Gene Symbol: ERRFI1
Description: ERBB receptor feedback inhibitor 1
Alias: GENE-33, MIG-6, MIG6, RALT, ERBB receptor feedback inhibitor 1, mitogen-inducible gene 6 protein, receptor-associated late transducer
Species: human
Products:     ERRFI1

Top Publications

  1. Fiorini M, Ballaro C, Sala G, Falcone G, Alema S, Segatto O. Expression of RALT, a feedback inhibitor of ErbB receptors, is subjected to an integrated transcriptional and post-translational control. Oncogene. 2002;21:6530-9 pubmed
    Over-expression studies have demonstrated that RALT (receptor associated late transducer) is a feedback inhibitor of ErbB-2 mitogenic and transforming signals...
  2. Anastasi S, Fiorentino L, Fiorini M, Fraioli R, Sala G, Castellani L, et al. Feedback inhibition by RALT controls signal output by the ErbB network. Oncogene. 2003;22:4221-34 pubmed
    The ErbB-2 interacting protein receptor-associated late transducer (RALT) was previously identified as a feedback inhibitor of ErbB-2 mitogenic signals...
  3. Makkinje A, Quinn D, Chen A, Cadilla C, Force T, Bonventre J, et al. Gene 33/Mig-6, a transcriptionally inducible adapter protein that binds GTP-Cdc42 and activates SAPK/JNK. A potential marker transcript for chronic pathologic conditions, such as diabetic nephropathy. Possible role in the response to persistent stres. J Biol Chem. 2000;275:17838-47 pubmed
    ..b>gene 33 (also called mitogen-inducible gene-6, mig-6) is an immediate early gene that is transcriptionally induced by a ..
  4. Hackel P, Gishizky M, Ullrich A. Mig-6 is a negative regulator of the epidermal growth factor receptor signal. Biol Chem. 2001;382:1649-62 pubmed
    ..Consistent with these findings, a possible role as tumor suppressor is indicated by Mig-6-mediated inhibition of EGFR overexpression-induced transformation of Rati cells. ..
  5. Ballaro C, Ceccarelli S, Tiveron C, Tatangelo L, Salvatore A, Segatto O, et al. Targeted expression of RALT in mouse skin inhibits epidermal growth factor receptor signalling and generates a Waved-like phenotype. EMBO Rep. 2005;6:755-61 pubmed
    ..Here, we report on the forced expression of RALT/MIG-6, a negative feedback regulator of ErbB receptors, in mouse skin...
  6. Zhang Y, Staal B, Su Y, Swiatek P, Zhao P, Cao B, et al. Evidence that MIG-6 is a tumor-suppressor gene. Oncogene. 2007;26:269-76 pubmed
    ..These data suggests that MIG-6 is a tumor-suppressor gene and is therefore a candidate gene for the frequent 1p36 genetic alterations found in lung cancer. ..
  7. Nagashima T, Ushikoshi Nakayama R, Suenaga A, Ide K, Yumoto N, Naruo Y, et al. Mutation of epidermal growth factor receptor is associated with MIG6 expression. FEBS J. 2009;276:5239-51 pubmed publisher
    ..signaling-related genes in a differentially expressed gene set, and significant protein expression of MIG6/RALT(ERRFI1), an EGFR negative regulator, was confirmed in L858R...
  8. Lin C, Du J, Shen W, Whang E, Donner D, Griff N, et al. Mitogen-inducible gene-6 is a multifunctional adaptor protein with tumor suppressor-like activity in papillary thyroid cancer. J Clin Endocrinol Metab. 2011;96:E554-65 pubmed publisher
    ..Mig-6 has tumor suppressor-like activity in PTC. In vivo studies are required to confirm that Mig-6 is a putative tumor suppressor in PTC, and future studies should investigate the utility of Mig-6 as a diagnostic marker. ..
  9. Guha U, Chaerkady R, Marimuthu A, Patterson A, Kashyap M, Harsha H, et al. Comparisons of tyrosine phosphorylated proteins in cells expressing lung cancer-specific alleles of EGFR and KRAS. Proc Natl Acad Sci U S A. 2008;105:14112-7 pubmed publisher
    ..Bayesian network analysis of these and other datasets revealed that PTRF might be a potentially important component of the ERBB signaling network. ..

More Information

Publications107 found, 100 shown here

  1. Ruan D, Warren R, Moalem J, Chung K, Griffin A, Shen W, et al. Mitogen-inducible gene-6 expression correlates with survival and is an independent predictor of recurrence in BRAF(V600E) positive papillary thyroid cancers. Surgery. 2008;144:908-13; discussion 913-4 pubmed publisher
    ..The purpose of this study was to determine if Mig-6 expression is associated with EGFR expression or surgical outcomes in PTC...
  2. Fiorentino L, Pertica C, Fiorini M, Talora C, Crescenzi M, Castellani L, et al. Inhibition of ErbB-2 mitogenic and transforming activity by RALT, a mitogen-induced signal transducer which binds to the ErbB-2 kinase domain. Mol Cell Biol. 2000;20:7735-50 pubmed
    The product of rat gene 33 was identified as an ErbB-2-interacting protein in a two-hybrid screen employing the ErbB-2 juxtamembrane and kinase domains as bait...
  3. Anastasi S, Sala G, Huiping C, Caprini E, Russo G, Iacovelli S, et al. Loss of RALT/MIG-6 expression in ERBB2-amplified breast carcinomas enhances ErbB-2 oncogenic potency and favors resistance to Herceptin. Oncogene. 2005;24:4540-8 pubmed
    ..Herein, we have addressed tumor suppression by RALT/MIG-6, a transcriptionally controlled feedback inhibitor of ErbB RTKs, in breast cancer cells...
  4. Reschke M, Ferby I, Stepniak E, Seitzer N, Horst D, Wagner E, et al. Mitogen-inducible gene-6 is a negative regulator of epidermal growth factor receptor signaling in hepatocytes and human hepatocellular carcinoma. Hepatology. 2010;51:1383-90 pubmed publisher
    ..Our data implicate mig-6 as a regulator of EGFR activity in hepatocytes and as a suppressor of EGFR signaling in human liver cancer. ..
  5. Zhang Y, Vande Woude G. Mig-6, signal transduction, stress response and cancer. Cell Cycle. 2007;6:507-13 pubmed
  6. Zhang X, Pickin K, Bose R, Jura N, Cole P, Kuriyan J. Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface. Nature. 2007;450:741-4 pubmed
    ..The cytoplasmic protein MIG6 (mitogen-induced gene 6; also known as ERRFI1) interacts with and inhibits the kinase domains of EGFR and ERBB2 (refs 3-5)...
  7. Ying H, Zheng H, Scott K, Wiedemeyer R, Yan H, Lim C, et al. Mig-6 controls EGFR trafficking and suppresses gliomagenesis. Proc Natl Acad Sci U S A. 2010;107:6912-7 pubmed publisher
    ..In GBM, the highly frequent loss of Mig-6 would therefore serve to sustain aberrant EGFR-mediated oncogenic signaling. Together, these data uncover a unique tumor suppression mechanism involving the regulation of receptor trafficking. ..
  8. Frosi Y, Anastasi S, Ballaro C, Varsano G, Castellani L, Maspero E, et al. A two-tiered mechanism of EGFR inhibition by RALT/MIG6 via kinase suppression and receptor degradation. J Cell Biol. 2010;189:557-71 pubmed publisher
    ..Receptor-associated late transducer (RALT) is a feedback inhibitor of EGFR whose genetic ablation in the mouse causes phenotypes due to EGFR-driven excess ..
  9. Xu D, Makkinje A, Kyriakis J. Gene 33 is an endogenous inhibitor of epidermal growth factor (EGF) receptor signaling and mediates dexamethasone-induced suppression of EGF function. J Biol Chem. 2005;280:2924-33 pubmed
    We report a mechanism by which the adapter protein Gene 33 (also called RALT and MIG6) regulates epidermal growth factor receptor (EGFR) signaling...
  10. Anastasi S, Baietti M, Frosi Y, Alema S, Segatto O. The evolutionarily conserved EBR module of RALT/MIG6 mediates suppression of the EGFR catalytic activity. Oncogene. 2007;26:7833-46 pubmed
    ..Increasing attention is being drawn on transcriptionally controlled feedback inhibitors of EGFR, namely RALT/MIG6, LRIG1, SOCS4 and SOCS5...
  11. Jeong J, Lee H, Lee K, White L, Broaddus R, Zhang Y, et al. Mig-6 modulates uterine steroid hormone responsiveness and exhibits altered expression in endometrial disease. Proc Natl Acad Sci U S A. 2009;106:8677-82 pubmed publisher
    ..Since Mig-6 is regulated by both PR and SRC-1, this identifies a PR, SRC-1, Mig-6 regulatory pathway that is critical in the suppression of endometrial cancer. ..
  12. Ajiro M, Jia R, Yang Y, Zhu J, Zheng Z. A genome landscape of SRSF3-regulated splicing events and gene expression in human osteosarcoma U2OS cells. Nucleic Acids Res. 2016;44:1854-70 pubmed publisher in human osteosarcoma U2OS cells, we found that SRSF3 regulates the expression of 60 genes including ERRFI1, ANXA1 and TGFB2, and 182 splicing events in 164 genes, including EP300, PUS3, CLINT1, PKP4, KIF23, CHK1, SMC2, ..
  13. Shepard J, Jeong J, Maihle N, O Brien S, Dealy C. Transient anabolic effects accompany epidermal growth factor receptor signal activation in articular cartilage in vivo. Arthritis Res Ther. 2013;15:R60 pubmed
  14. Kim S, Shin Y, Kim Y, Jang S, Ku J. Identification of genes inducing resistance to ionizing radiation in human rectal cancer cell lines: re-sensitization of radio-resistant rectal cancer cells through down regulating NDRG1. BMC Cancer. 2018;18:594 pubmed publisher
    ..A microarray analysis indicated the RNA expression of five genes (NDRG1, ERRFI1, H19, MPZL3, and UCA1) was highly increased in radio-resistant rectal cancer cell lines...
  15. Dong N, Zhang K, Wu L, Hong H. Right Anterolateral Minithoracotomy versus Median Sternotomy Approach for Resection of Left Atrial Myxoma. Thorac Cardiovasc Surg. 2018;66:193-197 pubmed publisher
    ..In this retrospective study, we compared right anterolateral minithoracotomy (RALT) with standard median sternotomy (SMS) for resection of left atrial myxoma (LAM)...
  16. Xie B, Zhao L, Chen H, Jin B, Mao Z, Yao Z. The mitogen-inducible gene-6 is involved in regulation of cellular senescence in normal diploid fibroblasts. Biol Cell. 2013;105:488-99 pubmed publisher
    ..Mig-6 induces premature senescence via functioning in regulation of cellular senescence in normal diploid fibroblasts. ..
  17. Anastasi S, Lamberti D, Alemà S, Segatto O. Regulation of the ErbB network by the MIG6 feedback loop in physiology, tumor suppression and responses to oncogene-targeted therapeutics. Semin Cell Dev Biol. 2016;50:115-24 pubmed publisher
    ..This review focuses on MIG6, an IFI that restrains ErbB signaling by mediating ErbB kinase suppression and receptor down-regulation...
  18. Donner D, Ruan D, Toriguchi K, Bergsland E, Nakakura E, Lin M, et al. Mitogen Inducible Gene-6 Is a Prognostic Marker for Patients with Colorectal Liver Metastases. Transl Oncol. 2019;12:550-560 pubmed publisher
    ..MIG-6 expression is inversely associated with survival after hepatectomy and may be used to improve traditional prognostic schemes that rely on clinicopathologic data such as the Clinical Risk Score. ..
  19. Yoo J, Kang H, Broaddus R, Risinger J, Choi K, Kim T. MIG-6 suppresses endometrial epithelial cell proliferation by inhibiting phospho-AKT. BMC Cancer. 2018;18:605 pubmed publisher
    ..This information may help guide more effective non-surgical interventions in the future. ..
  20. Pest M, Russell B, Zhang Y, Jeong J, Beier F. Disturbed cartilage and joint homeostasis resulting from a loss of mitogen-inducible gene 6 in a mouse model of joint dysfunction. Arthritis Rheumatol. 2014;66:2816-27 pubmed publisher
    ..Whole-body knockout of the Mig6 gene in mice has been shown to induce osteoarthritis and joint degeneration...
  21. Park B, Lee E, Kim H, Lee J, Kim K, Jeong W, et al. Fatty Liver and Insulin Resistance in the Liver-Specific Knockout Mice of Mitogen Inducible Gene-6. J Diabetes Res. 2016;2016:1632061 pubmed publisher
  22. Lwande O, Bucht G, Ahlm C, Ahlm K, Näslund J, Evander M. Mosquito-borne Inkoo virus in northern Sweden - isolation and whole genome sequencing. Virol J. 2017;14:61 pubmed publisher
    ..INKV is frequently circulating in northern Sweden and Ae. communis is the key vector. The high mutation rate of the INKV M segment may have consequences on virulence. ..
  23. Jin N, Cho S, Raso M, Wistuba I, Smith Y, Yang Y, et al. Mig-6 is required for appropriate lung development and to ensure normal adult lung homeostasis. Development. 2009;136:3347-56 pubmed publisher
    Mitogen-inducible gene 6 [Mig-6; Errfi1 (ErbB receptor feedback inhibitor 1); RALT (receptor-associated late transducer); gene 33] is a ubiquitously expressed adaptor protein containing CRIB, SH3 and 14-3-3 interacting domains and has ..
  24. Kim T, Lee D, Franco H, Lydon J, Jeong J. ERBB receptor feedback inhibitor 1 regulation of estrogen receptor activity is critical for uterine implantation in mice. Biol Reprod. 2010;82:706-13 pubmed publisher
    ..In previous studies, we have identified ERBB receptor feedback inhibitor 1 (Errfi1) as a downstream target of Pgr action in the uterus...
  25. Kim T, Yoo J, Kim H, Gilbert J, Ku B, Li J, et al. Mig-6 suppresses endometrial cancer associated with Pten deficiency and ERK activation. Cancer Res. 2014;74:7371-82 pubmed publisher
  26. Li Z, Chen P, Su R, Li Y, Hu C, Wang Y, et al. Overexpression and knockout of miR-126 both promote leukemogenesis. Blood. 2015;126:2005-15 pubmed publisher
    ..are highly expressed in LSCs/LICs and/or primitive hematopoietic stem/progenitor cells, likely through targeting ERRFI1 and SPRED1, whereas miR-126 knockout activates genes that are highly expressed in committed, more differentiated ..
  27. Wang W, Zheng Y, Wang M, Yan M, Jiang J, Li Z. Exosomes derived miR-126 attenuates oxidative stress and apoptosis from ischemia and reperfusion injury by targeting ERRFI1. Gene. 2019;690:75-80 pubmed publisher
    ..miR-126 also improved the cardiac function in vivo. Luciferase activity revealed that miR-126 could bind to ERRFI1, suggesting miR-126 functioned through regulating ERRFI1...
  28. Yoo J, Kim T, Kong S, Lee J, Choi W, Kim K, et al. Role of Mig-6 in hepatic glucose metabolism. J Diabetes. 2016;8:86-97 pubmed publisher
    ..This is the first report of Mig-6 involvement in hepatic insulin resistance and a new mechanism that explains hepatic insulin resistance. ..
  29. Lee J, Park B, Choung S, Kim J, Joung K, Lee J, et al. Amelioration of hypercholesterolemia by an EGFR tyrosine kinase inhibitor in mice with liver-specific knockout of Mig-6. PLoS ONE. 2014;9:e114782 pubmed publisher
  30. Lin C, Barletta J, Nehs M, Morris Z, Donner D, Whang E, et al. Thyroid-specific knockout of the tumor suppressor mitogen-inducible gene 6 activates epidermal growth factor receptor signaling pathways and suppresses nuclear factor-κB activity. Surgery. 2011;150:1295-302 pubmed publisher
    ..We suggest that the loss of Mig-6 alters the membrane distribution of EGFR, which may limit receptor degradation and activate this oncogenic signaling pathway. ..
  31. Mete E, Kaleli I, Cevahir N, Demir M, Akkaya Y, Kiriş Satılmış O. [Evaluation of virulence factors in enterococcus species]. Mikrobiyol Bul. 2017;51:101-114 pubmed
    ..It should be kept in mind that VRE can causeinfections which are difficult-to-treat especially in hospitalized patients and VSE have significant virulence factors that can cause severe infections. ..
  32. Wendt M, Williams W, Pascuzzi P, Balanis N, Schiemann B, Carlin C, et al. The antitumorigenic function of EGFR in metastatic breast cancer is regulated by expression of Mig6. Neoplasia. 2015;17:124-33 pubmed publisher
    ..of EGFR through EMT and metastasis we demonstrate that the EGFR inhibitory molecule, Mitogen Induced Gene-6 (Mig6), is tumor suppressive in in situ tumor cells...
  33. Lee J, Choung S, Kim J, Lee J, Kim K, Kim H, et al. Mig-6 gene knockout induces neointimal hyperplasia in the vascular smooth muscle cell. Dis Markers. 2014;2014:549054 pubmed publisher
    ..This finding provides new insight into the development of more effective ways to treat and prevent neointimal hyperplasia, particularly in-stent restenosis after percutaneous vascular intervention. ..
  34. Kim T, Yoo J, Jeong J. Mig-6 Mouse Model of Endometrial Cancer. Adv Exp Med Biol. 2017;943:243-259 pubmed
    ..Mitogen inducible gene 6 (Mig-6, Errfi1, RALT, or gene 33) is an immediate early response gene that can be induced by various mitogens and common chronic stress stimuli...
  35. Fang G, Fan X, Shen F. The relationship between polymorphisms of interleukin-4 gene and silicosis. Biomed Environ Sci. 2011;24:678-82 pubmed publisher
    ..7% and in the controls were 69.4%, 4.1%, and 26.4%. The differences were significant (P=0.034). The relationship between genetic polymorphism of IL-4-33 site and silicosis has been found and -33TT is a protective genotype for silicosis. ..
  36. Liu J, Cho S, Akkanti B, Jin N, Mao J, Long W, et al. ErbB2 Pathway Activation upon Smad4 Loss Promotes Lung Tumor Growth and Metastasis. Cell Rep. 2015;10:1599-1613 pubmed publisher
    ..determine that loss of PTEN and SMAD4 results in ELF3 and ErbB2 pathway activation due to decreased expression of ERRFI1, a negative regulator of ERBB2 in mouse and human cells...
  37. Sasaki M, Terabayashi T, Weiss S, Ferby I. The Tumor Suppressor MIG6 Controls Mitotic Progression and the G2/M DNA Damage Checkpoint by Stabilizing the WEE1 Kinase. Cell Rep. 2018;24:1278-1289 pubmed publisher
    b>MIG6 is an important tumor suppressor that binds to and negatively regulates epidermal growth factor receptor (EGFR). Here, we report an EGFR-independent function for MIG6 as an integral component of the cell cycle machinery...
  38. Siu A, Virtanen C, Jongstra J. PIM kinase isoform specific regulation of MIG6 expression and EGFR signaling in prostate cancer cells. Oncotarget. 2011;2:1134-44 pubmed
    ..We then focused on the M-110 induced up regulation of the MIG6 gene that encodes a negative regulator of EGFR signaling...
  39. Migliore C, Morando E, Ghiso E, Anastasi S, Leoni V, Apicella M, et al. miR-205 mediates adaptive resistance to MET inhibition via ERRFI1 targeting and raised EGFR signaling. EMBO Mol Med. 2018;10: pubmed publisher
    ..MiRNA profiling combined with RNA-Seq in MET-addicted cancer cell lines led us to identify the miR-205/ERRFI1 (ERBB receptor feedback inhibitor-1) axis as a novel mediator of resistance to MET tyrosine kinase inhibitors (..
  40. Zhang X, Shang Guan Y, Ma J, Hu H, Wang L, Magdalou J, et al. Mitogen-inducible gene-6 partly mediates the inhibitory effects of prenatal dexamethasone exposure on endochondral ossification in long bones of fetal rats. Br J Pharmacol. 2016;173:2250-62 pubmed publisher
    ..In addition, the mitogen-inducible gene-6 (Mig6) and osteoprotegerin (OPG) expression were stimulated, and the receptor activator of NF-?B ligand (RANKL) ..
  41. Niu N, Xiang J, Yang Q, Wang L, Wei Z, Chen L, et al. RNA-binding protein SAMD4 regulates skeleton development through translational inhibition of Mig6 expression. Cell Discov. 2017;3:16050 pubmed publisher
    ..Mechanism study demonstrates that SAMD4 binds the Mig6 mRNA and inhibits MIG6 protein synthesis...
  42. Cairns J, Fridley B, Jenkins G, Zhuang Y, Yu J, Wang L. Differential roles of ERRFI1 in EGFR and AKT pathway regulation affect cancer proliferation. EMBO Rep. 2018;19: pubmed publisher
    ..Here, we present a dual mechanism of AKT regulation by the ERBB receptor feedback inhibitor 1 (ERRFI1)...
  43. Tong J, Taylor P, Peterman S, Prakash A, Moran M. Epidermal growth factor receptor phosphorylation sites Ser991 and Tyr998 are implicated in the regulation of receptor endocytosis and phosphorylations at Ser1039 and Thr1041. Mol Cell Proteomics. 2009;8:2131-44 pubmed publisher
    ..This reinforces the notion that EGFR function is manifest through spatially and temporally controlled protein-protein interactions and phosphorylations. ..
  44. Yoo J, Kim T, Lee J, Dunwoodie S, Ku B, Jeong J. Mig-6 regulates endometrial genes involved in cell cycle and progesterone signaling. Biochem Biophys Res Commun. 2015;462:409-14 pubmed publisher
    ..Identification and analysis of these responsive genes will help define the role of P4 as well as Mig-6 in regulating uterine biology. ..
  45. Yu X, Yang R, Leng C. Truncation, modification, and optimization of MIG6(segment 2) peptide to target lung cancer-related EGFR. Comput Biol Chem. 2016;61:251-7 pubmed publisher
    ..The tumor-suppressor protein MIG6 is a negative regulator of EGFR, which can bind at the activation interface of asymmetric dimer of EGFR kinase ..
  46. Maity T, Venugopalan A, Linnoila I, Cultraro C, Giannakou A, Nemati R, et al. Loss of MIG6 Accelerates Initiation and Progression of Mutant Epidermal Growth Factor Receptor-Driven Lung Adenocarcinoma. Cancer Discov. 2015;5:534-49 pubmed publisher
    Somatic mutations in the EGFR kinase domain drive lung adenocarcinoma. We have previously identified MIG6, an inhibitor of ERBB signaling and a potential tumor suppressor, as a target for phosphorylation by mutant EGFRs...
  47. Park S, Li C, Zhao H, Darzynkiewicz Z, Xu D. Gene 33/Mig6 inhibits hexavalent chromium-induced DNA damage and cell transformation in human lung epithelial cells. Oncotarget. 2016;7:8916-30 pubmed publisher
    ..In this study, we investigated the potential role of Gene 33 (ERRFI1, Mig6), a multifunctional adaptor protein, in Cr(VI)-mediated lung carcinogenesis...
  48. Sun M, Cai J, Anderson R, Sun Y. Type I ? Phosphatidylinositol Phosphate 5-Kinase i5 Controls the Ubiquitination and Degradation of the Tumor Suppressor Mitogen-inducible Gene 6. J Biol Chem. 2016;291:21461-21473 pubmed
    Mitogen-inducible gene 6 (Mig6) is a tumor suppressor, and the disruption of Mig6 expression is associated with cancer development...
  49. Mbarek I, Mdimeg S, Moussa A, Zellama D, Kaarout H, Abdelmoula J, et al. Unusual clinical outcome of primary Hyperoxaluria type 1 in Tunisian patients carrying 33_34InsC mutation. BMC Nephrol. 2017;18:195 pubmed publisher
    ..31 years old. In this study 33-34InsC mutation gives a controversial clinical effect in children and adults. The implication of other genetic and/or environmental factors can play a crucial role in determining the ultimate phenotype. ..
  50. Zhang Y, Zheng Q. Exploring the interactions of EGFR with phosphorylated Mig6 by molecular dynamics simulations and MM-PBSA calculations. J Theor Biol. 2018;447:118-125 pubmed publisher
    b>Mig6, a negative regulator, directly binds to epidermal growth factor receptor (EGFR), including Mig6-segment1 and Mig6-segment2. Mig6 requires phosphorylation of Y394 on Mig6-segment2 in order to inhibit EGFR...
  51. Lee I, Lee J, Kim H, Lee J, Lee S, Kim H, et al. Novel ERBB receptor feedback inhibitor 1 (ERRFI1) + 808 T/G polymorphism confers protective effect on diabetic nephropathy in a Korean population. Dis Markers. 2013;34:113-24 pubmed publisher
    The identification and characterization of the gene, ERRFI1, in diabetes has not been reported. In this study, we evaluated the relationship between ERRFI1 polymorphism and characteristics of type 2 diabetes mellitus (T2DM) in Korea...
  52. Wang H, Pan J, Luo L, Ning X, Ye Z, Yu Z, et al. NF-κB induces miR-148a to sustain TGF-β/Smad signaling activation in glioblastoma. Mol Cancer. 2015;14:2 pubmed publisher
    ..The association between an RNA-induced silencing complex and QKI, mitogen-inducible gene 6 (MIG6), S-phase kinase-associated protein 1 (SKP1), and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) mRNA was tested ..
  53. Miao Y, Cui L, Chen Z, Zhang L. Gene expression profiling of DMU-212-induced apoptosis and anti-angiogenesis in vascular endothelial cells. Pharm Biol. 2016;54:660-6 pubmed publisher
    ..TMEM217, DUSP8, and SPRY4), chromosome organization (HIST1H2BH and GEM), cell migration and angiogenesis (ERRFI1, HBEGF, and NEDD9), and apoptosis (TNFSF15, TNFRSF9, CD274, BCL2L11, BIRC3, TNFAIP3, and TIFA), as well as other ..
  54. Li F, Liu Y, Miao X, Fu G, Curry T. Expression and regulation of the differentiation regulators ERBB Receptor Feedback Inhibitor 1 (ERRFI1) and Interferon-related Developmental Regulator 1 (IFRD1) during the periovulatory period in the rat ovary. Mol Reprod Dev. 2016;83:714-23 pubmed publisher
    The current study investigated the regulation and the spatiotemporal expression pattern of Errfi1 and Ifrd1, genex encoding factors that regulate differentiation and cessation of cell division, in the rat ovary during the periovulatory ..
  55. Zhang X, Maity T, Kashyap M, Bansal M, Venugopalan A, Singh S, et al. Quantitative Tyrosine Phosphoproteomics of Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitor-treated Lung Adenocarcinoma Cells Reveals Potential Novel Biomarkers of Therapeutic Response. Mol Cell Proteomics. 2017;16:891-910 pubmed publisher
    ..lines include sites on kinases, such as EGFR-Y1197 and MAPK7-Y221, and adaptor proteins, such as SHC1-Y349/350, ERRFI1-Y394, GAB1-Y689, STAT5A-Y694, DLG3-Y705, and DAPP1-Y139, suggesting these are potential biomarkers of TKI ..
  56. Ando H, Miyamoto T, Kashima H, Higuchi S, Ida K, Mvunta D, et al. Panobinostat Enhances Growth Suppressive Effects of Progestin on Endometrial Carcinoma by Increasing Progesterone Receptor and Mitogen-Inducible Gene-6. Horm Cancer. 2017;8:257-267 pubmed publisher
    ..In the present study, we examined the involvement of mitogen-inducible gene-6 (MIG6), a negative regulator of the EGF receptor, in the progestin-mediated growth suppression of endometrial epithelia...
  57. Chao Y, Tain Y, Leu S, Wu K, Lee W, Chan J. Developmental programming of the metabolic syndrome: Next-generation sequencing analysis of transcriptome expression in a rat model of maternal high fructose intake. Sheng Li Xue Bao. 2016;68:557-567 pubmed
    ..Different organs do not respond similarly to maternal HF intake. We found that changes in expression of Errfi1 and Ctgf were shared by four organs at 1 day of age...
  58. Lafont J, Talma S, Hopfgarten C, Murphy C. Hypoxia promotes the differentiated human articular chondrocyte phenotype through SOX9-dependent and -independent pathways. J Biol Chem. 2008;283:4778-86 pubmed
    ..Of special note, we report new hypoxia-inducible and SOX9-regulated genes, Gdf10 and Chm-I. In addition, Mig6 and InhbA were induced by hypoxia, predominantly via HIF-2alpha, but were not regulated by SOX9...
  59. Chang X, Izumchenko E, Solis L, Kim M, Chatterjee A, Ling S, et al. The relative expression of Mig6 and EGFR is associated with resistance to EGFR kinase inhibitors. PLoS ONE. 2013;8:e68966 pubmed publisher the EGFR tyrosine kinase inhibitor (TKI) erlotinib, with a concomitant increase of mitogen-inducible gene 6 (Mig6), a negative regulator of EGFR through the upregulation of the PI3K-AKT pathway...
  60. Deng Y, Li J. Rational Optimization of Tumor Suppressor-Derived Peptide Inhibitor Selectivity between Oncogene Tyrosine Kinases ErbB1 and ErbB2. Arch Pharm (Weinheim). 2017;: pubmed publisher
    ..5- and 1.6-fold, respectively). The method is expected to be used for the rational molecular design of selective peptide entities for other protein systems...
  61. Juszczak G, Stankiewicz A. Glucocorticoids, genes and brain function. Prog Neuropsychopharmacol Biol Psychiatry. 2018;82:136-168 pubmed publisher
    ..The most frequently reported genes were Errfi1 and Ddit4...
  62. Yoon Y, Kim H, Song S, Han S, Oh D, Im S, et al. Down-regulation of mitogen-inducible gene 6, a negative regulator of EGFR, enhances resistance to MEK inhibition in KRAS mutant cancer cells. Cancer Lett. 2012;316:77-84 pubmed publisher
    ..We found that treatment with AZD6244 reduced the expression of mitogen-inducible gene 6 (MIG6), a negative feedback regulator for EGFR, in AZD6244-resistant cells, while activity of EGFR and AKT was increased ..
  63. Gajiwala K, Feng J, Ferre R, Ryan K, Brodsky O, Weinrich S, et al. Insights into the aberrant activity of mutant EGFR kinase domain and drug recognition. Structure. 2013;21:209-19 pubmed publisher
    ..Biochemical and biophysical evidence suggest that the oncogenic mutations impact the conformational dynamics of the enzyme. ..
  64. Jiang X, Niu M, Chen D, Chen J, Cao Y, Li X, et al. Inhibition of Cdc42 is essential for Mig-6 suppression of cell migration induced by EGF. Oncotarget. 2016;7:49180-49193 pubmed publisher
    ..Together, our results demonstrate that Mig-6 inhibition of Cdc42 signaling is critical in Mig-6 function to suppress cell migration and that dysregulation of this pathway may play a critical role in cancer development. ..
  65. Keeton A, Messina J. Modulation of Elk-dependent-transcription by Gene33. J Cell Biochem. 2005;94:1190-8 pubmed
    ..These findings suggest that Gene33 may increase ERK activity, and that the C-terminal half of Gene33 may act less specifically in the absence of the N-terminal half, inducing JNK activity. ..
  66. Arroyo R, Suñé G, Zanzoni A, Duran Frigola M, Alcalde V, Stracker T, et al. Systematic identification of molecular links between core and candidate genes in breast cancer. J Mol Biol. 2015;427:1436-50 pubmed publisher
    ..Overall, our BC-related network may serve as a framework to integrate clinical and molecular data and foster novel global therapeutic strategies. ..
  67. Vu H, Rosenbaum S, Capparelli C, Purwin T, Davies M, Berger A, et al. MIG6 Is MEK Regulated and Affects EGF-Induced Migration in Mutant NRAS Melanoma. J Invest Dermatol. 2016;136:453-463 pubmed publisher v-akt murine thymoma viral oncogene homolog signaling and decreased expression of mitogen-inducible gene 6 (MIG6), a negative regulator of epidermal growth factor receptor/v-erb-b2 erythroblastic leukemia viral oncogene homolog ..
  68. Li Z, Qu L, Luo W, Tian Y, Zhai H, Xu K, et al. Mig-6 is down-regulated in HCC and inhibits the proliferation of HCC cells via the P-ERK/Cyclin D1 pathway. Exp Mol Pathol. 2017;102:492-499 pubmed publisher
    ..These results indicate that Mig-6 expression is low in HCC, which predicts a poor prognosis. Mig-6 may regulate cell proliferation and the cell cycle through the P-ERK/Cyclin D1 pathway. ..
  69. Park S, Zhang X, Li C, Yin C, Li J, Fallon J, et al. Single-cell RNA sequencing reveals an altered gene expression pattern as a result of CRISPR/cas9-mediated deletion of Gene 33/Mig6 and chronic exposure to hexavalent chromium in human lung epithelial cells. Toxicol Appl Pharmacol. 2017;330:30-39 pubmed publisher
    b>Gene 33 (Mig6, ERRFI1) is an adaptor protein with multiple cellular functions. We recently reported that depletion of this protein promotes lung epithelial cell transformation induced by hexavalent chromium [Cr(VI)]...
  70. Mahalakshmi R, Maurya S, Burdak B, Surti P, Patel M, Jain V. Structural plasticity of T4 transcription co-activator gp33 revealed by a protease-resistant unfolded state. Biochem Biophys Res Commun. 2017;492:61-66 pubmed publisher
    b>Gene 33 protein (gp33) is a transcriptional coactivator for late genes of the T4 bacteriophage. gp33 possesses a 5-helix bundle core, with unstructured N- and C-terminal regions that account for >50% of the protein sequence...
  71. Hohos N, Cho K, Swindle D, Skaznik Wikiel M. High-fat diet exposure, regardless of induction of obesity, is associated with altered expression of genes critical to normal ovulatory function. Mol Cell Endocrinol. 2018;470:199-207 pubmed publisher
    ..05). Several of these 25 genes are involved in normal ovarian functions, including ovulation (Edn2, Tnfaip6, Errfi1, Prkg2, and Nfil3), luteinization (Edn2), and luteolysis (Nr4a1)...
  72. Wick M, Burger C, Funk M, Muller R. Identification of a novel mitogen-inducible gene (mig-6): regulation during G1 progression and differentiation. Exp Cell Res. 1995;219:527-35 pubmed
    ..As a first step toward a functional characterization we show that the Mig-6 polypeptide is located in the cytoplasm. ..
  73. Milewska M, Kolch W. Mig-6 participates in the regulation of cell senescence and retinoblastoma protein phosphorylation. Cell Signal. 2014;26:1870-7 pubmed publisher
    ..We further show that Mig-6 overexpression reduces B-Raf V600E mediated pRb inactivation and preserves pRb function. ..
  74. Li Z, Qu L, Wen H, Zhong H, Xu K, Qiu X, et al. Mig-6 overcomes gefitinib resistance by inhibiting EGFR/ERK pathway in non-small cell lung cancer cell lines. Int J Clin Exp Pathol. 2014;7:7304-11 pubmed
    ..Our work uncovered that Mig-6 may be an effective therapeutic target in gefitinib-resistant lung cancer patients. ..
  75. Xu W, Zhu S, Zhou Y, Jin Y, Dai H, Wang X. Upregulation of mitogen-inducible gene 6 triggers antitumor effect and attenuates progesterone resistance in endometrial carcinoma cells. Cancer Gene Ther. 2015;22:536-41 pubmed publisher
    ..Therefore, upregulation of Mig-6 may add a new strategy to suppress endometrial tumorigenesis and attenuate the progesterone resistance during P4 treatment. ..
  76. Shangguan Y, Jiang H, Pan Z, Xiao H, Tan Y, Tie K, et al. Glucocorticoid mediates prenatal caffeine exposure-induced endochondral ossification retardation and its molecular mechanism in female fetal rats. Cell Death Dis. 2017;8:e3157 pubmed publisher
  77. Boopathy G, Lynn J, Wee S, Gunaratne J, Hong W. Phosphorylation of Mig6 negatively regulates the ubiquitination and degradation of EGFR mutants in lung adenocarcinoma cell lines. Cell Signal. 2018;43:21-31 pubmed publisher
    ..Using SILAC phosphoproteomic approach, we identify that Mig6 is highly phosphorylated at S256 in EGFR mutants (19del and L858R)...
  78. Kim J, Zhang Y, Skalski M, Hayes J, Kefas B, Schiff D, et al. microRNA-148a is a prognostic oncomiR that targets MIG6 and BIM to regulate EGFR and apoptosis in glioblastoma. Cancer Res. 2014;74:1541-53 pubmed publisher
    ..Two direct targets of miR-148a were identified, the EGF receptor (EGFR) regulator MIG6 and the apoptosis regulator BIM, which rescue experiments showed were essential to mediate the oncogenic activity ..
  79. Milewska M, Romano D, Herrero A, Guerriero M, Birtwistle M, Quehenberger F, et al. Mitogen-Inducible Gene-6 Mediates Feedback Inhibition from Mutated BRAF towards the Epidermal Growth Factor Receptor and Thereby Limits Malignant Transformation. PLoS ONE. 2015;10:e0129859 pubmed publisher
    ..Taken together, we demonstrate that MIG-6 efficiently reduces cellular transformation driven by oncogenic BRAF by orchestrating a negative feedback circuit directed towards the EGFR. ..
  80. Park S, Choi H, Seo J, Yoo J, Jeong J, Choi Y, et al. DNAJB1 negatively regulates MIG6 to promote epidermal growth factor receptor signaling. Biochim Biophys Acta. 2015;1853:2722-30 pubmed publisher
    Mitogen-inducible gene 6 (MIG6) is a tumor suppressor implicated in the development of human cancers; however, the regulatory mechanisms of MIG6 remain unknown...
  81. Naruo Y, Nagashima T, Ushikoshi Nakayama R, Saeki Y, Nakakuki T, Naka T, et al. Epidermal growth factor receptor mutation in combination with expression of MIG6 alters gefitinib sensitivity. BMC Syst Biol. 2011;5:29 pubmed publisher
    ..We predicted and experimentally verified that Mig6, which is a known negative regulator of EGFR and specifically expressed in H1299L858R cells, synergized with ..
  82. Li Z, Qu L, Zhong H, Xu K, Qiu X, Wang E. Low expression of Mig-6 is associated with poor survival outcome in NSCLC and inhibits cell apoptosis via ERK-mediated upregulation of Bcl-2. Oncol Rep. 2014;31:1707-14 pubmed publisher
    ..Collectively, our results showed that Mig-6 is a potential biomarker for evaluation of tumor prognosis of lung cancer. Mig-6 promotes apoptosis in lung cancer cells via the ERK pathway. ..
  83. Endo H, Okami J, Okuyama H, Nishizawa Y, Imamura F, Inoue M. The induction of MIG6 under hypoxic conditions is critical for dormancy in primary cultured lung cancer cells with activating EGFR mutations. Oncogene. 2017;36:2824-2834 pubmed publisher
    ..In terms of mechanism, we found that a negative regulator of ERBB signaling, MIG6/ERRFI1/RALT/Gene33, was induced by hypoxia both in vitro and in vivo...
  84. Li C, Park S, Zhang X, Eisenberg L, Zhao H, Darzynkiewicz Z, et al. Nuclear Gene 33/Mig6 regulates the DNA damage response through an ATM serine/threonine kinase-dependent mechanism. J Biol Chem. 2017;292:16746-16759 pubmed publisher
    b>Gene 33 (Mig6, ERRFI1) is an adaptor protein with multiple cellular functions. We recently linked Gene 33 to the DNA damage response (DDR) induced by hexavalent chromium (Cr(VI)), but the molecular mechanism remains unknown...
  85. Liu F, Chen Y, Zhu G, Hysi P, Wu S, Adhikari K, et al. Meta-analysis of genome-wide association studies identifies 8 novel loci involved in shape variation of human head hair. Hum Mol Genet. 2017;: pubmed publisher
    ..A meta-analysis of three European GWASs identified 8 novel loci (1p36.23 ERRFI1/SLC45A1, 1p36.22 PEX14, 1p36.13 PADI3, 2p13.3 TGFA, 11p14.1 LGR4, 12q13.13 HOXC13, 17q21.2 KRTAP, and 20q13...
  86. Tsunoda T, Inokuchi J, Baba I, Okumura K, Naito S, Sasazuki T, et al. A novel mechanism of nuclear factor kappaB activation through the binding between inhibitor of nuclear factor-kappaBalpha and the processed NH(2)-terminal region of Mig-6. Cancer Res. 2002;62:5668-71 pubmed
    ..This novel NFkappaB activation pathway provides new insights regarding tumorigenesis, and the specific inhibition of the cleavage of Mig-6 may be a target for clinical treatment. ..
  87. Liu N, Matsumoto M, Kitagawa K, Kotake Y, Suzuki S, Shirasawa S, et al. Chk1 phosphorylates the tumour suppressor Mig-6, regulating the activation of EGF signalling. EMBO J. 2012;31:2365-77 pubmed publisher
    ..Our results suggest that Chk1 phosphorylates Mig-6 on Ser 251, resulting in the inhibition of Mig-6, and that Chk1 acts as a positive regulator of EGF signalling. This is a novel function of Chk1. ..
  88. Zhang Y, Staal B, Dykema K, Furge K, Vande Woude G. Cancer-type regulation of MIG-6 expression by inhibitors of methylation and histone deacetylation. PLoS ONE. 2012;7:e38955 pubmed publisher
    ..Furthermore, our data also suggest that MIG-6 gene expression is differentially regulated in lung cancer and melanoma. ..
  89. Colvin E, Ma H, Chen Y, Hernandez A, Fueger P. Glucocorticoid-induced suppression of ?-cell proliferation is mediated by Mig6. Endocrinology. 2013;154:1039-46 pubmed publisher
    ..factor and negative regulator of epidermal growth factor receptor signaling, Mig6 (also known as gene 33, RALT, and Errfi1)...
  90. Izumchenko E, Chang X, Michailidi C, Kagohara L, Ravi R, Paz K, et al. The TGF?-miR200-MIG6 pathway orchestrates the EMT-associated kinase switch that induces resistance to EGFR inhibitors. Cancer Res. 2014;74:3995-4005 pubmed publisher
    ..inhibition of the microRNAs 200 (miR200) family results in upregulated expression of the mitogen-inducible gene 6 (MIG6), a negative regulator of EGFR...
  91. Chrapkiewicz N, Davis C, Chu D, Caldwell C, Granner D. Rat gene 33: analysis of its structure, messenger RNA and basal promoter activity. Nucleic Acids Res. 1989;17:6651-67 pubmed
    Several overlapping cDNA and genomic DNA clones corresponding to mRNA g33 and gene 33, respectively, were isolated and characterized...
  92. Pao Chun L, Chan P, Chan W, Manser E. Cytoplasmic ACK1 interaction with multiple receptor tyrosine kinases is mediated by Grb2: an analysis of ACK1 effects on Axl signaling. J Biol Chem. 2009;284:34954-63 pubmed publisher
    ..kinases requires a C-terminal region that demonstrates a significant homology to the EGFR binding domain of MIG6. In this study, we have identified additional receptor tyrosine kinases, including Axl, leukocyte tyrosine kinase, ..