Gene Symbol: EphA4
Description: EPH receptor A4
Alias: HEK8, SEK, TYRO1, ephrin type-A receptor 4, EK8, EPH-like kinase 8, TYRO1 protein tyrosine kinase, receptor protein-tyrosine kinase HEK8, tyrosine-protein kinase TYRO1, tyrosine-protein kinase receptor SEK
Species: human
Products:     EphA4

Top Publications

  1. Xu Q, Mellitzer G, Wilkinson D. Roles of Eph receptors and ephrins in segmental patterning. Philos Trans R Soc Lond B Biol Sci. 2000;355:993-1002 pubmed
    ..Eph receptors and ephrins have thus emerged as key regulators that, in parallel with cell adhesion molecules, underlie the establishment and maintenance of patterns of cellular organization. ..
  2. Brors D, Bodmer D, Pak K, Aletsee C, Schäfers M, Dazert S, et al. EphA4 provides repulsive signals to developing cochlear ganglion neurites mediated through ephrin-B2 and -B3. J Comp Neurol. 2003;462:90-100 pubmed
    ..Recently, expression of EphA4 in the developing cochlea was shown, with strong expression in cells lining the osseous spiral lamina (OSL) ..
  3. Murai K, Nguyen L, Irie F, Yamaguchi Y, Pasquale E. Control of hippocampal dendritic spine morphology through ephrin-A3/EphA4 signaling. Nat Neurosci. 2003;6:153-60 pubmed
    ..Here we describe a repulsive interaction that regulates postsynaptic morphology through the EphA4 receptor tyrosine kinase and its ligand ephrin-A3...
  4. Fukai J, Yokote H, Yamanaka R, Arao T, Nishio K, Itakura T. EphA4 promotes cell proliferation and migration through a novel EphA4-FGFR1 signaling pathway in the human glioma U251 cell line. Mol Cancer Ther. 2008;7:2768-78 pubmed publisher
    ..The analysis, focused on the receptor tyrosine kinases, showed that EphA4 mRNA in the tumors was 4-fold higher than in normal brain tissue...
  5. Giaginis C, Tsourouflis G, Zizi Serbetzoglou A, Kouraklis G, Chatzopoulou E, Dimakopoulou K, et al. Clinical significance of ephrin (eph)-A1, -A2, -a4, -a5 and -a7 receptors in pancreatic ductal adenocarcinoma. Pathol Oncol Res. 2010;16:267-76 pubmed publisher
  6. Shen L, Kim S, Risacher S, Nho K, Swaminathan S, West J, et al. Whole genome association study of brain-wide imaging phenotypes for identifying quantitative trait loci in MCI and AD: A study of the ADNI cohort. Neuroimage. 2010;53:1051-63 pubmed publisher
    ..Other top SNPs were proximal to the EPHA4, TP63 and NXPH1 genes...
  7. Fu A, Hung K, Fu W, Shen C, Chen Y, Xia J, et al. APC(Cdh1) mediates EphA4-dependent downregulation of AMPA receptors in homeostatic plasticity. Nat Neurosci. 2011;14:181-9 pubmed publisher
    ..We found that activation of EphA4 resulted in a decrease in synaptic and surface GluR1 and attenuated mEPSC amplitude through a degradation pathway ..
  8. Van Hoecke A, Schoonaert L, Lemmens R, Timmers M, Staats K, Laird A, et al. EPHA4 is a disease modifier of amyotrophic lateral sclerosis in animal models and in humans. Nat Med. 2012;18:1418-22 pubmed
    ..Here, we have screened a zebrafish model of ALS and identified Epha4, a receptor in the ephrin axonal repellent system, as a modifier of the disease phenotype in fish, rodents and ..
  9. Gale N, Holland S, Valenzuela D, Flenniken A, Pan L, Ryan T, et al. Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis. Neuron. 1996;17:9-19 pubmed
    ..This reciprocal compartmentalization implicates the Eph family in the formation of spatial boundaries that may help to organize the developing body plan. ..

More Information

Publications116 found, 100 shown here

  1. Fu W, Chen Y, Sahin M, Zhao X, Shi L, Bikoff J, et al. Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism. Nat Neurosci. 2007;10:67-76 pubmed
    ..Dendritic spines are retracted upon Eph receptor A4 (EphA4) activation, but the mechanisms that control this process are not well understood...
  2. Bowden T, Aricescu A, Nettleship J, Siebold C, Rahman Huq N, Owens R, et al. Structural plasticity of eph receptor A4 facilitates cross-class ephrin signaling. Structure. 2009;17:1386-97 pubmed publisher
    The EphA4 tyrosine kinase cell surface receptor regulates an array of physiological processes and is the only currently known class A Eph receptor that binds both A and B class ephrins with high affinity...
  3. Ende G, Poitz D, Wiedemann E, Augstein A, Friedrichs J, Giebe S, et al. TNF-α-mediated adhesion of monocytes to endothelial cells-The role of ephrinA1. J Mol Cell Cardiol. 2014;77:125-35 pubmed publisher
    ..Furthermore, this effect is mediated via the EphA4 receptor...
  4. Mukai M, Suruga N, Saeki N, Ogawa K. EphA receptors and ephrin-A ligands are upregulated by monocytic differentiation/maturation and promote cell adhesion and protrusion formation in HL60 monocytes. BMC Cell Biol. 2017;18:28 pubmed publisher
    ..Moreover, EphA2 and EphA4 expression was induced, and ephrin-A4 expression was upregulated, in a human promyelocytic leukemia cell line, ..
  5. Alonso Martin S, Rochat A, Mademtzoglou D, Morais J, de Reynies A, Aurade F, et al. Gene Expression Profiling of Muscle Stem Cells Identifies Novel Regulators of Postnatal Myogenesis. Front Cell Dev Biol. 2016;4:58 pubmed publisher
    ..including set of genes specifically induced (EphA1, EphA2, EfnA1, EphB1, Zbtb4, Zbtb20) or inhibited (EphA3, EphA4, EphA7, EfnA2, EfnA3, EfnA4, EfnA5, EphB2, EphB3, EphB4, EfnBs, Zfp354c, Zcchc5, Hmga2) in adult stem cells...
  6. Lu H, Clauser K, Tam W, Fröse J, Ye X, Eaton E, et al. A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages. Nat Cell Biol. 2014;16:1105-17 pubmed publisher
    ..proteomic profiling and found that the EMT program upregulates the expression of CD90, also known as Thy1, and EphA4, which mediate the physical interactions of CSCs with TAMs by directly binding with their respective counter-..
  7. Forse G, Uson M, Nasertorabi F, Kolatkar A, Lamberto I, Pasquale E, et al. Distinctive Structure of the EphA3/Ephrin-A5 Complex Reveals a Dual Mode of Eph Receptor Interaction for Ephrin-A5. PLoS ONE. 2015;10:e0127081 pubmed publisher
    ..to its orientation when bound to the EphA2 and EphB2 receptors and similar to its orientation when bound to EphA4. This tilt brings an additional area of ephrin-A5 into contact with regions of EphA3 outside the ephrin-binding ..
  8. Khokhlova O, Hung W, Wan T, Iwao Y, Takano T, Higuchi W, et al. Healthcare- and Community-Associated Methicillin-Resistant Staphylococcus aureus (MRSA) and Fatal Pneumonia with Pediatric Deaths in Krasnoyarsk, Siberian Russia: Unique MRSA's Multiple Virulence Factors, Genome, and Stepwise Evolution. PLoS ONE. 2015;10:e0128017 pubmed publisher
    ..shock syndrome toxin-1 (TSST-1), elevated PSMα/Hld expression, α-hemolysin, the staphylococcal enterotoxin SEK/SEQ, the immune evasion factor SCIN/SAK, and collagen adhesin...
  9. Nussinov R, Ma B. Protein dynamics and conformational selection in bidirectional signal transduction. BMC Biol. 2012;10:2 pubmed publisher
    ..The multiple conformations of the free EphA4 ligand-binding domain observed in two new EphA4 crystal structures provide a unique insight into the ..
  10. Rathor L, Pandey R. Age-induced diminution of free radicals by Boeravinone B in Caenorhabditis elegans. Exp Gerontol. 2018;111:94-106 pubmed publisher
    ..2) fused to green fluorescent protein (GFP), and it does so by modulating the stress-related signaling pathways (SEK-1) and transcription factors (SKN-1/Nrf and DAF-16/Foxo)...
  11. Takahashi I, Hama Y, Matsushima M, Hirotani M, Kano T, Hohzen H, et al. Identification of plasma microRNAs as a biomarker of sporadic Amyotrophic Lateral Sclerosis. Mol Brain. 2015;8:67 pubmed publisher
    ..b>EPHA4, a target gene linked to the nervous system which has also been reported to be a disease modifier of ALS, is the ..
  12. Li G, Wu C, Wang X, Meng J. Prevalence and characterization of methicillin susceptible Staphylococcus aureus ST398 isolates from retail foods. Int J Food Microbiol. 2015;196:94-7 pubmed publisher
    ..7%), lukED and seg (each 3.3%) were detected. None of isolates contained sea, sec, see, seh, sei, tst, eta, etb, sek-ser, seu, lukM, hlg, and hlgv genes...
  13. Husa A, Magić Å, Larsson M, Fornander T, Pérez Tenorio G. EPH/ephrin profile and EPHB2 expression predicts patient survival in breast cancer. Oncotarget. 2016;7:21362-80 pubmed publisher
    ..EPHA2, EPHA4, EFNB1, EFNB2, EPHB2 and EPHB6 were significantly correlated with the cluster groups and particularly EPHB2 was an ..
  14. Gordon K, Kochkodan J, Blatt H, Lin S, Kaplan N, Johnston A, et al. Alteration of the EphA2/Ephrin-A signaling axis in psoriatic epidermis. J Invest Dermatol. 2013;133:712-722 pubmed publisher
    ..increased mRNA transcripts for several members of this RTK family in plaques, including the EphA1, EphA2, and EphA4 subtypes prominently expressed by keratinocytes...
  15. You X, Xi J, Liu W, Cao Y, Tang W, Zhang X, et al. 2,2',4,4'-tetrabromodiphenyl ether induces germ cell apoptosis through oxidative stress by a MAPK-mediated p53-independent pathway. Environ Pollut. 2018;242:887-893 pubmed publisher
    ..In addition, the apoptosis was blocked in mutants carrying mek-1, sek-1 or abl-1 loss-of-function alleles, but not in the p53/cep-1 deficient worms, suggesting that the mitogen-..
  16. Wang J, Du H, Nie Y, Wang Y, Dai H, Wang M, et al. Mitochondria and MAPK cascades modulate endosulfan-induced germline apoptosis in Caenorhabditis elegans. Toxicol Res (Camb). 2017;6:412-419 pubmed publisher
    ..The apoptotic effects of endosulfan were blocked in the mutants of jnk-1/JNK-MAPK, sek-1/MAP2K, and pmk-1/p38-MAPK, suggesting that these downstream genes play an essential role in endosulfan-..
  17. Wang D, Zhang L, Yong C, Shen M, Ali T, Shahid M, et al. Relationships among superantigen toxin gene profiles, genotypes, and pathogenic characteristics of Staphylococcus aureus isolates from bovine mastitis. J Dairy Sci. 2017;100:4276-4286 pubmed publisher
    ..0% each), followed by seo, tst, and etB (28.0% each), etA (24.0%), sem and sep (16.0% each), seb, sec, sed, and sek (12.0% each), and sea and seh genes (8.0% each); the seg, sej, and ser genes were present in 4.0% of the isolates...
  18. Sastalla I, Williams K, Anderson E, Myles I, Reckhow J, Espinoza Moraga M, et al. Molecular Typing of Staphylococcus aureus Isolated from Patients with Autosomal Dominant Hyper IgE Syndrome. Pathogens. 2017;6: pubmed publisher
    ..that expressed methicillin resistance, Panton-Valentine leukocidin (PVL), and staphylococcal enterotoxins K and Q (SEK, SEQ)...
  19. Khemiri M, Akrout Alhusain A, Abbassi M, El Ghaieb H, Santos Costa S, Belas A, et al. Clonal spread of methicillin-resistant Staphylococcus aureus-t6065-CC5-SCCmecV-agrII in a Libyan hospital. J Glob Antimicrob Resist. 2017;10:101-105 pubmed publisher
    ..genes (seb: 32, seo: 32, sei: 32, ser: 32, seu: 32, seg: 32, sej: 32, sed: 31, sen: 29, seh: 26, sec: 26, sea: 6, sek: 5), haemolysin (hla (32), hld (32), hlg (32)) and immune evasion cluster proteins (scn: 32, sak: 32) were relevant...
  20. Petschner P, Tamasi V, Adori C, Kirilly E, Ando R, Tothfalusi L, et al. Gene expression analysis indicates reduced memory and cognitive functions in the hippocampus and increase in synaptic reorganization in the frontal cortex 3 weeks after MDMA administration in Dark Agouti rats. BMC Genomics. 2018;19:580 pubmed publisher
    ..gene sets in the hippocampus, parallel to the downregulation of CaMK II subunits, glutamate-, CB1 cannabinoid- and EphA4, EphA5, EphA6 receptors...
  21. Jeong D, Lee D, Hwang S, Lee Y, Lee J, Seo M, et al. Mitochondrial chaperone HSP-60 regulates anti-bacterial immunity via p38 MAP kinase signaling. EMBO J. 2017;36:1046-1065 pubmed publisher
    ..Further, cytosol-localized HSP-60 physically binds and stabilizes SEK-1/MAP kinase kinase 3, which in turn up-regulates p38 MAP kinase and increases immunity...
  22. Oh C, Park S, Kim J, Moon Y. Non-mutagenic Suppression of Enterocyte Ferroportin 1 by Chemical Ribosomal Inactivation via p38 Mitogen-activated Protein Kinase (MAPK)-mediated Regulation: EVIDENCE FOR ENVIRONMENTAL HEMOCHROMATOSIS. J Biol Chem. 2016;291:19858-72 pubmed publisher
    ..iron accumulation in Caenorhabditis elegans as a simplified in vivo model for gut nutrition uptake was dependent on SEK-1, a p38 kinase activator, leading to suppression of FPN-1.1 expression and iron accumulation...
  23. Begum N, Stephens S, Schoeman O, Fraschke A, Kirsch B, Briere J, et al. Cost-effectiveness Analysis of Rivaroxaban in the Secondary Prevention of Acute Coronary Syndromes in Sweden. Cardiol Ther. 2015;4:131-53 pubmed publisher
    ..in survival and quality-adjusted life years (QALYs), yielding an incremental cost per QALY of 71,246 Swedish Krona (SEK) (€8045). The outcomes were robust to changes in inputs...
  24. Jattujan P, Chalorak P, Siangcham T, Sangpairoj K, Nobsathian S, Poomtong T, et al. Holothuria scabra extracts possess anti-oxidant activity and promote stress resistance and lifespan extension in Caenorhabditis elegans. Exp Gerontol. 2018;110:158-171 pubmed publisher
    ..1, jnk-1, sek-1, and osr-1 mutants, suggesting that these genetic pathways are involved in mediating the anti-ageing effects of ..
  25. Nirasawa S, Kobayashi D, Kondoh T, Kuribayashi K, Tanaka M, Yanagihara N, et al. Significance of serine threonine tyrosine kinase 1 as a drug resistance factor and therapeutic predictor in acute leukemia. Int J Oncol. 2014;45:1867-74 pubmed publisher
    ..Three tyrosine kinases (EphA4, FLT4 and STK31), two NF-κB inducers (MAPK4 and TNF-RSF11A), and two genes essential for stem cell replication (..
  26. Peuckert C, Aresh B, Holenya P, Adams D, Sreedharan S, Porthin A, et al. Multimodal Eph/Ephrin signaling controls several phases of urogenital development. Kidney Int. 2016;90:373-388 pubmed publisher
    ..These processes were disturbed in EphA4/EphB2 compound knockout mice and were accompanied by decreased ERK-2 phosphorylation...
  27. Kuo H, Liu F. Valproic acid induces aberrant development of striatal compartments and corticostriatal pathways in a mouse model of autism spectrum disorder. FASEB J. 2017;31:4458-4471 pubmed publisher
    ..75 treatment altered the expression of ephrinA5 and EphA4, two molecules that are related to compartmental segregation. In the VPAE12...
  28. Bergion V, Lindhe A, Sokolova E, Rosen L. Risk-based cost-benefit analysis for evaluating microbial risk mitigation in a drinking water system. Water Res. 2018;132:111-123 pubmed publisher
    ..divided evenly over the studied time horizon and reduced microbial risks posed to animals), estimated at 800-1200 SEK (€100-150) per connected on-site wastewater treatment system per year, were included...
  29. Collinson J, Lindström N, Neves C, Wallace K, Meharg C, Charles R, et al. The developmental and genetic basis of 'clubfoot' in the peroneal muscular atrophy mutant mouse. Development. 2018;145: pubmed publisher
    ..Genetic and molecular analyses showed that the mutation acts in the EphA4-Limk1-Cfl1/cofilin-actin pathway to modulate growth cone extension/collapse...
  30. Lai W, Wang B, Hu M, Hsu W, Her G, Liao Y. Ligand-dependent activation of EphA4 signaling regulates the proteolysis of amyloid precursor protein through a Lyn-mediated pathway. Mol Neurobiol. 2014;49:1055-68 pubmed publisher
    ..Here, we demonstrate that ligand-activated EphA4 signaling governs the proteostasis of C99, AICD, and A?, without significantly affecting ?-secretase activity...
  31. Wimo A, Jönsson L, Fratiglioni L, Sandman P, Gustavsson A, Sköldunger A, et al. The societal costs of dementia in Sweden 2012 - relevance and methodological challenges in valuing informal care. Alzheimers Res Ther. 2016;8:59 pubmed
    ..The societal costs of dementia in Sweden in 2012 were SEK 62.9 billion (approximately €7.2 billion, approximately US$9...
  32. Jendle J, Smith Palmer J, Delbaere A, De Portu S, Papo N, Valentine W, et al. Cost-Effectiveness Analysis of Sensor-Augmented Insulin Pump Therapy with Automated Insulin Suspension Versus Standard Insulin Pump Therapy in Patients with Type 1 Diabetes in Sweden. Diabetes Ther. 2017;8:1015-1030 pubmed publisher
    ..incremental cost-effectiveness ratios for the SAP with automated insulin suspension versus CSII of Swedish Krona (SEK) 139,795 [euros (EUR) 14,648] per QALY gained for patients at increased risk for hypoglycemia and SEK 251,896 (..
  33. Cashin P, Mahteme H, Syk I, Frodin J, Glimelius B, Graf W. Quality of life and cost effectiveness in a randomized trial of patients with colorectal cancer and peritoneal metastases. Eur J Surg Oncol. 2018;44:983-990 pubmed publisher
    ..8 QALYs in favor of the surgery arm (p=0.06) with an ICER per QALY gained at 310,000 SEK (EORTC-8D) or 362,000 SEK (SF-6D) corresponding to 26,700-31,200 GBP...
  34. Oki M, Yamamoto H, Taniguchi H, Adachi Y, Imai K, Shinomura Y. Overexpression of the receptor tyrosine kinase EphA4 in human gastric cancers. World J Gastroenterol. 2008;14:5650-6 pubmed
    To clarify the expression and role of Ephrin receptor A4 (EphA4) in gastric cancer in relation to clinicopathological characteristics and the expression of fibroblast growth factor receptor 1 (FGFR1) and ephrin ligands...
  35. Poitz D, Ende G, Stütz B, Augstein A, Friedrichs J, Brunssen C, et al. EphrinB2/EphA4-mediated activation of endothelial cells increases monocyte adhesion. Mol Immunol. 2015;68:648-56 pubmed publisher
    ..Previous studies point to a crucial role of the EphA4-receptor in the process of monocyte adhesion...
  36. Jönsen A, Hjalte F, Willim M, Carlsson K, Sjöwall C, Svenungsson E, et al. Direct and indirect costs for systemic lupus erythematosus in Sweden. A nationwide health economic study based on five defined cohorts. Semin Arthritis Rheum. 2016;45:684-90 pubmed publisher
    ..1-3.6, and mean annual sick leave was 123-148 days, all per patient. The total annual cost was 208,555 SEK ($33,369 = 22,941€), of which direct cost was 63,672kr ($10,188 = 7004€) and the indirect cost was 144,..
  37. Liu Q, Guo X, Que S, Yang X, Fan H, Liu M, et al. LncRNA RSU1P2 contributes to tumorigenesis by acting as a ceRNA against let-7a in cervical cancer cells. Oncotarget. 2017;8:43768-43781 pubmed publisher
    ..that RSU1P2 acts as a competitive endogenous RNA (ceRNA) through regulating the expression of IGF1R, N-myc and EphA4. The mechanism of this regulation is via competition for the shared microRNA let-7a...
  38. Wu B, De S, Kulinich A, Salem A, Koeppen J, Wang R, et al. Potent and Selective EphA4 Agonists for the Treatment of ALS. Cell Chem Biol. 2017;24:293-305 pubmed publisher
    ..Recent studies identified the receptor tyrosine kinase EphA4 as a disease-modifying gene that is critical for the progression of motor neuron degeneration...
  39. Ortega Riveros M, De la Pinta I, Marcos Arias C, Ezpeleta G, Quindos G, Eraso E. Usefulness of the Non-conventional Caenorhabditis elegans Model to Assess Candida Virulence. Mycopathologia. 2017;182:785-795 pubmed publisher
    ..A double mutant C. elegans AU37 strain (glp-4;sek-1) was infected with Candida by ingestion, and the analysis of nematode survival was performed in liquid medium ..
  40. Persson U, Norlin J. Multi-indication and Combination Pricing and Reimbursement of Pharmaceuticals: Opportunities for Improved Health Care through Faster Uptake of New Innovations. Appl Health Econ Health Policy. 2018;16:157-165 pubmed publisher
    ..of several cancer drugs was estimated for various indications based on a willingness-to-pay threshold of 1 million SEK (EUR 104,000) per QALY gained...
  41. Adaimy L, Chouery E, Megarbane H, Mroueh S, Delague V, Nicolas E, et al. Mutation in WNT10A is associated with an autosomal recessive ectodermal dysplasia: the odonto-onycho-dermal dysplasia. Am J Hum Genet. 2007;81:821-8 pubmed
  42. Gyllencreutz L, Björnstig J, Rolfsman E, Saveman B. Outdoor pedestrian fall-related injuries among Swedish senior citizens--injuries and preventive strategies. Scand J Caring Sci. 2015;29:225-33 pubmed publisher
    ..2 million EUR (55 million SEK). Environmental factors such as ice were the most commonly described cause of the injury incident...
  43. Chao G, Bao G, Cao Y, Yan W, Wang Y, Zhang X, et al. Prevalence and diversity of enterotoxin genes with genetic background of Staphylococcus aureus isolates from different origins in China. Int J Food Microbiol. 2015;211:142-7 pubmed publisher
    ..05). We identified two important gene clusters, sea-sek-seq, which is closely related to hospital-acquired (HA) methicillin-resistant Staphylococcus aureus (MRSA)-III, and ..
  44. Sun Y, QIAN J, Lu M, Xu H. Lower and reduced expression of EphA4 is associated with advanced TNM stage, lymph node metastasis, and poor survival in breast carcinoma. Pathol Int. 2016;66:506-10 pubmed publisher
    The expression of EphA4 has been well documented in the development of nerve and in certain types of human cancer. Few studies of EphA4, however, have focused on breast carcinoma...
  45. Dines M, Grinberg S, Vassiliev M, Ram A, Tamir T, Lamprecht R. The roles of Eph receptors in contextual fear conditioning memory formation. Neurobiol Learn Mem. 2015;124:62-70 pubmed publisher
    ..Toward that end, we examined the roles of EphB2 and EphA4 receptors, key regulators of synaptic functions, in fear conditioning memory formation...
  46. Battisti J, Watson L, Naung M, Drobish A, Voronina E, Minnick M. Analysis of the Caenorhabditis elegans innate immune response to Coxiella burnetii. Innate Immun. 2017;23:111-127 pubmed publisher
    ..burnetii. sek-1(-) MAP kinase mutant nematodes succumbed to infection faster, suggesting that this signaling pathway plays a role ..
  47. Feng L, Shu Y, Wu Q, Liu T, Long H, Yang H, et al. EphA4 may contribute to microvessel remodeling in the hippocampal CA1 and CA3 areas in a mouse model of temporal lobe epilepsy. Mol Med Rep. 2017;15:37-46 pubmed publisher
    ..of hippocampus in a mouse model of temporal lobe epilepsy (TLE), and act through alleviating ephrin receptor A4 (EphA4)?mediated neurogenesis and angiogenesis...
  48. Wang J, Leng X, Wang G, Wan X, Cao H. The construction of intrahepatic cholangiocarcinoma model in zebrafish. Sci Rep. 2017;7:13419 pubmed publisher
    ..Moreover, three potential biomarker genes were hypomethylated in the tumorigenesis of ICC: ehf, epha4 and itgb6...
  49. Li W, Wang D, Wang D. Regulation of the Response of Caenorhabditis elegans to Simulated Microgravity by p38 Mitogen-Activated Protein Kinase Signaling. Sci Rep. 2018;8:857 pubmed publisher
    ..Simulated microgravity treatment significantly increased the transcriptional expressions of genes (pmk-1, sek-1, and nsy-1) encoding core p38 MAPK signaling pathway and the expression of phosphorylated PMK-1/p38 MAPK...
  50. Tedroff K, Befrits G, Tedroff C, Gantelius S. To switch from Botox to Dysport in children with CP, a real world, dose conversion, cost-effectiveness study. Eur J Paediatr Neurol. 2018;22:412-418 pubmed publisher
    ..The drug-cost per treatment was 4029 SEK for Botox and 2380 SEK in the case of Dysport...
  51. Ng Y, Or T, Ip N. Plant alkaloids as drug leads for Alzheimer's disease. Neurochem Int. 2015;89:260-70 pubmed publisher
    ..a known neuroprotective alkaloid, was recently discovered by in silico screening as an inhibitor of EphA4, a novel target for AD...
  52. Verhoef T, Redekop W, Langenskiöld S, Kamali F, Wadelius M, Burnside G, et al. Cost-effectiveness of pharmacogenetic-guided dosing of warfarin in the United Kingdom and Sweden. Pharmacogenomics J. 2016;16:478-84 pubmed publisher
    ..Incremental lifetime costs were £26 and 382 Swedish kronor (SEK) and incremental QALYs were 0.0039 and 0.0015 in the United Kingdom and Sweden, respectively...
  53. Gyllensten H, Wiberg M, Alexanderson K, Norlund A, Friberg E, Hillert J, et al. Costs of illness of multiple sclerosis in Sweden: a population-based register study of people of working age. Eur J Health Econ. 2018;19:435-446 pubmed publisher
    ..The estimated COI of all the MS patients were SEK 3950 million, of which 75% were indirect costs...
  54. Inokuchi M, Nakagawa M, Baogok N, Takagi Y, Tanioka T, Gokita K, et al. Prognostic Significance of High EphA1-4 Expression Levels in Locally Advanced Gastric Cancer. Anticancer Res. 2018;38:1685-1693 pubmed
    ..0098), and high expression levels of EPHA1 and 4 tended to be associated with poor survival (p=0.050, p=0.052). EphA 1, 2, and 4 may play key roles in recurrence and survival in patients with advanced gastric cancer. ..
  55. Tan W, Yao W, Hu R, Lv Y, Wan L, Zhang C, et al. Alleviating neuropathic pain mechanical allodynia by increasing Cdh1 in the anterior cingulate cortex. Mol Pain. 2015;11:56 pubmed publisher
    ..AMPA receptor GluR1 subunit protein level was up-regulated on the membrane through a pathway that involves EphA4 mediated by APC/C-Cdh1, 3 and 7 days after SNI surgery...
  56. Freyburger M, Pierre A, Paquette G, Bélanger Nelson E, Bedont J, Gaudreault P, et al. EphA4 is Involved in Sleep Regulation but Not in the Electrophysiological Response to Sleep Deprivation. Sleep. 2016;39:613-24 pubmed publisher
    ..The EphA4 tyrosine kinase receptor is a cell adhesion protein regulating synaptic plasticity...
  57. Adhikari R, Haudenschild C, Sterba P, Sahandi S, Enterlein S, Holtsberg F, et al. Development of a novel multiplex electrochemiluminescent-based immunoassay for quantification of human serum IgG against 10 Staphylococcus aureus toxins. J Immunol Methods. 2016;430:33-42 pubmed publisher
    ..subunits, and 3) enterotoxin/superantigens - Staphylococcal enterotoxins A (SEA), B (SEB), C1 (SEC1), D (SED), K (SEK) and Toxic shock syndrome toxin-1 (TSST-1)...
  58. Wallace M, Harris J, Brubaker D, Klotz C, Gabriele M. Graded and discontinuous EphA-ephrinB expression patterns in the developing auditory brainstem. Hear Res. 2016;335:64-75 pubmed publisher
    ..Here we utilize X-Gal staining approaches in lacZ mutant mice (ephrin-B2, -B3, and EphA4) to reveal EphA-ephrinB expression patterns in the nascent IC during the period of projection shaping that ..
  59. Wang Y, Liu Z, Yao B, Dou C, Xu M, Xue Y, et al. Long non-coding RNA TUSC7 acts a molecular sponge for miR-10a and suppresses EMT in hepatocellular carcinoma. Tumour Biol. 2016;37:11429-41 pubmed publisher
    ..Furthermore, we found that TUSC7 could decrease the expression of Eph tyrosine kinase receptor A4 (EphA4), a downstream target of miR-10a as well as an EMT suppressor, through TUSC7-miR-10a-EphA4 axis...
  60. Iiizumi M, Hosokawa M, Takehara A, Chung S, Nakamura T, Katagiri T, et al. EphA4 receptor, overexpressed in pancreatic ductal adenocarcinoma, promotes cancer cell growth. Cancer Sci. 2006;97:1211-6 pubmed
    ..up-regulated genes identified in PDAC cells, we herein focused on one tyrosine kinase receptor, Eph receptor A4 (EphA4), as a molecular target for PDAC therapy...
  61. Karidis N, Giaginis C, Tsourouflis G, Alexandrou P, Delladetsima I, Theocharis S. Eph-A2 and Eph-A4 expression in human benign and malignant thyroid lesions: an immunohistochemical study. Med Sci Monit. 2011;17:BR257-65 pubmed
    ..Further studies conducted on cohorts including a higher proportion of patients with advanced nodal and metastatic disease are recommended to draw definite conclusions on the clinical significance of Eph proteins in thyroid neoplasia. ..
  62. Fujiwara H, Nishioka Y, Matsumoto H, Suginami K, Horie A, Tani H, et al. Eph-ephrin A system regulates human choriocarcinoma-derived JEG-3 cell invasion. Int J Gynecol Cancer. 2013;23:576-82 pubmed publisher
    ..These findings suggest that Eph-ephrin interaction plays some role in the regulation of choriocarcinoma invasion in cooperation with integrins. ..
  63. Ellis C, Kasmi F, Ganju P, Walls E, Panayotou G, Reith A. A juxtamembrane autophosphorylation site in the Eph family receptor tyrosine kinase, Sek, mediates high affinity interaction with p59fyn. Oncogene. 1996;12:1727-36 pubmed
    ..have now identified two in vitro autophosphorylation sites within the juxtamembrane domain of the Eph family member Sek, and a candidate binding protein for the activated Sek kinase...
  64. Zhou R. The Eph family receptors and ligands. Pharmacol Ther. 1998;77:151-81 pubmed
    ..The best known function is their role in the guidance of migration of axons and cells in the nervous system through repulsive interactions. They may also play a role in angiogenesis, tissue patterning, and tumor formation. ..
  65. Prevost N, Woulfe D, Tanaka T, Brass L. Interactions between Eph kinases and ephrins provide a mechanism to support platelet aggregation once cell-to-cell contact has occurred. Proc Natl Acad Sci U S A. 2002;99:9219-24 pubmed
    ..The results show that human platelets express EphA4 and EphB1, and the ligand, ephrinB1...
  66. Merrill A, Bochukova E, Brugger S, Ishii M, Pilz D, Wall S, et al. Cell mixing at a neural crest-mesoderm boundary and deficient ephrin-Eph signaling in the pathogenesis of craniosynostosis. Hum Mol Genet. 2006;15:1319-28 pubmed
    ..This provides genetic evidence that Twist1, Msx2 and Efna4 function together in boundary formation and the pathogenesis of coronal synostosis...
  67. Tournoij E, Koekman C, Du V, Roest M, Ruijtenbeek R, Moll F, et al. The platelet P2Y12 receptor contributes to granule secretion through Ephrin A4 receptor. Platelets. 2012;23:617-25 pubmed publisher
    ..Blockade of P2Y(1/12) inhibited phosphorylation of EphA4- and EphB1-peptides on micro-arrays...
  68. Frugier T, Conquest A, McLean C, Currie P, Moses D, Goldshmit Y. Expression and activation of EphA4 in the human brain after traumatic injury. J Neuropathol Exp Neurol. 2012;71:242-50 pubmed publisher
    ..We analyzed EphA4 expression and activation in postmortem brain tissue from 19 patients who died after acute closed head injury and ..
  69. Nugent A, Park J, Wei Y, Tenney A, Gilette N, DeLisle M, et al. Mutant α2-chimaerin signals via bidirectional ephrin pathways in Duane retraction syndrome. J Clin Invest. 2017;127:1664-1682 pubmed publisher
    ..Findings from Chn1KI/KI Epha4KO/KO mice demonstrated that mutant α2-chimaerin and EphA4 have different genetic interactions in distinct motor neuron pools: abducens neurons use bidirectional ephrin ..
  70. Tuft B, Xu L, Leigh B, Lee D, Guymon C, Hansen M. Photopolymerized micropatterns with high feature frequencies overcome chemorepulsive borders to direct neurite growth. J Tissue Eng Regen Med. 2017;: pubmed publisher
    ..The micropatterned substrates are then modified with repulsive chemical borders between laminin and either EphA4-Fc or tenascin C that compete with the surface microfeatures to direct neurite growth...
  71. Aasheim H, Terstappen L, Logtenberg T. Regulated expression of the Eph-related receptor tyrosine kinase Hek11 in early human B lymphopoiesis. Blood. 1997;90:3613-22 pubmed
    ..This population was found to harbor transcripts of the Hek8 and Hek11 members of this gene family...
  72. Janis L, Cassidy R, Kromer L. Ephrin-A binding and EphA receptor expression delineate the matrix compartment of the striatum. J Neurosci. 1999;19:4962-71 pubmed
    ..EphA RTKs reveals that the two different ligand binding patterns strictly match the mRNA expression patterns of EphA4 and EphA7...
  73. Wilkinson D. Multiple roles of EPH receptors and ephrins in neural development. Nat Rev Neurosci. 2001;2:155-64 pubmed
    ..Eph receptor tyrosine kinases and their ephrin ligands are key players in controlling these cell movements in many tissues and at multiple stages of patterning. ..
  74. van Doorn R, Dijkman R, Vermeer M, Out Luiting J, van der Raaij Helmer E, Willemze R, et al. Aberrant expression of the tyrosine kinase receptor EphA4 and the transcription factor twist in Sézary syndrome identified by gene expression analysis. Cancer Res. 2004;64:5578-86 pubmed
    ..Moreover, the tyrosine kinase receptor EphA4 and the potentially oncogenic transcription factor Twist were highly and selectively expressed in T cells of ..
  75. Yokote H, Fujita K, Jing X, Sawada T, Liang S, Yao L, et al. Trans-activation of EphA4 and FGF receptors mediated by direct interactions between their cytoplasmic domains. Proc Natl Acad Sci U S A. 2005;102:18866-71 pubmed
    ..has shown that the juxtamembrane region of FGF receptor 3 (FGFR3) interacts with the cytoplasmic domain of EphA4, which is a member of the largest family of receptor tyrosine kinases...
  76. Sawada T, Jing X, Zhang Y, Shimada E, Yokote H, Miyajima M, et al. Ternary complex formation of EphA4, FGFR and FRS2? plays an important role in the proliferation of embryonic neural stem/progenitor cells. Genes Cells. 2010;15:297-311 pubmed publisher
    b>EphA4 belongs to a superfamily of receptor tyrosine kinases and interacts with several molecules including fibroblast growth factor receptors (FGFRs) as we reported earlier...
  77. Saintigny P, Peng S, Zhang L, Sen B, Wistuba I, Lippman S, et al. Global evaluation of Eph receptors and ephrins in lung adenocarcinomas identifies EphA4 as an inhibitor of cell migration and invasion. Mol Cancer Ther. 2012;11:2021-32 pubmed publisher
    ..Functional studies to assess the role of Eph receptor A4 (EphA4) were carried out in vitro...
  78. de Marcondes P, Morgado Díaz J. The Role of EphA4 Signaling in Radiation-Induced EMT-Like Phenotype in Colorectal Cancer Cells. J Cell Biochem. 2017;118:442-445 pubmed publisher
    ..we have demonstrated that the PI3K/AKT, Wnt/β-catenin signaling pathways as well as ERK1/2 downstream of EPHA4 receptor activation, play an important role in the regulation of events related with the EMT development, which ..
  79. Allina D, Andreeva Y, Zavalishina L, Moskvina L, Frank G. [Estimation of the diagnostic potential of APOD, PTOV1, and EPHA4 for prostatic neoplasms]. Arkh Patol. 2016;78:9-14 pubmed publisher
    ..to estimate the diagnostic and prognostic value of the expression of PTOV1, APOD, and EPHA4 in prostatic neoplasias...
  80. Hoyt J, Wilson S, Kasa M, Rise J, Topalidou I, Ailion M. The SEK-1 p38 MAP Kinase Pathway Modulates Gq Signaling in Caenorhabditis elegans. G3 (Bethesda). 2017;7:2979-2989 pubmed publisher
    ..One of the suppressors is an allele of sek-1, which encodes a mitogen-activated protein kinase kinase (MAPKK) in the p38 MAPK pathway...
  81. Huang T, Zhao Y, Jiang L, Li X, Liu Y, Sun Y, et al. SORLA attenuates EphA4 signaling and amyloid ?-induced neurodegeneration. J Exp Med. 2017;214:3669-3685 pubmed publisher
    ..Here, we show that SORLA interacts with the EphA4 receptor tyrosine kinase and attenuates ephrinA1 ligand-induced EphA4 clustering and activation to limit ..
  82. Bergemann A, Zhang L, Chiang M, Brambilla R, Klein R, Flanagan J. Ephrin-B3, a ligand for the receptor EphB3, expressed at the midline of the developing neural tube. Oncogene. 1998;16:471-80 pubmed
    ..The isolation of this ligand may help to elucidate the molecular basis of patterning activities at the neural tube midline. ..
  83. Wilkinson D. Eph receptors and ephrins: regulators of guidance and assembly. Int Rev Cytol. 2000;196:177-244 pubmed
    ..Eph receptors and ephrins have thus emerged as key regulators of the repulsion and adhesion of cells that underlie the establishment, maintenance, and remodeling of patterns of cellular organization. ..
  84. Takemoto M, Fukuda T, Sonoda R, Murakami F, Tanaka H, Yamamoto N. Ephrin-B3-EphA4 interactions regulate the growth of specific thalamocortical axon populations in vitro. Eur J Neurosci. 2002;16:1168-72 pubmed
    ..In situ hybridization and immunohistochemistry showed that EphA4, a receptor of ephrin-B3, was expressed in the lateral thalamus (visual and somaotosensory thalamus) of the ..
  85. Tanasic S, Mattusch C, Wagner E, Eder M, Rupprecht R, Rammes G, et al. Desipramine targets astrocytes to attenuate synaptic plasticity via modulation of the ephrinA3/EphA4 signalling. Neuropharmacology. 2016;105:154-163 pubmed publisher
    ..analyse a regulator of LTP located at the astrocyte-neuron interface in the stratum radiatum, namely the ephrinA3/EphA4 signalling pathway...
  86. Rothe M, Kanwal N, Dietmann P, Seigfried F, Hempel A, Schütz D, et al. An Epha4/Sipa1l3/Wnt pathway regulates eye development and lens maturation. Development. 2017;144:321-333 pubmed publisher
    ..We found a direct interaction between Sipa1l3 and Epha4, building a functional platform for proper ocular development...
  87. Zhao J, Boyd A, Bartlett P. The identification of a novel isoform of EphA4 and ITS expression in SOD1G93A mice. Neuroscience. 2017;347:11-21 pubmed publisher
    ..Mutations in more than 20 genes, including full-length EphA4 (EphA4-FL), have been implicated in this pathogenesis...
  88. Sawada T, Arai D, Jing X, Miyajima M, Frank S, Sakaguchi K. Molecular interactions of EphA4, growth hormone receptor, Janus kinase 2, and signal transducer and activator of transcription 5B. PLoS ONE. 2017;12:e0180785 pubmed publisher
    We previously reported that EphA4, a member of the Eph family of receptor tyrosine kinases, is an important modulator of growth hormone (GH) signaling, leading to augmented synthesis of insulin-like growth factor 1 (IGF1) for postnatal ..
  89. Katori S, Noguchi Katori Y, Itohara S, Iwasato T. Spinal RacGAP α-Chimaerin Is Required to Establish the Midline Barrier for Proper Corticospinal Axon Guidance. J Neurosci. 2017;37:7682-7699 pubmed publisher
    ..Strikingly, Sp-Chn1KO mice had breaks (holes) in the ephrinB3(+) spinal midline barrier and EphA4(+) CST axons aberrantly crossed the midline through these holes...
  90. Dong Y, Liu Y, Jiang A, Li R, Yin M, Wang Y. MicroRNA-335 suppresses the proliferation, migration, and invasion of breast cancer cells by targeting EphA4. Mol Cell Biochem. 2018;439:95-104 pubmed publisher
    ..In addition, emerging evidence indicates that erythropoietin-producing hepatocellular A4 (EphA4) is implicated in cancer cell proliferation, migration, and invasion...
  91. Liang B, Huang Y, Chen Y, Dong H, Mai J, Xie Y, et al. Antimicrobial resistance and prevalence of CvfB, SEK and SEQ genes among Staphylococcus aureus isolates from paediatric patients with bloodstream infections. Exp Ther Med. 2017;14:5143-5148 pubmed publisher
    ..genes conserved virulence factor B (CvfB), staphylococcal enterotoxin Q (SEQ) and staphylococcal enterotoxin K (SEK) among S...
  92. Prevost N, Woulfe D, Tognolini M, Tanaka T, Jian W, Fortna R, et al. Signaling by ephrinB1 and Eph kinases in platelets promotes Rap1 activation, platelet adhesion, and aggregation via effector pathways that do not require phosphorylation of ephrinB1. Blood. 2004;103:1348-55 pubmed
    We have previously shown that platelets express 2 receptor tyrosine kinases, EphA4 and EphB1, and the Eph kinase ligand, ephrinB1, and proposed that transcellular Eph/ephrin interactions made possible by the onset of platelet aggregation ..