Gene Symbol: ERP29
Description: endoplasmic reticulum protein 29
Alias: C12orf8, ERp28, ERp31, HEL-S-107, PDI-DB, PDIA9, endoplasmic reticulum resident protein 29, endoplasmic reticulum lumenal protein ERp28, endoplasmic reticulum resident protein 28, endoplasmic reticulum resident protein 31, epididymis secretory protein Li 107, protein disulfide isomerase family A, member 9
Species: human
Products:     ERP29

Top Publications

  1. Zheng J, Liu X, Yan X, Dai L, Ji C. Purification and structural characterization of human ERp29. Protein Pept Lett. 2006;13:753-9 pubmed
    b>ERp29 is a major resident of the endoplasmic reticulum (ER) and is postulated to play an important molecular chaperone role in most animal cells...
  2. Mkrtchian S, Baryshev M, Sargsyan E, Chatzistamou I, Volakaki A, Chaviaras N, et al. ERp29, an endoplasmic reticulum secretion factor is involved in the growth of breast tumor xenografts. Mol Carcinog. 2008;47:886-92 pubmed publisher
    ..We have addressed the role of ERp29, a novel endoplasmic reticulum secretion factor in mammary carcinogenesis using MCF-7 human breast cancer cells as ..
  3. Mkrtchian S, Fang C, Hellman U, Ingelman Sundberg M. A stress-inducible rat liver endoplasmic reticulum protein, ERp29. Eur J Biochem. 1998;251:304-13 pubmed
    We have isolated, cDNA cloned and characterised a 29-kDa protein (ERp29), containing a C-terminal endoplasmic reticulum(ER)-retrieval signal, from the rat liver ER...
  4. Bambang I, Xu S, Zhou J, Salto Tellez M, Sethi S, Zhang D. Overexpression of endoplasmic reticulum protein 29 regulates mesenchymal-epithelial transition and suppresses xenograft tumor growth of invasive breast cancer cells. Lab Invest. 2009;89:1229-42 pubmed publisher
    Endoplasmic reticulum protein 29 (ERp29) is a novel endoplasmic reticulum (ER) secretion factor that facilitates the transport of secretory proteins in the early secretory pathway...
  5. Sargsyan E, Baryshev M, Backlund M, Sharipo A, Mkrtchian S. Genomic organization and promoter characterization of the gene encoding a putative endoplasmic reticulum chaperone, ERp29. Gene. 2002;285:127-39 pubmed
    b>ERp29 is a soluble protein localized in the endoplasmic reticulum (ER) of eukaryotic cells, which is conserved in all mammalian species...
  6. Hubbard M. Functional proteomics: The goalposts are moving. Proteomics. 2002;2:1069-78 pubmed
    ..As reviewed here for ERp29, a recently discovered endoplasmic reticulum protein, the role of novel proteins can remain elusive even after ..
  7. Cheretis C, Dietrich F, Chatzistamou I, Politi K, Angelidou E, Kiaris H, et al. Expression of ERp29, an endoplasmic reticulum secretion factor in basal-cell carcinoma. Am J Dermatopathol. 2006;28:410-2 pubmed
    The role of endoplasmic reticulum (ER)-stress proteins in the pathogenesis of neoplasia remains obscure. ERp29 encodes for an ER protein that is thought to facilitate the transport of secretory proteins in the early secretory pathway...
  8. Ferrari D, Nguyen Van P, Kratzin H, Söling H. ERp28, a human endoplasmic-reticulum-lumenal protein, is a member of the protein disulfide isomerase family but lacks a CXXC thioredoxin-box motif. Eur J Biochem. 1998;255:570-9 pubmed
    We report on the isolation, sequence and a putative role of a human endoplasmic-reticulum-lumenal protein, ERp28. The protein has the C-terminal retention signal KEEL and localizes to the endoplasmic reticulum (ER) as seen by subcellular ..
  9. Zhang D, Richardson D. Endoplasmic reticulum protein 29 (ERp29): An emerging role in cancer. Int J Biochem Cell Biol. 2011;43:33-6 pubmed publisher
    The endoplasmic reticulum protein 29 (ERp29) is a molecule that facilitates processing and transport of proteins in the early secretory pathway...

More Information


  1. Yu M, Yan W, Beight C. Lutein and Zeaxanthin Isomers Reduce Photoreceptor Degeneration in the Pde6b rd10 Mouse Model of Retinitis Pigmentosa. Biomed Res Int. 2018;2018:4374087 pubmed publisher
    ..78 kDa glucose-regulated protein (GRP78) and endoplasmic reticulum protein 29 (ERp29) were tested by western blot and immunostaining...
  2. Filis P, Nagrath N, Fraser M, Hay D, Iredale J, O Shaughnessy P, et al. Maternal Smoking Dysregulates Protein Expression in Second Trimester Human Fetal Livers in a Sex-Specific Manner. J Clin Endocrinol Metab. 2015;100:E861-70 pubmed publisher
    ..Maternal smoking affected proteins with roles in post-translational protein processing and secretion (ERP29, PDIA3), stress responses and detoxification (HSP90AA1, HSBP1, ALDH7A1, CAT), and homeostasis (FTL1, ECHS1, GLUD1, ..
  3. Dowling P, O Driscoll L, O SULLIVAN F, Dowd A, Henry M, Jeppesen P, et al. Proteomic screening of glucose-responsive and glucose non-responsive MIN-6 beta cells reveals differential expression of proteins involved in protein folding, secretion and oxidative stress. Proteomics. 2006;6:6578-87 pubmed
    ..These proteins included endoplasmic reticulum protein 29 (ERp29); 78-kDa glucose-related protein, (GRP78); 94-kDa glucose-related protein (GRP94); protein disulphide isomerase; ..
  4. Chen S, Zhao Y, Zhang Y, Zhang D. Fucoidan induces cancer cell apoptosis by modulating the endoplasmic reticulum stress cascades. PLoS ONE. 2014;9:e108157 pubmed publisher
    ..glucose regulated protein 78 (GRP78) in the metastatic MDA-MB-231 breast cancer cells, and of the ER protein 29 (ERp29) in the metastatic HCT116 colon cancer cells...
  5. McLaughlin T, Falkowski M, Wang J, Zhang S. Molecular Chaperone ERp29: A Potential Target for Cellular Protection in Retinal and Neurodegenerative Diseases. Adv Exp Med Biol. 2018;1074:421-427 pubmed publisher
    The molecular chaperone endoplasmic reticulum protein 29 (ERp29) plays a critical role in protein folding, trafficking, and secretion...
  6. Zhang Y, Belegu V, Zou Y, Wang F, Qian B, Liu R, et al. Endoplasmic Reticulum Protein 29 Protects Axotomized Neurons from Apoptosis and Promotes Neuronal Regeneration Associated with Erk Signal. Mol Neurobiol. 2015;52:522-32 pubmed publisher, Western blot (WB), and immunohistochemistry (IHC), we found endoplasmic reticulum protein 29 (ERp29) was substantially downregulated in the motor cortex 3 days postoperation (dpo) after spinal cord transection (SCT,..
  7. Ma J, Shen S, Wang J, He Z, Poon A, Li J, et al. Comparative Proteomic Analysis of the Mitochondria-associated ER Membrane (MAM) in a Long-term Type 2 Diabetic Rodent Model. Sci Rep. 2017;7:2062 pubmed publisher
    ..Using immunofluorescence labeling we confirmed the activation of three UPR branches and increased ERp29 and calreticulin in diabetic retinas...
  8. Gao J, Zhang Y, Wang L, Xia L, Lu M, Zhang B, et al. Endoplasmic reticulum protein 29 is involved in endoplasmic reticulum stress in islet beta cells. Mol Med Rep. 2016;13:398-402 pubmed publisher
    ..In the present study, the sub‑cellular localization and role of ER protein 29 (Erp29) were investigated in an in vitro ERS model of islet beta cells...
  9. Lu J, Lu D, Chen Y, Dong Y, Zhang J, Li T, et al. Proteomic analysis of hepatocellular carcinoma HepG2 cells treated with platycodin D. Chin J Nat Med. 2015;13:673-9 pubmed publisher
    ..proteins were identified to be up-regulated in PD-treated HepG2 cells, including ATP5H, OXCT1, KRT9, CCDC40, ERP29, RCN1, ZNF175, HNRNPH1, HSP27, PA2G4, PHB, BANF1, TPM3, ECH1, LGALS1, and MYL6. Three proteins (i.e...
  10. Shimizu S, Brown M, Sengupta R, Penfold M, Meucci O. CXCR7 protein expression in human adult brain and differentiated neurons. PLoS ONE. 2011;6:e20680 pubmed publisher
    ..Neuronal CXCR7 co-localizes to some extent with the endoplasmic reticulum marker ERp29, but not with early/late endosome markers...
  11. DiChiara A, Taylor R, Wong M, Doan N, Rosario A, Shoulders M. Mapping and Exploring the Collagen-I Proteostasis Network. ACS Chem Biol. 2016;11:1408-21 pubmed publisher
    ..Furthermore, quantitative analyses reveal that Erp29, an abundant endoplasmic reticulum proteostasis machinery component with few known functions, plays a key role in ..
  12. Rainey Barger E, Magnuson B, Tsai B. A chaperone-activated nonenveloped virus perforates the physiologically relevant endoplasmic reticulum membrane. J Virol. 2007;81:12996-3004 pubmed
    ..We showed previously that the ER chaperone ERp29 alters the conformation of Py coat protein VP1, enabling the virus to interact with membranes...
  13. Zhang Y, Hu Y, Wang J, Yao H, Wang H, Liang L, et al. Proteomic identification of ERP29 as a key chemoresistant factor activated by the aggregating p53 mutant Arg282Trp. Oncogene. 2017;36:5473-5483 pubmed publisher
    ..activation of unfolded protein response (UPR) pathway and upregulation of endoplasmic reticulum protein 29 (ERp29) in R282WTP53-expressing cells that were exposed to cisplatin stress...
  14. Grumbach Y, Bikard Y, Suaud L, Chanoux R, Rubenstein R. ERp29 regulates epithelial sodium channel functional expression by promoting channel cleavage. Am J Physiol Cell Physiol. 2014;307:C701-9 pubmed publisher
    ..b>ERp29 is a 29-kDa thioredoxin-homologous endoplasmic reticulum (ER) protein that has only a single cysteine instead of ..
  15. Wong P, Cheong W, Shu M, Teh C, Chan K, AbuBakar S. Eurycomanone suppresses expression of lung cancer cell tumor markers, prohibitin, annexin 1 and endoplasmic reticulum protein 28. Phytomedicine. 2012;19:138-44 pubmed publisher
    ..other cancer-associated genes including prohibitin (PHB), annexin 1 (ANX1) and endoplasmic reticulum protein 28 (ERp28) but not the house keeping genes...
  16. Jansen G, Maattanen P, Denisov A, Scarffe L, Schade B, Balghi H, et al. An interaction map of endoplasmic reticulum chaperones and foldases. Mol Cell Proteomics. 2012;11:710-23 pubmed publisher
  17. Zhang T, Guo Y, Guo X, Zhou T, Chen D, Xiang J, et al. Comparative proteomics analysis of placenta from pregnant women with intrahepatic cholestasis of pregnancy. PLoS ONE. 2013;8:e83281 pubmed publisher
    ..Three apoptosis related proteins ERp29, PRDX6 and MPO that resulted from iTRAQ-based proteomics were further verified in placenta by Western blotting and ..
  18. Zhang T, Zhao C, Luo L, Xiang J, Cheng J, Wang T, et al. High concentraction of taurocholic acid induced apoptosis in HTR-8/SVneo cells via overexpression of ERp29 and activation of p38. Placenta. 2014;35:496-500 pubmed publisher
    ..Our previous study using an iTRAQ-based proteomics approach showed that ERp29 was overexpressed in the placenta tissue of ICP patients, which was an apoptosis-related protein and has not been ..
  19. Suaud L, Miller K, Alvey L, Yan W, Robay A, Kebler C, et al. ERp29 regulates DeltaF508 and wild-type cystic fibrosis transmembrane conductance regulator (CFTR) trafficking to the plasma membrane in cystic fibrosis (CF) and non-CF epithelial cells. J Biol Chem. 2011;286:21239-53 pubmed publisher
    ..One transcript up-regulated by 4PBA encoded ERp29, a luminal resident of the endoplasmic reticulum (ER) thought to be a novel molecular chaperone...
  20. Holbrook L, Watkins N, Simmonds A, Jones C, Ouwehand W, Gibbins J. Platelets release novel thiol isomerase enzymes which are recruited to the cell surface following activation. Br J Haematol. 2010;148:627-37 pubmed publisher
    ..of five additional thiol isomerases in human and mouse platelets and megakaryocytes, namely; ERp57, ERp72, ERp44, ERp29 and TMX3...
  21. Shnyder S, Hubbard M. ERp29 is a ubiquitous resident of the endoplasmic reticulum with a distinct role in secretory protein production. J Histochem Cytochem. 2002;50:557-66 pubmed
    b>ERp29 was recently characterized biochemically as a novel protein that resides in mammalian endoplasmic reticulum (ER)...
  22. Bambang I, Lu D, Li H, Chiu L, Lau Q, Koay E, et al. Cytokeratin 19 regulates endoplasmic reticulum stress and inhibits ERp29 expression via p38 MAPK/XBP-1 signaling in breast cancer cells. Exp Cell Res. 2009;315:1964-74 pubmed publisher
    ..The level of ER protein 29 (ERp29) was shown to be decreased in the CK19-expressing BT549 cells by proteomic analyses and verified by Western ..
  23. Lippert U, Diao D, Barak N, Ferrari D. Conserved structural and functional properties of D-domain containing redox-active and -inactive protein disulfide isomerase-related protein chaperones. J Biol Chem. 2007;282:11213-20 pubmed
    ..Although a mammalian ortholog of Wind (ERp29/28) is known, conflicting interpretations of its structure and putative function have been postulated...
  24. Gao D, Bambang I, Putti T, Lee Y, Richardson D, Zhang D. ERp29 induces breast cancer cell growth arrest and survival through modulation of activation of p38 and upregulation of ER stress protein p58IPK. Lab Invest. 2012;92:200-13 pubmed publisher
    Endoplasmic reticulum protein 29 (ERp29) is an ER luminal protein that has a role in protein unfolding and secretion, but its role in cancer is unclear...
  25. Huang C, Wang J, Jing G, Li J, Jin C, Yu Q, et al. Erp29 Attenuates Cigarette Smoke Extract-Induced Endoplasmic Reticulum Stress and Mitigates Tight Junction Damage in Retinal Pigment Epithelial Cells. Invest Ophthalmol Vis Sci. 2015;56:6196-207 pubmed publisher
    Endoplasmic reticulum protein 29 (ERp29) is a novel chaperone that was recently found decreased in human retinas with AMD. Herein, we examined the effect of ERp29 on cigarette smoke-induced RPE apoptosis and tight junction disruption...
  26. Ye J, Huang J, Xu J, Huang Q, Wang J, Zhong W, et al. ERp29 controls invasion and metastasis of gastric carcinoma by inhibition of epithelial-mesenchymal transition via PI3K/Aktsignaling pathway. BMC Cancer. 2017;17:626 pubmed publisher
    ..Recently, the endoplasmic reticulum (ER) protein 29 (ERp29) has been shown to inversely associate with primary tumor development and function as a tumor suppressor in breast ..
  27. Hubbard M, McHugh N. Human ERp29: isolation, primary structural characterisation and two-dimensional gel mapping. Electrophoresis. 2000;21:3785-96 pubmed
    ..the isoelectric heterogeneity and anomalous mass on two-dimensional gels enabled two reported homologues (UL35 and ERp31) to be identified as ERp29...
  28. Kozlov G, Muñoz Escobar J, Castro K, Gehring K. Mapping the ER Interactome: The P Domains of Calnexin and Calreticulin as Plurivalent Adapters for Foldases and Chaperones. Structure. 2017;25:1415-1422.e3 pubmed publisher
    ..Recently, CRT was shown to interact with the chaperone ERp29. Here, we show that ERp29 directly binds to the P domain of CNX...
  29. Hughes G, Frutiger S, Paquet N, Pasquali C, Sanchez J, Tissot J, et al. Human liver protein map: update 1993. Electrophoresis. 1993;14:1216-22 pubmed
    ..SWISS-2DPAGE and the SWISS-PROT protein sequence databases are closely linked together through the use of common accession numbers. ..
  30. Wu P, Zhang H, Qi L, Tang Q, Tang Y, Xie Z, et al. Identification of ERp29 as a biomarker for predicting nasopharyngeal carcinoma response to radiotherapy. Oncol Rep. 2012;27:987-94 pubmed publisher
    ..Among these proteins, ERp29, Mn-SOD, HSP27 and GST ω1 were found to be significantly up-regulated in RR NPC tissues, and ..
  31. Chen S, Zhang Y, Zhang D. Endoplasmic reticulum protein 29 (ERp29) confers radioresistance through the DNA repair gene, O(6)-methylguanine DNA-methyltransferase, in breast cancer cells. Sci Rep. 2015;5:14723 pubmed publisher
    ..Our previous studies have demonstrated a significant role of ERp29 in breast cancer cell survival against doxorubicin-induced genotoxic stress...
  32. Galligan J, Petersen D. The human protein disulfide isomerase gene family. Hum Genomics. 2012;6:6 pubmed publisher
    ..Understanding the mechanisms of protein-folding, specifically thiol-disulfide exchange, may lead to development of a novel class of therapeutics that would help alleviate a wide range of diseases by targeting the UPR. ..
  33. Qi L, Wu P, Zhang X, Qiu Y, Jiang W, Huang D, et al. Inhibiting ERp29 expression enhances radiosensitivity in human nasopharyngeal carcinoma cell lines. Med Oncol. 2012;29:721-8 pubmed publisher
    b>ERp29 is an endoplasmic reticulum (ER) stress-inducible protein...
  34. Das S, Smith T, Sarma J, Ritzenthaler J, Maza J, Kaplan B, et al. ERp29 restricts Connexin43 oligomerization in the endoplasmic reticulum. Mol Biol Cell. 2009;20:2593-604 pubmed publisher
    ..Here, we provide evidence that an ER-localized, 29-kDa thioredoxin-family protein (ERp29) regulates Cx43 trafficking and function...
  35. Mkrtchian S, Sandalova T. ERp29, an unusual redox-inactive member of the thioredoxin family. Antioxid Redox Signal. 2006;8:325-37 pubmed focuses on the interesting example of a loss-of-function PDI-like protein from the endoplasmic reticulum, ERp29. ERp29 shares a common predecessor with PDI; however in the course of divergent evolution it has lost a hallmark ..
  36. Deng Y, Tang N, Liu C, Zhang J, An S, Peng Y, et al. CLIC4, ERp29, and Smac/DIABLO derived from metastatic cancer stem-like cells stratify prognostic risks of colorectal cancer. Clin Cancer Res. 2014;20:3809-17 pubmed publisher
    ..We identified three proteins, CLIC4, ERp29, and Smac/DIABLO, from metastatic cancer stem-like cells of colorectal cancer and verified the proteins' role in ..
  37. Yuan L, Liu D, Yang Z. Correlation of S1P1 and ERp29 expression to progression, metastasis, and poor prognosis of gallbladder adenocarcinoma. Hepatobiliary Pancreat Dis Int. 2013;12:189-95 pubmed
    ..evaluate the diagnostic and prognostic value of sphingosine-1-phosphate receptor 1 (S1P1) and endoplasmic reticulum protein 29 (ERp29) in benign and malignant gallbladder lesions and to develop a possible alternative treatment for GBC.
  38. Bambang I, Lee Y, Richardson D, Zhang D. Endoplasmic reticulum protein 29 regulates epithelial cell integrity during the mesenchymal-epithelial transition in breast cancer cells. Oncogene. 2013;32:1240-51 pubmed publisher
    ..We previously demonstrated that the endoplasmic reticulum protein 29 (ERp29) is a novel factor that can drive mesenchymal-epithelial transition (MET) and induce cell growth arrest in MDA-MB-..
  39. Zhang K, Yao H, Yang Z, Li D, Yang L, Zou Q, et al. Comparison of ILK and ERP29 expressions in benign and malignant pancreatic lesions and their clinicopathological significances in pancreatic ductal adenocarcinomas. Clin Transl Oncol. 2016;18:352-9 pubmed publisher
    ..ILK and ERP29 protein expressions in PDAC, peritumoral tissues, benign pancreatic lesions, and normal pancreatic tissues were ..
  40. Nakao H, Seko A, Ito Y, Sakono M. PDI family protein ERp29 recognizes P-domain of molecular chaperone calnexin. Biochem Biophys Res Commun. 2017;487:763-767 pubmed publisher
    ..In this study, we examined the ability of PDIs to interact with CNX. Among them ERp29 was shown to interact with CNX, similarly to ERp57...
  41. Farmaki E, Mkrtchian S, Papazian I, Papavassiliou A, Kiaris H. ERp29 regulates response to doxorubicin by a PERK-mediated mechanism. Biochim Biophys Acta. 2011;1813:1165-71 pubmed publisher
    b>ERp29 is an endoplasmic reticulum (ER) luminal protein with a putative secretion factor/escort chaperone function...
  42. Wu J, Yang Y, Gao S, Jiang H, Wang X, Xiao Y, et al. ERp29 inhibits tumorigenicity by suppressing epithelial mesenchymal transition in gastric cancer. Oncotarget. 2017;8:78757-78766 pubmed publisher
    b>ERp29 is a novel endoplasmic reticulum (ER) protein that plays an important role in protein unfolding and secretion. Recently, it has been reported to be widely implicated in control of tumorigenesis in some tumors...
  43. Barak N, Neumann P, Sevvana M, Schutkowski M, Naumann K, Malesevic M, et al. Crystal structure and functional analysis of the protein disulfide isomerase-related protein ERp29. J Mol Biol. 2009;385:1630-42 pubmed publisher
    The protein disulfide isomerase-related protein ERp29 is a putative chaperone involved in processing and secretion of secretory proteins...