EXOC7

Summary

Gene Symbol: EXOC7
Description: exocyst complex component 7
Alias: 2-5-3p, BLOM4, EX070, EXO70, EXOC1, Exo70p, YJL085W, exocyst complex component 7, exocyst complex component Exo70
Species: human
Products:     EXOC7

Top Publications

  1. Dellago H, Löscher M, Ajuh P, Ryder U, Kaisermayer C, Grillari Voglauer R, et al. Exo70, a subunit of the exocyst complex, interacts with SNEV(hPrp19/hPso4) and is involved in pre-mRNA splicing. Biochem J. 2011;438:81-91 pubmed publisher
    ..In the present paper we report that Exo70 interacts directly with SNEV(hPrp19/hPso4) and shuttles to the nucleus, where it associates with the spliceosome...
  2. Xiong X, Xu Q, Huang Y, Singh R, Anderson R, Leof E, et al. An association between type I? PI4P 5-kinase and Exo70 directs E-cadherin clustering and epithelial polarization. Mol Biol Cell. 2012;23:87-98 pubmed publisher
    ..I? phosphatidylinositol-4-phosphate 5-kinase (PIPKI?) associates with the exocyst via a direct interaction with Exo70, the exocyst subunit that guides the polarized targeting of exocyst to the plasma membrane...
  3. Inoue M, Chang L, Hwang J, Chiang S, Saltiel A. The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin. Nature. 2003;422:629-33 pubmed
    ..Here we show that TC10 interacts with one of the components of the exocyst complex, Exo70. Exo70 translocates to the plasma membrane in response to insulin through the activation of TC10, where it ..
  4. Zuo X, Zhang J, Zhang Y, Hsu S, Zhou D, Guo W. Exo70 interacts with the Arp2/3 complex and regulates cell migration. Nat Cell Biol. 2006;8:1383-8 pubmed
    ..Here, we report that the exocyst component Exo70 interacts with the Arp2/3 complex, a key regulator of actin polymerization...
  5. Gorski M, Lecchi A, Femia E, La Marca S, Cairo A, Pappalardo E, et al. Complications of whole-exome sequencing for causal gene discovery in primary platelet secretion defects. Haematologica. 2019;: pubmed publisher
    ..Platelet candidate gene analysis revealed gene defects in 10/14 patients, which included ADRA2A, ARHGAP1, DIAPH1, EXOC1, FCGR2A, ITPR1, LTBP1, PTPN7, PTPN12, PRKACG, PRKCD, RAP1GAP, STXBP5L, and VWF...
  6. Tay Y, Leda M, Spanos C, Rappsilber J, Goryachev A, Sawin K. Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex. Cell Rep. 2019;26:1654-1667.e7 pubmed publisher
    ..We further find that Orb6 phosphorylation of Sec3 contributes to exocyst function in concert with exocyst protein Exo70. We propose that Orb6 contributes to polarized growth by regulating membrane trafficking at multiple levels.
  7. Zhao J, Zhang X, Wan W, Zhang H, Liu J, Li M, et al. Identification and Characterization of the EXO70 Gene Family in Polyploid Wheat and Related Species. Int J Mol Sci. 2018;20: pubmed publisher
    The EXO70 gene family is involved in different biological processes in plants, ranging from plant polar growth to plant immunity. To date, analysis of the EXO70 gene family has been limited in Triticeae species, e.g...
  8. Bhalla M, Van Ngo H, Gyanwali G, Ireton K. The Host Scaffolding Protein Filamin A and the Exocyst Complex Control Exocytosis during InlB-Mediated Entry of Listeria monocytogenes. Infect Immun. 2019;87: pubmed publisher
    ..Depletion of PKC-α, mTOR, RalA, or FlnA impaired recruitment of the exocyst component Exo70 to sites of InlB-mediated entry...
  9. Lira M, Arancibia D, Orrego P, Montenegro Venegas C, Cruz Y, Garcia J, et al. The Exocyst Component Exo70 Modulates Dendrite Arbor Formation, Synapse Density, and Spine Maturation in Primary Hippocampal Neurons. Mol Neurobiol. 2018;: pubmed publisher
    ..Synaptogenesis is augmented by the secretion of factors, like BDNF, Reelin, BMPs, or Wnts. Exo70 is a component of the exocyst complex, a protein complex that guides membrane addition and polarized exocytosis...

More Information

Publications71

  1. Katoh Y, Nozaki S, Hartanto D, Miyano R, Nakayama K. Architectures of multisubunit complexes revealed by a visible immunoprecipitation assay using fluorescent fusion proteins. J Cell Sci. 2015;128:2351-62 pubmed publisher
    ..subunits from multisubunit interaction assays, we unequivocally demonstrated one-to-many subunit interactions (Exo70 with Sec10+Sec15, and Exo84 with Sec10+Sec15+Exo70)...
  2. Balakrishnan A, Guruprasad K, Satyamoorthy K, Joshi M. Interleukin-6 determines protein stabilization of DNA methyltransferases and alters DNA promoter methylation of genes associated with insulin signaling and angiogenesis. Lab Invest. 2018;98:1143-1158 pubmed publisher
    ..DNA methylation status of genes associated with insulin signaling and angiogenesis such as RPS6KA2, PIK3R2, FOXD3, EXOC7, MAP3K8, ITPKB, EPHA6, IGF1R, and FOXC2 were validated by bisulfite DNA sequencing...
  3. Huang L, Zhang C. Use Endosidin2 to Study Plant Exocytosis and Vacuolar Trafficking. Methods Mol Biol. 2018;1789:167-175 pubmed publisher
    ..Small molecule Endosidin2 (ES2) has been found to target Exo70 protein and inhibit exocytosis and promote vacuolar trafficking in plants...
  4. Koon A, Chen Z, Peng S, Fung J, Zhang X, Lembke K, et al. Drosophila Exo70 Is Essential for Neurite Extension and Survival under Thermal Stress. J Neurosci. 2018;38:8071-8086 pubmed publisher
    ..b>Exo70 is a conserved component of the exocyst whose function in Drosophila is unclear...
  5. Liu D, Novick P. Bem1p contributes to secretory pathway polarization through a direct interaction with Exo70p. J Cell Biol. 2014;207:59-72 pubmed publisher
    ..are brought to these sites by riding on secretory vesicles as they are actively transported along actin cables, Exo70p displays actin-independent localization to these sites, implying an interaction with a polarity determinant...
  6. Georgilis A, Klotz S, Hanley C, Herranz N, Weirich B, Morancho B, et al. PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells. Cancer Cell. 2018;34:85-102.e9 pubmed publisher
    ..PTBP1 regulates the alternative splicing of genes involved in intracellular trafficking, such as EXOC7, to control the SASP...
  7. Hutagalung A, Coleman J, Pypaert M, Novick P. An internal domain of Exo70p is required for actin-independent localization and mediates assembly of specific exocyst components. Mol Biol Cell. 2009;20:153-63 pubmed publisher
    ..Two subunits, Sec3p and Exo70p, localize to exocytic sites by an actin-independent pathway, whereas the other six ride on vesicles along actin ..
  8. Lee M, Lin Y, Deng Y, Hsu W, Shen C, Cheng Y, et al. Modulation of alternative splicing by expression of small nuclear ribonucleoprotein polypeptide N. FEBS J. 2014;281:5194-207 pubmed publisher
    ..found that the inclusion frequencies of alternatively spliced exons in the bridging integrator 1 and exocyst complex component 7 (EXOC7) genes were modulated by SmN expression...
  9. Martin T. PI(4,5)Pâ‚‚-binding effector proteins for vesicle exocytosis. Biochim Biophys Acta. 2015;1851:785-93 pubmed publisher
    ..vesicle fusion mediated in part by the PI(4,5)Pâ‚‚-binding subunits of the exocyst complex (Sec3, Exo70)...
  10. Chi Y, Yang Y, Li G, Wang F, Fan B, Chen Z. Identification and characterization of a novel group of legume-specific, Golgi apparatus-localized WRKY and Exo70 proteins from soybean. J Exp Bot. 2015;66:3055-70 pubmed publisher
    ..Here we report the characterization of a group of proteins evolved from WRKY and exocyst complex subunit Exo70 proteins through fusion with a novel transmembrane (TM) domain in soybean (Glycine max)...
  11. Park S, Jeong J, Park Y, Park K, Lee H, Lee N, et al. Disrupted-in-schizophrenia-1 (DISC1) Regulates Endoplasmic Reticulum Calcium Dynamics. Sci Rep. 2015;5:8694 pubmed publisher
    ..Here, we showed that DISC1 localizes to the outer surface of the endoplasmic reticulum (ER). EXOC1, a subunit of the exocyst complex, interacted with DISC1 and affected its recruitment to inositol-1,4,5-..
  12. Fernandes M, Corrotte M, Miguel D, Tam C, Andrews N. The exocyst is required for trypanosome invasion and the repair of mechanical plasma membrane wounds. J Cell Sci. 2015;128:27-32 pubmed publisher
    ..Here, we show that Exo70 and Sec8 (also known as EXOC7 and EXOC4, respectively), components of the exocyst complex, accumulate in nascent T...
  13. Oztan A, Silvis M, Weisz O, Bradbury N, Hsu S, Goldenring J, et al. Exocyst requirement for endocytic traffic directed toward the apical and basolateral poles of polarized MDCK cells. Mol Biol Cell. 2007;18:3978-92 pubmed
    ..We observed that the exocyst subunits Sec6, Sec8, and Exo70 were localized to early endosomes, transferrin-positive common recycling endosomes, and Rab11a-positive apical ..
  14. Wang Z, Li P, Yang Y, Chi Y, Fan B, Chen Z. Expression and Functional Analysis of a Novel Group of Legume-specific WRKY and Exo70 Protein Variants from Soybean. Sci Rep. 2016;6:32090 pubmed publisher
    ..Recently, we have reported a novel WRKY-related protein (GmWRP1) and a new clade of Exo70 proteins (GmExo70J) from soybean with homologs found only in legumes...
  15. Pleskot R, Cwiklik L, Jungwirth P, Žárský V, Potocký M. Membrane targeting of the yeast exocyst complex. Biochim Biophys Acta. 2015;1848:1481-9 pubmed publisher
    ..molecular dynamics simulations to elucidate structural details of the interaction of yeast Sec3p and Exo70p with lipid bilayers containing PIP2...
  16. Pérez P, Portales E, Santos B. Rho4 interaction with exocyst and septins regulates cell separation in fission yeast. Microbiology. 2015;161:948-59 pubmed publisher
    ..Moreover, pull-down experiments demonstrate that Rho4 can interact with exocyst subunits, such as Sec8 and Exo70, and septin proteins, such as Spn3...
  17. Wu H, Turner C, Gardner J, Temple B, Brennwald P. The Exo70 subunit of the exocyst is an effector for both Cdc42 and Rho3 function in polarized exocytosis. Mol Biol Cell. 2010;21:430-42 pubmed publisher
    ..Here, we present evidence that the Exo70 component of the exocyst complex is a direct effector of both Rho3 and Cdc42...
  18. Kulich I, Vojtíková Z, Sabol P, Ortmannová J, Nedela V, Tihlaříková E, et al. Exocyst Subunit EXO70H4 Has a Specific Role in Callose Synthase Secretion and Silica Accumulation. Plant Physiol. 2018;176:2040-2051 pubmed publisher
    ..To address the specificity of EXO70H4 among the EXO70 family, we complemented the exo70H4-1 mutant by 18 different Arabidopsis (Arabidopsis thaliana) ..
  19. Hong D, Jeon B, Kim S, Hwang J, Lee Y. The ROP2-RIC7 pathway negatively regulates light-induced stomatal opening by inhibiting exocyst subunit Exo70B1 in Arabidopsis. New Phytol. 2016;209:624-35 pubmed publisher
    ..RIC7 interacted with exocyst subunit Exo70 family protein B1 (Exo70B1), a component of the vesicle trafficking machinery...
  20. Lesigang J, Dong G. Analysis of Three-Dimensional Structures of Exocyst Components. Methods Mol Biol. 2016;1369:191-204 pubmed publisher
    ..This chapter briefly describes the protocols used in our structure determination of Exo70p and Exo84p, two subunits of the exocyst from Saccharomyces cerevisiae...
  21. Liu D, Li X, Shen D, Novick P. Two subunits of the exocyst, Sec3p and Exo70p, can function exclusively on the plasma membrane. Mol Biol Cell. 2018;29:736-750 pubmed publisher
    ..Only N-terminally anchored TM-Sec3p and C-terminally anchored Exo70p-TM proved functional...
  22. Kumar K, Srivastava V, Purayannur S, Kaladhar V, Cheruvu P, Verma P. WRKY domain-encoding genes of a crop legume chickpea (Cicer arietinum): comparative analysis with Medicago truncatula WRKY family and characterization of group-III gene(s). DNA Res. 2016;23:225-39 pubmed publisher
    ..in galegoid legumes, CaWRKY16 and its orthologues encode for a novel protein having a transmembrane and partial Exo70 domains flanking a group-III WD...
  23. Seixas C, Choi S, Polgar N, Umberger N, East M, Zuo X, et al. Arl13b and the exocyst interact synergistically in ciliogenesis. Mol Biol Cell. 2016;27:308-20 pubmed publisher
    ..Nevertheless, the precise role of Arl13b remains elusive. Here we report that the exocyst subunits Sec8, Exo70, and Sec5 bind preferentially to the GTP-bound form of Arl13b, consistent with the exocyst being an effector of ..
  24. Chen J, Yamagata A, Kubota K, Sato Y, Goto Ito S, Fukai S. Crystal structure of Sec10, a subunit of the exocyst complex. Sci Rep. 2017;7:40909 pubmed publisher
    The exocyst complex is a heterooctameric protein complex composed of Sec3, Sec5, Sec6, Sec8, Sec10, Sec15, Exo70 and Exo84...
  25. Synek L, Vukašinović N, Kulich I, Hála M, Aldorfová K, Fendrych M, et al. EXO70C2 Is a Key Regulatory Factor for Optimal Tip Growth of Pollen. Plant Physiol. 2017;174:223-240 pubmed publisher
    ..In land plants, several exocyst subunits are encoded by double or triple paralogs, culminating in tens of EXO70 paralogs. Out of 23 Arabidopsis thaliana EXO70 isoforms, we analyzed seven isoforms expressed in pollen...
  26. Gupta Y, Dagdas Y, Martínez Rocha A, Kershaw M, Littlejohn G, Ryder L, et al. Septin-Dependent Assembly of the Exocyst Is Essential for Plant Infection by Magnaporthe oryzae. Plant Cell. 2015;27:3277-89 pubmed publisher
    ..The exocyst components Sec3, Sec5, Sec6, Sec8, and Sec15, and exocyst complex proteins Exo70 and Exo84 localize specifically in a ring formation at the appressorium pore...
  27. Ma W, Wang Y, Yao X, Xu Z, An L, Yin M. The role of Exo70 in vascular smooth muscle cell migration. Cell Mol Biol Lett. 2016;21:20 pubmed publisher
    As a key subunit of the exocyst complex, Exo70 has highly conserved sequence and is widely found in yeast, mammals, and plants...
  28. Sekeres J, Pejchar P, Santrucek J, Vukašinović N, Zarsky V, Potocky M. Analysis of Exocyst Subunit EXO70 Family Reveals Distinct Membrane Polar Domains in Tobacco Pollen Tubes. Plant Physiol. 2017;173:1659-1675 pubmed publisher
    The vesicle-tethering complex exocyst is one of the crucial cell polarity regulators. The EXO70 subunit is required for the targeting of the complex and is represented by many isoforms in angiosperm plant cells...
  29. Zhang C, Brown M, van de Ven W, Zhang Z, Wu B, Young M, et al. Endosidin2 targets conserved exocyst complex subunit EXO70 to inhibit exocytosis. Proc Natl Acad Sci U S A. 2016;113:E41-50 pubmed publisher
    ..We discovered that the small molecule Endosidin2 (ES2) binds to the EXO70 (exocyst component of 70 kDa) subunit of the exocyst complex, resulting in inhibition of exocytosis and endosomal ..
  30. Xiao L, Zheng K, Lv X, Hou J, Xu L, Zhao Y, et al. Exo70 is an independent prognostic factor in colon cancer. Sci Rep. 2017;7:5039 pubmed publisher
    b>Exo70, a key component of the Exocyst complex, plays important roles in human cancer progression beyond exocytosis...
  31. Tu B, Hu L, Chen W, Li T, Hu B, Zheng L, et al. Disruption of OsEXO70A1 Causes Irregular Vascular Bundles and Perturbs Mineral Nutrient Assimilation in Rice. Sci Rep. 2015;5:18609 pubmed publisher
    ..Expression analysis revealed that mutations in rls2 triggers transcriptional fluctuation of orthologous EXO70 genes and affects genes involved in primary nutrient absorption and transport...
  32. Nelms B, Dalomba N, Lencer W. A targeted RNAi screen identifies factors affecting diverse stages of receptor-mediated transcytosis. J Cell Biol. 2017;216:511-525 pubmed publisher
    ..Pulse-chase kinetic transport assays on four of the top-ranking genes (EXOC2, EXOC7, PARD6B, and LEPROT) revealed distinct effects on the apical and basolateral recycling and transcytotic pathways, ..
  33. Pedersen G, Jensen H, Schelde A, Toft C, Pedersen H, Ulrichsen M, et al. The basolateral vesicle sorting machinery and basolateral proteins are recruited to the site of enteropathogenic E. coli microcolony growth at the apical membrane. PLoS ONE. 2017;12:e0179122 pubmed publisher
    ..Components of the basolateral vesicle targeting machinery were re-routed. The Exocyst (Exo70) was recruited to individual EPEC as was the basolateral vesicle SNARE VAMP-3...
  34. Lee B, Baek J, Min H, Bae S, Moon K, Kim M, et al. Exocyst Complex Member EXOC5 Is Required for Survival of Hair Cells and Spiral Ganglion Neurons and Maintenance of Hearing. Mol Neurobiol. 2018;55:6518-6532 pubmed publisher
    The exocyst, an octameric protein complex consisting of Exoc1 through Exoc8, was first determined to regulate exocytosis by targeting vesicles to the plasma membrane in yeast to mice...
  35. Ahmed S, Macara I. The Par3 polarity protein is an exocyst receptor essential for mammary cell survival. Nat Commun. 2017;8:14867 pubmed publisher
    ..A small region of PAR3 binds directly to Exo70 and is sufficient for exocyst docking, membrane-protein delivery and cell survival...
  36. Mizuno S, Takami K, Daitoku Y, Tanimoto Y, Dinh T, Mizuno Iijima S, et al. Peri-implantation lethality in mice carrying megabase-scale deletion on 5qc3.3 is caused by Exoc1 null mutation. Sci Rep. 2015;5:13632 pubmed publisher
    ..2-Mb genomic region containing nine genes (Kit, Kdr, Srd5a3, Tmeme165, Clock, Pdcl2, Nmu, Exoc1, and Cep135). We designated this mutant allele Kit(WS)...
  37. Wu X, Zhang Q, Xu S, Jin P, Luan P, Li Y, et al. Differential expression of six chicken genes associated with fatness traits in a divergently selected broiler population. Mol Cell Probes. 2016;30:1-5 pubmed publisher
    ..suppressor candidate 3 (TUSC3), phosphoribosyl pyrophosphate amidotransferase (PPAT), exocyst complex component 1 (EXOC1), v-myb myeloblastosis viral oncogene homolog (avian)-like 2 (MYBL2) and KIAA1211 (undefined) genes...
  38. Fielding A, Schonteich E, Matheson J, Wilson G, Yu X, Hickson G, et al. Rab11-FIP3 and FIP4 interact with Arf6 and the exocyst to control membrane traffic in cytokinesis. EMBO J. 2005;24:3389-99 pubmed
    ..b>Exo70p, a component of the Exocyst complex, also localises to the furrow of dividing cells and interacts with Arf6...
  39. Sans N, Prybylowski K, Petralia R, Chang K, Wang Y, Racca C, et al. NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex. Nat Cell Biol. 2003;5:520-30 pubmed
    ..Furthermore, they suggest that an exocyst-SAP102-NMDAR complex is an important component of NMDAR trafficking. ..
  40. Wang S, Liu Y, Adamson C, Valdez G, Guo W, Hsu S. The mammalian exocyst, a complex required for exocytosis, inhibits tubulin polymerization. J Biol Chem. 2004;279:35958-66 pubmed
    ..Deletion of exocyst subunit sec5, sec6, sec15, or exo70 diminished its tubulin polymerization inhibition activity...
  41. Xu K, Shen X, Li H, Pacheco Rodriguez G, Moss J, Vaughan M. Interaction of BIG2, a brefeldin A-inhibited guanine nucleotide-exchange protein, with exocyst protein Exo70. Proc Natl Acad Sci U S A. 2005;102:2784-9 pubmed
    ..Clone p2-5-3, encoding a form of human exocyst protein Exo70, interacted with BIG2 amino acids 1-643 and 1-832, but not 644-832, which was confirmed by coimmunoprecipitation ..
  42. Chen Z, Lin X, Zhang Z, Huang J, Fu S, Huang R. EXO70 protein influences dengue virus secretion. Microbes Infect. 2011;13:143-50 pubmed publisher
    ..This study identified that EXO70 protein, a member of the exocyst complex influenced DENV infection...
  43. Hertzog M, Monteiro P, Le Dez G, Chavrier P. Exo70 subunit of the exocyst complex is involved in adhesion-dependent trafficking of caveolin-1. PLoS ONE. 2012;7:e52627 pubmed publisher
    ..Using total internal reflection fluorescent microscopy (TIRF-M), we observe that the exocyst subunit Exo70 forms punctuate structures at the plasma membrane and partially localizes with caveolin-1, the main component of ..
  44. Zhang X, Pumplin N, Ivanov S, Harrison M. EXO70I Is Required for Development of a Sub-domain of the Periarbuscular Membrane during Arbuscular Mycorrhizal Symbiosis. Curr Biol. 2015;25:2189-95 pubmed publisher
    ..The EXOCYST complex is central to this process, and in yeast, regulation of the EXO70 subunit influences exocytosis and cargo specificity...
  45. Tanaka T, Goto K, Iino M. Sec8 modulates TGF-? induced EMT by controlling N-cadherin via regulation of Smad3/4. Cell Signal. 2017;29:115-126 pubmed publisher
    ..of the subunits of the exocyst, which is an evolutionarily conserved complex of eight proteins, comprising Sec3 (EXOC1), Sec5 (EXOC2), Sec6 (EXOC3), Sec8 (EXOC4), Sec10 (EXOC5), Sec15 (EXOC6), Exo70 (EXOC7), and Exo84 (EXOC8) ..
  46. Moskalenko S, Tong C, Rosse C, Mirey G, Formstecher E, Daviet L, et al. Ral GTPases regulate exocyst assembly through dual subunit interactions. J Biol Chem. 2003;278:51743-8 pubmed
  47. Zhao G, Zhang H, Huang Z, Lv L, Yan F. Cortactin and Exo70 mediated invasion of hepatoma carcinoma cells by MMP-9 secretion. Mol Biol Rep. 2016;43:407-14 pubmed publisher
    ..the regulation mechanism of cortactin (CTTN) on matrix metalloproteinases 9 (MMP-9) and its relations with Exo70 in invasion of hepatoma carcinoma (HCC) cells...
  48. Oeffner F, Moch C, Neundorf A, Hofmann J, Koch M, Grzeschik K. Novel interaction partners of Bardet-Biedl syndrome proteins. Cell Motil Cytoskeleton. 2008;65:143-55 pubmed
    ..analyses (ALDOB, EPAS1) and substantiated by colocalization studies at the subcellular level (ALDOB, EXOC7, FLOT1, KRT18, PAX2)...
  49. Bodemann B, Orvedahl A, Cheng T, Ram R, Ou Y, Formstecher E, et al. RalB and the exocyst mediate the cellular starvation response by direct activation of autophagosome assembly. Cell. 2011;144:253-67 pubmed publisher
    ..Thus, RalB signaling is a primary adaptive response to nutrient limitation that directly engages autophagocytosis through mobilization of the core vesicle nucleation machinery. ..
  50. Nichols C, Casanova J. Salmonella-directed recruitment of new membrane to invasion foci via the host exocyst complex. Curr Biol. 2010;20:1316-20 pubmed publisher
    ..We have identified a direct interaction between SipC and Exo70, a component of the exocyst complex, which mediates docking and fusion of exocytic vesicles with the plasma ..
  51. Germain M, Chatel Chaix L, Gagné B, Bonneil E, Thibault P, Pradezynski F, et al. Elucidating novel hepatitis C virus-host interactions using combined mass spectrometry and functional genomics approaches. Mol Cell Proteomics. 2014;13:184-203 pubmed publisher
    ..The study revealed highly stringent association between HCV interactors and their functional contribution to the viral replication cycle and pathogenesis. ..
  52. López Sánchez I, Ma G, Pedram S, Kalogriopoulos N, Ghosh P. GIV/girdin binds exocyst subunit-Exo70 and regulates exocytosis of GLUT4 storage vesicles. Biochem Biophys Res Commun. 2015;468:287-93 pubmed publisher
    ..These findings suggest a role of GIV in coordinating key signaling and trafficking events of metabolic insulin response. ..
  53. Holtmeier W, Hennemann A, Caspary W. IgA and IgM V(H) repertoires in human colon: evidence for clonally expanded B cells that are widely disseminated. Gastroenterology. 2000;119:1253-66 pubmed
    ..The human colon contains widely disseminated B cells that express clonally related IgA or IgM receptors. These results are best explained by an antigen-driven process whereby intestinal memory B cells continuously recirculate. ..
  54. Brymora A, Valova V, Larsen M, Roufogalis B, Robinson P. The brain exocyst complex interacts with RalA in a GTP-dependent manner: identification of a novel mammalian Sec3 gene and a second Sec15 gene. J Biol Chem. 2001;276:29792-7 pubmed
    ..Phospholipase D bound RalA in a nucleotide-independent manner. This places the RalA signaling system in mammalian nerve terminals, where the exocyst may act as an effector for activated RalA in directing sites of exocytosis. ..
  55. Zhao Y, Liu J, Yang C, Capraro B, Baumgart T, Bradley R, et al. Exo70 generates membrane curvature for morphogenesis and cell migration. Dev Cell. 2013;26:266-78 pubmed publisher
    ..Here, we demonstrate that Exo70, a component of the exocyst complex, induces tubular membrane invaginations toward the lumen of synthetic vesicles ..
  56. Soudeyns H, Champagne P, Holloway C, Silvestri G, Ringuette N, Samson J, et al. Transient T cell receptor beta-chain variable region-specific expansions of CD4+ and CD8+ T cells during the early phase of pediatric human immunodeficiency virus infection: characterization of expanded cell populations by T cell receptor phenotyping. J Infect Dis. 2000;181:107-20 pubmed
  57. Dewangan P, Sonawane P, Chouksey A, Chauhan R. The Nup62 Coiled-Coil Motif Provides Plasticity for Triple-Helix Bundle Formation. Biochemistry. 2017;56:2803-2811 pubmed publisher
    ..we show that the coiled-coil domain of Nup62 is sufficient for interaction with the coiled-coil domain of rat Exo70, a protein in an exocyst complex...
  58. Lu H, Liu J, Liu S, Zeng J, Ding D, Carstens R, et al. Exo70 isoform switching upon epithelial-mesenchymal transition mediates cancer cell invasion. Dev Cell. 2013;27:560-73 pubmed publisher
    ..Here, we show that Exo70, a component of the exocyst complex, undergoes isoform switching mediated by ESRP1, a pre-mRNA splicing factor ..
  59. Zhao Y, Hou J, Mi P, Mao L, Xu L, Zhang Y, et al. Exo70 is transcriptionally up-regulated by hepatic nuclear factor 4α and contributes to cell cycle control in hepatoma cells. Oncotarget. 2016;7:9150-62 pubmed publisher
    b>Exo70, a member of the exocyst complex, is involved in cell exocytosis, migration, invasion and autophagy. However, the expression regulation and function of Exo70 in hepatocellular carcinoma are still poorly understood...
  60. Ren J, Guo W. ERK1/2 regulate exocytosis through direct phosphorylation of the exocyst component Exo70. Dev Cell. 2012;22:967-78 pubmed publisher
    ..Here we show that the exocyst component Exo70 is a direct substrate of the extracellular signal-regulated kinases 1/2 (ERK1/2)...
  61. Lu H, Liu S, Zhang G, Kwong L, Zhu Y, Miller J, et al. Oncogenic BRAF-Mediated Melanoma Cell Invasion. Cell Rep. 2016;15:2012-24 pubmed publisher
    ..Mechanistically, BRAF(V600E) induces phosphorylation of cortactin and the exocyst subunit Exo70 through ERK, which regulates actin dynamics and matrix metalloprotease secretion, respectively...
  62. Ignatovich O, Tomlinson I, Popov A, Bruggemann M, Winter G. Dominance of intrinsic genetic factors in shaping the human immunoglobulin Vlambda repertoire. J Mol Biol. 1999;294:457-65 pubmed
    ..Therefore, transgenic mice represent a good model for analysis of the human antibody repertoire and for the production of human antibodies. ..