 (PGE2) competitive enzyme immunoassay with IC50 values of 3.63 μM and 10.23 μM, respectively. ..
  66. Shen C, Yang L, Jiang J, Zheng C, Zhu W. Immune enhancement effects and extraction optimization of polysaccharides from Citrus aurantium L. var. amara Engl. Food Funct. 2017;8:796-807 pubmed publisher
    The crude polysaccharides of Citrus aurantium L. var. amara Engl (CAVAPs) were extracted and their bioactivities including DPPH radical scavenging activity, cytotoxicity to human breast cancer cells, MCF-7, as well as lung cancer cells, ..
  67. Bigan E, Mattelaer H, Herdewijn P. Theoretical Analysis of a Self-Replicator With Reduced Template Inhibition Based on an Informational Leaving Group. J Mol Evol. 2016;82:93-109 pubmed publisher
    The first non-enzymatic self-replicating systems, as proposed by von Kiedrowski (Angew Chem Int Ed Engl 25(10):932-935, 1986) and Orgel (Nature 327(6120):346-347, 1987), gave rise to the analytical background still used today to describe ..
  68. Adongo D, Mante P, Kukuia K, Biney R, Boakye Gyasi E, Benneh C, et al. Anticonvulsant activity of Pseudospondias microcarpa (A. Rich) Engl. hydroethanolic leaf extract in mice: The role of excitatory/inhibitory neurotransmission and nitric oxide pathway. J Ethnopharmacol. 2017;206:78-91 pubmed publisher
    Pseudospondias microcarpa (A. Rich) Engl. is a plant used for managing various diseases including central nervous system disorders. This study explored the anticonvulsant activity of P...
  69. Balasubramaniam S, Lewis B, Greed L, Meili D, Flier A, Yamamoto R, et al. Heterozygous Monocarboxylate Transporter 1 (MCT1, SLC16A1) Deficiency as a Cause of Recurrent Ketoacidosis. JIMD Rep. 2016;29:33-38 pubmed
    ..N Engl J Med, 371:1900-1907, 2014) as a cause for recurrent ketoacidoses...
  70. Chandrasekaran P, Dezfulian C, Polderman K. What is the right temperature to cool post-cardiac arrest patients?. Crit Care. 2015;19:406 pubmed publisher
    ..Targeted temperature management at 33 °C versus 36 °C after cardiac arrest. N Engl J Med. 2013;369:2197-206. doi: 10.1056/NEJMoa1310519 . Epub 2013 Nov 17. Pub Med PMID: 20089970...
  71. Dranitsaris G, Shane L, Galanaud J, Stemer G, Debourdeau P, Woodruff S. Dalteparin or vitamin K antagonists to prevent recurrent venous thromboembolism in cancer patients: a patient-level economic analysis for France and Austria. Support Care Cancer. 2017;25:2093-2102 pubmed publisher
    ..Agent selection is guided in part by one large randomized trial (i.e., CLOT; Lee et al., N Engl J Med 349:146-53, 2003) which demonstrated that dalteparin reduced the relative risk of recurrence by 52% compared ..
  72. Soler D, Young A, Cooper K, Kerstetter Fogle A, Barnholtz Sloan J, Gittleman H, et al. The ratio of HLA-DR and VNN2+ expression on CD14+ myeloid derived suppressor cells can distinguish glioblastoma from radiation necrosis patients. J Neurooncol. 2017;134:189-196 pubmed publisher
    ..N Engl J Med 352:987-996, 2005)...
  73. Shen C, Jiang J, Zhu W, Ou Yang Q. Anti-inflammatory Effect of Essential Oil from Citrus aurantium L. var. amara Engl. J Agric Food Chem. 2017;65:8586-8594 pubmed publisher
    ..The bioactivities of essential oil from blossoms of Citrus aurantium L. var. amara Engl (CAVAO) showed greater anti-inflammation potential than that of antioxidant, anticancer, and 3T3-L1 proliferation ..
  74. Duchardt Ferner E, Wöhnert J. NMR experiments for the rapid identification of P=O···H-X type hydrogen bonds in nucleic acids. J Biomol NMR. 2017;69:101-110 pubmed publisher
    ..Angew Chem Int Ed Engl 50:7927-7930, 2011)...
  75. Lackovic Z. "Bunanje": XX Century Abuse of Atropa Belladonna Halucinogenic Berries in Continental Croatia. Psychiatr Danub. 2017;29:379-382 pubmed publisher
    Atropa belladonna (Engl. deadly nightshade, Cro. velebilje, bunika) is a plant containing pharmacologically active, potentially toxic alkaloids: atropine, hyocyamine and scopolamine...
  76. Arenas E, Trinidad T. Acute effects of thermally processed pili (Canarium ovatum, Engl.) pomace drink on plasma antioxidant and polyphenol status in humans. Avicenna J Phytomed. 2017;7:467-476 pubmed
    Pili (Canarium ovatum, Engl.) pomace is an underutilized agricultural waste that possesses great potential to be regarded as a functional food ingredient...
  77. Steinig J, Bazan A, Happe S, Antonetti S, Shevrin H. Processing of a Subliminal Rebus during Sleep: Idiosyncratic Primary versus Secondary Process Associations upon Awakening from REM- versus Non-REM-Sleep. Front Psychol. 2017;8:1955 pubmed publisher
    ..of a comb (German: "Kamm") and an image of a raft (German: "Floß"), resulting in the German rebus word "kampflos" (Engl.: without a struggle), was flashed subliminally (at 1 ms) to 20 participants before going to sleep...
  78. Hilman B, Angert A. Measuring the ratio of CO2 efflux to O2 influx in tree stem respiration. Tree Physiol. 2016;36:1422-1431 pubmed
    ..We tested the performance of the Hampadah with samples from 36 trees (Tetragastris panamensis (Engl.) Kuntze)...
  79. Verweij N, Mateo Leach I, van den Boogaard M, van Veldhuisen D, Christoffels V, Hillege H, et al. Genetic determinants of P wave duration and PR segment. Circ Cardiovasc Genet. 2014;7:475-81 pubmed publisher
    ..Through genome-wide association we also identified genetic variants specifically associated with P wave duration which might be relevant for cardiac biology. ..
  80. Young M, Inglessis I. Transcatheter Aortic Valve Replacement: Outcomes, Indications, Complications, and Innovations. Curr Treat Options Cardiovasc Med. 2017;19:81 pubmed publisher
    ..N Engl J Med. 374:1609-1620 2016; Reardon et al. N Engl J Med. 376:1321-1331 2017)...
  81. Hong K, Lim J, Kim J, Tabara Y, Ueshima H, Miki T, et al. Identification of three novel genetic variations associated with electrocardiographic traits (QRS duration and PR interval) in East Asians. Hum Mol Genet. 2014;23:6659-67 pubmed publisher
    ..In addition, C allele of rs17026156 increases PR interval (beta ± SE, 2.39 ± 0.40 ms) and exists far more frequently in East Asians (0.46) than in Europeans and Africans (0.05 and 0.08, respectively). ..
  82. Moreira G, Eltz R, Pase R, Silva G, Bordignon S, Mey W, et al. Cecidonius pampeanus, gen. et sp. n.: an overlooked and rare, new gall-inducing micromoth associated with Schinus in southern Brazil (Lepidoptera, Cecidosidae). Zookeys. 2017;:37-74 pubmed publisher
    ..It induces unnoticed, small galls under swollen stems of Schinus weinmannifolius Mart. ex Engl. (Anacardiaceae)...
  83. Wieszczy P, Regula J, Kaminski M. Adenoma detection rate and risk of colorectal cancer. Best Pract Res Clin Gastroenterol. 2017;31:441-446 pubmed publisher
    ..We revised three studies (Kaminski et al., N Engl J Med 2010; Corley et al., N Engl J Med 2014 and Rogal et al...
  84. Hickey M, Considine R, Israel R, Mahar T, McCammon M, Tyndall G, et al. Leptin is related to body fat content in male distance runners. Am J Physiol. 1996;271:E938-40 pubmed
    Leptin, the product of the ob gene, has been reported to be related to body fat in humans (Considine et al. N. Engl. J. Med. 334: 292, 1996). However, little is known about the physiology of this putative satiety signal in humans...
  85. Sullivan K, Bassiri H, Bousfiha A, Costa Carvalho B, Freeman A, Hagin D, et al. Emerging Infections and Pertinent Infections Related to Travel for Patients with Primary Immunodeficiencies. J Clin Immunol. 2017;37:650-692 pubmed publisher
    ..common causes of fever in travelers provides important information for the general population Thwaites and Day (N Engl J Med 376:548-560, 2017)...
  86. Duguay B, Smiley J. Mitochondrial nucleases ENDOG and EXOG participate in mitochondrial DNA depletion initiated by herpes simplex virus 1 UL12.5. J Virol. 2013;87:11787-97 pubmed publisher
    ..5. We provide evidence that the mitochondrial nucleases endonuclease G (ENDOG) and endonuclease G-like 1 (EXOG) play key redundant roles in UL12.5-mediated mtDNA depletion. Overall, our data indicate that UL12...
  87. Szczesny B, Brunyánszki A, Olah G, Mitra S, Szabo C. Opposing roles of mitochondrial and nuclear PARP1 in the regulation of mitochondrial and nuclear DNA integrity: implications for the regulation of mitochondrial function. Nucleic Acids Res. 2014;42:13161-73 pubmed publisher
    ..PARP1 interacts with a key mitochondrial-specific DNA base excision repair (BER) enzymes, namely EXOG and DNA polymerase gamma (Polγ), which under oxidative stress become poly(ADP-ribose)lated (PARylated)...
  88. de Lima Saraiva S, Oliveira F, Júnior R, Araújo C, de Oliveira A, Pacheco A, et al. Chemical Analysis and Evaluation of Antioxidant, Antimicrobial, and Photoprotective Activities of Schinopsis brasiliensis Engl. (Anacardiaceae). ScientificWorldJournal. 2017;2017:1713921 pubmed publisher
    i>Schinopsis brasiliensis Engl. is a native plant of Caatinga which has high concentrations of compounds capable of absorbing ultraviolet light, suggesting its potential application for the development of sunscreen preparations...