EXO1

Summary

Gene Symbol: EXO1
Description: exonuclease 1
Alias: HEX1, hExoI, exonuclease 1, rad2 nuclease family member, homolog of S. cerevisiae exonuclease 1
Species: human
Products:     EXO1

Top Publications

  1. Sun X, Zheng L, Shen B. Functional alterations of human exonuclease 1 mutants identified in atypical hereditary nonpolyposis colorectal cancer syndrome. Cancer Res. 2002;62:6026-30 pubmed
    ..Human exonuclease 1 (hExo1) possesses both 5'exonuclease and flap endonuclease activities and plays a role in DNA repair, ..
  2. Doherty K, Sharma S, Uzdilla L, Wilson T, Cui S, Vindigni A, et al. RECQ1 helicase interacts with human mismatch repair factors that regulate genetic recombination. J Biol Chem. 2005;280:28085-94 pubmed
    ..Importantly, RECQ1 stimulates the incision activity of human exonuclease 1 and the mismatch repair recognition complex MSH2/6 stimulates RECQ1 helicase activity...
  3. Schaetzlein S, Chahwan R, Avdievich E, Roa S, Wei K, Eoff R, et al. Mammalian Exo1 encodes both structural and catalytic functions that play distinct roles in essential biological processes. Proc Natl Acad Sci U S A. 2013;110:E2470-9 pubmed publisher
    Mammalian Exonuclease 1 (EXO1) is an evolutionarily conserved, multifunctional exonuclease involved in DNA damage repair, replication, immunoglobulin diversity, meiosis, and telomere maintenance...
  4. Yamamoto H, Hanafusa H, Ouchida M, Yano M, Suzuki H, Murakami M, et al. Single nucleotide polymorphisms in the EXO1 gene and risk of colorectal cancer in a Japanese population. Carcinogenesis. 2005;26:411-6 pubmed
    b>EXO1 is a member of the RAD2 nuclease family and functions in DNA replication, repair and recombination...
  5. Sharma S, Sommers J, Driscoll H, Uzdilla L, Wilson T, Brosh R. The exonucleolytic and endonucleolytic cleavage activities of human exonuclease 1 are stimulated by an interaction with the carboxyl-terminal region of the Werner syndrome protein. J Biol Chem. 2003;278:23487-96 pubmed
    b>Exonuclease 1 (EXO-1), a member of the RAD2 family of nucleases, has recently been proposed to function in the genetic pathways of DNA recombination, repair, and replication which are important for genome integrity...
  6. Wu Y, Berends M, Post J, Mensink R, Verlind E, van Der Sluis T, et al. Germline mutations of EXO1 gene in patients with hereditary nonpolyposis colorectal cancer (HNPCC) and atypical HNPCC forms. Gastroenterology. 2001;120:1580-7 pubmed
    ..The recently cloned EXO1 gene might be involved in the pathogenesis of HNPCC because the EXO1 protein strongly interacts with the MSH2 ..
  7. Lee Bi B, Nguyen L, Barsky D, Fernandes M, Wilson D. Molecular interactions of human Exo1 with DNA. Nucleic Acids Res. 2002;30:942-9 pubmed
    Human Exo1 is a member of the RAD2 nuclease family with roles in replication, repair and recombination...
  8. Nimonkar A, Ozsoy A, Genschel J, Modrich P, Kowalczykowski S. Human exonuclease 1 and BLM helicase interact to resect DNA and initiate DNA repair. Proc Natl Acad Sci U S A. 2008;105:16906-11 pubmed publisher
    ..establish that human BLM helicase, a member of the RecQ family, stimulates the nucleolytic activity of human exonuclease 1 (hExo1), a 5'-->3' double-stranded DNA exonuclease...
  9. Schmutte C, Marinescu R, Sadoff M, Guerrette S, Overhauser J, Fishel R. Human exonuclease I interacts with the mismatch repair protein hMSH2. Cancer Res. 1998;58:4537-42 pubmed
    ..Here, we report on a novel human exonuclease (hExoI) that is related to the yeast exonuclease 1. The hExoI cDNA comprises 2541 bp, which code for a Mr 94,000 protein that appears to be highly expressed in ..

More Information

Publications82

  1. Alam N, Gorman P, Jaeger E, Kelsell D, Leigh I, Ratnavel R, et al. Germline deletions of EXO1 do not cause colorectal tumors and lesions which are null for EXO1 do not have microsatellite instability. Cancer Genet Cytogenet. 2003;147:121-7 pubmed
    b>Exonuclease 1 (EXO1) is a candidate gene for colorectal tumor susceptibility because it is believed to play a role in mismatch repair...
  2. Rasmussen L, Rasmussen M, Lee B, Rasmussen A, Wilson D, Nielsen F, et al. Identification of factors interacting with hMSH2 in the fetal liver utilizing the yeast two-hybrid system. In vivo interaction through the C-terminal domains of hEXO1 and hMSH2 and comparative expression analysis. Mutat Res. 2000;460:41-52 pubmed
    ..We demonstrate that hMSH2 interacts with a human 5'-3' exonuclease 1 (hEXO1/HEX1) and that this interaction is mediated through their C-terminal domains...
  3. Tishkoff D, Amin N, Viars C, Arden K, Kolodner R. Identification of a human gene encoding a homologue of Saccharomyces cerevisiae EXO1, an exonuclease implicated in mismatch repair and recombination. Cancer Res. 1998;58:5027-31 pubmed
    The EXO1 gene was identified in Saccharomyces cerevisiae as a gene encoding an exonuclease that interacts with MSH2 and functions in mismatch repair and genetic recombination...
  4. Nebel A, Flachsbart F, Till A, Caliebe A, Blanche H, Arlt A, et al. A functional EXO1 promoter variant is associated with prolonged life expectancy in centenarians. Mech Ageing Dev. 2009;130:691-9 pubmed publisher
    ..The obtained association signal in exonuclease 1 (EXO1) was further investigated by fine mapping and mutation detection, leading to the identification of the ..
  5. Vallur A, Maizels N. Activities of human exonuclease 1 that promote cleavage of transcribed immunoglobulin switch regions. Proc Natl Acad Sci U S A. 2008;105:16508-12 pubmed publisher
    Eukaryotic exonuclease 1 functions in replication, recombination, mismatch repair, telomere maintenance, immunoglobulin (Ig) gene class switch recombination, and somatic hypermutation...
  6. El Shemerly M, Hess D, Pyakurel A, Moselhy S, Ferrari S. ATR-dependent pathways control hEXO1 stability in response to stalled forks. Nucleic Acids Res. 2008;36:511-9 pubmed
    Nucleases play important roles in DNA synthesis, recombination and repair. We have previously shown that human exonuclease 1 (hEXO1) is phosphorylated in response to agents stalling DNA replication and that hEXO1 consequently undergoes ..
  7. Nimonkar A, Genschel J, Kinoshita E, Polaczek P, Campbell J, Wyman C, et al. BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair. Genes Dev. 2011;25:350-62 pubmed publisher
    ..reconstituted DNA end resection using purified human proteins: Bloom helicase (BLM); DNA2 helicase/nuclease; Exonuclease 1 (EXO1); the complex comprising MRE11, RAD50, and NBS1 (MRN); and Replication protein A (RPA)...
  8. Zhang Y, Yuan F, Presnell S, Tian K, Gao Y, Tomkinson A, et al. Reconstitution of 5'-directed human mismatch repair in a purified system. Cell. 2005;122:693-705 pubmed
    ..The reconstituted system includes MutSalpha or MutSbeta, MutLalpha, RPA, EXO1, HMGB1, PCNA, RFC, polymerase delta, and ligase I...
  9. Nielsen F, Jäger A, Lützen A, Bundgaard J, Rasmussen L. Characterization of human exonuclease 1 in complex with mismatch repair proteins, subcellular localization and association with PCNA. Oncogene. 2004;23:1457-68 pubmed
    Human exonuclease 1 (hEXO1) has been implicated in DNA mismatch repair (MMR), replication, and recombination, but the nature of its interaction with these cellular processes is still ambiguous...
  10. Dherin C, Gueneau E, Francin M, Nunez M, Miron S, Liberti S, et al. Characterization of a highly conserved binding site of Mlh1 required for exonuclease I-dependent mismatch repair. Mol Cell Biol. 2009;29:907-18 pubmed publisher
    ..In this study, we identified the site of yeast Mlh1 critical for the interaction with Exo1, Ntg2, and Sgs1 proteins, designated as site S2 by reference to the Mlh1/Pms1 heterodimerization site S1...
  11. Orans J, McSweeney E, Iyer R, Hast M, Hellinga H, Modrich P, et al. Structures of human exonuclease 1 DNA complexes suggest a unified mechanism for nuclease family. Cell. 2011;145:212-23 pubmed publisher
    Human exonuclease 1 (hExo1) plays important roles in DNA repair and recombination processes that maintain genomic integrity...
  12. Bolderson E, Tomimatsu N, Richard D, Boucher D, Kumar R, Pandita T, et al. Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks. Nucleic Acids Res. 2010;38:1821-31 pubmed publisher
    ..Here, we show that human Exonuclease 1 (Exo1) is required for the normal repair of DSBs by HR...
  13. Wilson D, Carney J, Coleman M, Adamson A, Christensen M, Lamerdin J. Hex1: a new human Rad2 nuclease family member with homology to yeast exonuclease 1. Nucleic Acids Res. 1998;26:3762-8 pubmed
    ..its homology to this and other DNA repair proteins of the Rad2 family, most notably Schizosaccharomyces pombe exonuclease 1 (Exo1), Hex1 presumably functions as a nuclease in aspects of recombination or mismatch repair...
  14. Jagmohan Changur S, Poikonen T, Vilkki S, Launonen V, Wikman F, Orntoft T, et al. EXO1 variants occur commonly in normal population: evidence against a role in hereditary nonpolyposis colorectal cancer. Cancer Res. 2003;63:154-8 pubmed
    ..Recently, mutations in the DNA repair gene EXO1 have been implicated in HNPCC...
  15. Knudsen N, Nielsen F, Vinther L, Bertelsen R, Holten Andersen S, Liberti S, et al. Nuclear localization of human DNA mismatch repair protein exonuclease 1 (hEXO1). Nucleic Acids Res. 2007;35:2609-19 pubmed
    Human exonuclease 1 (hEXO1) is implicated in DNA mismatch repair (MMR) and mutations in hEXO1 may be associated with hereditary nonpolyposis colorectal cancer (HNPCC)...
  16. Qiu J, Qian Y, Chen V, Guan M, Shen B. Human exonuclease 1 functionally complements its yeast homologues in DNA recombination, RNA primer removal, and mutation avoidance. J Biol Chem. 1999;274:17893-900 pubmed
    Yeast exonuclease 1 (Exo1) is induced during meiosis and plays an important role in DNA homologous recombination and mismatch correction pathways. The human homolog, an 803-amino acid protein, shares 55% similarity to the yeast Exo1...
  17. Genschel J, Modrich P. Mechanism of 5'-directed excision in human mismatch repair. Mol Cell. 2003;12:1077-86 pubmed
    ..As observed in the purified system, excision directed by a 5' strand break in HeLa nuclear extract can proceed in the absence of MutLalpha or PCNA, although 3' excision in the extract system requires both proteins. ..
  18. Lee B, Wilson D. The RAD2 domain of human exonuclease 1 exhibits 5' to 3' exonuclease and flap structure-specific endonuclease activities. J Biol Chem. 1999;274:37763-9 pubmed
    ..We report here that the RAD2 domain of human exonuclease 1 (HEX1-N2) exhibits both a robust 5' to 3' exonuclease activity on single- and double-stranded DNA substrates ..
  19. Eid W, Steger M, El Shemerly M, Ferretti L, Pena Diaz J, König C, et al. DNA end resection by CtIP and exonuclease 1 prevents genomic instability. EMBO Rep. 2010;11:962-8 pubmed publisher
    ..MRE11-RAD50-NBS1 (MRN) and CtIP, followed by a processive step involving helicases and exonucleases such as exonuclease 1 (EXO1). In this study, we show that the localization of EXO1 to DSBs depends on both CtIP and MRN...
  20. Dzantiev L, Constantin N, Genschel J, Iyer R, Burgers P, Modrich P. A defined human system that supports bidirectional mismatch-provoked excision. Mol Cell. 2004;15:31-41 pubmed
    ..By contrast, RFC and PCNA have only a limited effect on 5' to 3' excision directed by a 5' strand break. ..
  21. Tomimatsu N, Mukherjee B, Deland K, Kurimasa A, Bolderson E, Khanna K, et al. Exo1 plays a major role in DNA end resection in humans and influences double-strand break repair and damage signaling decisions. DNA Repair (Amst). 2012;11:441-8 pubmed publisher
    ..in yeast, initial resection by Mre11-CtIP is followed by extensive resection by two distinct pathways involving Exo1 or BLM/WRN-Dna2...
  22. Andersen S, Keijzers G, Rampakakis E, Engels K, Luhn P, El Shemerly M, et al. 14-3-3 checkpoint regulatory proteins interact specifically with DNA repair protein human exonuclease 1 (hEXO1) via a semi-conserved motif. DNA Repair (Amst). 2012;11:267-77 pubmed publisher
    Human exonuclease 1 (hEXO1) acts directly in diverse DNA processing events, including replication, mismatch repair (MMR), and double strand break repair (DSBR), and it was also recently described to function as damage sensor and ..
  23. Jäger A, Rasmussen M, Bisgaard H, Singh K, Nielsen F, Rasmussen L. HNPCC mutations in the human DNA mismatch repair gene hMLH1 influence assembly of hMutLalpha and hMLH1-hEXO1 complexes. Oncogene. 2001;20:3590-5 pubmed
    ..MMR proteins have been reported to associate with several proteins, including the human exonuclease 1 (hEXO1). We report here novel HNPCC-hMLH1 mutant proteins (T117M, Q426X and 1813insA) in Danish HNPCC patients...
  24. Liberti S, Rasmussen L. Is hEXO1 a cancer predisposing gene?. Mol Cancer Res. 2004;2:427-32 pubmed
  25. Schmutte C, Sadoff M, Shim K, Acharya S, Fishel R. The interaction of DNA mismatch repair proteins with human exonuclease I. J Biol Chem. 2001;276:33011-8 pubmed
    ..Human exonuclease I (hExoI) is a member of a family of conserved 5' --> 3' exonucleases, which are implicated in these processes by ..
  26. Genschel J, Bazemore L, Modrich P. Human exonuclease I is required for 5' and 3' mismatch repair. J Biol Chem. 2002;277:13302-11 pubmed
    ..co-purifies with the excision activity, and the purified activity can be replaced by near homogeneous recombinant hEXOI. Despite the reported 5' to 3' hydrolytic polarity of this activity, hEXOI participates in mismatch-provoked ..
  27. Pizzolato J, Mukherjee S, Schärer O, Jiricny J. FANCD2-associated nuclease 1, but not exonuclease 1 or flap endonuclease 1, is able to unhook DNA interstrand cross-links in vitro. J Biol Chem. 2015;290:22602-11 pubmed publisher
    ..Here we investigated how the 5' flap nucleases FANCD2-associated nuclease 1 (FAN1), exonuclease 1 (EXO1), and flap endonuclease 1 (FEN1) process a substrate reminiscent of a replication fork arrested at an ..
  28. Liao S, Tammaro M, Yan H. Enriching CRISPR-Cas9 targeted cells by co-targeting the HPRT gene. Nucleic Acids Res. 2015;43:e134 pubmed publisher
    ..Alterations of many genes, such as AAVS1, Exo1 and Trex1, are highly enriched in the 6-TG resistant cells...
  29. Chen X, Kim I, Honaker Y, Paudyal S, Koh W, Sparks M, et al. 14-3-3 proteins restrain the Exo1 nuclease to prevent overresection. J Biol Chem. 2015;290:12300-12 pubmed publisher
    ..Here we show that the major resection nuclease Exo1 is regulated both positively and negatively by protein-protein interactions to ensure a proper level of DNA ..
  30. Palermo V, Rinalducci S, Sanchez M, Grillini F, Sommers J, Brosh R, et al. CDK1 phosphorylates WRN at collapsed replication forks. Nat Commun. 2016;7:12880 pubmed publisher
    ..WRN participates in one of the two alternative long-range resection pathways mediated by DNA2 or EXO1. Here we demonstrate that phosphorylation of WRN by CDK1 is essential to perform DNA2-dependent end resection at ..
  31. Tomimatsu N, Mukherjee B, Harris J, Boffo F, Hardebeck M, Potts P, et al. DNA-damage-induced degradation of EXO1 exonuclease limits DNA end resection to ensure accurate DNA repair. J Biol Chem. 2017;292:10779-10790 pubmed publisher
    ..Activation of DNA end resection involves phosphorylation of the 5' to 3' exonuclease EXO1 by the phosphoinositide 3-kinase-like kinases ATM (ataxia telangiectasia-mutated) and ATR (ATM and Rad3-related) ..
  32. Bau D, Wang H, Liu C, Chang C, Chiang S, Wang R, et al. Single-nucleotide polymorphism of the Exo1 gene: association with gastric cancer susceptibility and interaction with smoking in Taiwan. Chin J Physiol. 2009;52:411-8 pubmed
    b>Exonuclease 1 (Exo1) is an important nuclease involved in the mismatch repair system that contributes to the maintenance of genomic stability, modulation of DNA recombination and mediation of cell cycle arrest...
  33. Colosio A, Frattini C, Pellicanò G, Villa Hernández S, Bermejo R. Nucleolytic processing of aberrant replication intermediates by an Exo1-Dna2-Sae2 axis counteracts fork collapse-driven chromosome instability. Nucleic Acids Res. 2016;44:10676-10690 pubmed
    ..This revealed a novel role for Exo1 nuclease in resecting reversed replication fork structures and counteracting the accumulation of aberrant ..
  34. Ait Saada A, Teixeira Silva A, Iraqui I, Costes A, Hardy J, Paoletti G, et al. Unprotected Replication Forks Are Converted into Mitotic Sister Chromatid Bridges. Mol Cell. 2017;66:398-410.e4 pubmed publisher
    ..activity of Rad51, but not its strand-exchange activity, act to protect terminally arrested forks from unrestrained Exo1-nucleolytic activity...
  35. Bayram S, Akkiz H, Bekar A, Akgöllü E, Yildirim S. No association of the exonuclease 1 T439M polymorphism and risk of hepatocellular carcinoma development in the Turkish population: a case-control study. Asian Pac J Cancer Prev. 2011;12:2455-60 pubmed
    b>Exonuclease 1 (Exo 1) is an important nuclease involved in the mismatch repair system that contributes to maintaining genomic stability, modulating DNA recombination and mediating cell cycle arrest...
  36. Lukaszewicz A, Shodhan A, Loidl J. Exo1 and Mre11 execute meiotic DSB end resection in the protist Tetrahymena. DNA Repair (Amst). 2015;35:137-43 pubmed publisher
    ..In mitosis, Exo1 and Sgs1 have a conserved function in the formation of long ssDNA tails, whereas this step in the processing of ..
  37. Myler L, Gallardo I, Soniat M, Deshpande R, Gonzalez X, Kim Y, et al. Single-Molecule Imaging Reveals How Mre11-Rad50-Nbs1 Initiates DNA Break Repair. Mol Cell. 2017;67:891-898.e4 pubmed publisher
    ..Next, MRN loads exonuclease 1 (Exo1) onto the free DNA ends to initiate DNA resection...
  38. Zhu H, Li X, Zhang X, Chen D, Li D, Ren J, et al. Polymorphisms in mismatch repair genes are associated with risk and microsatellite instability of gastric cancer, and interact with life exposures. Gene. 2016;579:52-7 pubmed publisher
    ..potentially functional polymorphisms were selected and analyzed: rs1800734 in MLH1, rs2303428 in MSH2, rs735943 in EXO1, and rs11797 in TREX1. The rs1800734 G-allele was associated with decreased risk of GC (GA or GG vs AA, OR=0...
  39. Tomimatsu N, Mukherjee B, Catherine Hardebeck M, Ilcheva M, Vanessa Camacho C, Louise Harris J, et al. Phosphorylation of EXO1 by CDKs 1 and 2 regulates DNA end resection and repair pathway choice. Nat Commun. 2014;5:3561 pubmed publisher
    ..Here we show that CDKs 1/2 phosphorylate the long-range resection nuclease EXO1 at four C-terminal S/TP sites during S/G2 phases of the cell cycle...
  40. Cheruiyot A, Paudyal S, Kim I, Sparks M, Ellenberger T, Piwnica Worms H, et al. Poly(ADP-ribose)-binding promotes Exo1 damage recruitment and suppresses its nuclease activities. DNA Repair (Amst). 2015;35:106-15 pubmed publisher
    b>Exonuclease 1 (Exo1) has important roles in DNA metabolic transactions that are essential for genome maintenance, telomere regulation and cancer suppression...
  41. Nogueira G, Lourenço G, Oliveira C, Marson F, Lopes Aguiar L, Costa E, et al. Association between genetic polymorphisms in DNA mismatch repair-related genes with risk and prognosis of head and neck squamous cell carcinoma. Int J Cancer. 2015;137:810-8 pubmed publisher
    We examined the influence of MLH1 c.-93G>A, MSH2 c.211 + 9C>G, MSH3 c.3133G>A and EXO1 c.1765G>A polymorphisms, involved in DNA mismatch repair (MMR), on head and neck (HN) squamous cell carcinoma (SCC) risk and prognosis...
  42. Swierczek K, Klimkowicz A, Nishihara K, Kobayashi S, Takasaki A, Alanizy M, et al. Oxygen storage properties of hexagonal HoMnO3+?. Phys Chem Chem Phys. 2017;19:19243-19251 pubmed publisher
    ..The oxygen storage properties during structural transformation between stoichiometric Hex0 and oxygen-loaded Hex1 phases, transition temperatures and kinetics of the oxygen incorporation and release are reported for materials ..
  43. Marin P, Da Silva M, Pavani R, Machado C, Elias M. Recruitment kinetics of the homologous recombination pathway in procyclic forms of Trypanosoma brucei after ionizing radiation treatment. Sci Rep. 2018;8:5405 pubmed publisher
    ..kinetics involved the phosphorylation of histone H2A and the sequential recruitment of the essential HR players Exo1, RPA, and Rad51. The process of DSB repair took approximately 5.5 hours...
  44. Lawrenson K, Iversen E, Tyrer J, Weber R, Concannon P, Hazelett D, et al. Common variants at the CHEK2 gene locus and risk of epithelial ovarian cancer. Carcinogenesis. 2015;36:1341-53 pubmed publisher
    ..We found evidence of associations with EOC risk for variants at FANCA, EXO1, E2F4, E2F2, CREB5 and CHEK2 genes (P ≤ 0.001)...
  45. Holstein E, Ngo G, Lawless C, Banks P, Greetham M, Wilkinson D, et al. Systematic Analysis of the DNA Damage Response Network in Telomere Defective Budding Yeast. G3 (Bethesda). 2017;7:2375-2389 pubmed publisher
    ..In more complex experiments, genetic interactions were measured in cells lacking EXO1 or RAD9, affecting different aspects of the DNA damage response, and containing a cdc13-1 induced ..
  46. Levikova M, Cejka P. The Saccharomyces cerevisiae Dna2 can function as a sole nuclease in the processing of Okazaki fragments in DNA replication. Nucleic Acids Res. 2015;43:7888-97 pubmed publisher
    ..We propose a model where Dna2 alone is responsible for cleaving of RPA-bound long flaps, while Fen1 or exonuclease 1 (Exo1) cleave short flaps...
  47. Brambati A, Zardoni L, Achar Y, Piccini D, Galanti L, Colosio A, et al. Dormant origins and fork protection mechanisms rescue sister forks arrested by transcription. Nucleic Acids Res. 2017;: pubmed publisher
    ..the Mre11 and Mrc1-Ctf4 complexes protect the forks arrested by transcription from processing mediated by the Exo1 nuclease...
  48. Kim J, Roh S, Yoon Y, Kim H, Park I. MLH3 and EXO1 alterations in familial colorectal cancer patients not fulfilling Amsterdam criteria. Cancer Genet Cytogenet. 2007;176:172-4 pubmed
  49. Sun J, Lee K, Davis A, Chen D. Human Ku70/80 protein blocks exonuclease 1-mediated DNA resection in the presence of human Mre11 or Mre11/Rad50 protein complex. J Biol Chem. 2012;287:4936-45 pubmed publisher
    ..end resection system using a forked model dsDNA substrate and purified human Ku70/80, Mre11, Mre11/Rad50, and exonuclease 1 (Exo1)...
  50. Keijzers G, Liu D, Rasmussen L. Exonuclease 1 and its versatile roles in DNA repair. Crit Rev Biochem Mol Biol. 2016;51:440-451 pubmed publisher
    b>Exonuclease 1 (EXO1) is a multifunctional 5' ? 3' exonuclease and a DNA structure-specific DNA endonuclease...
  51. Larsen N, Liberti S, Vogel I, Jørgensen S, Hickson I, Mankouri H. Stalled replication forks generate a distinct mutational signature in yeast. Proc Natl Acad Sci U S A. 2017;114:9665-9670 pubmed publisher
    ..alterations arise through the aberrant repair of a single-stranded DNA gap, in a process that is dependent on Exo1- and Shu1-dependent homologous recombination repair (HRR)...
  52. Shibata A. Regulation of repair pathway choice at two-ended DNA double-strand breaks. Mutat Res. 2017;803-805:51-55 pubmed publisher
    ..repositioning may be important for the establishment of a chromatin environment that promotes the recruitment of EXO1 for resection in HR...
  53. Izzotti A, Longobardi M, Cartiglia C, Anzuini F, Arrigo P, Fazzi E, et al. Different mutations in three prime repair exonuclease 1 and ribonuclease H2 genes affect clinical features in Aicardi-Goutieres syndrome. J Child Neurol. 2012;27:51-60 pubmed publisher
  54. Vallur A, Maizels N. Complementary roles for exonuclease 1 and Flap endonuclease 1 in maintenance of triplet repeats. J Biol Chem. 2010;285:28514-9 pubmed publisher
    ..have defined biochemical activities of the related RAD2 family nucleases, FEN1 (Flap endonuclease 1) and EXO1 (exonuclease 1), on substrates that recapitulate intermediates in DNA replication...
  55. Holle G. [Pathophysiology of ulcer disease]. Langenbecks Arch Chir. 1985;366:81-7 pubmed
    ..This surgical treatment should therefore have priority in the treatment also of uncomplicated duodenal ulcers and with some exceptions of GU. ..
  56. Worasilchai N, Permpalung N, Chindamporn A. High-resolution melting analysis: A novel approach for clade differentiation in Pythium insidiosum and pythiosis. Med Mycol. 2018;56:868-876 pubmed publisher
    ..mitochondrial cytochrome C oxidase II (COX2) gene, intergenic spacer (IGS) region and exo-1,3-β-glucanase gene (exo1), P. insidiosum is classified into clade ATH, BTH, and CTH related to geographic distribution...
  57. Kato N, Kawasoe Y, Williams H, Coates E, Roy U, Shi Y, et al. Sensing and Processing of DNA Interstrand Crosslinks by the Mismatch Repair Pathway. Cell Rep. 2017;21:1375-1385 pubmed publisher
    ..MutS? recruits MutL? and EXO1 to ICL lesions, and the catalytic activity of both these nucleases is essential for ICL repair...
  58. Shi T, Jiang R, Wang P, Xu Y, Yin S, Cheng X, et al. Significant association of the EXO1 rs851797 polymorphism with clinical outcome of ovarian cancer. Onco Targets Ther. 2017;10:4841-4851 pubmed publisher
    b>Exonuclease 1 (EXO1), one of DNA mismatch repair pathway genes, functions in maintaining genomic stability and affects tumor progression...
  59. Shaw S, Finger L, Grasby J. Human Exonuclease 1 Threads 5'-Flap Substrates through Its Helical Arch. Biochemistry. 2017;56:3704-3707 pubmed publisher
    Human exonuclease 1 (hEXO1) is a member of the 5'-nuclease superfamily and plays important roles in DNA repair...
  60. Biehs R, Steinlage M, Barton O, Juhasz S, Künzel J, Spies J, et al. DNA Double-Strand Break Resection Occurs during Non-homologous End Joining in G1 but Is Distinct from Resection during Homologous Recombination. Mol Cell. 2017;65:671-684.e5 pubmed publisher
    ..Mre11 exonuclease, EXD2, and Exo1 execute resection, and Artemis endonuclease functions to complete the process...
  61. Kim H, Williamson E, Nickoloff J, Hromas R, Lee S. Metnase Mediates Loading of Exonuclease 1 onto Single Strand Overhang DNA for End Resection at Stalled Replication Forks. J Biol Chem. 2017;292:1414-1425 pubmed publisher
    ..In this study, we show that Metnase associates with exonuclease 1 (Exo1), a 5'-exonuclease crucial for 5'-end resection to mediate DNA processing at stalled forks...
  62. Matakidou A, El Galta R, Webb E, Rudd M, Bridle H, Eisen T, et al. Genetic variation in the DNA repair genes is predictive of outcome in lung cancer. Hum Mol Genet. 2007;16:2333-40 pubmed
    ..023), ERCC6 Q1413R (P = 0.025), POLE (P = 0.014) and base excision repair: APEX1 D148E (P = 0.028); EXO1 E670G (P = 0.007); POLB P242R (P = 0.018)...
  63. Oh H, Bodelon C, Palakal M, Chatterjee N, Sherman M, Linville L, et al. Ages at menarche- and menopause-related genetic variants in relation to terminal duct lobular unit involution in normal breast tissue. Breast Cancer Res Treat. 2016;158:341-50 pubmed publisher
    ..32; rs7606918: METAP1D; rs11668344: TMEM150B; rs1635501: EXO1) were associated in the consistent directions...
  64. Bayram S. The exonuclease 1 Glu589Lys gene polymorphism and cancer susceptibility: evidence based on a meta-analysis. Asian Pac J Cancer Prev. 2014;15:2571-6 pubmed
    Published studies on the association between the exonuclease 1 (EXO1) Glu589Lys polymorphism and cancer susceptibility have yielded conflicting results...
  65. Hsu N, Wang H, Wang C, Chiu C, Tseng H, Liang S, et al. Lung cancer susceptibility and genetic polymorphisms of Exo1 gene in Taiwan. Anticancer Res. 2009;29:725-30 pubmed
    To evaluate the association between the polymorphisms of the Exo1 gene and the risk of lung cancer in central Taiwan...
  66. Ribeiro T, Weiblen C, de Azevedo M, de Avila Botton S, Robe L, Pereira D, et al. Microevolutionary analyses of Pythium insidiosum isolates of Brazil and Thailand based on exo-1,3-?-glucanase gene. Infect Genet Evol. 2017;48:58-63 pubmed publisher
    ..are frequently related to host shifts, we decided here to use sequences from the exo-1,3-?-glucanase gene (exo1), which encodes an immunodominant protein putatively involved in cell wall remodeling, to investigate the ..
  67. Tan S, Qin R, Zhu X, Tan C, Song J, Qin L, et al. Associations between single-nucleotide polymorphisms of human exonuclease 1 and the risk of hepatocellular carcinoma. Oncotarget. 2016;7:87180-87193 pubmed publisher
    Human exonuclease 1 (hEXO1) is an important nuclease involved in mismatch repair system that contributes to maintain genomic stability and modulate DNA recombination...
  68. Kolb A, Gunn A, Lakin N. Redundancy between nucleases required for homologous recombination promotes PARP inhibitor resistance in the eukaryotic model organism Dictyostelium. Nucleic Acids Res. 2017;45:10056-10067 pubmed publisher
    ..Dictyostelium cells disrupted in exonuclease I, a critical factor for HR, are sensitive to PARPi. Deletion of exo1 prevents the accumulation of Rad51 in chromatin induced by PARPi, resulting in DNA damage being channelled through ..
  69. Smith C, Mendillo M, Bowen N, Hombauer H, Campbell C, Desai A, et al. Dominant mutations in S. cerevisiae PMS1 identify the Mlh1-Pms1 endonuclease active site and an exonuclease 1-independent mismatch repair pathway. PLoS Genet. 2013;9:e1003869 pubmed publisher
    ..dominant in wild-type cells, which surprisingly caused a strong MMR defect when present on low copy plasmids in an exo1? mutant...
  70. Zhang T, Tang J, Sun J, Yu C, Liu Z, Chen J. Hex1-related transcriptome of Trichoderma atroviride reveals expression patterns of ABC transporters associated with tolerance to dichlorvos. Biotechnol Lett. 2015;37:1421-9 pubmed publisher
    ..RNA-seq analysis of wild-type Trichoderma atroviride T23 and the hex1-deleted mutant under dichlorvos stress was designed to search for genes involved in the tolerance process...
  71. Song F, Qureshi A, Zhang J, Zhan J, Amos C, Lee J, et al. Exonuclease 1 (EXO1) gene variation and melanoma risk. DNA Repair (Amst). 2012;11:304-9 pubmed publisher
    ..001 were selected for in silico replication. One SNP was replicated: rs3902093 [A] in EXO1 promoter region (P(discovery)=6.6 × 10??, P(replication)=0.039, P(joint)=2.5 × 10??; OR(joint)=0.80, 95% CI: 0...
  72. Lemaçon D, Jackson J, Quinet A, Brickner J, Li S, Yazinski S, et al. MRE11 and EXO1 nucleases degrade reversed forks and elicit MUS81-dependent fork rescue in BRCA2-deficient cells. Nat Commun. 2017;8:860 pubmed publisher
    ..The CtIP protein initiates MRE11-dependent degradation, which is extended by the EXO1 nuclease...
  73. Zhou J, Wang Y, Wang Y, Yin X, He Y, Chen L, et al. FOXM1 modulates cisplatin sensitivity by regulating EXO1 in ovarian cancer. PLoS ONE. 2014;9:e96989 pubmed publisher
    ..FOXM1 facilitates DNA repair through regulating direct transcriptional target EXO1 to protect ovarian cancer cells from cisplatin-mediated apoptosis...