ETO

Summary

Gene Symbol: ETO
Description: RUNX1 translocation partner 1
Alias: AML1-MTG8, AML1T1, CBFA2T1, CDR, ETO, MTG8, ZMYND2, protein CBFA2T1, acute myelogenous leukemia 1 translocation 1, cyclin-D related, core-binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclin D-related, eight twenty one protein, myeloid translocation gene on 8q22, runt related transcription factor 1; translocated to, 1 (cyclin D related), zinc finger MYND domain-containing protein 2
Species: human
Products:     ETO

Top Publications

  1. Lindberg S, Olsson A, Persson A, Olsson I. The Leukemia-associated ETO homologues are differently expressed during hematopoietic differentiation. Exp Hematol. 2005;33:189-98 pubmed
    The Eight twenty-one (ETO) homologues are nuclear repressor proteins including ETO, myeloid-transforming gene-related protein 1 (MTGR1), and myeloid-transforming gene chromosome 16 (MTG16)...
  2. Chevallier N, Corcoran C, Lennon C, Hyjek E, Chadburn A, Bardwell V, et al. ETO protein of t(8;21) AML is a corepressor for Bcl-6 B-cell lymphoma oncoprotein. Blood. 2004;103:1454-63 pubmed
    ..The ETO protein of t(8;21) acute myeloid leukemia (AML) is an excellent candidate as a common factor because it is normally ..
  3. McGhee L, Bryan J, Elliott L, Grimes H, Kazanjian A, Davis J, et al. Gfi-1 attaches to the nuclear matrix, associates with ETO (MTG8) and histone deacetylase proteins, and represses transcription using a TSA-sensitive mechanism. J Cell Biochem. 2003;89:1005-18 pubmed
    ..ETO (also termed MTG8), was first identified through its involvement in the (8;21) translocation associated with acute myelogenous ..
  4. Lindberg S, Olsson A, Persson A, Olsson I. Interactions between the leukaemia-associated ETO homologues of nuclear repressor proteins. Eur J Haematol. 2003;71:439-47 pubmed
    The eight-twenty-one (ETO) homologues, represented by ETO, myeloid transforming gene-related protein 1 (MTGR1) and myeloid transforming gene chromosome 16 (MTG16), are nuclear repressor proteins...
  5. Martinez N, Drescher B, Riehle H, Cullmann C, Vornlocher H, Ganser A, et al. The oncogenic fusion protein RUNX1-CBFA2T1 supports proliferation and inhibits senescence in t(8;21)-positive leukaemic cells. BMC Cancer. 2004;4:44 pubmed
    The fusion protein RUNX1-CBFA2T1 associated with t(8;21)-positive acute myeloid leukaemia is a potent inhibitor of haematopoetic differentiation. The role of RUNX1-CBFA2T1 in leukaemic cell proliferation is less clear...
  6. Lausen J, Cho S, Liu S, Werner M. The nuclear receptor co-repressor (N-CoR) utilizes repression domains I and III for interaction and co-repression with ETO. J Biol Chem. 2004;279:49281-8 pubmed
    ..The t(8;21) translocation gene product led to the discovery of the Eight Twenty-One (ETO) gene...
  7. Hildebrand D, Tiefenbach J, Heinzel T, Grez M, Maurer A. Multiple regions of ETO cooperate in transcriptional repression. J Biol Chem. 2001;276:9889-95 pubmed
    ..leukemias (AMLs) with t(8;21), the transcription factor AML1 is juxtaposed to the zinc finger nuclear protein ETO (Eight-Twenty-One), resulting in transcriptional repression of AML1 target genes...
  8. Wildonger J, Mann R. The t(8;21) translocation converts AML1 into a constitutive transcriptional repressor. Development. 2005;132:2263-72 pubmed
    ..Two genes, AML1 and ETO, are fused together at the translocation breakpoint, resulting in the expression of a chimeric protein called AML1-..
  9. Erickson P, Gao J, Chang K, Look T, Whisenant E, Raimondi S, et al. Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt. Blood. 1992;80:1825-31 pubmed
    ..The chromosome 8 component, referred to as ETO (for eight twenty-one), is encoded over a large genomic region, as suggested by the analysis of corresponding yeast ..
  10. Wichmann C, Becker Y, Chen Wichmann L, Vogel V, Vojtkova A, Herglotz J, et al. Dimer-tetramer transition controls RUNX1/ETO leukemogenic activity. Blood. 2010;116:603-13 pubmed publisher
    RUNX1/ETO, the fusion protein resulting from the chromosomal translocation t(8;21), is one of the most frequent translocation products in acute myeloid leukemia...

Detail Information

Publications78

  1. Lindberg S, Olsson A, Persson A, Olsson I. The Leukemia-associated ETO homologues are differently expressed during hematopoietic differentiation. Exp Hematol. 2005;33:189-98 pubmed
    The Eight twenty-one (ETO) homologues are nuclear repressor proteins including ETO, myeloid-transforming gene-related protein 1 (MTGR1), and myeloid-transforming gene chromosome 16 (MTG16)...
  2. Chevallier N, Corcoran C, Lennon C, Hyjek E, Chadburn A, Bardwell V, et al. ETO protein of t(8;21) AML is a corepressor for Bcl-6 B-cell lymphoma oncoprotein. Blood. 2004;103:1454-63 pubmed
    ..The ETO protein of t(8;21) acute myeloid leukemia (AML) is an excellent candidate as a common factor because it is normally ..
  3. McGhee L, Bryan J, Elliott L, Grimes H, Kazanjian A, Davis J, et al. Gfi-1 attaches to the nuclear matrix, associates with ETO (MTG8) and histone deacetylase proteins, and represses transcription using a TSA-sensitive mechanism. J Cell Biochem. 2003;89:1005-18 pubmed
    ..ETO (also termed MTG8), was first identified through its involvement in the (8;21) translocation associated with acute myelogenous ..
  4. Lindberg S, Olsson A, Persson A, Olsson I. Interactions between the leukaemia-associated ETO homologues of nuclear repressor proteins. Eur J Haematol. 2003;71:439-47 pubmed
    The eight-twenty-one (ETO) homologues, represented by ETO, myeloid transforming gene-related protein 1 (MTGR1) and myeloid transforming gene chromosome 16 (MTG16), are nuclear repressor proteins...
  5. Martinez N, Drescher B, Riehle H, Cullmann C, Vornlocher H, Ganser A, et al. The oncogenic fusion protein RUNX1-CBFA2T1 supports proliferation and inhibits senescence in t(8;21)-positive leukaemic cells. BMC Cancer. 2004;4:44 pubmed
    The fusion protein RUNX1-CBFA2T1 associated with t(8;21)-positive acute myeloid leukaemia is a potent inhibitor of haematopoetic differentiation. The role of RUNX1-CBFA2T1 in leukaemic cell proliferation is less clear...
  6. Lausen J, Cho S, Liu S, Werner M. The nuclear receptor co-repressor (N-CoR) utilizes repression domains I and III for interaction and co-repression with ETO. J Biol Chem. 2004;279:49281-8 pubmed
    ..The t(8;21) translocation gene product led to the discovery of the Eight Twenty-One (ETO) gene...
  7. Hildebrand D, Tiefenbach J, Heinzel T, Grez M, Maurer A. Multiple regions of ETO cooperate in transcriptional repression. J Biol Chem. 2001;276:9889-95 pubmed
    ..leukemias (AMLs) with t(8;21), the transcription factor AML1 is juxtaposed to the zinc finger nuclear protein ETO (Eight-Twenty-One), resulting in transcriptional repression of AML1 target genes...
  8. Wildonger J, Mann R. The t(8;21) translocation converts AML1 into a constitutive transcriptional repressor. Development. 2005;132:2263-72 pubmed
    ..Two genes, AML1 and ETO, are fused together at the translocation breakpoint, resulting in the expression of a chimeric protein called AML1-..
  9. Erickson P, Gao J, Chang K, Look T, Whisenant E, Raimondi S, et al. Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt. Blood. 1992;80:1825-31 pubmed
    ..The chromosome 8 component, referred to as ETO (for eight twenty-one), is encoded over a large genomic region, as suggested by the analysis of corresponding yeast ..
  10. Wichmann C, Becker Y, Chen Wichmann L, Vogel V, Vojtkova A, Herglotz J, et al. Dimer-tetramer transition controls RUNX1/ETO leukemogenic activity. Blood. 2010;116:603-13 pubmed publisher
    RUNX1/ETO, the fusion protein resulting from the chromosomal translocation t(8;21), is one of the most frequent translocation products in acute myeloid leukemia...
  11. Peterson L, Yan M, Zhang D. The p21Waf1 pathway is involved in blocking leukemogenesis by the t(8;21) fusion protein AML1-ETO. Blood. 2007;109:4392-8 pubmed
    ..Multiple mouse models using this fusion protein demonstrate that AML1-ETO requires secondary mutagenic events to promote leukemogenesis...
  12. Lu Y, Peng Z, Yuan T, Yin Q, Xia L, Chen G. Multi-sites cleavage of leukemogenic AML1-ETO fusion protein by caspase-3 and its contribution to increased apoptotic sensitivity. Leukemia. 2008;22:378-86 pubmed
    Leukemia-associated fusion protein AML1-ETO is a product of the chromosome translocation (8;21) frequently occurred in acute myeloid leukemia (AML)...
  13. Li Y, Gao L, Luo X, Wang L, Gao X, Wang W, et al. Epigenetic silencing of microRNA-193a contributes to leukemogenesis in t(8;21) acute myeloid leukemia by activating the PTEN/PI3K signal pathway. Blood. 2013;121:499-509 pubmed publisher
    ..The biologic and clinical significance of microRNA dysregulation associated with AML1/ETO expressed in t(8;21) AML is unknown...
  14. Amann J, Chyla B, Ellis T, Martinez A, Moore A, Franklin J, et al. Mtgr1 is a transcriptional corepressor that is required for maintenance of the secretory cell lineage in the small intestine. Mol Cell Biol. 2005;25:9576-85 pubmed
    Two members of the MTG/ETO family of transcriptional corepressors, MTG8 and MTG16, are disrupted by chromosomal translocations in up to 15% of acute myeloid leukemia cases...
  15. Morohoshi F, Mitani S, Mitsuhashi N, Kitabayashi I, Takahashi E, Suzuki M, et al. Structure and expression pattern of a human MTG8/ETO family gene, MTGR1. Gene. 2000;241:287-95 pubmed
    AML1-MTG8 fusion protein, which is produced from the rearranged gene formed between AML1 and MTG8 in myeloid leukemia with t(8;21) chromosomal translocation, plays an important role in the pathogenesis of leukemia...
  16. Zhang J, Hug B, Huang E, Chen C, Gelmetti V, Maccarana M, et al. Oligomerization of ETO is obligatory for corepressor interaction. Mol Cell Biol. 2001;21:156-63 pubmed
    ..translocation that combines a sequence-specific DNA binding protein, AML1, with a potent transcriptional repressor, ETO. ETO interacts with nuclear receptor corepressors SMRT and N-CoR, which recruit histone deacetylase to the AML1-ETO ..
  17. Amann J, Nip J, Strom D, Lutterbach B, Harada H, Lenny N, et al. ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain. Mol Cell Biol. 2001;21:6470-83 pubmed
    t(8;21) and t(16;21) create two fusion proteins, AML-1-ETO and AML-1-MTG16, respectively, which fuse the AML-1 DNA binding domain to putative transcriptional corepressors, ETO and MTG16...
  18. Chou F, Wunderlich M, Griesinger A, Mulloy J. N-Ras(G12D) induces features of stepwise transformation in preleukemic human umbilical cord blood cultures expressing the AML1-ETO fusion gene. Blood. 2011;117:2237-40 pubmed publisher
    AML1-ETO (AE) is a fusion product of t(8;21) observed in 40% French-American-British M2 type of acute myeloid leukemia (AML). Clinical data suggest that Ras mutation is a frequent cooperating event in t(8;21) AML...
  19. Wang L, Gural A, Sun X, Zhao X, Perna F, Huang G, et al. The leukemogenicity of AML1-ETO is dependent on site-specific lysine acetylation. Science. 2011;333:765-9 pubmed publisher
    ..We found that AML1-ETO, the fusion protein generated by the t(8;21) translocation, is acetylated by the transcriptional coactivator p300 ..
  20. Follows G, Tagoh H, Lefevre P, Hodge D, Morgan G, Bonifer C. Epigenetic consequences of AML1-ETO action at the human c-FMS locus. EMBO J. 2003;22:2798-809 pubmed
    ..In t(8;21) leukaemic cells expressing the aberrant fusion protein AML1-ETO, we demonstrate that this protein is part of a transcription factor complex binding to extended sequences of the c-..
  21. Gardini A, Cesaroni M, Luzi L, Okumura A, Biggs J, Minardi S, et al. AML1/ETO oncoprotein is directed to AML1 binding regions and co-localizes with AML1 and HEB on its targets. PLoS Genet. 2008;4:e1000275 pubmed publisher
    A reciprocal translocation involving chromosomes 8 and 21 generates the AML1/ETO oncogenic transcription factor that initiates acute myeloid leukemia by recruiting co-repressor complexes to DNA...
  22. Dhanda R, Lindberg S, Olsson I. The human SIN3B corepressor forms a nucleolar complex with leukemia-associated ETO homologues. BMC Mol Biol. 2008;9:8 pubmed publisher
    ..The purpose of this work was to study possible interactions between corepressors human SIN3B (hSIN3B) and the ETO homologues - ETO (eight twenty-one), MTG16 (myeloid-transforming gene 16) and MTGR1 (MTG-related protein 1)...
  23. Bakshi R, Zaidi S, Pande S, Hassan M, Young D, Montecino M, et al. The leukemogenic t(8;21) fusion protein AML1-ETO controls rRNA genes and associates with nucleolar-organizing regions at mitotic chromosomes. J Cell Sci. 2008;121:3981-90 pubmed publisher
    ..The t(8;21)-related AML1-ETO fusion protein blocks differentiation of myeloid progenitors...
  24. Barseguian K, Lutterbach B, Hiebert S, Nickerson J, Lian J, Stein J, et al. Multiple subnuclear targeting signals of the leukemia-related AML1/ETO and ETO repressor proteins. Proc Natl Acad Sci U S A. 2002;99:15434-9 pubmed
    ..t(8;21) that fuses the N-terminal part of the key hematopoietic regulatory factor AML1 (RUNX1) to the ETO (MTG8) repressor protein...
  25. Hoogeveen A, Rossetti S, Stoyanova V, Schonkeren J, Fenaroli A, Schiaffonati L, et al. The transcriptional corepressor MTG16a contains a novel nucleolar targeting sequence deranged in t (16; 21)-positive myeloid malignancies. Oncogene. 2002;21:6703-12 pubmed
    ..MTG16a, like MTG8, the nuclear corepressor deranged by the t (8; 21), is capable to interact with specific histone deacetylases (..
  26. Nagel S, Hambach L, Krauter J, Venturini L, Heidenreich O, Ganser A, et al. Analysis of the nuclear distribution of the translocation t(8;21)-derived fusion protein AML1/ETO by confocal laser scanning microscopy. J Hematother Stem Cell Res. 2002;11:401-8 pubmed
    The AML1/ETO protein derived from the t(8;21) translocation retains the DNA binding domain of AML1, the runt homology domain (RHD), and nearly the complete ETO protein with its four nervy homology regions (NHR1-4)...
  27. Melnick A, Carlile G, McConnell M, Polinger A, Hiebert S, Licht J. AML-1/ETO fusion protein is a dominant negative inhibitor of transcriptional repression by the promyelocytic leukemia zinc finger protein. Blood. 2000;96:3939-47 pubmed
    The AML-1/ETO fusion protein, created by the (8;21) translocation in M2-type acute myelogenous leukemia (AML), is a dominant repressive form of AML-1...
  28. Odaka Y, Mally A, Elliott L, Meyers S. Nuclear import and subnuclear localization of the proto-oncoprotein ETO (MTG8). Oncogene. 2000;19:3584-97 pubmed
    ETO (MTG8) was first described due to its involvement in the (8;21) translocation frequently observed in acute myeloid leukemias. In the t(8;21) the AML1 gene on chromosome 21 is fused to ETO on chromosome 8...
  29. Wolford J, Prochazka M. Structure and expression of the human MTG8/ETO gene. Gene. 1998;212:103-9 pubmed
    ..Identical alternatively spliced mRNA variants were found to be produced by the highly conserved homologous gene (Cbfa2t1) in the mouse, suggesting an evolutionary significance.
  30. Sacchi N, Tamanini F, Willemsen R, Denis Donini S, Campiglio S, Hoogeveen A. Subcellular localization of the oncoprotein MTG8 (CDR/ETO) in neural cells. Oncogene. 1998;16:2609-15 pubmed
    ..known as the core binding factor A2 (CBFA2) on chromosome 21, and a gene on chromosome 8, hereafter referred to as MTG8, but also known as CDR and ETO...
  31. Miyoshi H, Kozu T, Shimizu K, Enomoto K, Maseki N, Kaneko Y, et al. The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript. EMBO J. 1993;12:2715-21 pubmed
    ..Here we report that this translocation juxtaposes the AML1 gene with a novel gene, named MTG8, on chromosome 8, resulting in the synthesis of an AML1-MTG8 fusion transcript...
  32. Miyamoto T, Weissman I, Akashi K. AML1/ETO-expressing nonleukemic stem cells in acute myelogenous leukemia with 8;21 chromosomal translocation. Proc Natl Acad Sci U S A. 2000;97:7521-6 pubmed
    Leukemia-specific AML1/ETO transcripts are detectable in most patients with t(8;21) acute myelogenous leukemia (AML) in long-term remission...
  33. Dunne J, Cullmann C, Ritter M, Soria N, Drescher B, Debernardi S, et al. siRNA-mediated AML1/MTG8 depletion affects differentiation and proliferation-associated gene expression in t(8;21)-positive cell lines and primary AML blasts. Oncogene. 2006;25:6067-78 pubmed
    ..The resultant fusion protein AML1/MTG8 interferes with haematopoietic gene expression and is an important regulator of leukaemogenesis...
  34. Gelmetti V, Zhang J, Fanelli M, Minucci S, Pelicci P, Lazar M. Aberrant recruitment of the nuclear receptor corepressor-histone deacetylase complex by the acute myeloid leukemia fusion partner ETO. Mol Cell Biol. 1998;18:7185-91 pubmed
    ..We report here that ETO (eight-twenty-one or MTG8), which is fused to the acute myelogenous leukemia 1 (AML1) transcription factor in t(8;21) AML, interacts via its ..
  35. Fazi F, Zardo G, Gelmetti V, Travaglini L, Ciolfi A, Di Croce L, et al. Heterochromatic gene repression of the retinoic acid pathway in acute myeloid leukemia. Blood. 2007;109:4432-40 pubmed
    ..Here, we show that AML1/ETO, the most common translocation fusion product in acute myeloid leukemia (AML), counteracts the activity of retinoic ..
  36. Kozu T, Miyoshi H, Shimizu K, Maseki N, Kaneko Y, Asou H, et al. Junctions of the AML1/MTG8(ETO) fusion are constant in t(8;21) acute myeloid leukemia detected by reverse transcription polymerase chain reaction. Blood. 1993;82:1270-6 pubmed
    ..The analysis of the cDNAs structure has led to the identification of the fusion of AML1 with a gene named MTG8 on chromosome 8, which seems to be identical to ETO. Northern analysis using MTG8 (ETO) probes detected 7...
  37. Jiao B, Wu C, Liang Y, Chen H, Xiong S, Chen B, et al. AML1-ETO9a is correlated with C-KIT overexpression/mutations and indicates poor disease outcome in t(8;21) acute myeloid leukemia-M2. Leukemia. 2009;23:1598-604 pubmed publisher
    AML1-ETO fusion gene is generated from chromosomal translocation t(8;21) mainly in acute myeloid leukemia M2 subtype (AML-M2). Its spliced variant transcript, AML1-ETO9a, rapidly induces leukemia in murine model...
  38. Nisson P, Watkins P, Sacchi N. Transcriptionally active chimeric gene derived from the fusion of the AML1 gene and a novel gene on chromosome 8 in t(8;21) leukemic cells. Cancer Genet Cytogenet. 1992;63:81-8 pubmed
    ..of a chromosome 8 gene that contains a region of sequence homology with the cyclin D2 gene, here referred to as the CDR gene (cyclin D-related gene). The chimeric gene is probably responsible for the pathogenesis of the 8;21 AML...
  39. DeKelver R, Yan M, Ahn E, Shia W, Speck N, Zhang D. Attenuation of AML1-ETO cellular dysregulation correlates with increased leukemogenic potential. Blood. 2013;121:3714-7 pubmed publisher
    ..by the 8;21 translocation, commonly found in acute myeloid leukemia, which fuses the AML1 (RUNX1) and ETO (MTG8, RUNX1T1) genes...
  40. Ptasinska A, Assi S, Mannari D, James S, Williamson D, Dunne J, et al. Depletion of RUNX1/ETO in t(8;21) AML cells leads to genome-wide changes in chromatin structure and transcription factor binding. Leukemia. 2012;26:1829-41 pubmed publisher
    The t(8;21) translocation fuses the DNA-binding domain of the hematopoietic master regulator RUNX1 to the ETO protein...
  41. Moore A, Amann J, Williams C, Tahinci E, Farmer T, Martinez J, et al. Myeloid translocation gene family members associate with T-cell factors (TCFs) and influence TCF-dependent transcription. Mol Cell Biol. 2008;28:977-87 pubmed
    ..translocations in acute myeloid leukemia, whereas MTG16 may be inactivated in up to 40% of breast cancer and MTG8 is a candidate cancer gene in colorectal carcinoma...
  42. Yan M, Kanbe E, Peterson L, Boyapati A, Miao Y, Wang Y, et al. A previously unidentified alternatively spliced isoform of t(8;21) transcript promotes leukemogenesis. Nat Med. 2006;12:945-9 pubmed
    ..as AML1, CBFalpha2 or PEBP2alphaB), including its DNA binding domain, and almost the entire RUNX1T1 (also known as MTG8 or ETO) protein...
  43. Zhang J, Kalkum M, Yamamura S, Chait B, Roeder R. E protein silencing by the leukemogenic AML1-ETO fusion protein. Science. 2004;305:1286-9 pubmed
    The AML1-ETO fusion protein, generated by the t(8;21) chromosomal translocation, is causally involved in nearly 15% of acute myeloid leukemia (AML) cases...
  44. Puccetti E, Obradovic D, Beissert T, Bianchini A, Washburn B, Chiaradonna F, et al. AML-associated translocation products block vitamin D(3)-induced differentiation by sequestering the vitamin D(3) receptor. Cancer Res. 2002;62:7050-8 pubmed
    ..result in formation of chimeric transcription factors, such as PML/RARalpha, PLZF/RARalpha, and AML-1/ETO, of which the components are involved in regulation of transcription by chromatin modeling through histone ..
  45. Tonks A, Pearn L, Tonks A, Pearce L, Hoy T, Phillips S, et al. The AML1-ETO fusion gene promotes extensive self-renewal of human primary erythroid cells. Blood. 2003;101:624-32 pubmed
    The t(8;21) translocation, which encodes the AML1-ETO fusion protein (now known as RUNX1-CBF2T1), is one of the most frequent translocations in acute myeloid leukemia, although its role in leukemogenesis is unclear...
  46. Melnick A, Westendorf J, Polinger A, Carlile G, Arai S, Ball H, et al. The ETO protein disrupted in t(8;21)-associated acute myeloid leukemia is a corepressor for the promyelocytic leukemia zinc finger protein. Mol Cell Biol. 2000;20:2075-86 pubmed
    The ETO protein was originally identified by its fusion to the AML-1 transcription factor in translocation (8;21) associated with the M2 form of acute myeloid leukemia (AML)...
  47. Tiller K, Li L, Kumar S, Julian M, Garde S, Tessier P. Arginine mutations in antibody complementarity-determining regions display context-dependent affinity/specificity trade-offs. J Biol Chem. 2017;292:16638-16652 pubmed publisher
    ..This is especially concerning for positively charged CDR mutations that are linked to antibody polyspecificity...
  48. Karkov H, Woo J, Krogh B, Ahmadian H, Cramer S. Evaluation of selectivity in homologous multimodal chromatographic systems using in silico designed antibody fragment libraries. J Chromatogr A. 2015;1426:102-9 pubmed publisher
    ..For three of the Fab libraries, the CDR regions appeared as major binding sites for all multimodal ligands...
  49. Pan D, Chen Y, Du Y, Ren Z, Li X, Hu B. Methylation of promoter of RBL1 enhances the radioresistance of three dimensional cultured carcinoma cells. Oncotarget. 2017;8:4422-4435 pubmed publisher
    ..The treatments of irradiation or 5-Aza-CdR activated the demethylation of RBL1 promotor and resulted in the increased expression of RBL1 only in 3D A549 cells...
  50. Koenig P, Lee C, Sanowar S, Wu P, Stinson J, Harris S, et al. Deep Sequencing-guided Design of a High Affinity Dual Specificity Antibody to Target Two Angiogenic Factors in Neovascular Age-related Macular Degeneration. J Biol Chem. 2015;290:21773-86 pubmed publisher
    ..The data obtained from deep mutational scanning reveal that the majority of the 52 CDR residues are utilized differently for the two antigen binding function and permit, for the first time, the ..
  51. Steiniger S, Glanville J, Harris D, Wilson T, Ippolito G, Dunham S. Comparative analysis of the feline immunoglobulin repertoire. Biologicals. 2017;46:81-87 pubmed publisher
    ..All animals show a similarly skewed VH CDR-H3 profile and, when compared to canine, human and mouse, distinct differences are observed...
  52. Osman D, Gobert V, Ponthan F, Heidenreich O, Haenlin M, Waltzer L. A Drosophila model identifies calpains as modulators of the human leukemogenic fusion protein AML1-ETO. Proc Natl Acad Sci U S A. 2009;106:12043-8 pubmed publisher
    ..as RUNX1), including its DNA-binding domain, to the almost entire transcriptional corepressor ETO (also known as MTG8 or RUNX1T1)...
  53. Yeh J, Munson K, Chao Y, Peterson Q, Macrae C, Peterson R. AML1-ETO reprograms hematopoietic cell fate by downregulating scl expression. Development. 2008;135:401-10 pubmed
    AML1-ETO is one of the most common chromosomal translocation products associated with acute myelogenous leukemia (AML)...
  54. d Oleire Uquillas F, Jacobs H, Hanseeuw B, Marshall G, Properzi M, Schultz A, et al. Interactive versus additive relationships between regional cortical thinning and amyloid burden in predicting clinical decline in mild AD and MCI individuals. Neuroimage Clin. 2018;17:388-396 pubmed publisher
    ..and medial temporal and parietal cortices was related to higher baseline Clinical Dementia Rating Sum-of-Boxes (CDR-SB). Baseline A?-associated cortical thinning also predicted CDR-SB over time...
  55. Faber Z, Chen X, Gedman A, Boggs K, Cheng J, Ma J, et al. The genomic landscape of core-binding factor acute myeloid leukemias. Nat Genet. 2016;48:1551-1556 pubmed publisher
    ..This detailed analysis provides insights into the pathogenesis and development of CBF-AML, while highlighting dramatic differences in the landscapes of cooperating mutations for these related AML subtypes. ..
  56. Kang S, Woo J, Park H, Brown C, Hong S, Moon I. Objective Test of Cochlear Dead Region: Electrophysiologic Approach using Acoustic Change Complex. Sci Rep. 2018;8:3645 pubmed publisher
    ..study was to develop an objective and neurophysiologic method of identifying the presence of cochlear dead region (CDR) by combining acoustic change complex (ACC) responses with threshold-equalizing noise (TEN) test...
  57. Pereira A, de Vasconcelos Barros R, Pereira S. Pharmacopollution and Household Waste Medicine (HWM): how reverse logistics is environmentally important to Brazil. Environ Sci Pollut Res Int. 2017;24:24061-24075 pubmed publisher
    ..review based on the Cochrane Handbook and the National Health Service (NHS) Center for Reviews Dissemination (CDR) Report. The HWM phenomenon brings many environmental, public health, and, social challenges...
  58. Zhao S, Cao M, Wu H, Hu Y, Xue X. 5-aza-2'-deoxycytidine Inhibits the Proliferation of Lung Fibroblasts in Neonatal Rats Exposed to Hyperoxia. Pediatr neonatol. 2017;58:122-127 pubmed publisher
    ..P16 methylation plays an important role in the pathogenesis of BPD. 5-aza-2'-deoxycytidine (5-aza-CdR) is a major methyltransferase-specific inhibitor...
  59. Hairul Bahara N, Chin S, Choong Y, Lim T. Construction of a Semisynthetic Human VH Single-Domain Antibody Library and Selection of Domain Antibodies against α-Crystalline of Mycobacterium tuberculosis. J Biomol Screen. 2016;21:35-43 pubmed publisher
    ..diverse library is largely dependent on the diversity introduced within the complementarity-determining region (CDR) cassettes...
  60. Moustafa A, Hewedi D, Eissa A, Myers C, Sadek H. The relationship between associative learning, transfer generalization, and homocysteine levels in mild cognitive impairment. PLoS ONE. 2012;7:e46496 pubmed publisher
    ..relationship between cognitive function and total homocysteine levels in healthy subjects (Global Dementia Rating, CDR = 0) and individuals with MCI (CDR = 0.5)...
  61. Nady N, Gupta A, Ma Z, Swigut T, Koide A, Koide S, et al. ETO family protein Mtgr1 mediates Prdm14 functions in stem cell maintenance and primordial germ cell formation. elife. 2015;4:e10150 pubmed publisher
    ..Here, we show that this repressive function is mediated through an ETO-family co-repressor Mtgr1, which tightly binds to the pre-SET/SET domains of Prdm14 and co-occupies its genomic ..
  62. Chen C, Ma Z, Zhang H, Liu X, Yu Z. Krüppel-Like Factor 4 Enhances Sensitivity of Cisplatin to Esophageal Squamous Cell Carcinoma (ESCC) Cells. Med Sci Monit. 2017;23:3353-3359 pubmed
    ..5-Azacytidine-2'-deoxycytidine (5'-Aza-CdR) treatment and methylation-specific PCR (MS-PCR) were used to detect the methylation status for KLF4...
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    AML1-ETO and TEL-AML1 are chimeric proteins resulting from the t(8;21)(q22;q22) in acute myeloid leukemia, and the t(12;21)(p13;q22) in pre-B-cell leukemia, respectively...
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    ..The chromosomal translocation t(8;21), fusing the DNA binding domain of AML1 to the corepressor eight-twenty-one (ETO), is frequently associated with acute myeloid leukemia and generates the AML1/ETO (AE) fusion protein...
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    Fusion protein AML1-ETO, resulting from t(8;21) translocation, is highly related to leukemia development. It has been reported that full-length AML1-ETO blocks AML1 function and requires additional mutagenic events to promote leukemia...
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