Gene Symbol: ERV3-1
Description: endogenous retrovirus group 3 member 1, envelope
Alias: ERV-R, ERV3, ERVR, HERV-R, HERVR, envR, endogenous retrovirus group 3 member 1 Env polyprotein, ERV-R envelope protein, ERV3-1 envelope protein, HERV-R envelope protein, HERV-R_7q21.2 provirus ancestral Env polyprotein, endogenous retroviral sequence 3, endogenous retrovirus group 3, member 1
Species: human
Products:     ERV3-1

Top Publications

  1. Alsaleh A, Whiley D, Bialasiewicz S, Lambert S, Ware R, Nissen M, et al. Nasal swab samples and real-time polymerase chain reaction assays in community-based, longitudinal studies of respiratory viruses: the importance of sample integrity and quality control. BMC Infect Dis. 2014;14:15 pubmed publisher
    ..specimen collection was assessed by screening for human deoxyribonucleic acid (DNA) using endogenous retrovirus 3 (ERV3)...
  2. Chattopadhyay A, Aguilar P, Bopp N, Yarovinsky T, Weaver S, Rose J. A recombinant virus vaccine that protects against both Chikungunya and Zika virus infections. Vaccine. 2018;36:3894-3900 pubmed publisher
    ..Our single-dose vaccine could provide durable, low-cost protection against both CHIKV and ZIKV for people traveling to or living in areas where both viruses are circulating, which include most tropical regions in the world. ..
  3. Chong A, Kojima K, Jurka J, Ray D, Smit A, Isberg S, et al. Evolution and gene capture in ancient endogenous retroviruses - insights from the crocodilian genomes. Retrovirology. 2014;11:71 pubmed publisher
    ..This class shares some sequence similarity and sequence characteristics with ERV3, although it is phylogenetically distinct from the other ERV classes...
  4. Barletta F, Vandelannoote K, Collantes J, Evans C, Arévalo J, Rigouts L. Standardization of a TaqMan-based real-time PCR for the detection of Mycobacterium tuberculosis-complex in human sputum. Am J Trop Med Hyg. 2014;91:709-14 pubmed publisher
    ..The human ERV3 sequence was used as an internal control. 3 of 112 (3%) qPCR failed...
  5. Podgornaya O, Ostromyshenskii D, Enukashvily N. Who Needs This Junk, or Genomic Dark Matter. Biochemistry (Mosc). 2018;83:450-466 pubmed publisher
    ..with the whole genome, but there are differences in distribution of certain elements: while MaLR-like elements (ERV3) are dominant in the whole genome, intracisternal A-particles and corresponding LTR (ERV2) are prevalent in HChr...
  6. Michna A, Schötz U, Selmansberger M, Zitzelsberger H, Lauber K, Unger K, et al. Transcriptomic analyses of the radiation response in head and neck squamous cell carcinoma subclones with different radiation sensitivity: time-course gene expression profiles and gene association networks. Radiat Oncol. 2016;11:94 pubmed publisher
    ..Also, the expression of endogenous retrovirus ERV3-1in response to irradiation has been observed, and the related gene association networks have been identified...
  7. Zare M, Mostafaei S, Ahmadi A, Azimzadeh Jamalkandi S, Abedini A, Esfahani Monfared Z, et al. Human endogenous retrovirus env genes: Potential blood biomarkers in lung cancer. Microb Pathog. 2018;115:189-193 pubmed publisher
    ..In conclusion, these four HERV families could be considered as promising non-invasive blood-based biomarkers for prognosis, early detection, and monitoring of lung cancer. ..
  8. Frese S, Ruebner M, Suhr F, Konou T, Tappe K, Toigo M, et al. Long-Term Endurance Exercise in Humans Stimulates Cell Fusion of Myoblasts along with Fusogenic Endogenous Retroviral Genes In Vivo. PLoS ONE. 2015;10:e0132099 pubmed publisher
    ..increase of putative muscle-cell fusogenic genes Syncytin-1 and Syncytin-3, but also for the non-fusogenic erv3. Immunohistochemistry analyses showed that Syncytin-1 mainly localized to the sarcolemma of myofibers positive for ..
  9. Ostromyshenskii D, Chernyaeva E, Kuznetsova I, Podgornaya O. Mouse chromocenters DNA content: sequencing and in silico analysis. BMC Genomics. 2018;19:151 pubmed publisher chromocenters differs from the whole genome: IAP (ERV2 class) is the most numerous in ChrmC while MaLR (ERV3 class) prevails in the reference genome...

More Information


  1. Zhou L, Wang Q, Gu C, Li N, Zhou J, Sun X, et al. Sex Differences in the Effects of Obesity on Lung Volume. Am J Med Sci. 2017;353:224-229 pubmed publisher
    ..354, P < 0.01; r = 0.206, P < 0.05; r = -0.335, P < 0.01), whereas only on ERV in males (r = -0.230, P < 0.05). BMI affected the lung volume, and females were more susceptible to the effects than males. ..
  2. Sasaki T. [Integration and expression of human endogenous retrovirus]. Hokkaido Igaku Zasshi. 1991;66:794-803 pubmed
    ..To know the aspect of their integration and expression in human, lambda 4-1 and ERV3 were investigated by using genomic DNA or placental RNA from Japanese origin...
  3. Kang Y, Jo J, Ock M, Chang H, Baek K, Lee J, et al. Human ERV3-1 env protein expression in various human tissues and tumours. J Clin Pathol. 2014;67:86-90 pubmed publisher
  4. Andersson A, Merza M, Venables P, Ponten F, Sundstrom J, Cohen M, et al. Elevated levels of the endogenous retrovirus ERV3 in human sebaceous glands. J Invest Dermatol. 1996;106:125-8 pubmed
    b>ERV3 (HERV-R) is a complete human endogenous retrovirus located on the long arm of chromosome 7. Long terminal repeat-envelope (env) gene spliced mRNAs of 9 and 3...
  5. Kato N, Shimotohno K, VanLeeuwen D, Cohen M. Human proviral mRNAs down regulated in choriocarcinoma encode a zinc finger protein related to Krüppel. Mol Cell Biol. 1990;10:4401-5 pubmed
    RNA transcripts of the HERV-R (ERV3) human provirus that are abundant in placenta but absent in choriocarcinoma contain nonproviral genomic sequences at their 3' ends. We report here the isolation of cDNA clones of these genomic sequences...
  6. Blomberg J, Benachenhou F, Blikstad V, Sperber G, Mayer J. Classification and nomenclature of endogenous retroviral sequences (ERVs): problems and recommendations. Gene. 2009;448:115-23 pubmed publisher
    ..A dedicated, permanent, international consortium would best be suited to integrate and communicate our current and future knowledge on repetitive, mobile elements in general to the scientific community. ..
  7. Herv C, Forrest G, L wer R, Griffiths D, Venables P. Conservation and loss of the ERV3 open reading frame in primates. Genomics. 2004;83:940-3 pubmed publisher
    The human endogenous retrovirus ERV3 possesses an open reading frame for a truncated envelope, which is expressed as mRNA and protein. Here we examine the env sequence in primates for evidence of evolutionary conservation...
  8. Andersson A, Venables P, Tönjes R, Scherer J, Eriksson L, Larsson E. Developmental expression of HERV-R (ERV3) and HERV-K in human tissue. Virology. 2002;297:220-5 pubmed
    The human endogenous retroviruses (HERVs), ERV3 (HERV-R) and HERV-K, are both known to be transcriptionally active in human placenta. In the case of ERV3 there is also indirect evidence for its participation in cellular differentiation...
  9. Lin L, Xu B, Rote N. The cellular mechanism by which the human endogenous retrovirus ERV-3 env gene affects proliferation and differentiation in a human placental trophoblast model, BeWo. Placenta. 2000;21:73-8 pubmed
    ..Inhibition of ERV-3 env induced hCG production with H89 had no significant effect on cell growth when compared with cells transfected with vector alone. ..
  10. Kim H, Crow T, Hyun B. Assignment of the endogenous retrovirus HERV-R (ERV3) to human chromosome 7q11.2 by radiation hybrid mapping. Cytogenet Cell Genet. 2000;89:10 pubmed
  11. Kato N, Larsson E, Cohen M. Absence of expression of a human endogenous retrovirus is correlated with choriocarcinoma. Int J Cancer. 1988;41:380-5 pubmed
    We examined the RNA expression of a human endogenous provirus, termed ERV3, in 170 human tissue and cell specimens. The highest expression was found in normal placental chorionic villi as mRNAs of 9, 7.3, and 3.5 kb. The 7...
  12. Cohen M, Kato N, Larsson E. ERV3 human endogenous provirus mRNAs are expressed in normal and malignant tissues and cells, but not in choriocarcinoma tumor cells. J Cell Biochem. 1988;36:121-8 pubmed
    Messenger RNA expression of a human endogenous provirus, ERV3, has been characterized in 170 specimens of normal and malignant human tissues and cells...
  13. de Parseval N, Heidmann T. Physiological knockout of the envelope gene of the single-copy ERV-3 human endogenous retrovirus in a fraction of the Caucasian population. J Virol. 1998;72:3442-5 pubmed
    ..This natural knockout provides a mean to investigate other potential roles for this otherwise highly conserved gene. ..
  14. O Connell C, Cohen M. The long terminal repeat sequences of a novel human endogenous retrovirus. Science. 1984;226:1204-6 pubmed
    ..The 5' LTR is followed by a presumptive primer binding site unlike that of any known mammalian type C retrovirus, exhibiting 17 out of 18 nucleotides complementary to arginine transfer RNA rather than proline transfer RNA. ..
  15. Larsson E, Venables P, Andersson A, Fan W, Rigby S, Botling J, et al. Tissue and differentiation specific expression on the endogenous retrovirus ERV3 (HERV-R) in normal human tissues and during induced monocytic differentiation in the U-937 cell line. Leukemia. 1997;11 Suppl 3:142-4 pubmed
    b>ERV3 (HERV-R) is a complete, single copy human endogenous retrovirus located on the long arm of chromosome 7...
  16. Kato N, Pfeifer Ohlsson S, Kato M, Larsson E, Rydnert J, Ohlsson R, et al. Tissue-specific expression of human provirus ERV3 mRNA in human placenta: two of the three ERV3 mRNAs contain human cellular sequences. J Virol. 1987;61:2182-91 pubmed
    Three polyadenylated RNAs, 9, 7.3, and 3.5 kilobases long, of a human endogenous retrovirus, ERV3, are abundant in human placental chorion, representing about 0.03 to 0.05% of the total mRNA...
  17. Bustamante Rivera Y, Brütting C, Schmidt C, Volkmer I, Staege M. Endogenous Retrovirus 3 - History, Physiology, and Pathology. Front Microbiol. 2017;8:2691 pubmed publisher
    ..The composition of EVE varies between different species. The endogenous retrovirus 3 (ERV3) is one of these elements that is present only in humans and other Catarrhini...
  18. Cohen M, Powers M, O CONNELL C, Kato N. The nucleotide sequence of the env gene from the human provirus ERV3 and isolation and characterization of an ERV3-specific cDNA. Virology. 1985;147:449-58 pubmed
    The nucleotide sequence of the env gene of a previously described human provirus (ERV3) has been determined beginning near the 3'-end of the pol gene and continuing through the 3'-LTR...
  19. Soygur B, Sati L. The role of syncytins in human reproduction and reproductive organ cancers. Reproduction. 2016;152:R167-78 pubmed publisher
    ..In this review, we summarize how syncytins and their receptors are involved in fusion events during human reproduction. The significance of syncytins in tumorigenesis is also discussed. ..
  20. Bolze P, Patrier S, Cheynet V, Oriol G, Massardier J, Hajri T, et al. Expression patterns of ERVWE1/Syncytin-1 and other placentally expressed human endogenous retroviruses along the malignant transformation process of hydatidiform moles. Placenta. 2016;39:116-24 pubmed publisher
    ..levels of its locus ERVWE1, its interaction partners (hASCT1, hASCT2, TLR4 and DC-SIGN) and two loci (ERVFRDE1 and ERV3) involved the expression of other placental envelopes were assessed by real-time PCR...
  21. Venables P, Brookes S, Griffiths D, Weiss R, Boyd M. Abundance of an endogenous retroviral envelope protein in placental trophoblasts suggests a biological function. Virology. 1995;211:589-92 pubmed
    ..The similarity of a domain of ERV-3 env to putative immunosuppressive p15E sequences suggests that ERV-3 might form part of the placental immunosuppressive barrier between mother and foetus. ..
  22. Larsson E, Andersson A, Nilsson B. Expression of an endogenous retrovirus (ERV3 HERV-R) in human reproductive and embryonic tissues--evidence for a function for envelope gene products. Ups J Med Sci. 1994;99:113-20 pubmed
    b>ERV3 (HERV-R) is a complete human endogenous retrovirus located on the long arm of chromosome 7. It is expressed in several human tissues as LTR env spliced transcripts (9 and 3.5 kb)...
  23. Lee S, Kang Y, Jo J, Ock M, Baek K, Eo J, et al. Elevation of human ERV3-1 env protein expression in colorectal cancer. J Clin Pathol. 2014;67:840-4 pubmed
  24. Andersson A, Svensson A, Rolny C, Andersson G, Larsson E. Expression of human endogenous retrovirus ERV3 (HERV-R) mRNA in normal and neoplastic tissues. Int J Oncol. 1998;12:309-13 pubmed
    We investigated the mRNA expression of the human endogenous retrovirus ERV3 (HERV-R) in several normal and corresponding tumor tissues. The env gene of ERV3 is expressed as mRNA in several tissues...
  25. Rasmussen H, Clausen J. Large number of polymorphic nucleotides and a termination codon in the env gene of the endogenous human retrovirus ERV3. Dis Markers. 1998;14:127-33 pubmed
    The terminal portion of the pol gene and the entire env gene of the human endogenous retrovirus ERV3 was screened for polymorphic nucleotides...
  26. de Parseval N, Lazar V, Casella J, Benit L, Heidmann T. Survey of human genes of retroviral origin: identification and transcriptome of the genes with coding capacity for complete envelope proteins. J Virol. 2003;77:10414-22 pubmed
    ..The present study provides a comprehensive survey of candidate genes and tools for a precise evaluation of their involvement in these processes. ..
  27. Sibata M, Ikeda H, Katumata K, Takeuchi K, Wakisaka A, Yoshoki T. Human endogenous retroviruses: expression in various organs in vivo and its regulation in vitro. Leukemia. 1997;11 Suppl 3:145-6 pubmed
    ..b>ERV3 (HERV-R) mRNA was expressed in many organs, and the level of expression in individuals and organs considerably ..
  28. O CONNELL C, O BRIEN S, Nash W, Cohen M. ERV3, a full-length human endogenous provirus: chromosomal localization and evolutionary relationships. Virology. 1984;138:225-35 pubmed
    A full-length human endogenous provirus termed ERV3 was isolated from a human fetal recombinant DNA library by low stringency hybridization with two probes: baboon endogenous virus LTR; and a pol-env subclone from the endogenous ..
  29. Andersson A, Yun Z, Sperber G, Larsson E, Blomberg J. ERV3 and related sequences in humans: structure and RNA expression. J Virol. 2005;79:9270-84 pubmed
    The ERV3 locus at chromosome 7q11 is a much studied human endogenous retroviral (HERV) sequence, owing to an env open reading frame (ORF) and placental RNA and protein expression...
  30. Blaise S, de Parseval N, B nit L, Heidmann T. Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution. Proc Natl Acad Sci U S A. 2003;100:13013-8 pubmed publisher