EXOC2

Summary

Gene Symbol: EXOC2
Description: exocyst complex component 2
Alias: SEC5, SEC5L1, Sec5p, SEC5-like 1, exocyst complex component Sec5
Species: human

Top Publications

  1. ncbi A conditional sterol esterification defect in yeast having either a sec1 or sec5 mutation in the secretory pathway
    M E Tomeo
    Department of Microbiology, North Carolina State University, Raleigh 27695 7615, USA
    Yeast 13:449-62. 1997
  2. ncbi Genetic determinants of hair, eye and skin pigmentation in Europeans
    Patrick Sulem
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nat Genet 39:1443-52. 2007
  3. ncbi Mutations in the exocyst component Sec5 disrupt neuronal membrane traffic, but neurotransmitter release persists
    Mala Murthy
    Department of Molecular and Cellular Physiology, Stanford University, Stanford, CA 94305, USA
    Neuron 37:433-47. 2003
  4. ncbi Ral-regulated interaction between Sec5 and paxillin targets Exocyst to focal complexes during cell migration
    Krystle S Spiczka
    Department of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Cell Sci 121:2880-91. 2008
  5. pmc A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation
    Jiali Han
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 4:e1000074. 2008
  6. pmc Subunit structure of the mammalian exocyst complex
    Y Kee
    Howard Hughes Medical Institute, Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford CA 94305 5428, USA
    Proc Natl Acad Sci U S A 94:14438-43. 1997
  7. ncbi The exocyst complex binds the small GTPase RalA to mediate filopodia formation
    Kazuhiro Sugihara
    Hematology Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Cell Biol 4:73-8. 2002
  8. ncbi Ral GTPases regulate exocyst assembly through dual subunit interactions
    Serge Moskalenko
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9039, USA
    J Biol Chem 278:51743-8. 2003
  9. ncbi Subunit composition, protein interactions, and structures of the mammalian brain sec6/8 complex and septin filaments
    S C Hsu
    Howard Hughes Medical Institute, Department of Molecular and Cellular Physiology, Stanford University School of Medicine, California 94305, USA
    Neuron 20:1111-22. 1998
  10. pmc Exo84 and Sec5 are competitive regulatory Sec6/8 effectors to the RalA GTPase
    Rongsheng Jin
    Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305 5432, USA
    EMBO J 24:2064-74. 2005

Scientific Experts

  • Peter J Novick
  • Alan R Saltiel
  • Philippe Chavrier
  • Sophie G Martin
  • Sean Munro
  • Charles Yeaman
  • DAVID JOHN HUNTER
  • Manfred Kayser
  • H Y Gaisano
  • DOUGLAS FREDERICK LEVINSON
  • Akane Imai
  • Dermot P B McGovern
  • Hongmei Nan
  • Herwig Ponstingl
  • U Tepass
  • Helen R Mott
  • Thomas Schwarz
  • Jeran K Stratford
  • Mala Murthy
  • Wei Guo
  • Xiao Wei Chen
  • Jacques Camonis
  • Stephan DiSean Kendall
  • STEPHAN KENDALL
  • Timothy D Martin
  • Thomas L Schwarz
  • Hiroki Takeuchi
  • Yuchen Chien
  • Ivan Kulich
  • Rita O Teodoro
  • Viktor Zarsky
  • Jiali Han
  • Michal Hála
  • Mikael Sjölinder
  • Michael A White
  • Z Zeng
  • Mingfeng Zhang
  • Michal Simíček
  • Li Xie
  • Slobodan Beronja
  • Channing J Der
  • Joya Mukerji
  • Felipe O Bendezú
  • Shuya Fukai
  • C Clayton Hazelett
  • Weronica Ek
  • Fatima Cvrčková
  • Nobumichi Furuta
  • Adam G Sowalsky
  • Wojciech Branicki
  • Jesús Sánchez-Ruiz
  • Atsuo Amano
  • Peter Kraft
  • Tamara Pecenková
  • Richard H Scheller
  • Christina D Nichols
  • Yolanda T Chong
  • Sameer H Issaq
  • Zhong Wu
  • F Javier Pérez-Victoria
  • R Brynmor Fenwick
  • Sunil Prasannan
  • Louise J Campbell
  • Darerca Owen
  • Daniel Nietlispach
  • Hiroki Ishikawa
  • R Bryn Fenwick
  • Alex H Hutagalung
  • Krystle S Spiczka
  • Mitsunori Kawato
  • Tetsuya Saito
  • Chang Run Li
  • Hisayoshi Yoshizaki
  • Patrick Sulem
  • Graca Raposo
  • Marc Pypaert
  • Michiyuki Matsuda
  • Sunil Q Mehta
  • Katsuya Okawa
  • Takashi Tsuboi
  • Bernhard Sommer
  • Johanna Langevin
  • Rongsheng Jin
  • Charles Boyd
  • Andreas Wiederkehr
  • Shu Chan Hsu
  • Axel T Brunger
  • Li Wang
  • Sheng Wang
  • Akiyuki Takaya

Detail Information

Publications80

  1. ncbi A conditional sterol esterification defect in yeast having either a sec1 or sec5 mutation in the secretory pathway
    M E Tomeo
    Department of Microbiology, North Carolina State University, Raleigh 27695 7615, USA
    Yeast 13:449-62. 1997
    Two temperature-conditional secretory mutations, sec1 and sec5, cause the accumulation of post-Golgi vesicles when strains containing these mutations are grown at 37 degrees C...
  2. ncbi Genetic determinants of hair, eye and skin pigmentation in Europeans
    Patrick Sulem
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nat Genet 39:1443-52. 2007
    ..3 is associated with freckles. The fifth region provided refinements to a previously reported association in OCA2, and the sixth encompasses previously described variants in MC1R...
  3. ncbi Mutations in the exocyst component Sec5 disrupt neuronal membrane traffic, but neurotransmitter release persists
    Mala Murthy
    Department of Molecular and Cellular Physiology, Stanford University, Stanford, CA 94305, USA
    Neuron 37:433-47. 2003
    ..We have investigated exocyst function in Drosophila with mutations in one member of the complex, sec5. Null alleles die as growth-arrested larvae, whose neuromuscular junctions fail to expand...
  4. ncbi Ral-regulated interaction between Sec5 and paxillin targets Exocyst to focal complexes during cell migration
    Krystle S Spiczka
    Department of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Cell Sci 121:2880-91. 2008
    ..by extension, targeting of Exocyst-dependent cargo, is dependent on Ral GTPases, which control association between Sec5 and paxillin...
  5. pmc A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation
    Jiali Han
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 4:e1000074. 2008
    ..that the association between rs12203592 and hair color was independent of rs1540771, a SNP between the IRF4 and EXOC2 genes previously found to be associated with hair color...
  6. pmc Subunit structure of the mammalian exocyst complex
    Y Kee
    Howard Hughes Medical Institute, Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford CA 94305 5428, USA
    Proc Natl Acad Sci U S A 94:14438-43. 1997
    ..mAbs were generated to the mammalian rsec6 subunit of the exocyst complex. rsec6 immunoreactivity is found in a punctate distribution at terminals of PC12 cell processes at or near sites of granule exocytosis...
  7. ncbi The exocyst complex binds the small GTPase RalA to mediate filopodia formation
    Kazuhiro Sugihara
    Hematology Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Cell Biol 4:73-8. 2002
    ..We identified the mammalian homologue of Sec5, a subunit of the exocyst complex determining yeast cell polarity, as a specific binding partner for GTP-ligated ..
  8. ncbi Ral GTPases regulate exocyst assembly through dual subunit interactions
    Serge Moskalenko
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9039, USA
    J Biol Chem 278:51743-8. 2003
    ..Ral GTPases regulate exocyst-dependent vesicle trafficking and are required for exocyst complex assembly. Sec5, a membrane-associated exocyst subunit, has been identified as a direct target of activated Ral; however, the ..
  9. ncbi Subunit composition, protein interactions, and structures of the mammalian brain sec6/8 complex and septin filaments
    S C Hsu
    Howard Hughes Medical Institute, Department of Molecular and Cellular Physiology, Stanford University School of Medicine, California 94305, USA
    Neuron 20:1111-22. 1998
    ..The sec6/8 and septin complexes likely play an important role in trafficking vesicles and organizing proteins at the plasma membrane of neurons...
  10. pmc Exo84 and Sec5 are competitive regulatory Sec6/8 effectors to the RalA GTPase
    Rongsheng Jin
    Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305 5432, USA
    EMBO J 24:2064-74. 2005
    ..Two subunits of the Sec6/8 complex, Exo84 and Sec5, have recently been shown to be effector targets for active Ral GTPases...
  11. pmc Structural basis of the interaction between RalA and Sec5, a subunit of the sec6/8 complex
    Shuya Fukai
    Howard Hughes Medical Institute and Department of Molecular and Cellular Physiology, Stanford University, James H Clark Center, E300C, 318 Campus Drive, Stanford, CA 94305 5432, USA
    EMBO J 22:3267-78. 2003
    ..The Sec5 subunit of the mammalian sec6/8 complex binds Ral in a GTP-dependent manner...
  12. ncbi The exocyst component Sec5 is required for membrane traffic and polarity in the Drosophila ovary
    Mala Murthy
    Division of Neuroscience, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Development 131:377-88. 2004
    ..We describe the role of Sec5, a member of the exocyst complex, in directed membrane traffic in the Drosophila oocyte...
  13. pmc Ral and Rheb GTPase activating proteins integrate mTOR and GTPase signaling in aging, autophagy, and tumor cell invasion
    Timothy D Martin
    University of North Carolina at Chapel Hill, Department of Pharmacology, Lineberger Comprehensive Cancer Center, Chapel Hill, NC 27514, USA
    Mol Cell 53:209-20. 2014
    ..Additionally, RalGAP suppression in mammalian cells caused RalB-selective activation and Sec5- and exocyst-dependent engagement of mTORC1 and suppression of autophagy...
  14. pmc Ral mediates activity-dependent growth of postsynaptic membranes via recruitment of the exocyst
    Rita O Teodoro
    The F M Kirby Neurobiology Center, Department of Neurology, Boston Children s Hospital, Boston, MA, USA
    EMBO J 32:2039-55. 2013
    ..SSR growth requires Ral and the exocyst component Sec5 and Ral-induced enlargement of these membrane folds does not occur in sec5(-/-) muscles...
  15. pmc Ang2/fat-free is a conserved subunit of the Golgi-associated retrograde protein complex
    F Javier Pérez-Victoria
    Cell Biology and Metabolism Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Biol Cell 21:3386-95. 2010
    ..These findings indicate that Ang2 is the missing component of the GARP complex in most eukaryotes...
  16. pmc Genome-wide association studies identify several new loci associated with pigmentation traits and skin cancer risk in European Americans
    Mingfeng Zhang
    Clinical Research Program, Department of Dermatology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Hum Mol Genet 22:2948-59. 2013
    ..8 × 10(-8) in the discovery set and P = 6.7 × 10(-7) in the replication set), rs12202284 between IRF4 and EXOC2 (P = 5.0 × 10(-8); P = 6.6 × 10(-7) in the discovery set and P = 3...
  17. ncbi Arabidopsis exocyst subcomplex containing subunit EXO70B1 is involved in autophagy-related transport to the vacuole
    Ivan Kulich
    Department of Experimental Plant Biology, Faculty of Sciences, Charles University, Prague, Czech Republic Institute of Experimental Botany, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Traffic 14:1155-65. 2013
    ..EXO70B1 interacts with SEC5 and EXO84 and forms an exocyst subcomplex involved in autophagy-related, Golgi-independent membrane traffic to the ..
  18. ncbi RalA-exocyst interaction mediates GTP-dependent exocytosis
    Li Wang
    Division of Cellular and Molecular Biology, Toronto Western Research Institute, University Health Network, Department of Physiology, University of Toronto, 399 Bathurst Street, Toronto, Ontario M5T 2S8, Canada
    J Biol Chem 279:19875-81. 2004
    ..A Ral-binding fragment from Sec5, a component of the exocyst complex, showed a similar inhibition...
  19. pmc Proteomic analysis of HIV-1 Nef cellular binding partners reveals a role for exocyst complex proteins in mediating enhancement of intercellular nanotube formation
    Joya Mukerji
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, MA, USA
    Retrovirology 9:33. 2012
    ..Nef associates with and activates Pak2, a kinase that regulates T-cell signaling and actin cytoskeleton dynamics, but how Nef promotes nanotube formation is unknown...
  20. pmc Genome-wide association studies of pit-and-fissure- and smooth-surface caries in permanent dentition
    Z Zeng
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    J Dent Res 92:432-7. 2013
    ..g., CXCR1 and CXCR2, p value = 1.9E-6). This study supports the notion that genes differentially affect cariogenesis across the surfaces of the permanent dentition, and nominates several novel genes for investigation...
  21. pmc Evolution of the land plant exocyst complexes
    Fatima Cvrčková
    Department of Experimental Plant Biology, Faculty of Sciences, Charles University Prague, Czech Republic
    Front Plant Sci 3:159. 2012
    ..Homologs of its eight canonical subunits - Sec3, Sec5, Sec6, Sec8, Sec10, Sec15, Exo70, and Exo84 - were found also in higher plants and confirmed to form complexes in ..
  22. ncbi Genome-wide association study of multiplex schizophrenia pedigrees
    Douglas F Levinson
    Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, Calif, USA
    Am J Psychiatry 169:963-73. 2012
    ..The authors used a genome-wide association study (GWAS) of multiply affected families to investigate the association of schizophrenia to common single-nucleotide polymorphisms (SNPs) and rare copy number variants (CNVs)...
  23. pmc Exocyst sec5 regulates exocytosis of newcomer insulin granules underlying biphasic insulin secretion
    Li Xie
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 8:e67561. 2013
    The exocyst complex subunit Sec5 is a downstream effector of RalA-GTPase which promotes RalA-exocyst interactions and exocyst assembly, serving to tether secretory granules to docking sites on the plasma membrane...
  24. ncbi The deubiquitylase USP33 discriminates between RALB functions in autophagy and innate immune response
    Michal Simíček
    1 VIB Center for the Biology of Disease, VIB, 3000 Leuven, Belgium 2 Department of Human Genetics, KU Leuven, Herestraat 49, 3000 Leuven, Belgium
    Nat Cell Biol 15:1220-30. 2013
    ..nutrient availability or viral infection by respectively engaging two components of the exocyst complex, EXO84 and SEC5. RALB employs SEC5 to trigger innate immunity signalling, whereas RALB-EXO84 interaction induces autophagocytosis...
  25. doi Mapping QTL affecting a systemic sclerosis-like disorder in a cross between UCD-200 and red jungle fowl chickens
    Weronica Ek
    Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden
    Dev Comp Immunol 38:352-9. 2012
    ..Three orthologues of genes implicated in human SSc are located in the QTL region on chromosome 2, TGFRB1, EXOC2-IRF4 and COL1A2, as well as CCR8, which is more generally related to immune function...
  26. doi Exocyst subunits are involved in isoproterenol-induced amylase release from rat parotid acinar cells
    Akane Imai
    Department of Biochemistry, School of Life Dentistry at Niigata, The Nippon Dental University, Chuo Ku, Niigata, Japan
    Eur J Oral Sci 120:123-31. 2012
    ..The exocyst complex, which is composed of eight subunits (Sec3, Sec5, Sec6, Sec8, Sec10, Sec15, Exo70, and Exo84) that are conserved in yeast and mammalian cells, is thought to ..
  27. pmc Fission yeast Sec3 and Exo70 are transported on actin cables and localize the exocyst complex to cell poles
    Felipe O Bendezú
    Department of Fundamental Microbiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland
    PLoS ONE 7:e40248. 2012
    ..However, we show that Sec3, Exo70 and Sec5 are transported by the myosin V Myo52 along actin cables...
  28. pmc Sec5 and Exo84 mediate distinct aspects of RalA-dependent cell polarization
    C Clayton Hazelett
    Department of Anatomy and Cell Biology Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America
    PLoS ONE 7:e39602. 2012
    ..Blocking RalA-Exocyst binding caused significant morphological changes and defects in single and coordinated cell migration...
  29. pmc Sec5, a member of the exocyst complex, mediates Drosophila embryo cellularization
    Mala Murthy
    The F M Kirby Neurobiology Center, Children s Hospital, Boston, MA 02115, USA
    Development 137:2773-83. 2010
    ..b>Sec5 is a central component of this complex and we here report the isolation of a new allele of sec5 that has a ..
  30. ncbi STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
    Hiroki Ishikawa
    Department of Medicine and Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Nature 461:788-92. 2009
    ..TBK1) from the endoplasmic reticulum to perinuclear vesicles containing the exocyst component Sec5 (also known as EXOC2)...
  31. pmc Salmonella-directed recruitment of new membrane to invasion foci via the host exocyst complex
    Christina D Nichols
    Department of Microbiology, University of Virginia Health System, Charlottesville, VA 22908 0732, USA
    Curr Biol 20:1316-20. 2010
    ..Knockdown of RalA or Sec5 results in reduced membrane ruffling at sites of attachment and impairs bacterial entry into host cells...
  32. pmc Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease
    Dermot P B McGovern
    Inflammatory Bowel and Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Hum Mol Genet 19:3468-76. 2010
    ..associations with genes involved in tight junctions/epithelial integrity (ASHL, ARPC1A), innate immunity (EXOC2), dendritic cell biology [CADM1 (IGSF4)], macrophage development (MMD2), TGF-beta signaling (MAP3K7IP1) and FUT2 (..
  33. pmc Sec5 and Exo84 foster oncogenic ras-mediated tumorigenesis
    Sameer H Issaq
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, DUMC 3813, Durham, NC 27710, USA
    Mol Cancer Res 8:223-31. 2010
    ..Here, we report that shRNA-mediated knockdown of the Ral effector proteins Sec5 and Exo84, but less so in the case of RalBP1, reduced oncogenic RalGEF-mediated transformation and oncogenic Ras-..
  34. ncbi Characterization of the Arabidopsis thaliana exocyst complex gene families by phylogenetic, expression profiling, and subcellular localization studies
    Yolanda T Chong
    Department of Cell and Systems Biology and the Centre for the Analysis of Genome Evolution and Function, University of Toronto, Toronto, Ontario, Canada M5S 3B2
    New Phytol 185:401-19. 2010
    The exocyst is a complex of eight proteins (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p and Exo84p) involved in tethering vesicles to the plasma membrane during regulated or polarized secretion...
  35. doi The RalB-RLIP76 complex reveals a novel mode of ral-effector interaction
    R Brynmor Fenwick
    Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK
    Structure 18:985-95. 2010
    ..complex reveals a novel mode of binding compared to the structures of RalA complexed with the exocyst components Sec5 and Exo84...
  36. doi Exit of intracellular Porphyromonas gingivalis from gingival epithelial cells is mediated by endocytic recycling pathway
    Hiroki Takeuchi
    Department of Oral Frontier Biology, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan
    Cell Microbiol 13:677-91. 2011
    ..Dominant negative forms and RNAi knockdown of Rab11, RalA and exocyst complex subunits (Sec5, Sec6 and Exo84) significantly disturbed the exit of P. gingivalis...
  37. pmc The Sec6/8 complex in mammalian cells: characterization of mammalian Sec3, subunit interactions, and expression of subunits in polarized cells
    H T Matern
    Genentech, Inc, Department of Richard Scheller, South San Francisco, CA 94080 4990, USA
    Proc Natl Acad Sci U S A 98:9648-53. 2001
    ..17% sequence identity with yeast Sec3p, interacts in the two-hybrid system with other subunits of the complex (Sec5 and Sec8), and is expressed in almost all tissues tested...
  38. pmc Cell entry and exit by periodontal pathogen via recycling pathway
    Hiroki Takeuchi
    Department of Oral Frontier Biology Center for Frontier Oral Science Osaka University Graduate School of Dentistry Osaka, Japan
    Commun Integr Biol 4:587-9. 2011
    ..However, dominant negative forms and RNAi-knockdown of Rab11, RalA and exocyst complex subunits (Sec5, Sec6 and Exo84) significantly disturb the exit of P. gingivalis...
  39. doi Ral GTPases regulate cell-mediated cytotoxicity in NK cells
    Jesús Sánchez-Ruiz
    Departamento de Inmunologia y Oncologia, Centro Nacional de Biotecnología Consejo Superior Investigaciones Científicas, E 28049 Madrid, Spain
    J Immunol 187:2433-41. 2011
    ..This assembly is required for degranulation, as interference with expression of the exocyst component Sec5 led to reduced degranulation and impaired cytotoxicity in NK cells...
  40. pmc Genome-wide association study identifies novel alleles associated with risk of cutaneous basal cell carcinoma and squamous cell carcinoma
    Hongmei Nan
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Hum Mol Genet 20:3718-24. 2011
    ..55 (1.45-1.66); P= 4.3 × 10(-17)]. We identified that an SNP rs12210050 at 6p25 near the EXOC2 gene was associated with an increased risk of BCC [rs12210050[T]: combined OR (95% CI), 1.24 (1.17-1.31); P= 9...
  41. ncbi Ral's engagement with the exocyst: breaking up is hard to do
    Xiao Wei Chen
    Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA
    Cell Cycle 10:2299-304. 2011
    ..Disengagement between the GTPase and the exocyst occurs through phosphorylation of its effector Sec5 in its Ral-binding domain, thus allowing continuation of exocytic program and recycling of the tether...
  42. pmc Exocyst function is regulated by effector phosphorylation
    Xiao Wei Chen
    Life Sciences Institute, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    Nat Cell Biol 13:580-8. 2011
    ..after recognition of the exocyst by activated RalA, disengagement occurs through phosphorylation of its effector Sec5, rather than RalA inactivation...
  43. pmc Activation and involvement of Ral GTPases in colorectal cancer
    Timothy D Martin
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Cancer Res 71:206-15. 2011
    ..Interestingly, RalA interaction with the Exo84 but not Sec5 exocyst component was necessary for supporting anchorage-independent growth, whereas RalB interaction with Sec5 but ..
  44. pmc RalBP1 is necessary for metastasis of human cancer cell lines
    Zhong Wu
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA, USA
    Neoplasia 12:1003-12. 2010
    ..RNA-mediated depletion of Ral effectors Ral binding protein 1 (RalBP1/RLIP), exocyst complex component 2 (Sec5), and phospholipase D1 (PLD1) and found that RalBP1 and RalA depletion inhibited cell migration to a similar extent...
  45. pmc RalA function in dermal fibroblasts is required for the progression of squamous cell carcinoma of the skin
    Adam G Sowalsky
    Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, Massachusetts, USA
    Cancer Res 71:758-67. 2011
    ..at least in part, by mediating hepatocyte growth factor (HGF) secretion through its effector proteins, the Sec5 and Exo84 subunits of the exocyst complex...
  46. pmc Model-based prediction of human hair color using DNA variants
    Wojciech Branicki
    Section of Forensic Genetics, Institute of Forensic Research, Westerplatte 9, 31 033, Krakow, Poland
    Hum Genet 129:443-54. 2011
    ....
  47. pmc Genome-wide association study of tanning phenotype in a population of European ancestry
    Hongmei Nan
    Channing Laboratory, Department of Medicine, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Invest Dermatol 129:2250-7. 2009
    ..Overall, these tanning ability-related loci are similar to the hair color-related loci previously reported in the GWAS of hair color...
  48. ncbi Solution structure and dynamics of the small GTPase RalB in its active conformation: significance for effector protein binding
    R Bryn Fenwick
    Department of Biochemistry, University of Cambridge, UK
    Biochemistry 48:2192-206. 2009
    ..Crystal structures of RalA in the free form and in complex with its effectors, Sec5 and Exo84, have been solved...
  49. ncbi The exocyst complex in polarized exocytosis
    Shu Chan Hsu
    Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, New Jersey 08854, USA
    Int Rev Cytol 233:243-65. 2004
    ..The exocyst consists of eight components: Sec3, Sec5, Sec6, Sec8, Sec10, Sec15, Exo70, and Exo84...
  50. pmc RalA activation at nascent lamellipodia of epidermal growth factor-stimulated Cos7 cells and migrating Madin-Darby canine kidney cells
    Akiyuki Takaya
    Department of Tumor Virology, Research Institute for Microbial Diseases, Osaka University, Yamadaoka, Suita Shi, Osaka 565 0871, Japan
    Mol Biol Cell 15:2549-57. 2004
    ..EGF-induced lamellipodial protrusion was inhibited by microinjection of the RalA-binding domains of RalBP1 and Sec5. Furthermore, we found that RalA activity was high at the lamellipodia of migrating Madin-Darby canine kidney cells ..
  51. ncbi Characterisation of an evolutionary conserved protein interacting with the putative guanine nucleotide exchange factor DelGEF and modulating secretion
    Mikael Sjölinder
    Division for Molecular Biology of Mitosis, German Cancer Research Center, D 69120 Heidelberg, Germany
    Exp Cell Res 294:68-76. 2004
    ..DelGEF was recently shown to interact with Sec5, a protein involved in secretion, and to regulate secretion of proteoglycans...
  52. pmc Sec6, Sec8, and Sec15 are components of a multisubunit complex which localizes to small bud tips in Saccharomyces cerevisiae
    D R Terbush
    Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Cell Biol 130:299-312. 1995
    ..The composition of the Sec6/8/15 complex is disrupted specifically in the sec3-2, sec5-24, and sec10-2 strain backgrounds...
  53. pmc ARF6 controls post-endocytic recycling through its downstream exocyst complex effector
    Magali Prigent
    Membrane and Cytoskeleton Dynamics Group, UMR144 Centre National de la Recherche Scientifique, Institut Curie, 26 Rue d Ulm, F 75248 Paris Cedex 05, France
    J Cell Biol 163:1111-21. 2003
    ..In addition, we report that depletion of Sec5 exocyst subunit or dominant inhibition of Sec10 affects the function and the morphology of the recycling pathway...
  54. ncbi The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin
    Mayumi Inoue
    Life Sciences Institute, Departments of Internal Medicine and Physiology, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    Nature 422:629-33. 2003
    ..So, the exocyst might have a crucial role in the targeting of the Glut4 vesicle to the plasma membrane, perhaps directing the vesicle to the precise site of fusion...
  55. ncbi Structure of the GTPase-binding domain of Sec5 and elucidation of its Ral binding site
    Helen R Mott
    Department of Biochemistry, University of Cambridge, 80, Tennis Court Road, Cambridge CB2 1GA, United Kingdom
    J Biol Chem 278:17053-9. 2003
    ..of the exocyst complex in mammals was recently shown to be dependent upon binding of the small G protein, Ral, to Sec5, a central component of the exocyst...
  56. ncbi DelGEF, a homologue of the Ran guanine nucleotide exchange factor RanGEF, binds to the exocyst component Sec5 and modulates secretion
    Mikael Sjölinder
    Division for Molecular Biology of Mitosis, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    FEBS Lett 532:211-5. 2002
    ..The human homologue of Sec5, a protein involved in vesicle transport and secretion, was identified as a binding partner...
  57. ncbi Compartmentalization of the cell cortex by septins is required for maintenance of cell polarity in yeast
    Y Barral
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA
    Mol Cell 5:841-51. 2000
    ..that cells lacking septins at the bud neck failed to maintain the exocytosis and morphogenesis factors Spa2, Sec3, Sec5, and Myo2 in the bud during isotropic growth...
  58. ncbi Exo84p is an exocyst protein essential for secretion
    W Guo
    Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06520 8002, USA
    J Biol Chem 274:23558-64. 1999
    ..The assembly of Exo84p into the exocyst complex requires two other subunits, Sec5p and Sec10p. Exo84p interacts with both Sec5p and Sec10p in a two-hybrid assay...
  59. pmc Sec3p is involved in secretion and morphogenesis in Saccharomyces cerevisiae
    F P Finger
    Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06520 8002, USA
    Mol Biol Cell 8:647-62. 1997
    ..The SEC3 gene in high copy suppresses pfy1-111 and sec5-24 and causes synthetic growth defects with ypt1, sec8-9, sec10-2, and sec15-1...
  60. ncbi Synaptotagmin II expression partially rescues the growth defect of the yeast sec15 secretory mutant
    C K Damer
    Department of Pharmacology, University of Virginia, Charlottesville 22908, USA
    Biol Cell 88:55-63. 1996
    ..No suppression was observed when synaptotagmin II was expressed in sec1, sec2, sec4, sec5, sec6, sec8, sec9, sec14, sec17, or sec18...
  61. pmc The Exocyst is a multiprotein complex required for exocytosis in Saccharomyces cerevisiae
    D R Terbush
    Yale University School of Medicine, Department of Cell Biology, New Haven, CT 06520 8002, USA
    EMBO J 15:6483-94. 1996
    ..possibility, we cloned and sequenced the SEC5 and SEC10 genes, disrupted them, and either epitope tagged them (Sec5p) or prepared polyclonal antisera (Sec10p) to them for co-immunoprecipitation studies...
  62. ncbi The mammalian exocyst, a complex required for exocytosis, inhibits tubulin polymerization
    Sheng Wang
    Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, New Jersey 08854, USA
    J Biol Chem 279:35958-66. 2004
    ..Deletion of exocyst subunit sec5, sec6, sec15, or exo70 diminished its tubulin polymerization inhibition activity...
  63. pmc Functional specialization within a vesicle tethering complex: bypass of a subset of exocyst deletion mutants by Sec1p or Sec4p
    Andreas Wiederkehr
    Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06510, USA
    J Cell Biol 167:875-87. 2004
    ..Sec3p and Sec5p are more critical than Exo70p for ER inheritance...
  64. pmc Vesicles carry most exocyst subunits to exocytic sites marked by the remaining two subunits, Sec3p and Exo70p
    Charles Boyd
    Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Cell Biol 167:889-901. 2004
    ..One subset (Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, and Exo84p) exhibits mobility similar to that of the vesicle-bound Rab family ..
  65. pmc An internal domain of Exo70p is required for actin-independent localization and mediates assembly of specific exocyst components
    Alex H Hutagalung
    Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    Mol Biol Cell 20:153-63. 2009
    ..it leads to synthetic lethality with many secretory mutations, defects in exocyst assembly of exocyst components Sec5p and Sec6p, and loss of actin-independent localization...
  66. pmc An exocyst complex functions in plant cell growth in Arabidopsis and tobacco
    Michal Hála
    Institute of Experimental Botany, Academy of Sciences of the Czech Republic, 165 02 Prague 6, Czech Republic
    Plant Cell 20:1330-45. 2008
    ..Double mutants in exocyst subunits (sec5 exo70A1 and sec8 exo70A1) show a synergistic defect in etiolated hypocotyl elongation...
  67. ncbi Involvement of Exoc3l, a protein structurally related to the exocyst subunit Sec6, in insulin secretion
    Tetsuya Saito
    Division of Cellular and Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Biomed Res 29:85-91. 2008
    ..In co-immunoprecipitation experiments, Exoc3l was found to interact with Sec5, Sec8, and Sec10, all of which are binding partners of Sec6 in the exocyst complex...
  68. doi Characterization of RalB-Sec5-TBK1 function in human oncogenesis
    Yuchen Chien
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Methods Enzymol 438:321-9. 2008
    ..A direct Ral effector protein, Sec5, is a subunit of the exocyst complex, and is required to mediate RalB-dependent survival signals in transformed ..
  69. ncbi Regulation of platelet dense granule secretion by the Ral GTPase-exocyst pathway
    Mitsunori Kawato
    Department of Cardiovascular Medicine and Frontier Technology Center, Graduate School of Medicine, Kyoto University, Kyoto 606 8507, Japan
    J Biol Chem 283:166-74. 2008
    ..This secretion was inhibited by the addition of GTP-Ral-binding domain (RBD) of Sec5, which is a component of the exocyst complex known to function as a tethering factor at the plasma membrane for ..
  70. ncbi Candida albicans hyphal morphogenesis occurs in Sec3p-independent and Sec3p-dependent phases separated by septin ring formation
    Chang Run Li
    Candida albicans Molecular and Cell Biology Laboratory, Institute of Molecular and Cell Biology, 61 Biopolis Drive, 138673, Singapore
    J Cell Sci 120:1898-907. 2007
    ..Co-immunoprecipitation experiments detected association of the septin Cdc3p with the exocyst subunits Sec3p and Sec5p. Our results reveal that C...
  71. pmc Akt-PDK1 complex mediates epidermal growth factor-induced membrane protrusion through Ral activation
    Hisayoshi Yoshizaki
    Department of Structural Analysis, National Cardiovascular Center Research Institute, Osaka 565 8565, Japan
    Mol Biol Cell 18:119-28. 2007
    ..formation was promoted by the overexpression of Akt and inhibited by an Akt inhibitor or a Ral-binding domain of Sec5. These results identified the Akt-PDK1 complex as an upstream positive regulator of Ral GTPase in the induction of ..
  72. ncbi RalB GTPase-mediated activation of the IkappaB family kinase TBK1 couples innate immune signaling to tumor cell survival
    Yuchen Chien
    Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    Cell 127:157-70. 2006
    ..Reported effector proteins of RalB include the Sec5 component of the exocyst, an octameric protein complex implicated in tethering of vesicles to membranes...
  73. ncbi Drosophila exocyst components Sec5, Sec6, and Sec15 regulate DE-Cadherin trafficking from recycling endosomes to the plasma membrane
    Johanna Langevin
    Polarité Cellulaire chez la drosophile, UMR 144, Paris, France
    Dev Cell 9:365-76. 2005
    ..Loss of function of the Drosophila exocyst components sec5, sec6, and sec15 in epithelial cells results in DE-Cad accumulation in an enlarged Rab11 recycling endosomal ..
  74. pmc The exocyst component Sec5 is present on endocytic vesicles in the oocyte of Drosophila melanogaster
    Bernhard Sommer
    Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 2QH, England, UK
    J Cell Biol 169:953-63. 2005
    ..We have found that in Drosophila melanogaster oocytes the majority of the exocyst component Sec5 is unexpectedly present in clathrin-coated pits and vesicles at the plasma membrane...
  75. pmc Essential function of Drosophila Sec6 in apical exocytosis of epithelial photoreceptor cells
    Slobodan Beronja
    Department of Zoology, University of Toronto, Toronto, Ontario M5S 3G5, Canada
    J Cell Biol 169:635-46. 2005
    ..In developing photoreceptor cells (PRCs), Sec6 but not Sec5 or Sec8 shows accumulation at adherens junctions...
  76. ncbi Mammalian exocyst complex is required for the docking step of insulin vesicle exocytosis
    Takashi Tsuboi
    Henry Wellcome Laboratories for Integrated Cell Signalling and Department of Biochemistry, School of Medical Sciences, University Walk, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Biol Chem 280:25565-70. 2005
    ..We show first that SEC6 is concentrated on insulin-positive vesicles, whereas SEC5 and SEC8 are largely confined to the cytoplasm and the plasma membrane, respectively...
  77. ncbi Mutations in Drosophila sec15 reveal a function in neuronal targeting for a subset of exocyst components
    Sunil Q Mehta
    Program in Developmental Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Neuron 46:219-32. 2005
    ..Additionally, sec15 mutant neurons fail to localize other exocyst members like Sec5 and Sec8, but not Sec6, to neuronal terminals...
  78. ncbi Sec6 mutations and the Drosophila exocyst complex
    Mala Murthy
    Division of Neuroscience, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Cell Sci 118:1139-50. 2005
    ..We have used these mutations to compare the phenotypes of sec6 and sec5 in the ovary and nervous system, and we find them to be similar...
  79. pmc Yeast syntaxins Sso1p and Sso2p belong to a family of related membrane proteins that function in vesicular transport
    M K Aalto
    VTT Biotechnical Laboratory, Espoo, Finland
    EMBO J 12:4095-104. 1993
    ..copy number can suppress sec1 mutations and also mutations in several other late acting SEC genes, such as SEC3, SEC5, SEC9 and SEC15...

Research Grants70

  1. Role of cell adhesion in organizing membrane growth.
    CHARLES A YEAMAN; Fiscal Year: 2013
    ..Ral GTPases regulate different steps in Exocyst-dependent trafficking, through sequential interactions with the Sec5 and Exo84 subunits...
  2. The role of the exocyst in cell migration
    Wei Guo; Fiscal Year: 2013
    ..The exocyst, a multiprotein complex consisting of Sec3, Sec5, Sec6, Sec8, Sec10, Sec15, Exo70 and Exo84, mediates exocytosis and polarized cell surface expansion...
  3. Role of TTK/Mps-1 upregulation by Ral GTPase activation in pancreatic oncogenesis
    Jeran K Stratford; Fiscal Year: 2013
    ..RalBP1/RLIP76 and the Sec5 and Exo84 exocyst components are the best- characterized Ral effectors and I will determine if Ral mutants that ..
  4. Genetics of New Synaptic Components and Their Functions
    Thomas Schwarz; Fiscal Year: 2007
    ..We also propose a mutant screen to identify genes that interact closely with sec5, an exocyst component...
  5. Genetics of New Synaptic Components and Their Functions
    Thomas Schwarz; Fiscal Year: 2006
    ..We also propose a mutant screen to identify genes that interact closely with sec5, an exocyst component...
  6. Genetics of New Synaptic Components and Their Functions
    Thomas Schwarz; Fiscal Year: 2005
    ..We also propose a mutant screen to identify genes that interact closely with sec5, an exocyst component...
  7. Role of TTK/Mps-1 upregulation by Ral GTPase activation in pancreatic oncogenesis
    Jeran K Stratford; Fiscal Year: 2012
    ..RalBP1/RLIP76 and the Sec5 and Exo84 exocyst components are the best- characterized Ral effectors and I will determine if Ral mutants that ..
  8. The role of the Exocyst complex in insulin regulated glucose transport
    Alan R Saltiel; Fiscal Year: 2013
    ..along the final steps of the journey via actin cables to the exocyst, where it binds to the exocyst components Sec5 and Exo84...
  9. GENETICS OF SECRETION IN YEAST
    Peter Novick; Fiscal Year: 2004
    ..Tethering requires a complex containing Sec3, Sec5, Sec6, Sec8, SeclO, Secl5, Exo 70 and Exo84, termed the exocyst...
  10. GENETICS OF SECRETION IN YEAST
    Peter Novick; Fiscal Year: 2003
    ..Tethering requires a complex containing Sec3, Sec5, Sec6, Sec8, SeclO, Secl5, Exo 70 and Exo84, termed the exocyst...
  11. GENETICS OF SECRETION IN YEAST
    Peter Novick; Fiscal Year: 2002
    ..Tethering requires a complex containing Sec3, Sec5, Sec6, Sec8, SeclO, Secl5, Exo 70 and Exo84, termed the exocyst...
  12. GENETICS OF SECRETION IN YEAST
    Peter Novick; Fiscal Year: 2009
    ..Tethering requires a complex containing Sec3, Sec5, Sec6, Sec8, SeclO, SeclS, Exo 70 and Exo84, termed the exocyst....
  13. GENETICS OF SECRETION IN YEAST
    Peter Novick; Fiscal Year: 2005
    ..Tethering requires a complex containing Sec3, Sec5, Sec6, Sec8, SeclO, Secl5, Exo 70 and Exo84, termed the exocyst...
  14. GENETICS OF SECRETION IN YEAST
    Peter J Novick; Fiscal Year: 2010
    ..Tethering requires a complex containing Sec3, Sec5, Sec6, Sec8, SeclO, SeclS, Exo 70 and Exo84, termed the exocyst....
  15. GENETICS OF SECRETION IN YEAST
    Peter Novick; Fiscal Year: 2001
    ..Tethering requires a complex containing Sec3, Sec5, Sec6, Sec8, SeclO, Secl5, Exo 70 and Exo84, termed the exocyst...
  16. The role of RalA in pancreatic tumorigenesis
    STEPHAN KENDALL; Fiscal Year: 2009
    ..Specific Aim 2: Determine whether RalA functions through its known effectors RalBP1, Exo84, or Sec5 to mediate the development of pancreatic cancer...
  17. The role of RalA in pancreatic tumorigenesis
    Stephan DiSean Kendall; Fiscal Year: 2010
    ..Specific Aim 2: Determine whether RalA functions through its known effectors RalBP1, Exo84, or Sec5 to mediate the development of pancreatic cancer...
  18. GENETICS OF SECRETION IN YEAST
    Peter Novick; Fiscal Year: 2006
    ..Tethering requires a complex containing Sec3, Sec5, Sec6, Sec8, SedO, Sec15, Exo 70 and Exo84, termed the exocyst...
  19. MEMBRANE TRAFFIC IN NORMAL AND TRANSFORMED CELLS
    Peter Novick; Fiscal Year: 2007
    ..A possible cell cycle checkpoint for Golgi partitioning will be evaluated. ..
  20. Structure and Inheritance of the endoplasmic reticulum
    Peter Novick; Fiscal Year: 2006
    ..5) We will determine if ergosterol and sphingolipids are critical for the localization, mobility or activity of a cortical component of the machinery that establishes the structure, dynamics and inheritance of the ER. ..
  21. GENETICS OF SECRETION IN YEAST
    Peter Novick; Fiscal Year: 2007
    ..Tethering requires a complex containing Sec3, Sec5, Sec6, Sec8, SeclO, SeclS, Exo 70 and Exo84, termed the exocyst....
  22. Role of Cell Adhesion in Organizing Membrane Growth
    Charles Yeaman; Fiscal Year: 2009
    ....
  23. Role of Cell Adhesion in Organizing Membrane Growth
    Charles Yeaman; Fiscal Year: 2005
    ....
  24. COHORT STUDY OF GENETIC SUSCEPTIBILITY TO BREAST CANCER
    David Hunter; Fiscal Year: 2005
    ..5 or greater for the main effects of most of the genotypes of interest. We will also have substantial power to detect interactions between these genotypes and established breast cancer risk factors. ..
  25. Role of Cell Adhesion in Organizing Membrane Growth
    Charles Yeaman; Fiscal Year: 2007
    ....
  26. COHORT STUDY OF GENETIC SUSCEPTIBILITY TO BREAST CANCER
    DAVID JOHN HUNTER; Fiscal Year: 2010
    ..Understanding the causes of the age-related shortening of telomeres may offer modifiable means of reducing breast cancer risk. ..
  27. Susceptibility mechanism in alcoholic pancreatitis
    Herbert Gaisano; Fiscal Year: 2007
    ..Significance: These actions of alcohol on pancreatic acinar PM-Munc18c may be the 'sentinel' event that initiates the role of alcohol in pancreatic injury, and which could be therapeutically targeted. ..
  28. COHORT STUDY OF GENETIC SUSCEPTIBILITY TO BREAST CANCER
    David Hunter; Fiscal Year: 2009
    ..Understanding the causes of the age-related shortening of telomeres may offer modifiable means of reducing breast cancer risk. ..
  29. COHORT STUDY OF GENETIC MARKERS IN COLON CANCER
    David Hunter; Fiscal Year: 2005
    ..They conclude that confirmation of risk genotypes would also be useful in identifying persons at high risk of colon cancer and assist in focusing screening efforts. ..
  30. COHORT STUDY OF GENETIC SUSCEPTIBILITY TO BREAST CANCER
    David Hunter; Fiscal Year: 2002
    ..5 or greater for the main effects of most of the genotypes of interest. We will also have substantial power to detect interactions between these genotypes and established breast cancer risk factors. ..
  31. COHORT STUDY OF GENETIC SUSCEPTIBILITY TO BREAST CANCER
    David Hunter; Fiscal Year: 2003
    ..5 or greater for the main effects of most of the genotypes of interest. We will also have substantial power to detect interactions between these genotypes and established breast cancer risk factors. ..
  32. COHORT STUDY OF GENETIC MARKERS IN COLON CANCER
    David Hunter; Fiscal Year: 1999
    ..They conclude that confirmation of risk genotypes would also be useful in identifying persons at high risk of colon cancer and assist in focusing screening efforts. ..
  33. COHORT STUDY OF GENETIC SUSCEPTIBILITY TO BREAST CANCER
    David Hunter; Fiscal Year: 1999
    ..The availability of this information is critical to our ability to appropriately counsel women with these genotypes. ..
  34. COHORT STUDY OF GENETIC SUSCEPTIBILITY TO BREAST CANCER
    David Hunter; Fiscal Year: 2000
    ..The availability of this information is critical to our ability to appropriately counsel women with these genotypes. ..
  35. COHORT STUDY OF GENETIC SUSCEPTIBILITY TO BREAST CANCER
    David Hunter; Fiscal Year: 2007
    ..Understanding the causes of the age-related shortening of telomeres may offer modifiable means of reducing breast cancer risk. ..
  36. MULTICENTER GENETIC STUDIES OF SCHIZOPHRENIA
    Douglas Levinson; Fiscal Year: 2000
    ..These studies may assist investigators in determining which candidate regions are most deserving of intensive efforts to find disease-related genes, and the most likely locations of these genes within the regions. ..
  37. Genome-Wide Association Study of Schizophrenia
    Douglas Levinson; Fiscal Year: 2007
    ....
  38. MULTICENTER GENETIC STUDIES OF SCHIZOPHRENIA
    Douglas Levinson; Fiscal Year: 2001
    ..These studies may assist investigators in determining which candidate regions are most deserving of intensive efforts to find disease-related genes, and the most likely locations of these genes within the regions. ..
  39. GENETICS OF RECURRENT EARLY-ONSET DEPRESSION
    Douglas Levinson; Fiscal Year: 2001
    ..A timetable is proposed for rapid sharing of all biological materials, blinded clinical data, genotypes and linkage analyses with the scientific community through the NIMH-sponsored Center for Genetic Studies. ..
  40. MOLECULAR GENETICS OF SCHIZOPHRENIA
    Douglas Levinson; Fiscal Year: 2001
    ..Power analyses suggest that this study would have excellent power to detect loci associated with lambda sibs of 1.4, and moderate power for a value of 1.3, i.e., loci with relatively small etiologic effects. ..
  41. MOLECULAR GENETICS OF SCHIZOPHRENIA
    Douglas Levinson; Fiscal Year: 1999
    ..Power analyses suggest that this study would have excellent power to detect loci associated with lambda sibs of 1.4, and moderate power for a value of 1.3, i.e., loci with relatively small etiologic effects. ..
  42. GENETICS OF RECURRENT EARLY-ONSET DEPRESSION
    Douglas Levinson; Fiscal Year: 2000
    ..A timetable is proposed for rapid sharing of all biological materials, blinded clinical data, genotypes and linkage analyses with the scientific community through the NIMH-sponsored Center for Genetic Studies. ..
  43. MOLECULAR GENETICS OF SCHIZOPHRENIA
    Douglas Levinson; Fiscal Year: 2002
    ..Power analyses suggest that this study would have excellent power to detect loci associated with lambda sibs of 1.4, and moderate power for a value of 1.3, i.e., loci with relatively small etiologic effects. ..
  44. Genetics of Early-Onset Depression
    Douglas Levinson; Fiscal Year: 2007
    ..abstract_text> ..
  45. GENETIC LINKAGE OF SCHIZOPHRENIA AND RELATED STUDIES
    Douglas Levinson; Fiscal Year: 2005
    ..abstract_text> ..
  46. Genetics of Early-Onset Depression
    Douglas Levinson; Fiscal Year: 2005
    ..abstract_text> ..
  47. MOLECULAR GENETICS OF SCHIZOPHRENIA
    Douglas Levinson; Fiscal Year: 2004
    ..The goal of the study is to identify one or more SZ susceptibility genes whose subsequent characterization inmolecular and functional studies will elucidate the pathophysiology and treatment of SZ. ..
  48. Genetics of Early-Onset Depression
    Douglas Levinson; Fiscal Year: 2005
    ..abstract_text> ..
  49. Multicenter Genetics Studies of Schizophrenia
    Douglas Levinson; Fiscal Year: 2005
    ....
  50. MULTICENTER GENETIC STUDIES OF SCHIZOPHRENIA
    Douglas Levinson; Fiscal Year: 2002
    ..These studies may assist investigators in determining which candidate regions are most deserving of intensive efforts to find disease-related genes, and the most likely locations of these genes within the regions. ..
  51. Multicenter Genetics Studies of Schizophrenia
    Douglas Levinson; Fiscal Year: 2006
    ....
  52. MOLECULAR GENETICS OF SCHIZOPHRENIA
    Douglas Levinson; Fiscal Year: 2005
    ..The goal of the study is to identify one or more SZ susceptibility genes whose subsequent characterization inmolecular and functional studies will elucidate the pathophysiology and treatment of SZ. ..
  53. Multicenter Genetics Studies of Schizophrenia
    Douglas Levinson; Fiscal Year: 2004
    ....
  54. GENETICS OF RECURRENT EARLY-ONSET DEPRESSION
    Douglas Levinson; Fiscal Year: 1999
    ..A timetable is proposed for rapid sharing of all biological materials, blinded clinical data, genotypes and linkage analyses with the scientific community through the NIMH-sponsored Center for Genetic Studies. ..
  55. MOLECULAR GENETICS OF SCHIZOPHRENIA
    Douglas Levinson; Fiscal Year: 2006
    ..The goal of the study is to identify one or more SZ susceptibility genes whose subsequent characterization inmolecular and functional studies will elucidate the pathophysiology and treatment of SZ. ..
  56. Genetics of Early-Onset Depression
    Douglas Levinson; Fiscal Year: 2006
    ..abstract_text> ..
  57. MOLECULAR GENETICS OF SCHIZOPHRENIA
    Douglas Levinson; Fiscal Year: 2003
    ..The goal of the study is to identify one or more SZ susceptibility genes whose subsequent characterization inmolecular and functional studies will elucidate the pathophysiology and treatment of SZ. ..
  58. GENETICS OF RECURRENT EARLY-ONSET DEPRESSION
    Douglas Levinson; Fiscal Year: 2002
    ..A timetable is proposed for rapid sharing of all biological materials, blinded clinical data, genotypes and linkage analyses with the scientific community through the NIMH-sponsored Center for Genetic Studies. ..
  59. MOLECULAR GENETICS OF SCHIZOPHRENIA
    Douglas Levinson; Fiscal Year: 2005
    ..The goal of the study is to identify one or more SZ susceptibility genes whose subsequent characterization inmolecular and functional studies will elucidate the pathophysiology and treatment of SZ. ..
  60. MOLECULAR GENETICS OF SCHIZOPHRENIA
    Douglas Levinson; Fiscal Year: 2000
    ..Power analyses suggest that this study would have excellent power to detect loci associated with lambda sibs of 1.4, and moderate power for a value of 1.3, i.e., loci with relatively small etiologic effects. ..
  61. MOLECULAR GENETICS OF SCHIZOPHRENIA
    Douglas Levinson; Fiscal Year: 2007
    ..The goal of the study is to identify one or more SZ susceptibility genes whose subsequent characterization inmolecular and functional studies will elucidate the pathophysiology and treatment of SZ. ..