EPHB2

Summary

Gene Symbol: EPHB2
Description: EPH receptor B2
Alias: CAPB, DRT, EK5, EPHT3, ERK, Hek5, PCBC, Tyro5, ephrin type-B receptor 2, EPH-like kinase 5, developmentally-regulated Eph-related tyrosine kinase, elk-related tyrosine kinase, eph tyrosine kinase 3, protein-tyrosine kinase HEK5, renal carcinoma antigen NY-REN-47, tyrosine-protein kinase TYRO5, tyrosine-protein kinase receptor EPH-3
Species: human
Products:     EPHB2

Top Publications

  1. Holland S, Gale N, Gish G, Roth R, Songyang Z, Cantley L, et al. Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells. EMBO J. 1997;16:3877-88 pubmed
    ..To investigate the biochemical mechanisms underlying such functions, we have expressed the EphB2 receptor (formerly Nuk/Cek5/Sek3) in neuronal NG108-15 cells, and have observed the tyrosine phosphorylation of ..
  2. Huusko P, Ponciano Jackson D, Wolf M, Kiefer J, Azorsa D, Tuzmen S, et al. Nonsense-mediated decay microarray analysis identifies mutations of EPHB2 in human prostate cancer. Nat Genet. 2004;36:979-83 pubmed
    ..This approach enabled us to identify previously unknown mutations in the receptor tyrosine kinase gene EPHB2. The DU 145 prostate cancer cell line, originating from a brain metastasis, carries a truncating mutation of EPHB2 ..
  3. Batlle E, Bacani J, Begthel H, Jonkheer S, Jonkeer S, Gregorieff A, et al. EphB receptor activity suppresses colorectal cancer progression. Nature. 2005;435:1126-30 pubmed
    ..Our data demonstrate that loss of EphB expression represents a critical step in colorectal cancer progression. ..
  4. Kokko A, Laiho P, Lehtonen R, Korja S, Carvajal Carmona L, Jarvinen H, et al. EPHB2 germline variants in patients with colorectal cancer or hyperplastic polyposis. BMC Cancer. 2006;6:145 pubmed
    Ephrin receptor B2 (EPHB2) has recently been proposed as a novel tumor suppressor gene in colorectal cancer (CRC)...
  5. Nakada M, Niska J, Miyamori H, McDonough W, Wu J, Sato H, et al. The phosphorylation of EphB2 receptor regulates migration and invasion of human glioma cells. Cancer Res. 2004;64:3179-85 pubmed
    ..b>EphB2 mRNA was overexpressed in all five during migration (1.2-2.8-fold)...
  6. Kittles R, Baffoe Bonnie A, Moses T, Robbins C, Ahaghotu C, Huusko P, et al. A common nonsense mutation in EphB2 is associated with prostate cancer risk in African American men with a positive family history. J Med Genet. 2006;43:507-11 pubmed
    The EphB2 gene was recently implicated as a prostate cancer (PC) tumour suppressor gene, with somatic inactivating mutations occurring in approximately 10% of sporadic tumours...
  7. Lugli A, Spichtin H, Maurer R, Mirlacher M, Kiefer J, Huusko P, et al. EphB2 expression across 138 human tumor types in a tissue microarray: high levels of expression in gastrointestinal cancers. Clin Cancer Res. 2005;11:6450-8 pubmed
    To comprehensively evaluate ephrin receptor B2 (EphB2) expression in normal and neoplastic tissues. EphB2 is a tyrosine kinase recently implicated in the deregulation of cell-to-cell communication in many tumors...
  8. Guo D, Zhang J, Yuen S, Tsui W, Chan A, Ho C, et al. Reduced expression of EphB2 that parallels invasion and metastasis in colorectal tumours. Carcinogenesis. 2006;27:454-64 pubmed
    b>EphB2, a receptor tyrosine kinase regulated by the beta-catenin/Tcf4 complex, is expressed in the proliferative compartment of mouse intestine and regulates bidirectional migration of intestinal precursor cells in the crypt-villus axis ..
  9. Kumar S, Scehnet J, Ley E, Singh J, Krasnoperov V, Liu R, et al. Preferential induction of EphB4 over EphB2 and its implication in colorectal cancer progression. Cancer Res. 2009;69:3736-45 pubmed publisher
    The receptor tyrosine kinase EphB2 is expressed by colon progenitor cells; however, only 39% of colorectal tumors express EphB2 and expression levels decline with disease progression...

More Information

Publications141 found, 100 shown here

  1. Raft S, Andrade L, Shao D, Akiyama H, Henkemeyer M, Wu D. Ephrin-B2 governs morphogenesis of endolymphatic sac and duct epithelia in the mouse inner ear. Dev Biol. 2014;390:51-67 pubmed publisher
    ..Mice deficient in either the EphB2 receptor tyrosine kinase or the cognate transmembrane ligand ephrin-B2 (Efnb2) exhibit background strain-specific ..
  2. Forse G, Uson M, Nasertorabi F, Kolatkar A, Lamberto I, Pasquale E, et al. Distinctive Structure of the EphA3/Ephrin-A5 Complex Reveals a Dual Mode of Eph Receptor Interaction for Ephrin-A5. PLoS ONE. 2015;10:e0127081 pubmed publisher
    ..complex reveals a pronounced tilt of the ephrin-A5 ligand compared to its orientation when bound to the EphA2 and EphB2 receptors and similar to its orientation when bound to EphA4...
  3. Zhang R, Han Y, Chen C, Xu L, Li J, Chen N, et al. EphB2 in the Medial Prefrontal Cortex Regulates Vulnerability to Stress. Neuropsychopharmacology. 2016;41:2541-56 pubmed publisher
    The ephrin B2 (EphB2) receptor is a tyrosine kinase receptor that is associated with synaptic development and maturation. It has recently been implicated in cognitive deficits and anxiety...
  4. Planaguma J, Haselmann H, Mannara F, Petit Pedrol M, Grünewald B, Aguilar E, et al. Ephrin-B2 prevents N-methyl-D-aspartate receptor antibody effects on memory and neuroplasticity. Ann Neurol. 2016;80:388-400 pubmed publisher
    To demonstrate that ephrin-B2 (the ligand of EphB2 receptor) antagonizes the pathogenic effects of patients' N-methyl-D-aspartate receptor (NMDAR) antibodies on memory and synaptic plasticity...
  5. Locke C, Machida K, Wu Y, Yu J. Optogenetic activation of EphB2 receptor in dendrites induced actin polymerization by activating Arg kinase. Biol Open. 2017;6:1820-1830 pubmed publisher
    ..b>EphB2 is well-expressed in the brain and known to be important for dendritic spine development, as well as for the ..
  6. Cho H, Hwang Y, Yoon J, Lee M, Lee H, Daar I. EphrinB1 promotes cancer cell migration and invasion through the interaction with RhoGDI1. Oncogene. 2018;37:861-872 pubmed publisher
    ..can interact with ephrinB1, and this interaction is enhanced upon binding the extracellular domain of the cognate EphB2 receptor...
  7. Mimche P, Lee C, Mimche S, Thapa M, Grakoui A, Henkemeyer M, et al. EphB2 receptor tyrosine kinase promotes hepatic fibrogenesis in mice via activation of hepatic stellate cells. Sci Rep. 2018;8:2532 pubmed publisher
    ..Here we report that upregulation of EphB2 is a prominent feature of two mouse models of hepatic fibrosis and also observed in humans with liver cirrhosis...
  8. Okumura F, Joo Okumura A, Obara K, Petersen A, Nishikimi A, Fukui Y, et al. Ubiquitin ligase SPSB4 diminishes cell repulsive responses mediated by EphB2. Mol Biol Cell. 2017;28:3532-3541 pubmed publisher
    ..The ectodomain of EphB2 receptor is cleaved by metalloproteinases (MMPs) MMP-2/MMP-9 and released into the extracellular space after ..
  9. Pasquale E. Exosomes expand the sphere of influence of Eph receptors and ephrins. J Cell Biol. 2016;214:5-7 pubmed publisher
    ..Gong et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201601085) show that cells can deploy the EphB2 receptor on exosomes to activate ephrinB signaling and collapse the growth cones of distant neurons.
  10. Perez de Arce K, Schrod N, Metzbower S, Allgeyer E, Kong G, Tang A, et al. Topographic Mapping of the Synaptic Cleft into Adhesive Nanodomains. Neuron. 2015;88:1165-1172 pubmed publisher
    ..insights, we analyzed the synapse-organizing proteins Synaptic Cell Adhesion Molecule 1 (SynCAM 1) and EphB2. Cryo-ET of SynCAM 1 knockout and overexpressor synapses showed that this immunoglobulin protein shapes the cleft'..
  11. Huroy S, Kanawaty A, Magomedova L, Cummins C, George S, van der Kooy D, et al. EphB2 reverse signaling regulates learned opiate tolerance via hippocampal function. Behav Brain Res. 2016;300:85-96 pubmed publisher
    ..We report that loss of EphB2 receptor reverse signaling results in a marked acceleration of morphine tolerance in vivo...
  12. Risley M, Garrod D, Henkemeyer M, McLean W. EphB2 and EphB3 forward signalling are required for palate development. Mech Dev. 2009;126:230-9 pubmed publisher
    ..Previous work had shown that the loss of ephrinB1 protein alone or compound loss of EphB2 and EphB3 leads to cleft palate...
  13. Taylor R, Heine M, Emptage N, Andreae L. Neuronal Receptors Display Cytoskeleton-Independent Directed Motion on the Plasma Membrane. iScience. 2018;10:234-244 pubmed publisher
    ..dot probe that specifically reports surface movement of receptors, we have identified a subpopulation of neuronal EphB2 receptors that exhibit directed motion between synapses within the plasma membrane itself...
  14. Hortigüela V, Larrañaga E, Cutrale F, Seriola A, García Díaz M, Lagunas A, et al. Nanopatterns of Surface-Bound EphrinB1 Produce Multivalent Ligand-Receptor Interactions That Tune EphB2 Receptor Clustering. Nano Lett. 2018;18:629-637 pubmed publisher
    ..surface able to produce multivalent interactions between surface-bound ephrinB1 ligands and membrane EphB2 receptors...
  15. Ladépêche L, Planaguma J, Thakur S, Suárez I, Hara M, Borbely J, et al. NMDA Receptor Autoantibodies in Autoimmune Encephalitis Cause a Subunit-Specific Nanoscale Redistribution of NMDA Receptors. Cell Rep. 2018;23:3759-3768 pubmed publisher
    ..Finally, activation of EphB2 receptor partially antagonized the antibody-mediated disorganization of the nanoscale surface distribution of ..
  16. Robichaux M, Chenaux G, Ho H, Soskis M, Greenberg M, Henkemeyer M, et al. EphB1 and EphB2 intracellular domains regulate the formation of the corpus callosum and anterior commissure. Dev Neurobiol. 2016;76:405-20 pubmed publisher
    ..We show here that the intracellular signaling domains of the EphB1 and EphB2 receptors are critical for formation of both the ACp and CC...
  17. Mazzio E, Soliman K. Whole-transcriptomic Profile of SK-MEL-3 Melanoma Cells Treated with the Histone Deacetylase Inhibitor: Trichostatin A. Cancer Genomics Proteomics. 2018;15:349-364 pubmed publisher
    ..showed that TSA down-regulated influential transcripts that drive the BRAF-extracellular signal-regulated kinase (ERK)1/2 oncogenic pathway (namely PRKCD and MYC proto-oncogene which negatively affected the cell-cycle distribution...
  18. Cui X, Qian D, Jiang S, Shang E, Zhu Z, Duan J. Scutellariae Radix and Coptidis Rhizoma Improve Glucose and Lipid Metabolism in T2DM Rats via Regulation of the Metabolic Profiling and MAPK/PI3K/Akt Signaling Pathway. Int J Mol Sci. 2018;19: pubmed publisher
    ..with down-regulation of MAPK (P38 mitogen-activated protein kinases (P38), extracellular regulated protein kinases (ERK), and c-Jun N-terminal kinase (JNK)) mRNA, and protein reduction in p-P65...
  19. Li C, Li L, Yang C, Zhong Y, Wu D, Shi L, et al. Hepatoprotective effects of Methyl ferulic acid on alcohol-induced liver oxidative injury in mice by inhibiting the NOX4/ROS-MAPK pathway. Biochem Biophys Res Commun. 2017;493:277-285 pubmed publisher
    ..lymphoma 2 (Bcl-2),cleaved-caspase 3 and 9 and phosphorylated extracellular regulated protein kinases(ERK),phosphorylated c-Jun N-terminal kinase (JNK), and phosphorylated p38 mitogen-activated protein kinase (MAPK) using ..
  20. Kawano H, Katayama Y, Minagawa K, Shimoyama M, Henkemeyer M, Matsui T. A novel feedback mechanism by Ephrin-B1/B2 in T-cell activation involves a concentration-dependent switch from costimulation to inhibition. Eur J Immunol. 2012;42:1562-72 pubmed publisher
    ..This modulation was virtually preserved in T cells from mice simultaneously lacking four genes, EphB1, EphB2, EphB3, and EphB6...
  21. Cai H, Su S, Li Y, Zeng H, Zhu Z, Guo J, et al. Protective effects of Salvia miltiorrhiza on adenine-induced chronic renal failure by regulating the metabolic profiling and modulating the NADPH oxidase/ROS/ERK and TGF-?/Smad signaling pathways. J Ethnopharmacol. 2018;212:153-165 pubmed publisher
    ..transition (EMT) of human renal tubular epithelial (HK-2) cell by inhibiting NADPH oxidase/ROS/ERK and TGF-?/Smad signaling pathways...
  22. Xie W, Zhou P, Sun Y, Meng X, Dai Z, Sun G, et al. Protective Effects and Target Network Analysis of Ginsenoside Rg1 in Cerebral Ischemia and Reperfusion Injury: A Comprehensive Overview of Experimental Studies. Cells. 2018;7: pubmed publisher
    ..activity and associated apoptosis via the Akt, Nrf2/HO-1, PPARγ/HO-1, extracellular regulated protein kinases (ERK), p38, and c-Jun N-terminal kinase (JNK) pathways (or mitochondrial apoptosis pathway) and the caspase-3/ROCK1/MLC ..
  23. Treffy R, Collins D, Hoshino N, Ton S, Katsevman G, Oleksiak M, et al. Ephrin-B/EphB Signaling Is Required for Normal Innervation of Lingual Gustatory Papillae. Dev Neurosci. 2016;38:124-38 pubmed publisher
    ..EphB1 and EphB2 were detected in lingual sensory afferents in vivo and geniculate neurites in vitro...
  24. Kiang J, Smith J, Anderson M, Elliott T, Gupta P, Balakathiresan N, et al. Hemorrhage enhances cytokine, complement component 3, and caspase-3, and regulates microRNAs associated with intestinal damage after whole-body gamma-irradiation in combined injury. PLoS ONE. 2017;12:e0184393 pubmed publisher
    ..Among the altered miRNAs, CI increased miR-34 in the serum and ileum which targeted an increased phosphorylation of ERK, p38, and increased NF-?B, thereby leading to increased iNOS expression and activation of caspase-3 in the ileum...
  25. Liao W, Qi Y, Wang L, Dong X, Xu T, Ding C, et al. Recql5 protects against lipopolysaccharide/D-galactosamine-induced liver injury in mice. World J Gastroenterol. 2015;21:10375-84 pubmed publisher
    ..Neutrophil infiltration was evaluated by myeloperoxidase activity. Expression and phosphorylation of ERK, JNK, p65, and H2A.X was determined by Western blot...
  26. Luo L, Li J, Liu H, Jian X, Zou Q, Zhao Q, et al. Adiponectin Is Involved in Connective Tissue Growth Factor-Induced Proliferation, Migration and Overproduction of the Extracellular Matrix in Keloid Fibroblasts. Int J Mol Sci. 2017;18: pubmed publisher
    ..Moreover, adiponectin inhibited the phosphorylation of AMPK, p38 and extracellular-regulated kinase (ERK), but not that of Jun N-terminal kinase (JNK) or Akt, in CTGF-treated KFs...
  27. Seo B, Ryu H, Park Y, Huh J, Baek Y. Dual effect of WIN-34B on osteogenesis and osteoclastogenesis in cytokine-induced mesenchymal stem cells and bone marrow cells. J Ethnopharmacol. 2016;193:227-236 pubmed publisher
    ..actin, p38 MAPK, phospho-c-Jun N-terminal kinase (JNK), phospho-extracellular-signal regulated kinase (ERK), phospho-p38 mitogen-activated protein kinase (MAPK), phospho-JNK, and phospho-ERK were measured by western blot ..
  28. Saucedo L, Buffa G, Rosso M, Guillardoy T, Góngora A, Munuce M, et al. Fibroblast Growth Factor Receptors (FGFRs) in Human Sperm: Expression, Functionality and Involvement in Motility Regulation. PLoS ONE. 2015;10:e0127297 pubmed publisher
    ..FGF2 caused an increase in flagellar FGFR phosphorylation and activation of extracellular signal-regulated kinase (ERK) and protein kinase B (PKB or Akt) signaling pathways...
  29. Freysdottir J, Logadottir O, Omarsdottir S, Vikingsson A, Hardardottir I. A polysaccharide fraction from Achillea millefolium increases cytokine secretion and reduces activation of Akt, ERK and NF-?B in THP-1 monocytes. Carbohydr Polym. 2016;143:131-8 pubmed publisher
    ..These findings indicate that Am-25-d isolated from A. millefolium has immunoenhancing properties that may be mediated via the Akt pathway. ..
  30. Roskoski R. Ibrutinib inhibition of Bruton protein-tyrosine kinase (BTK) in the treatment of B cell neoplasms. Pharmacol Res. 2016;113:395-408 pubmed publisher
    ..the phosphorylation and activation of phospholipase C?2 leading to the downstream activation of the Ras/RAF/MEK/ERK pathway and the NF-?B pathways. Both pathways participate in the maturation of antibody-producing B cells...
  31. Tarnawsky S, Yoshimoto M, Deng L, Chan R, Yoder M. Yolk sac erythromyeloid progenitors expressing gain of function PTPN11 have functional features of JMML but are not sufficient to cause disease in mice. Dev Dyn. 2017;246:1001-1014 pubmed publisher
    ..growth hypersensitivity to granulocyte-macrophage colony-stimulating factor (GM-CSF) and hyperactive RAS-ERK signaling. Mutant EMPs engrafted the spleens of neonatal recipients, but did not cause disease...
  32. Meijome T, Baughman J, Hooker R, Cheng Y, Ciovacco W, Balamohan S, et al. C-Mpl Is Expressed on Osteoblasts and Osteoclasts and Is Important in Regulating Skeletal Homeostasis. J Cell Biochem. 2016;117:959-69 pubmed publisher
    ..Two of the major signaling pathways by which OBs regulate osteoclastogenesis, MCSF/OPG/RANKL and EphrinB2-EphB2/B4, were unaffected in c-Mpl(-/-) OBs...
  33. Donnadieu J, Lachaier E, Peria M, Saidak Z, Dakpé S, Ikoli J, et al. Short-term culture of tumour slices reveals the heterogeneous sensitivity of human head and neck squamous cell carcinoma to targeted therapies. BMC Cancer. 2016;16:273 pubmed publisher
    ..the cell proliferation index (CPI) of tumour cells using Ki67 labelling and the activation status of the RAF-MEK-ERK cascade through ERK phosphorylation analysis...
  34. Berchicci M, Spinelli D, Di Russo F. New insights into old waves. Matching stimulus- and response-locked ERPs on the same time-window. Biol Psychol. 2016;117:202-215 pubmed publisher
    ..the response in a simple (SRT) and in a discriminative (DRT, equally probable Go/No-go) visuo-motor task...
  35. Grimberg Peters D, Büren C, Windolf J, Wahlers T, Paunel Görgülü A. Hyperbaric Oxygen Reduces Production of Reactive Oxygen Species in Neutrophils from Polytraumatized Patients Yielding in the Inhibition of p38 MAP Kinase and Downstream Pathways. PLoS ONE. 2016;11:e0161343 pubmed publisher
    ..Only slight suppression of ERK activity could be found. In addition, HBO did not influence neutrophil chemotaxis or apoptosis, respectively...
  36. Cornelison L, Hawkins J, Durham P. Elevated levels of calcitonin gene-related peptide in upper spinal cord promotes sensitization of primary trigeminal nociceptive neurons. Neuroscience. 2016;339:491-501 pubmed publisher
    ..adapter molecule 1 (Iba1) in the spinal cord and phosphorylated extracellular signal-regulated kinase (P-ERK) in the ganglion was studied using immunohistochemistry...
  37. Gao X, Chen G, Gao C, Zhang D, Kuan S, Stabile L, et al. MAP4K4 is a novel MAPK/ERK pathway regulator required for lung adenocarcinoma maintenance. Mol Oncol. 2017;11:628-639 pubmed publisher
    ..leading to aberrant activation of the mitogen-activated protein kinase (MAPK) pathways particularly the MAPK/ERK pathway...
  38. Imperial R, Toor O, Hussain A, Subramanian J, Masood A. Comprehensive pancancer genomic analysis reveals (RTK)-RAS-RAF-MEK as a key dysregulated pathway in cancer: Its clinical implications. Semin Cancer Biol. 2019;54:14-28 pubmed publisher
    ..its activating cell receptor, the receptor tyrosine kinases (RTKs), which together encompass the (RTK)-RAS-RAF-MEK-ERK axis, are central to oncogenesis...
  39. Wang C, Zhang Z, Xu T, Lou Y, Wang Q, Jin H, et al. Upregulating mTOR/ERK signaling with leonurine for promoting angiogenesis and tissue regeneration in a full-thickness cutaneous wound model. Food Funct. 2018;9:2374-2385 pubmed publisher
    ..the proliferation and migration and enhance the ability of in vitro angiogenesis through up-regulating the mTOR/ERK signaling pathway...
  40. Philip J, Razzaque M, Han M, Li J, Theccanat T, Xu X, et al. Regulation of mitochondrial oxidative stress by β-arrestins in cultured human cardiac fibroblasts. Dis Model Mech. 2015;8:1579-89 pubmed publisher
    ..arrestins are scaffold proteins that signal in G-protein-dependent and -independent pathways; for example, in ERK activation...
  41. Vajravelu B, Hong K, Al Maqtari T, Cao P, Keith M, Wysoczynski M, et al. C-Kit Promotes Growth and Migration of Human Cardiac Progenitor Cells via the PI3K-AKT and MEK-ERK Pathways. PLoS ONE. 2015;10:e0140798 pubmed publisher
    ..These results imply that the efficiency of CPC homing to the injury site as well as their survival after transplantation may be improved by modulating the activity of c-kit. ..
  42. Zeke A, Bastys T, Alexa A, Garai Ã, Mészáros B, Kirsch K, et al. Systematic discovery of linear binding motifs targeting an ancient protein interaction surface on MAP kinases. Mol Syst Biol. 2015;11:837 pubmed publisher
    ..protein interaction surface on evolutionarily related but physiologically clearly distinct three MAPKs (JNK, ERK, and p38)...
  43. Bae W, Auh Q, Lim H, Kim G, Kim H, Kim E. Sonic Hedgehog Promotes Cementoblastic Differentiation via Activating the BMP Pathways. Calcif Tissue Int. 2016;99:396-407 pubmed publisher
    ..rh-SHH increased the expression of BMP-2 and -4 mRNA, as well as levels of phosphorylated Akt, ERK, p38, and JNK, and of MAPK and NF-κB activation, which were reversed by noggin, Cy, and BMP-2 siRNA...
  44. Xiang Q, Yu C, Zhu Y, Li C, Tian R, Li X. Nuclear factor erythroid 2-related factor 2 antibody attenuates thermal hyperalgesia in the dorsal root ganglion: Neurochemical changes and behavioral studies after sciatic nerve-pinch injury. Injury. 2016;47:1647-54 pubmed publisher
    ..significantly decreased after application of Nrf2 antibody (5ul, 1mg/ml) in such injured animals and phosphorylated ERK(p-ERK) as well as the apoptotic protein (i.e...
  45. Lu C, Lin T, Chang C, Huang S, Wang S. Ciproxifan, a histamine H3 receptor antagonist and inverse agonist, presynaptically inhibits glutamate release in rat hippocampus. Toxicol Appl Pharmacol. 2017;319:12-21 pubmed publisher
    ..PGE2 subtype 2 (EP2) receptor antagonist PF04418948, and extracellular signal-regulated kinase (ERK) inhibitor FR180204 eliminated the inhibitory effect of ciproxifan on glutamate release...
  46. Wang Y, Wang M, Chen B, Shi J. Scoparone attenuates high glucose-induced extracellular matrix accumulation in rat mesangial cells. Eur J Pharmacol. 2017;815:376-380 pubmed publisher
    ..that scoparone prevented the activation of ERK1/2 signaling pathway in high glucose-exposed mesangial cells, and an ERK inhibitor (U0126) protected mesangial cells treated with high glucose...
  47. Johnson D, Childress M, Chalmers Z, Frampton G, Ali S, Rubinstein S, et al. BRAF internal deletions and resistance to BRAF/MEK inhibitor therapy. Pigment Cell Melanoma Res. 2017;: pubmed publisher
    ..domain, and is analogous to previously documented BRAF fusions and splice variants known to reactivate RAS-RAF-MEK-ERK signaling. In a large cohort of melanomas, 10 additional internal deletions were identified (0...
  48. Liu J, Zhao X, Pei D, Sun G, Li Y, Zhu C, et al. The promotion function of Berberine for osteogenic differentiation of human periodontal ligament stem cells via ERK-FOS pathway mediated by EGFR. Sci Rep. 2018;8:2848 pubmed publisher
    ..In conclusion, BER may bind to EGFR on the cell membrane of hPDLSC so the intracellular ERK signalling pathways activate, and nuclear-related genes of FOS change, resulting in the effect of osteogenesis on ..
  49. Tanabe H, Kuribayashi K, Tsuji N, Tanaka M, Kobayashi D, Watanabe N. Sesamin induces autophagy in colon cancer cells by reducing tyrosine phosphorylation of EphA1 and EphB2. Int J Oncol. 2011;39:33-40 pubmed publisher
    Receptor tyrosine kinase EphB2 and autophagic machinery are known as tumor suppressors; however, the connection remains to be elucidated. Here, we show the link between EphB2 and autophagy...
  50. Siddesha J, Valente A, Sakamuri S, Yoshida T, Gardner J, Somanna N, et al. Angiotensin II stimulates cardiac fibroblast migration via the differential regulation of matrixins and RECK. J Mol Cell Cardiol. 2013;65:9-18 pubmed publisher
    ..In vitro, Ang II suppressed RECK expression in adult mouse cardiac fibroblasts (CF) via AT1/Nox4-dependent ERK/Sp1 activation, but induced MMPs 2, 14 and 9 via NF-κB, AP-1 and/or Sp1 activation...
  51. Chen P, Rossi N, Priddy S, Pierson C, Studebaker A, Johnson R. EphB2 activation is required for ependymoma development as well as inhibits differentiation and promotes proliferation of the transformed cell. Sci Rep. 2015;5:9248 pubmed publisher
    Our intracranial implantation mouse model of ependymoma clearly demonstrates overexpression of the ephrin receptor EphB2 in Ink4a/Arf((-/-)) supratentorial embryonic neural stem cells (STeNSCs) to be essential for transformation and ..
  52. Bassett J, van der Spek A, Logan J, Gogakos A, Bagchi Chakraborty J, Williams A, et al. Thyrostimulin Regulates Osteoblastic Bone Formation During Early Skeletal Development. Endocrinology. 2015;156:3098-113 pubmed publisher
    ..However, thyrostimulin failed to induce a canonical cAMP response or activate the noncanonical Akt, ERK, or mitogen-activated protein kinase (P38) signaling pathways in primary calvarial or bone marrow stromal cell-..
  53. Larrue C, Saland E, Vergez F, Serhan N, Delabesse E, Mansat De Mas V, et al. Antileukemic Activity of 2-Deoxy-d-Glucose through Inhibition of N-Linked Glycosylation in Acute Myeloid Leukemia with FLT3-ITD or c-KIT Mutations. Mol Cancer Ther. 2015;14:2364-73 pubmed publisher
    ..In these cells, 2-DG inhibited the cell-surface expression of c-KIT, abrogated STAT3 and MAPK-ERK pathways, and strongly downregulated the expression of the receptor resulting in a strong in vivo effect in NOD/..
  54. Zhao J, Chen C, Guo M, Tao Y, Cui P, Zhou Y, et al. MicroRNA-7 Deficiency Ameliorates the Pathologies of Acute Lung Injury through Elevating KLF4. Front Immunol. 2016;7:389 pubmed
    ..of miR-7, was upregulated in lung tissues in ALI model, accompanied by altered transduction of NF-?B, AKT, and ERK pathway...
  55. Ogasawara N, Matsushima M, Kawamura N, Atsumi K, Yamaguchi T, Ochi H, et al. Modulation of immunological activity on macrophages induced by diazinon. Toxicology. 2017;379:22-30 pubmed publisher
    ..7 cells. ERK and p38, but not JNK and p65 were involved in diazinon-induced IL-6 expression in RAW264.7 cells...
  56. Kumari P, Srivastava A, Ghosh E, Ranjan R, Dogra S, Yadav P, et al. Core engagement with ?-arrestin is dispensable for agonist-induced vasopressin receptor endocytosis and ERK activation. Mol Biol Cell. 2017;28:1003-1010 pubmed publisher
    ..Furthermore, this core interaction-deficient V2R mutant exhibits efficient endocytosis and ERK activation upon agonist stimulation...
  57. Song N, Jing W, Li C, Bai M, Cheng Y, Li H, et al. ZEB1 inhibition sensitizes cells to the ATR inhibitor VE-821 by abrogating epithelial-mesenchymal transition and enhancing DNA damage. Cell Cycle. 2017;:1-32 pubmed publisher
    ..reversed VE-821-induced EMT, and sensitized cells to VE-821 via effective attenuation of migration and AKT/ERK signaling...
  58. Tian J, Zhao Y, Liu Y, Liu Y, Chen K, Lyu S. Roles and Mechanisms of Herbal Medicine for Diabetic Cardiomyopathy: Current Status and Perspective. Oxid Med Cell Longev. 2017;2017:8214541 pubmed publisher
    ..protein kinase (p38 MAPK), c-Jun N-terminal kinase (JNK), and extracellular-regulated protein kinases (ERK) take roles in the pathogenesis of DCM...
  59. Chen X, Han R, Hao P, Wang L, Liu M, Jin M, et al. Nepetin inhibits IL-1? induced inflammation via NF-?B and MAPKs signaling pathways in ARPE-19 cells. Biomed Pharmacother. 2018;101:87-93 pubmed publisher
    ..Also, Nepetin can decrease the phosphorylation of extracellular signal-regulated kinases (ERK) 1/2, c-Jun N-terminal kinase (JNK) and p38 MAPK...
  60. Karthikeyan S, Russo A, DEAN M, Lantvit D, Endsley M, Burdette J. Prolactin signaling drives tumorigenesis in human high grade serous ovarian cancer cells and in a spontaneous fallopian tube derived model. Cancer Lett. 2018;433:221-231 pubmed publisher
    ..PRL was found to phosphorylate STAT5, m-TOR and ERK in ovarian cancer cells...
  61. Linley A, Mathieu M, Miles A, Rees R, McArdle S, Regad T. The helicase HAGE expressed by malignant melanoma-initiating cells is required for tumor cell proliferation in vivo. J Biol Chem. 2012;287:13633-43 pubmed publisher
    ..led to a significant decrease in RAS protein expression with a concomitant decrease in activation of the AKT and ERK signaling pathways implicated to play an important role in melanoma progression...
  62. Shen Z, Deng H, Fang Y, Zhu X, Ye G, Yan L, et al. Identification of the interplay between SOX9 and S100P in the metastasis and invasion of colon carcinoma. Oncotarget. 2015;6:20672-84 pubmed
    ..of colon cancer cells by inhibiting the activation of receptor for advanced glycation end products (RAGE)/ERK signaling and epithelial-mesenchymal transition (EMT)...
  63. Park M, Lee C. Effects of cerulein on keratin 8 phosphorylation and perinuclear reorganization in pancreatic cancer cells: Involvement of downregulation of protein phosphatase 2A and alpha4. Environ Toxicol. 2016;31:2090-2098 pubmed publisher
    ..The extracellular signal-regulated kinases (ERK) inhibitor U0126 suppressed cerulein-induced phosphorylation of serine 431 and reorganization of K8...
  64. Kaur A, Elzagheid A, Birkman E, Avoranta T, Kytölä V, Korkeila E, et al. Protein phosphatase methylesterase-1 (PME-1) expression predicts a favorable clinical outcome in colorectal cancer. Cancer Med. 2015;4:1798-808 pubmed publisher
    ..in CRC cell lines did not reduce the viability of cells or the expression of active phosphorylated AKT and ERK proteins. In conclusion, PME-1 expression predicts for a favorable outcome of CRC patients...
  65. Casella S, Bielli A, Mauriello A, Orlandi A. Molecular Pathways Regulating Macrovascular Pathology and Vascular Smooth Muscle Cells Phenotype in Type 2 Diabetes. Int J Mol Sci. 2015;16:24353-68 pubmed publisher
    ..growth-factor receptors (IGFR) are implicated in the activation of Akt and extracellular-signal-regulated kinases (ERK) 1/2. Nuclear factor-κB is also responsible of increased susceptibility of VSMCs to pro-apoptotic stimuli...
  66. Xu L, Qi Y, Xu Y, Lian J, Wang X, Ning G, et al. Co-inhibition of EGFR and IGF1R synergistically impacts therapeutically on adrenocortical carcinoma. Oncotarget. 2016;7:36235-36246 pubmed publisher
    ..and NVP-AEW541 significantly inhibited cell viability and induced apoptosis by blocking phosphorylation of MEK/ERK and AKT, respectively...
  67. Panayiotou R, Miralles F, Pawlowski R, Diring J, Flynn H, Skehel M, et al. Phosphorylation acts positively and negatively to regulate MRTF-A subcellular localisation and activity. elife. 2016;5: pubmed publisher
    ..The MRTFs also undergo Rho- and ERK-dependent phosphorylation, but the function of MRTF phosphorylation, and the elements and signals involved in MRTF-..
  68. Mingione A, Verdelli C, Ferrero S, Vaira V, Guarnieri V, Scillitani A, et al. Filamin A is reduced and contributes to the CASR sensitivity in human parathyroid tumors. J Mol Endocrinol. 2017;58:91-103 pubmed publisher
    ..FLNA expression in human parathyroid tumors, (2) its effects on the CASR mRNA and protein expression, and (3) on ERK signaling activation, (4) the effect of the carboxy-terminal CASR variants and (5) of the treatment with the CASR ..
  69. Chen X, Zhang S, Xuan Z, Ge D, Chen X, Zhang J, et al. The Phenolic Fraction of Mentha haplocalyx and Its Constituent Linarin Ameliorate Inflammatory Response through Inactivation of NF-κB and MAPKs in Lipopolysaccharide-Induced RAW264.7 Cells. Molecules. 2017;22: pubmed publisher
    ..phosphorylation content of NF-κB p65, inhibitor kappa B α (IκBα), extracellular signal-regulated kinase (ERK), c-Jun NH₂-terminal kinase (JNK), and p38...
  70. Prasasya R, Mayo K. Notch Signaling Regulates Differentiation and Steroidogenesis in Female Mouse Ovarian Granulosa Cells. Endocrinology. 2018;159:184-198 pubmed publisher
    ..Overall, this study reveals a role of Notch signaling in promoting the differentiation of preovulatory granulosa cells, adding to the diverse functions of Notch in the mammalian ovary. ..
  71. Chen D, Si W, Shen J, Du C, Lou W, Bao C, et al. miR-27b-3p inhibits proliferation and potentially reverses multi-chemoresistance by targeting CBLB/GRB2 in breast cancer cells. Cell Death Dis. 2018;9:188 pubmed publisher
    ..that miR-27b enhanced responses to PTX by directly targeting CBLB and GRB2 to inactivate both PI3K/Akt and MAPK/Erk signaling pathways...
  72. Robertson E, Weir L, Romanowska M, Leigh I, Panteleyev A. ARNT controls the expression of epidermal differentiation genes through HDAC- and EGFR-dependent pathways. J Cell Sci. 2012;125:3320-32 pubmed publisher
    ..Collectively, our results suggest that ARNT controls AREG expression and the downstream EGFR-ERK pathway in keratinocytes, at least in part, by modulating HDAC activity...
  73. Mi Y, Xiao C, Du Q, Wu W, Qi G, Liu X. Momordin Ic couples apoptosis with autophagy in human hepatoblastoma cancer cells by reactive oxygen species (ROS)-mediated PI3K/Akt and MAPK signaling pathways. Free Radic Biol Med. 2016;90:230-42 pubmed publisher
    ..Ic induces apoptosis by suppressing PI3K/Akt-dependent NF-κB pathways and promotes autophagy by ROS-mediated Erk signaling pathway...
  74. Yadav V, Hong K, Zeldin D, Nayeem M. Vascular endothelial over-expression of soluble epoxide hydrolase (Tie2-sEH) enhances adenosine A1 receptor-dependent contraction in mouse mesenteric arteries: role of ATP-sensitive K+ channels. Mol Cell Biochem. 2016;422:197-206 pubmed
    ..blot analysis revealed significantly higher basal protein expression of CYP4A, A1AR, and reduced p-ERK in MAs of Tie2-sEH Tr mice...
  75. Lewinska A, Adamczyk Grochala J, Kwasniewicz E, Deregowska A, Wnuk M. Diosmin-induced senescence, apoptosis and autophagy in breast cancer cells of different p53 status and ERK activity. Toxicol Lett. 2017;265:117-130 pubmed publisher
    ..Taken together, diosmin that acts at low micromolar range against breast cancer cells may be considered as a promising candidate for anticancer therapy. ..
  76. Sulpizio V, Lucci G, Berchicci M, Galati G, Pitzalis S, Di Russo F. Hemispheric asymmetries in the transition from action preparation to execution. Neuroimage. 2017;148:390-402 pubmed publisher
    ..functional magnetic resonance imaging (fMRI) while participants performed a discriminative response task (DRT) and a simple response task (SRT) using their non-dominant left hand...
  77. Liao C, Cheng T, Wang S, Zhang C, Jin L, Yang Y. Shear stress inhibits IL-17A-mediated induction of osteoclastogenesis via osteocyte pathways. Bone. 2017;101:10-20 pubmed publisher
    ..that potentially mediate these effects in osteocytes, and found that the extracellular signal-regulated kinase (ERK)1/2 and signal transducer and activator of transcription (STAT3) pathways were suppressed by IL-17A but induced by ..
  78. Wang M, Qiu C, Yu W, Guo Y, Wang C, Chen Z. GOLPH3 expression promotes the resistance of HT29 cells to 5?fluorouracil by activating multiple signaling pathways. Mol Med Rep. 2017;: pubmed publisher
    ..which indicated that its mechanism was associated with the activation of the mitogen?activated protein kinase/ERK and Wnt/??catenin signaling pathways...
  79. Fukumoto S, Kanbara K, Neo M. Synergistic anti-proliferative effects of mTOR and MEK inhibitors in high-grade chondrosarcoma cell line OUMS-27. Acta Histochem. 2018;120:142-150 pubmed publisher
    ..We investigated the mechanism of anti-proliferative effect of the mTOR inhibitor rapamycin and MAPK/ERK (MEK) inhibitor PD 0325901, and the combined effect of rapamycin and PD 0325901 on human chondrosarcoma cell line (..
  80. Hutton S, Otis J, Kim E, Lamsal Y, Stuber G, Snider W. ERK/MAPK Signaling Is Required for Pathway-Specific Striatal Motor Functions. J Neurosci. 2017;37:8102-8115 pubmed publisher
    The ERK/MAPK intracellular signaling pathway is hypothesized to be a key regulator of striatal activity via modulation of synaptic plasticity and gene transcription...
  81. Botteri G, Montori M, Guma A, Pizarro J, Cedó L, Escola Gil J, et al. VLDL and apolipoprotein CIII induce ER stress and inflammation and attenuate insulin signalling via Toll-like receptor 2 in mouse skeletal muscle cells. Diabetologia. 2017;60:2262-2273 pubmed publisher
    ..The changes caused by VLDL were dependent on extracellular signal-regulated kinase (ERK) 1/2 since they were prevented by the ERK1/2 inhibitor U0126 or by knockdown of this kinase by siRNA transfection...
  82. Srámek J, Němcová Fürstová V, Pavlikova N, Kovar J. Effect of Saturated Stearic Acid on MAP Kinase and ER Stress Signaling Pathways during Apoptosis Induction in Human Pancreatic ?-Cells Is Inhibited by Unsaturated Oleic Acid. Int J Mol Sci. 2017;18: pubmed publisher
    ..stearic acid (SA) on the p38 mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinase (ERK) pathways as well as the ER stress signaling pathways during apoptosis induction in the human pancreatic ?-cells ..
  83. Sandirasegarane L, Charles R, Bourbon N, Kester M. NO regulates PDGF-induced activation of PKB but not ERK in A7r5 cells: implications for vascular growth arrest. Am J Physiol Cell Physiol. 2000;279:C225-35 pubmed
    ..for growth factor receptor-mediated VSMC proliferation include the extracellular signal-regulated kinase (ERK) and possibly the protein kinase B (PKB) cascade...
  84. Li G, Tao H, Zhou C, Wang D, Peng C. Midazolam prevents motor neuronal death from oxidative stress attack mediated by JNK-ERK pathway. Hum Cell. 2018;31:64-71 pubmed publisher
    ..Furthermore, this effect was correlated with the JNK-ERK signaling pathway...
  85. Miethe C, Nix H, Martin R, Hernandez A, Price R. Silibinin Reduces the Impact of Obesity on Invasive Liver Cancer. Nutr Cancer. 2017;:1-9 pubmed publisher
    ..These physiological changes corresponded with decreased FASN, IL-6, IL-1B, and phosphorylated Erk. We describe the differential effect of sera from OB, OW, and NW males on characteristics relevant for liver cancer ..
  86. Herz C, Tran H, Schlotz N, MICHELS K, Lamy E. Low-dose levels of bisphenol A inhibit telomerase via ER/GPR30-ERK signalling, impair DNA integrity and reduce cell proliferation in primary PBMC. Sci Rep. 2017;7:16631 pubmed publisher
    ..Mechanistic studies were carried out on the ER/GPR30-ERK pathway using specific inhibitors/antagonists, the comet assay to quantify DNA damage and flow cytometry for cell ..
  87. Zisch A, Pazzagli C, Freeman A, Schneller M, Hadman M, Smith J, et al. Replacing two conserved tyrosines of the EphB2 receptor with glutamic acid prevents binding of SH2 domains without abrogating kinase activity and biological responses. Oncogene. 2000;19:177-87 pubmed
    ..Here, we investigate the role of tyrosines 605 and 611 in the juxtamembrane region of EphB2, because they are conserved Eph receptor autophosphorylation sites and demonstrated binding sites for the SH2 ..
  88. Liu N, Liu X, Li X, Duan K, Deng Y, Yu X, et al. DOK3 Degradation is Required for the Development of LPS-induced ARDS in Mice. Curr Gene Ther. 2016;16:256-262 pubmed publisher
    ..In addition, DOK3 expression apparently suppressed LPS-induced NF-?B and ERK activation...
  89. Tarhouni Jabberi S, Zakraoui O, Ioannou E, Riahi Chebbi I, Haoues M, Roussis V, et al. Mertensene, a Halogenated Monoterpene, Induces G2/M Cell Cycle Arrest and Caspase Dependent Apoptosis of Human Colon Adenocarcinoma HT29 Cell Line through the Modulation of ERK-1/-2, AKT and NF-κB Signaling. Mar Drugs. 2017;15: pubmed publisher
    ..exposure of HT29 cells to different concentrations of mertensene correlated with the activation of MAPK ERK-1/-2, Akt and NF-κB pathways...
  90. Xu L, Zhang Z, Sun X, Wang J, Xu W, Shi L, et al. Glycosylation status of bone sialoprotein and its role in mineralization. Exp Cell Res. 2017;360:413-420 pubmed publisher
    ..Moreover, BSP-conjugated SAs may affect mineralization via ERK activation of VDR expression...
  91. Chandra M, Escalante Alcalde D, Bhuiyan M, Orr A, KEVIL C, Morris A, et al. Cardiac-specific inactivation of LPP3 in mice leads to myocardial dysfunction and heart failure. Redox Biol. 2018;14:261-271 pubmed publisher
    ..We found that lack of Lpp3 signaling was mediated through the activation of Rho and phospho-ERK pathways...
  92. He Y, Hu Y, Jiang X, Chen T, Ma Y, Wu S, et al. Cyanidin-3-O-glucoside inhibits the UVB-induced ROS/COX-2 pathway in HaCaT cells. J Photochem Photobiol B. 2017;177:24-31 pubmed publisher
    ..than Celecoxib, which translated into a stronger inhibitory effect against the downstream elements p38, ERK, and JNK...