Gene Symbol: ER
Description: estrogen receptor 1
Alias: ESR, ESRA, ESTRR, Era, NR3A1, estrogen receptor, E2 receptor alpha, ER-alpha, estradiol receptor, estrogen nuclear receptor alpha, estrogen receptor alpha E1-E2-1-2, estrogen receptor alpha E1-N2-E2-1-2, nuclear receptor subfamily 3 group A member 1, oestrogen receptor alpha
Species: human
Products:     ER

Top Publications

  1. Teng J, Wang Z, Jarrard D, Bjorling D. Roles of estrogen receptor alpha and beta in modulating urothelial cell proliferation. Endocr Relat Cancer. 2008;15:351-64 pubmed publisher
    ..The aim of this study was to determine the extent to which each ER subtype contributes to urothelial cell proliferation and their possible involvement in the regulation of the cell ..
  2. He S, Sun J, Li L, Davie J. Differential intranuclear organization of transcription factors Sp1 and Sp3. Mol Biol Cell. 2005;16:4073-83 pubmed
    ..studies demonstrate that Sp1 and Sp3 associate with histone deacetylases 1 and 2 and with the estrogen receptor alpha, albeit at low frequencies in MCF-7 cells...
  3. Dhasarathy A, Kajita M, Wade P. The transcription factor snail mediates epithelial to mesenchymal transitions by repression of estrogen receptor-alpha. Mol Endocrinol. 2007;21:2907-18 pubmed
    The estrogen receptor (ER)-alpha (ESR1) is a key regulatory molecule in mammary epithelial cell development...
  4. Chen Y, Jiang X, Xu L, Li X, Cao F, Li L, et al. Association of ER-alpha gene polymorphism with metabolic phenotypes in Chinese Hans. Lipids. 2009;44:719-23 pubmed publisher
    Recently, two polymorphisms (rs1884052 and rs3778099) of estrogen receptor alpha (ER-alpha) gene were identified as being associated with primary quantitative bone mineral density (BMD) in a genome-wide association (GWA) study in ..
  5. Acconcia F, Ascenzi P, Bocedi A, Spisni E, Tomasi V, Trentalance A, et al. Palmitoylation-dependent estrogen receptor alpha membrane localization: regulation by 17beta-estradiol. Mol Biol Cell. 2005;16:231-7 pubmed
    A fraction of the nuclear estrogen receptor alpha (ERalpha) is localized to the plasma membrane region of 17beta-estradiol (E2) target cells. We previously reported that ERalpha is a palmitoylated protein...
  6. Fletcher O, Johnson N, Orr N, Hosking F, Gibson L, Walker K, et al. Novel breast cancer susceptibility locus at 9q31.2: results of a genome-wide association study. J Natl Cancer Inst. 2011;103:425-35 pubmed publisher
    ..We also identified two variants (rs3734805 and rs9383938) mapping to 6q25.1 estrogen receptor 1 (ESR1), which were associated with breast cancer in subjects of northern European ancestry (rs3734805: OR =..
  7. Koller D, Zheng H, Karasik D, Yerges Armstrong L, Liu C, McGuigan F, et al. Meta-analysis of genome-wide studies identifies WNT16 and ESR1 SNPs associated with bone mineral density in premenopausal women. J Bone Miner Res. 2013;28:547-58 pubmed publisher
    ..These data support the hypothesis that variants in these genes of known skeletal function also affect BMD during the premenopausal period. ..
  8. Mirza S, Sharma G, Prasad C, Parshad R, Srivastava A, Gupta S, et al. Promoter hypermethylation of TMS1, BRCA1, ERalpha and PRB in serum and tumor DNA of invasive ductal breast carcinoma patients. Life Sci. 2007;81:280-7 pubmed
    ..females, especially in younger age group in India; a large proportion of these tumors are often aggressive and ER and/or PR negative...
  9. Masuyama H, Hiramatsu Y. Involvement of suppressor for Gal 1 in the ubiquitin/proteasome-mediated degradation of estrogen receptors. J Biol Chem. 2004;279:12020-6 pubmed
    ..experiments, we examined the potential role of SUG1 in the proteasome-mediated degradation of estrogen receptors (ER)alpha and -beta. Both ERs interacted with SUG1 in a ligand-dependent manner...

More Information

Publications405 found, 100 shown here

  1. Likhite V, Cass E, Anderson S, Yates J, Nardulli A. Interaction of estrogen receptor alpha with 3-methyladenine DNA glycosylase modulates transcription and DNA repair. J Biol Chem. 2004;279:16875-82 pubmed
    b>Estrogen receptor alpha (ERalpha) interacts with basal transcription factors, coregulatory proteins, and chromatin modifiers to initiate transcription of the target genes...
  2. Wang K, Shi D, Sun L, Jiang X, Lu Y, Dai J, et al. Association of estrogen receptor alpha gene polymorphisms with bone mineral density: a meta-analysis. Chin Med J (Engl). 2012;125:2589-97 pubmed
    A number of studies have examined the association between estrogen receptor alpha (ESR-?) gene polymorphisms and bone mineral density (BMD), but previous studies of ESR-? gene XbaI (rs9340799) and PvuII (rs2234693) polymorphisms have ..
  3. Han H, Yu E, Song J, Park J, Jang S, Choi J. The estrogen receptor alpha pathway induces oncogenic Wip1 phosphatase gene expression. Mol Cancer Res. 2009;7:713-23 pubmed publisher
    ..Direct binding of estrogen receptor (ER)alpha to the Wip1 promoter after E(2) treatment was confirmed by a chromatin immunoprecipitation assay ..
  4. Poelzl G, Kasai Y, Mochizuki N, Shaul P, Brown M, Mendelsohn M. Specific association of estrogen receptor beta with the cell cycle spindle assembly checkpoint protein, MAD2. Proc Natl Acad Sci U S A. 2000;97:2836-9 pubmed
    ..These data identify a link between ERbeta and MAD2 of potential importance to regulation of the cell cycle and support a function of ERbeta distinct from the established role of ERs as transcription factors. ..
  5. Meng J, Mu X, Wang Y. Influence of the XbaI polymorphism in the estrogen receptor-? gene on human spermatogenic defects. Genet Mol Res. 2013;12:1808-15 pubmed publisher
    Polymorphisms of estrogen receptor (ER) genes have been implicated in male infertility, but studies of this association have produced conflicting results...
  6. Jeselsohn R, Yelensky R, Buchwalter G, Frampton G, Meric Bernstam F, Gonzalez Angulo A, et al. Emergence of constitutively active estrogen receptor-? mutations in pretreated advanced estrogen receptor-positive breast cancer. Clin Cancer Res. 2014;20:1757-1767 pubmed publisher
    We undertook this study to determine the prevalence of estrogen receptor (ER) ? (ESR1) mutations throughout the natural history of hormone-dependent breast cancer and to delineate the functional roles of the most commonly detected ..
  7. Limer K, Pye S, Thomson W, Boonen S, Borghs H, Vanderschueren D, et al. Genetic variation in sex hormone genes influences heel ultrasound parameters in middle-aged and elderly men: results from the European Male Aging Study (EMAS). J Bone Miner Res. 2009;24:314-23 pubmed publisher
  8. Azuma K, Horie K, Inoue S, Ouchi Y, Sakai R. Analysis of estrogen receptor alpha signaling complex at the plasma membrane. FEBS Lett. 2004;577:339-44 pubmed
    There is accumulating evidence that the estrogen receptor (ER) can transduce specific signals at the plasma membrane...
  9. Gustafsson N, Zhao C, Gustafsson J, Dahlman Wright K. RBCK1 drives breast cancer cell proliferation by promoting transcription of estrogen receptor alpha and cyclin B1. Cancer Res. 2010;70:1265-74 pubmed publisher
    ..Here, we report an important role in estrogen receptor alpha (ERalpha)-positive breast cancer cells for the protein kinase C1 (PKC1)-interacting protein RBCK1 in ..
  10. Sentis S, Le Romancer M, Bianchin C, Rostan M, Corbo L. Sumoylation of the estrogen receptor alpha hinge region regulates its transcriptional activity. Mol Endocrinol. 2005;19:2671-84 pubmed
    ..physiology of the mammary gland and breast cancer development primarily through binding to its receptor, the estrogen receptor alpha (ERalpha)...
  11. Xu C, Guo J, Jiang Z, Xie S, Shen J, Shen J, et al. Prognostic role of estrogen receptor alpha and estrogen receptor beta in gastric cancer. Ann Surg Oncol. 2010;17:2503-9 pubmed publisher
    The presence of estrogen receptor alpha (ERalpha) and estrogen receptor beta (ERbeta) have been reported in cell and tissue level in gastric cancer, but its impact on patients' survival remains unclear...
  12. Koukouras D, Marioli D, Papadopoulos K, Adonakis G, Armeni A, Georgopoulos N, et al. Association of estrogen receptor alpha (ER?) gene polymorphisms with endometrial thickness and lipid profile in women with breast cancer treated with aromatase inhibitors. Gynecol Endocrinol. 2012;28:859-62 pubmed publisher
    ..The aim of the present study was to evaluate the effect of PvuII and XbaI polymorphisms of the ER? gene at ??s treatment's adverse effects in post-menopausal women with breast cancer...
  13. Petz L, Ziegler Y, Loven M, Nardulli A. Estrogen receptor alpha and activating protein-1 mediate estrogen responsiveness of the progesterone receptor gene in MCF-7 breast cancer cells. Endocrinology. 2002;143:4583-91 pubmed
    ..Purified estrogen receptor (ER) enhanced binding of Fos and Jun to the +90 AP-1 site and bound to an adjacent imperfect ERE half-site...
  14. Zurita M, Lara P, del Moral R, Torres B, Linares Fernández J, Arrabal S, et al. Hypermethylated 14-3-3-sigma and ESR1 gene promoters in serum as candidate biomarkers for the diagnosis and treatment efficacy of breast cancer metastasis. BMC Cancer. 2010;10:217 pubmed publisher
  15. Hu Z, Song C, Lu J, Luo J, Shen Z, Huang W, et al. A multigenic study on breast cancer risk associated with genetic polymorphisms of ER Alpha, COMT and CYP19 gene in BRCA1/BRCA2 negative Shanghai women with early onset breast cancer or affected relatives. J Cancer Res Clin Oncol. 2007;133:969-78 pubmed
    ..between genetic polymorphisms in genes encoding estrogen metabolizing, estrogen biosynthesizing enzyme and estrogen receptor and the breast cancer risk in BRCA1/BRCA2 negative Shanghai women, we conducted a case-control study ..
  16. Pineda B, Hermenegildo C, Tarín J, Laporta P, Cano A, García Pérez M. Alleles and haplotypes of the estrogen receptor alpha gene are associated with an increased risk of spontaneous abortion. Fertil Steril. 2010;93:1809-15 pubmed publisher
    To investigate whether polymorphisms in estrogen receptor alpha (ERalpha) or beta (ERbeta) genes are associated with a risk of miscarriage.
  17. Lee H, Bai W. Regulation of estrogen receptor nuclear export by ligand-induced and p38-mediated receptor phosphorylation. Mol Cell Biol. 2002;22:5835-45 pubmed
    ..Our previous study showed that p38 mitogen-activated protein kinase was involved in estrogen receptor activation by estrogens and MEKK1...
  18. Lo R, Burgoon L, MacPherson L, Ahmed S, Matthews J. Estrogen receptor-dependent regulation of CYP2B6 in human breast cancer cells. Biochim Biophys Acta. 2010;1799:469-79 pubmed publisher
    b>Estrogen receptor alpha (ERalpha) mediates the biological actions of estrogens and also contributes to the development and progression of breast cancer...
  19. Zhang Y, Eades G, Yao Y, Li Q, Zhou Q. Estrogen receptor ? signaling regulates breast tumor-initiating cells by down-regulating miR-140 which targets the transcription factor SOX2. J Biol Chem. 2012;287:41514-22 pubmed publisher
    ..However, the role of miR-140 in breast tumorigenesis is unclear. We initiated studies that examined estrogen receptor ? (ER?) signaling in the tissue-specific regulation of miR-140 in breast cancer...
  20. Xu H, Long J, Li M, Deng H. Interaction effects between estrogen receptor alpha and vitamin D receptor genes on age at menarche in Chinese women. Acta Pharmacol Sin. 2005;26:860-4 pubmed
    To evaluate whether estrogen receptor alpha (ER-alpha) and vitamin D receptor (VDR) genes are associated with the age at menarche in Chinese women...
  21. Ross Innes C, Stark R, Holmes K, Schmidt D, Spyrou C, Russell R, et al. Cooperative interaction between retinoic acid receptor-alpha and estrogen receptor in breast cancer. Genes Dev. 2010;24:171-82 pubmed publisher
    ..We now show that RAR alpha is required for efficient estrogen receptor-alpha (ER)-mediated transcription and cell proliferation...
  22. Lopez Garcia J, Periyasamy M, Thomas R, Christian M, Leao M, Jat P, et al. ZNF366 is an estrogen receptor corepressor that acts through CtBP and histone deacetylases. Nucleic Acids Res. 2006;34:6126-36 pubmed
    The regulation of gene expression by estrogen receptor-alpha (ERalpha) requires the coordinated and temporal recruitment of diverse sets of transcriptional co-regulator complexes, which mediate nucleosome remodelling and histone ..
  23. Magri F, Capelli V, Rotondi M, Leporati P, La Manna L, Ruggiero R, et al. Expression of estrogen and androgen receptors in differentiated thyroid cancer: an additional criterion to assess the patient's risk. Endocr Relat Cancer. 2012;19:463-71 pubmed publisher
    b>Estrogen receptor (ER) and androgen receptor (AR) may be expressed in thyroid tumors, but their prognostic role is controversial. We investigated whether ER and AR expressions could confer a more aggressive phenotype to thyroid tumors...
  24. Chen J, Eshete M, Alworth W, Yager J. Binding of MCF-7 cell mitochondrial proteins and recombinant human estrogen receptors alpha and beta to human mitochondrial DNA estrogen response elements. J Cell Biochem. 2004;93:358-73 pubmed
    ..mitochondrial DNA (mtDNA)-encoded genes and mitochondrial respiratory chain (MRC) activity via estrogen receptors (ER)...
  25. Ye Y, Xiao Y, Wang W, Yearsley K, Gao J, Barsky S. ERalpha suppresses slug expression directly by transcriptional repression. Biochem J. 2008;416:179-87 pubmed publisher
    Two of the most common signalling pathways in breast cancer are the ER (oestrogen receptor) ligand activation pathway and the E-cadherin snai1 slug EMT (epithelial-mesenchymal transition) pathway...
  26. Pan X, Zhou T, Tai Y, Wang C, Zhao J, Cao Y, et al. Elevated expression of CUEDC2 protein confers endocrine resistance in breast cancer. Nat Med. 2011;17:708-14 pubmed publisher
    ..Although reduced expression of estrogen receptor-? (ER-?) is a known contributing factor to endocrine resistance, the mechanism of ER-? downregulation in ..
  27. Tokunaga E, Oki E, Kimura Y, Yamanaka T, Egashira A, Nishida K, et al. Coexistence of the loss of heterozygosity at the PTEN locus and HER2 overexpression enhances the Akt activity thus leading to a negative progesterone receptor expression in breast carcinoma. Breast Cancer Res Treat. 2007;101:249-57 pubmed
    ..The association between Akt activation and PR negative expression was observed even in the ER-positive cases...
  28. Duplessis T, Williams C, Hill S, Rowan B. Phosphorylation of Estrogen Receptor ? at serine 118 directs recruitment of promoter complexes and gene-specific transcription. Endocrinology. 2011;152:2517-26 pubmed publisher
    Phosphorylation of estrogen receptor ? (ER?) is important for receptor function, although the role of specific ER? phosphorylation sites in ER?-mediated transcription remains to be fully evaluated...
  29. Bozkurt K, Kapucuoglu N. Investigation of immunohistochemical ER?, ER? and ER?cx expressions in normal and neoplastic breast tissues. Pathol Res Pract. 2012;208:133-9 pubmed publisher
    b>Estrogen receptor alpha (ER?) is a well-established prognostic marker in breast cancer. The role of estrogen receptor beta (ER?) in breast cancers is still under investigation...
  30. Karmakar S, Gao T, Pace M, Oesterreich S, Smith C. Cooperative activation of cyclin D1 and progesterone receptor gene expression by the SRC-3 coactivator and SMRT corepressor. Mol Endocrinol. 2010;24:1187-202 pubmed publisher
    Although the ability of coactivators to enhance the expression of estrogen receptor-alpha (ERalpha) target genes is well established, the role of corepressors in regulating 17beta-estradiol (E2)-induced gene expression is poorly ..
  31. Oesterreich S, Zhang Q, Hopp T, Fuqua S, Michaelis M, Zhao H, et al. Tamoxifen-bound estrogen receptor (ER) strongly interacts with the nuclear matrix protein HET/SAF-B, a novel inhibitor of ER-mediated transactivation. Mol Endocrinol. 2000;14:369-81 pubmed
    The estrogen receptor (ER) is a ligand-dependent transcription factor that acts in a cell- and promoter-specific manner. Evidence suggests that the activity of the ER can be regulated by a number of other stimuli (e.g...
  32. Fujita T, Kobayashi Y, Wada O, Tateishi Y, Kitada L, Yamamoto Y, et al. Full activation of estrogen receptor alpha activation function-1 induces proliferation of breast cancer cells. J Biol Chem. 2003;278:26704-14 pubmed
    ..Recently, one of the phthalate esters, n-butylbenzyl phthalate (BBP), has been shown to induce estrogen receptor-mediated responses...
  33. Wise B, Demissie S, Cupples L, Felson D, Yang M, Shearman A, et al. The relationship of estrogen receptor-alpha and -beta genes with osteoarthritis of the hand. J Rheumatol. 2009;36:2772-9 pubmed publisher
    ..OA) and single-nucleotide polymorphisms (SNP) in 2 candidate genes associated with OA in other joints: estrogen receptor alpha (ESR1) and beta (ESR2)...
  34. Safarinejad M, Shafiei N, Safarinejad S. Association of polymorphisms in the estrogen receptors alpha, and beta (ESR1, ESR2) with the occurrence of male infertility and semen parameters. J Steroid Biochem Mol Biol. 2010;122:193-203 pubmed publisher
    ..Polymorphisms of the estrogen receptor (ER) genes, have been implicated in male infertility, however, comprehensive data are lacking...
  35. Mansur A, Nogueira C, Strunz C, Aldrighi J, Ramires J. Genetic polymorphisms of estrogen receptors in patients with premature coronary artery disease. Arch Med Res. 2005;36:511-7 pubmed
    Estrogen protects against atherosclerosis through its genomic/nongenomic effects. Estrogen receptors (ESR) alpha (1) and beta (2) mediate much estrogen action...
  36. Lecomte J, Flament S, Salamone S, Boisbrun M, Mazerbourg S, Chapleur Y, et al. Disruption of ERalpha signalling pathway by PPARgamma agonists: evidences of PPARgamma-independent events in two hormone-dependent breast cancer cell lines. Breast Cancer Res Treat. 2008;112:437-51 pubmed publisher
    ..agonists, Rosiglitazone (RGZ), Ciglitazone (CGZ), Troglitazone (TGZ) and the natural agonist 15d-PGJ(2), on estrogen receptor alpha (ERalpha) signalling pathway in two hormone-dependent breast cancer cell lines, MCF-7 and ZR-75-1...
  37. Scafonas A, Reszka A, Kimmel D, Hou X, Su Q, Birzin E, et al. Agonist-like SERM effects on ERalpha-mediated repression of MMP1 promoter activity predict in vivo effects on bone and uterus. J Steroid Biochem Mol Biol. 2008;110:197-206 pubmed publisher
    ..To date, the molecular mode of action of estradiol and selective estradiol receptor modulators (SERMs) on bone is not fully understood...
  38. Kang L, Zhang X, Xie Y, Tu Y, Wang D, Liu Z, et al. Involvement of estrogen receptor variant ER-alpha36, not GPR30, in nongenomic estrogen signaling. Mol Endocrinol. 2010;24:709-21 pubmed publisher
    ..that knockdown of GPR30 expression in breast cancer SK-BR-3 cells down-regulated the expression levels of estrogen receptor (ER)-alpha36, a variant of ER-alpha...
  39. Wormke M, Stoner M, Saville B, Walker K, Abdelrahim M, Burghardt R, et al. The aryl hydrocarbon receptor mediates degradation of estrogen receptor alpha through activation of proteasomes. Mol Cell Biol. 2003;23:1843-55 pubmed
    ..T47D, and MCF-7 human breast cancer cells with TCDD induces proteasome-dependent degradation of endogenous estrogen receptor alpha (ERalpha)...
  40. Ayvaz O, Ekmekci A, Baltaci V, Onen H, Unsal E. Evaluation of in vitro fertilization parameters and estrogen receptor alpha gene polymorphisms for women with unexplained infertility. J Assist Reprod Genet. 2009;26:503-10 pubmed publisher
    ..Long TA repeat in promotor was found to be associated with low fertilization rate. Polymorphisms at the ESR1 gene are associated with infertility in this Turkish infertile women population. ..
  41. Song R, McPherson R, Adam L, Bao Y, Shupnik M, Kumar R, et al. Linkage of rapid estrogen action to MAPK activation by ERalpha-Shc association and Shc pathway activation. Mol Endocrinol. 2002;16:116-27 pubmed
    ..The E2-induced morphological changes were prevented by antiestrogen. Together our results demonstrate that ERalpha can mediate the rapid effects of E2 on Shc, MAPK, Elk-1, and morphological changes in breast cancer cells ..
  42. Dutertre M, Smith C. Ligand-independent interactions of p160/steroid receptor coactivators and CREB-binding protein (CBP) with estrogen receptor-alpha: regulation by phosphorylation sites in the A/B region depends on other receptor domains. Mol Endocrinol. 2003;17:1296-314 pubmed
    b>Estrogen receptor (ER)alpha and ERbeta are transcription factors that can be activated by both ligand binding and growth factor signaling...
  43. Hsiao P, Fryer C, Trotter K, Wang W, Archer T. BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation. Mol Cell Biol. 2003;23:6210-20 pubmed
    ..Thus, in addition to previously identified BAF250, BAF60a may provide another critical and direct link between nuclear receptors and the BRG1 complex that is required for promoter recruitment and subsequent chromatin remodeling. ..
  44. Cordts E, Santos A, Peluso C, Bianco B, Barbosa C, Christofolini D. Risk of premature ovarian failure is associated to the PvuII polymorphism at estrogen receptor gene ESR1. J Assist Reprod Genet. 2012;29:1421-5 pubmed publisher important role in the human reproductive system and it action is mediated mainly by two specific receptors: ? (ER?) and ? (ER?)...
  45. Corbo R, Gambina G, Ruggeri M, Scacchi R. Association of estrogen receptor alpha (ESR1) PvuII and XbaI polymorphisms with sporadic Alzheimer's disease and their effect on apolipoprotein E concentrations. Dement Geriatr Cogn Disord. 2006;22:67-72 pubmed
    ..most of the estrogen neuroprotective effect is mediated by receptors, we studied the associations between estrogen receptor alpha (ESR1) polymorphisms (PvuII and XbaI) and AD, and their interactions with apolipoprotein E (APOE) ..
  46. Stacey S, Sulem P, Zanon C, Gudjonsson S, Thorleifsson G, Helgason A, et al. Ancestry-shift refinement mapping of the C6orf97-ESR1 breast cancer susceptibility locus. PLoS Genet. 2010;6:e1001029 pubmed publisher
    ..The locus is on 6q25.1 in proximity to the C6orf97 and estrogen receptor alpha (ESR1) genes...
  47. Campbell R, Bhat Nakshatri P, Patel N, Constantinidou D, Ali S, Nakshatri H. Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: a new model for anti-estrogen resistance. J Biol Chem. 2001;276:9817-24 pubmed
    ..Anti-estrogens such as tamoxifen inhibit the growth of ER-positive breast cancers by reducing the expression of estrogen-regulated genes...
  48. Kurtev V, Margueron R, Kroboth K, Ogris E, Cavailles V, Seiser C. Transcriptional regulation by the repressor of estrogen receptor activity via recruitment of histone deacetylases. J Biol Chem. 2004;279:24834-43 pubmed
    ..Using the yeast two-hybrid system, we isolated the repressor of estrogen receptor activity (REA) as a novel HDAC1-associated protein...
  49. Tiemeier H, Schuit S, den Heijer T, van Meurs J, van Tuijl H, Hofman A, et al. Estrogen receptor alpha gene polymorphisms and anxiety disorder in an elderly population. Mol Psychiatry. 2005;10:806-7 pubmed
  50. Ye Y, Xiao Y, Wang W, Yearsley K, Gao J, Shetuni B, et al. ERalpha signaling through slug regulates E-cadherin and EMT. Oncogene. 2010;29:1451-62 pubmed publisher
    ..In human breast cancer cases, there was a strong inverse correlation between slug and ERalpha and E-cadherin immunoreactivity. Our findings indicate that ERalpha signaling through slug regulates E-cadherin and EMT. ..
  51. Chen D, Riedl T, Washbrook E, Pace P, Coombes R, Egly J, et al. Activation of estrogen receptor alpha by S118 phosphorylation involves a ligand-dependent interaction with TFIIH and participation of CDK7. Mol Cell. 2000;6:127-37 pubmed
    Phosphorylation of the estrogen receptor alpha (ERalpha) N-terminal transcription activation function AF1 at serine 118 (S118) modulates its activity...
  52. Wärnmark A, Treuter E, Gustafsson J, Hubbard R, Brzozowski A, Pike A. Interaction of transcriptional intermediary factor 2 nuclear receptor box peptides with the coactivator binding site of estrogen receptor alpha. J Biol Chem. 2002;277:21862-8 pubmed
    ..To better understand the structural basis of motif recognition, we characterized the interaction between estrogen receptor alpha and the NR box regions of the p160 coactivator TIF2...
  53. Molvarec A, Nagy B, Kovacs M, Walentin S, Imreh E, Rigo J, et al. Lipid, haemostatic and inflammatory variables in relation to the estrogen receptor alpha (ESR1) PvuII and XbaI gene polymorphisms. Clin Chim Acta. 2007;380:157-64 pubmed
    ..Our aim was to determine whether estrogen receptor alpha (ESR1) PvuII and XbaI gene polymorphisms can influence lipid, haemostatic and inflammatory variables ..
  54. Zwart W, Griekspoor A, Berno V, Lakeman K, Jalink K, Mancini M, et al. PKA-induced resistance to tamoxifen is associated with an altered orientation of ERalpha towards co-activator SRC-1. EMBO J. 2007;26:3534-44 pubmed breast cancer, where the anti-estrogen tamoxifen acquires agonistic properties for transactivating estrogen receptor alpha (ERalpha)...
  55. Simoncini T, Rabkin E, Liao J. Molecular basis of cell membrane estrogen receptor interaction with phosphatidylinositol 3-kinase in endothelial cells. Arterioscler Thromb Vasc Biol. 2003;23:198-203 pubmed
    ..By interacting with phosphatidylinositol 3-kinase (PI3K), estrogen receptor (ER) alpha leads to activation of protein kinase Akt and to subsequent increase in endothelial nitric oxide ..
  56. Klinge C, Jernigan S, Mattingly K, Risinger K, Zhang J. Estrogen response element-dependent regulation of transcriptional activation of estrogen receptors alpha and beta by coactivators and corepressors. J Mol Endocrinol. 2004;33:387-410 pubmed
    ..estrogen receptors alpha and beta (ERalpha and ERbeta) stimulate gene transcription is through direct ER interaction with specific DNA sequences, estrogen response elements (EREs)...
  57. Porrello E, Monti M, Sinforiani E, Cairati M, Guaita A, Montomoli C, et al. Estrogen receptor alpha and APOEepsilon4 polymorphisms interact to increase risk for sporadic AD in Italian females. Eur J Neurol. 2006;13:639-44 pubmed
    ..To investigate the role of two single nucleotide polymorphisms in the first intron of the ER-alpha gene, denominated PvuII and XbaI, and their interaction with the known AD susceptibility gene APOE, we ..
  58. Kjaergaard A, Ellervik C, Tybjaerg Hansen A, Axelsson C, Grønholdt M, Grande P, et al. Estrogen receptor alpha polymorphism and risk of cardiovascular disease, cancer, and hip fracture: cross-sectional, cohort, and case-control studies and a meta-analysis. Circulation. 2007;115:861-71 pubmed
    We hypothesized that the estrogen receptor alpha (ESR1) IVS1-397T/C polymorphism affects high-density lipoprotein cholesterol response to hormone replacement therapy and risk of cardiovascular disease (CVD), cancer of reproductive organs,..
  59. Khattri A, Pandey R, Gupta N, Chakravarty B, Deendayal M, Singh L, et al. CA repeat and RsaI polymorphisms in ERbeta gene are not associated with infertility in Indian men. Int J Androl. 2009;32:81-7 pubmed
    ..Our results suggest that CA repeat length and RsaI polymorphisms in ERbeta are not associated with infertility in Indian men. ..
  60. Massart F, Marini F, Bianchi G, Minisola S, Luisetto G, Pirazzoli A, et al. Age-specific effects of estrogen receptors' polymorphisms on the bone traits in healthy fertile women: the BONTURNO study. Reprod Biol Endocrinol. 2009;7:32 pubmed publisher
    ..Common variants in the genes encoding for estrogen receptor alpha (ESR1) and beta (ESR2) are proposed as candidates for influencing bone phenotypes at the population ..
  61. Wang C, Mayer J, Mazumdar A, Fertuck K, Kim H, Brown M, et al. Estrogen induces c-myc gene expression via an upstream enhancer activated by the estrogen receptor and the AP-1 transcription factor. Mol Endocrinol. 2011;25:1527-38 pubmed publisher
    ..Estrogen rapidly induced c-myc expression in estrogen receptor (ER)-positive breast cancer cells...
  62. Fernandes I, Bastien Y, Wai T, Nygard K, Lin R, Cormier O, et al. Ligand-dependent nuclear receptor corepressor LCoR functions by histone deacetylase-dependent and -independent mechanisms. Mol Cell. 2003;11:139-50 pubmed
    ..LCoR binding to estrogen receptor alpha depends in part on residues in the coactivator binding pocket distinct from those bound by TIF-2...
  63. Kouzmenko A, Takeyama K, Ito S, Furutani T, Sawatsubashi S, Maki A, et al. Wnt/beta-catenin and estrogen signaling converge in vivo. J Biol Chem. 2004;279:40255-8 pubmed
    ..Using human colon and breast cancer cells, we found that estrogen receptor (ER) alpha- and beta-catenin precipitated within the same immunocomplexes, reciprocally enhanced the ..