ERG

Summary

Gene Symbol: ERG
Description: ERG, ETS transcription factor
Alias: erg-3, p55, transcriptional regulator ERG, FUS/ERG fusion protein, TMPRSS2/ERG fusion, erythroblast transformation-specific transcription factor ERG variant 10, ets-related, transcriptional regulator ERG (transforming protein ERG), v-ets avian erythroblastosis virus E26 oncogene homolog, v-ets avian erythroblastosis virus E26 oncogene related, v-ets erythroblastosis virus E26 oncogene homolog, v-ets erythroblastosis virus E26 oncogene like
Species: human
Products:     ERG

Top Publications

  1. Yuan L, Nikolova Krstevski V, Zhan Y, Kondo M, Bhasin M, Varghese L, et al. Antiinflammatory effects of the ETS factor ERG in endothelial cells are mediated through transcriptional repression of the interleukin-8 gene. Circ Res. 2009;104:1049-57 pubmed publisher
    b>ERG (Ets-related gene) is an ETS transcription factor that has recently been shown to regulate a number of endothelial cell (EC)-restricted genes including VE-cadherin, von Willebrand factor, endoglin, and intercellular adhesion molecule-..
  2. Park K, Dalton J, Narayanan R, Barbieri C, Hancock M, Bostwick D, et al. TMPRSS2:ERG gene fusion predicts subsequent detection of prostate cancer in patients with high-grade prostatic intraepithelial neoplasia. J Clin Oncol. 2014;32:206-11 pubmed publisher
    ..The predictive value of ERG gene fusion in HGPIN for PCa was interrogated as a post hoc analysis in the context of a randomized clinical trial.
  3. Minner S, Enodien M, Sirma H, Luebke A, Krohn A, Mayer P, et al. ERG status is unrelated to PSA recurrence in radically operated prostate cancer in the absence of antihormonal therapy. Clin Cancer Res. 2011;17:5878-88 pubmed publisher
    About 50% of prostate cancers have TMPRSS2-ERG fusions with concurrent ERG overexpression...
  4. Gupta S, Iljin K, Sara H, Mpindi J, Mirtti T, Vainio P, et al. FZD4 as a mediator of ERG oncogene-induced WNT signaling and epithelial-to-mesenchymal transition in human prostate cancer cells. Cancer Res. 2010;70:6735-45 pubmed publisher
    TMPRSS2-ERG and other gene fusions involving ETS factors and genes with strong promoter elements are common in prostate cancer...
  5. Jhavar S, Brewer D, Edwards S, Kote Jarai Z, Attard G, Clark J, et al. Integration of ERG gene mapping and gene-expression profiling identifies distinct categories of human prostate cancer. BJU Int. 2009;103:1256-69 pubmed publisher
    To integrate the mapping of ERG alterations with the collection of expression microarray (EMA) data, as previous EMA analyses have failed to consider the genetic heterogeneity and complex patterns of ERG alteration frequently found in ..
  6. Wu L, Zhao J, Kim J, Jin H, Wang C, Yu J. ERG is a critical regulator of Wnt/LEF1 signaling in prostate cancer. Cancer Res. 2013;73:6068-79 pubmed publisher
    ..translocations juxtaposing the androgen-responsive TMPRSS2 promoter with the ETS-family transcription factor ERG result in aberrant ERG upregulation in approximately 50% of prostate cancers...
  7. Wang J, Cai Y, Yu W, Ren C, Spencer D, Ittmann M. Pleiotropic biological activities of alternatively spliced TMPRSS2/ERG fusion gene transcripts. Cancer Res. 2008;68:8516-24 pubmed publisher
    TMPRSS2/ERG gene fusions are found in the majority of prostate cancers; however, there is significant heterogeneity in the 5' region of the alternatively spliced fusion gene transcripts...
  8. Baldus C, Burmeister T, Martus P, Schwartz S, Gökbuget N, Bloomfield C, et al. High expression of the ETS transcription factor ERG predicts adverse outcome in acute T-lymphoblastic leukemia in adults. J Clin Oncol. 2006;24:4714-20 pubmed
    ..We have determined the prognostic impact of the oncogenic transcription factor ERG in T-ALL...
  9. Mosquera J, Perner S, Genega E, Sanda M, Hofer M, Mertz K, et al. Characterization of TMPRSS2-ERG fusion high-grade prostatic intraepithelial neoplasia and potential clinical implications. Clin Cancer Res. 2008;14:3380-5 pubmed publisher
    ..The TMPRSS2-ERG gene fusion that has recently been described in prostate cancer has also been shown to occur in a subset of HGPIN...

More Information

Publications98

  1. Moore S, Offor O, Ferry J, Amrein P, Morton C, Dal Cin P. ELF4 is fused to ERG in a case of acute myeloid leukemia with a t(X;21)(q25-26;q22). Leuk Res. 2006;30:1037-42 pubmed
    ..t(X;21)(q25-26;q22), resulting in a fusion transcript between two ETS domain family members, ELF4 (at Xq25) and ERG (at 21q22)...
  2. Han B, Mehra R, Suleman K, Tomlins S, Wang L, Singhal N, et al. Characterization of ETS gene aberrations in select histologic variants of prostate carcinoma. Mod Pathol. 2009;22:1176-85 pubmed publisher
    ..Recently, recurrent gene fusions between the androgen-regulated gene TMPRSS2 and the ETS transcription factors ERG, ETV1, ETV4, or ETV5 have been identified in a majority of conventional prostate carcinomas...
  3. Liu W, Ewing C, Chang B, Li T, Sun J, Turner A, et al. Multiple genomic alterations on 21q22 predict various TMPRSS2/ERG fusion transcripts in human prostate cancers. Genes Chromosomes Cancer. 2007;46:972-80 pubmed
    A number of TMPRSS2/ERG fusion transcripts have been reported since the discovery that recurrent genomic rearrangements result in the fusion of TMPRSS2 and ETS family member genes...
  4. Marcucci G, Baldus C, Ruppert A, Radmacher M, Mrozek K, Whitman S, et al. Overexpression of the ETS-related gene, ERG, predicts a worse outcome in acute myeloid leukemia with normal karyotype: a Cancer and Leukemia Group B study. J Clin Oncol. 2005;23:9234-42 pubmed
    To test the prognostic significance of ETS-related gene (ERG) expression in cytogenetically normal primary acute myeloid leukemia (AML)...
  5. Furusato B, Tan S, Young D, Dobi A, Sun C, Mohamed A, et al. ERG oncoprotein expression in prostate cancer: clonal progression of ERG-positive tumor cells and potential for ERG-based stratification. Prostate Cancer Prostatic Dis. 2010;13:228-37 pubmed publisher
    Gene fusions prevalent in prostate cancer (CaP) lead to the elevated expression of the ERG proto-oncogene. ERG activation present in 50-70% of prostate tumors underscores one of the most common oncogenic alterations in CaP...
  6. Cerveira N, Ribeiro F, Peixoto A, Costa V, Henrique R, Jeronimo C, et al. TMPRSS2-ERG gene fusion causing ERG overexpression precedes chromosome copy number changes in prostate carcinomas and paired HGPIN lesions. Neoplasia. 2006;8:826-32 pubmed
    ..paired HGPIN lesions, 14 benign prostate hyperplasias, and 11 morphologically normal prostatic tissues for TMPRSS2-ERG and TMPRSS2-ETV1 rearrangements and genomic imbalances...
  7. Winnes M, Lissbrant E, Damber J, Stenman G. Molecular genetic analyses of the TMPRSS2-ERG and TMPRSS2-ETV1 gene fusions in 50 cases of prostate cancer. Oncol Rep. 2007;17:1033-6 pubmed
    ..Recurrent fusions were identified between the 5'-noncoding region of TMPRSS2 and ERG, or less frequently ETV1 or ETV4, resulting in overexpression of normal or truncated ETS-proteins...
  8. Rostad K, Mannelqvist M, Halvorsen O, Oyan A, Bø T, Stordrange L, et al. ERG upregulation and related ETS transcription factors in prostate cancer. Int J Oncol. 2007;30:19-32 pubmed
    ..genes most consistently and highly upregulated in prostate cancer was the ETS family transcription factor ERG (ETS related gene)...
  9. Rice K, Chen Y, Ali A, Whitman E, Blase A, Ibrahim M, et al. Evaluation of the ETS-related gene mRNA in urine for the detection of prostate cancer. Clin Cancer Res. 2010;16:1572-6 pubmed publisher
    ..androgen-regulated promoters (primarily TMPRSS2) and ETS transcription factors (predominantly ETS-regulated gene (ERG)], which result in tumor selective overexpression of ERG in two thirds of patients...
  10. Pflueger D, Rickman D, Sboner A, Perner S, Lafargue C, Svensson M, et al. N-myc downstream regulated gene 1 (NDRG1) is fused to ERG in prostate cancer. Neoplasia. 2009;11:804-11 pubmed
    ..transformation-specific rearrangements, most commonly fusing the androgen-regulated TMPRSS2 promoter to ERG. The TMPRSS2-ERG fusion is observed in around 90% of tumors that overexpress the oncogene ERG...
  11. Pettersson A, Graff R, Bauer S, Pitt M, Lis R, Stack E, et al. The TMPRSS2:ERG rearrangement, ERG expression, and prostate cancer outcomes: a cohort study and meta-analysis. Cancer Epidemiol Biomarkers Prev. 2012;21:1497-509 pubmed publisher
    ..genomic rearrangement transmembrane protease, serine 2 (TMPRSS2):v-ets erythroblastosis virus E26 oncogene homolog (ERG) has prognostic value in prostate cancer is unclear...
  12. Mehra R, Tomlins S, Yu J, Cao X, Wang L, Menon A, et al. Characterization of TMPRSS2-ETS gene aberrations in androgen-independent metastatic prostate cancer. Cancer Res. 2008;68:3584-90 pubmed publisher
    Recurrent gene fusions between the androgen-regulated gene TMPRSS2 and the ETS transcription factor family members ERG, ETV1, and ETV4 have been identified as a critical event in prostate cancer development...
  13. Furusato B, Gao C, Ravindranath L, Chen Y, Cullen J, McLeod D, et al. Mapping of TMPRSS2-ERG fusions in the context of multi-focal prostate cancer. Mod Pathol. 2008;21:67-75 pubmed
    TMPRSS2-ERG gene fusion leading to the androgenic induction of the ERG proto-oncogene expression is a highly prevalent oncogenic alteration in prostate tumor cells...
  14. Rostad K, Hellwinkel O, Haukaas S, Halvorsen O, Øyan A, Haese A, et al. TMPRSS2:ERG fusion transcripts in urine from prostate cancer patients correlate with a less favorable prognosis. APMIS. 2009;117:575-82 pubmed publisher
    The transcription factor ERG is highly upregulated in the majority of prostate cancers due to chromosomal fusion of the androgen responsive promoter of TMPRSS2 to the ERG reading frame...
  15. FitzGerald L, Agalliu I, Johnson K, Miller M, Kwon E, Hurtado Coll A, et al. Association of TMPRSS2-ERG gene fusion with clinical characteristics and outcomes: results from a population-based study of prostate cancer. BMC Cancer. 2008;8:230 pubmed publisher
    The presence of the TMPRSS2-ERG fusion gene in prostate tumors has recently been associated with an aggressive phenotype, as well as recurrence and death from prostate cancer...
  16. Attard G, Swennenhuis J, Olmos D, Reid A, Vickers E, A Hern R, et al. Characterization of ERG, AR and PTEN gene status in circulating tumor cells from patients with castration-resistant prostate cancer. Cancer Res. 2009;69:2912-8 pubmed publisher
    Hormone-driven expression of the ERG oncogene after fusion with TMPRSS2 occurs in 30% to 70% of therapy-naive prostate cancers...
  17. Mani R, Iyer M, Cao Q, Brenner J, Wang L, Ghosh A, et al. TMPRSS2-ERG-mediated feed-forward regulation of wild-type ERG in human prostate cancers. Cancer Res. 2011;71:5387-92 pubmed publisher
    ..gene fusions involving ETS family genes are a distinguishing feature of human prostate cancers, with TMPRSS2-ERG fusions representing the most common subtype...
  18. Flajollet S, Tian T, Flourens A, Tomavo N, Villers A, Bonnelye E, et al. Abnormal expression of the ERG transcription factor in prostate cancer cells activates osteopontin. Mol Cancer Res. 2011;9:914-24 pubmed publisher
    ..The most frequently identified fusion gene is TMPRSS2:ERG, which causes ERG protein overexpression in PCa cells. ERG is a transcription factor linked to skeletogenesis...
  19. Saramäki O, Harjula A, Martikainen P, Vessella R, Tammela T, Visakorpi T. TMPRSS2:ERG fusion identifies a subgroup of prostate cancers with a favorable prognosis. Clin Cancer Res. 2008;14:3395-400 pubmed publisher
    Our aim was to assess the frequency of ERG overexpression and TMPRSS2:ERG rearrangement in prostate cancer and their association with clinicopathologic variables and outcome...
  20. Diffner E, Beck D, Gudgin E, Thoms J, Knezevic K, Pridans C, et al. Activity of a heptad of transcription factors is associated with stem cell programs and clinical outcome in acute myeloid leukemia. Blood. 2013;121:2289-300 pubmed publisher
    ..b>Ets Related Gene (ERG) is a component of normal and leukemic stem cell signatures and high ERG expression is a risk factor ..
  21. Mosquera J, Mehra R, Regan M, Perner S, Genega E, Bueti G, et al. Prevalence of TMPRSS2-ERG fusion prostate cancer among men undergoing prostate biopsy in the United States. Clin Cancer Res. 2009;15:4706-11 pubmed publisher
    Fusion of the TMPRSS2 prostate-specific gene with the ERG transcription factor is a putatively oncogenic gene rearrangement that is commonly found in prostate cancer tissue from men undergoing prostatectomy...
  22. Fine S, Gopalan A, Leversha M, Al Ahmadie H, Tickoo S, Zhou Q, et al. TMPRSS2-ERG gene fusion is associated with low Gleason scores and not with high-grade morphological features. Mod Pathol. 2010;23:1325-33 pubmed publisher
    TMPRSS2-ERG gene rearrangement is seen in about half of clinically localized prostate cancers, yet controversy exists with regard to its prognostic implications...
  23. Gopalan A, Leversha M, Satagopan J, Zhou Q, Al Ahmadie H, Fine S, et al. TMPRSS2-ERG gene fusion is not associated with outcome in patients treated by prostatectomy. Cancer Res. 2009;69:1400-6 pubmed publisher
    ..fusion of the androgen-regulated TMPRSS2 promoter to a member of the ETS transcription factor family, most commonly ERG. This results in ERG overexpression, which may have a direct causal role in prostate tumorigenesis or progression...
  24. Wang J, Cai Y, Shao L, Siddiqui J, Palanisamy N, Li R, et al. Activation of NF-{kappa}B by TMPRSS2/ERG Fusion Isoforms through Toll-Like Receptor-4. Cancer Res. 2011;71:1325-33 pubmed publisher
    The TMPRSS2/ERG (T/E) fusion gene is present and thought to be an oncogenic driver of approximately half of all prostate cancers...
  25. Rao V, Papas T, Reddy E. erg, a human ets-related gene on chromosome 21: alternative splicing, polyadenylation, and translation. Science. 1987;237:635-9 pubmed
    ..Recently, a novel gene named erg, closely related to the v-ets oncogene, was identified in human COLO 320 cells and the nucleotide sequence of its ..
  26. Guo C, Dancer J, Wang Y, Aparicio A, Navone N, Troncoso P, et al. TMPRSS2-ERG gene fusion in small cell carcinoma of the prostate. Hum Pathol. 2011;42:11-7 pubmed publisher
    Recent studies have shown that most prostate cancers carry the TMPRSS2-ERG gene fusion...
  27. Tu J, Rohan S, Kao J, Kitabayashi N, Mathew S, Chen Y. Gene fusions between TMPRSS2 and ETS family genes in prostate cancer: frequency and transcript variant analysis by RT-PCR and FISH on paraffin-embedded tissues. Mod Pathol. 2007;20:921-8 pubmed
    ..In this study, we used formalin-fixed paraffin-embedded tissue and evaluated both TMPRSS2-ERG and TMPRSS2-ETV1 fusions by reverse transcription polymerase chain reaction (RT-PCR) and fluorescence in situ ..
  28. Salami S, Schmidt F, Laxman B, Regan M, Rickman D, Scherr D, et al. Combining urinary detection of TMPRSS2:ERG and PCA3 with serum PSA to predict diagnosis of prostate cancer. Urol Oncol. 2013;31:566-71 pubmed publisher
    We sought to develop a clinical algorithm combining serum PSA with detection of TMPRSS2:ERG fusion and PCA3 in urine collected after digital rectal exam (post-DRE urine) to predict prostate cancer on subsequent biopsy...
  29. Yaskiv O, Zhang X, Simmerman K, Daly T, He H, Falzarano S, et al. The utility of ERG/P63 double immunohistochemical staining in the diagnosis of limited cancer in prostate needle biopsies. Am J Surg Pathol. 2011;35:1062-8 pubmed publisher
    ..Recently, TMPRSS2:ERG gene rearrangement was found to be highly specific for and detected in approximately 50% of prostate cancer...
  30. Börno S, Fischer A, Kerick M, Fälth M, Laible M, Brase J, et al. Genome-wide DNA methylation events in TMPRSS2-ERG fusion-negative prostate cancers implicate an EZH2-dependent mechanism with miR-26a hypermethylation. Cancer Discov. 2012;2:1024-35 pubmed publisher
    ..In addition, global methylation patterns show significant differences based on the TMPRSS2-ERG rearrangement status...
  31. Carrere S, Verger A, Flourens A, Stehelin D, Duterque Coquillaud M. Erg proteins, transcription factors of the Ets family, form homo, heterodimers and ternary complexes via two distinct domains. Oncogene. 1998;16:3261-8 pubmed
    ..We report here that the Erg proteins, members of the Ets family, form homo and heterodimeric complexes in vitro...
  32. Esgueva R, Perner S, J LaFargue C, Scheble V, Stephan C, Lein M, et al. Prevalence of TMPRSS2-ERG and SLC45A3-ERG gene fusions in a large prostatectomy cohort. Mod Pathol. 2010;23:539-46 pubmed publisher
    ..fusions between the hormone-regulated TMPRSS2 and members of the ETS family of transcription factors, most commonly ERG. Prostate cancer with ERG rearrangements represent a distinct sub-class of tumor based on studies reporting ..
  33. Basuyaux J, Ferreira E, Stehelin D, Buttice G. The Ets transcription factors interact with each other and with the c-Fos/c-Jun complex via distinct protein domains in a DNA-dependent and -independent manner. J Biol Chem. 1997;272:26188-95 pubmed
    ..Recently, we found that ERG, an Ets family member, activates collagenase-1 gene but not stromelysin-1 by physically interacting with c-Fos/c-..
  34. Karnes R, Cheville J, Ida C, Sebo T, Nair A, Tang H, et al. The ability of biomarkers to predict systemic progression in men with high-risk prostate cancer treated surgically is dependent on ERG status. Cancer Res. 2010;70:8994-9002 pubmed publisher
    The objective of this study was to assess the relationship of the tumor protein levels of TOP2A and MIB-1 and ERG status with cancer-specific outcomes in men with high-risk prostate cancer treated by radical prostatectomy (RP)...
  35. Thoms J, Birger Y, Foster S, Knezevic K, Kirschenbaum Y, Chandrakanthan V, et al. ERG promotes T-acute lymphoblastic leukemia and is transcriptionally regulated in leukemic cells by a stem cell enhancer. Blood. 2011;117:7079-89 pubmed publisher
    The Ets-related gene (ERG) is an Ets-transcription factor required for normal blood stem cell development...
  36. Minner S, Luebke A, Kluth M, Bokemeyer C, Janicke F, Izbicki J, et al. High level of Ets-related gene expression has high specificity for prostate cancer: a tissue microarray study of 11 483 cancers. Histopathology. 2012;61:445-53 pubmed publisher
    TMPRSS2-ERG fusion resulting in strong Ets-related gene (ERG) overexpression occurs in about 50% of prostate cancers...
  37. Grasso C, Wu Y, Robinson D, Cao X, Dhanasekaran S, Khan A, et al. The mutational landscape of lethal castration-resistant prostate cancer. Nature. 2012;487:239-43 pubmed publisher
    ..Similarly, we demonstrate that ETS2, which is deleted in approximately one-third of CRPCs (commonly through TMPRSS2:ERG fusions), is also deregulated through mutation...
  38. Reddy E, Rao V, Papas T. The erg gene: a human gene related to the ets oncogene. Proc Natl Acad Sci U S A. 1987;84:6131-5 pubmed
    We have isolated a cDNA clone representing the complete coding sequence of a human gene named erg, related to the ets oncogene. Nucleotide sequence analysis of this cDNA (4...
  39. Soller M, Isaksson M, Elfving P, Soller W, Lundgren R, Panagopoulos I. Confirmation of the high frequency of the TMPRSS2/ERG fusion gene in prostate cancer. Genes Chromosomes Cancer. 2006;45:717-9 pubmed
  40. Owczarek C, Portbury K, Hardy M, O Leary D, Kudoh J, Shibuya K, et al. Detailed mapping of the ERG-ETS2 interval of human chromosome 21 and comparison with the region of conserved synteny on mouse chromosome 16. Gene. 2004;324:65-77 pubmed
    We have carried out a detailed annotation of 550 kb of genomic DNA on human chromosome 21 containing the ERG and ETS2 genes...
  41. Han B, Mehra R, Lonigro R, Wang L, Suleman K, Menon A, et al. Fluorescence in situ hybridization study shows association of PTEN deletion with ERG rearrangement during prostate cancer progression. Mod Pathol. 2009;22:1083-93 pubmed publisher
    The link between ERG rearrangement and PTEN (phosphatase and tensin homolog deleted on chromosome 10) deletion is unclear in prostate cancer progression...
  42. Bonaccorsi L, Nesi G, Nuti F, Paglierani M, Krausz C, Masieri L, et al. Persistence of expression of the TMPRSS2:ERG fusion gene after pre-surgery androgen ablation may be associated with early prostate specific antigen relapse of prostate cancer: preliminary results. J Endocrinol Invest. 2009;32:590-6 pubmed publisher
    The recently identified TMPRSS2: ERG fusion gene is a candidate oncogene for prostate cancer (PCa). We have tested for the presence of this gene in tumor samples from 84 patients who had radical prostatectomy in 1998-2000...
  43. Birdsey G, Dryden N, Amsellem V, Gebhardt F, Sahnan K, Haskard D, et al. Transcription factor Erg regulates angiogenesis and endothelial apoptosis through VE-cadherin. Blood. 2008;111:3498-506 pubmed publisher
    ..The ETS transcription factor Erg is required for endothelial tube formation in vitro...
  44. Casey O, Fang L, Hynes P, Abou Kheir W, Martin P, Tillman H, et al. TMPRSS2- driven ERG expression in vivo increases self-renewal and maintains expression in a castration resistant subpopulation. PLoS ONE. 2012;7:e41668 pubmed publisher
    ..prostate cancer, the fusion of the promoter region of TMPRSS2 with the coding region of the transcription factor, ERG. A recombinant bacterial artificial chromosome including an extended TMPRSS2 promoter driving genomic ERG was ..
  45. Rickman D, Chen Y, Banerjee S, Pan Y, Yu J, Vuong T, et al. ERG cooperates with androgen receptor in regulating trefoil factor 3 in prostate cancer disease progression. Neoplasia. 2010;12:1031-40 pubmed
    ..Trefoil factor 3 (TFF3) emerged as the most highly differentially regulated gene with respect to ERG rearrangement status and resistance to hormone ablation therapy...
  46. Bock J, Mochmann L, Schlee C, Farhadi Sartangi N, Göllner S, Muller Tidow C, et al. ERG transcriptional networks in primary acute leukemia cells implicate a role for ERG in deregulated kinase signaling. PLoS ONE. 2013;8:e52872 pubmed publisher
    High expression of the E26 transforming sequence related gene (ERG) is associated with poor prognosis in a subgroup of leukemia patients with acute myeloid (AML) and acute T-lymphoblastic leukemia (T-ALL)...
  47. Rubio Briones J, Fernandez Serra A, Calatrava A, Garcia Casado Z, Rubio L, Bonillo M, et al. Clinical implications of TMPRSS2-ERG gene fusion expression in patients with prostate cancer treated with radical prostatectomy. J Urol. 2010;183:2054-61 pubmed publisher
    ..We analyzed the association of the TMPRSS2-ERG fusion gene with prostate cancer outcome in patients treated with radical prostatectomy...
  48. Schaefer G, Mosquera J, Ramoner R, Park K, Romanel A, Steiner E, et al. Distinct ERG rearrangement prevalence in prostate cancer: higher frequency in young age and in low PSA prostate cancer. Prostate Cancer Prostatic Dis. 2013;16:132-8 pubmed publisher
    The TMPRSS2-ERG gene fusion resulting in ERG overexpression has been found in around 50% of prostate cancers (PCa) and is a very early event in tumorigenesis...
  49. Chaux A, Albadine R, Toubaji A, Hicks J, Meeker A, Platz E, et al. Immunohistochemistry for ERG expression as a surrogate for TMPRSS2-ERG fusion detection in prostatic adenocarcinomas. Am J Surg Pathol. 2011;35:1014-20 pubmed publisher
    TMPRSS2-ERG fusions have been identified in about one-half of all prostatic adenocarcinomas (PCas)...
  50. Cai C, Wang H, He H, Chen S, He L, Ma F, et al. ERG induces androgen receptor-mediated regulation of SOX9 in prostate cancer. J Clin Invest. 2013;123:1109-22 pubmed publisher
    Fusion of the androgen receptor-regulated (AR-regulated) TMPRSS2 gene with ERG in prostate cancer (PCa) causes androgen-stimulated overexpression of ERG, an ETS transcription factor, but critical downstream effectors of ERG-mediating PCa ..
  51. Rahim S, Beauchamp E, Kong Y, Brown M, Toretsky J, Uren A. YK-4-279 inhibits ERG and ETV1 mediated prostate cancer cell invasion. PLoS ONE. 2011;6:e19343 pubmed publisher
    Genomic rearrangements involving the ETS family of transcription factors occur in 40-70% of prostate cancer cases. ERG and ETV1 are the most common ETS members observed in these genetic alterations...
  52. Yoshimoto M, Joshua A, Chilton MacNeill S, Bayani J, Selvarajah S, Evans A, et al. Three-color FISH analysis of TMPRSS2/ERG fusions in prostate cancer indicates that genomic microdeletion of chromosome 21 is associated with rearrangement. Neoplasia. 2006;8:465-9 pubmed
    ..Analysis of 15 PCa cases by reverse transcription-polymerase chain reaction was used to detect six ERG-related gene fusion transcripts with TMPRSS2. No TMPRSS2/ETV1 chimeric fusion was detected in this series...
  53. Setlur S, Mertz K, Hoshida Y, Demichelis F, Lupien M, Perner S, et al. Estrogen-dependent signaling in a molecularly distinct subclass of aggressive prostate cancer. J Natl Cancer Inst. 2008;100:815-25 pubmed publisher
    ..The common fusion between TMPRESS2 and v-ets erythroblastosis virus E26 oncogene homolog (avian) (ERG) is associated with a more aggressive clinical phenotype, implying the existence of a distinct subclass of prostate ..
  54. Tomlins S, Rhodes D, Perner S, Dhanasekaran S, Mehra R, Sun X, et al. Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer. Science. 2005;310:644-8 pubmed
    ..Two ETS transcription factors, ERG and ETV1, were identified as outliers in prostate cancer...
  55. Sperone A, Dryden N, Birdsey G, Madden L, Johns M, Evans P, et al. The transcription factor Erg inhibits vascular inflammation by repressing NF-kappaB activation and proinflammatory gene expression in endothelial cells. Arterioscler Thromb Vasc Biol. 2011;31:142-50 pubmed publisher
    To test whether ETS-related gene (Erg) inhibits tumor necrosis factor (TNF)-?-dependent endothelial activation and inflammation. Endothelial activation underlies many vascular diseases, including atherosclerosis...
  56. Park K, Tomlins S, Mudaliar K, Chiu Y, Esgueva R, Mehra R, et al. Antibody-based detection of ERG rearrangement-positive prostate cancer. Neoplasia. 2010;12:590-8 pubmed
    TMPRSS2-ERG gene fusions occur in 50% of prostate cancers and result in the overexpression of a chimeric fusion transcript that encodes a truncated ERG product...
  57. McLaughlin F, Ludbrook V, Kola I, Campbell C, Randi A. Characterisation of the tumour necrosis factor (TNF)-(alpha) response elements in the human ICAM-2 promoter. J Cell Sci. 1999;112 ( Pt 24):4695-703 pubmed
    ..The Ets family member Erg was found to be constitutively expressed in HUVEC, and TNF-(alpha) down-regulated Erg protein levels...
  58. Prasad D, Rao V, Lee L, Reddy E. Differentially spliced erg-3 product functions as a transcriptional activator. Oncogene. 1994;9:669-73 pubmed
    ..Previously, we have identified a member of this ets superfamily namely erg, ets related gene...
  59. Hofer M, Kuefer R, Maier C, Herkommer K, Perner S, Demichelis F, et al. Genome-wide linkage analysis of TMPRSS2-ERG fusion in familial prostate cancer. Cancer Res. 2009;69:640-6 pubmed publisher
    ..family members is found frequently in prostate cancers, and recent work suggests that the most common TMPRSS2-ERG fusion is associated with an aggressive clinical phenotype compared with fusion-negative prostate cancer...
  60. Schwind S, Marcucci G, Maharry K, Radmacher M, Mrozek K, Holland K, et al. BAALC and ERG expression levels are associated with outcome and distinct gene and microRNA expression profiles in older patients with de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study. Blood. 2010;116:5660-9 pubmed publisher
    BAALC and ERG expression levels are prognostic markers in younger (< 60 years) cytogenetically normal acute myeloid leukemia (CN-AML) adults; their prognostic impact in older (? 60 years) patients requires further investigation...
  61. Demichelis F, Setlur S, Beroukhim R, Perner S, Korbel J, Lafargue C, et al. Distinct genomic aberrations associated with ERG rearranged prostate cancer. Genes Chromosomes Cancer. 2009;48:366-80 pubmed publisher
    ..Co-occurring events included losses at 19q13.32 and 1p22.1. We discovered three genomic events associated with ERG rearranged prostate cancer, affecting 6q, 7q, and 16q...
  62. Chng K, Chang C, Tan S, Yang C, Hong S, Sng N, et al. A transcriptional repressor co-regulatory network governing androgen response in prostate cancers. EMBO J. 2012;31:2810-23 pubmed publisher
    ..Using ChIP-Seq, we generated extensive global binding maps of AR, ERG, and commonly over-expressed transcriptional corepressors including HDAC1, HDAC2, HDAC3, and EZH2 in prostate ..
  63. Yu J, Yu J, Mani R, Cao Q, Brenner C, Cao X, et al. An integrated network of androgen receptor, polycomb, and TMPRSS2-ERG gene fusions in prostate cancer progression. Cancer Cell. 2010;17:443-54 pubmed publisher
    Chromosomal rearrangements fusing the androgen-regulated gene TMPRSS2 to the oncogenic ETS transcription factor ERG occur in approximately 50% of prostate cancers, but how the fusion products regulate prostate cancer remains unclear...
  64. Hoogland A, Jenster G, Van Weerden W, Trapman J, van der Kwast T, Roobol M, et al. ERG immunohistochemistry is not predictive for PSA recurrence, local recurrence or overall survival after radical prostatectomy for prostate cancer. Mod Pathol. 2012;25:471-9 pubmed publisher
    ..androgen-regulated transmembrane protease, serine 2 (TMPRSS2)-v-ets erythroblastosis virus E26 oncogen homologue (ERG) gene fusion occurring in 40-70%...
  65. Duterque Coquillaud M, Niel C, Plaza S, Stehelin D. New human erg isoforms generated by alternative splicing are transcriptional activators. Oncogene. 1993;8:1865-73 pubmed
    The erg gene is a member of the ets gene family. ETS proteins have been shown to bind specifically the (GGA-A/T) motif and to transactivate via this consensus sequence...
  66. Clark J, Attard G, Jhavar S, Flohr P, Reid A, de Bono J, et al. Complex patterns of ETS gene alteration arise during cancer development in the human prostate. Oncogene. 2008;27:1993-2003 pubmed
    An ERG gene 'break-apart' fluorescence in situ hybridization (FISH) assay has been used to screen whole-mount prostatectomy specimens for rearrangements at the ERG locus...
  67. Lu B, Maqsodi B, Yang W, McMaster G, Perner S, Regan M, et al. Detection of TMPRSS2-ERG fusion gene expression in prostate cancer specimens by a novel assay using branched DNA. Urology. 2009;74:1156-61 pubmed publisher
    To develop a novel assay that uses branched DNA technology to measure TMPRSS2-ERG fusion, as genetic rearrangement of TMPRSS2 regulatory sequences and coding sequences of the ERG gene has been detected in nearly half of prostate cancers, ..
  68. Mani R, Tomlins S, Callahan K, Ghosh A, Nyati M, Varambally S, et al. Induced chromosomal proximity and gene fusions in prostate cancer. Science. 2009;326:1230 pubmed publisher
    ..involving the 5' untranslated region of TMPRSS2, an androgen-regulated gene, and the protein-coding sequences of ERG, which encodes an erythroblast transformation-specific (ETS) transcription factor...
  69. Rickman D, Soong T, Moss B, Mosquera J, Dlabal J, Terry S, et al. Oncogene-mediated alterations in chromatin conformation. Proc Natl Acad Sci U S A. 2012;109:9083-8 pubmed publisher
    ..we performed unbiased high-resolution mapping of intra- and interchromosome interactions upon overexpression of ERG, an oncogenic transcription factor frequently overexpressed in prostate cancer as a result of a gene fusion...
  70. Chen Y, Chi P, Rockowitz S, Iaquinta P, Shamu T, Shukla S, et al. ETS factors reprogram the androgen receptor cistrome and prime prostate tumorigenesis in response to PTEN loss. Nat Med. 2013;19:1023-9 pubmed publisher
    ..Here we describe a new conditional mouse model that shows robust, homogenous ERG expression throughout the prostate...
  71. Danila D, Anand A, Sung C, Heller G, Leversha M, Cao L, et al. TMPRSS2-ERG status in circulating tumor cells as a predictive biomarker of sensitivity in castration-resistant prostate cancer patients treated with abiraterone acetate. Eur Urol. 2011;60:897-904 pubmed publisher
    ..To study the role of transmembrane protease, serine 2 (TMPRSS2)-v-ets erythroblastosis virus E26 oncogene homolog (ERG) fusion, an androgen-dependent growth factor, in circulating tumor cells (CTCs) as a biomarker of sensitivity to AA...
  72. Rouzier C, Haudebourg J, Carpentier X, Valerio L, Amiel J, Michiels J, et al. Detection of the TMPRSS2-ETS fusion gene in prostate carcinomas: retrospective analysis of 55 formalin-fixed and paraffin-embedded samples with clinical data. Cancer Genet Cytogenet. 2008;183:21-7 pubmed publisher
    ..We identified the fusion gene TMPRSS2-ERG by reverse-transcriptase polymerase chain reaction (RT-PCR) in 40/55 carcinomas (72%)...
  73. Perner S, Svensson M, Hossain R, Day J, Groskopf J, Slaughter R, et al. ERG rearrangement metastasis patterns in locally advanced prostate cancer. Urology. 2010;75:762-7 pubmed publisher
    To interrogate multifocal prostate cancer (PCa) to determine its predilection for metastasis, using ERG rearrangement as marker of clonality...
  74. Leinonen K, Tolonen T, Bracken H, Stenman U, Tammela T, Saramäki O, et al. Association of SPINK1 expression and TMPRSS2:ERG fusion with prognosis in endocrine-treated prostate cancer. Clin Cancer Res. 2010;16:2845-51 pubmed publisher
    The aim of the study was to examine whether TMPRSS2:ERG fusion or SPINK1 protein expression is associated with hormone responsiveness of prostate cancer and can thus be used as a biomarker...
  75. Bismar T, Yoshimoto M, Vollmer R, Duan Q, Firszt M, Corcos J, et al. PTEN genomic deletion is an early event associated with ERG gene rearrangements in prostate cancer. BJU Int. 2011;107:477-85 pubmed publisher
    To investigate the interaction between, and significance of, ERG gene rearrangements and PTEN genomic deletions in relation to the development and progression of prostate cancer (PCA)...
  76. Darnel A, Lafargue C, Vollmer R, Corcos J, Bismar T. TMPRSS2-ERG fusion is frequently observed in Gleason pattern 3 prostate cancer in a Canadian cohort. Cancer Biol Ther. 2009;8:125-30 pubmed
    TMPRSS2-ERG gene fusion was recently reported as the most common gene rearrangement in prostate cancer (PCA). In this cohort 41% of the patients showed positive gene fusion status in their PCA...
  77. Falzarano S, Zhou M, Hernandez A, Klein E, Rubin M, Magi Galluzzi C. Single focus prostate cancer: pathological features and ERG fusion status. J Urol. 2011;185:489-94 pubmed publisher
    ..of single focus prostate cancer in radical prostatectomies, its clinical relevance and the occurrence of TMPRSS2-ERG rearrangement...
  78. He H, Magi Galluzzi C, Li J, Carver P, Falzarano S, Smith K, et al. The diagnostic utility of novel immunohistochemical marker ERG in the workup of prostate biopsies with "atypical glands suspicious for cancer". Am J Surg Pathol. 2011;35:608-14 pubmed publisher
    ..TMPRSS2:ERG gene rearrangement is the most common chromosomal alteration and is highly specific for PCa...
  79. Toubaji A, Albadine R, Meeker A, Isaacs W, Lotan T, Haffner M, et al. Increased gene copy number of ERG on chromosome 21 but not TMPRSS2-ERG fusion predicts outcome in prostatic adenocarcinomas. Mod Pathol. 2011;24:1511-20 pubmed publisher
    The role of TMPRSS2-ERG gene fusion in prostate cancer prognostication remains controversial...
  80. Yang L, Xia L, Wu D, Wang H, Chansky H, Schubach W, et al. Molecular cloning of ESET, a novel histone H3-specific methyltransferase that interacts with ERG transcription factor. Oncogene. 2002;21:148-52 pubmed
    The ets-related gene erg encodes a transcription factor that is implicated in the control of cell growth and differentiation...
  81. Hu Y, Dobi A, Sreenath T, Cook C, Tadase A, Ravindranath L, et al. Delineation of TMPRSS2-ERG splice variants in prostate cancer. Clin Cancer Res. 2008;14:4719-25 pubmed publisher
    ..cells from 122 patients, relative abundance of these variants was in the following order: ERG8 > TEPC > ERG 3 > ERG1/2 with combined overexpression rate of 62.3% in prostate cancer...
  82. Mochmann L, Bock J, Ortiz Tánchez J, Schlee C, Bohne A, Neumann K, et al. Genome-wide screen reveals WNT11, a non-canonical WNT gene, as a direct target of ETS transcription factor ERG. Oncogene. 2011;30:2044-56 pubmed publisher
    E26 transforming sequence-related gene (ERG) is a transcription factor involved in normal hematopoiesis and is dysregulated in leukemia...
  83. Scheble V, Braun M, Beroukhim R, Mermel C, Ruiz C, Wilbertz T, et al. ERG rearrangement is specific to prostate cancer and does not occur in any other common tumor. Mod Pathol. 2010;23:1061-7 pubmed publisher
    ..The recently discovered recurrent ERG rearrangement in prostate cancer might represent a prostate cancer-specific alteration that has not been ..
  84. Eid M, Attia M, Abdou S, El Shazly S, Elahwal L, Farrag W, et al. BAALC and ERG expression in acute myeloid leukemia with normal karyotype: impact on prognosis. Int J Lab Hematol. 2010;32:197-205 pubmed publisher
    ..We studied the prognostic impact of brain and acute leukemia, cytoplasmic (BAALC) and ETS-related gene (ERG) expression in AML with normal karyotype...
  85. Hermans K, Boormans J, Gasi D, van Leenders G, Jenster G, Verhagen P, et al. Overexpression of prostate-specific TMPRSS2(exon 0)-ERG fusion transcripts corresponds with favorable prognosis of prostate cancer. Clin Cancer Res. 2009;15:6398-403 pubmed publisher
    To gain insight in the mechanism and clinical relevance of TMPRSS2-ERG expression in prostate cancer, we determined the specific characteristics of fusion transcripts starting at TMPRSS2 exon 1 and at a more upstream and less ..
  86. Ichikawa H, Shimizu K, Hayashi Y, Ohki M. An RNA-binding protein gene, TLS/FUS, is fused to ERG in human myeloid leukemia with t(16;21) chromosomal translocation. Cancer Res. 1994;54:2865-8 pubmed
    ..have previously demonstrated that the breakpoints of this translocation are clustered in a specific intron of the ERG gene on chromosome 21, which has recently been reported to be involved in Ewing's sarcoma...
  87. Minner S, Gartner M, Freudenthaler F, Bauer M, Kluth M, Salomon G, et al. Marked heterogeneity of ERG expression in large primary prostate cancers. Mod Pathol. 2013;26:106-16 pubmed publisher
    Approximately 50% of prostate cancers are characterized by TMPRSS2 (transmembrane protease serine 2)-ERG (avian v-ets erythroblastosis virus E26 oncogene homolog) gene fusions resulting in an androgen-regulated overexpression of the ..
  88. Reid A, Attard G, Ambroisine L, Fisher G, Kovacs G, Brewer D, et al. Molecular characterisation of ERG, ETV1 and PTEN gene loci identifies patients at low and high risk of death from prostate cancer. Br J Cancer. 2010;102:678-84 pubmed publisher
    The discovery of ERG/ETV1 gene rearrangements and PTEN gene loss warrants investigation in a mechanism-based prognostic classification of prostate cancer (PCa)...
  89. Singareddy R, Semaan L, Conley LaComb M, St John J, Powell K, Iyer M, et al. Transcriptional regulation of CXCR4 in prostate cancer: significance of TMPRSS2-ERG fusions. Mol Cancer Res. 2013;11:1349-61 pubmed publisher
    ..Previously, we and others have shown that the transcription factor ERG regulates CXCR4 expression in prostate cancer cells and that androgens modulate CXCR4 expression via increasing ERG ..