Gene Symbol: ERp57
Description: protein disulfide isomerase family A member 3
Alias: ER60, ERp57, ERp60, ERp61, GRP57, GRP58, HEL-S-269, HEL-S-93n, HsT17083, P58, PI-PLC, protein disulfide-isomerase A3, 58 kDa glucose-regulated protein, 58 kDa microsomal protein, ER protein 57, ER protein 60, disulfide isomerase ER-60, endoplasmic reticulum P58, endoplasmic reticulum resident protein 57, endoplasmic reticulum resident protein 60, epididymis secretory protein Li 269, epididymis secretory sperm binding protein Li 93n, glucose regulated protein, 58kDa, phospholipase C-alpha, protein disulfide isomerase-associated 3
Species: human
Products:     ERp57

Top Publications

  1. Cicchillitti L, Di Michele M, Urbani A, Ferlini C, Donat M, Scambia G, et al. Comparative proteomic analysis of paclitaxel sensitive A2780 epithelial ovarian cancer cell line and its resistant counterpart A2780TC1 by 2D-DIGE: the role of ERp57. J Proteome Res. 2009;8:1902-12 pubmed
    ..proteins which were most strongly modulated by paclitaxel resistance and in particular on the disulphide isomerase ERp57, which may represent a chemoresistance biomarker...
  2. Hirano N, Shibasaki F, Sakai R, Tanaka T, Nishida J, Yazaki Y, et al. Molecular cloning of the human glucose-regulated protein ERp57/GRP58, a thiol-dependent reductase. Identification of its secretory form and inducible expression by the oncogenic transformation. Eur J Biochem. 1995;234:336-42 pubmed
    ..not code for an isotype of the phospholipase C superfamily but for one of the glucose-regulated proteins (GRPs), ERp57/GRP58. We have isolated human ERp57/GRP58 cDNA from human placenta...
  3. Wang Z, Zhou Z, Guo Z, Chi C. Snapshot of the interaction between HIV envelope glycoprotein 120 and protein disulfide isomerase. Acta Biochim Biophys Sin (Shanghai). 2010;42:358-62 pubmed
    ..The present results suggested the cell surface PDI might play a role in HIV entry in vivo. ..
  4. Kulp M, Frickel E, Ellgaard L, Weissman J. Domain architecture of protein-disulfide isomerase facilitates its dual role as an oxidase and an isomerase in Ero1p-mediated disulfide formation. J Biol Chem. 2006;281:876-84 pubmed
    ..These findings reveal how native disulfide folding is accomplished in the endoplasmic reticulum and provide a context for understanding the proliferation of PDI homologs with combinatorial arrangements of thioredoxin domains. ..
  5. Bi S, Hong P, Lee B, Baum L. Galectin-9 binding to cell surface protein disulfide isomerase regulates the redox environment to enhance T-cell migration and HIV entry. Proc Natl Acad Sci U S A. 2011;108:10650-5 pubmed publisher
    ..In addition, galectin-9 binding to PDI on T cells potentiates infection with HIV. We identify a mechanism for regulating cell surface redox status via a galectin-glycoprotein lattice, to regulate distinct T-cell functions. ..
  6. Reiser K, François K, Schols D, Bergman T, Jornvall H, Balzarini J, et al. Thioredoxin-1 and protein disulfide isomerase catalyze the reduction of similar disulfides in HIV gp120. Int J Biochem Cell Biol. 2012;44:556-62 pubmed publisher
    ..Our results demonstrate that both the host redox system and the viral surface glycoproteins are of interest for the development of new generations of anti-HIV therapeutics...
  7. Jessop C, Chakravarthi S, Garbi N, Hämmerling G, Lovell S, Bulleid N. ERp57 is essential for efficient folding of glycoproteins sharing common structural domains. EMBO J. 2007;26:28-40 pubmed
    b>ERp57 is a member of the protein disulphide isomerase family of oxidoreductases, which are involved in native disulphide bond formation in the endoplasmic reticulum of mammalian cells...
  8. Grillo C, D Ambrosio C, Scaloni A, Maceroni M, Merluzzi S, Turano C, et al. Cooperative activity of Ref-1/APE and ERp57 in reductive activation of transcription factors. Free Radic Biol Med. 2006;41:1113-23 pubmed
    b>ERp57, a protein disulfide isomerase localized mainly in the endoplasmic reticulum, has also been found in lesser amounts in the cytosol and nucleus, where its function is still not characterized...
  9. Peaper D, Wearsch P, Cresswell P. Tapasin and ERp57 form a stable disulfide-linked dimer within the MHC class I peptide-loading complex. EMBO J. 2005;24:3613-23 pubmed
    ..complex (MHC) class I chaperone tapasin can be detected as a mixed disulfide with the thiol-oxidoreductase ERp57. Here we show that tapasin is a unique and preferred substrate, a substantial majority of which is disulfide-..

More Information


  1. Ryser H, Fluckiger R. Progress in targeting HIV-1 entry. Drug Discov Today. 2005;10:1085-94 pubmed
    ..Inhibiting cell surface PDI prevents HIV-1 entry. The new potential targets outlined are PDI activity as well as the sites of PDI-CD4 and PDI-gp120 interaction. ..
  2. Appenzeller Herzog C, Riemer J, Zito E, Chin K, Ron D, Spiess M, et al. Disulphide production by Ero1?-PDI relay is rapid and effectively regulated. EMBO J. 2010;29:3318-29 pubmed publisher
    ..and mixed-disulphide complexes of Ero1 primarily form with PDI, to a lesser extent with the PDI-family members ERp57 and ERp72, but are not detectable with another homologue TMX3...
  3. Khanal R, Nemere I. The ERp57/GRp58/1,25D3-MARRS receptor: multiple functional roles in diverse cell systems. Curr Med Chem. 2007;14:1087-93 pubmed
    ERp57/GRp58 is a thiol-protein disulphide oxidoreductase and has been studied in many clinically relevant systems, both as a chaperone protein and as a membrane receptor for the steroid hormone, 1,25(OH)2D3...
  4. Pressinotti N, Klocker H, Schafer G, Luu V, Ruschhaupt M, Kuner R, et al. Differential expression of apoptotic genes PDIA3 and MAP3K5 distinguishes between low- and high-risk prostate cancer. Mol Cancer. 2009;8:130 pubmed publisher
    ..The genes MAP3K5 and PDIA3 are associated with malignant stages of prostate cancer and therefore provide novel potential biomarkers. ..
  5. Jessop C, Tavender T, Watkins R, Chambers J, Bulleid N. Substrate specificity of the oxidoreductase ERp57 is determined primarily by its interaction with calnexin and calreticulin. J Biol Chem. 2009;284:2194-202 pubmed publisher
    ..One such enzyme, ERp57, is thought to catalyze the isomerization of non-native disulfide bonds formed in glycoproteins with unstructured ..
  6. Aureli C, Gaucci E, Arcangeli V, Grillo C, Eufemi M, Chichiarelli S. ERp57/PDIA3 binds specific DNA fragments in a melanoma cell line. Gene. 2013;524:390-5 pubmed publisher
    b>ERp57/PDIA3 is a ubiquitously expressed disulfide isomerase protein, which acts in concert with calreticulin and calnexin in the folding of glycoproteins destined to the plasma membrane or to be secreted...
  7. Dong G, Wearsch P, Peaper D, Cresswell P, Reinisch K. Insights into MHC class I peptide loading from the structure of the tapasin-ERp57 thiol oxidoreductase heterodimer. Immunity. 2009;30:21-32 pubmed publisher
    ..multimeric peptide-loading complex (PLC) as a disulfide-linked, stable heterodimer with the thiol oxidoreductase ERp57, and this covalent interaction is required to support optimal PLC activity. Here, we present the 2...
  8. Oliver J, Roderick H, Llewellyn D, High S. ERp57 functions as a subunit of specific complexes formed with the ER lectins calreticulin and calnexin. Mol Biol Cell. 1999;10:2573-82 pubmed
    b>ERp57 is a lumenal protein of the endoplasmic reticulum (ER) and a member of the protein disulfide isomerase (PDI) family. In contrast to archetypal PDI, ERp57 interacts specifically with newly synthesized glycoproteins...
  9. Oliver J, van der Wal F, Bulleid N, High S. Interaction of the thiol-dependent reductase ERp57 with nascent glycoproteins. Science. 1997;275:86-8 pubmed
    ..A carbohydrate-dependent interaction between newly synthesized glycoproteins, the thiol-dependent reductase ERp57, and either calnexin or calreticulin was identified...
  10. Frickel E, Frei P, Bouvier M, Stafford W, Helenius A, Glockshuber R, et al. ERp57 is a multifunctional thiol-disulfide oxidoreductase. J Biol Chem. 2004;279:18277-87 pubmed
    The thiol-disulfide oxidoreductase ERp57 is a soluble protein of the endoplasmic reticulum and the closest known homologue of protein disulfide isomerase...
  11. Russell S, Ruddock L, Salo K, Oliver J, Roebuck Q, Llewellyn D, et al. The primary substrate binding site in the b' domain of ERp57 is adapted for endoplasmic reticulum lectin association. J Biol Chem. 2004;279:18861-9 pubmed
    b>ERp57 is a member of the protein disulfide isomerase (PDI) family that is located in the endoplasmic reticulum (ER) and characterized by its specificity for glycoproteins...
  12. Billington J, Hickling T, Munro G, Halai C, Chung R, Dodson G, et al. Stability of a receptor-binding active human immunodeficiency virus type 1 recombinant gp140 trimer conferred by intermonomer disulfide bonding of the V3 loop: differential effects of protein disulfide isomerase on CD4 and coreceptor binding. J Virol. 2007;81:4604-14 pubmed
    ..The relevance of these findings to the roles of the V3 domain and the timing of PDI action during the HIV infection process are discussed. ..
  13. Garbi N, Hämmerling G, Tanaka S. Interaction of ERp57 and tapasin in the generation of MHC class I-peptide complexes. Curr Opin Immunol. 2007;19:99-105 pubmed
    ..The identification of a covalent association between the thiol oxidoreductase ERp57 and tapasin, and its impact on the loading complex, are important recent developments in this field of research...
  14. Kang S, Cresswell P. Calnexin, calreticulin, and ERp57 cooperate in disulfide bond formation in human CD1d heavy chain. J Biol Chem. 2002;277:44838-44 pubmed
    ..Here we show that CD1d associates in the ER with both calnexin and calreticulin and with the thiol oxidoreductase ERp57 in a manner dependent on glucose trimming of its N-linked glycans...
  15. Chambers J, Jessop C, Bulleid N. Formation of a major histocompatibility complex class I tapasin disulfide indicates a change in spatial organization of the peptide-loading complex during assembly. J Biol Chem. 2008;283:1862-9 pubmed
    ..The formation of a mixed disulfide between the heavy chain of Class I and components of the loading complex (ERp57, protein disulfide isomerase, and tapasin) suggests that these molecules are involved in the redox regulation of ..
  16. Ramírez Rangel I, Bracho Valdés I, Vázquez Macías A, Carretero Ortega J, Reyes Cruz G, Vazquez Prado J. Regulation of mTORC1 complex assembly and signaling by GRp58/ERp57. Mol Cell Biol. 2011;31:1657-71 pubmed publisher
    ..Here, we demonstrate that GRp58/ERp57 regulates the existence and activity of mTORC1...
  17. Erickson R, Dunning L, Olson D, Cohen S, Davis A, Wood W, et al. In cerebrospinal fluid ER chaperones ERp57 and calreticulin bind beta-amyloid. Biochem Biophys Res Commun. 2005;332:50-7 pubmed
    ..of cerebrospinal fluid (CSF) from normals, we find that the bulk of the abetas are bound to the ER chaperones, ERp57 and calreticulin, suggesting that these may be carrier proteins which prevent aggregation of the abetas and that ..
  18. Holbrook L, Watkins N, Simmonds A, Jones C, Ouwehand W, Gibbins J. Platelets release novel thiol isomerase enzymes which are recruited to the cell surface following activation. Br J Haematol. 2010;148:627-37 pubmed publisher the presence of five additional thiol isomerases in human and mouse platelets and megakaryocytes, namely; ERp57, ERp72, ERp44, ERp29 and TMX3...
  19. Chichiarelli S, Gaucci E, Ferraro A, Grillo C, Altieri F, Cocchiola R, et al. Role of ERp57 in the signaling and transcriptional activity of STAT3 in a melanoma cell line. Arch Biochem Biophys. 2010;494:178-83 pubmed publisher
    Chromatin immunoprecipitation in M14 melanoma cells showed that the protein ERp57 (endoplasmic reticulum protein 57) binds to DNA in the proximity of STAT3 in a subset of STAT3-regulated genes...
  20. Stepensky D, Bangia N, Cresswell P. Aggregate formation by ERp57-deficient MHC class I peptide-loading complexes. Traffic. 2007;8:1530-42 pubmed
    The endoplasmic reticulum (ER)-resident proteins TAP, tapasin and ERp57 are the core components of the major histocompatibility complex (MHC) class I peptide-loading complex and play an important role in peptide loading by MHC class I-..
  21. Barbouche R, Miquelis R, Jones I, Fenouillet E. Protein-disulfide isomerase-mediated reduction of two disulfide bonds of HIV envelope glycoprotein 120 occurs post-CXCR4 binding and is required for fusion. J Biol Chem. 2003;278:3131-6 pubmed
    ..Disulfide bond restructuring within Env may constitute the molecular basis of the post-receptor binding conformational changes that induce fusion competence. ..
  22. Gallina A, Hanley T, Mandel R, Trahey M, Broder C, Viglianti G, et al. Inhibitors of protein-disulfide isomerase prevent cleavage of disulfide bonds in receptor-bound glycoprotein 120 and prevent HIV-1 entry. J Biol Chem. 2002;277:50579-88 pubmed
    ..Conformational changes resulting from the opening of gp120-disulfide loops may drive the processes of virus-cell and cell-cell fusion. The biochemical events described identify new potential targets for anti-HIV agents. ..
  23. Turano C, Gaucci E, Grillo C, Chichiarelli S. ERp57/GRP58: a protein with multiple functions. Cell Mol Biol Lett. 2011;16:539-63 pubmed publisher
    The protein ERp57/GRP58 is a stress-responsive protein and a component of the protein disulfide isomerase family...
  24. Leys C, Nomura S, Lafleur B, Ferrone S, Kaminishi M, Montgomery E, et al. Expression and prognostic significance of prothymosin-alpha and ERp57 in human gastric cancer. Surgery. 2007;141:41-50 pubmed
    Prothymosin-alpha and ERp57 were previously identified as markers for gastric metaplasia in a mouse model of Helicobacter-induced gastric metaplasia and neoplasia...
  25. Kozlov G, Maattanen P, Schrag J, Pollock S, Cygler M, Nagar B, et al. Crystal structure of the bb' domains of the protein disulfide isomerase ERp57. Structure. 2006;14:1331-9 pubmed
    ..Using small-angle X-ray scattering and X-ray crystallography, we report the structure of a selective isomerase, ERp57, and its interactions with the lectin chaperone calnexin...
  26. Antoniou A, Ford S, Alphey M, Osborne A, Elliott T, Powis S. The oxidoreductase ERp57 efficiently reduces partially folded in preference to fully folded MHC class I molecules. EMBO J. 2002;21:2655-63 pubmed
    The oxidoreductase ERp57 is an integral component of the peptide loading complex of major histocompatibility complex (MHC) class I molecules, formed during their chaperone-assisted assembly in the endoplasmic reticulum...
  27. Pendyala G, Ninemire C, Fox H. Protective role for the disulfide isomerase PDIA3 in methamphetamine neurotoxicity. PLoS ONE. 2012;7:e38909 pubmed publisher
    ..The current study implicates PDIA3 to be an important cellular neuroprotective mechanism against a toxic drug, and as a potential target for therapeutic investigations. ..
  28. Jeffries J, Jia J, Choi W, Choe S, Miao J, Xu Y, et al. Pseudomonas aeruginosa pyocyanin modulates mucin glycosylation with sialyl-Lewis(x) to increase binding to airway epithelial cells. Mucosal Immunol. 2016;9:1039-1050 pubmed publisher
    ..These results indicate that PA secretes PCN to induce a favorable environment for chronic colonization of CF lungs by increasing the glycosylation of airway mucins with sialyl-Lewis(x). ..
  29. Zhu Y, Cai L, Guo J, Chen N, Yi X, Zhao Y, et al. Depletion of Dicer promotes epithelial ovarian cancer progression by elevating PDIA3 expression. Tumour Biol. 2016;37:14009-14023 pubmed
    ..Moreover, the miRNAs targeting PDIA3 were decreased in cells with Dicer depletion. In summary, low Dicer expression contributes to epithelial ovarian cancer progression by elevating PDIA3 expression. ..
  30. Kung P, Hsieh P, Lin Y, Lee J, Chen I, Wu C. HPW-RX40 prevents human platelet activation by attenuating cell surface protein disulfide isomerases. Redox Biol. 2017;13:266-277 pubmed publisher
    ..HPW-RX40 inhibited the activity of recombinant PDI family proteins (PDI, ERp57, and ERp5) as well as suppressed cell surface PDI activity of platelets in a reversible manner...
  31. Salinas G. An isomerase completes the circuit for a redox switch. J Biol Chem. 2018;293:2650-2651 pubmed publisher study from Khosla and colleagues shows that TG2 is oxidatively inactivated by the protein disulfide isomerase ERp57, providing the first example of a defined and reversible protein-controlled redox switch and pointing to new ..
  32. Cresswell P, Bangia N, Dick T, Diedrich G. The nature of the MHC class I peptide loading complex. Immunol Rev. 1999;172:21-8 pubmed
    ..components two soluble 'house-keeping' proteins, the chaperone calreticulin and the thiol oxidoreductase ERp57, are also components of this complex...
  33. Guo G, Patel K, Kumar V, Shah M, Fried V, Etlinger J, et al. Association of the chaperone glucose-regulated protein 58 (GRP58/ER-60/ERp57) with Stat3 in cytosol and plasma membrane complexes. J Interferon Cytokine Res. 2002;22:555-63 pubmed
    Glucose-regulated protein 58 (GRP58/ER-60/ERp57), best known as a chaperone in the endoplasmic reticulum lumen, was previously identified by us as one of several accessory proteins in the S100 cytosol fraction of human hepatoma Hep3B ..
  34. Kullmann M, Kalayda G, Hellwig M, Kotz S, Hilger R, Metzger S, et al. Assessing the contribution of the two protein disulfide isomerases PDIA1 and PDIA3 to cisplatin resistance. J Inorg Biochem. 2015;153:247-252 pubmed publisher
    ..Our results warrant further evaluation of PDIA1 as promising target for chemotherapy, and its inhibition by PACMA31 as a new therapeutic approach. ..
  35. Da Costa G, Gomig T, Kaviski R, Santos Sousa K, Kukolj C, de Lima R, et al. Comparative Proteomics of Tumor and Paired Normal Breast Tissue Highlights Potential Biomarkers in Breast Cancer. Cancer Genomics Proteomics. 2015;12:251-61 pubmed
    ..Taking the fold change as a parameter, we point to future targets to be studied by functional methods in a search for biomarkers for initiation and progress of breast cancer. ..
  36. Sever L, Vo N, Bols N, Dixon B. Tapasin's protein interactions in the rainbow trout peptide-loading complex. Dev Comp Immunol. 2018;81:262-270 pubmed publisher
    ..the interaction of tapasin with the transporter associated with antigen processing (TAP), MHC class I and ERp57. Importantly, a 20 kDa tapasin version that contains an intact C and N terminal domains was found to associate ..
  37. Hsu S, Cheng J, Wang C, Ko J, Hsu C. Extracorporeal Shockwave Therapy Enhances Expression of Pdia-3 Which Is a Key Factor of the 1?,25-Dihydroxyvitamin D 3 Rapid Membrane Signaling Pathway in Treatment of Early Osteoarthritis of the Knee. Int J Med Sci. 2017;14:1220-1230 pubmed publisher
  38. Zhu X, Peng J, Chen D, Liu X, Ye L, Iijima H, et al. Calnexin and ERp57 facilitate the assembly of the neonatal Fc receptor for IgG with beta 2-microglobulin in the endoplasmic reticulum. J Immunol. 2005;175:967-76 pubmed
    ..However, calreticulin only bound to the FcRn H chain-beta(2)m complex. Furthermore, the thiol oxidoreductase ERp57 was detected in FcRn-CNX complexes, suggesting its role in disulfide bond formation of the FcRn H chain...
  39. Tang L, Luo J, Li Y, Ge R, Li Q. Hepatotoxicity and proteomic mechanism of Di-n-butyl-di-(4-chlorobenzohydroxamato)tin(IV) (DBDCT) in vivo. Environ Toxicol Pharmacol. 2017;51:38-44 pubmed publisher
  40. Ashrafi M, Sebastian A, Shih B, Greaves N, Alonso Rasgado T, Baguneid M, et al. Whole genome microarray data of chronic wound debridement prior to application of dermal skin substitutes. Wound Repair Regen. 2016;24:870-875 pubmed publisher
    ..These novel findings, albeit with limited clinical specimen numbers, strengthen the recommendation to transform chronic into acute wounds prior to application of DSS. ..
  41. Frickel E, Riek R, Jelesarov I, Helenius A, Wuthrich K, Ellgaard L. TROSY-NMR reveals interaction between ERp57 and the tip of the calreticulin P-domain. Proc Natl Acad Sci U S A. 2002;99:1954-9 pubmed
    ..It interacts with ERp57, a thiol-disulfide oxidoreductase that promotes the formation of disulfide bonds in glycoproteins bound by CRT...
  42. Li Q, Cui P, Miao Y, Gao F, Li X, Qian W, et al. Activation of group I metabotropic glutamate receptors regulates the excitability of rat retinal ganglion cells by suppressing Kir and I h. Brain Struct Funct. 2017;222:813-830 pubmed publisher
    ..Our results suggest that activation of mGluR I regulates the excitability of rat RGCs by inhibiting Kir and I h. ..
  43. Vuong B, Hogan Cann A, Alano C, Stevenson M, Chan W, Anderson C, et al. NF-κB transcriptional activation by TNFα requires phospholipase C, extracellular signal-regulated kinase 2 and poly(ADP-ribose) polymerase-1. J Neuroinflammation. 2015;12:229 pubmed publisher
    ..TNFα-induced PARP-1 activation is not associated with DNA damage, but ERK2 mediated phosphorylation of PARP-1. ..
  44. Basu A, Cajigas Du Ross C, Ríos Colón L, Mediavilla Varela M, Daniels Wells T, Leoh L, et al. LEDGF/p75 Overexpression Attenuates Oxidative Stress-Induced Necrosis and Upregulates the Oxidoreductase ERP57/PDIA3/GRP58 in Prostate Cancer. PLoS ONE. 2016;11:e0146549 pubmed publisher
    ..cells led to the upregulation of transcript and protein levels of the thiol-oxidoreductase ERp57 (also known as GRP58 and PDIA3), whereas its depletion led to ERp57 transcript downregulation...
  45. Woehlbier U, Colombo A, Saaranen M, Pérez V, Ojeda J, Bustos F, et al. ALS-linked protein disulfide isomerase variants cause motor dysfunction. EMBO J. 2016;35:845-65 pubmed publisher
    ..we functionally characterized fourALS-linked mutations recently identified in two majorPDIgenes,PDIA1 andPDIA3/ERp57. Phenotypic screening in zebrafish revealed that the expression of thesePDIvariants induce motor defects ..
  46. Zou Q, Yang Z, Yuan Y, Li J, Liang L, Zeng G, et al. Clinicopathological features and CCT2 and PDIA2 expression in gallbladder squamous/adenosquamous carcinoma and gallbladder adenocarcinoma. World J Surg Oncol. 2013;11:143 pubmed publisher
    ..Therefore, CCT2 and PDIA3 could be potentially important diagnostic and prognostic biomarkers for both SC/ASC and AC subtypes of GBC. ..
  47. Mourer T, Normant V, Labbé S. Heme Assimilation in Schizosaccharomyces pombe Requires Cell-surface-anchored Protein Shu1 and Vacuolar Transporter Abc3. J Biol Chem. 2017;292:4898-4912 pubmed publisher
  48. Xu D, Perez R, Rezaiekhaligh M, Bourdi M, Truog W. Knockdown of ERp57 increases BiP/GRP78 induction and protects against hyperoxia and tunicamycin-induced apoptosis. Am J Physiol Lung Cell Mol Physiol. 2009;297:L44-51 pubmed publisher
    ..b>ERp57 is an ER protein and is associated with calreticulin and calnexin in protein glycosylation...
  49. Yang W, Yu H, Kim J, Lee M, Park S. Vitamin D-induced ectodomain shedding of TNF receptor 1 as a nongenomic action: D3 vs D2 derivatives. J Steroid Biochem Mol Biol. 2016;155:18-25 pubmed publisher
    ..The plasma membrane receptor, endoplasmic reticulum stress protein 57 (ERp57), but not the classic vitamin D receptor, mediated the nongenomic action of vitamin D to induce ectodomain ..
  50. Wanamaker C, Green W. Endoplasmic reticulum chaperones stabilize nicotinic receptor subunits and regulate receptor assembly. J Biol Chem. 2007;282:31113-23 pubmed
    We examined interactions between the endoplasmic reticulum (ER) chaperones calnexin (CN), ERp57, and immunological heavy chain-binding protein (BiP) and nicotinic acetylcholine receptor (nAChR) subunits...
  51. Bennett C, Balcarek J, Varrichio A, Crooke S. Molecular cloning and complete amino-acid sequence of form-I phosphoinositide-specific phospholipase C. Nature. 1988;334:268-70 pubmed
    ..Although the sequence has little similarity with the only other sequenced PI-PLC isoenzyme, it has a surprising degree of similarity to thioredoxins, protein co-factors in thiol-dependent redox reactions. ..
  52. Charnock Jones D, Day K, Smith S. Cloning, expression and genomic organization of human placental protein disulfide isomerase (previously identified as phospholipase C alpha). Int J Biochem Cell Biol. 1996;28:81-9 pubmed
    ..The nucleotide sequence shows marked conservation of the coding and regulatory regions which may suggest that this enzyme has evolved to perform a highly specialized function. ..
  53. Androlewicz M. The role of tapasin in MHC class I antigen assembly. Immunol Res. 1999;20:79-88 pubmed
    ..may or may not include the interaction of class I molecules with the accessory proteins tapasin, calreticulin, ERp57, or TAP...
  54. Di Jeso B, Morishita Y, Treglia A, Lofrumento D, Nicolardi G, Beguinot F, et al. Transient covalent interactions of newly synthesized thyroglobulin with oxidoreductases of the endoplasmic reticulum. J Biol Chem. 2014;289:11488-96 pubmed publisher, only Tg "adduct B" was identified as primarily engaging the endoplasmic reticulum oxidoreductases ERp57 and protein disulfide isomerase...
  55. Ramos F, Serino L, Carvalho C, Lima R, Urban C, Cavalli I, et al. PDIA3 and PDIA6 gene expression as an aggressiveness marker in primary ductal breast cancer. Genet Mol Res. 2015;14:6960-7 pubmed publisher
    ..0351). Our results suggest that alterations in PDIA3/6 expression levels may be involved in the breast carcinogenic process and should be further investigated as a marker of aggressiveness. ..
  56. Wu W, Beilhartz G, Roy Y, Richard C, Curtin M, Brown L, et al. Nuclear translocation of the 1,25D3-MARRS (membrane associated rapid response to steroids) receptor protein and NFkappaB in differentiating NB4 leukemia cells. Exp Cell Res. 2010;316:1101-8 pubmed publisher
    ..This 57 kDa protein, named 1,25D(3)-MARRS (Membrane Activated Rapid Response to Steroids)/ERp57/PIA3 appears to associate in a complex with the transcription factor, nuclear factor kappa B (NFkappaB)...
  57. Alanen H, Williamson R, Howard M, Hatahet F, Salo K, Kauppila A, et al. ERp27, a new non-catalytic endoplasmic reticulum-located human protein disulfide isomerase family member, interacts with ERp57. J Biol Chem. 2006;281:33727-38 pubmed
    ..In addition, we report that ERp27 is bound by ERp57 both in vitro and in vivo by a similar mechanism by which ERp57 binds calreticulin.
  58. Oberčkal J, Kovačič L, Šribar J, Leonardi A, Dolinar K, Pucer Janež A, et al. On the role of protein disulfide isomerase in the retrograde cell transport of secreted phospholipases A2. PLoS ONE. 2015;10:e0120692 pubmed publisher
    ..The sPLA2-hPDI model constitutes a valuable tool to facilitate further insights into this process and into the (patho)physiology of sPLA2s in relation to their action intracellularly. ..
  59. Teodorof C, Divakar S, Soontornniyomkij B, Achim C, Kaul M, Singh K. Intracellular mannose binding lectin mediates subcellular trafficking of HIV-1 gp120 in neurons. Neurobiol Dis. 2014;69:54-64 pubmed publisher
    ..Thus, our findings suggest that intracellular MBL mediates subcellular trafficking and transport of viral glycoproteins in a microtubule-dependent mechanism in the neurons. ..
  60. Chung H, Cho H, Perry C, Song J, Ylaya K, Lee H, et al. Downregulation of ERp57 expression is associated with poor prognosis in early-stage cervical cancer. Biomarkers. 2013;18:573-9 pubmed publisher
    We investigated the clinical significance of ERp57 in the progression of cervical cancer. mRNA and protein expression of ERp57 in cervical neoplasias were examined. ERp57 mRNA expression was significantly decreased in cervical cancers...
  61. Amantini C, Farfariello V, Cardinali C, Morelli M, Marinelli O, Nabissi M, et al. The TRPV1 ion channel regulates thymocyte differentiation by modulating autophagy and proteasome activity. Oncotarget. 2017;8:90766-90780 pubmed publisher
    ..The TRPV1-mediated autophagy prevents the UPR activation by inhibiting BiP, Grp94 and ERp57 chaperone protein expression...
  62. Bourdi M, Demady D, Martin J, Jabbour S, Martin B, George J, et al. cDNA cloning and baculovirus expression of the human liver endoplasmic reticulum P58: characterization as a protein disulfide isomerase isoform, but not as a protease or a carnitine acyltransferase. Arch Biochem Biophys. 1995;323:397-403 pubmed
    The function of a 58-kDa liver microsomal protein (P58) is controversial...
  63. Giamogante F, Marrocco I, Romaniello D, Eufemi M, Chichiarelli S, Altieri F. Comparative Analysis of the Interaction between Different Flavonoids and PDIA3. Oxid Med Cell Longev. 2016;2016:4518281 pubmed publisher
    ..The binding site is probably similar but not equivalent to that of green tea catechins, which, as previously demonstrated, can bind to PDIA3 and prevent its interaction with DNA. ..
  64. Zhang X, Pan Y, Yu C, Xu C, Xu L, Li Y, et al. PDIA3 Knockdown Exacerbates Free Fatty Acid-Induced Hepatocyte Steatosis and Apoptosis. PLoS ONE. 2015;10:e0133882 pubmed publisher
    ..This study aims to analyze the potential role of protein disulfide isomerase A3 precursor (PDIA3), one of the ER chaperones, in free fatty acid-induced cell model of NAFLD...
  65. Chay D, Cho H, Lim B, Kang E, Oh Y, Choi S, et al. ER-60 (PDIA3) is highly expressed in a newly established serous ovarian cancer cell line, YDOV-139. Int J Oncol. 2010;37:399-412 pubmed
    ..001). The molecular characteristics of YDOV-139 may have implications for future ovarian cancer research and ER-60 (PDIA3) should be investigated further as a potential biomarker of ovarian cancer. ..
  66. Barbouche R, Lortat Jacob H, Jones I, Fenouillet E. Glycosaminoglycans and protein disulfide isomerase-mediated reduction of HIV Env. Mol Pharmacol. 2005;67:1111-8 pubmed
  67. Yuan G, Hua B, Yang Y, Xu L, Cai T, Sun N, et al. The Circadian Gene Clock Regulates Bone Formation Via PDIA3. J Bone Miner Res. 2017;32:861-871 pubmed publisher
    ..Our results demonstrate that the core circadian gene Clock regulates bone formation via transcriptional control of 1,2,5(OH)2D3 receptor PDIA3. © 2016 American Society for Bone and Mineral Research. ..
  68. Okudo H, Kito M, Moriyama T, Ogawa T, Urade R. Transglutaminase activity of human ER-60. Biosci Biotechnol Biochem. 2002;66:1423-6 pubmed
    ..These results suggest that the properties of the transglutaminase activity of ER-60 are different from those in the cases of known mammalian transglutaminases of which the active site includes a cysteine residue. ..
  69. Lwin Z, Yip G, Chew F, Bay B. Downregulation of ER60 protease inhibits cellular proliferation by inducing G1/S arrest in breast cancer cells in vitro. Anat Rec (Hoboken). 2012;295:410-6 pubmed publisher
    b>ER60 protease, a 58-kDa molecular chaperone in the endoplasmic reticulum, is involved in glycoprotein synthesis. ER60 protease has been reported to be differentially expressed in various cancers including breast carcinoma...
  70. Sequeira V, Rybchyn M, Tongkao On W, Gordon Thomson C, Malloy P, Nemere I, et al. The role of the vitamin D receptor and ERp57 in photoprotection by 1?,25-dihydroxyvitamin D3. Mol Endocrinol. 2012;26:574-82 pubmed publisher
    ..tested the involvement of the classical vitamin D receptor (VDR) and the endoplasmic reticulum stress protein 57 (ERp57), in the mechanisms of photoprotection...
  71. Hulpke S, Baldauf C, Tampe R. Molecular architecture of the MHC I peptide-loading complex: one tapasin molecule is essential and sufficient for antigen processing. FASEB J. 2012;26:5071-80 pubmed publisher
    ..In summary, the human PLC consists maximally of 2× tapasin-ERp57/MHC I per TAP complex, but one tapasin-ERp57/MHC I in the PLC is essential and sufficient for antigen processing.
  72. Gan C, Yusof R, Othman S. Different serotypes of dengue viruses differently regulate the expression of the host cell antigen processing machinery. Acta Trop. 2015;149:8-14 pubmed publisher
    ..The profiles of the gene expression were further validated. We showed that all four DV serotypes modulate host APM at the proteasomal level with DV2 showing the most prominent expression profile. ..
  73. Castillo V, Oñate M, Woehlbier U, Rozas P, Andreu C, Medinas D, et al. Functional Role of the Disulfide Isomerase ERp57 in Axonal Regeneration. PLoS ONE. 2015;10:e0136620 pubmed publisher
    b>ERp57 (also known as grp58 and PDIA3) is a protein disulfide isomerase that catalyzes disulfide bonds formation of glycoproteins as part of the calnexin and calreticulin cycle...
  74. Rudolph M, Stevens J, Speir J, Trowsdale J, Butcher G, Joly E, et al. Crystal structures of two rat MHC class Ia (RT1-A) molecules that are associated differentially with peptide transporter alleles TAP-A and TAP-B. J Mol Biol. 2002;324:975-90 pubmed
    ..ER) by a complex consisting of the MHC class I heavy chain, beta(2)-microglobulin, calreticulin, tapasin, Erp57 (ER60) and the transporter associated with antigen processing (TAP)...
  75. Grindel B, Rohe B, Safford S, Bennett J, Farach Carson M. Tumor necrosis factor-α treatment of HepG2 cells mobilizes a cytoplasmic pool of ERp57/1,25D₃-MARRS to the nucleus. J Cell Biochem. 2011;112:2606-15 pubmed publisher
    b>ERp57/PDIA3/1,25-MARRS has diverse functions and multiple cellular locations in various cell types...
  76. Hettinghouse A, Liu R, Liu C. Multifunctional molecule ERp57: From cancer to neurodegenerative diseases. Pharmacol Ther. 2018;181:34-48 pubmed publisher
    ..b>ERp57, a prominent multifunctional member of the PDI family, is detected at various levels in multiple cellular ..
  77. Xiao B, Wang J, Han F, Shi Y. Effects of calcium-dependent molecular chaperones and endoplasmic reticulum in the amygdala in rats under single?prolonged stress. Mol Med Rep. 2017;: pubmed publisher
    ..The present study detected changes of calreticulin (CRT), calnexin (CNX) and ERp57 in the amygdala of rats, which may with aim of providing a novel insight into the modulation effect of amygdala in ..