EPHX2

Summary

Gene Symbol: EPHX2
Description: epoxide hydrolase 2
Alias: CEH, SEH, bifunctional epoxide hydrolase 2, epoxide hydratase, epoxide hydrolase 2, cytoplasmic, epoxide hydrolase 2, cytosolic, epoxide hydrolase, soluble
Species: human
Products:     EPHX2

Top Publications

  1. Beetham J, Tian T, Hammock B. cDNA cloning and expression of a soluble epoxide hydrolase from human liver. Arch Biochem Biophys. 1993;305:197-201 pubmed
    ..The recombinant protein was similar to soluble epoxide hydrolase isolated from human liver in terms of molecular weight, hydrolytic activity, inhibition, and immunoreactivity. ..
  2. Sandberg M, Hassett C, Adman E, Meijer J, Omiecinski C. Identification and functional characterization of human soluble epoxide hydrolase genetic polymorphisms. J Biol Chem. 2000;275:28873-81 pubmed
    Human soluble epoxide hydrolase (sEH), an enzyme directing the functional disposition of a variety of endogenous and xenobiotic-derived chemical epoxides, was characterized at the genomic level for interindividual variation capable of ..
  3. Fornage M, Boerwinkle E, Doris P, Jacobs D, Liu K, Wong N. Polymorphism of the soluble epoxide hydrolase is associated with coronary artery calcification in African-American subjects: The Coronary Artery Risk Development in Young Adults (CARDIA) study. Circulation. 2004;109:335-9 pubmed
    Modulation of endogenous epoxide levels by soluble epoxide hydrolase (sEH) in the endothelium represents an important mechanism in the regulation of cardiovascular function...
  4. Srivastava P, Sharma V, Kalonia D, Grant D. Polymorphisms in human soluble epoxide hydrolase: effects on enzyme activity, enzyme stability, and quaternary structure. Arch Biochem Biophys. 2004;427:164-9 pubmed
    ..However, the Arg287Gln and Arg103Cys/Arg287Gln mutants show increased concentration of the monomer. We conclude that the Arg287Gln polymorphism disrupts putative intra- and inter-monomeric salt-bridges responsible for dimerization. ..
  5. Fornage M, Lee C, Doris P, Bray M, Heiss G, Zeldin D, et al. The soluble epoxide hydrolase gene harbors sequence variation associated with susceptibility to and protection from incident ischemic stroke. Hum Mol Genet. 2005;14:2829-37 pubmed
    ..We investigated the association of polymorphisms in the soluble epoxide hydrolase gene (EPHX2) with incident ischemic stroke in African-Americans and Whites...
  6. Wei Q, Doris P, Pollizotto M, Boerwinkle E, Jacobs D, Siscovick D, et al. Sequence variation in the soluble epoxide hydrolase gene and subclinical coronary atherosclerosis: interaction with cigarette smoking. Atherosclerosis. 2007;190:26-34 pubmed
    Soluble epoxide hydrolase (EPHX2) catalyses the degradation of the vasoactive and anti-inflammatory epoxyeicosatrienoic acids and may play a role in the pathophysiology of atherosclerosis...
  7. Lee C, North K, Bray M, Fornage M, Seubert J, Newman J, et al. Genetic variation in soluble epoxide hydrolase (EPHX2) and risk of coronary heart disease: The Atherosclerosis Risk in Communities (ARIC) study. Hum Mol Genet. 2006;15:1640-9 pubmed
    ..We sought to determine whether genetic variation in soluble epoxide hydrolase (EPHX2) was associated with the risk of CHD...
  8. Sura P, Sura R, Enayetallah A, Grant D. Distribution and expression of soluble epoxide hydrolase in human brain. J Histochem Cytochem. 2008;56:551-9 pubmed publisher
    ..EETs are converted by soluble epoxide hydrolase (sEH) to the corresponding inactive diol metabolites...
  9. Sato K, Emi M, Ezura Y, Fujita Y, Takada D, Ishigami T, et al. Soluble epoxide hydrolase variant (Glu287Arg) modifies plasma total cholesterol and triglyceride phenotype in familial hypercholesterolemia: intrafamilial association study in an eight-generation hyperlipidemic kindred. J Hum Genet. 2004;49:29-34 pubmed
    ..Soluble epoxide hydrolase ( EPHX2, sEH) plays a role in disposition of epoxides in plasma lipoprotein particles...

More Information

Publications126 found, 100 shown here

  1. Burdon K, Lehtinen A, Langefeld C, Carr J, Rich S, Freedman B, et al. Genetic analysis of the soluble epoxide hydrolase gene, EPHX2, in subclinical cardiovascular disease in the Diabetes Heart Study. Diab Vasc Dis Res. 2008;5:128-34 pubmed publisher
    ..Consequently, epoxide hydrolase 2 (EPHX2) is a candidate cardiovascular disease (CVD) gene...
  2. Hoopes S, Gruzdev A, Edin M, Graves J, Bradbury J, Flake G, et al. Generation and characterization of epoxide hydrolase 3 (EPHX3)-deficient mice. PLoS ONE. 2017;12:e0175348 pubmed publisher
    ..Microsomal epoxide hydrolase (EPHX1, mEH) and soluble epoxide hydrolase (EPHX2, sEH) were identified >30 years ago and are capable of hydrolyzing EETs to DHETs...
  3. Xu J, Morisseau C, Hammock B. Expression and characterization of an epoxide hydrolase from Anopheles gambiae with high activity on epoxy fatty acids. Insect Biochem Mol Biol. 2014;54:42-52 pubmed publisher
    ..The study suggests there are mammalian sEH homologs in insects, and epoxy fatty acids may be important chemical mediators in insects.
  4. Blum M, Dogan I, Karber M, Rothe M, Schunck W. Chiral lipidomics of monoepoxy and monohydroxy metabolites derived from long-chain polyunsaturated fatty acids. J Lipid Res. 2019;60:135-148 pubmed publisher
    ..Ablation of the soluble epoxide hydrolase (sEH) gene resulted in specific alterations in the enantiomeric composition of endogenous monoepoxy metabolites...
  5. Wang Z, Fang Y, Teague J, Wong H, Morisseau C, Hammock B, et al. In Vitro Metabolism of Oprozomib, an Oral Proteasome Inhibitor: Role of Epoxide Hydrolases and Cytochrome P450s. Drug Metab Dispos. 2017;45:712-720 pubmed publisher
    ..epoxide hydrolases (EHs) and selective EH inhibitors in liver microsomes, microsomal EH (mEH) but not soluble EH (sEH) was found to be responsible for oprozomib diol formation...
  6. Xu J, Morisseau C, Yang J, Mamatha D, Hammock B. Epoxide hydrolase activities and epoxy fatty acids in the mosquito Culex quinquefasciatus. Insect Biochem Mol Biol. 2015;59:41-9 pubmed publisher
    ..activities on EETs can be inhibited by urea-based inhibitors designed for mammalian soluble epoxide hydrolases (sEH)...
  7. Toselli F, Fredenwall M, Svensson P, Li X, Johansson A, Weidolf L, et al. Oxetane Substrates of Human Microsomal Epoxide Hydrolase. Drug Metab Dispos. 2017;45:966-973 pubmed publisher
    ..were performed with and without inhibitors of cytochrome P450 (P450), mEH and soluble epoxide hydrolase (sEH). Reaction dependence on NADPH was investigated in subcellular fractions...
  8. Kodani S, Hammock B. The 2014 Bernard B. Brodie award lecture-epoxide hydrolases: drug metabolism to therapeutics for chronic pain. Drug Metab Dispos. 2015;43:788-802 pubmed publisher
    ..Similarly, the development of a novel class of therapeutics termed the soluble epoxide hydrolase (sEH) inhibitors was originally spurred by fundamental research exploring the biochemistry and physiology of the sEH...
  9. Kodani S, Morisseau C. Role of epoxy-fatty acids and epoxide hydrolases in the pathology of neuro-inflammation. Biochimie. 2019;159:59-65 pubmed publisher
    ..of epoxyeicosatrienoic acids (EETs) through blocking their hydrolytic degradation by soluble epoxide hydrolase (sEH) has been applied towards reducing the long-term damage associated with central neurologic insults...
  10. Cui Y, Li D, Morisseau C, Dong J, Yang J, Wan D, et al. Heavy chain single-domain antibodies to detect native human soluble epoxide hydrolase. Anal Bioanal Chem. 2015;407:7275-83 pubmed publisher
    The soluble epoxide hydrolase (sEH) is a potential pharmacological target for treating hypertension, vascular inflammation, pain, cancer, and other diseases...
  11. Yamanashi H, Boeglin W, Morisseau C, Davis R, Sulikowski G, Hammock B, et al. Catalytic activities of mammalian epoxide hydrolases with cis and trans fatty acid epoxides relevant to skin barrier function. J Lipid Res. 2018;59:684-695 pubmed publisher
    ..By contrast, human soluble EH [sEH (EPHX2)] and human or murine epoxide hydrolase-3 [EH3 (EPHX3)] hydrolyzed cis or trans allylic epoxides to ..
  12. Rand A, Helmer P, Inceoglu B, Hammock B, Morisseau C. LC-MS/MS Analysis of the Epoxides and Diols Derived from the Endocannabinoid Arachidonoyl Ethanolamide. Methods Mol Biol. 2018;1730:123-133 pubmed publisher
    ..method was used to measure EET-EA biotransformation to DHET-EAs by two human epoxide hydrolases: the soluble EH (sEH) and the microsomal EH (mEH)...
  13. Giacinti G, Carfora V, Caprioli A, Sagrafoli D, Marri N, Giangolini G, et al. Prevalence and characterization of methicillin-resistant Staphylococcus aureus carrying mecA or mecC and methicillin-susceptible Staphylococcus aureus in dairy sheep farms in central Italy. J Dairy Sci. 2017;100:7857-7863 pubmed publisher
    ..enterotoxin genes, the mecC-positive MRSA tested negative, whereas the ST (CC)1 mecA-positive MRSA harbored the seh gene. Among the 104 methicillin-susceptible S. aureus isolates examined for antimicrobial susceptibility, 63 (60...
  14. Praderio R, García Mitacek M, Nuñez Favre R, Rearte R, de la Sota R, Stornelli M. Uterine endometrial cytology, biopsy, bacteriology, and serum C-reactive protein in clinically healthy diestrus bitches. Theriogenology. 2019;131:153-161 pubmed publisher
    ..common observation was END (27/50), followed by normal endometrium (NE; 18/50), cystic endometrial hyperplasia (CEH; 2/50), atrophy (2/50) and fibrosis with degeneration of the endometrial glands (1/50)...
  15. Zhang C, Zheng L, Gui L, Lin J, Zhu Y, Deng W, et al. Soluble epoxide hydrolase inhibition with t-TUCB alleviates liver fibrosis and portal pressure in carbon tetrachloride-induced cirrhosis in rats. Clin Res Hepatol Gastroenterol. 2018;42:118-125 pubmed publisher
    ..Meanwhile, oxidative stress was also alleviated following inhibition of sEH in CCl4-induced models, as evidenced by down-regulated levels of malondialdehyde (MDA) and up-regulated ..
  16. Roche C, Besnier M, Cassel R, Harouki N, Coquerel D, Guerrot D, et al. Soluble epoxide hydrolase inhibition improves coronary endothelial function and prevents the development of cardiac alterations in obese insulin-resistant mice. Am J Physiol Heart Circ Physiol. 2015;308:H1020-9 pubmed publisher
    This study addressed the hypothesis that inhibiting the soluble epoxide hydrolase (sEH)-mediated degradation of epoxy-fatty acids, notably epoxyeicosatrienoic acids, has an additional impact against cardiovascular damage in insulin ..
  17. Pickens C, Sordillo L, Zhang C, Fenton J. Obesity is positively associated with arachidonic acid-derived 5- and 11-hydroxyeicosatetraenoic acid (HETE). Metabolism. 2017;70:177-191 pubmed publisher
    ..product, 11-HETE is marker of lipid peroxidation, and vicinal diols are formed through soluble epoxide hydrolase (sEH) metabolism of CYP epoxygenated PUFAs, therefore, these results indicate that obesity is likely associated with ..
  18. Fliers E, Boelen A, van Trotsenburg A. Central regulation of the hypothalamo-pituitary-thyroid (HPT) axis: focus on clinical aspects. Handb Clin Neurol. 2014;124:127-38 pubmed publisher
    ..Congenital or acquired dysfunction of the hypothalamus or pituitary gland may result in central hypothyroidism (CeH)...
  19. Liao J, Hwang S, Li H, Liu J, Hammock B, Yang G. Inhibition of Chronic Pancreatitis and Murine Pancreatic Intraepithelial Neoplasia by a Dual Inhibitor of c-RAF and Soluble Epoxide Hydrolase in LSL-KrasG¹²D/Pdx-1-Cre Mice. Anticancer Res. 2016;36:27-37 pubmed
    ..of arachidonic acid play a crucial role in promoting carcinogenesis, in which the soluble epoxide hydrolase (sEH), as a pro-inflammatory enzyme, generally inactivates anti-inflammatory epoxyeicosatrienoic acids (EETs)...
  20. Casaes Nunes R, Pires de Souza C, Pereira K, Del Aguila E, Flosi Paschoalin V. Identification and molecular phylogeny of coagulase-negative staphylococci isolates from Minas Frescal cheese in southeastern Brazil: Superantigenic toxin production and antibiotic resistance. J Dairy Sci. 2016;99:2641-2653 pubmed publisher
    ..multiple enterotoxin genes, with high incidence of sea and seb (90 and 70%, respectively), followed by sec/see, seh/sei, and sed with intermediate incidence (60, 50, and 40%, respectively), and, finally, seg/selk/selq/selr and selu ..
  21. Zhou Y, Yang J, Sun G, Liu T, Duan J, Zhou H, et al. Soluble epoxide hydrolase inhibitor 1-trifluoromethoxyphenyl-3- (1-propionylpiperidin-4-yl) urea attenuates bleomycin-induced pulmonary fibrosis in mice. Cell Tissue Res. 2016;363:399-409 pubmed publisher
    ..acid derived from the cytochrome P450 (CYP450) epoxygenases, are mainly metabolized by soluble epoxide hydrolase (sEH) to their corresponding diols...
  22. Okada T, Morino K, Nakagawa F, Tawa M, Kondo K, Sekine O, et al. N-3 Polyunsaturated Fatty Acids Decrease the Protein Expression of Soluble Epoxide Hydrolase via Oxidative Stress-Induced P38 Kinase in Rat Endothelial Cells. Nutrients. 2017;9: pubmed publisher
    ..diet improved acetylcholine-induced vasodilation and reduced the protein expression of soluble epoxide hydrolase (sEH), a key EET metabolic enzyme, in aortic strips...
  23. Paniagua Contreras G, Monroy Pérez E, Vaca Paniagua F, Rodríguez Moctezuma J, Vaca S. Expression of enterotoxin-coding genes in methicillin-resistant Staphylococcus aureus strains isolated from Mexican haemodialysis patients. Ann Clin Microbiol Antimicrob. 2014;13:55 pubmed publisher
    ..All 21 strains (100%) expressed the seg, seh, sei, eta, etb, or hla genes coding staphylococcal toxins. Eleven MRSA strains (52...
  24. Zhou Z, Zhang M, Li H, Yang H, Li X, Song X, et al. Prevalence and molecular characterization of Staphylococcus aureus isolated from goats in Chongqing, China. BMC Vet Res. 2017;13:352 pubmed publisher
    ..The most prevalent combination were seb?+?see and seb?+?tst. None of the S. aureus isolates harbored sea, sed, seh, eta and etb...
  25. Bonsaglia E, Silva N, Rossi B, Camargo C, Dantas S, Langoni H, et al. Molecular epidemiology of methicillin-susceptible Staphylococcus aureus (MSSA) isolated from milk of cows with subclinical mastitis. Microb Pathog. 2018;124:130-135 pubmed publisher
    ..PFGE), agr cluster (I, II, III and IV) typing, PCR for genes including enterotoxins (sea, seb, sec, sed, see, seg, seh, sei), toxic shock syndrome toxin (tsst-1), and Panton-Valentine leucocidin (pvl), as well as in vitro resistance ..
  26. Yao E, Tang Y, Liu X, Wang M. TPPU protects tau from H2O2-induced hyperphosphorylation in HEK293/tau cells by regulating PI3K/AKT/GSK-3? pathway. J Huazhong Univ Sci Technolog Med Sci. 2016;36:785-790 pubmed publisher
    ..Inhibition of soluble epoxide hydrolase (sEH) metabolism has been shown to effectively increase the accumulation of epoxyeicosatrienoic acids (EETs), which are ..
  27. Klipsic D, Landrock D, Martin G, McIntosh A, Landrock K, Mackie J, et al. Impact of SCP-2/SCP-x gene ablation and dietary cholesterol on hepatic lipid accumulation. Am J Physiol Gastrointest Liver Physiol. 2015;309:G387-99 pubmed publisher
    ..This exacerbation was associated both with loss of SCP-2 and concomitant downregulation of Ceh/Hsl, apolipoprotein B (ApoB), MTP, and/or L-FABP protein expression...
  28. Wu X, Yang J, Morisseau C, Robertson L, Hammock B, Lehmler H. 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) Decreases Hepatic and Systemic Ratios of Epoxide to Diol Metabolites of Unsaturated Fatty Acids in Male Rats. Toxicol Sci. 2016;152:309-22 pubmed publisher
    ..several epoxides to diol metabolites formed via the cytochrome P450 (P450) monooxygenase/soluble epoxide hydrolase (sEH) pathway from polyunsaturated fatty acids displayed a dose-dependent decrease in the liver and plasma, whereas ..
  29. Schubert J, Podkowik M, Bystroń J, Bania J. Production of staphylococcal enterotoxins in microbial broth and milk by Staphylococcus aureus strains harboring seh gene. Int J Food Microbiol. 2016;235:36-45 pubmed publisher
    Twenty Staphylococcus aureus strains harboring seh gene, including one carrying also sec gene and 11 sea gene, were grown in BHI+YE broth and milk and were tested for SEA, SEC and SEH production...
  30. Li P, Tao W, Yang L, Shu Y. Effect of Soluble Epoxide Hydrolase in Hyperoxic Acute Lung Injury in Mice. Inflammation. 2018;41:1065-1072 pubmed publisher
    ..Inhibition of soluble epoxide hydrolase (sEH) has been reported to have protective effect on lipopolysaccharide-induced acute lung injury (ALI)...
  31. Wang Q, Pang W, Cui Z, Shi J, Liu Y, Liu B, et al. Upregulation of soluble epoxide hydrolase in proximal tubular cells mediated proteinuria-induced renal damage. Am J Physiol Renal Physiol. 2013;304:F168-76 pubmed publisher
    Epoxyeicosatrienoic acids, hydrolyzed by soluble epoxide hydrolase (sEH), have multiple biological functions, including the regulation of vascular tone, renal tubular transport, and being anti-inflammatory...
  32. Oguro A, Oida S, Imaoka S. Down-regulation of EPHX2 gene transcription by Sp1 under high-glucose conditions. Biochem J. 2015;470:281-91 pubmed publisher
    sEH (soluble epoxide hydrolase), which is encoded by the EPHX2 gene, regulates the actions of bioactive lipids, EETs (epoxyeicosatrienoic acids)...
  33. González Giraldo Y, Barreto G, Fava C, Forero D. Ischemic Stroke and Six Genetic Variants in CRP, EPHX2, FGA, and NOTCH3 Genes: A Meta-Analysis. J Stroke Cerebrovasc Dis. 2016;25:2284-9 pubmed publisher
    ..The main objective of this study was to carry out a meta-analysis for polymorphisms in CRP, EPHX2, FGA, and NOTCH3 genes and the risk for IS...
  34. Gao Y, Xu D, Zhao L, Sun Y. The DNA damage response of C. elegans affected by gravity sensing and radiosensitivity during the Shenzhou-8 spaceflight. Mutat Res. 2017;795:15-26 pubmed publisher
    ..Out of the 778 genes involved in DDR, except eya-1 and ceh-34, 28 altered genes in dys-1 mutant showed no predicted protein interactions, or anti-correlated miRNAs during ..
  35. Chen G, Xu R, Wang Y, Wang P, Zhao G, Xu X, et al. Genetic disruption of soluble epoxide hydrolase is protective against streptozotocin-induced diabetic nephropathy. Am J Physiol Endocrinol Metab. 2012;303:E563-75 pubmed publisher
    ..Genetic disruption of soluble epoxide hydrolase (sEH/EPHX2) results in increased EET levels through decreased hydrolysis...
  36. Scott Van Zeeland A, Bloss C, Tewhey R, Bansal V, Torkamani A, Libiger O, et al. Evidence for the role of EPHX2 gene variants in anorexia nervosa. Mol Psychiatry. 2014;19:724-32 pubmed publisher
    ..in the Estrogen Receptor-ß (ESR2) gene, as well as a set of rare and common variants in the Epoxide Hydrolase 2 (EPHX2) gene, in an initial sequencing study of 261 early-onset severe AN cases and 73 controls (P=0.0004)...
  37. Wadhwa P, Bagchi S, Sharma A. 3D-QSAR Selectivity Analysis of 1-Adamantyl-3-Heteroaryl Urea Analogs as Potent Inhibitors of Mycobacterium tuberculosis. Curr Comput Aided Drug Des. 2015;11:164-83 pubmed
    ..However, these analogs also exhibit affinity towards human soluble epoxide hydrolase (sEH) enzyme, making them pharmacologically undesirable...
  38. Parisi A, Caruso M, Normanno G, Latorre L, Sottili R, Miccolupo A, et al. Prevalence, antimicrobial susceptibility and molecular typing of Methicillin-Resistant Staphylococcus aureus (MRSA) in bulk tank milk from southern Italy. Food Microbiol. 2016;58:36-42 pubmed publisher
    ..All isolates were pvl-negative and icaA positive. The majority of strains (58%) carried the ses (sec, seh, seg, seo, sem and sen) genes...
  39. Wepler M, Beloiartsev A, Buswell M, Panigrahy D, Malhotra R, Buys E, et al. Soluble epoxide hydrolase deficiency or inhibition enhances murine hypoxic pulmonary vasoconstriction after lipopolysaccharide challenge. Am J Physiol Lung Cell Mol Physiol. 2016;311:L1213-L1221 pubmed publisher
    ..which are metabolized to less vasoactive dihydroxyeicosatrienoic acids (DHETs) by soluble epoxide hydrolase (sEH)...
  40. Islam O, Patil P, Goswami S, Razdan R, Inamdar M, Rizwan M, et al. Inhibitors of soluble epoxide hydrolase minimize ischemia-reperfusion-induced cardiac damage in normal, hypertensive, and diabetic rats. Cardiovasc Ther. 2017;35: pubmed publisher
    We designed a study to evaluate the cardioprotective effect of two soluble epoxide hydrolase (sEH) inhibitors, 1-(1-propanoylpiperidin-4-yl)-3-(4-trifluoromethoxy)phenyl)urea (TPPU) and trans-4-{4-[3-(4-trifluoromethoxyphenyl)-ureido]..
  41. Foreman M, Ma C, Hill A, Otten N, Sharma M, Tshabang N, et al. Dihydrobis(methimazolyl)borato complexes of ruthenium and osmium. Dalton Trans. 2017;46:14957-14972 pubmed publisher
    ..X = Cl, SePh), the latter reaction also providing traces of [Ru(SeH)(CO)(PPh3){κ2-H,S,S'-H2B(mt)2}]...
  42. Fairbanks S, Young J, Nelson J, Davis C, Koerner I, Alkayed N. Mechanism of the sex difference in neuronal ischemic cell death. Neuroscience. 2012;219:183-91 pubmed publisher
    ..EETs levels were determined by LC-MS/MS. Expression of sEH-encoding ephx2 was determined by qRT-PCR...
  43. Červenka L, Melenovský V, Husková Z, Sporková A, Bürgelová M, Škaroupková P, et al. Inhibition of soluble epoxide hydrolase does not improve the course of congestive heart failure and the development of renal dysfunction in rats with volume overload induced by aorto-caval fistula. Physiol Res. 2015;64:857-73 pubmed
    ..cyclohexyloxy]benzoic acid (c-AUCB, 3 mg/l in drinking water), an inhibitor of soluble epoxide hydrolase (sEH) which normally degrades EETs, increased intrarenal and myocardial EETs to levels observed in sham-operated HanSD ..
  44. Jaiswal K, Prashanth B, Ravi S, Shamasundar K, Singh S. Reactivity of a dihydroboron species: synthesis of a hydroborenium complex and an expedient entry into stable thioxo- and selenoxo-boranes. Dalton Trans. 2015;44:15779-85 pubmed publisher
    ..addition of S and Se into B-H bonds and subsequent release of H2S (or H2Se) from the intermediate LB(SH)2 (or LB(SeH)2) species forming stable compounds with terminal boron-chalcogen double bonds LB[double bond, length as m-dash]S ()..
  45. Thao N, Luyen B, Kim J, Jo A, Dat N, Kiem P, et al. Identification, characterization, kinetics, and molecular docking of flavonoid constituents from Archidendron clypearia (Jack.) Nielsen leaves and twigs. Bioorg Med Chem. 2016;24:3125-32 pubmed publisher
    In our search for natural soluble epoxide hydrolase (sEH) inhibitors from plants, we found that the methanolic extract of the leaves and twigs of Archidendron clypearia (Jack.) Nielsen (Fabaceae) significantly inhibits sEH in vitro...
  46. Basanisi M, La Bella G, Nobili G, Franconieri I, La Salandra G. Genotyping of methicillin-resistant Staphylococcus aureus (MRSA) isolated from milk and dairy products in South Italy. Food Microbiol. 2017;62:141-146 pubmed publisher
    ..carried one or more enterotoxin encoding genes (one strain had seg, sei, sem, sen and seo genes; two strains had seh gene). The 50% of isolated strains harboured PVL-encoding genes...
  47. Teunis M, Nagaraju M, Dutta P, Pu J, Muhoberac B, Sardar R, et al. Elucidating the role of surface passivating ligand structural parameters in hole wave function delocalization in semiconductor cluster molecules. Nanoscale. 2017;9:14127-14138 pubmed publisher
    ..carboxylate (-COO-), and amine (-NH2)], and binding head group [-SH, -SeH, and -TeH]...
  48. Teunissen F, Verbeek B, Cha T, Schwab J. Spinal cord injury after traumatic spine fracture in patients with ankylosing spinal disorders. J Neurosurg Spine. 2017;:1-8 pubmed publisher
    ..2%) and without (51.4%) SCI. A cervical fracture (odds ratio [OR] 2.70, p = 0.024) and a spinal epidural hematoma (SEH) after fracture (OR 2.69, p = 0.013) were predictive of SCI. Eleven patients (19...
  49. Mak S, Yu C, Sun W, He G, Liu X, Yang Q. Tetramethylpyrazine suppresses angiotensin II-induced soluble epoxide hydrolase expression in coronary endothelium via anti-ER stress mechanism. Toxicol Appl Pharmacol. 2017;336:84-93 pubmed publisher
    Activation of soluble epoxide hydrolase (sEH) is associated with endothelial dysfunction in hypertension, though the underlying mechanisms are inadequately understood and the role of endoplasmic reticulum (ER) stress is yet to be studied ..
  50. Althurwi H, Maayah Z, Elshenawy O, El Kadi A. Early Changes in Cytochrome P450s and Their Associated Arachidonic Acid Metabolites Play a Crucial Role in the Initiation of Cardiac Hypertrophy Induced by Isoproterenol. Drug Metab Dispos. 2015;43:1254-66 pubmed publisher
    ..Moreover, the role of P450 epoxygenases, ω-hydroxylases, and soluble epoxide hydrolase (sEH) were determined at mRNA, protein, and activity levels using real-time polymerase chain reaction, Western blot, and ..
  51. Sun Y, Kim J, Li W, Jo A, Yan X, Yang S, et al. Soluble epoxide hydrolase inhibitory activity of anthraquinone components from Aloe. Bioorg Med Chem. 2015;23:6659-65 pubmed publisher
    ..The inhibitory effects of the isolated compounds on soluble epoxide hydrolase (sEH) were evaluated. Compounds 1-8 inhibited sEH activity potently, with IC50 values ranging from 4.1±0.6 to 41...
  52. Tong X, Khandelwal A, Wu X, Xu Z, Yu W, Chen C, et al. Pro-atherogenic role of smooth muscle Nox4-based NADPH oxidase. J Mol Cell Cardiol. 2016;92:30-40 pubmed publisher
    ..Gene analysis indicated that soluble epoxide hydrolase 2 (sEH) was significantly downregulated in Nox4DN smooth muscle cells (SMC), at both mRNA and protein levels...
  53. Xue Y, Olsson T, Johansson C, Öster L, Beisel H, Rohman M, et al. Fragment Screening of Soluble Epoxide Hydrolase for Lead Generation-Structure-Based Hit Evaluation and Chemistry Exploration. ChemMedChem. 2016;11:497-508 pubmed publisher
    Soluble epoxide hydrolase (sEH) is involved in the regulation of many biological processes by metabolizing the key bioactive lipid mediator, epoxyeicosatrienoic acids...
  54. Farmahin R, Crump D, O Brien J, Jones S, Kennedy S. Time-dependent transcriptomic and biochemical responses of 6-formylindolo[3,2-b]carbazole (FICZ) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) are explained by AHR activation time. Biochem Pharmacol. 2016;115:134-43 pubmed publisher
    ..of the similarities and differences of the effects of FICZ and TCDD exposure in chicken embryo hepatocyte (CEH) cultures, we compared relative expression changes of 27 dioxin-responsive genes by the use of a chicken PCR array, ..
  55. El Sikhry H, Alsaleh N, Dakarapu R, Falck J, Seubert J. Novel Roles of Epoxyeicosanoids in Regulating Cardiac Mitochondria. PLoS ONE. 2016;11:e0160380 pubmed publisher
    ..analog UA-8 (13-(3-propylureido)tridec-8-enoic acid), possessing both EET-mimetic and soluble epoxide hydrolase (sEH) inhibitory properties, or 14,15-EET as model EET molecules...
  56. Romashko M, Schragenheim J, Abraham N, McClung J. Epoxyeicosatrienoic Acid as Therapy for Diabetic and Ischemic Cardiomyopathy. Trends Pharmacol Sci. 2016;37:945-962 pubmed publisher
    ..intervention, a promising strategy involves epoxyeicosatrienoic acid (EET) and soluble epoxide hydroxylase (sEH) inhibition...
  57. Yue C, Chen J, Hou R, Tian W, Liu K, Wang D, et al. The antioxidant action and mechanism of selenizing Schisandra chinensis polysaccharide in chicken embryo hepatocyte. Int J Biol Macromol. 2017;98:506-514 pubmed publisher
    ..mechanism of selenizing schisandra chinensis polysaccharide (sSCP) were investigated in chicken embryo hepatocyte (CEH) taking schisandra chinensis polysaccharide (SCP) and N-acetyl-L-cysteine (NAC) as control...
  58. Huang Y, Qin J, Sun D, Jiang H, Zheng L, He Y, et al. Inhibition of soluble epoxide hydrolase reduces portal pressure by protecting mesenteric artery myogenic responses in cirrhotic rats. Prostaglandins Other Lipid Mediat. 2017;131:17-24 pubmed publisher
    ..We investigated the effects of soluble epoxide hydrolase (sEH) inhibition on portal pressure and the myogenic response of mesenteric arteries isolated from cirrhotic rats using ..
  59. McHale Owen H, Bate C. Cholesterol ester hydrolase inhibitors reduce the production of synaptotoxic amyloid-? oligomers. Biochim Biophys Acta Mol Basis Dis. 2018;1864:649-659 pubmed publisher
    ..PAF activated cholesterol ester hydrolases (CEH), enzymes that released cholesterol from stores of cholesterol esters...
  60. Khanh P, Duc H, Huong T, Son N, Ha V, Van D, et al. Alkylphloroglucinol derivatives and triterpenoids with soluble epoxide hydrolase inhibitory activity from Callistemon citrinus. Fitoterapia. 2016;109:39-44 pubmed publisher
    ..All the isolated compounds were assessed for the effects on the sEH inhibitory activity...
  61. Blomfeldt A, Aamot H, Eskesen A, Monecke S, White R, Leegaard T, et al. DNA microarray analysis of Staphylococcus aureus causing bloodstream infection: bacterial genes associated with mortality?. Eur J Clin Microbiol Infect Dis. 2016;35:1285-95 pubmed publisher
    ..and elastic net regressions, we found evidence suggesting that agrIII and cna were positively and setC (=selX) and seh were negatively associated with S. aureus CC30 versus non-CC30 isolates...
  62. Karami L, Saboury A, Rezaee E, Tabatabai S. Investigation of the binding mode of 1, 3, 4-oxadiazole derivatives as amide-based inhibitors for soluble epoxide hydrolase (sEH) by molecular docking and MM-GBSA. Eur Biophys J. 2017;46:445-459 pubmed publisher
    The soluble epoxide hydrolase (sEH) enzyme plays an important role in the metabolism of endogenous chemical mediators involved in the regulation of blood pressure and inflammation...
  63. Deng W, Zhu Y, Lin J, Zheng L, Zhang C, Luo M. Inhibition of soluble epoxide hydrolase lowers portal hypertension in cirrhotic rats by ameliorating endothelial dysfunction and liver fibrosis. Prostaglandins Other Lipid Mediat. 2017;131:67-74 pubmed publisher
    ..acids (EETs) are arachidonic acid derived meditators which are catalyzed by soluble epoxide hydrolase (sEH) to less active dihydroeicostrienoics acids (DHETS)...
  64. Chang L, Lin H, Huang S, Chen I, Chu K, Chih C, et al. Blockade of soluble epoxide hydrolase attenuates post-ischemic neuronal hyperexcitation and confers resilience against stroke with TrkB activation. Sci Rep. 2018;8:118 pubmed publisher
    Inhibition and deletion of soluble epoxide hydrolase (sEH) has been suggested to ameliorate infarction in experimental ischemic stroke possibly via vasoactive epoxyeicosatrienoic acids...
  65. Fursova K, Shchannikova M, Loskutova I, Shepelyakovskaya A, Laman A, Boutanaev A, et al. Exotoxin diversity of Staphylococcus aureus isolated from milk of cows with subclinical mastitis in Central Russia. J Dairy Sci. 2018;101:4325-4331 pubmed publisher
    ..3%; seb, 3.3%; sec, 50%; sed, 4%; see, 46.6%; seg, 70%; sei, 10%; selp, 3.3%; and tsst1, 1.6%. The seh gene was not detected...
  66. McGee J, Fitzpatrick F. Enzymatic hydration of leukotriene A4. Purification and characterization of a novel epoxide hydrolase from human erythrocytes. J Biol Chem. 1985;260:12832-7 pubmed
    ..Human erythrocytes represent a novel source for an extrahepatic, cytosolic epoxide hydrolase with a potential physiological role. ..
  67. Zhang D, Ai D, Tanaka H, Hammock B, Zhu Y. DNA methylation of the promoter of soluble epoxide hydrolase silences its expression by an SP-1-dependent mechanism. Biochim Biophys Acta. 2010;1799:659-67 pubmed publisher
    ..They are hydrolyzed by soluble epoxide hydrolase (sEH)...
  68. Qin Y, Han X, Peng Y, Shen R, Guo X, Cao L, et al. Genetic variants in epoxide hydrolases modify the risk of oligozoospermia and asthenospermia in Han-Chinese population. Gene. 2012;510:171-4 pubmed publisher
    ..SNPstream and TaqMan assay were used to genotype four single nucleotide polymorphisms in EPHX1 and EPHX2. The semen analysis was performed by computer-assisted semen analysis system...
  69. Díaz Argelich N, Encio I, Plano D, Fernandes A, Palop J, Sanmartin C. Novel Methylselenoesters as Antiproliferative Agents. Molecules. 2017;22: pubmed publisher
    ..Importantly, the biological effects of Se compounds are exerted by their metabolites, with methylselenol (CH₃SeH) being one of the key executors...
  70. Kristoffersen E, Stavem K, Lundqvist C, Russell M. Excessive daytime sleepiness in secondary chronic headache from the general population. J Headache Pain. 2017;18:85 pubmed publisher
    ..A total of 47 participants had chronic post-traumatic headache (CPTH) and/or cervicogenic headache (CEH), 39 participants had headache attributed to chronic rhinosinusitis (HACRS), while 7 had other secondary headaches...
  71. Al Ajealy B, Al Shukri M, Al Jumaily H. Detection of newly defined superantigenic toxin genes and coagulase gene polymorphism in Staphylococcus aureus isolates. Rev Med Microbiol. 2017;28:158-163 pubmed publisher
    ..The most frequently encountered gene were sei (100.%), seh (5%), seg (65%). Many S...
  72. Santos J, Park J, Joiakim A, Putt D, Taylor R, Kim H. The role of soluble epoxide hydrolase in preeclampsia. Med Hypotheses. 2017;108:81-85 pubmed publisher
    ..EETs are converted to dihydroxyeicosatrienoic acids (DHETs) by the activity of soluble epoxide hydrolase (sEH)...
  73. Wixtrom R, Silva M, Hammock B. Cytosolic epoxide hydrolase in human placenta. Placenta. 1988;9:559-63 pubmed
    ..This cytosolic epoxide hydrolase was enriched more than 700-fold by affinity chromatography and appears similar to the enzyme from mouse and human liver in terms of molecular mass (Mr 59,000) and antigenic reactivity. ..
  74. Gschwendtner A, Ripke S, Freilinger T, Lichtner P, Muller Myhsok B, Wichmann H, et al. Genetic variation in soluble epoxide hydrolase (EPHX2) is associated with an increased risk of ischemic stroke in white Europeans. Stroke. 2008;39:1593-6 pubmed publisher
    Genetic variation in the EPHX2 gene region has been reported to influence susceptibility to ischemic stroke in blacks. We assessed the role of this gene region in white Europeans and performed analyses with regard to stroke subtypes...
  75. Lee S, Lee J, Cha R, Park M, Ha J, Kim S, et al. Genetic variations in soluble epoxide hydrolase and graft function in kidney transplantation. Transplant Proc. 2008;40:1353-6 pubmed publisher
    ..The aim of this study was to identify the association between genetic variations in soluble epoxide hydrolase (EPHX2, EET-metabolizing enzyme) and kidney allograft dysfunction...
  76. Liu Y, Zhang J, Yu L, Cao F, Rao J, Li J, et al. A soluble epoxide hydrolase inhibitor--8-HUDE increases pulmonary vasoconstriction through inhibition of K(ATP) channels. Pulm Pharmacol Ther. 2012;25:69-76 pubmed publisher
    ..of arachidonic acid, are endogenously produced epoxides that act as substrates for the soluble epoxide hydrolase (sEH)...
  77. Kitamura S, Morisseau C, Inceoglu B, Kamita S, De Nicola G, Nyegue M, et al. Potent natural soluble epoxide hydrolase inhibitors from Pentadiplandra brazzeana baillon: synthesis, quantification, and measurement of biological activities in vitro and in vivo. PLoS ONE. 2015;10:e0117438 pubmed publisher
    We describe here three urea-based soluble epoxide hydrolase (sEH) inhibitors from the root of the plant Pentadiplandra brazzeana...
  78. Tain Y, Lee W, Wu K, Leu S, Chan J. Targeting arachidonic acid pathway to prevent programmed hypertension in maternal fructose-fed male adult rat offspring. J Nutr Biochem. 2016;38:86-92 pubmed publisher
    ..We examined whether early treatment with a soluble epoxide hydrolase (SEH) inhibitor, 12-(3-adamantan-1-yl-ureido)-dodecanoic acid (AUDA) or 15-Deoxy-?12,14-prostagandin J2
  79. Padhy B, Hayat B, Nanda G, Mohanty P, Alone D. Pseudoexfoliation and Alzheimer's associated CLU risk variant, rs2279590, lies within an enhancer element and regulates CLU, EPHX2 and PTK2B gene expression. Hum Mol Genet. 2017;26:4519-4529 pubmed publisher
    ..a widespread enhancer effect on two nearby genes, protein tyrosine kinase 2 beta (PTK2B) and epoxide hydrolase-2 (EPHX2); both of which have been previously associated with AD as risk factors...
  80. Farin F, Janssen P, Quigley S, Abbott D, Hassett C, Smith Weller T, et al. Genetic polymorphisms of microsomal and soluble epoxide hydrolase and the risk of Parkinson's disease. Pharmacogenetics. 2001;11:703-8 pubmed
    ..The microsomal (EPHX1) and soluble (EPHX2) epoxide hydrolases function to regulate the oxidation status of a wide range of xenobiotic- and lipid-derived ..
  81. Polonikov A, Ivanov V, Solodilova M. Genetic variation of genes for xenobiotic-metabolizing enzymes and risk of bronchial asthma: the importance of gene-gene and gene-environment interactions for disease susceptibility. J Hum Genet. 2009;54:440-9 pubmed publisher
    ..The study results point to the potential relevance of toxicogenomic mechanisms of bronchial asthma in the modern world, and may thereby provide a novel direction in the genetic research of the respiratory disease in the future. ..
  82. Morisseau C, Schebb N, Dong H, Ulu A, Aronov P, Hammock B. Role of soluble epoxide hydrolase phosphatase activity in the metabolism of lysophosphatidic acids. Biochem Biophys Res Commun. 2012;419:796-800 pubmed publisher
    The EPXH2 gene encodes for the soluble epoxide hydrolase (sEH), which has two distinct enzyme activities: epoxide hydrolase (Cterm-EH) and phosphatase (Nterm-phos)...
  83. Bettaieb A, Nagata N, Aboubechara D, Chahed S, Morisseau C, Hammock B, et al. Soluble epoxide hydrolase deficiency or inhibition attenuates diet-induced endoplasmic reticulum stress in liver and adipose tissue. J Biol Chem. 2013;288:14189-99 pubmed publisher
    Soluble epoxide hydrolase (sEH) is a cytosolic enzyme whose inhibition has beneficial effects in cardiovascular, inflammatory, and metabolic diseases in murine models...
  84. Zhu X, Wang L, Wang Z, Chen S, Zhang W, Ma M. Relationship between EPHX2 gene polymorphisms and essential hypertension in Uygur, Kazakh, and Han. Genet Mol Res. 2015;14:3474-80 pubmed publisher
    We investigated the association between rs751141 polymorphisms in the EPHX2 gene and essential hypertension in Uygur, Kazakh, and Han subjects in Xinjiang, China...
  85. Gervasini G, García Cerrada M, Coto E, Vergara E, García Pino G, Alvarado R, et al. A 3'-UTR Polymorphism in Soluble Epoxide Hydrolase Gene Is Associated with Acute Rejection in Renal Transplant Recipients. PLoS ONE. 2015;10:e0133563 pubmed publisher
    ..to investigate whether the presence of functional polymorphisms in the gene encoding soluble epoxy hydrolase (EPHX2), which metabolizes EETs to less active compounds, may play a role in the outcome of renal transplantation...
  86. Klingler F, Wolf M, Wittmann S, Gribbon P, Proschak E. Bacterial Expression and HTS Assessment of Soluble Epoxide Hydrolase Phosphatase. J Biomol Screen. 2016;21:689-94 pubmed publisher
    Soluble epoxide hydrolase (sEH) is a bifunctional enzyme that possesses an epoxide hydrolase and lipid phosphatase activity (sEH-P) at two distinct catalytic domains...
  87. Khemiri M, Akrout Alhusain A, Abbassi M, El Ghaieb H, Santos Costa S, Belas A, et al. Clonal spread of methicillin-resistant Staphylococcus aureus-t6065-CC5-SCCmecV-agrII in a Libyan hospital. J Glob Antimicrob Resist. 2017;10:101-105 pubmed publisher
    ..eta: 25) and enterotxin genes (seb: 32, seo: 32, sei: 32, ser: 32, seu: 32, seg: 32, sej: 32, sed: 31, sen: 29, seh: 26, sec: 26, sea: 6, sek: 5), haemolysin (hla (32), hld (32), hlg (32)) and immune evasion cluster proteins (scn: ..
  88. Huang H, Wang Y, Lin H, Lee Y, Lin A. Soluble Epoxide Hydrolase Inhibition Attenuates MPTP-Induced Neurotoxicity in the Nigrostriatal Dopaminergic System: Involvement of ?-Synuclein Aggregation and ER Stress. Mol Neurobiol. 2018;55:138-144 pubmed publisher
    Soluble epoxide hydrolase (sEH) is widely expressed in the mammalian brain and possesses dual enzymatic activities, including C-terminal epoxide hydrolase (C-EH) which degrades epoxyeicosatrienoic acid (EET), a beneficial arachidonic ..
  89. Ricart P, Verma R, Fineberg S, Fink K, Lucas P, Lo Y, et al. Post-traumatic cervical spine epidural hematoma: Incidence and risk factors. Injury. 2017;48:2529-2533 pubmed publisher
    ..aim was to determine the incidence and associated risk factors for post-traumatic cervical spine epidural hematoma (SEH)...
  90. Kim H, Kim S, Kang K. Differential Effects of sEH Inhibitors on the Proliferation and Migration of Vascular Smooth Muscle Cells. Int J Mol Sci. 2017;18: pubmed publisher
    ..It is known that soluble epoxide hydrolase (sEH) is involved in the metabolic degradation of EET...
  91. Wang P, Meijer J, Guengerich F. Purification of human liver cytosolic epoxide hydrolase and comparison to the microsomal enzyme. Biochemistry. 1982;21:5769-76 pubmed
    ..The results provide evidence that physically different forms of epoxide hydrolase exist in different subcellular fractions and can have markedly different substrate specificities. ..
  92. Larsson C, White I, Johansson C, Stark A, Meijer J. Localization of the human soluble epoxide hydrolase gene (EPHX2) to chromosomal region 8p21-p12. Hum Genet. 1995;95:356-8 pubmed
    ..By fluorescence in situ hybridization to metaphase chromosomes, the soluble epoxide hydrolase gene was then localized to chromosomal region 8p21-p12. ..