EPHX1

Summary

Gene Symbol: EPHX1
Description: epoxide hydrolase 1
Alias: EPHX, EPOX, HYL1, MEH, epoxide hydrolase 1, epoxide hydratase, epoxide hydrolase 1 microsomal, epoxide hydrolase 1, microsomal (xenobiotic)
Species: human
Products:     EPHX1

Top Publications

  1. Casson A, Zheng Z, Chiasson D, MacDonald K, Riddell D, Guernsey J, et al. Associations between genetic polymorphisms of Phase I and II metabolizing enzymes, p53 and susceptibility to esophageal adenocarcinoma. Cancer Detect Prev. 2003;27:139-46 pubmed
    ..assays (RFLP/SSCP) were used to genotype cytochrome P450 (CYP) 1A1 [MspI; Ile:Val], microsomal epoxide hydroxylase (mEH) (fast and slow alleles), and glutathione S-transferase (GST) T1, M1 and P1...
  2. Voho A, Metsola K, Anttila S, Impivaara O, Järvisalo J, Vainio H, et al. EPHX1 gene polymorphisms and individual susceptibility to lung cancer. Cancer Lett. 2006;237:102-8 pubmed
    We investigated the roles of EPHX1 Tyr113His and His139Arg polymorphisms in lung cancer susceptibility in a Finnish study population comprising of 230 lung cancer cases and a large control group (n=2105)...
  3. Khedhaier A, Hassen E, Bouaouina N, Gabbouj S, Ahmed S, Chouchane L. Implication of Xenobiotic Metabolizing Enzyme gene (CYP2E1, CYP2C19, CYP2D6, mEH and NAT2) polymorphisms in breast carcinoma. BMC Cancer. 2008;8:109 pubmed publisher
    ..This study investigated the susceptibility and prognostic implications of the CYP2E1, CYP2C19, CYP2D6, mEH and NAT2 gene polymorphisms in breast carcinoma patients...
  4. Kiss I, Orsos Z, Gombos K, Bogner B, Csejtei A, Tibold A, et al. Association between allelic polymorphisms of metabolizing enzymes (CYP 1A1, CYP 1A2, CYP 2E1, mEH) and occurrence of colorectal cancer in Hungary. Anticancer Res. 2007;27:2931-7 pubmed
    ..genotyped for cytochrome P450 enzymes (CYP) 1A1 Ile/Val, CYP 1A2*1F, CYP 2E1 c1/c2, microsomal epoxy hydrolase (mEH) exon 3 Tyr113His and exon 4 His139Arg polymorphisms by allele-specific polymerase chain reaction (PCR) or PCR-..
  5. Silveira V, Canalle R, Scrideli C, Queiroz R, Tone L. Role of the CYP2D6, EPHX1, MPO, and NQO1 genes in the susceptibility to acute lymphoblastic leukemia in Brazilian children. Environ Mol Mutagen. 2010;51:48-56 pubmed publisher
    ..study was to evaluate the effect of the polymorphisms of debrisoquine hydroxylase (CYP2D6), epoxide hydrolase (EPHX1), myeloperoxidase (MPO), and quinone-oxoreductase (NQO1), which have been implicated in xenobiotic metabolism, on ..
  6. Lebailly P, Willett E, Moorman A, Roman E, Cartwright R, Morgan G, et al. Genetic polymorphisms in microsomal epoxide hydrolase and susceptibility to adult acute myeloid leukaemia with defined cytogenetic abnormalities. Br J Haematol. 2002;116:587-94 pubmed
    ..We tested the hypothesis that smoking as well as genetic polymorphisms in the microsomal epoxide hydrolase gene (HYL1), an enzyme involved in benzene metabolism, could be risk factors for AML with defined chromosomal abnormalities...
  7. Kirk G, Turner P, Gong Y, Lesi O, Mendy M, Goedert J, et al. Hepatocellular carcinoma and polymorphisms in carcinogen-metabolizing and DNA repair enzymes in a population with aflatoxin exposure and hepatitis B virus endemicity. Cancer Epidemiol Biomarkers Prev. 2005;14:373-9 pubmed
    ..We investigated genetic polymorphisms in carcinogen-metabolizing (GSTM1, GSTT1, HYL1*2) and DNA repair (XRCC1) enzymes in a hospital-based case-control study...
  8. Hang J, Zhou W, Wang X, Zhang H, Sun B, Dai H, et al. Microsomal epoxide hydrolase, endotoxin, and lung function decline in cotton textile workers. Am J Respir Crit Care Med. 2005;171:165-70 pubmed
    Occupational exposure to endotoxin in organic dust may induce lung function decline. Microsomal epoxide hydrolase (mEH) detoxifies reactive oxygen species generated by endotoxin exposure, and polymorphisms of the mEH gene are associated ..
  9. Turner F, Smith G, Sachse C, Lightfoot T, Garner R, Wolf C, et al. Vegetable, fruit and meat consumption and potential risk modifying genes in relation to colorectal cancer. Int J Cancer. 2004;112:259-64 pubmed
    ..was conducted in the United Kingdom to investigate whether 6 such genes (CYP1A1, GSTT1, GSTM1, GSTP1, EPHX1 and NQO1) modify the relationship between diet and disease risk...

More Information

Publications105 found, 100 shown here

  1. Coller J, Fritz P, Zanger U, Siegle I, Eichelbaum M, Kroemer H, et al. Distribution of microsomal epoxide hydrolase in humans: an immunohistochemical study in normal tissues, and benign and malignant tumours. Histochem J. 2001;33:329-36 pubmed
    ..Nonetheless, immunohistochemical identification of microsomal epoxide hydrolase may be helpful in some well-defined histological settings, for example, confirmation of hepatocellular carcinoma. ..
  2. Buschini A, De Palma G, Poli P, Martino A, Rossi C, Mozzoni P, et al. Genetic polymorphism of drug-metabolizing enzymes and styrene-induced DNA damage. Environ Mol Mutagen. 2003;41:243-52 pubmed
    ..in glutathione S-transferase genes (GSTM1, GSTT1, GSTP1) and the gene encoding microsomal epoxide hydrolase (EPHX) were characterized to assess their possible modifying role in styrene metabolism and subsequent DNA damage...
  3. Chan S, Thalamuthu A, Goh B, Chia K, Chuah B, Wong A, et al. Exon sequencing and association analysis of EPHX1 genetic variants with maintenance warfarin dose in a multiethnic Asian population. Pharmacogenet Genomics. 2011;21:35-41 pubmed
    ..Several studies have found signals of association with warfarin maintenance dose in the EPHX1 gene...
  4. Sarmanova J, Tynková L, Susova S, Gut I, Soucek P. Genetic polymorphisms of biotransformation enzymes: allele frequencies in the population of the Czech Republic. Pharmacogenetics. 2000;10:781-8 pubmed
    ..determine the frequency of polymorphisms in CYP1A1 (3'-flanking region), CYP2E1 (5'-flanking region and intron 6), EPHX (exon 3 and exon 4), GSTM1 (deletion), GSTP1 (exon 5) and GSTT1 (deletion) in a group of 416 Czech individuals...
  5. Sarmanová J, Susova S, Gut I, Mrhalova M, Kodet R, Adámek J, et al. Breast cancer: role of polymorphisms in biotransformation enzymes. Eur J Hum Genet. 2004;12:848-54 pubmed
    We aimed at determining whether any association exists between genetic polymorphisms in epoxide hydrolase (EPHX1), NADPH-quinone oxidoreductase (NQO1), glutathione S-transferases (GSTM1/P1/T1) and individual susceptibility to breast ..
  6. Sahin O, Arikan S, Oltulu Y, Coskunpinar E, Eren A, Cacina C, et al. Investigation of a possible relationship between EPHX1 gene polymorphisms and colorectal cancer in Turkish society. Genet Test Mol Biomarkers. 2012;16:423-8 pubmed publisher
    ..Microsomal epoxide hydrolase (EPHX1) has an important role in the metabolism of polycyclic aromatic hydrocarbons and detoxification of procarcinogens...
  7. Yin L, Pu Y, Liu T, Tung Y, Chen K, Lin P. Genetic polymorphisms of NAD(P)H quinone oxidoreductase, CYP1A1 and microsomal epoxide hydrolase and lung cancer risk in Nanjing, China. Lung Cancer. 2001;33:133-41 pubmed
    ..of NAD(P)H quinone oxidoreductase (NQO1), cytochrome P4501A1 (CYP1A1) and microsomal epoxide hydrolase (HYL1) have been associated with increased lung cancer risk in Asian populations...
  8. da Silva Silveira V, Canalle R, Scrideli C, Queiroz R, Bettiol H, Valera E, et al. Polymorphisms of xenobiotic metabolizing enzymes and DNA repair genes and outcome in childhood acute lymphoblastic leukemia. Leuk Res. 2009;33:898-901 pubmed publisher
    ..We investigated whether ALL outcome was related to polymorphisms in genes CYP2D6, MPO, EPHX1, NQO1, TS, XPD and XRCC1 in 95 consecutive ALL children by PCR or PCR-FRLP techniques...
  9. Cotterchio M, Boucher B, Manno M, Gallinger S, Okey A, Harper P. Red meat intake, doneness, polymorphisms in genes that encode carcinogen-metabolizing enzymes, and colorectal cancer risk. Cancer Epidemiol Biomarkers Prev. 2008;17:3098-107 pubmed publisher
    ..in overcooked meat (cytochrome P450, glutathione S-transferase, UDP-glucuronosyltransferases, SULT, NAT, mEH, and AHR). CYP2C9 and NAT2 variants were associated with colorectal cancer risk...
  10. Goode E, White K, Vierkant R, Phelan C, Cunningham J, Schildkraut J, et al. Xenobiotic-Metabolizing gene polymorphisms and ovarian cancer risk. Mol Carcinog. 2011;50:397-402 pubmed publisher
    ..including 956 of serous sub-type) and controls (N?=?2046) from three studies were genotyped at 11 SNPs in EPHX1, ADH4, ADH1A, NQO2, NAT2, GSTP1, CYP1A1, and NQO1, following an initial SNP screen in a subset of participants...
  11. McGlynn K, Rosvold E, Lustbader E, Hu Y, Clapper M, Zhou T, et al. Susceptibility to hepatocellular carcinoma is associated with genetic variation in the enzymatic detoxification of aflatoxin B1. Proc Natl Acad Sci U S A. 1995;92:2384-7 pubmed
    ..To test this hypothesis, genetic variation in two AFB1 detoxification genes, epoxide hydrolase (EPHX) and glutathione S-transferase M1 (GSTM1), was contrasted with the presence of serum AFB1-albumin adducts, the ..
  12. Hersh C, DeMeo D, Lazarus R, Celedon J, Raby B, Benditt J, et al. Genetic association analysis of functional impairment in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2006;173:977-84 pubmed
    ..The test-replication approach identified four genes-microsomal epoxide hydrolase (EPHX1), latent transforming growth factor-beta binding protein-4 (LTBP4), surfactant protein B (SFTPB), and transforming ..
  13. Zienolddiny S, Campa D, Lind H, Ryberg D, Skaug V, Stangeland L, et al. A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of non-small cell lung cancer in smokers. Carcinogenesis. 2008;29:1164-9 pubmed publisher
    ..Moreover, significant associations with multiple SNPs in the phase II genes ALDH2, COMT, EPHX1, SOD2, NAT1, NAT2, GSTM3, GSTP1, GSTT2 and MPO were also found...
  14. Northwood E, Elliott F, Forman D, Barrett J, Wilkie M, Carey F, et al. Polymorphisms in xenobiotic metabolizing enzymes and diet influence colorectal adenoma risk. Pharmacogenet Genomics. 2010;20:315-26 pubmed publisher
    ..glutathione S-transferase (GST), N-acetyl transferase, quinone reductase (NQ01) and microsomal epoxide hydrolase (EPHX1) genes] were genotyped using multiplex PCR or Taqman-based allelic discrimination assays and analyzed in ..
  15. Gsur A, Zidek T, Schnattinger K, Feik E, Haidinger G, Hollaus P, et al. Association of microsomal epoxide hydrolase polymorphisms and lung cancer risk. Br J Cancer. 2003;89:702-6 pubmed
    Microsomal epoxide hydrolase (mEH) plays a dual role in the detoxification and activation of tobacco procarcinogens...
  16. Ockenga J, Strunck S, Post C, Schulz H, Halangk J, Pfutzer R, et al. The role of epoxide hydrolase Y113H gene variant in pancreatic diseases. Pancreas. 2009;38:e97-e101 pubmed publisher
    ..Microsomal epoxide hydrolase (EPHX1) is a phase II detoxifying enzyme capable of tobacco-borne toxicant inactivation...
  17. Tumer T, Sahin G, Arinç E. Association between polymorphisms of EPHX1 and XRCC1 genes and the risk of childhood acute lymphoblastic leukemia. Arch Toxicol. 2012;86:431-9 pubmed publisher
    Microsomal epoxide hydrolase, EPHX1, plays a central role in the detoxification of potentially genotoxic epoxide intermediates...
  18. Hattori N, Fujiwara H, Maeda M, Fujii S, Ueda M. Epoxide hydrolase affects estrogen production in the human ovary. Endocrinology. 2000;141:3353-65 pubmed
    ..acids of the 46-kDa protein from porcine liver exhibited high homology (82%) to human microsomal epoxide hydrolase (mEH)...
  19. Sarmanova J, Benesova K, Gut I, Nedelcheva Kristensen V, Tynková L, Soucek P. Genetic polymorphisms of biotransformation enzymes in patients with Hodgkin's and non-Hodgkin's lymphomas. Hum Mol Genet. 2001;10:1265-73 pubmed
    ..at determining whether any association exists between genetic polymorphisms in CYP1A1, CYP2E1, epoxide hydrolase (EPHX), glutathione S-transferases (GSTM1/P1/T1) and individual susceptibility to lymphomas...
  20. Amador A, Righi P, Radpour S, Everett E, Weisberger E, Langer M, et al. Polymorphisms of xenobiotic metabolizing genes in oropharyngeal carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002;93:440-5 pubmed
    The objective was to determine the prevalence of the polymorphisms of the microsomal epoxide hydrolase (Ephx1), glutathione S-transferase mu1 (GSTM ), theta1 (GSTT1), and pi1 (GSTP1) genes in patients with oropharyngeal carcinoma...
  21. Park J, Schantz S, Lazarus P. Epoxide hydrolase genotype and orolaryngeal cancer risk: interaction with GSTM1 genotype. Oral Oncol. 2003;39:483-90 pubmed
    ..5, 95% CI=1.3-9.3) but not GSTM [+] (OR=0.9, 95%CI=0.4-2.1) genotype. These results suggest that EH polymorphisms play an important role in risk for orolaryngeal cancer in Caucasians. ..
  22. Cajas Salazar N, Au W, Zwischenberger J, Sierra Torres C, Salama S, Alpard S, et al. Effect of epoxide hydrolase polymorphisms on chromosome aberrations and risk for lung cancer. Cancer Genet Cytogenet. 2003;145:97-102 pubmed
    Microsomal epoxide hydrolase (mEH) gene is polymorphic and its enzyme is involved in the activation and subsequent detoxification of several tobacco carcinogens, for example polycyclic aromatic hydrocarbons...
  23. Kiran M, Chawla Y, Kaur J. Glutathione-S-transferase and microsomal epoxide hydrolase polymorphism and viral-related hepatocellular carcinoma risk in India. DNA Cell Biol. 2008;27:687-94 pubmed publisher
    ..GST and mEPHX variants share a positive association with viral-related HCC risk in Indian population, although a larger sample size is still required to confirm the results. ..
  24. Sangrajrang S, Sato Y, Sakamoto H, Ohnami S, Laird N, Khuhaprema T, et al. Genetic polymorphisms of estrogen metabolizing enzyme and breast cancer risk in Thai women. Int J Cancer. 2009;125:837-43 pubmed publisher
    ..SNPs) in the CYP1A1, CYP1A2, CYP1B1, CYP17, CYP19, CYP2C9, CYP2C19, AhR, ESR1, PGR, ERRG, COMT, HSD17B1, HSD17B2, EPHX1 and NQO1 genes were genotyped...
  25. Zhao H, Spitz M, Gwyn K, Wu X. Microsomal epoxide hydrolase polymorphisms and lung cancer risk in non-Hispanic whites. Mol Carcinog. 2002;33:99-104 pubmed
    ..72 (95% CI=0.90-3.29). This elevated risk was also evident only in younger people. These findings suggest that these variant alleles of exon 3 and exon 4 of mEPHX modulates lung cancer risk. ..
  26. Brøgger J, Steen V, Eiken H, Gulsvik A, Bakke P. Genetic association between COPD and polymorphisms in TNF, ADRB2 and EPHX1. Eur Respir J. 2006;27:682-8 pubmed
    ..of 16 studies, involving seven polymorphisms in three well-studied genes: microsomal epoxide hydroxylase (EPHX1); tumour necrosis factor; and beta2-adrenoreceptor...
  27. Tranah G, Chan A, Giovannucci E, Ma J, Fuchs C, Hunter D. Epoxide hydrolase and CYP2C9 polymorphisms, cigarette smoking, and risk of colorectal carcinoma in the Nurses' Health Study and the Physicians' Health Study. Mol Carcinog. 2005;44:21-30 pubmed
    Microsomal epoxide hydrolase (mEH) and cytochrome P450 2C9 (CYP2C9) are involved in the bioactivation and detoxification of polycyclic aromatic hydrocarbons (PAHs) derived from tobacco smoke...
  28. Figueroa J, Malats N, Garcia Closas M, Real F, Silverman D, Kogevinas M, et al. Bladder cancer risk and genetic variation in AKR1C3 and other metabolizing genes. Carcinogenesis. 2008;29:1955-62 pubmed publisher
    ..nuclear translocator (ARNT)] and genes that activate/detoxify AA or PAH (AKR1C3, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EPHX1, EPHX2, NQO1, MPO, UGT1A4, SULT1A1 and SULT1A2)...
  29. Loebstein R, Vecsler M, Kurnik D, Austerweil N, Gak E, Halkin H, et al. Common genetic variants of microsomal epoxide hydrolase affect warfarin dose requirements beyond the effect of cytochrome P450 2C9. Clin Pharmacol Ther. 2005;77:365-72 pubmed
    ..We examined the influence on warfarin dose requirements of candidate genes encoding microsomal epoxide hydrolase (mEH), as well as glutathione S -transferase A1 (GSTA1) components of vitamin K epoxide reductase and the gamma-..
  30. Kiyohara C, Yoshimasu K, Takayama K, Nakanishi Y. EPHX1 polymorphisms and the risk of lung cancer: a HuGE review. Epidemiology. 2006;17:89-99 pubmed
    Microsomal epoxide hydrolase 1 (EPHX1) plays an important role in both the activation and detoxification of tobacco-derived carcinogens...
  31. Boccia S, Sayed Tabatabaei F, Persiani R, Gianfagna F, Rausei S, Arzani D, et al. Polymorphisms in metabolic genes, their combination and interaction with tobacco smoke and alcohol consumption and risk of gastric cancer: a case-control study in an Italian population. BMC Cancer. 2007;7:206 pubmed
    ..Haplotype analysis was performed for EPHX1 exons 3 and 4, as well as CYP2E1 RsaI (*5 alleles) and CYP2E1 DraI (*5A or *6 alleles)...
  32. Gu Q, Kong Y, Schneede J, Xiao Y, Chen L, Zhong Q, et al. VKORC1-1639G>A, CYP2C9, EPHX1691A>G genotype, body weight, and age are important predictors for warfarin maintenance doses in patients with mechanical heart valve prostheses in southwest China. Eur J Clin Pharmacol. 2010;66:1217-27 pubmed publisher
    ..8% of the total variation (adjusted R (2) of 0.743) in warfarin maintenance doses in southwest Chinese patients with mechanical heart valve prostheses. ..
  33. Foreman M, DeMeo D, Hersh C, Carey V, Fan V, Reilly J, et al. Polymorphic variation in surfactant protein B is associated with COPD exacerbations. Eur Respir J. 2008;32:938-44 pubmed publisher
    ..A total of 88 single nucleotide polymorphisms (SNPs) in the genes microsomal epoxide hydrolase (EPHX1), transforming growth factor, beta-1 (TGFB1), serpin peptidase inhibitor, clade E (nexin, plasminogen activator ..
  34. Mitrou P, Watson M, Loktionov A, Cardwell C, Gunter M, Atkin W, et al. Role of NQO1C609T and EPHX1 gene polymorphisms in the association of smoking and alcohol with sporadic distal colorectal adenomas: results from the UKFSS Study. Carcinogenesis. 2007;28:875-82 pubmed
    NADP(H):quinone oxidoreductase 1 (NQO1) and microsomal epoxide hydrolase (EPHX1, also mEH) are attractive candidate enzymes for association with colorectal neoplasia because they metabolize a number of compounds including polycyclic ..
  35. Srivastava D, Mandhani A, Mittal R. Genetic polymorphisms of cytochrome P450 CYP1A1 (*2A) and microsomal epoxide hydrolase gene, interactions with tobacco-users, and susceptibility to bladder cancer: a study from North India. Arch Toxicol. 2008;82:633-9 pubmed publisher
    ..e., microsomal epoxide hydrolase: mEH) is mainly involved in the detoxification of wide variety of endogenous or exogenous carcinogens...
  36. de Assis S, Ambrosone C, Wustrack S, Krishnan S, Freudenheim J, Shields P. Microsomal epoxide hydrolase variants are not associated with risk of breast cancer. Cancer Epidemiol Biomarkers Prev. 2002;11:1697-8 pubmed
  37. Huang W, Chatterjee N, Chanock S, Dean M, Yeager M, Schoen R, et al. Microsomal epoxide hydrolase polymorphisms and risk for advanced colorectal adenoma. Cancer Epidemiol Biomarkers Prev. 2005;14:152-7 pubmed
    ..Microsomal epoxide hydrolase (EPHX1) metabolizes polycyclic aromatic hydrocarbons, carcinogens found in cigarette smoke...
  38. Lin Y, Wu D, Lee J, Hsu H, Kao E, Yang C, et al. The association between microsomal epoxide hydrolase genotypes and esophageal squamous-cell-carcinoma in Taiwan: interaction between areca chewing and smoking. Cancer Lett. 2006;237:281-8 pubmed
    ..to determine the association between esophageal squamous-cell-carcinoma (ESCC) and microsomal epoxide hydrolase (mEH) genotypes at Thy113His and His139Arg...
  39. De Roos A, Gold L, Wang S, Hartge P, Cerhan J, Cozen W, et al. Metabolic gene variants and risk of non-Hodgkin's lymphoma. Cancer Epidemiol Biomarkers Prev. 2006;15:1647-53 pubmed
    ..between non-Hodgkin's lymphoma and 15 variants in AHR, CYP1A1, CYP1A2, CYP1B1, CYP2C9, CYP2E1, GSTP1, GSTM3, EPHX1, NQO1, and PON1...
  40. DeMeo D, Hersh C, Hoffman E, Litonjua A, Lazarus R, Sparrow D, et al. Genetic determinants of emphysema distribution in the national emphysema treatment trial. Am J Respir Crit Care Med. 2007;176:42-8 pubmed
    ..GSTP1, EPHX1, and MMP1 polymorphisms were associated with the densitometric, apical-predominant distribution of emphysema (p ..
  41. Boccia S, Cadoni G, Sayed Tabatabaei F, Volante M, Arzani D, De Lauretis A, et al. CYP1A1, CYP2E1, GSTM1, GSTT1, EPHX1 exons 3 and 4, and NAT2 polymorphisms, smoking, consumption of alcohol and fruit and vegetables and risk of head and neck cancer. J Cancer Res Clin Oncol. 2008;134:93-100 pubmed
    ..of 210 cases and 245 hospital controls, age and gender matched, were genotyped for CYP1A1, CYP2E1, GSTM1, GSTT1, EPHX1 exons 3 and 4, and NAT2 polymorphisms...
  42. Lacko M, Roelofs H, Te Morsche R, Voogd A, Oude Ophuis M, Peters W, et al. Microsomal epoxide hydrolase genotypes and the risk for head and neck cancer. Head Neck. 2008;30:836-44 pubmed publisher
    Microsomal epoxide hydrolase (mEH) is an enzyme involved in the metabolism of (pre)carcinogens in tobacco smoke...
  43. Pautas E, Moreau C, Gouin Thibault I, Golmard J, Mahe I, Legendre C, et al. Genetic factors (VKORC1, CYP2C9, EPHX1, and CYP4F2) are predictor variables for warfarin response in very elderly, frail inpatients. Clin Pharmacol Ther. 2010;87:57-64 pubmed publisher
    ..7 +/- 6 years. In addition to age, genetic variants of VKORC1, CYP2C9, CYP4F2, and EPHX1 were found to be significant predictor variables for the maintenance dose of warfarin, explaining 26...
  44. Timofeeva M, Kropp S, Sauter W, Beckmann L, Rosenberger A, Illig T, et al. Genetic polymorphisms of MPO, GSTT1, GSTM1, GSTP1, EPHX1 and NQO1 as risk factors of early-onset lung cancer. Int J Cancer. 2010;127:1547-61 pubmed publisher
    ..A case-control study was conducted to investigate the effects of genetic polymorphisms in the MPO, EPHX1, GSTT1, GSTM1, GSTP1 and NQO1 genes on the risk of early-onset lung cancer development...
  45. Hassett C, Aicher L, Sidhu J, Omiecinski C. Human microsomal epoxide hydrolase: genetic polymorphism and functional expression in vitro of amino acid variants. Hum Mol Genet. 1994;3:421-8 pubmed
    Human microsomal epoxide hydrolase (mEH) is a biotransformation enzyme that metabolizes reactive epoxide intermediates to more water-soluble trans-dihydrodiol derivatives...
  46. Ulrich C, Bigler J, Whitton J, Bostick R, Fosdick L, Potter J. Epoxide hydrolase Tyr113His polymorphism is associated with elevated risk of colorectal polyps in the presence of smoking and high meat intake. Cancer Epidemiol Biomarkers Prev. 2001;10:875-82 pubmed
    Microsomal epoxide hydrolase (mEH) metabolizes polycyclic aromatic hydrocarbons, carcinogens found in cigarette smoke and cooked meat. Polymorphisms in exon 3 and exon 4 of the mEH gene have been found to alter mEH activity...
  47. Sonzogni L, Silvestri L, De Silvestri A, Gritti C, Foti L, Zavaglia C, et al. Polymorphisms of microsomal epoxide hydrolase gene and severity of HCV-related liver disease. Hepatology. 2002;36:195-201 pubmed
    ..We investigated the association of liver disease severity with common alleles of microsomal epoxide hydrolase (mEH), an enzyme involved in the metabolism of highly reactive epoxide intermediates...
  48. De Roos A, Rothman N, Brown M, Bell D, Pittman G, Shapiro W, et al. Variation in genes relevant to aromatic hydrocarbon metabolism and the risk of adult brain tumors. Neuro Oncol. 2006;8:145-55 pubmed
    ..We evaluated associations between gene variants in CYP1A1, CYP1B1, GSTM3, EPHX1, and NQO1 and adult brain tumor incidence...
  49. Agudo A, Sala N, Pera G, Capella G, Berenguer A, Garcia N, et al. Polymorphisms in metabolic genes related to tobacco smoke and the risk of gastric cancer in the European prospective investigation into cancer and nutrition. Cancer Epidemiol Biomarkers Prev. 2006;15:2427-34 pubmed
    ..study looking at the association between risk of gastric adenocarcinoma and polymorphisms in genes CYP1A1, CYP1A2, EPHX1, and GSTT1...
  50. Justenhoven C, Hamann U, Schubert F, Zapatka M, Pierl C, Rabstein S, et al. Breast cancer: a candidate gene approach across the estrogen metabolic pathway. Breast Cancer Res Treat. 2008;108:137-49 pubmed
    ..Of these CYP17A1, CYP19A1, EPHX1, HSD17B1, SRD5A2, and PPARG2 participate in biosynthesis, CYP1A1, CYP1B1, COMT, GSTP1, and SOD2 in catabolism and ..
  51. Rosenberger A, Illig T, Korb K, Klopp N, Zietemann V, Wölke G, et al. Do genetic factors protect for early onset lung cancer? A case control study before the age of 50 years. BMC Cancer. 2008;8:60 pubmed publisher
    ..Genetic associations or gene-smoking interactions was found for GPX1(Pro200Leu) and EPHX1(His113Tyr). Carriers of the Leu-allele of GPX1(Pro200Leu) showed a significant risk reduction of OR = 0...
  52. Li X, Hu Z, Qu X, Zhu J, Li L, Ring B, et al. Putative EPHX1 enzyme activity is related with risk of lung and upper aerodigestive tract cancers: a comprehensive meta-analysis. PLoS ONE. 2011;6:e14749 pubmed publisher
    b>EPHX1 is a key enzyme in metabolizing some exogenous carcinogens such as products of cigarette-smoking...
  53. Chen C, Wang R, Lee C, Lin C, Chang H, Hsiue T. Polymorphism of microsomal epoxide hydrolase is associated with chronic obstructive pulmonary disease and bronchodilator response. J Formos Med Assoc. 2011;110:685-9 pubmed publisher
    ..This was a hospital-based case-control study. The EPHX1 genetic mutations of 105 smokers with COPD and 103 control smokers without COPD were evaluated by polymerase chain ..
  54. To Figueras J, Gene M, Gomez Catalan J, Pique E, Borrego N, Corbella J. Lung cancer susceptibility in relation to combined polymorphisms of microsomal epoxide hydrolase and glutathione S-transferase P1. Cancer Lett. 2001;173:155-62 pubmed
    ..Two polymorphisms have been described in the coding region of the mEH gene (EPHX1) that produce two protein variants: 113Tyr-->113His (exon 3) and 139His-->139Arg (exon 4)...
  55. Kuljukka Rabb T, Nylund L, Vaaranrinta R, Savela K, Mutanen P, Veidebaum T, et al. The effect of relevant genotypes on PAH exposure-related biomarkers. J Expo Anal Environ Epidemiol. 2002;12:81-91 pubmed
    ..Urinary mutagenicity was measured using the Ames test. CYP1A1, microsomal epoxide hydrolase (mEH), and glutathione S-transferase (GST) genotypes were analyzed by polymerase chain reaction (PCR)...
  56. Lee W, Brennan P, Boffetta P, London S, Benhamou S, Rannug A, et al. Microsomal epoxide hydrolase polymorphisms and lung cancer risk: a quantitative review. Biomarkers. 2002;7:230-41 pubmed
    To investigate the role of microsomal epoxide hydrolase (mEH) polymorphisms in the aetiology of lung cancer and to assess the interaction between mEH polymorphisms and smoking, we performed a meta-analysis of seven published studies, ..
  57. Sierra Torres C, Au W, Arrastia C, Cajas Salazar N, Robazetti S, Payne D, et al. Polymorphisms for chemical metabolizing genes and risk for cervical neoplasia. Environ Mol Mutagen. 2003;41:69-76 pubmed
    ..exposure to cigarette smoke and inheritance of polymorphic chemical metabolizing genes (CYP2E1, GSTM1, and mEH) significantly increase the risk for neoplasia...
  58. Hosagrahara V, Rettie A, Hassett C, Omiecinski C. Functional analysis of human microsomal epoxide hydrolase genetic variants. Chem Biol Interact. 2004;150:149-59 pubmed
    Human microsomal epoxide hydrolase (EPHX1) is active in the metabolism of many potentially carcinogenic or otherwise genotoxic epoxides, such as those derived from the oxidation of polyaromatic hydrocarbons...
  59. Sanderson S, Emery J, Higgins J. CYP2C9 gene variants, drug dose, and bleeding risk in warfarin-treated patients: a HuGEnet systematic review and meta-analysis. Genet Med. 2005;7:97-104 pubmed
    ..Testing for gene variants could potentially alter clinical management in patients commencing warfarin. Evidence for the clinical utility and cost-effectiveness of genotyping is needed before routine testing can be recommended. ..
  60. Kiran M, Chawla Y, Jain M, Kaur J. Haplotypes of microsomal epoxide hydrolase and x-ray cross-complementing group 1 genes in Indian hepatocellular carcinoma patients. DNA Cell Biol. 2009;28:573-7 pubmed publisher
    ..Arg-His-Arg haplotype of XRCC1 significantly enhanced the risk for hepatitis by 2.8-folds (p = 0.001), but not for HCC (odds ratio = 1.5; p = 0.28). mEPHX haplotypes shared a positive association with HCC risk in India. ..
  61. Dura P, Bregitha C, Te Morsche R, Roelofs H, Kristinsson J, Wobbes T, et al. EPHX1 polymorphisms do not modify esophageal carcinoma susceptibility in Dutch Caucasians. Oncol Rep. 2012;27:1710-6 pubmed publisher
    ..Polymorphisms in exon 3 and exon 4 of the microsomal epoxide hydrolase gene (EPHX1) modify catalytic activity of this enzyme and subsequently may play a role in EC etiology...
  62. Hassett C, Robinson K, Beck N, Omiecinski C. The human microsomal epoxide hydrolase gene (EPHX1): complete nucleotide sequence and structural characterization. Genomics. 1994;23:433-42 pubmed
    ..We have isolated and sequenced clones that encode the entire human mEH gene (EPHX1)...
  63. Hartsfield J, Sutcliffe M, Everett E, Hassett C, Omiecinski C, Saari J. Assignment1 of microsomal epoxide hydrolase (EPHX1) to human chromosome 1q42.1 by in situ hybridization. Cytogenet Cell Genet. 1998;83:44-5 pubmed
  64. Tiemersma E, Omer R, Bunschoten A, van t Veer P, Kok F, Idris M, et al. Role of genetic polymorphism of glutathione-S-transferase T1 and microsomal epoxide hydrolase in aflatoxin-associated hepatocellular carcinoma. Cancer Epidemiol Biomarkers Prev. 2001;10:785-91 pubmed
    ..glutathione-S-transferase theta 1 gene (GSTT1) and microsomal epoxide hydrolase encoded by epoxide hydrolase gene (EPHX). The rate at which aflatoxins become activated or detoxified may depend on polymorphisms in the encoding genes...
  65. Zhu Q, Xing W, Qian B, von Dippe P, Shneider B, Fox V, et al. Inhibition of human m-epoxide hydrolase gene expression in a case of hypercholanemia. Biochim Biophys Acta. 2003;1638:208-16 pubmed
    ..Sequence analysis of the mEH gene (EPHX1) revealed a point mutation at an upstream HNF-3 site (allele I) and in intron 1 (allele II), which resulted in a ..
  66. van der Logt E, Bergevoet S, Roelofs H, Te Morsche R, Dijk Y, Wobbes T, et al. Role of epoxide hydrolase, NAD(P)H:quinone oxidoreductase, cytochrome P450 2E1 or alcohol dehydrogenase genotypes in susceptibility to colorectal cancer. Mutat Res. 2006;593:39-49 pubmed
    ..Therefore, we determined whether polymorphisms in the genes coding for microsomal epoxide hydrolase (EPHX1), NAD(P)H:quinone oxidoreductase (NQO1), cytochrome P450 2E1 (CYP2E1) and alcohol dehydrogenase (ADH3) predispose ..
  67. Rotunno M, Yu K, Lubin J, Consonni D, Pesatori A, Goldstein A, et al. Phase I metabolic genes and risk of lung cancer: multiple polymorphisms and mRNA expression. PLoS ONE. 2009;4:e5652 pubmed publisher
    ..Two haplotypes in EPHX1 were significantly associated with lung cancer risk in the overall population...
  68. Gold L, De Roos A, Brown E, Lan Q, Milliken K, Davis S, et al. Associations of common variants in genes involved in metabolism and response to exogenous chemicals with risk of multiple myeloma. Cancer Epidemiol. 2009;33:276-80 pubmed publisher
    ..in metabolism and response to exogenous chemicals [cytochrome P450 enzymes (CYP1B1, CYP2C9), epoxide hydrolase (EPHX1), paraoxonase 1 (PON1), arylhydrocarbon hydroxylase receptor (AHR), and NAD(P)H:quinone oxidoreductase (NQO1)]...
  69. Barry K, Zhang Y, Lan Q, Zahm S, Holford T, Leaderer B, et al. Genetic variation in metabolic genes, occupational solvent exposure, and risk of non-hodgkin lymphoma. Am J Epidemiol. 2011;173:404-13 pubmed publisher
    ..29, 95% CI: 0.84, 1.98) was increased among women AA for rs2234922 in the microsomal epoxide hydrolase gene, EPHX1 (OR = 1.77, 95% CI: 1.06, 2.97; P(interaction) = 0.06). In contrast, no effect was observed among AG/GG women...
  70. Zhao W, Luo J, Cai X. Association between microsomal epoxide hydrolase 1 polymorphisms and susceptibility to esophageal cancer: a meta-analysis. Tumour Biol. 2013;34:2383-8 pubmed publisher
    Microsomal epoxide hydrolase 1 (EPHX1) plays an important role in the detoxification of carcinogenic polycyclic aromatic hydrocarbons...
  71. Sachse C, Smith G, Wilkie M, Barrett J, Waxman R, Sullivan F, et al. A pharmacogenetic study to investigate the role of dietary carcinogens in the etiology of colorectal cancer. Carcinogenesis. 2002;23:1839-49 pubmed
    ..oxidoreductase (NQO1), methylenetetrahydrofolate reductase (MTHFR), and microsomal epoxide hydrolase (EPHX1) genes...
  72. Korhonen S, Romppanen E, Hiltunen M, Helisalmi S, Punnonen K, Hippeläinen M, et al. Two exonic single nucleotide polymorphisms in the microsomal epoxide hydrolase gene are associated with polycystic ovary syndrome. Fertil Steril. 2003;79:1353-7 pubmed
    To determine whether genetic variability in the gene encoding microsomal epoxide hydrolase (EPHX) contributes to individual differences in susceptibility to the development of polycystic ovary syndrome (PCOS)...
  73. Broberg K, Bjork J, Paulsson K, Hoglund M, Albin M. Constitutional short telomeres are strong genetic susceptibility markers for bladder cancer. Carcinogenesis. 2005;26:1263-71 pubmed
    ..e. smoking and polymorphisms in the genes involved in the metabolism of genotoxic carcinogens (EPHX1, GSTA1, GSTM1, GSTP1, GSTT1, NAT1, NAT2 and NQO1) or DNA repair (APE1, NBS1, XPC, XPD, XRCC1, XRCC3 and XRCC4), ..
  74. Robien K, Curtin K, Ulrich C, Bigler J, Samowitz W, Caan B, et al. Microsomal epoxide hydrolase polymorphisms are not associated with colon cancer risk. Cancer Epidemiol Biomarkers Prev. 2005;14:1350-2 pubmed
  75. Park J, Chen L, Elahi A, Lazarus P, Tockman M. Genetic analysis of microsomal epoxide hydrolase gene and its association with lung cancer risk. Eur J Cancer Prev. 2005;14:223-30 pubmed
    ..This association was more pronounced among patients with lung adenocarcinoma (OR 4.7, 95% CI 1.7-13.1). These results suggest that the EH polymorphism plays an important role in lung cancer risk and is linked to tobacco smoke exposure. ..
  76. Hersh C, DeMeo D, Reilly J, Silverman E. Xenobiotic metabolizing enzyme gene polymorphisms predict response to lung volume reduction surgery. Respir Res. 2007;8:59 pubmed
    ..003) and a coding SNP in microsomal epoxide hydrolase (EPHX1; p = 0.02) were each associated with change in BODE score...
  77. Graziano C, Comin C, Crisci C, Novelli L, Politi L, Messerini L, et al. Functional polymorphisms of the microsomal epoxide hydrolase gene: a reappraisal on a early-onset lung cancer patients series. Lung Cancer. 2009;63:187-93 pubmed publisher
    Microsomal epoxide hydrolase gene (EPHX1) is polymorphic and encodes an enzyme involved in both the activation and detoxification of several tobacco carcinogens...
  78. Chappell S, Daly L, Morgan K, Guetta Baranes T, Roca J, Rabinovich R, et al. Genetic variants of microsomal epoxide hydrolase and glutamate-cysteine ligase in COPD. Eur Respir J. 2008;32:931-7 pubmed publisher
    ..proposed, including enzymes that protect the lung against oxidative stress, such as microsomal epoxide hydrolase (EPHX1) and glutamate-cysteine ligase (GCL)...
  79. Lee M, Chen C, Chou C, Lu L, Chuang H, Chen Y, et al. Genetic determinants of warfarin dosing in the Han-Chinese population. Pharmacogenomics. 2009;10:1905-13 pubmed publisher
    ..In this study, we screened for SNPs in 13 genes (VKORC1, CYP2C9, CYP2C18, PROC, APOE, EPHX1, CALU, GGCX, ORM1, ORM2, factor II, factor VII and CYP4F2) and tested their associations with warfarin dosing with ..
  80. Hlavata I, Vrana D, Smerhovsky Z, Pardini B, Naccarati A, Vodicka P, et al. Association between exposure-relevant polymorphisms in CYP1B1, EPHX1, NQO1, GSTM1, GSTP1 and GSTT1 and risk of colorectal cancer in a Czech population. Oncol Rep. 2010;24:1347-53 pubmed
    Associations of functional single nucleotide polymorphisms in cytochrome P450 1B1, epoxide hydrolase 1, NAD(P)H:quinone oxidoreductase 1, glutathione S-transferase Pi-1 and deletions of glutathione S-transferases Mu-1 and ?-1 with ..
  81. Garte S, Gaspari L, Alexandrie A, Ambrosone C, Autrup H, Autrup J, et al. Metabolic gene polymorphism frequencies in control populations. Cancer Epidemiol Biomarkers Prev. 2001;10:1239-48 pubmed
    ..for many of the more commonly studied metabolic genes (CYP1A1, CYP2E1, CYP2D6, GSTM1, GSTT1, NAT2, GSTP, and EPHX) in the human population were determined...
  82. Spurdle A, Chang J, Byrnes G, Chen X, Dite G, McCredie M, et al. A systematic approach to analysing gene-gene interactions: polymorphisms at the microsomal epoxide hydrolase EPHX and glutathione S-transferase GSTM1, GSTT1, and GSTP1 loci and breast cancer risk. Cancer Epidemiol Biomarkers Prev. 2007;16:769-74 pubmed
    ..population-based sample of 1,246 cases and 664 controls to assess the roles of detoxification gene polymorphisms EPHX T>C Tyr(113)His, GSTT1 deletion, GSTM1 deletion, and GSTP1 A>G Ile(105)Val on risk of breast cancer...
  83. Ihsan R, Chattopadhyay I, Phukan R, Mishra A, Purkayastha J, Sharma J, et al. Role of epoxide hydrolase 1 gene polymorphisms in esophageal cancer in a high-risk area in India. J Gastroenterol Hepatol. 2010;25:1456-62 pubmed publisher
    Microsomal epoxide hydrolase 1 (EPHX1) is involved in the metabolism of environmental and tobacco carcinogens. Tobacco smoking, betel quid chewing, and alcohol consumption are the major known risk factors for esophageal cancer...
  84. Baxter S, Choong D, Campbell I. Microsomal epoxide hydrolase polymorphism and susceptibility to ovarian cancer. Cancer Lett. 2002;177:75-81 pubmed
    ..Furthermore previous disease association studies of exon 3 alleles which utilized the PCR-RFLP assay may be compromised by the existence of a codon 119 G>A polymorphism which may be common in Caucasian populations. ..
  85. Hersh C, DeMeo D, Lange C, Litonjua A, Reilly J, Kwiatkowski D, et al. Attempted replication of reported chronic obstructive pulmonary disease candidate gene associations. Am J Respir Cell Mol Biol. 2005;33:71-8 pubmed
    ..In addition, the microsomal epoxide hydrolase "fast" allele (EPHX1 His139Arg) was significantly associated in the case-control study (P = 0.03)...
  86. Wadelius M, Chen L, Eriksson N, Bumpstead S, Ghori J, Wadelius C, et al. Association of warfarin dose with genes involved in its action and metabolism. Hum Genet. 2007;121:23-34 pubmed
    ..In our study, polymorphisms in or flanking the genes VKORC1, CYP2C9, CYP2C18, CYP2C19, PROC, APOE, EPHX1, CALU, GGCX and ORM1-ORM2 and haplotypes of VKORC1, CYP2C9, CYP2C8, CYP2C19, PROC, F7, GGCX, PROZ, F9, NR1I2 and ..
  87. To Figueras J, Gené M, Gomez Catalan J, Piqué E, Borrego N, Caballero M, et al. Microsomal epoxide hydrolase and glutathione S-transferase polymorphisms in relation to laryngeal carcinoma risk. Cancer Lett. 2002;187:95-101 pubmed
    Two polymorphic sites of the microsomal epoxide hydrolase gene (EPHX1, 113Tyr-->113His, 139His-->139Arg) and four glutathione S-transferase genes (GSTM1, GSTM3, GSTP1, GSTT1) were genotyped in a group of patients with larynx cancer ..
  88. Zhang J, Jin X, Li Y, Wang R, Guo W, Wang N, et al. Epoxide hydrolase Tyr113His polymorphism is not associated with susceptibility to esophageal squamous cell carcinoma in population of North China. World J Gastroenterol. 2003;9:2654-7 pubmed
    To investigate the possible association of microsomal epoxide hydrolase (mEH) Tyr113His polymorphism with susceptibility to esophageal squamous cell carcinoma (ESCC) in a population of North China...
  89. Zusterzeel P, Peters W, Visser W, Hermsen K, Roelofs H, Steegers E. A polymorphism in the gene for microsomal epoxide hydrolase is associated with pre-eclampsia. J Med Genet. 2001;38:234-7 pubmed
    ..In addition, a significant association was found between predicted EPHX activity and pre-eclampsia...
  90. Wu X, Gwyn K, Amos C, Makan N, Hong W, Spitz M. The association of microsomal epoxide hydrolase polymorphisms and lung cancer risk in African-Americans and Mexican-Americans. Carcinogenesis. 2001;22:923-8 pubmed
    ..These findings suggest that the presence of the exon 4 and exon 3 polymorphisms of mEPHX may be associated with an increased risk of lung cancer particularly among younger Mexican-Americans in this study. ..
  91. Tranah G, Giovannucci E, Ma J, Fuchs C, Hankinson S, Hunter D. Epoxide hydrolase polymorphisms, cigarette smoking and risk of colorectal adenoma in the Nurses' Health Study and the Health Professionals Follow-up Study. Carcinogenesis. 2004;25:1211-8 pubmed
    Microsomal epoxide hydrolase (mEH) is involved in the bioactivation and detoxification of polycyclic aromatic hydrocarbons derived from tobacco smoke and charred meat intake...
  92. Skjelbred C, Saebø M, Hjartåker A, Grotmol T, Hansteen I, Tveit K, et al. Meat, vegetables and genetic polymorphisms and the risk of colorectal carcinomas and adenomas. BMC Cancer. 2007;7:228 pubmed
    ..fruit, berries and vegetables) genetic polymorphisms in biotransformation genes (GSTM1, GSTT1, GSTP1 Ile105Val, EPHX1 Tyr113His and EPHX1 His139Arg), and risk of colorectal carcinomas and adenomas...