erythropoietin

Summary

Gene Symbol: erythropoietin
Description: erythropoietin
Alias: DBAL, ECYT5, MVCD2, erythropoietin, epoetin
Species: human
Products:     erythropoietin

Top Publications

  1. Logan J, Allred E, Fichorova R, Engelke S, Dammann O, Leviton A. Endogenous erythropoietin varies significantly with inflammation-related proteins in extremely premature newborns. Cytokine. 2014;69:22-8 pubmed publisher
    b>Erythropoietin, a pluripotent glycoprotein essential for erythropoiesis, fetal growth, and development, has recently been implicated in innate immune regulation...
  2. Sakanaka M, Wen T, Matsuda S, Masuda S, Morishita E, Nagao M, et al. In vivo evidence that erythropoietin protects neurons from ischemic damage. Proc Natl Acad Sci U S A. 1998;95:4635-40 pubmed
    b>Erythropoietin (EPO) produced by the kidney and the liver (in fetuses) stimulates erythropoiesis. In the central nervous system, neurons express EPO receptor (EPOR) and astrocytes produce EPO...
  3. Gombos Z, Danihel L, Repiska V, Acs G, Furth E. Expression of erythropoietin and its receptor increases in colonic neoplastic progression: the role of hypoxia in tumorigenesis. Indian J Pathol Microbiol. 2011;54:273-8 pubmed publisher
    ..This process may also add to a therapeutic problem of solid tumor resistance to chemo- and radiation therapy. Erythropoietin (Epo) expression is induced by tissue hypoxia...
  4. Grimm C, Wenzel A, Groszer M, Mayser H, Seeliger M, Samardzija M, et al. HIF-1-induced erythropoietin in the hypoxic retina protects against light-induced retinal degeneration. Nat Med. 2002;8:718-24 pubmed
    b>Erythropoietin (Epo) is upregulated by hypoxia and provides protection against apoptosis of erythroid progenitors in bone marrow and brain neurons...
  5. Junk A, Mammis A, Savitz S, Singh M, Roth S, Malhotra S, et al. Erythropoietin administration protects retinal neurons from acute ischemia-reperfusion injury. Proc Natl Acad Sci U S A. 2002;99:10659-64 pubmed
    b>Erythropoietin (EPO) plays an important role in the brain's response to neuronal injury...
  6. Park K, Choi N, Koh S, Park H, Kim Y, Kim M, et al. L-DOPA neurotoxicity is prevented by neuroprotective effects of erythropoietin. Neurotoxicology. 2011;32:879-87 pubmed publisher
    ..Considering the well known neuroprotective effects of erythropoietin (EPO), the inhibitory effects of EPO on L-DOPA neurotoxicity need to be evaluated...
  7. Wang F, Zhang R, Beischlag T, Muchardt C, Yaniv M, Hankinson O. Roles of Brahma and Brahma/SWI2-related gene 1 in hypoxic induction of the erythropoietin gene. J Biol Chem. 2004;279:46733-41 pubmed
    Upon hypoxia, the human erythropoietin (EPO) gene is transactivated by the heterodimeric hypoxia-inducible factor 1 (HIF-1). Mammalian SWI/SNF is a chromatin-remodeling complex involved in the modulation of gene expression...
  8. Warnecke C, Zaborowska Z, Kurreck J, Erdmann V, Frei U, Wiesener M, et al. Differentiating the functional role of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha (EPAS-1) by the use of RNA interference: erythropoietin is a HIF-2alpha target gene in Hep3B and Kelly cells. FASEB J. 2004;18:1462-4 pubmed
    ..The same was found for the activation of reporter genes driven by hypoxia-responsive elements (HREs) from the erythropoietin (EPO), vascular endothelial growth factor, or phosphoglycerate kinase gene...
  9. Villa P, Bigini P, Mennini T, Agnello D, Laragione T, Cagnotto A, et al. Erythropoietin selectively attenuates cytokine production and inflammation in cerebral ischemia by targeting neuronal apoptosis. J Exp Med. 2003;198:971-5 pubmed
    ..Previous studies suggest that erythropoietin (EPO) attenuates both processes...

More Information

Publications91

  1. Wang Z, Shen L, Tu L, Hu D, Liu G, Zhou Z, et al. Erythropoietin protects retinal pigment epithelial cells from oxidative damage. Free Radic Biol Med. 2009;46:1032-41 pubmed publisher
    ..The aim of this study was to determine whether erythropoietin (EPO) protects cultured human RPE cells against oxidative damage and to identify the pathways that may mediate ..
  2. Tong Z, Yang Z, Patel S, Chen H, Gibbs D, Yang X, et al. Promoter polymorphism of the erythropoietin gene in severe diabetic eye and kidney complications. Proc Natl Acad Sci U S A. 2008;105:6998-7003 pubmed publisher
    ..However, the precise gene(s) and genetic variant(s) involved remain largely unknown. Erythropoietin (EPO) is a potent angiogenic factor observed in the diabetic human and mouse eye...
  3. García Ramírez M, Hernandez C, Simo R. Expression of erythropoietin and its receptor in the human retina: a comparative study of diabetic and nondiabetic subjects. Diabetes Care. 2008;31:1189-94 pubmed publisher
    The purpose of this study was to evaluate erythropoietin (Epo) and Epo receptor (EpoR) expression in the retina and in vitreous fluid from diabetic and nondiabetic donors...
  4. Shi Z, Hodges V, Dunlop E, Percy M, Maxwell A, El Tanani M, et al. Erythropoietin-induced activation of the JAK2/STAT5, PI3K/Akt, and Ras/ERK pathways promotes malignant cell behavior in a modified breast cancer cell line. Mol Cancer Res. 2010;8:615-26 pubmed publisher
    b>Erythropoietin (Epo), the major regulator of erythropoiesis, and its cognate receptor (EpoR) are also expressed in nonerythroid tissues, including tumors...
  5. Katsura Y, Okano T, Matsuno K, Osako M, Kure M, Watanabe T, et al. Erythropoietin is highly elevated in vitreous fluid of patients with proliferative diabetic retinopathy. Diabetes Care. 2005;28:2252-4 pubmed
  6. Lee Y, Vortmeyer A, Lubensky I, Vogel T, Ikejiri B, Ferlicot S, et al. Coexpression of erythropoietin and erythropoietin receptor in von Hippel-Lindau disease-associated renal cysts and renal cell carcinoma. Clin Cancer Res. 2005;11:1059-64 pubmed
    ..We show that VHL disease-associated renal clear cell carcinomas (RCC) consistently coexpress erythropoietin (Epo) and Epo receptor (EpoR)...
  7. Becerra S, Amaral J. Erythropoietin--an endogenous retinal survival factor. N Engl J Med. 2002;347:1968-70 pubmed
  8. Yasuda Y, Fujita Y, Masuda S, Musha T, Ueda K, Tanaka H, et al. Erythropoietin is involved in growth and angiogenesis in malignant tumours of female reproductive organs. Carcinogenesis. 2002;23:1797-805 pubmed
    The accumulating evidence that erythropoietin and erythropoietin receptor are expressed in various non-haematopoietic organs suggests that erythropoietin signalling might be involved in the growth of tumours, but this possibility has ..
  9. Siren A, Fratelli M, Brines M, Goemans C, Casagrande S, Lewczuk P, et al. Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress. Proc Natl Acad Sci U S A. 2001;98:4044-9 pubmed
    b>Erythropoietin (EPO) promotes neuronal survival after hypoxia and other metabolic insults by largely unknown mechanisms...
  10. Nagai A, Nakagawa E, Choi H, Hatori K, Kobayashi S, Kim S. Erythropoietin and erythropoietin receptors in human CNS neurons, astrocytes, microglia, and oligodendrocytes grown in culture. J Neuropathol Exp Neurol. 2001;60:386-92 pubmed
    b>Erythropoietin (EPO) is a hematopoietic growth factor that stimulates proliferation and differentiation of erythroid precursor cells and is also known to exert neurotrophic activity in the central nervous system (CNS)...
  11. Beleslin Cokic B, Cokic V, Yu X, Weksler B, Schechter A, Noguchi C. Erythropoietin and hypoxia stimulate erythropoietin receptor and nitric oxide production by endothelial cells. Blood. 2004;104:2073-80 pubmed
    b>Erythropoietin (EPO), a hypoxia-inducible cytokine, is required for survival, proliferation, and differentiation of erythroid progenitor cells...
  12. Hernandez C, Fonollosa A, García Ramírez M, Higuera M, Catalán R, Miralles A, et al. Erythropoietin is expressed in the human retina and it is highly elevated in the vitreous fluid of patients with diabetic macular edema. Diabetes Care. 2006;29:2028-33 pubmed
    b>Erythropoietin has been recently found to be increased in the vitreous fluid from ischemic retinal diseases such as proliferative diabetic retinopathy (PDR)...
  13. Weidemann A, Johnson R. Nonrenal regulation of EPO synthesis. Kidney Int. 2009;75:682-8 pubmed publisher
    b>Erythropoietin (EPO) is a circulating glycoprotein hormone whose principal function is thought to be red blood cell production...
  14. Brines M, Ghezzi P, Keenan S, Agnello D, de Lanerolle N, Cerami C, et al. Erythropoietin crosses the blood-brain barrier to protect against experimental brain injury. Proc Natl Acad Sci U S A. 2000;97:10526-31 pubmed
    b>Erythropoietin (EPO), recognized for its central role in erythropoiesis, also mediates neuroprotection when the recombinant form (r-Hu-EPO) is directly injected into ischemic rodent brain...
  15. Cumurcu T, Bulut Y, Demir H, Yenisehirli G. Aqueous humor erythropoietin levels in patients with primary open-angle glaucoma. J Glaucoma. 2007;16:645-8 pubmed
    To evaluate the levels of erythropoietin (EPO) in the aqueous humor in eyes with primary open-angle glaucoma (POAG) and without glaucoma...
  16. Um M, Gross A, Lodish H. A "classical" homodimeric erythropoietin receptor is essential for the antiapoptotic effects of erythropoietin on differentiated neuroblastoma SH-SY5Y and pheochromocytoma PC-12 cells. Cell Signal. 2007;19:634-45 pubmed
    The hematopoietic cytokine erythropoietin (Epo) exerts cytoprotective effects on several types of neuronal cells both in vivo and in culture...
  17. Beirao I, Moreira L, Barandela T, Lobato L, Silva P, Gouveia C, et al. Erythropoietin production by distal nephron in normal and familial amyloidotic adult human kidneys. Clin Nephrol. 2010;74:327-35 pubmed
    the kidney is the major site of erythropoietin production. Many efforts have been made to identify renal erythropoietin-producing cells...
  18. Gong K, Zhang N, Zhang K, Na Y. The relationship of erythropoietin overexpression with von Hippel-Lindau tumour suppressor gene mutations between hypoxia-inducible factor-1? and -2? in sporadic clear cell renal carcinoma. Int J Mol Med. 2010;26:907-12 pubmed
    ..The role of erythropoietin (EPO), a target gene for HIF, remains unknown for sporadic clear cell renal cell carcinoma (sCCRCC)...
  19. Digicaylioglu M, Lipton S. Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-kappaB signalling cascades. Nature. 2001;412:641-7 pubmed
    b>Erythropoietin, a kidney cytokine regulating haematopoiesis (the production of blood cells), is also produced in the brain after oxidative or nitrosative stress...
  20. Ashley R, Dubuque S, Dvorak B, Woodward S, Williams S, Kling P. Erythropoietin stimulates vasculogenesis in neonatal rat mesenteric microvascular endothelial cells. Pediatr Res. 2002;51:472-8 pubmed
    Human breast milk is a rich source of growth factors, including erythropoietin (Epo), the endogenous hormonal stimulant of erythropoiesis...
  21. Gong K, Zhang N, Zhang Z, Na Y. Coexpression of erythopoietin and erythopoietin receptor in sporadic clear cell renal cell carcinoma. Cancer Biol Ther. 2006;5:582-5 pubmed
    ..Recently, the erythropoietin (Epo) has been found to be upregulated in renal and other tumors associated with VHL disease...
  22. Van Vlerken L, van Soest H, Janssen M, Boland G, Drenth J, Burger D, et al. Suboptimal endogenous erythropoietin response in chronic hepatitis C patients during ribavirin and PEG interferon treatment. Eur J Gastroenterol Hepatol. 2010;22:1308-15 pubmed publisher
    ..on pegylated-interferon-ribavirin treatment were evaluated for haemoglobin, haematocrit, serum ribavirin and erythropoietin levels. About 99% of patients developed anaemia, with maximal decrease in haemoglobin of 2.5 ± 1...
  23. Vogel T, Brouwers F, Lubensky I, Vortmeyer A, Weil R, Walther M, et al. Differential expression of erythropoietin and its receptor in von hippel-lindau-associated and multiple endocrine neoplasia type 2-associated pheochromocytomas. J Clin Endocrinol Metab. 2005;90:3747-51 pubmed
    ..Studies in other VHL-associated tumors suggest that VHL gene deficiency causes coexpression of erythropoietin (Epo) and its receptor (Epo-R), which facilitates tumor growth...
  24. Munakata W, Ohashi K, Sakaguchi K, Horio H, Hishima T, Akiyama H, et al. Erythrocytosis caused by erythropoietin-producing thymic carcinoma. Int J Clin Oncol. 2010;15:220-3 pubmed publisher
    We describe the first reported case, in an 82-year-old man, of erythrocytosis caused by an erythropoietin (EPO)-producing thymic carcinoma...
  25. Irrera N, Bitto A, Pizzino G, Vaccaro M, Squadrito F, Galeano M, et al. Epoetin Alpha and Epoetin Zeta: A Comparative Study on Stimulation of Angiogenesis and Wound Repair in an Experimental Model of Burn Injury. Biomed Res Int. 2015;2015:968927 pubmed publisher
    ..Deep second-degree burns are characterized by delayed formation of granulation tissue and impaired angiogenesis. Erythropoietin (EPO) is able to stimulate angiogenesis and mitosis, activating vascularization and cell cycle...
  26. Reid G, Lois N. Erythropoietin in diabetic retinopathy. Vision Res. 2017;139:237-242 pubmed publisher
    Over the past years, knowledge has expanded with regards to the multiple roles played by erythropoietin (EPO) in the body...
  27. Panagopoulos V, Zinonos I, Leach D, Hay S, Liapis V, Zysk A, et al. Uncovering a new role for peroxidase enzymes as drivers of angiogenesis. Int J Biochem Cell Biol. 2015;68:128-38 pubmed publisher
  28. Becker S, Wang H, Simmons A, Suwanmanee T, Stoddard G, Kafri T, et al. Targeted Knockdown of Overexpressed VEGFA or VEGF164 in Müller cells maintains retinal function by triggering different signaling mechanisms. Sci Rep. 2018;8:2003 pubmed publisher
    ..Ganzfeld electroretinograms were increased in L-VEGFAshRNA or L-VEGF164shRNA compared to control. Erythropoietin (EPO), brain-derived neurotrophic factor, glial-derived neurotrophic factor, nerve growth factor, neurotrophin-..
  29. Xu C, Zhou T, He M, Sun Y. Differential up-regulation of erythropoietin and its receptor in benign and malignant prostatic tissue. Urol Oncol. 2010;28:314-9 pubmed publisher
    To investigate differential up-regulation of erythropoietin and its receptor in benign and malignant prostatic tissue...
  30. Gouveia A, Braga F, Mota M, Silva F, Brugiolo A, Oliveira E, et al. Enhanced expression of PD-L1 and IFN-? on dendritic cells is associated with BCG-induced Th2 inhibition. Cytokine. 2017;99:163-172 pubmed publisher
    ..These results indicated that neonatal BCG vaccination inhibits key features of allergic airway inflammation, probably by promoting T regulatory immune response via an enhanced expression of TLR2, TLR4 and PD-L1 on DCs. ..
  31. Cluzeau T, McGraw K, Irvine B, Masala E, Ades L, Basiorka A, et al. Pro-inflammatory proteins S100A9 and tumor necrosis factor-? suppress erythropoietin elaboration in myelodysplastic syndromes. Haematologica. 2017;102:2015-2020 pubmed publisher
    ..The role of myelodysplastic syndrome-related inflammatory proteins in endogenous erythropoietin regulation and response to erythroid-stimulating agents or lenalidomide has not been investigated...
  32. Castillo C, Zaror S, Gonzalez M, Hidalgo A, Burgos C, Cabezas O, et al. Neuroprotective effect of a new variant of Epo nonhematopoietic against oxidative stress. Redox Biol. 2018;14:285-294 pubmed publisher
    Human erythropoietin is mainly recognized for its hematopoietic function; however, by binding to its receptor (EpoR), it can activate different signaling pathways as STAT, PI3K, MAPK and RAS to increase cellular differentiation or provide ..
  33. Winter S, Shah K, Campo L, Turley H, Leek R, Corbridge R, et al. Relation of erythropoietin and erythropoietin receptor expression to hypoxia and anemia in head and neck squamous cell carcinoma. Clin Cancer Res. 2005;11:7614-20 pubmed
    The use of erythropoietin in head and neck squamous cell carcinoma (HNSCC) has been associated with poor survival...
  34. Ema M, Taya S, Yokotani N, Sogawa K, Matsuda Y, Fujii Kuriyama Y. A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development. Proc Natl Acad Sci U S A. 1997;94:4273-8 pubmed
    ..HLF) encoded by the isolated cDNA bound the hypoxia-response element (HRE) found in enhancers of genes for erythropoietin, vascular endothelial growth factor (VEGF), and various glycolytic enzymes, and activated transcription of a ..
  35. Ait Oudhia S, Vermeulen A, Krzyzanski W. Non-linear mixed effect modeling of the time-variant disposition of erythropoietin in anemic cancer patients. Biopharm Drug Dispos. 2011;32:1-15 pubmed publisher
    ..The aim was to develop a pharmacokinetic (PK) model that describes the time-dependent decline of epoetin alfa (rHuEPO) clearance following thrice (t.i.w.) or once (q.w...
  36. Nouri A, Nait Mohamed F, Laraba Djebari F. New and safe formulation for scorpion immunotherapy: Comparative study between saponin and FCA adjuvants associated to attenuated venom. Vaccine. 2018;36:1720-1727 pubmed publisher
    ..These results indicate that saponin formulation with irradiated antigen could be more efficient and safe immunizing preparation for the production of sera against scorpion envenomation. ..
  37. Mohamed S, Schaa K, Cooper M, Ahrens E, Alvarado A, COLAIZY T, et al. Genetic contributions to the development of retinopathy of prematurity. Pediatr Res. 2009;65:193-7 pubmed publisher
    ..003), AGTR1 (p = 0.005), TBX5 (p = 0.003), CETP (p = 0.004), and GP1BA (p = 0.005). Our data suggest that genetic risk factors contribute to the development of ROP. ..
  38. Vriend J, Reiter R. Melatonin and the von Hippel-Lindau/HIF-1 oxygen sensing mechanism: A review. Biochim Biophys Acta. 2016;1865:176-83 pubmed publisher
    ..A direct or indirect inhibitory action (via the reduction in ROS) of melatonin on proteasome activity would account for much of the published data. ..
  39. Sasaki H, Ochi N, Dell A, Fukuda M. Site-specific glycosylation of human recombinant erythropoietin: analysis of glycopeptides or peptides at each glycosylation site by fast atom bombardment mass spectrometry. Biochemistry. 1988;27:8618-26 pubmed
    We have previously determined the carbohydrate structure of human recombinant erythropoietin [Sasaki, H., Bothner, B., Dell, A., & Fukuda, M. (1987) J. Biol. Chem. 262, 12059-12076]...
  40. Alempijevic T, Zec S, Nikolic V, Veljkovic A, Milivojevic V, Dopsaj V, et al. Erythropoietin in Predicting Prognosis in Patients with Acute-on-Chronic Liver Failure. J Gastrointestin Liver Dis. 2016;25:473-479 pubmed publisher
    ..Novel therapies are being investigated such as Erythropoietin (EPO)...
  41. Moriconi F, Ramadori P, Schultze F, Blaschke M, Amanzada A, Khan S, et al. Characterization of the erythropoietin/erythropoietin receptor axis in a rat model of liver damage and cholangiocarcinoma development. Histochem Cell Biol. 2013;139:473-85 pubmed publisher
    It has been recently shown that the biological effects of erythropoietin (EPO) are not limited to the hematopoietic compartment but, as pleiotropic glycoprotein, this hormone can exert pro-angiogenic and tissue-protective functions also ..
  42. Xu P, Zhou Z, Xiong M, Zou W, Deng X, Ganaie S, et al. Parvovirus B19 NS1 protein induces cell cycle arrest at G2-phase by activating the ATR-CDC25C-CDK1 pathway. PLoS Pathog. 2017;13:e1006266 pubmed publisher
    ..Importantly, we found that the ATR-CHK1-CDC25C-CDK1 pathway was activated during B19V infection of EPCs, and that ATR activation played an important role in B19V infection-induced G2-phase arrest. ..
  43. Sodata P, Juntavee A, Juntavee N, Peerapattana J. Optimization of Adhesive Pastes for Dental Caries Prevention. AAPS PharmSciTech. 2017;18:3087-3096 pubmed publisher
    ..This result demonstrated that optimization is an efficient technique in the formulation development of the adhesive pastes. In addition, the optimal adhesive pastes could enhance acid resistance activity to the tooth enamel. ..
  44. Zafeiriou M. The Erythropoietin System Protects the Heart Upon Injury by Cardiac Progenitor Cell Activation. Vitam Horm. 2017;105:233-248 pubmed publisher
    b>Erythropoietin (EPO) is a growth hormone, widely known for its role in erythropoiesis...
  45. Panagopoulos V, Leach D, Zinonos I, Ponomarev V, Licari G, Liapis V, et al. Inflammatory peroxidases promote breast cancer progression in mice via regulation of the tumour microenvironment. Int J Oncol. 2017;50:1191-1200 pubmed publisher
    ..Importantly, this identifies inflammatory peroxidases as therapeutic targets in breast cancer therapy. ..
  46. Gurieva I, Frýdlová J, Rychtarčíková Z, Vokurka M, Truksa J, Krijt J. Erythropoietin administration increases splenic erythroferrone protein content and liver TMPRSS6 protein content in rats. Blood Cells Mol Dis. 2017;64:1-7 pubmed publisher
    ..study was to examine splenic ERFE and liver TMPRSS6 synthesis in rats treated with a combination of iron and erythropoietin (EPO)...
  47. Kondiah P, Choonara Y, Tomar L, Tyagi C, Kumar P, du Toit L, et al. Development of a Gastric Absorptive, Immediate Responsive, Oral Protein-Loaded Versatile Polymeric Delivery System. AAPS PharmSciTech. 2017;18:2479-2493 pubmed publisher
    A multifunctional platform to deliver three diverse proteins of insulin, interferon beta (INF-?) and erythropoietin (EPO), using a novel copolymeric microparticulate system of TMC-PEGDMA-MAA, was synthesised as an intelligent pH-..
  48. Ohlsson A, Aher S. Early erythropoiesis-stimulating agents in preterm or low birth weight infants. Cochrane Database Syst Rev. 2017;11:CD004863 pubmed publisher
    Preterm infants have low plasma levels of erythropoietin (EPO), providing a rationale for the use of erythropoiesis-stimulating agents (ESAs) to prevent or treat anaemia and to provide neuro protection and protection against necrotising ..
  49. Turkmen E, Yildirim T, Yilmaz R, Hazirolan T, Eldem G, Yilmaz E, et al. HFE gene mutation is a risk factor for tissue iron accumulation in hemodialysis patients. Hemodial Int. 2017;21:359-366 pubmed publisher
    ..Hemoglobin, ferritin, TSAT in the preceding 2 years were recorded. Iron and erythropoietin (EPO) administered during this period were calculated...
  50. Li Q, Kang C. Erythropoietin Receptor Structural Domains. Vitam Horm. 2017;105:1-17 pubmed publisher
    b>Erythropoietin (EPO) is a hormone that is important for regulating red blood cell production. It is functional through binding to its receptor-EpoR. EpoR is a single-span membrane protein...
  51. Liu J, Zhang S, Luo J, Hu Q, Ma W, Wu S. Changes in cerebrovascular reactivity in healthy adults after acute exposure to high altitude. Eur Rev Med Pharmacol Sci. 2018;22:1437-1450 pubmed publisher
  52. Kumari A, Dash D, Singh R. Lipopolysaccharide (LPS) exposure differently affects allergic asthma exacerbations and its amelioration by intranasal curcumin in mice. Cytokine. 2015;76:334-342 pubmed publisher
    ..Schedule and dose of LPS exposure determines asthma exacerbations and intranasal curcumin could be better immunomodulatory agent in LPS exposed asthma exacerbations. ..
  53. Miao S, Wang S, Cheng X, Li Y, Zhang Q, Li G, et al. Erythropoietin promoted the proliferation of hepatocellular carcinoma through hypoxia induced translocation of its specific receptor. Cancer Cell Int. 2017;17:119 pubmed publisher
    b>Erythropoietin (EPO) is a hypoxia-inducible stimulator of erythropoiesis. Besides its traditional application in anemia therapy, it offers an effective treatment in the cancer patients, especially those who receive chemotherapy...
  54. Yang Y, Zhou Y, Yu L, Li X, Shi X, Qin X, et al. A novel reporter gene assay for recombinant human erythropoietin (rHuEPO) pharmaceutical products. J Pharm Biomed Anal. 2014;100:316-321 pubmed publisher
    Accurate determination of in vitro biological activity of therapeutic erythropoietin is essential in quality control of recombinant human erythropoietin (rHuEPO) pharmaceutical products...
  55. Morley R, Moore V, Dwyer T, Owens J, Umstad M, Carlin J. Association between erythropoietin in cord blood of twins and size at birth: does it relate to gestational factors or to factors during labor or delivery?. Pediatr Res. 2005;57:680-4 pubmed
    We hypothesized that cord blood erythropoietin (EPO), a marker of fetal hypoxia, relates to gestational factors and not solely those associated with delivery...
  56. Zheng L, Xu J, Qiu W, Liu X, Zhao C, Chen D, et al. Cardioprotection of exogenous erythropoietin in mice with ligature-induced aortic stenosis: effects on maladaptive cardiac hypertrophy. J Physiol Pharmacol. 2010;61:13-20 pubmed
    Pre-operative treatment with recombinant human erythropoietin may improve aortic stenosis patients' condition, including anemia and/or cardiac dysfunction, for subjecting to aortic valve replacement...
  57. Zhou J, Li J, Rosenbaum D, Zhuang J, Poon C, Qin P, et al. The prolyl 4-hydroxylase inhibitor GSK360A decreases post-stroke brain injury and sensory, motor, and cognitive behavioral deficits. PLoS ONE. 2017;12:e0184049 pubmed publisher
    ..GSK360A exposure and plasma, kidney and brain HIF-PHD pharmacodynamics endpoints (e.g., erythropoietin; EPO and Vascular Endothelial Growth Factor; VEGF) were measured...
  58. Yoon S, Rhee S, Heo S, Oh T, Yoon S, Cho J, et al. Comparable pharmacokinetics and pharmacodynamics of two epoetin alfa formulations Eporon® and Eprex® following a single subcutaneous administration in healthy male volunteers. Drug Des Devel Ther. 2017;11:3127-3135 pubmed publisher
    ..assess and compare the pharmacokinetic (PK) and pharmacodynamic (PD) properties following a single subcutaneous injection of epoetin alfa (Eporon®) with those of the comparator (Eprex®) in healthy male subjects.
  59. Sala M, Chen C, Zhang Q, Do Umehara H, Wu W, Misharin A, et al. JNK2 up-regulates hypoxia-inducible factors and contributes to hypoxia-induced erythropoiesis and pulmonary hypertension. J Biol Chem. 2018;293:271-284 pubmed publisher
    ..erythropoiesis and were less prone to polycythemia because of decreased expression of the HIF target gene erythropoietin (Epo)...
  60. Wang J, Hayashi Y, Yokota A, Xu Z, Zhang Y, Huang R, et al. Expansion of EPOR-negative macrophages besides erythroblasts by elevated EPOR signaling in erythrocytosis mouse models. Haematologica. 2018;103:40-50 pubmed publisher
    Activated erythropoietin (EPO) receptor (EPOR) signaling causes erythrocytosis. The important role of macrophages for the erythroid expansion and differentiation process has been reported, both in baseline and stress erythropoiesis...
  61. Handelman G. Newer strategies for anemia prevention in hemodialysis. Int J Artif Organs. 2007;30:1014-9 pubmed
    Anemia prevention for hemodialysis relies primarily on supplemental erythropoietin (EPO) and intravenous iron (IV-iron)...
  62. Nakamura R, Takahashi A, Yamada T, Miyai N, Irie H, Kinoshita N, et al. Erythropoietin in patients with acute coronary syndrome and its cardioprotective action after percutaneous coronary intervention. Circ J. 2009;73:1920-6 pubmed
    b>Erythropoietin (EPO) has been shown to have effects beyond hematopoiesis, such as prevention of cardiac apoptosis...
  63. Kang Y, Digicaylioglu M, Russo R, Kaul M, Achim C, Fletcher L, et al. Erythropoietin plus insulin-like growth factor-I protects against neuronal damage in a murine model of human immunodeficiency virus-associated neurocognitive disorders. Ann Neurol. 2010;68:342-52 pubmed publisher
    ..Here, we report that chronic treatment with erythropoietin (EPO) and insulin-like growth factor-I (IGF-I) protects against HIV/gp120-mediated neuronal damage in culture ..
  64. Pulte E, McKenzie S, Caro J, Ballas S. Erythropoietin levels in patients with sickle cell disease do not correlate with known inducers of erythropoietin. Hemoglobin. 2014;38:385-9 pubmed publisher
    Previous studies have suggested that erythropoietin (Epo) levels may be inappropriately low in patients with sickle cell disease compared to the extent of the related anemia they demonstrate. Here, we evaluate Epo level vs...
  65. Ismailov R. The role of erythropoietin in the "stroke belt" phenomenon. Med Hypotheses. 2012;79:181-5 pubmed publisher
    ..hypothesize that this nonrandom stroke distribution is related to regional differences in individual levels of erythropoietin (EPO), a hormone, which production depends on the tissue hypoxia due to variation in altitude...
  66. Ribatti D, Nico B, Perra M, Longo V, Maxia C, Annese T, et al. Erythropoietin is involved in angiogenesis in human primary melanoma. Int J Exp Pathol. 2010;91:495-9 pubmed publisher
    ..the extent of angiogenesis, evaluated as microvascular volume density, immunoreactivity of tumour cells to erythropoietin (Epo) and of endothelial cells to Epo receptor (EpoR) have been correlated in human primary melanoma specimens...
  67. Kastner A, Grube S, El Kordi A, Stepniak B, Friedrichs H, Sargin D, et al. Common variants of the genes encoding erythropoietin and its receptor modulate cognitive performance in schizophrenia. Mol Med. 2012;18:1029-40 pubmed publisher
    b>Erythropoietin (EPO) improves cognitive performance in clinical studies and rodent experiments...
  68. Jacobs K, Shoemaker C, Rudersdorf R, Neill S, Kaufman R, Mufson A, et al. Isolation and characterization of genomic and cDNA clones of human erythropoietin. Nature. 1985;313:806-10 pubmed
    The glycoprotein hormone erythropoietin regulates the level of oxygen in the blood by modulating the number of circulating erythrocytes, and is produced in the kidney or liver of adult and the liver of fetal or neonatal mammals...
  69. Capalbo S, Battista C, Delia M, Ciancio A, De Santis G, Dargenio M, et al. Evaluation of tumor necrosis factor-alpha and erythropoietin serum levels in B-cell chronic lymphocytic leukemia patients with anemia. Acta Haematol. 2002;108:84-9 pubmed
    Serum levels of tumor necrosis factor-alpha (TNF-alpha) and of erythropoietin (Epo) have been evaluated in 100 patients with B-cell chronic lymphocytic leukemia (CLL) in order to determine whether these factors could be significant in the ..
  70. Walrafen P, Verdier F, Kadri Z, Chretien S, Lacombe C, Mayeux P. Both proteasomes and lysosomes degrade the activated erythropoietin receptor. Blood. 2005;105:600-8 pubmed
    Activation of the erythropoietin receptor (EpoR) after Epo binding is very transient because of the rapid activation of strong down-regulation mechanisms that quickly decrease Epo sensitivity of the cells...
  71. Zhou Z, Li F, Zheng Z, Li Y, Chen T, Gao W, et al. Erythropoietin regulates immune/inflammatory reaction and improves neurological function outcomes in traumatic brain injury. Brain Behav. 2017;7:e00827 pubmed publisher
    ..Recently, neuroprotective effects of erythropoietin (EPO) have been demonstrated in addition to its principal function in erythropoiesis, and hence it is viewed ..
  72. London G, Mann J, Goldsmith D, Combe C, Dellanna F, Zaoui P, et al. Long-term treatment with biosimilar epoetin-? (HX575) in hemodialysis patients with renal anemia: real-world effectiveness and safety in the MONITOR-CKD5 study?. Clin Nephrol. 2017;: pubmed publisher
    To assess real-world effectiveness and safety of intravenous (IV) HX575, a biosimilar epoetin-?, in hemodialysis (HD) patients.
  73. Ling S, Ni R, Yuan Y, Dang Y, Zhou Q, Liang S, et al. Natural compound bavachalcone promotes the differentiation of endothelial progenitor cells and neovascularization through the ROR?-erythropoietin-AMPK axis. Oncotarget. 2017;8:86188-86205 pubmed publisher
    ..Overall, this study revealed that BavaC promotes EPC differentiation and neovascularization through a ROR?-EPO-AMPK axis. BavaC can be used as a promising angiogenesis agent for enhancing angiogenesis and tissue repair...
  74. Chang H, Huang D, Wu M, Chu C, Tzeng S, Lin W. Spleen tyrosine kinase mediates the actions of EPO and GM-CSF and coordinates with TGF-? in erythropoiesis. Biochim Biophys Acta Mol Cell Res. 2017;1864:687-696 pubmed publisher
    b>Erythropoietin (EPO) and GM-CSF are involved in erythropoiesis, while TGF-? inhibits proliferation but potentiates differentiation of erythroblasts...
  75. Nakazaki K, Nannya Y, Kurokawa M. Distribution of serum erythropoietin levels in lower risk myelodysplastic syndrome cases with anemia. Int J Hematol. 2014;99:53-6 pubmed publisher
    ..syndrome (MDS) state that the standard therapy for lower risk MDS patients with symptomatic anemia of serum erythropoietin (EPO) <500 IU/L is erythroid-stimulating agents (ESAs)...
  76. Miskowiak K, O Sullivan U, Harmer C. Erythropoietin enhances hippocampal response during memory retrieval in humans. J Neurosci. 2007;27:2788-92 pubmed
    Although erythropoietin (Epo) is best known for its effects on erythropoiesis, recent evidence suggests that it also has neurotrophic and neuroprotective properties in animal models of hippocampal function...
  77. Zhao Y, Niu Y, Zhou Z, Liu F, Wang J, Xu J, et al. [Hydrogen peroxide induces expression and transcription of erythropoietin in the human retinal pigment epithelium cells]. Zhonghua Yan Ke Za Zhi. 2007;43:44-8 pubmed
    To investigate the expression of erythropoietin (EPO) in human fetal retinal pigment epithelium (hfRPE) cells exposed to oxidative stress induced by hydrogen peroxide (H(2)O(2)) and to study the mechanisms...
  78. Wang D, Song Y, Zhang J, Pang W, Wang X, Zhu Y, et al. AMPK-KLF2 signaling pathway mediates the proangiogenic effect of erythropoietin in endothelial colony forming cells. Am J Physiol Cell Physiol. 2017;:ajpcell.00257.2016 pubmed publisher
    ..The angiogenic properties of ECFCs could be influenced by various cytokines, chemokines, and growth factors. Erythropoietin (EPO) is a promising cytokine participating in angiogenesis...
  79. Pradeep S, Huang J, Mora E, Nick A, Cho M, Wu S, et al. Erythropoietin Stimulates Tumor Growth via EphB4. Cancer Cell. 2015;28:610-622 pubmed publisher
    While recombinant human erythropoietin (rhEpo) has been widely used to treat anemia in cancer patients, concerns about its adverse effects on patient survival have emerged...
  80. Gurusamy P, Schäfer H, Ramamoorthy S, Wink M. Biologically active recombinant human erythropoietin expressed in hairy root cultures and regenerated plantlets of Nicotiana tabacum L. PLoS ONE. 2017;12:e0182367 pubmed publisher
    ..In addition, the rhEPO was detected to an amount 14.8 ng g-1 of total soluble leaf protein in transgenic T0 generation plantlets regenerated from hairy root cultures with cal signal peptide. ..
  81. Hirschler Laszkiewicz I, Tong Q, Waybill K, Conrad K, Keefer K, Zhang W, et al. The transient receptor potential (TRP) channel TRPC3 TRP domain and AMP-activated protein kinase binding site are required for TRPC3 activation by erythropoietin. J Biol Chem. 2011;286:30636-46 pubmed publisher
    Modulation of intracellular calcium ([Ca(2+)](i)) by erythropoietin (Epo) is an important signaling pathway controlling erythroid proliferation and differentiation...
  82. Chung J, Wittig J, Ghamari A, Maeda M, Dailey T, Bergonia H, et al. Erythropoietin signaling regulates heme biosynthesis. elife. 2017;6: pubmed publisher
    ..Here, using zebrafish, murine, and human models, we show that erythropoietin (EPO) signaling, together with the GATA1 transcriptional target, AKAP10, regulates heme biosynthesis ..