ER

Summary

Gene Symbol: ER
Description: estrogen receptor 1
Alias: ESR, ESRA, ESTRR, Era, NR3A1, estrogen receptor, E2 receptor alpha, ER-alpha, estradiol receptor, estrogen nuclear receptor alpha, estrogen receptor alpha E1-E2-1-2, estrogen receptor alpha E1-N2-E2-1-2, nuclear receptor subfamily 3 group A member 1, oestrogen receptor alpha
Species: human

Top Publications

  1. ncbi Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: a new model for anti-estrogen resistance
    R A Campbell
    Department of Surgery, Indiana University School of Medicine, Indianapolis 46202, USA
    J Biol Chem 276:9817-24. 2001
  2. pmc Genome-wide association study identifies a new breast cancer susceptibility locus at 6q25.1
    Wei Zheng
    Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Nat Genet 41:324-8. 2009
  3. pmc Variants in the estrogen receptor alpha gene and its mRNA contribute to risk for schizophrenia
    Cynthia Shannon Weickert
    MiNDS Unit, Section on Neuropathology, GCAP, NIMH, NIH, Bethesda, MD 20892, USA
    Hum Mol Genet 17:2293-309. 2008
  4. ncbi Estrogen receptor-alpha directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter
    Raphaël Métivier
    European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Cell 115:751-63. 2003
  5. pmc Growth factor stimulation induces a distinct ER(alpha) cistrome underlying breast cancer endocrine resistance
    Mathieu Lupien
    Division of Molecular and Cellular Oncology, Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Genes Dev 24:2219-27. 2010
  6. pmc A variant of estrogen receptor-{alpha}, hER-{alpha}36: transduction of estrogen- and antiestrogen-dependent membrane-initiated mitogenic signaling
    Zhaoyi Wang
    Cancer Center, Creighton University, 2500 California Plaza, Omaha, NE 68178, USA
    Proc Natl Acad Sci U S A 103:9063-8. 2006
  7. ncbi Cyclic, proteasome-mediated turnover of unliganded and liganded ERalpha on responsive promoters is an integral feature of estrogen signaling
    George Reid
    European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69117, Heidelberg, Germany
    Mol Cell 11:695-707. 2003
  8. ncbi A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors
    Y Kamei
    Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, La Jolla, 92093 0648, USA
    Cell 85:403-14. 1996
  9. doi Role of the oestrogen receptor (ESR1 PvuII and ESR1 325 C->G) and progesterone receptor (PROGINS) polymorphisms in genetic susceptibility to migraine in a North Indian population
    G Joshi
    Department of Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
    Cephalalgia 30:311-20. 2010
  10. doi Estrogen receptor (ER) mRNA and ER-related gene expression in breast cancers that are 1% to 10% ER-positive by immunohistochemistry
    Takayuki Iwamoto
    The University of Texas MD Anderson Cancer Center, Houston, TX 77230 1439, USA
    J Clin Oncol 30:729-34. 2012

Research Grants

Detail Information

Publications545 found, 100 shown here

  1. ncbi Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: a new model for anti-estrogen resistance
    R A Campbell
    Department of Surgery, Indiana University School of Medicine, Indianapolis 46202, USA
    J Biol Chem 276:9817-24. 2001
    ..Anti-estrogens such as tamoxifen inhibit the growth of ER-positive breast cancers by reducing the expression of estrogen-regulated genes...
  2. pmc Genome-wide association study identifies a new breast cancer susceptibility locus at 6q25.1
    Wei Zheng
    Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Nat Genet 41:324-8. 2009
    ..SNP rs2046210 at 6q25.1, located upstream of the gene encoding estrogen receptor alpha (ESR1), showed strong and consistent association with breast cancer across all three stages...
  3. pmc Variants in the estrogen receptor alpha gene and its mRNA contribute to risk for schizophrenia
    Cynthia Shannon Weickert
    MiNDS Unit, Section on Neuropathology, GCAP, NIMH, NIH, Bethesda, MD 20892, USA
    Hum Mol Genet 17:2293-309. 2008
    ..We hypothesized that the variation in the estrogen receptor alpha (ESR1) gene and cortical ESR1 mRNA is associated with schizophrenia...
  4. ncbi Estrogen receptor-alpha directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter
    Raphaël Métivier
    European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Cell 115:751-63. 2003
    ..a comprehensive picture of events resulting in transcriptional activation of a gene, through evaluating the estrogen receptor-alpha (NR3A1) target pS2 gene promoter in MCF-7 cells...
  5. pmc Growth factor stimulation induces a distinct ER(alpha) cistrome underlying breast cancer endocrine resistance
    Mathieu Lupien
    Division of Molecular and Cellular Oncology, Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Genes Dev 24:2219-27. 2010
    b>Estrogen receptor α (ERα) expression in breast cancer is predictive of response to endocrine therapy; however, resistance is common in ERα-positive tumors that overexpress the growth factor receptor ERBB2...
  6. pmc A variant of estrogen receptor-{alpha}, hER-{alpha}36: transduction of estrogen- and antiestrogen-dependent membrane-initiated mitogenic signaling
    Zhaoyi Wang
    Cancer Center, Creighton University, 2500 California Plaza, Omaha, NE 68178, USA
    Proc Natl Acad Sci U S A 103:9063-8. 2006
    The status of the 66-kDa human estrogen receptor-alpha (hER-alpha66) is a critical determinant in the assessment of the prognosis and in the design of treatment strategies of human breast cancer...
  7. ncbi Cyclic, proteasome-mediated turnover of unliganded and liganded ERalpha on responsive promoters is an integral feature of estrogen signaling
    George Reid
    European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69117, Heidelberg, Germany
    Mol Cell 11:695-707. 2003
    ..Cyclic turnover of hERalpha permits continuous responses to changes in the concentration of estradiol...
  8. ncbi A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors
    Y Kamei
    Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, La Jolla, 92093 0648, USA
    Cell 85:403-14. 1996
    ....
  9. doi Role of the oestrogen receptor (ESR1 PvuII and ESR1 325 C->G) and progesterone receptor (PROGINS) polymorphisms in genetic susceptibility to migraine in a North Indian population
    G Joshi
    Department of Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
    Cephalalgia 30:311-20. 2010
    ..304, 3.464) when compared with HC. No risk was observed when TTH patients were compared with HC. No significance of ESR 325 G→C polymorphism was seen in any of the models under study. Significant differences in genotypic (P = 0...
  10. doi Estrogen receptor (ER) mRNA and ER-related gene expression in breast cancers that are 1% to 10% ER-positive by immunohistochemistry
    Takayuki Iwamoto
    The University of Texas MD Anderson Cancer Center, Houston, TX 77230 1439, USA
    J Clin Oncol 30:729-34. 2012
    We examined borderline estrogen receptor (ER) -positive cancers, defined as having 1% to 10% positivity by immunohistochemistry (IHC), to determine whether they show the same global gene-expression pattern and high ESR1 mRNA expression ..
  11. pmc Unique ERalpha cistromes control cell type-specific gene regulation
    Susan A Krum
    Division of Molecular and Cellular Oncology, Department of Medical Oncology, Dana Farber Cancer Institute, 44 Binney Street, D730, Boston, Massachusetts 02115, USA
    Mol Endocrinol 22:2393-406. 2008
    ..These results support a model for the cell type-specific action of E2 being driven primarily through specific ERalpha occupancy of epigenetically marked cis-regulatory regions of target genes...
  12. ncbi Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1
    Jason S Carroll
    Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, Massachusetts 02115, USA
    Cell 122:33-43. 2005
    ..We have mapped the association of the estrogen receptor (ER) with the complete nonrepetitive sequence of human chromosomes 21 and 22 by combining chromatin ..
  13. doi Coassociation of estrogen receptor and p160 proteins predicts resistance to endocrine treatment; SRC-1 is an independent predictor of breast cancer recurrence
    Aisling M Redmond
    Endocrine Oncology Research Group, Department of Surgery, Royal College of Surgeons in Ireland, Dublin, Ireland
    Clin Cancer Res 15:2098-106. 2009
    This study investigates the role of the p160 coactivators AIB1 and SRC-1 independently, and their interactions with the estrogen receptor, in the development of resistance to endocrine treatments.
  14. pmc Admixture mapping identifies a locus on 6q25 associated with breast cancer risk in US Latinas
    Laura Fejerman
    Department of Medicine, Division of General Internal Medicine, Institute for Human Genetics and Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94158, USA
    Hum Mol Genet 21:1907-17. 2012
    ..The peak of the 6q25 signal includes the estrogen receptor 1 (ESR1) gene and 5' region, a locus previously implicated in breast cancer...
  15. pmc Estrogen receptor-α36 is involved in development of acquired tamoxifen resistance via regulating the growth status switch in breast cancer cells
    Guangliang Li
    Department of Surgical Oncology, The 1st Affiliated Hospital, School of Medicine, Zhejiang University, 79, Qingchun Road, Hangzhou, Zhejiang Province 310003, China
    Mol Oncol 7:611-24. 2013
    ..In this study, we established a TAM resistant cell sub line (MCF-7/TAM) from estrogen receptor-α (ER-α66) positive breast cancer MCF-7 cells by culturing ER-α66-positive MCF-7 cells in medium plus 1 μ..
  16. ncbi The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen
    A K Shiau
    Howard Hughes Medical Institute and the Department of Biochemistry and Biophysics, University of California at San Francisco, 94143 0448, USA
    Cell 95:927-37. 1998
    ..Here we report the crystal structure of the human estrogen receptor alpha (hER alpha) ligand-binding domain (LBD) bound to both the agonist diethylstilbestrol (DES) and a ..
  17. pmc Analysis of the steroid receptor coactivator 1 (SRC1)-CREB binding protein interaction interface and its importance for the function of SRC1
    H M Sheppard
    Department of Biochemistry, University of Leicester, Leicester, LE1 7RH, United Kingdom
    Mol Cell Biol 21:39-50. 2001
    ..We show that in contrast to SRC1, direct binding of CBP to the estrogen receptor is weak, suggesting that SRC1 functions primarily as an adaptor to recruit CBP and p300...
  18. pmc Integration of estrogen and Wnt signaling circuits by the polycomb group protein EZH2 in breast cancer cells
    Bin Shi
    Department of Biochemistry and Molecular Biology, Peking University Health Science Center, 38 Xue Yuan Road, Beijing 100083, China
    Mol Cell Biol 27:5105-19. 2007
    ..We demonstrated that EZH2 physically interacts directly with estrogen receptor alpha and beta-catenin, thus connecting the estrogen and Wnt signaling circuitries, functionally enhances ..
  19. ncbi Positive cross-regulatory loop ties GATA-3 to estrogen receptor alpha expression in breast cancer
    Jerome Eeckhoute
    Division of Molecular and Cellular Oncology, Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Cancer Res 67:6477-83. 2007
    ..factor GATA-3 is required for normal mammary gland development, and its expression is highly correlated with estrogen receptor alpha (ER alpha) in human breast tumors...
  20. doi Endogenous estrogen exposure in relation to distribution of histological type and estrogen receptors in gastric adenocarcinoma
    Evangelos Chandanos
    Unit of Esophageal and Gastric Research, Section of Surgery, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Gastric Cancer 11:168-74. 2008
    ..Estrogen might protect women against gastric adenocarcinoma of the intestinal histological type. We addressed this hypothesis and proposed that gastric estrogen receptors (ERs) are involved...
  21. doi ERα36, a new variant of the ERα is expressed in triple negative breast carcinomas and has a specific transcriptomic signature in breast cancer cell lines
    Vassiliki Pelekanou
    Laboratories of Pathology, University of Crete, School of Medicine, Heraklion, Greece
    Steroids 77:928-34. 2012
    Triple negative breast cancer is deprived of estrogen receptor alpha (ERα), progesterone receptor (PR) and HER-2 protein...
  22. ncbi Human cultured skin fibroblasts express estrogen receptor alpha and beta
    Jozef Haczynski
    Eli Lilly, Medical Department Poland, 01 698 Warszawa, Poland
    Int J Mol Med 10:149-53. 2002
    ..The aim of present study was to confirm the presence of both isoforms of estrogen receptors (ER) in these cells. Experiments were carried out in primary cultures of human skin fibroblasts...
  23. pmc Transcriptional regulation of estrogen receptor-alpha by p53 in human breast cancer cells
    Stephanie Harkey Shirley
    The University of Texas M D Anderson Cancer Center, Science Park Research Division, Smithville, Texas 78957, USA
    Cancer Res 69:3405-14. 2009
    b>Estrogen receptor alpha (ER) and p53 are critical prognostic indicators in breast cancer. Loss of functional p53 is correlated with poor prognosis, ER negativity, and resistance to antiestrogen treatment...
  24. doi Potentially functional polymorphisms in ESR1 and breast cancer risk: a meta-analysis
    Ni Li
    National Office of Cancer Prevention and Control, Cancer Hospital Institute, Chinese Academy of Medical Sciences, Beijing, China
    Breast Cancer Res Treat 121:177-84. 2010
    Estrogen exposure is a central risk factor in the development of breast cancer. Estrogen receptor alpha (coded by ESR1) is the key mediator of estrogen response in mammary tissue...
  25. doi Estrogen receptor α genetic variants and the risk of stroke in a South Indian population from Andhra Pradesh
    Anjana Munshi
    Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Begumpet, Hyderabad 500016, India
    Clin Chim Acta 411:1817-21. 2010
    ..Recent findings have suggested that stroke has a strong genetic component. Evidence suggests that variations in the estrogen receptor α (ESR1) gene may influence stroke risk.
  26. pmc Estrogen receptor alpha expression in ovarian cancer predicts longer overall survival
    Agnieszka Halon
    Department of Pathomorphology, Wroclaw Medical University, Wroclaw, Poland
    Pathol Oncol Res 17:511-8. 2011
    Estrogen as a potential factor of ovarian carcinogenesis, acts via two nuclear receptors, estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ), but the cellular signal pathways involved are not completely clear so far...
  27. ncbi Measuring IGF-1, ER-α and EGFR expression can predict tamoxifen-resistance in ER-positive breast cancer
    Kelvin Chong
    Department of Breast and Endocrine Surgery, St George s Hospital, London, UK
    Anticancer Res 31:23-32. 2011
    ..and downstream signalling of insulin-like growth factor-1 (IGF-1) receptor (IGF-1l), oestrogen receptor-alpha (ERα), epidermal growth factor receptor (EGFR) and HER-2...
  28. ncbi Release of methyl CpG binding proteins and histone deacetylase 1 from the Estrogen receptor alpha (ER) promoter upon reactivation in ER-negative human breast cancer cells
    Dipali Sharma
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, 1650 Orleans Street, Room 409, Baltimore, MD 21231, USA
    Mol Endocrinol 19:1740-51. 2005
    b>Estrogen receptor alpha (ER) is an epigenetically regulated gene...
  29. doi Genetic variation in sex hormone genes influences heel ultrasound parameters in middle-aged and elderly men: results from the European Male Aging Study (EMAS)
    Kate L Limer
    ARC Epidemiology Unit, The University of Manchester, Manchester, United Kingdom
    J Bone Miner Res 24:314-23. 2009
    ....
  30. ncbi Characterization of Brx, a novel Dbl family member that modulates estrogen receptor action
    D Rubino
    Office of the Scientific Director, National Institute of Child Health and Human Development, and DEB, National Institutes of Health, Bethesda, Maryland 20892, USA
    Oncogene 16:2513-26. 1998
    Regulation of gene activation by the estrogen receptor (ER) is complex and involves co-regulatory proteins, oncoproteins (such as Fos and Jun), and phosphorylation signaling pathways...
  31. pmc The aryl hydrocarbon receptor mediates degradation of estrogen receptor alpha through activation of proteasomes
    Mark Wormke
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, TX 77843 4466, USA
    Mol Cell Biol 23:1843-55. 2003
    ..T47D, and MCF-7 human breast cancer cells with TCDD induces proteasome-dependent degradation of endogenous estrogen receptor alpha (ERalpha)...
  32. pmc Hypermethylated 14-3-3-sigma and ESR1 gene promoters in serum as candidate biomarkers for the diagnosis and treatment efficacy of breast cancer metastasis
    Mercedes Zurita
    Radiation Oncology, Hospital Virgen de Nieves, Granada, Spain
    BMC Cancer 10:217. 2010
    ....
  33. pmc Palmitoylation regulates 17β-estradiol-induced estrogen receptor-α degradation and transcriptional activity
    Piergiorgio La Rosa
    Department of Biology, University Roma Tre, I 00146, Rome, Italy
    Mol Endocrinol 26:762-74. 2012
    The estrogen receptor-α (ERα) is a transcription factor that regulates gene expression through the binding to its cognate hormone 17β-estradiol (E2)...
  34. ncbi Association between estrogen receptor alpha gene variation and cardiovascular disease
    Amanda M Shearman
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Mass 02139, USA
    JAMA 290:2263-70. 2003
    ..Relatively little is known, however, about the impact of genetic variation in estrogen receptor alpha (ESR1) on CVD risk.
  35. pmc The G protein-coupled receptor GPR30 inhibits proliferation of estrogen receptor-positive breast cancer cells
    Eric A Ariazi
    Fox Chase Cancer Center Department of Pharmacology, Temple University School of Medicine, Philadelphia, Pennsylvania, USA
    Cancer Res 70:1184-94. 2010
    ..We therefore examined GPR30 in estrogenic activities in ER-positive MCF-7 breast cancer cells using G-1 and diethylstilbestrol (DES), ligands that selectively activate GPR30 ..
  36. pmc PI3-kinase in concert with Src promotes the S-phase entry of oestradiol-stimulated MCF-7 cells
    G Castoria
    Dipartimento di Patologia Generale, Facolta di Medicina e Chirurgia, II Universita di Napoli, Via L De Crecchio, 7, 80138 Napoli, Italy
    EMBO J 20:6050-9. 2001
    ..The ternary complex probably favours hormone activation of Src- and PI3-kinase-dependent pathways, which converge on cell cycle progression...
  37. ncbi Interaction of transcriptional intermediary factor 2 nuclear receptor box peptides with the coactivator binding site of estrogen receptor alpha
    Anette Wärnmark
    Department of Biosciences at Novum, Karolinska Institutet, S 14157 Huddinge, Sweden
    J Biol Chem 277:21862-8. 2002
    ..To better understand the structural basis of motif recognition, we characterized the interaction between estrogen receptor alpha and the NR box regions of the p160 coactivator TIF2...
  38. doi Association of genetic polymorphisms of ER-alpha and the estradiol-synthesizing enzyme genes CYP17 and CYP19 with breast cancer risk in Chinese women
    Lina Zhang
    Departments of Breast Oncology Surgery, Tianjin Medical University Cancer Institute and Hospital, Tianjin, PR China
    Breast Cancer Res Treat 114:327-38. 2009
    Estrogen plays a role in breast cancer development, and genetic polymorphisms in estrogen receptor gene ER-alpha and genes regulating estrogen biosynthesis and metabolisms are associated with the risk of breast cancer in women in western ..
  39. pmc miR-22 inhibits estrogen signaling by directly targeting the estrogen receptor alpha mRNA
    Deo Prakash Pandey
    Departement de Biologie Cellulaire, Universite de Geneve, Sciences III, 30, Quai Ernest Ansermet, CH 1211 Geneva 4, Switzerland
    Mol Cell Biol 29:3783-90. 2009
    b>Estrogen receptor alpha (ER alpha) is a ligand-regulated transcription factor with a broad range of physiological functions and one of the most important classifiers in breast cancer...
  40. ncbi The PGC-1-related protein PERC is a selective coactivator of estrogen receptor alpha
    Dieter Kressler
    Division of Biochemistry, Biozentrum of the University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    J Biol Chem 277:13918-25. 2002
    ..It enhances potently the activity of estrogen receptor (ER) alpha, while having only small effects on other receptors...
  41. doi Estrogen receptor regulation of carbonic anhydrase XII through a distal enhancer in breast cancer
    Daniel H Barnett
    Department of Cell and Developmental Biology, College of Medicine, University of Illinois at Urbana Champaign, Urbana, IL 61801 3704, USA
    Cancer Res 68:3505-15. 2008
    ..responsible for acidification of the microenvironment of cancer cells, is highly correlated with estrogen receptor alpha (ER alpha) in human breast tumors...
  42. pmc PES1 promotes breast cancer by differentially regulating ERα and ERβ
    Long Cheng
    Department of Medical Molecular Biology, Beijing Institute of Biotechnology, Beijing, People s Republic of China
    J Clin Invest 122:2857-70. 2012
    The initiation of breast cancer is associated with increased expression of tumor-promoting estrogen receptor α (ERα) protein and decreased expression of tumor-suppressive ERβ protein...
  43. doi Homeobox A7 stimulates breast cancer cell proliferation by up-regulating estrogen receptor-alpha
    Yu Zhang
    Department of Reproductive Endocrinology, Women s Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China Department of Obstetrics and Gynaecology, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada
    Biochem Biophys Res Commun 440:652-7. 2013
    ..Estradiol (E2) and its nuclear receptors, estrogen receptor (ER)-alpha and ER-beta, are known to play critical roles in the regulation of breast cancer cell growth...
  44. doi Histone acetyltransferase Hbo1 destabilizes estrogen receptor α by ubiquitination and modulates proliferation of breast cancers
    Masayoshi Iizuka
    Department of Biochemistry, Teikyo University School of Medicine, Tokyo, Japan
    Cancer Sci 104:1647-55. 2013
    The estrogen receptor (ER) is a key molecule for growth of breast cancers. It has been a successful target for treatment of breast cancers...
  45. pmc Four miRNAs associated with aggressiveness of lymph node-negative, estrogen receptor-positive human breast cancer
    John A Foekens
    Department of Medical Oncology, Erasmus Medical Center Rotterdam, Josephine Nefkens Institute, 3000 CA Rotterdam, The Netherlands
    Proc Natl Acad Sci U S A 105:13021-6. 2008
    In this study, we quantified 249 mature micro-RNA (miRNA) transcripts in estrogen receptor-positive (ER(+)) primary breast tumors of patients with lymph node-negative (LNN) disease to identify miRNAs associated with metastatic capability...
  46. doi Association of polymorphisms in the estrogen receptors alpha, and beta (ESR1, ESR2) with the occurrence of male infertility and semen parameters
    Mohammad Reza Safarinejad
    J Steroid Biochem Mol Biol 122:193-203. 2010
    ..Polymorphisms of the estrogen receptor (ER) genes, have been implicated in male infertility, however, comprehensive data are lacking...
  47. pmc A positive cross-regulation of HER2 and ER-α36 controls ALDH1 positive breast cancer cells
    Lianguo Kang
    Department of Medical Microbiology and Immunology, Creighton University Medical School, 2500 California Plaza, Omaha, NE 68178, USA
    J Steroid Biochem Mol Biol 127:262-8. 2011
    ..of breast cancer stem/progenitor cells has not been fully established, mainly because expression and function of ER-α in breast cancer stem cells remains controversial...
  48. pmc P21-activated kinase-1 phosphorylates and transactivates estrogen receptor-alpha and promotes hyperplasia in mammary epithelium
    Rui An Wang
    Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
    EMBO J 21:5437-47. 2002
    ..of Pak1 kinase activity by a dominant-negative fragment or by short interference RNA markedly reduced the estrogen receptor-alpha (ER) transactivation functions...
  49. ncbi Mechanisms of naringenin-induced apoptotic cascade in cancer cells: involvement of estrogen receptor alpha and beta signalling
    Pierangela Totta
    Department of Biology, University Roma Tre, Viale G Marconi, 446, I 00146 Rome, Italy
    IUBMB Life 56:491-9. 2004
    ..transduction pathway committed to the generation of an apoptotic cascade in the presence of one of the two estrogen receptor (ER) isoforms (i.e., ERalpha or ERbeta)...
  50. ncbi Regulation of GREB1 transcription by estrogen receptor alpha through a multipartite enhancer spread over 20 kb of upstream flanking sequences
    Julie Deschênes
    Institute for Research in Immunology and Cancer, Department of Biochemistry, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada
    J Biol Chem 282:17335-9. 2007
    ..Larios, J. M., and Lippman, M. E. (2005) Breast Cancer Res. Treat 92, 141-149), is mediated by binding of estrogen receptor alpha (ERalpha) to three consensus EREs spread over approximately 20 kb of upstream flanking sequences...
  51. ncbi Growth factor signaling pathways modulate BRCA1 repression of estrogen receptor-alpha activity
    Yongxian Ma
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, D C 20057 1469, USA
    Mol Endocrinol 21:1905-23. 2007
    ..Previously, we demonstrated a functional interaction between the BRCA1 and estrogen receptor-alpha (ER-alpha) proteins that causes inhibition of ER-alpha signaling...
  52. pmc p53, a target of estrogen receptor (ER) α, modulates DNA damage-induced growth suppression in ER-positive breast cancer cells
    Crystal E Berger
    Comparative Oncology Laboratory, University of California, Davis, CA 95616, USA
    J Biol Chem 287:30117-27. 2012
    ..70% of all breast cancer cases are estrogen receptor (ER)-positive and express ERα...
  53. doi Estrogen receptor-α variant, ER-α36, is involved in tamoxifen resistance and estrogen hypersensitivity
    Xiantian Zhang
    Department of Medical Microbiology, Creighton University Medical School, Criss III, Room 352, 2500 California Plaza, Omaha, Nebraska 68178, USA
    Endocrinology 154:1990-8. 2013
    Antiestrogens such as tamoxifen (TAM) provided a successful treatment for estrogen receptor (ER)-positive breast cancer for the past four decades. However, most breast tumors are eventually resistant to TAM therapy...
  54. pmc AIB1 cooperates with ERα to promote epithelial mesenchymal transition in breast cancer through SNAI1 activation
    Miao Wang
    School of Life Science and Biotechnology, Dalian University of Technology, Dalian, China
    PLoS ONE 8:e65556. 2013
    ..the action of the transcription factor SNAI1, and demonstrated that such interaction required the participation of ERα and the presence of ERα-binding site on SNAI1 promoter...
  55. pmc Ligand-independent activation of oestrogen receptor alpha by caveolin-1
    A Schlegel
    Department of Molecular Pharmacology, The Albert Einstein Cancer Centre, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Biochem J 359:203-10. 2001
    ..caveolin-1 in the human mammary adenocarcinoma cell line MCF-7 causes ligand-independent concentration of oestrogen receptor alpha (ERalpha) in the nucleus, and potentiates ligand-independent and ligand-dependent transcription from an ..
  56. ncbi Association of polymorphisms of the estrogen receptor alpha gene with bone mineral density and fracture risk in women: a meta-analysis
    John P A Ioannidis
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Greece
    J Bone Miner Res 17:2048-60. 2002
    ..We evaluated the effect of the XbaI and PvuII polymorphisms of the estrogen receptor a to BMD and fracture risk in a meta-analysis, including published data and additional information from ..
  57. ncbi Ligand-independent coactivation of ERalpha AF-1 by steroid receptor RNA activator (SRA) via MAPK activation
    Geneviève Deblois
    Molecular Oncology Group, McGill University Health Center, room H5 21, 687 Pine Avenue West, Montreal, Quebec, Canada H3A 1A1
    J Steroid Biochem Mol Biol 85:123-31. 2003
    ..In this work, we describe the effect of SRA on the activity of the two estrogen receptor (ER) isoforms, ERalpha and ERbeta...
  58. ncbi ICI182,780 induces p21Waf1 gene transcription through releasing histone deacetylase 1 and estrogen receptor alpha from Sp1 sites to induce cell cycle arrest in MCF-7 breast cancer cell line
    Rana Varshochi
    Cancer Research UK Laboratories and Section of Cancer Cell Biology, Department of Cancer Medicine, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 ONN, United Kingdom
    J Biol Chem 280:3185-96. 2005
    ..DNA "pull-down," and chromatin immunoprecipitation experiments together showed that in cycling cells, estrogen receptor alpha and histone deacetylase 1 (HDAC1) are recruited to the proximal Sp1 sites of the promoter to repress ..
  59. ncbi Microsatellite profile in hormonal receptor genes associated with breast cancer
    C Iobagiu
    Immunology Laboratory, University Hospital of St Etienne, St Etienne cedex 2, France
    Breast Cancer Res Treat 95:153-9. 2006
    Given that breast cancer is depending on multiple hormonal influences, the nuclear receptors, estrogen receptor alpha, estrogen receptor beta and androgen receptor, are candidates for cancer susceptibility markers...
  60. doi Gender-specific effect of estrogen receptor-1 gene polymorphisms in coronary artery disease and its angiographic severity in Chinese population
    Haiying Xu
    Department of Cardiology, Hangzhou First Municipal Hospital and Hangzhou Hospital, Nanjing Medical University, Hangzhou 310006, China
    Clin Chim Acta 395:130-3. 2008
    The role of common polymorphisms of the estrogen receptor-1 in coronary artery disease (CAD) and it association with angiographic severity reminds conflicting in sexes and different races.
  61. ncbi Estrogen receptor 1 gene polymorphisms in premenopausal women: interaction between genotype and smoking on lipid levels
    S Almeida
    Departamento de Genetica, Instituto de Biociencias, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil
    Braz J Med Biol Res 41:872-6. 2008
    ..We investigated the association between the four common single nucleotide polymorphisms in the estrogen receptor 1 (ESR1) gene locus, -1989T>G, +261G>C, IVS1-397T>C and IVS1-351A>G, and lipid and lipoprotein ..
  62. doi S6 kinase 1 regulates estrogen receptor alpha in control of breast cancer cell proliferation
    Rachel L Yamnik
    Department of Biology, Stern College for Women of Yeshiva University, New York, New York 10016, USA
    J Biol Chem 284:6361-9. 2009
    ..We investigate the molecular mechanism behind this observation to show that S6K1 regulates estrogen receptor alpha (ERalpha) by phosphorylating it on serine 167, leading to transcriptional activation of ERalpha...
  63. ncbi Hemin inhibits cyclin D1 and IGF-1 expression via STAT5b under hypoxia in ERalpha-negative MDA-MB 231 breast cancer cells
    Eun Joung Lim
    Department of Pathology, School of Medicine, and Institute of Biomedical Science and Technology, Konkuk University, Seoul 143 701, Korea
    Int J Oncol 36:1243-51. 2010
    ..These findings are valuable toward understanding the role of hemin-induced inhibition of cyclin D1 and IGF-1 expression under hypoxia in invasive and metastatic breast cancer...
  64. pmc Estrogen receptor α36 mediates a bone-sparing effect of 17β-estrodiol in postmenopausal women
    Hui Xie
    Institute of Endocrinology and Metabolism, Second Xiangya Hospital of Central South University, Changsha, Hunan, People s Republic of China
    J Bone Miner Res 26:156-68. 2011
    Recently, a membrane-based estrogen receptor (ER), ER-α36, was identified and cloned that transduces membrane-initiated estrogen signaling such as activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase (..
  65. pmc Selected estrogen receptor 1 and androgen receptor gene polymorphisms in relation to risk of breast cancer and fibrocystic breast conditions among Chinese women
    Lori C Sakoda
    Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Cancer Epidemiol 35:48-55. 2011
    ..Polymorphisms in sex hormone receptor-encoding genes may alter the activity of sex hormone receptors and thereby affect susceptibility to breast cancer and related outcomes...
  66. pmc Transducin-like enhancer protein 1 mediates estrogen receptor binding and transcriptional activity in breast cancer cells
    Kelly A Holmes
    Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, United Kingdom
    Proc Natl Acad Sci U S A 109:2748-53. 2012
    b>Estrogen receptor (ER) binds to distal enhancers within the genome and requires additional factors, such as the Forkhead protein FoxA1, for mediating chromatin interactions...
  67. pmc Regulation of estrogen receptor α N-terminus conformation and function by peptidyl prolyl isomerase Pin1
    Prashant Rajbhandari
    Department of Oncology and UW Carbone Comprehensive Cancer Center, University of Wisconsin Madison, Madison, Wisconsin, USA
    Mol Cell Biol 32:445-57. 2012
    b>Estrogen receptor alpha (ERα), a key driver of growth in the majority of breast cancers, contains an unstructured transactivation domain (AF1) in its N terminus that is a convergence point for growth factor and hormonal activation...
  68. doi Evaluation of a hormone receptor-positive ovarian carcinoma subtype with a favourable prognosis by determination of progesterone receptor and oestrogen receptor 1 mRNA expression in formalin-fixed paraffin-embedded tissue
    Bruno V Sinn
    Institute of Pathology, Charite Universitatsmedizin Berlin, Germany
    Histopathology 59:918-27. 2011
    ..The aim of this study was to examine the prognostic role of progesterone receptor (PR) protein and mRNA expression...
  69. pmc BRCA1 mediates ligand-independent transcriptional repression of the estrogen receptor
    L Zheng
    Department of Molecular Medicine and Institute of Biotechnology, University of Texas Health Science Center, San Antonio 78245, USA
    Proc Natl Acad Sci U S A 98:9587-92. 2001
    ..Here we show that BRCA1 mediates ligand-independent transcriptional repression of the estrogen receptor alpha (ERalpha), a principal determinant of the growth, differentiation, and normal functional status of ..
  70. ncbi The activation function-1 domain of estrogen receptor alpha in uterine stromal cells is required for mouse but not human uterine epithelial response to estrogen
    Takeshi Kurita
    Department of Anatomy, University of California, San Francisco, CA 94143 0452, USA
    Differentiation 73:313-22. 2005
    The activation function-1 (AF-1) domain of the estrogen receptor alpha (ERalpha) in stromal cells has been shown to be required for epithelial responses to estrogen in the mouse uterus...
  71. pmc No role for estrogen receptor 1 gene intron 1 Pvu II and exon 4 C325G polymorphisms in migraine susceptibility
    Natalie J Colson
    Genomics Research Centre, School of Health Science, Griffith University Gold Coast, PMB 50, Gold Coast Mail Centre, Queensland, 9726, Australia
    BMC Med Genet 7:12. 2006
    We have previously reported an association between the estrogen receptor 1 (ESR1) gene exon 8 G594A polymorphism and migraine susceptibility in two independent Australian cohorts...
  72. ncbi Association of the estrogen receptor-alpha gene with the metabolic syndrome and its component traits in African-American families: the Insulin Resistance Atherosclerosis Family Study
    Carla J Gallagher
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Diabetes 56:2135-41. 2007
    We previously detected an association between a region of the estrogen receptor-alpha (ESR1) gene and type 2 diabetes in an African-American case-control study; thus, we investigated this region for associations with the metabolic ..
  73. ncbi Allelic estrogen receptor 1 (ESR1) gene variants predict the outcome of ovarian stimulation in in vitro fertilization
    Signe Altmäe
    Department of Biotechnology, Institute of Molecular and Cell Biology, Estonian Genome Project, University of Tartu, Estonia, and Department of Clinical Science, Intervention and Technology, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Mol Hum Reprod 13:521-6. 2007
    ..We determined the associations between genetic variations in estrogen receptor ESR1 and ESR2 genes and etiology of female infertility, and analysed the influence of these variations on ..
  74. pmc ERalpha suppresses slug expression directly by transcriptional repression
    Yin Ye
    Department of Pathology, The Ohio State University College of Medicine, 129 Hamilton Hall, 1645 Neil Avenue, Columbus, OH 43210, USA
    Biochem J 416:179-87. 2008
    Two of the most common signalling pathways in breast cancer are the ER (oestrogen receptor) ligand activation pathway and the E-cadherin snai1 slug EMT (epithelial-mesenchymal transition) pathway...
  75. pmc A novel variant of ER-alpha, ER-alpha36 mediates testosterone-stimulated ERK and Akt activation in endometrial cancer Hec1A cells
    Sheng Li Lin
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    Reprod Biol Endocrinol 7:102. 2009
    ..Recently, we identified and cloned a variant of estrogen receptor (ER) alpha, ER-alpha36...
  76. pmc Notch-1 activates estrogen receptor-alpha-dependent transcription via IKKalpha in breast cancer cells
    L Hao
    Breast Cancer Program, Cardinal Bernardin Cancer Center, Loyola University Chicago, Maywood, IL, USA
    Oncogene 29:201-13. 2010
    Approximately 80% of breast cancers express the estrogen receptor-alpha (ERalpha) and are treated with anti-estrogens. Resistance to these agents is a major cause of mortality...
  77. pmc Selective association of peroxiredoxin 1 with genomic DNA and COX-2 upstream promoter elements in estrogen receptor negative breast cancer cells
    Xuemei Wang
    Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Manitoba R3E0V9, Canada
    Mol Biol Cell 21:2987-95. 2010
    ..cancer cell lines, we identified peroxiredoxin 1 (PRDX1) as a protein preferentially cross-linked to DNA in estrogen receptor negative (ER-) MDA-MB-231 but not in estrogen receptor positive (ER+) MCF7 breast cancer cells...
  78. ncbi Estrogen and progesterone receptor subtype expression in normal and malignant ovarian epithelial cell cultures
    Andrew J Li
    Department of Obstetrics and Gynecology, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Am J Obstet Gynecol 189:22-7. 2003
    ..Epidemiologic data suggest that the malignant transformation of ovarian epithelium may be linked to altered steroid hormone homeostasis...
  79. pmc The histone modifications governing TFF1 transcription mediated by estrogen receptor
    Yanyan Li
    Key Laboratory of Carcinogenesis and Translational Research Ministry of Education, Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing 100191, China
    J Biol Chem 286:13925-36. 2011
    ..Here we describe spatial and temporal analyses of the histone modifications that are introduced during estrogen receptor α (ERα)-activated transcription...
  80. ncbi Polymorphisms of the androgen receptor gene and the estrogen receptor beta gene are associated with androgen levels in women
    L Westberg
    Department of Pharmacology, Goteborg University, SE 405 30 Goteborg, Sweden
    J Clin Endocrinol Metab 86:2562-8. 2001
    To elucidate the possible role of genetic variation in androgen receptor (AR), estrogen receptor alpha (ER alpha), and ER beta on serum androgen levels in premenopausal women, the CAG repeat polymorphism of the AR gene, the TA repeat ..
  81. ncbi p130Cas interacts with estrogen receptor alpha and modulates non-genomic estrogen signaling in breast cancer cells
    Sara Cabodi
    Dipartimento di Genetica, Biologia e Biochimica, Universita di Torino, Via Santena 5 bis, 10126 Turin, Italy
    J Cell Sci 117:1603-11. 2004
    ..breast carcinoma T47D cells, upon estrogen treatment, p130Cas rapidly and transiently associates with the estrogen receptor alpha in a multi-molecular complex containing the c-Src kinase and the p85 subunit of PI 3-kinase...
  82. ncbi Common estrogen receptor polymorphism augments effects of hormone replacement therapy on E-selectin but not C-reactive protein
    David M Herrington
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1045, USA
    Circulation 105:1879-82. 2002
    The estrogen receptor-alpha (ER-alpha) IVS1-401 polymorphism identifies a group of women (approximately 20%) who have augmented effects of hormone replacement therapy (HRT) on levels of HDL cholesterol...
  83. ncbi Ligand-dependent nuclear receptor corepressor LCoR functions by histone deacetylase-dependent and -independent mechanisms
    Isabelle Fernandes
    Department of Physiology, McGill University, Montreal, Quebec, Canada H3G 1Y6
    Mol Cell 11:139-50. 2003
    ..LCoR binding to estrogen receptor alpha depends in part on residues in the coactivator binding pocket distinct from those bound by TIF-2...
  84. ncbi Phosphorylation of ERalpha at serine 118 in primary breast cancer and in tamoxifen-resistant tumours is indicative of a complex role for ERalpha phosphorylation in breast cancer progression
    N Sarwar
    Department of Oncology, Imperial College London, Hammersmith Hospital Campus, UK
    Endocr Relat Cancer 13:851-61. 2006
    ....
  85. pmc Signal transducer and activator of transcription 5b, c-Src, and epidermal growth factor receptor signaling play integral roles in estrogen-stimulated proliferation of estrogen receptor-positive breast cancer cells
    Emily M Fox
    Department of Pharmacology, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    Mol Endocrinol 22:1781-96. 2008
    17beta-Estradiol (E2) acts through the estrogen receptor alpha (ERalpha) to stimulate breast cancer proliferation...
  86. pmc Genomic antagonism between retinoic acid and estrogen signaling in breast cancer
    Sujun Hua
    Institute for Genomics and Systems Biology and Department of Human Genetics, The University of Chicago, 920 East 58th Street, Chicago, IL 60637, USA
    Cell 137:1259-71. 2009
    ..We found that RAR binding throughout the genome is highly coincident with estrogen receptor alpha (ERalpha) binding, resulting in a widespread crosstalk of RA and estrogen signaling to ..
  87. pmc BRCA1 regulates acetylation and ubiquitination of estrogen receptor-alpha
    Yongxian Ma
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057 1469, USA
    Mol Endocrinol 24:76-90. 2010
    ..The (300)RXKK and (266)KXK motifs have been identified previously as sites for acetylation of the estrogen receptor-alpha (ER-alpha), and (302)K was also found to be a site for BRCA1-mediated mono-ubiquitination of ER-alpha ..
  88. doi Estrogen receptor regulates E2F1 expression to mediate tamoxifen resistance
    Maggie C Louie
    Department of Natural Sciences and Mathematics, Dominican University of California, San Rafael, CA 94901, USA
    Mol Cancer Res 8:343-52. 2010
    ..Faslodex or ICI 182, 780 (ICI)-mediated degradation of estrogen receptor (ER) reduced the proliferation of these cells, as well as the level of E2F1 expression in tamoxifen-..
  89. pmc Cellular reprogramming by the conjoint action of ERα, FOXA1, and GATA3 to a ligand-inducible growth state
    Say Li Kong
    Cancer Biology and Pharmacology 2, Genome Institute of Singapore, Singapore
    Mol Syst Biol 7:526. 2011
    Despite the role of the estrogen receptor α (ERα) pathway as a key growth driver for breast cells, the phenotypic consequence of exogenous introduction of ERα into ERα-negative cells paradoxically has been growth inhibition...
  90. ncbi Connections and regulation of the human estrogen receptor
    Donald P McDonnell
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Box 3813, Durham, NC 27710, USA
    Science 296:1642-4. 2002
    ..Thus, although the estrogen receptor is required for a cell to respond to an estrogenic stimulus, the nature and extent of that response are ..
  91. ncbi Estrogen receptor-alpha regulates the degradation of insulin receptor substrates 1 and 2 in breast cancer cells
    Catia Morelli
    Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Oncogene 22:4007-16. 2003
    ..Here we studied whether the expression of estrogen receptor (ER)-alpha affects IRS molecules post-transcriptionally...
  92. ncbi Expression of estrogen receptor alpha, retinoic acid receptor alpha and cellular retinoic acid binding protein II genes is coordinately regulated in human breast cancer cells
    Min Lu
    Division of Hematology Oncology, Department of Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029 6574, USA
    Oncogene 24:4362-9. 2005
    Human breast cancer cell lines expressing the estrogen receptor alpha (ERalpha), all-trans-retinoic acid (ATRA) receptor alpha (RARalpha) and cellular retinoic acid binding protein II (CRABPII) genes are sensitive to ATRA-mediated growth ..
  93. pmc Phosphorylation at serines 104 and 106 by Erk1/2 MAPK is important for estrogen receptor-alpha activity
    Ross S Thomas
    Cancer Research UK Laboratories, Department of Oncology, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
    J Mol Endocrinol 40:173-84. 2008
    Phosphorylation of estrogen receptor-alpha (ERalpha) at specific residues in transcription activation function 1 (AF-1) can stimulate ERalpha activity in a ligand-independent manner...
  94. doi Wilms' tumor 1 suppressor gene mediates antiestrogen resistance via down-regulation of estrogen receptor-alpha expression in breast cancer cells
    Youqi Han
    Princess Margaret Hospital Ontario Cancer Institute, University Health Network, Toronto, Ontario, Canada M5G 2M9
    Mol Cancer Res 6:1347-55. 2008
    ..The loss of estrogen receptor (ER) expression is the most common mechanism for de novo antiestrogen resistance...
  95. doi Clinical significance of estrogen receptor phosphorylation
    Leigh C Murphy
    Department of Biochemistry and Medical Genetics, Faculty of Medicine Manitoba Institute of Cell Biology, University of Manitoba, 675 McDermot Avenue, Winnipeg, Manitoba, Canada
    Endocr Relat Cancer 18:R1-14. 2011
    Multiple sites of phosphorylation on human estrogen receptor α (ERα) have been identified by a variety of methodologies...
  96. pmc The cholesterol metabolite 25-hydroxycholesterol activates estrogen receptor α-mediated signaling in cancer cells and in cardiomyocytes
    Rosamaria Lappano
    Department of Pharmaco Biology, University of Calabria, Rende, Italy
    PLoS ONE 6:e16631. 2011
    ..In addition, the levels of oxysterols, including 25 HC, have been found to be elevated in hypercholesterolemic serum...
  97. ncbi Multiple mechanisms induce transcriptional silencing of a subset of genes, including oestrogen receptor alpha, in response to deacetylase inhibition by valproic acid and trichostatin A
    George Reid
    European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Oncogene 24:4894-907. 2005
    ..Furthermore, we demonstrate that, in the presence of VPA, local DNA methylation, deacetylation and demethylation of activated histones and recruitment of inhibitory complexes occurs on the pS2 promoter...
  98. pmc Functional regulation of oestrogen receptor pathway by the dynein light chain 1
    Suresh K Rayala
    Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
    EMBO Rep 6:538-44. 2005
    ..However, the role of DLC1 in the action of the oestrogen receptor (ER) remains unknown. Here, we found that oestrogen induces the transcription and expression of DLC1...
  99. pmc From the Cover: Location analysis of estrogen receptor alpha target promoters reveals that FOXA1 defines a domain of the estrogen response
    Josee Laganiere
    Molecular Oncology Group, Department of Medicine, McGill University Health Centre, Montreal, QC, Canada H3A 1A1
    Proc Natl Acad Sci U S A 102:11651-6. 2005
    ..We used a genome-wide analysis of promoter occupancy by the estrogen receptor alpha (ERalpha) in MCF-7 cells to investigate the molecular mechanisms underlying the action of 17beta-..
  100. pmc OPG and RANK polymorphisms are both associated with cortical bone mineral density: findings from a metaanalysis of the Avon longitudinal study of parents and children and gothenburg osteoporosis and obesity determinants cohorts
    L Paternoster
    Medical Research Council Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, United Kingdom
    J Clin Endocrinol Metab 95:3940-8. 2010
    ..Several single-nucleotide polymorphisms (SNPs) have been reliably associated with areal bone mineral density (aBMD) in genome-wide association studies of mostly older subjects...
  101. doi Association between the polymorphism of estrogen receptor α and coronary artery disease in a Chinese population
    Cheng Shen
    Department of Cardiovascular Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, China
    Eur J Intern Med 23:175-8. 2012
    The role of estrogen receptor α (ERα) polymorphism in coronary artery disease (CAD) was investigated previously in several populations. There are few data on relation between ERa polymorphism and CAD in Chinese population...

Research Grants72

  1. Regulation of dendritic cells by estrogen receptors during influenza infection
    Susan Kovats; Fiscal Year: 2012
    ..This project will determine how one such physiological factor, estrogen receptor alpha (ER1) signaling, regulates the innate immune response to influenza virus infection in mice...
  2. ESTROGEN MODULATION OF HUMAN NOCICEPTORS
    Kenneth M Hargreaves; Fiscal Year: 2012
    ..Our preliminary studies identified estrogen receptor 1 (ER1) and ER1 in both human trigeminal ganglia neurons and in peripheral neurons in surgical biopsies, and ..
  3. Mechanism of Age-Related Change in Estrogen Receptor Beta Expression in Rat Brain
    JENNE MITCHELL WESTBERRY; Fiscal Year: 2012
    ..reason for this observation is that the timing of hormone replacement is critical and thus changes in estrogen receptor expression in the brain may over-ride any potential hormonal intervention...
  4. Michael J Soares; Fiscal Year: 2014
    ..Estradiol binds and signals through estrogen receptor alpha (ESR1) and estrogen receptor beta (ESR2), while progesterone signals through the progesterone receptor ..
  5. Effects of Estradiol &Phytoestrogens on Stress Responsivity
    Pauline M Maki; Fiscal Year: 2013
    ..during the menopausal transition, and indirect data suggest a potential role for estrogen, particularly estrogen receptor beta, in mediating anxiety...
  6. Regulation of miRNA in breast cancer
    Carolyn M Klinge; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The selective estrogen receptor modulator (SERM) tamoxifen (TAM) is the most widely used endocrine therapy for the treatment and prevention of estrogen receptor alpha (ER1) positive breast cancer...
  7. Regulation of miRNA expression in breast cancer cells
    CAROLYN KLINGE; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): The selective estrogen receptor modulator (SERM) tamoxifen (TAM) is the most widely used endocrine therapy for the treatment and prevention of estrogen receptor alpha (ERalpha) positive breast cancer...
  8. Role of Estrogen Receptors in Lupus-Modulators of the Inflammatory Response
    Gary S Gilkeson; Fiscal Year: 2013
    ..Estrogen acts primarily via its receptors, estrogen receptor alpha and beta (ER[unreadable]/ER[unreadable])...
  9. TNRF1 Signaling Resistance in Ischemic Human Female Myocardium
    Daniel R Meldrum; Fiscal Year: 2010
    ..preliminary data suggests that TNFR1 signaling resistance occurs in female myocardium which may be due to estrogen receptor mediated upregulation of SOCS protein production...
  10. Effects of Bisphenol A Exposure on Genomic Imprinting in the Mouse
    Martha Susiarjo; Fiscal Year: 2012
    ..question of whether estrogen receptors mediate BPA-induced effects, mice lacking functional genes for the estrogen receptor alpha and beta will be exposed to BPA and the effects on epigenetic gene regulation will be assessed...
  11. ETHAN SAMUEL BURSTEIN; Fiscal Year: 2014
    ..Acadia Pharmaceuticals has discovered highly selective estrogen receptor beta (ER[unreadable])-agonists that are highly efficacious in animal models of neuropathic pain...
  12. Estrogen and Memory: Genetic Variation and Neuroimaging
    Susan K Conroy; Fiscal Year: 2013
    ..disease (AD), we will assess the contribution of genetic variation in the estrogen pathway genes ESR1 (estrogen receptor 1), ESR2 (estrogen receptor 2), and CYP19A1 (aromatase), to alterations in brain morphology, including ..
  13. Interferon and Raloxifene Effects on Cancer Cells
    CHERYL ROSENFELD; Fiscal Year: 2007
    ..Dennis Lubahn on abnormalities in the ovaries and reproductive tract of mice null for the estrogen receptor-alpha gene (ERaKO mouse)...
  14. GENE ACTIVATION BY ANTIESTROGENS USED IN CANCER THERAPY
    Peter Kushner; Fiscal Year: 2007
    Our long term objective is to understand the biochemical mechanisms and physiological significance of estrogen receptor alpha (ERalpha) and estrogen receptor beta (ERbeta) activation of gene expression at target genes with AP-1 or CRE ..
  15. Comparative Genomics Study of Foxa/ER Targets in Liver Cancer and Breast Cancer
    Zhaoyu Li; Fiscal Year: 2012
    ..In vitro studies show that estrogen signaling through estrogen receptor alpha (ER[unreadable]) in promoting the growth of breast cancer cells relies on forkhead box protein A (Foxa)..
  16. Zhaoyu Li; Fiscal Year: 2015
    ..In vitro studies show that estrogen signaling through estrogen receptor alpha (ER[unreadable]) in promoting the growth of breast cancer cells relies on forkhead box protein A (Foxa)..
  17. Estrogen Receptor 1 Gene, Adiposity, and Breast Cancer
    Heather M Ochs-Balcom; Fiscal Year: 2013
    ..Since the estrogen receptor plays a key role in mediating the biological impact of estrogen, inherited variants in the estrogen receptor-..
  18. Prevalence of CD24 epigenetic silencing in breast tumors and ERalpha status
    Benny Abraham Kaipparettu; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): 1. Abstract Two-thirds of breast cancers express estrogen receptor alpha (ER1) and rely upon ER1 signaling for their growth...
  19. Linda A Schuler; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): 75% of all breast tumors in women express estrogen receptor alpha (ER?+)...
  20. Interactions of PRL, Estrogen, and TFFa in Mammary Cancer
    Lisa M Arendt; Fiscal Year: 2010
    ..These mice develop mammary adenocarcinomas that are estrogen receptor alpha positive and negative, similar to human disease...
  21. Interleukin-6/Stat3 regulation of the Estrogen Receptor Alpha in Breast Cancer
    JENNIFER EBELE NNOLI; Fiscal Year: 2013
    ..Recent studies have linked IL-6 as a potent growth factor in estrogen receptor (ER) positive breast cancers...
  22. Steven M Kawut; Fiscal Year: 2016
    ..We showed that variation in genes linked to estrogen signaling (aromatase and estrogen receptor alpha (ESR1)) and higher estradiol levels significantly increased the risk of PPHTN in patients with ..
  23. Biological Mechanisms of Arterial Stiffening With Age and Estrogen Deficiency
    KERRIE MOREAU; Fiscal Year: 2010
    ..g., NADPH) and antioxidant (e.g., glutathione peroxidase) enzymes, vasoconstrictors (endothelin- 1), and estrogen receptor alpha (ERalpha)...
  24. Fliz1 regulation of GATA-3 in breast cancer
    Janice E Knepper; Fiscal Year: 2013
    ..GATA-3 expression is high in normal human breast epithelium and in estrogen receptor positive tumors, as GATA-3 directly regulates expression of estrogen receptor alpha (ER?)...
  25. Jill M Daniel; Fiscal Year: 2016
    ..The central hypothesis to be tested is that lasting changes in levels of estrogen receptor alpha (ER[unreadable]) and in the insulin-like growth factor-1 (IGF-1) system in the hippocampus resulting ..
  26. Significance of PELP1 in Breast Cancer Progression
    VALERIE ANN CORTEZ; Fiscal Year: 2013
    ..Steroid hormone estrogen, influence development and progression of breast cancer via interactions with estrogen receptor-alpha (ERalpha). At diagnosis, approximately 70% of breast tumors express ERalpha...
  27. Perinatal exposure to environmental estrogens and asthma pathogenesis
    Terumi Midoro Horiuti; Fiscal Year: 2010
    ..potentiate the synthesis and release of allergic mediators from mast cells, through a membrane form of estrogen receptor alpha...
  28. Nuclear Architecture, NcRNAs and Epigenetics in Transcriptional Regulation by ER
    Chunru Lin; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Estradiol, which acts through the Estrogen Receptor alpha (ER[unreadable]), is essential for the development and homeostasis of female reproductive function, exerting critical control of many ..
  29. Role of Estrogen Receptor alpha-p53 Interaction in Resistance to Tamoxifen Therap
    Swati Kulkarni; Fiscal Year: 2010
    ..anti hormonal drug tamoxifen is approved for the treatment of women with early and advanced and early stage estrogen receptor (ER)-positive breast cancer...
  30. Chunru Lin; Fiscal Year: 2015
    Project Summary Estradiol, which acts through the Estrogen Receptor alpha (ER[unreadable]), is essential for the development and homeostasis of female reproductive function, exerting critical control of many transcriptional programs, ..
  31. Development of Breast Cancer Risk Model Based on Estrogen Metabolomics
    Richard J Santen; Fiscal Year: 2013
    ..We propose an integrative hypothesis regarding the carcinogenic process which involves both estrogen receptor alpha (ER[unreadable]) dependent as well as ER[unreadable] independent actions...
  32. Epigenetic Molecular Mechanisms and Reproductive Transitions
    Deena M Walker; Fiscal Year: 2011
    ..The focus will be the estrogen receptor alpha (ERa) and kisspeptin, chosen because these hypothalamic genes are expressed in a sexually dimorphic ..
  33. TROY ADAM ROEPKE; Fiscal Year: 2014
    ..through an estradiol-responsive membrane GPCR (mER) and control of gene expression in arcuate neurons through both ERa- and mER-mediated mechanisms...
  34. CLARE ANN FLANNERY; Fiscal Year: 2016
    ..She hypothesizes that insulin induces a post-translational modification of the estrogen receptor, resulting in a change in gene transcription...
  35. Martha Susiarjo; Fiscal Year: 2014
    ..The candidate will include mice lacking the functional genes for estrogen receptor alpha and beta as BPA is an estrogen and the project aims to investigate if these receptors mediate BPA ..
  36. Estrogen signaling transgenic mouse models
    Richard R Behringer; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Estrogen receptor alpha (ERa) and beta (ER[unreadable]) are members of the nuclear receptor superfamily and mediate the actions of estrogens...
  37. Nuclear cofactors in hormone signaling
    Hongwu Chen; Fiscal Year: 2012
    ..In addition, estrogen receptor-alpha (ERa) mediated activation of gene transcription also entails a dynamic assembly of nuclear cofactors ..
  38. Epigenetic Regulation of Breast Cancer Progression by the Proto-oncogene PELP1
    MONICA MANN; Fiscal Year: 2013
    ..Estrogen and its target estrogen receptor alpha (ER[unreadable]), a master transcriptional regulator, are implicated in the initiation and progression ..
  39. John P Lydon; Fiscal Year: 2016
    ..We have preliminary data illustrating that ablation of Ihh results in an increase in the expression of Estrogen Receptor alpha (ER1) and estrogen (E2) regulated genes in the endometrial epithelium...
  40. Hepatic Estrogen Signaling and Protection Against Insulin Resistance
    MELISSA NICOLE MARTINEZ; Fiscal Year: 2013
    ..Our overarching hypothesis is that hepatic estrogen signaling mediated by estrogen receptor alpha (ER1) promotes insulin sensitivity by bypassing the signaling defect to FoxO1 created by high-fat ..
  41. T Rajendra Kumar; Fiscal Year: 2016
    ..Our central hypothesis is that both estrogen receptor-1 (ESR1) and Indian hedgehog (IHH) contribute to growth of pituitary gonadotrope adenomas and inhibiting ..
  42. Screening of FoxA1-ER-DNA disruptors for development of breast cancer therapeutic
    Christopher L Warren; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Estrogen receptor a (ERa) is the major therapeutic target for breast cancer, and ERa binding at target genes in breast cancer cells is guided by DNA binding pioneer factor proteins such as FoxA1...
  43. ERalpha Regulation of Intestinal Homeostasis & Tumorigenesis
    Karen A Gould; Fiscal Year: 2010
    ..At least some of the effects of estrogens on CRC are likely mediated via the estrogen receptor a (ERa). Although ERa is normally expressed in colonic mucosa, ERa expression is absent in colorectal tumors...
  44. Molecular regulation of breast cancer growth
    Marsha A Moses; Fiscal Year: 2010
    ..In addition, the expression of the estrogen receptor alpha (ERalpha) was significantly downregulated by NGAL over-expression...
  45. Estrogen signaling transgenic mouse models
    Richard R Behringer; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Estrogen receptor alpha (ERa) and beta (ER[unreadable]) are members of the nuclear receptor superfamily and mediate the actions of estrogens...
  46. Translational Insights into Estrogen Receptor alpha-Positive Luminal Breast Cance
    ROBERT DAVID SCHREIBER; Fiscal Year: 2013
    We have developed a novel mouse model of estrogen receptor-alpha positive (ER?+) mammary cancer in STAT1-/- mice that shows remarkable resemblance to ER?+ luminal breast cancer in humans...
  47. Dissecting Estrogen Control of Sexual Differentiation of the Brain
    Jessica Tollkuhn; Fiscal Year: 2010
    ..Through chromatin immunoprecipitation analysis (ChIP), I will demonstrate the direct recruitment of estrogen receptor alpha (ERa) to the AR locus in the neonatal BNST of males...
  48. Shuyuan Yeh; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): It is generally agreed that ERa is expressed mainly in the stromal compartment, but not in the epithelial compartment of prostate...
  49. Investigation of ER alpha expression on male behavior under field conditions
    Brian Keane; Fiscal Year: 2013
    ..Data from laboratory studies demonstrate that estrogen, acting via estrogen receptor alpha (ER?), influences many aspects of sociosexual behavior in male mammals including affiliation, ..
  50. Epigenetic and Behavioral Effects of BPA Exposure
    JENNIFER T WOLSTENHOLME; Fiscal Year: 2013
    ..In our model, BPA exposure decreases methylation of estrogen receptor alpha...
  51. BRCA1 IN GENE REGULATION AND TUMOR SUPPRESSION
    Rong Li; Fiscal Year: 2010
    ..BRCA1 has been reported to bind to estrogen receptor alpha (ERalpha) and modulate its transcriptional activity...
  52. Timothy L Lash; Fiscal Year: 2016
    ..About one-third are pre-menopausal and two-thirds have tumors that express estrogen receptor alpha (ER[unreadable])...
  53. SUZANNE DANIELA CONZEN; Fiscal Year: 2016
    ..g. SGK1) and phosphatases (e.g. MKP1) required for GR-mediated cell survival in estrogen receptor, progesterone receptor and HER2-negative BC (triple-negative BC or TNBC) models...
  54. Elaine T Alarid; Fiscal Year: 2015
    ..challenge in the clinical management of breast cancer is why certain patients with ER+ tumors that express estrogen receptor-1 (ER1) do not benefit from hormonal therapies...
  55. The Role of PARP-1 in Hormone-Regulated Transcription
    William Kraus; Fiscal Year: 2007
    ..understanding of the molecular mechanisms underlying the control of gene expression by E2 acting through estrogen receptor alpha (ERa), a ligand-regulated, DMA-binding transcription factor...
  56. Role of AIB3 in Mammary Gland and Breast Cancer
    Jianming Xu; Fiscal Year: 2009
    ..Our data demonstrated that transcriptional capabilities of ERa and PR are significantly impaired in AIB3 deficient cells;AIB3 is highly expressed in the mammary epithelial cells ..
  57. Mechanisms Underlying ER-Negative Breast Cancer
    Dorraya El Ashry; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Loss of estrogen receptor alpha (ERa) in breast cancer correlates with a more aggressive, tamoxifen resistant phenotype...
  58. Plant-Derived Estrogens and Cell Proliferation
    Emma Shtivelman; Fiscal Year: 2011
    ..There are two ER subtypes, ERa and ERb. Studies indicate that the beneficial effect of estrogens on fat accumulation is mediated by ERa...
  59. Prakash S Nagarkatti; Fiscal Year: 2014
    ..Aim# 3 will investigate the role of ERa in DES induced apoptosis and development of autoimmunity...
  60. William G Helferich; Fiscal Year: 2015
    ..of whether these botanical estrogens have activities similar to or distinct from estradiol or selective estrogen receptor modulators (SERMs)...
  61. The Role of the Aryl Hy drocarbon Receptor in the Ovary
    Jodi A Flaws; Fiscal Year: 2010
    ..estradiol synthesis and follicular growth in AhRKO mice and 4) the AhR interacts with the promoters of FSHR, LHR, ERa, ER? and selected steroidogenic enzymes...
  62. Xianglin Shi; Fiscal Year: 2015
    ..Specific Aim 1. In vitro and in vivo investigation of antioxidant properties of C3G. Electron spin resonance (ESR) spin trapping will be used to determine the reaction rates of C3G toward hydroxyl (7OH) and superoxide (O27-) ..
  63. MECHANISMS OF ESTROGEN RECEPTOR REGULATION
    Ronald J Weigel; Fiscal Year: 2010
    The expression of estrogen receptor-alpha (ERa) is critical for establishing the hormone responsive phenotype of breast cancers...
  64. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
    ..abstract_text> ..
  65. Estrogen Metabolism and Action in Prostate Cancer Etiology in PCPT
    Ashraful Hoque; Fiscal Year: 2007
    ..Two estrogen receptors, ESR-a (ESR1) and ESR-3 (ESR2), are present in the human prostate and are the principal mediators of estrogen actions in ..
  66. VASCULAR ESTROGEN RECEPTORS--MOLECULAR MECHANISMS
    Michael Mendelsohn; Fiscal Year: 2001
    ..In non-vascular cells, estrogen's effects are mediated through the classic estrogen receptor, now called ERa. Very recently, a second estrogen receptor, ERb, was discovered in rat prostate...
  67. TUMOR SUPPRESSOR LIKE ACTIVITY OF ESTROGEN RECEPTOR
    SAMUEL BROOKS; Fiscal Year: 2004
    ..evidence from the literature and from the applicant's laboratory points toward the physical interaction of estrogen receptor-a (ERa), p53 and hdm2. There are a number of ramifications, real and hypothesized, of this phenomenon...
  68. DongBao Chen; Fiscal Year: 2016
    The hypothesis of this renewal grant is that, on binding to estrogen receptors (i.e., ERa and ER(3) on the plasma membranes, estrogen rapidly activates receptor subtype-specific intracellular signaling pathways (i.e...