EphA2

Summary

Gene Symbol: EphA2
Description: EPH receptor A2
Alias: ARCC2, CTPA, CTPP1, CTRCT6, ECK, ephrin type-A receptor 2, epithelial cell receptor protein tyrosine kinase, soluble EPHA2 variant 1, tyrosine-protein kinase receptor ECK
Species: human
Products:     EphA2

Top Publications

  1. Sulman E, Tang X, Allen C, Biegel J, Pleasure D, Brodeur G, et al. ECK, a human EPH-related gene, maps to 1p36.1, a common region of alteration in human cancers. Genomics. 1997;40:371-4 pubmed
    Mouse eck, a member of the EPH gene family, has been mapped to mouse chromosome 4...
  2. Hess A, Seftor E, Gruman L, Kinch M, Seftor R, Hendrix M. VE-cadherin regulates EphA2 in aggressive melanoma cells through a novel signaling pathway: implications for vasculogenic mimicry. Cancer Biol Ther. 2006;5:228-33 pubmed
    ..This study contributes new observations demonstrating that VE-cadherin can regulate the expression of EphA2 at the cell membrane by mediating its ability to become phosphorylated through interactions with its membrane ..
  3. Shiels A, Bennett T, Knopf H, Maraini G, Li A, Jiao X, et al. The EPHA2 gene is associated with cataracts linked to chromosome 1p. Mol Vis. 2008;14:2042-55 pubmed
    ..2842G>T) in exon 17 of the gene coding for Eph-receptor type-A2 (EPHA2) that cosegregated with the disease...
  4. Ruiz J, Robertson E. The expression of the receptor-protein tyrosine kinase gene, eck, is highly restricted during early mouse development. Mech Dev. 1994;46:87-100 pubmed
    ..Here, we analyze the expression of eck, a member of the eph family of R-PTKs, during gastrulation and early organogenesis by in situ hybridization...
  5. Pratt R, Kinch M. Activation of the EphA2 tyrosine kinase stimulates the MAP/ERK kinase signaling cascade. Oncogene. 2002;21:7690-9 pubmed
    ..Recent studies in our laboratory and others have demonstrated that the EphA2 receptor tyrosine kinase critically regulates tumor cell growth, migration and invasiveness...
  6. Miao H, Li D, Mukherjee A, Guo H, Petty A, Cutter J, et al. EphA2 mediates ligand-dependent inhibition and ligand-independent promotion of cell migration and invasion via a reciprocal regulatory loop with Akt. Cancer Cell. 2009;16:9-20 pubmed publisher
    Both pro- and antioncogenic properties have been attributed to EphA2 kinase. We report that a possible cause for this apparent paradox is diametrically opposite roles of EphA2 in regulating cell migration and invasion...
  7. Yang J, Luo J, Zhou P, Fan Q, Luo Y, Lu Y. Association of the ephreceptor tyrosinekinase-type A2 (EPHA2) gene polymorphism rs3754334 with age-related cataract risk: a meta-analysis. PLoS ONE. 2013;8:e71003 pubmed publisher
    ..clinical studies have assessed the association of various polymorphisms on the ephreceptor tyrosinekinase-type A2 (EPHA2) with the risk for age-related cataract in populations of different ethnic/racial backgrounds, but inconsistent ..
  8. Kawabe M, Mandic M, Taylor J, Vasquez C, Wesa A, Neckers L, et al. Heat shock protein 90 inhibitor 17-dimethylaminoethylamino-17-demethoxygeldanamycin enhances EphA2+ tumor cell recognition by specific CD8+ T cells. Cancer Res. 2009;69:6995-7003 pubmed publisher
    b>EphA2, a member of the receptor tyrosine kinase family, is commonly expressed by a broad range of cancer types, where its level of (over)expression correlates with poor clinical outcome...
  9. Wilkinson D. Multiple roles of EPH receptors and ephrins in neural development. Nat Rev Neurosci. 2001;2:155-64 pubmed
    ..Eph receptor tyrosine kinases and their ephrin ligands are key players in controlling these cell movements in many tissues and at multiple stages of patterning. ..

More Information

Publications84

  1. Tanaka M, Kamata R, Sakai R. EphA2 phosphorylates the cytoplasmic tail of Claudin-4 and mediates paracellular permeability. J Biol Chem. 2005;280:42375-82 pubmed
    Eph receptors and ephrin ligands are widely expressed in epithelial cells and mediate cell-cell interaction. EphA2 is expressed in various cancer tissues and cell lines...
  2. Nakamura R, Kataoka H, Sato N, Kanamori M, Ihara M, Igarashi H, et al. EPHA2/EFNA1 expression in human gastric cancer. Cancer Sci. 2005;96:42-7 pubmed
    ..A recent report, however, indicated that stimulation of the EPHA2 receptor ligand, ephrinA1 (EFNA1), inhibits the growth of EPHA2-expressing breast cancer...
  3. Zelinski D, Zantek N, Walker Daniels J, Peters M, Taparowsky E, Kinch M. Estrogen and Myc negatively regulate expression of the EphA2 tyrosine kinase. J Cell Biochem. 2002;85:714-20 pubmed
    ..High levels of the EphA2 tyrosine kinase are consistently found in the most aggressive breast cancer cells, and EphA2 overexpression can ..
  4. Taddei M, Parri M, Angelucci A, Bianchini F, Marconi C, Giannoni E, et al. EphA2 induces metastatic growth regulating amoeboid motility and clonogenic potential in prostate carcinoma cells. Mol Cancer Res. 2011;9:149-60 pubmed publisher
    b>EphA2 kinase regulates cell shape, adhesion, and motility and is frequently overexpressed in several cancers, including melanoma, prostate, breast, and colon cancers and lung carcinoma...
  5. Baeten C, Hillen F, Pauwels P, De Bruine A, Baeten C. Prognostic role of vasculogenic mimicry in colorectal cancer. Dis Colon Rectum. 2009;52:2028-35 pubmed publisher
    ..PCR on human colorectal carcinoma material showed evidence for vasculogenic mimicry with overexpression of EPHA2 and LAMC2, known to be important for the tube-forming capacity of melanoma tumor cells...
  6. Faoro L, Singleton P, Cervantes G, Lennon F, Choong N, Kanteti R, et al. EphA2 mutation in lung squamous cell carcinoma promotes increased cell survival, cell invasion, focal adhesions, and mammalian target of rapamycin activation. J Biol Chem. 2010;285:18575-85 pubmed publisher
    Non-small cell lung cancer (NSCLC) has a poor prognosis and improved therapies are needed. Expression of EphA2 is increased in NSCLC metastases...
  7. Abraham S, Knapp D, Cheng L, Snyder P, Mittal S, Bangari D, et al. Expression of EphA2 and Ephrin A-1 in carcinoma of the urinary bladder. Clin Cancer Res. 2006;12:353-60 pubmed
    The EphA2 receptor tyrosine kinase is believed to play a role in tumor growth and metastasis. The clinical significance of the expression of EphA2 was observed in breast, prostate, colon, skin, cervical, ovarian, and lung cancers...
  8. Ogawa K, Pasqualini R, Lindberg R, Kain R, Freeman A, Pasquale E. The ephrin-A1 ligand and its receptor, EphA2, are expressed during tumor neovascularization. Oncogene. 2000;19:6043-52 pubmed
    ..By immunohistochemistry, the ephrin-A1 ligand and one of its receptors, EphA2, were detected throughout tumor vasculature...
  9. Zhuang G, Brantley Sieders D, Vaught D, Yu J, Xie L, Wells S, et al. Elevation of receptor tyrosine kinase EphA2 mediates resistance to trastuzumab therapy. Cancer Res. 2010;70:299-308 pubmed publisher
    ..In this study, we provide evidence that elevated level of the receptor tyrosine kinase Eph receptor A2 (EphA2) is an important contributor to trastuzumab resistance...
  10. Zhang G, Njauw C, Park J, Naruse C, Asano M, Tsao H. EphA2 is an essential mediator of UV radiation-induced apoptosis. Cancer Res. 2008;68:1691-6 pubmed publisher
    ..In a recent global screen of UVR response genes in melanocytes, we identified the receptor tyrosine kinase EPHA2. Using a combination of genetic and pharmacologic approaches, we set out to investigate the upstream regulation of ..
  11. Ganju P, Shigemoto K, Brennan J, Entwistle A, Reith A. The Eck receptor tyrosine kinase is implicated in pattern formation during gastrulation, hindbrain segmentation and limb development. Oncogene. 1994;9:1613-24 pubmed
    ..for additional receptor tyrosine kinases expressed during mouse embryogenesis we cloned the murine homolog of Eck, a member of the Eph subfamily, that maps to the distal region of mouse chromosome 4...
  12. Wykosky J, Gibo D, Stanton C, Debinski W. Interleukin-13 receptor alpha 2, EphA2, and Fos-related antigen 1 as molecular denominators of high-grade astrocytomas and specific targets for combinatorial therapy. Clin Cancer Res. 2008;14:199-208 pubmed publisher
    We investigated the expression of interleukin-13 receptor alpha2 (IL-13R alpha 2), EphA2, and Fos-related antigen 1 (Fra-1) in astrocytomas and normal brain...
  13. de Saint Vis B, Bouchet C, Gautier G, Valladeau J, Caux C, Garrone P. Human dendritic cells express neuronal Eph receptor tyrosine kinases: role of EphA2 in regulating adhesion to fibronectin. Blood. 2003;102:4431-40 pubmed
    ..showed that DCs derived from CD34+ progenitors, but not from monocytes, expressed several receptors, in particular EphA2, EphA4, EphA7, EphB1, and EphB3 mRNA...
  14. Dave A, Laurie K, Staffieri S, Taranath D, Mackey D, Mitchell P, et al. Mutations in the EPHA2 gene are a major contributor to inherited cataracts in South-Eastern Australia. PLoS ONE. 2013;8:e72518 pubmed publisher
    ..Recently, mutations in the receptor tyrosine kinase gene, EPHA2, have been found to cause congenital cataract in six different families...
  15. Lu C, Shahzad M, Wang H, Landen C, Kim S, Allen J, et al. EphA2 overexpression promotes ovarian cancer growth. Cancer Biol Ther. 2008;7:1098-103 pubmed
    Silencing EphA2 has been shown to result in anti-tumor efficacy. However, it is not known whether increasing EphA2 expression specifically results in increased tumor growth and progression...
  16. Park J, Son A, Hua R, Wang L, Zhang X, Zhou R. Human cataract mutations in EPHA2 SAM domain alter receptor stability and function. PLoS ONE. 2012;7:e36564 pubmed publisher
    ..In recent studies, several mutations in the cytoplasmic sterile-?-motif (SAM) domain of human EPHA2 on chromosome 1p36 have been associated with hereditary cataracts in several families...
  17. Gopal U, Bohonowych J, Lema Tome C, Liu A, Garrett Mayer E, Wang B, et al. A novel extracellular Hsp90 mediated co-receptor function for LRP1 regulates EphA2 dependent glioblastoma cell invasion. PLoS ONE. 2011;6:e17649 pubmed publisher
    ..The receptor tyrosine kinase EphA2 is overexpressed in the majority of GBM specimens and is a critical mediator of GBM invasiveness through its AKT ..
  18. Wang Y, Ota S, Kataoka H, Kanamori M, Li Z, Band H, et al. Negative regulation of EphA2 receptor by Cbl. Biochem Biophys Res Commun. 2002;296:214-20 pubmed
    ..Here, we report that EphA2, a member of Eph receptor tyrosine kinases is negatively regulated by Cbl...
  19. Duxbury M, Ito H, Zinner M, Ashley S, Whang E. Ligation of EphA2 by Ephrin A1-Fc inhibits pancreatic adenocarcinoma cellular invasiveness. Biochem Biophys Res Commun. 2004;320:1096-102 pubmed
    The Eph tyrosine kinases interact with ligands of the Ephrin family and have diverse cellular functions. EphA2 has been recognized to be an oncoprotein of importance in a range of cancers...
  20. Pandey A, Shao H, Marks R, Polverini P, Dixit V. Role of B61, the ligand for the Eck receptor tyrosine kinase, in TNF-alpha-induced angiogenesis. Science. 1995;268:567-9 pubmed
    B61, a cytokine-inducible endothelial gene product, is the ligand for the Eck receptor protein tyrosine kinase (RPTK)...
  21. Brantley Sieders D, Jiang A, Sarma K, Badu Nkansah A, Walter D, Shyr Y, et al. Eph/ephrin profiling in human breast cancer reveals significant associations between expression level and clinical outcome. PLoS ONE. 2011;6:e24426 pubmed publisher
    ..We found significant correlations between ephA2, ephA4, ephA7, ephB4, and ephB6 and overall and/or recurrence-free survival in large microarray datasets...
  22. Macrae M, Neve R, Rodriguez Viciana P, Haqq C, Yeh J, Chen C, et al. A conditional feedback loop regulates Ras activity through EphA2. Cancer Cell. 2005;8:111-8 pubmed
    The EphA2 receptor tyrosine kinase is frequently overexpressed in many cancers, including 40% of breast cancers...
  23. Tan W, Hou S, Jiang Z, Hu Z, Yang P, Ye J. Association of EPHA2 polymorphisms and age-related cortical cataract in a Han Chinese population. Mol Vis. 2011;17:1553-8 pubmed
    The gene for Eph-receptor tyrosinekinase-type A2 (EPHA2) has been shown to be involved in the pathogenesis of age-related cataract (ARC)...
  24. Flanagan J, Vanderhaeghen P. The ephrins and Eph receptors in neural development. Annu Rev Neurosci. 1998;21:309-45 pubmed
    ..This large family of ligands and receptors may make a major contribution to the accurate spatial patterning of connections and cell position in the nervous system. ..
  25. Zeng G, Hu Z, Kinch M, Pan C, Flockhart D, Kao C, et al. High-level expression of EphA2 receptor tyrosine kinase in prostatic intraepithelial neoplasia. Am J Pathol. 2003;163:2271-6 pubmed
    b>EphA2 is a transmembrane receptor tyrosine kinase that is overexpressed in many carcinomas...
  26. Cui X, Lee M, Yu G, Kim I, Yu H, Song E, et al. EFNA1 ligand and its receptor EphA2: potential biomarkers for hepatocellular carcinoma. Int J Cancer. 2010;126:940-9 pubmed publisher
    ..We further examined the expression of EFNA1 and its receptor EphA2 and determined their biological implications during the development and progression of HCC...
  27. Seiradake E, Harlos K, Sutton G, Aricescu A, Jones E. An extracellular steric seeding mechanism for Eph-ephrin signaling platform assembly. Nat Struct Mol Biol. 2010;17:398-402 pubmed publisher
    ..Upon activation, they form signaling clusters. We report crystal structures of the full ectodomain of human EphA2 (eEphA2) both alone and in complex with the receptor-binding domain of the ligand ephrinA5 (ephrinA5 RBD)...
  28. Miyazaki T, Kato H, Fukuchi M, Nakajima M, Kuwano H. EphA2 overexpression correlates with poor prognosis in esophageal squamous cell carcinoma. Int J Cancer. 2003;103:657-63 pubmed
    b>EphA2 is a member of the Eph family of receptor tyrosine kinases, which interact with cell-bound ligands known as ephrins...
  29. Kinch M, Moore M, Harpole D. Predictive value of the EphA2 receptor tyrosine kinase in lung cancer recurrence and survival. Clin Cancer Res. 2003;9:613-8 pubmed
    ..immunohistochemical analyses of a retrospective database of pathologic specimens were used to demonstrate that the EphA2 receptor kinase is frequently overexpressed in NSCLC...
  30. Kataoka H, Igarashi H, Kanamori M, Ihara M, Wang J, Wang Y, et al. Correlation of EPHA2 overexpression with high microvessel count in human primary colorectal cancer. Cancer Sci. 2004;95:136-41 pubmed
    ..Expression of two of them, EFNA1 ligand and its receptor, EPHA2, has been proposed to contribute to tumor-induced neovascularization...
  31. Pandey A, Lazar D, Saltiel A, Dixit V. Activation of the Eck receptor protein tyrosine kinase stimulates phosphatidylinositol 3-kinase activity. J Biol Chem. 1994;269:30154-7 pubmed
    The Eph/Eck subfamily of receptor protein tyrosine kinases is currently the largest subfamily of receptor protein tyrosine kinases with a dozen members (Van der Geer, P., Hunter, T., and Lindberg, R. A. (1994) Annu. Rev. Cell Biol...
  32. Udayakumar D, Zhang G, Ji Z, Njauw C, Mroz P, Tsao H. EphA2 is a critical oncogene in melanoma. Oncogene. 2011;30:4921-9 pubmed publisher
    b>EphA2 is a member of the Eph family of receptor tyrosine kinases and is highly expressed in many aggressive cancer types, including melanoma...
  33. Walker Daniels J, Hess A, Hendrix M, Kinch M. Differential regulation of EphA2 in normal and malignant cells. Am J Pathol. 2003;162:1037-42 pubmed
  34. Miao H, Burnett E, Kinch M, Simon E, Wang B. Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation. Nat Cell Biol. 2000;2:62-9 pubmed
    ..Here we show that activation of endogenous EphA2 kinase induces an inactive conformation of integrins and inhibits cell spreading, migration and integrin-mediated ..
  35. Taddei M, Parri M, Angelucci A, Onnis B, Bianchini F, Giannoni E, et al. Kinase-dependent and -independent roles of EphA2 in the regulation of prostate cancer invasion and metastasis. Am J Pathol. 2009;174:1492-503 pubmed publisher
    Ligand-activated Eph tyrosine kinases regulate cellular repulsion, morphology, adhesion, and motility. EphA2 kinase is frequently up-regulated in several different types of cancers, including prostate, breast, colon, and lung carcinomas, ..
  36. Yuan W, Chen Z, Wu S, Ge J, Chang S, Wang X, et al. Expression of EphA2 and E-cadherin in gastric cancer: correlated with tumor progression and lymphogenous metastasis. Pathol Oncol Res. 2009;15:473-8 pubmed publisher
    ..Immunohistochemistry of EphA2 and E-cadherin were performed on these tumor samples from 165 primary lesions of gastric cancer...
  37. Lindberg R, Hunter T. cDNA cloning and characterization of eck, an epithelial cell receptor protein-tyrosine kinase in the eph/elk family of protein kinases. Mol Cell Biol. 1990;10:6316-24 pubmed
    ..Analysis of RNA from 13 adult rat organs showed that the eck gene is expressed most highly in tissues that contain a high proportion of epithelial cells, e.g...
  38. Chang Q, Jorgensen C, Pawson T, Hedley D. Effects of dasatinib on EphA2 receptor tyrosine kinase activity and downstream signalling in pancreatic cancer. Br J Cancer. 2008;99:1074-82 pubmed publisher
    Eph receptors constitute the largest family of receptor tyrosine kinases in the human genome. EphA2 is one prominent member that is overexpressed and functionally altered in many invasive cancers, including pancreatic cancer...
  39. Brantley D, Cheng N, Thompson E, Lin Q, Brekken R, Thorpe P, et al. Soluble Eph A receptors inhibit tumor angiogenesis and progression in vivo. Oncogene. 2002;21:7011-26 pubmed
    ..Ephrin-A1 ligand was expressed in both tumor and endothelial cells, and EphA2 receptor was localized primarily in tumor-associated vascular endothelial cells...
  40. Lin Y, Han L, Kamat A, Merritt W, Landen C, Deavers M, et al. EphA2 overexpression is associated with angiogenesis in ovarian cancer. Cancer. 2007;109:332-40 pubmed
    b>EphA2 is overexpressed in the majority of ovarian cancers and predicts poor clinical outcome...
  41. Walker Daniels J, Riese D, Kinch M. c-Cbl-dependent EphA2 protein degradation is induced by ligand binding. Mol Cancer Res. 2002;1:79-87 pubmed
    The EphA2 receptor protein tyrosine kinase is overexpressed and functionally altered in a large number of human carcinomas...
  42. Cooper M, Son A, Komlos D, Sun Y, Kleiman N, Zhou R. Loss of ephrin-A5 function disrupts lens fiber cell packing and leads to cataract. Proc Natl Acad Sci U S A. 2008;105:16620-5 pubmed publisher
    ..We further demonstrate that ephrin-A5 interacts with the EphA2 receptor to regulate the adherens junction complex by enhancing recruitment of beta-catenin to N-cadherin...
  43. Kaul H, Riazuddin S, Shahid M, Kousar S, Butt N, Zafar A, et al. Autosomal recessive congenital cataract linked to EPHA2 in a consanguineous Pakistani family. Mol Vis. 2010;16:511-7 pubmed
    ..Logarithm of odds (LOD) scores were calculated, and Eph-receptor type-A2 (EPHA2), residing in the critical interval, was sequenced bidirectionally...
  44. Herath N, Spanevello M, Sabesan S, Newton T, Cummings M, Duffy S, et al. Over-expression of Eph and ephrin genes in advanced ovarian cancer: ephrin gene expression correlates with shortened survival. BMC Cancer. 2006;6:144 pubmed
    ..Greater than 10 fold over-expression of EphA1 and a more modest over-expression of EphA2 were observed in partially overlapping subsets of tumors. Over-expression of EphA1 strongly correlated (r = 0...
  45. Brannan J, Sen B, Saigal B, Prudkin L, Behrens C, Solis L, et al. EphA2 in the early pathogenesis and progression of non-small cell lung cancer. Cancer Prev Res (Phila). 2009;2:1039-49 pubmed publisher
    Overexpression of the receptor tyrosine kinase EphA2 occurs in non-small cell lung cancer (NSCLC) and a number of other human cancers...
  46. Li X, Wang Y, Wang Y, Zhen H, Yang H, Fei Z, et al. Expression of EphA2 in human astrocytic tumors: correlation with pathologic grade, proliferation and apoptosis. Tumour Biol. 2007;28:165-72 pubmed
    A high expression of EphA2 has been detected in many non-central nervous system tumors; however, the EphA2 expression in brain astrocytic tumors remains unclear...
  47. Jun G, Guo H, Klein B, Klein R, Wang J, Mitchell P, et al. EPHA2 is associated with age-related cortical cataract in mice and humans. PLoS Genet. 2009;5:e1000584 pubmed publisher
    ..We report that homozygous deletion of Epha2 in two independent strains of mice developed progressive cortical cataract...
  48. Herrem C, Tatsumi T, Olson K, Shirai K, Finke J, Bukowski R, et al. Expression of EphA2 is prognostic of disease-free interval and overall survival in surgically treated patients with renal cell carcinoma. Clin Cancer Res. 2005;11:226-31 pubmed
    ..of cell-to-cell contact in adult epithelial tissues, recent studies have shown that the receptor tyrosine kinase EphA2 is overexpressed in numerous epithelial-type carcinomas, with the greatest level of EphA2 expression observed in ..
  49. Brannan J, Dong W, Prudkin L, Behrens C, Lotan R, Bekele B, et al. Expression of the receptor tyrosine kinase EphA2 is increased in smokers and predicts poor survival in non-small cell lung cancer. Clin Cancer Res. 2009;15:4423-30 pubmed publisher
    Up-regulation of the receptor tyrosine kinase EphA2 has been shown in several epithelial cancers...
  50. Hahn A, Kaufmann J, Wies E, Naschberger E, Panteleev Ivlev J, Schmidt K, et al. The ephrin receptor tyrosine kinase A2 is a cellular receptor for Kaposi's sarcoma–associated herpesvirus. Nat Med. 2012;18:961-6 pubmed publisher
    ..We show that the ephrin receptor tyrosine kinase A2 (EphA2) is a cellular receptor for KSHV gH-gL. EphA2 co-precipitated with both gH-gL and KSHV virions...
  51. Sundaresan P, Ravindran R, Vashist P, Shanker A, Nitsch D, Talwar B, et al. EPHA2 polymorphisms and age-related cataract in India. PLoS ONE. 2012;7:e33001 pubmed publisher
    We investigated whether previously reported single nucleotide polymorphisms (SNPs) of EPHA2 in European studies are associated with cataract in India. We carried out a population-based genetic association study...
  52. Margaryan N, Strizzi L, Abbott D, Seftor E, Rao M, Hendrix M, et al. EphA2 as a promoter of melanoma tumorigenicity. Cancer Biol Ther. 2009;8:279-88 pubmed
    ..b>EphA2, a protein tyrosine kinase receptor commonly expressed in epithelial cells, has been found to be overexpressed and ..
  53. Kozlosky C, Vandenbos T, Park L, Cerretti D, Carpenter M. LERK-7: a ligand of the Eph-related kinases is developmentally regulated in the brain. Cytokine. 1997;9:540-9 pubmed
    ..In addition, a soluble form of LERK-7 will induce phosphorylation of eck expressed in a human duodenum adenocarcinoma cell line. LERK-7 expressed multiple transcripts (7.5-kb, 6...
  54. Wykosky J, Debinski W. The EphA2 receptor and ephrinA1 ligand in solid tumors: function and therapeutic targeting. Mol Cancer Res. 2008;6:1795-806 pubmed publisher
    ..Among these are EphA2 and ephrinA1, which are involved in the development and maintenance of many different types of solid tumors...
  55. Lee J, Stone R, Lee S, Nam E, Roh J, Nick A, et al. EphA2 targeted chemotherapy using an antibody drug conjugate in endometrial carcinoma. Clin Cancer Res. 2010;16:2562-70 pubmed publisher
    b>EphA2 overexpression is frequently observed in endometrial cancers and is predictive of poor clinical outcome...
  56. Kinch M, Carles Kinch K. Overexpression and functional alterations of the EphA2 tyrosine kinase in cancer. Clin Exp Metastasis. 2003;20:59-68 pubmed
    ..In Recent studies have demonstrated that the EphA2 receptor tyrosine kinase is frequently overexpressed and functionally altered in aggressive tumor cells, and that ..
  57. Pandey A, Duan H, Dixit V. Characterization of a novel Src-like adapter protein that associates with the Eck receptor tyrosine kinase. J Biol Chem. 1995;270:19201-4 pubmed
    ..Using a yeast two-hybrid screen to identify molecules that interact with the cytoplasmic domain of Eck, it was previously shown that activated Eck RPTK bound to and stimulated phosphatidylinositol 3-kinase (Pandey, A...
  58. Fritsche Guenther R, Noske A, Ungethüm U, Kuban R, Schlag P, Tunn P, et al. De novo expression of EphA2 in osteosarcoma modulates activation of the mitogenic signalling pathway. Histopathology. 2010;57:836-50 pubmed publisher
    ..Osteosarcoma samples were characterized using genome-wide microarrays: increased expression of the EphA2 receptor and its ligand EFNA1 was detected...
  59. Winter J, Roepcke S, Krause S, Müller E, Otto A, Vingron M, et al. Comparative 3'UTR analysis allows identification of regulatory clusters that drive Eph/ephrin expression in cancer cell lines. PLoS ONE. 2008;3:e2780 pubmed publisher
    ..Together our studies suggest that overexpression of HuR as found in many progressive tumors could be causative for disarranged Eph receptor to ephrin ligand ratios leading to a higher degree of tissue invasiveness. ..
  60. Thaker P, Deavers M, Celestino J, Thornton A, Fletcher M, Landen C, et al. EphA2 expression is associated with aggressive features in ovarian carcinoma. Clin Cancer Res. 2004;10:5145-50 pubmed
    b>EphA2 (epithelial cell kinase) is a transmembrane receptor tyrosine kinase that has been implicated in oncogenesis. There are no published data regarding the role of EphA2 in ovarian carcinoma, which is the focus of the present study...
  61. Himanen J, Yermekbayeva L, Janes P, Walker J, Xu K, Atapattu L, et al. Architecture of Eph receptor clusters. Proc Natl Acad Sci U S A. 2010;107:10860-5 pubmed publisher
    ..Here we present high-resolution structures of the complete EphA2 ectodomain and complexes with ephrin-A1 and A5 as the base unit of an Eph cluster...
  62. Larsen A, Pedersen M, Stockhausen M, Grandal M, van Deurs B, Poulsen H. Activation of the EGFR gene target EphA2 inhibits epidermal growth factor-induced cancer cell motility. Mol Cancer Res. 2007;5:283-93 pubmed
    b>EphA2 overexpression has been reported in many cancers and is believed to play an important role in tumor metastasis and angiogenesis...
  63. Salaita K, Nair P, Petit R, Neve R, Das D, Gray J, et al. Restriction of receptor movement alters cellular response: physical force sensing by EphA2. Science. 2010;327:1380-5 pubmed publisher
    Activation of the EphA2 receptor tyrosine kinase by ephrin-A1 ligands presented on apposed cell surfaces plays important roles in development and exhibits poorly understood functional alterations in cancer...
  64. Gale N, Holland S, Valenzuela D, Flenniken A, Pan L, Ryan T, et al. Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis. Neuron. 1996;17:9-19 pubmed
    ..This reciprocal compartmentalization implicates the Eph family in the formation of spatial boundaries that may help to organize the developing body plan. ..
  65. Giaginis C, Tsourouflis G, Zizi Serbetzoglou A, Kouraklis G, Chatzopoulou E, Dimakopoulou K, et al. Clinical significance of ephrin (eph)-A1, -A2, -a4, -a5 and -a7 receptors in pancreatic ductal adenocarcinoma. Pathol Oncol Res. 2010;16:267-76 pubmed publisher
  66. Brantley Sieders D, Zhuang G, Hicks D, Fang W, Hwang Y, Cates J, et al. The receptor tyrosine kinase EphA2 promotes mammary adenocarcinoma tumorigenesis and metastatic progression in mice by amplifying ErbB2 signaling. J Clin Invest. 2008;118:64-78 pubmed
    Overexpression of the receptor tyrosine kinase EPH receptor A2 (EphA2) is commonly observed in aggressive breast cancer and correlates with a poor prognosis...
  67. Nowakowski J, Cronin C, McRee D, Knuth M, Nelson C, Pavletich N, et al. Structures of the cancer-related Aurora-A, FAK, and EphA2 protein kinases from nanovolume crystallography. Structure. 2002;10:1659-67 pubmed
    ..report presents the structures of kinase domains for three cancer-associated protein kinases: ephrin receptor A2 (EphA2), focal adhesion kinase (FAK), and Aurora-A...
  68. Fang W, Ireton R, Zhuang G, Takahashi T, Reynolds A, Chen J. Overexpression of EPHA2 receptor destabilizes adherens junctions via a RhoA-dependent mechanism. J Cell Sci. 2008;121:358-68 pubmed publisher
    b>EPHA2 receptor tyrosine kinase is overexpressed in several human cancer types and promotes malignancy. However, the mechanisms by which EPHA2 promotes tumor progression are not completely understood...
  69. Hiramoto Yamaki N, Takeuchi S, Ueda S, Harada K, Fujimoto S, Negishi M, et al. Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism. J Cell Biol. 2010;190:461-77 pubmed publisher
    b>EphA2, a member of the Eph receptor family, is frequently overexpressed in a variety of human cancers, including breast cancers, and promotes cancer cell motility and invasion independently of its ligand ephrin stimulation...
  70. Yang N, Fernandez C, Richter M, Xiao Z, Valencia F, Tice D, et al. Crosstalk of the EphA2 receptor with a serine/threonine phosphatase suppresses the Akt-mTORC1 pathway in cancer cells. Cell Signal. 2011;23:201-12 pubmed publisher
    ..The EphA2 receptor is highly expressed in most cancer cell types, where it has disparate activities that are not well ..
  71. Fang W, Brantley Sieders D, Parker M, Reith A, Chen J. A kinase-dependent role for EphA2 receptor in promoting tumor growth and metastasis. Oncogene. 2005;24:7859-68 pubmed
    ..One family member in particular, the EphA2 receptor, has been linked to breast, prostate, lung and colon cancer, as well as melanoma...
  72. Parri M, Buricchi F, Taddei M, Giannoni E, Raugei G, Ramponi G, et al. EphrinA1 repulsive response is regulated by an EphA2 tyrosine phosphatase. J Biol Chem. 2005;280:34008-18 pubmed
    ..study aimed to investigate the role of low molecular weight protein-tyrosine phosphatase (LMW-PTP) in ephrinA1/EphA2 signaling...
  73. Chakraborty S, Veettil M, Bottero V, Chandran B. Kaposi's sarcoma-associated herpesvirus interacts with EphrinA2 receptor to amplify signaling essential for productive infection. Proc Natl Acad Sci U S A. 2012;109:E1163-72 pubmed publisher
    ..The tyrosine kinase EphrinA2 (EphA2), implicated in many cancers, was identified in this analysis. EphA2 was activated by KSHV...
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    ..The EphA2 receptor tyrosine kinase plays a pivotal role in tumor angiogenesis and an increased expression in glioma patients ..
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    ..and calcium ion concentration, and we provide evidence of a novel signaling pathway by which ligand-activated EphA2 suppresses Arf6 activity...