eosinophil peroxidase

Summary

Gene Symbol: eosinophil peroxidase
Description: eosinophil peroxidase
Alias: EPO, EPP, EPX-PEN, EPXD, eosinophil peroxidase
Species: human
Products:     eosinophil peroxidase

Top Publications

  1. Walsh M, Connell K, Sheahan A, Gleich G, Costello R. Eosinophil peroxidase signals via epidermal growth factor-2 to induce cell proliferation. Am J Respir Cell Mol Biol. 2011;45:946-52 pubmed publisher
    ..and release of intracellular mediators, including a set of cationic granule proteins that include eosinophil peroxidase. Studies suggest that eosinophils are involved in remodeling...
  2. van Diepen A, Brand H, de Waal L, Bijl M, Jong V, Kuiken T, et al. Host proteome correlates of vaccine-mediated enhanced disease in a mouse model of respiratory syncytial virus infection. J Virol. 2015;89:5022-31 pubmed publisher
    ..These proteins are involved in processes related to the direct influx of eosinophils (eosinophil peroxidase [Epx]) and to chemotaxis and extravasation processes (Chil3 [chitinase-like-protein 3]) as well as to ..
  3. Mohamed A, El Yamany M, El Batrawy F, Abdel Aziz M. JNJ7777120 Ameliorates Inflammatory and Oxidative Manifestations in a Murine Model of Contact Hypersensitivity via Modulation of TLR and Nrf2 Signaling. Inflammation. 2018;41:378-389 pubmed publisher
    ..This was accompanied by enhanced ear myeloperoxidase (MPO) and eosinophil peroxidase (EPO) activities as well as diminished glutathione (GSH) content and superoxide dismutase (SOD) activity...
  4. Jatsa H, Russo R, Pereira C, Aguilar E, Garcia C, Araújo E, et al. Improvement of the liver pathology by the aqueous extract and the n-butanol fraction of Sida pilosa Retz in Schistosoma mansoni-infected mice. J Ethnopharmacol. 2016;180:114-23 pubmed publisher
    ..Malondialdehyde (MDA), lipid hydroperoxydes (LOOH), catalase (CAT), superoxide dismutase (SOD), eosinophil peroxidase (EPO) and myeloperoxidase (MPO) were also measured...
  5. Carlson M, Venge P, Lampinen M. C3b-induced eosinophil degranulation involves PI3-kinases and is inhibited by protein kinase C activity. APMIS. 2011;119:119-26 pubmed publisher
    ..of eosinophil cationic protein (ECP), eosinophil protein X/eosinophil derived-neurotoxin (EPX/EDN) and eosinophil peroxidase (EPO) could be due to the involvement of different signal transduction pathways...
  6. Corrêa M, Andrade F, Gimenes A, Gil C. Anti-inflammatory effect of galectin-1 in a murine model of atopic dermatitis. J Mol Med (Berl). 2017;95:1005-1015 pubmed publisher
    ..and mast cells, which was verified by reduced expression of mouse mast cell protease 6 (mMCP6) and eosinophil peroxidase (EPX)...
  7. Santos Serafim Machado M, Ferreira Silva H, Rios R, Pires de Oliveira A, Vilany Queiroz Carneiro N, Santos Costa R, et al. The anti-allergic activity of Cymbopogon citratus is mediated via inhibition of nuclear factor kappa B (Nf-Κb) activation. BMC Complement Altern Med. 2015;15:168 pubmed publisher
    ..The parameters evaluated included: cellular infiltrate in bronchoalveolar lavage (BAL); eosinophil peroxidase activity (EPO); histopathological examination of the lung; serum levels of specific IgE, IgG1 and IgG2a; ..
  8. Morita H, Arae K, Unno H, Toyama S, Motomura K, Matsuda A, et al. IL-25 and IL-33 Contribute to Development of Eosinophilic Airway Inflammation in Epicutaneously Antigen-Sensitized Mice. PLoS ONE. 2015;10:e0134226 pubmed publisher
    ..the skin and lungs was determined by quantitative PCR, while the BALF levels of myeloperoxidase (MPO) and eosinophil peroxidase (EPO) and the serum levels of IgE were determined by ELISA...
  9. Babu D, Morgan A, Reiz B, Whittal R, Almas S, Lacy P, et al. Eosinophil peroxidase oxidizes isoniazid to form the active metabolite against M. tuberculosis, isoniazid-NAD. Chem Biol Interact. 2019;305:48-53 pubmed publisher
    ..Thus, the aim of the present study is to investigate the role of eosinophil peroxidase (EPO), a key eosinophil enzyme, during INH metabolism and the formation of its active metabolite, INH-NAD<..

More Information

Publications151 found, 100 shown here

  1. Abu Soud H, Maitra D, Shaeib F, Khan S, Byun J, Abdulhamid I, et al. Disruption of heme-peptide covalent cross-linking in mammalian peroxidases by hypochlorous acid. J Inorg Biochem. 2014;140:245-54 pubmed publisher
    Myeloperoxidase (MPO), lactoperoxidase (LPO) and eosinophil peroxidase (EPO) play a central role in oxidative damage in inflammatory disorders by utilizing hydrogen peroxide and halides/pseudo halides to generate the corresponding ..
  2. Hou L, Zhu L, Zhang M, Zhang X, Zhang G, Liu Z, et al. Participation of Antidiuretic Hormone (ADH) in Asthma Exacerbations Induced by Psychological Stress via PKA/PKC Signal Pathway in Airway-Related Vagal Preganglionic Neurons (AVPNs). Cell Physiol Biochem. 2017;41:2230-2241 pubmed publisher
    ..PKA and PKC inhibitors in psychological stress asthma, including reduced asthmatic inflammation (lower eosinophil peroxidase (EPO) activity, myeloperoxidase (MPO) activity, immunoglobulin E (IgE) level, and histamine release), ..
  3. Kaminuma O, Saeki M, Nishimura T, Kitamura N, Watanabe N, Hiroi T, et al. Differential Contribution of Adhesion Molecules to Th1 and Th2 Cell-Mediated Lung and Bowel Inflammation. Biol Pharm Bull. 2017;40:1801-1805 pubmed publisher
    ..challenge with the antigen, was indicated by the significant elevation of myeloperoxidase (MPO) and eosinophil peroxidase (EPO) activity...
  4. Oliveira T, Campos K, Cerqueira Lima A, Cana Brasil Carneiro T, da Silva Velozo E, Ribeiro Melo I, et al. Potential therapeutic effect of Allium cepa L. and quercetin in a murine model of Blomia tropicalis induced asthma. Daru. 2015;23:18 pubmed publisher
    ..We measured cell influx in bronchoalveolar lavage (BAL), eosinophil peroxidase (EPO) in lungs, serum levels of Bt-specific IgE, cytokines levels in BAL, and lung histology...
  5. Pitrez P, Gualdi L, Barbosa G, Sudbrack S, Ponzi D, Cao R, et al. Effect of different helminth extracts on the development of asthma in mice: The influence of early-life exposure and the role of IL-10 response. Exp Parasitol. 2015;156:95-103 pubmed publisher
    ..Cell counts in bronchoalveolar lavage (BAL), eosinophil peroxidase (EPO) from lung tissue, cytokine levels from BAL/spleen cell cultures, and lung histology were analyzed...
  6. Nauseef W. Biosynthesis of human myeloperoxidase. Arch Biochem Biophys. 2018;642:1-9 pubmed publisher
    Members of Chordata peroxidase subfamily [1] expressed in mammals, including myeloperoxidase (MPO), eosinophil peroxidase (EPO), lactoperoxidase (LPO), and thyroid peroxidase (TPO), express conserved motifs around the heme prosthetic ..
  7. Mariman R, Tielen F, Koning F, Nagelkerken L. The Probiotic Mixture VSL#3 Has Differential Effects on Intestinal Immune Parameters in Healthy Female BALB/c and C57BL/6 Mice. J Nutr. 2015;145:1354-61 pubmed publisher
    ..46] and Eosinophil peroxidase (Epx) (FC = 0.44) and upregulation of Il12rb1 (FC = 2.1), C-C chemokine receptor type 5 (Ccr5) (FC = 2...
  8. Sirohi H, Singh P, Iqbal N, Sharma P, Singh A, Kaur P, et al. Design of anti-thyroid drugs: Binding studies and structure determination of the complex of lactoperoxidase with 2-mercaptoimidazole at 2.30 Å resolution. Proteins. 2017;85:1882-1890 pubmed publisher
    ..LPO) belongs to mammalian heme peroxidase superfamily, which also includes myeloperoxidase (MPO), eosinophil peroxidase (EPO), and thyroid peroxidase (TPO)...
  9. Wang J, Mahmud S, Nguyen J, Slungaard A. Thiocyanate-dependent induction of endothelial cell adhesion molecule expression by phagocyte peroxidases: a novel HOSCN-specific oxidant mechanism to amplify inflammation. J Immunol. 2006;177:8714-22 pubmed
    Both eosinophil peroxidase (EPO) and neutrophil myeloperoxidase (MPO) preferentially oxidize SCN(-) to generate HOSCN, a weak, sulfhydryl-reactive oxidant, as a major physiologic product...
  10. Zakharova E, Sokolov A, Pavlichenko N, Kostevich V, Abdurasulova I, Chechushkov A, et al. Erythropoietin and Nrf2: key factors in the neuroprotection provided by apo-lactoferrin. Biometals. 2018;31:425-443 pubmed publisher
    ..human LF (rhLF) responded by expressing the HIF-1-alpha target genes, hence such proteins as erythropoietin (EPO), ceruloplasmin, etc. were synthesized in noticeable amounts...
  11. Wei X, Fang R, Yang Y, Bi X, Ren G, Luo A, et al. Protective effects of extracts from Pomegranate peels and seeds on liver fibrosis induced by carbon tetrachloride in rats. BMC Complement Altern Med. 2015;15:389 pubmed publisher
    ..Here we investigated whether the extracts of pomegranate peels (EPP) and seeds (EPS) have preventive efficacy on liver fibrosis induced by carbon tetrachloride (CCl4) in rats and ..
  12. Yagami A, Kajiwara N, Oboki K, Ohno T, Morita H, Sunnarborg S, et al. Amphiregulin is not essential for induction of contact hypersensitivity. Allergol Int. 2010;59:277-284 pubmed publisher
    ..The degree of ear swelling, the activities of myeloperoxidase (MPO) and eosinophil peroxidase (EPO) in inflammatory sites and the levels of FITC-specific immunoglobulin (Ig) in sera were determined by ..
  13. Odemuyiwa S, Ilarraza R, Davoine F, Logan M, Shayeganpour A, Wu Y, et al. Cyclin-dependent kinase 5 regulates degranulation in human eosinophils. Immunology. 2015;144:641-8 pubmed publisher
    ..Cdk5 inhibitors were used (roscovitine, AT7519 and small interfering RNA) to determine its role in eosinophil peroxidase (EPX) secretion...
  14. Makiya M, Herrick J, Khoury P, Prussin C, Nutman T, Klion A. Development of a suspension array assay in multiplex for the simultaneous measurement of serum levels of four eosinophil granule proteins. J Immunol Methods. 2014;411:11-22 pubmed publisher
    ..of major basic protein (MBP), eosinophil cationic protein (ECP), eosinophil derived neurotoxin (EDN) and eosinophil peroxidase (EPO) have been associated with eosinophilic disease severity...
  15. Ryu S, Na H, Sohn M, Han S, Choi W, In H, et al. Reduced expression of granule proteins during extended survival of eosinophils in splenocyte culture with GM-CSF. Immunol Lett. 2016;173:7-20 pubmed publisher
    ..Meanwhile, the expression of mRNAs encoding major basic protein-1 (MBP-1) and eosinophil peroxidase (EPO), two major eosinophil-derived granule proteins, was diminished significantly from the cultured ..
  16. Tahmasbpour Marzony E, Nejad Moghadam A, Ghanei M, Panahi Y. Sulfur mustard causes oxidants/antioxidants imbalance through the overexpression of free radical producing-related genes in human mustard lungs. Environ Toxicol Pharmacol. 2016;45:187-92 pubmed publisher
    ..of dual oxidases (DUOXs), aldehyde oxidase 1 (AOX1), thyroid peroxidase (TPO), myeloperoxidase (MPO) and eosinophil Peroxidase (EPO) were measured using RT(2) Profiler(™) PCR Array...
  17. Jang S, Lakshman S, Beshah E, Xie Y, Molokin A, Vinyard B, et al. Flavanol-Rich Cocoa Powder Interacts with Lactobacillus rhamnossus LGG to Alter the Antibody Response to Infection with the Parasitic Nematode Ascaris suum. Nutrients. 2017;9: pubmed publisher
    ..Pigs fed LGG had significantly reduced expression (p < 0.05) of Eosinophil peroxidase (EPX), Interleukin 13 (IL-13), Eotaxin 3 (CCL26), Toll-like receptor 2 (TLR2), ..
  18. Flemmig J, Schwarz P, Bäcker I, Leichsenring A, Lange F, Arnhold J. Fast and Specific Assessment of the Halogenating Peroxidase Activity in Leukocyte-enriched Blood Samples. J Vis Exp. 2016;: pubmed publisher
    ..method to evaluate halogenating peroxidase activity of the heme peroxidases, myeloperoxidase (MPO) and eosinophil peroxidase (EPO), i.e., the formation of hypochlorous and hypobromous acid (HOCl and HOBr)...
  19. Martin L, Franciosi J, Collins M, Abonia J, Lee J, Hommel K, et al. Pediatric Eosinophilic Esophagitis Symptom Scores (PEESS v2.0) identify histologic and molecular correlates of the key clinical features of disease. J Allergy Clin Immunol. 2015;135:1519-28.e8 pubmed publisher
    ..Esophageal biopsy samples were quantified for levels of eosinophils, eosinophil peroxidase (EPX) immunohistochemical staining, and mast cells...
  20. Moideen K, Kumar N, Nair D, Banurekha V, Bethunaickan R, Babu S. Heightened Systemic Levels of Neutrophil and Eosinophil Granular Proteins in Pulmonary Tuberculosis and Reversal following Treatment. Infect Immun. 2018;86: pubmed publisher
    ..3, major basic protein (MBP), eosinophil-derived neurotoxin (EDN), eosinophil cationic protein (ECP), and eosinophil peroxidase (EPX) in these individuals...
  21. Nouri A, Nait Mohamed F, Laraba Djebari F. New and safe formulation for scorpion immunotherapy: Comparative study between saponin and FCA adjuvants associated to attenuated venom. Vaccine. 2018;36:1720-1727 pubmed publisher
    ..Blood samples were collected every week, cell count, myeloperoxydase (MPO) and eosinophil peroxidase (EPO) activities and specific antibody titers were evaluated...
  22. Rivkin M, Simerzin A, Zorde Khvalevsky E, Chai C, Yuval J, Rosenberg N, et al. Inflammation-Induced Expression and Secretion of MicroRNA 122 Leads to Reduced Blood Levels of Kidney-Derived Erythropoietin and Anemia. Gastroenterology. 2016;151:999-1010.e3 pubmed publisher
    ..Secreted MIR122 reached the kidney and reduced expression of erythropoietin (Epo), which we identified as a MIR122 target gene...
  23. Cerqueira Lima A, Alcantara Neves N, de Carvalho L, Costa R, Barbosa Filho J, Piuvezam M, et al. Effects of Cissampelos sympodialis Eichl. and its alkaloid, warifteine, in an experimental model of respiratory allergy to Blomia tropicalis. Curr Drug Targets. 2010;11:1458-67 pubmed
    ..analyzed: (a) total cell numbers in bronchoalveolar fluid (BAF); (b) differential cell numbers in BAF; (c) eosinophil peroxidase (EPO) activity in BAF; (d) IgE serum levels by passive cutaneous anaphylaxis; (e) IL-5, IL-13, IL-10, and ..
  24. Li X, Zhang G, Sun N, Sun Y, Yang L, Du Y. Protective effects of erythropoietin on endotoxin-related organ injury in rats. J Huazhong Univ Sci Technolog Med Sci. 2013;33:680-686 pubmed publisher
    The protective effect of erythropoietin (EPO) on tissues following ischemia and reperfusion injuries remains poorly understood. We aimed to investigate the effect of EPO in preventing endotoxin-induced organ damage...
  25. Menon J, Ravikumar P, Pise A, Gyawali D, Hsia C, Nguyen K. Polymeric nanoparticles for pulmonary protein and DNA delivery. Acta Biomater. 2014;10:2643-52 pubmed publisher
    ..used to encapsulate plasmid DNA encoding yellow fluorescent protein (YFP) or rhodamine-conjugated erythropoietin (EPO) for inhalational delivery to rats...
  26. Nouri A, Laraba Djebari F. Enhancement of long-lasting immunoprotective effect against Androctonus australis hector envenomation using safe antigens: Comparative role of MF59 and Alum adjuvants. Vaccine. 2015;33:5756-63 pubmed publisher
    ..Blood samples were collected each week for cell count, evaluation of myeloperoxidase (MPO) and eosinoperoxydase (EPO) activities and antibody titer...
  27. van Zyl L, Du Preez J, Gerber M, du Plessis J, Viljoen J. Essential Fatty Acids as Transdermal Penetration Enhancers. J Pharm Sci. 2016;105:188-93 pubmed publisher
    ..Evening primrose oil (EPO), vitamin F, and Pheroid technology all contain fatty acids and were compared using a cream-based formulation...
  28. Khaksari M, Mehrjerdi F, Rezvani M, Safari F, Mirgalili A, Niknazar S. The role of erythropoietin in remote renal preconditioning on hippocampus ischemia/reperfusion injury. J Physiol Sci. 2017;67:163-171 pubmed publisher
    ..In contrast, renal failure hampers protective effects of RRPC, while exogenous administration of erythropoietin (EPO) significantly prevents the inhibiting effects of renal failure.
  29. Maniruzzaman M, Lam M, Molina C, Nokhodchi A. Study of the Transformations of Micro/Nano-crystalline Acetaminophen Polymorphs in Drug-Polymer Binary Mixtures. AAPS PharmSciTech. 2017;18:1428-1437 pubmed publisher
    ..S630), N-vinyl-2-pyrrolidone and vinyl acetate copolymer, and methacrylate-based cationic copolymer, Eudragit® EPO (EPO), were used as polymeric carriers to prepare drug/polymer binary mixtures...
  30. Hermann D. Enhancing the delivery of erythropoietin and its variants into the ischemic brain. ScientificWorldJournal. 2009;9:967-9 pubmed publisher
    The hematopoietic growth factor erythropoietin (EPO) and its neuroprotective, but not hematopoietic, variants asialoEPO, carbamylated EPO (CEPO), and low sialic acid EPO (Neuro-EPO) are attractive candidates for stroke treatment...
  31. Gassmann M, Muckenthaler M. Adaptation of iron requirement to hypoxic conditions at high altitude. J Appl Physiol (1985). 2015;119:1432-40 pubmed publisher
    ..We review the role of iron 1) in the oxygen sensing process and erythropoietin (Epo) synthesis, 2) in gene expression control mediated by the hypoxia-inducible factor-2 (HIF-2), and 3) as an oxygen ..
  32. Hamanaka R, Weinberg S, Reczek C, Chandel N. The Mitochondrial Respiratory Chain Is Required for Organismal Adaptation to Hypoxia. Cell Rep. 2016;15:451-459 pubmed publisher
    ..be a key regulator of the organismal response to hypoxic conditions, including renal production of erythropoietin (Epo). Therefore, we conditionally deleted expression of TFAM in mouse epidermal keratinocytes...
  33. Cariou A, Deye N, Vivien B, Richard O, Pichon N, Bourg A, et al. Early High-Dose Erythropoietin Therapy After Out-of-Hospital Cardiac Arrest: A Multicenter, Randomized Controlled Trial. J Am Coll Cardiol. 2016;68:40-9 pubmed publisher
    ..a clinical benefit in treating out-of-hospital cardiac arrest (OHCA) patients with a high dose of erythropoietin (Epo) analogs...
  34. Perreault A, Benton M, Koury M, Brandt S, Venters B. Epo reprograms the epigenome of erythroid cells. Exp Hematol. 2017;51:47-62 pubmed publisher
    The hormone erythropoietin (Epo) is required for erythropoiesis, yet its molecular mechanism of action remains poorly understood, particularly with respect to chromatin dynamics...
  35. Hernández C, Burgos C, Gajardo A, Silva Grecchi T, Gavilan J, Toledo J, et al. Neuroprotective effects of erythropoietin on neurodegenerative and ischemic brain diseases: the role of erythropoietin receptor. Neural Regen Res. 2017;12:1381-1389 pubmed publisher
    Erythropoietin (Epo) is a fundamental hormone in the regulation of hematopoiesis, and other secondary roles mediated by the binding of the hormone to its specific receptor (EpoR), which leads to an activation of key signaling pathways ..
  36. Saal W, Wyttenbach N, Alsenz J, Kuentz M. Interactions of dimethylaminoethyl methacrylate copolymer with non-acidic drugs demonstrated high solubilization in vitro and pronounced sustained release in vivo. Eur J Pharm Biopharm. 2018;125:68-75 pubmed publisher
    Recent work demonstrated remarkable solubilization effects of methacrylate-copolymer Eudragit EPO (EPO) not only with acidic drugs but interestingly also with poorly soluble basic compounds...
  37. Jonker J, Musters S, Vlaming M, Plosch T, Gooijert K, Hillebrand M, et al. Breast cancer resistance protein (Bcrp1/Abcg2) is expressed in the harderian gland and mediates transport of conjugated protoporphyrin IX. Am J Physiol Cell Physiol. 2007;292:C2204-12 pubmed
    ..in ferrochelatase, which mediates the final step in heme biosynthesis, leads to erythropoietic protoporphyria (EPP), a photosensitivity syndrome caused by the accumulation of PPIX in the skin...
  38. Yu Y, Su K, Kou Y, Guo B, Lee K, Wei J, et al. Role of transient receptor potential vanilloid 1 in regulating erythropoietin-induced activation of endothelial nitric oxide synthase. Acta Physiol (Oxf). 2017;219:465-477 pubmed publisher
    Erythropoietin (EPO), the key hormone involved in erythropoiesis, beneficially affects endothelial cells (ECs), but the detailed mechanisms are yet to be completely understood...
  39. Lu H, Wu X, Wang Z, Li L, Chen W, Yang M, et al. Erythropoietin-activated mesenchymal stem cells promote healing ulcers by improving microenvironment. J Surg Res. 2016;205:464-473 pubmed publisher
    ..Erythropoietin (EPO) is an anti-inflammatory, proangiogenic cytokine...
  40. Zhong C, Zhang X. Age-associated expression of erythropoietin and its receptor in rat spiral ganglion neurons and its association with neuronal apoptosis and hearing alterations. Mol Med Rep. 2017;15:228-234 pubmed publisher
    The present study aimed to determine the expression of erythropoietin (EPO) and the EPO receptor (EPOR) in spiral ganglion neurons (SGNs) in the inner ear of rats of various ages, and the associated neuronal apoptosis and hearing ..
  41. Desharnais P, Naud J, Ayotte C. Immunomagnetic beads-based isolation of erythropoietins from urine and blood for sports anti-doping control. Drug Test Anal. 2017;: pubmed publisher
    ..ESA in serum/plasma samples using a combination of streptavidin-coated immunomagnetic beads and biotinylated anti-EPO polyclonal antibodies...
  42. Ohlsson A, Aher S. Early erythropoiesis-stimulating agents in preterm or low birth weight infants. Cochrane Database Syst Rev. 2017;11:CD004863 pubmed publisher
    Preterm infants have low plasma levels of erythropoietin (EPO), providing a rationale for the use of erythropoiesis-stimulating agents (ESAs) to prevent or treat anaemia and to provide neuro protection and protection against necrotising ..
  43. Mesonzhnik N, Postnikov P, Appolonova S, Krotov G. Characterization and detection of EPO-Fc fusion proteins using LC-MS. J Proteome Res. 2017;: pubmed publisher
    b>EPO-Fc fusion proteins are potential drug candidates that have been designed for the treatment of anaemia in humans by stimulating erythrocyte production...
  44. Pottage A. Dignity again. Reprod Biomed Online. 2018;36:285-287 pubmed publisher
    ..discuss a challenge to Stanford's time-lapse embryo monitoring patent, currently before the European Patent Office (EPO)...
  45. Correa Costa M, Gallo D, Csizmadia E, Gomperts E, Lieberum J, Hauser C, et al. Carbon monoxide protects the kidney through the central circadian clock and CD39. Proc Natl Acad Sci U S A. 2018;115:E2302-E2310 pubmed publisher
    ..in expression of the circadian rhythm protein Period 2 (Per2) and a fivefold increase in serum erythropoietin (EPO), both of which contribute to abrogation of kidney IRI...
  46. Polenakovic M. Dialysis in adults in year 2000 in the Republic of Macedonia. Int J Artif Organs. 2002;25:386-90 pubmed
    ..mode of application was subcutaneous and the initial dose is 20 U/kg body weight and the mean maintenance dose of EPO per patient weekly is 4,000 U...
  47. Barton S, McDougall A, Melville J, Moss T, Zahra V, Lim T, et al. Differential short-term regional effects of early high dose erythropoietin on white matter in preterm lambs after mechanical ventilation. J Physiol. 2016;594:1437-49 pubmed publisher
    ..We investigated the impact of an early high dose of recombinant human erythropoietin (EPO) on ventilation-induced WM changes in preterm lambs...
  48. Fan S, Li X, Tie L, Pan Y, Li X. KIAA0101 is associated with human renal cell carcinoma proliferation and migration induced by erythropoietin. Oncotarget. 2016;7:13520-37 pubmed publisher
    Erythropoietin (EPO) is a frequently prescribed anti-anemic drug for patients with advanced renal carcinoma...
  49. Purroy C, Fairchild R, Tanaka T, Baldwin W, Manrique J, Madsen J, et al. Erythropoietin Receptor-Mediated Molecular Crosstalk Promotes T Cell Immunoregulation and Transplant Survival. J Am Soc Nephrol. 2017;28:2377-2392 pubmed publisher
    ..Herein we test the hypothesis that EPO, a hormone predominantly produced by the adult kidney, has immunomodulating properties that are required for ..
  50. Gilboa D, Haim Ohana Y, Deshet Unger N, Ben Califa N, Hiram Bab S, Reuveni D, et al. Erythropoietin enhances Kupffer cell number and activity in the challenged liver. Sci Rep. 2017;7:10379 pubmed publisher
    Erythropoietin (EPO) is the main hormone driving mammalian erythropoiesis, with activity mediated via the surface receptor, EPO-R, on erythroid progenitor cells...
  51. Ozkunt O, Sariyilmaz K, Gemalmaz H, Gürgen S, Yener U, Dikici F. Investigation of efficacy of treatment in spinal cord injury: Erythropoietin versus methylprednisolone. J Orthop Surg (Hong Kong). 2017;25:2309499017739481 pubmed publisher
    ..of platelet-derived growth factor (PDGF)-? and glial fibrillary acidic protein (GFAP) in rats with spinal cord injury as a marker of neurologic recovery between groups treated with erythropoietin (EPO) and methylprednisolone (MP).
  52. Seifi B, Kadkhodaee M, Ranjbaran M, Bakhshi E. Nephroprotection through the Akt/eNOS pathway by centrally administered erythropoietin in a rat model of fixed-volume hemorrhage. Life Sci. 2018;193:180-185 pubmed publisher
    This study was designed to investigate the protective effects of centrally administered erythropoietin (EPO) on brain oxidative stress and inflammatory markers to protect the kidneys during hemorrhagic shock (HS)...
  53. Katakura F, Yabu T, Yamaguchi T, Miyamae J, Shirinashihama Y, Nakanishi T, et al. Exploring erythropoiesis of common carp (Cyprinus carpio) using an in vitro colony assay in the presence of recombinant carp kit ligand A and erythropoietin. Dev Comp Immunol. 2015;53:13-22 pubmed publisher
    ..CFU-E) progenitors, and serves to examine functions of erythropoietic growth factors like Erythropoietin (Epo) and Kit ligand...
  54. Fabrizio C, Lam T, Hirschmann M, Pang I, Yu N, Wang X, et al. Parental emotional management benefits family relationships: A randomized controlled trial in Hong Kong, China. Behav Res Ther. 2015;71:115-24 pubmed publisher
    ..objectives of our randomized controlled trial were to test the effectiveness of our Effective Parenting Programme (EPP) to increase the use of emotional management strategies (primary outcome) and enhance the parent-child relationship ..
  55. Zhou Y, Zhao X, Tang Y, Zhu L, Jiang J, Lu X. Erythropoietin Inhibits the Increase of Pulmonary Labile Zinc and the Expression of Inflammatory Mediators Following Subarachnoid Hemorrhage in Rats. Neurocrit Care. 2016;24:472-80 pubmed publisher
    ..levels of labile zinc and certain proinflammatory factors in rat lung and determined the effect of erythropoietin (EPO) on the pulmonary labile zinc and the inflammatory factor after SAH in rats...
  56. Oikonomidou P, Casu C, Yang Z, Crielaard B, Shim J, Rivella S, et al. Polycythemia is associated with bone loss and reduced osteoblast activity in mice. Osteoporos Int. 2016;27:1559-1568 pubmed publisher
    ..activity in a mouse model of PV and another mouse of polycythemia and elevated circulating erythropoietin (EPO). Our results are important for patients with PV or those treated with recombinant EPO (rEPO)...
  57. Gutierrez F, Gonzalez de la Fuente G, Nazco G, Oramas J, Batista N. Hematological toxicity of carboplatin for gynecological cancer according to body mass index. Eur J Clin Pharmacol. 2016;72:1083-9 pubmed publisher
    ..as treatment modifications and the need for granulocyte colony-stimulating factors (G-CSF) and/or erythropoietin (EPO) or packed red blood cells (PRBC)...
  58. Donati A, Damiani E, Zuccari S, Domizi R, Scorcella C, Girardis M, et al. Effects of short-term hyperoxia on erythropoietin levels and microcirculation in critically Ill patients: a prospective observational pilot study. BMC Anesthesiol. 2017;17:49 pubmed publisher
    ..followed by rapid return to normoxia creates a condition of 'relative hypoxia' which stimulates erythropoietin (EPO) production. Alterations in glutathione and reactive oxygen species (ROS) may be involved in this process...
  59. Dias R, Rodrigues T, Rombo D, Ribeiro F, Rodrigues J, McGarvey J, et al. Erythropoietin Induces Homeostatic Plasticity at Hippocampal Synapses. Cereb Cortex. 2017;:1-15 pubmed publisher
    The cytokine erythropoietin (EPO) is the master regulator of erythropoiesis...
  60. Nakamura M, Zhang Y, Yang Y, Sonmez C, Zheng W, Huang G, et al. Off-tumor targets compromise antiangiogenic drug sensitivity by inducing kidney erythropoietin production. Proc Natl Acad Sci U S A. 2017;114:E9635-E9644 pubmed publisher
    ..in human cancer patients, the anti-VEGF drug-induced kidney hypoxia augments circulating levels of erythropoietin (EPO)...
  61. Eisenga M, Kieneker L, Touw D, Nolte I, van der Meer P, Huls G, et al. Active Smoking and Hematocrit and Fasting Circulating Erythropoietin Concentrations in the General Population. Mayo Clin Proc. 2018;93:337-343 pubmed publisher
    ..smoking can induce erythrocytosis, which is commonly believed to result from elevated serum erythropoietin (EPO) levels. Currently, however, this notion is only alleged, without data available to substantiate it...
  62. Lam C, Chan P, Lee P, Lau K, Kong A, Gong A, et al. Chemical and biological assessment of Jujube (Ziziphus jujuba)-containing herbal decoctions: Induction of erythropoietin expression in cultures. J Chromatogr B Analyt Technol Biomed Life Sci. 2016;1026:254-262 pubmed publisher
    ..The herbal treatment stimulated the amount of mRNA and protein expressions of erythropoietin (EPO) via the activation of hypoxia response elements: the three herbal decoctions showed different activation...
  63. Hines Beard J, Bond W, Backstrom J, Rex T. Virus-mediated EpoR76E gene therapy preserves vision in a glaucoma model by modulating neuroinflammation and decreasing oxidative stress. J Neuroinflammation. 2016;13:39 pubmed publisher
    ..determine if modulation of neuroinflammation or oxidative stress played a role in the neuroprotective activity of EPO.R76E. Five-month-old DBA/2J mice were treated with either rAAV...
  64. Dupuis C, Michelet D, Hilly J, Diallo T, Vidal C, Delivet H, et al. Predictive factors for homologous transfusion during paediatric scoliosis surgery. Anaesth Crit Care Pain Med. 2015;34:327-32 pubmed publisher
    ..2% for transfusion). Multivariate sensitivity analysis excluding patients with no preoperative administration of EPO found similar results...
  65. Bamgbola O. Spectrum of anemia after kidney transplantation: pathophysiology and therapeutic implications. Clin Transplant. 2016;30:1185-1194 pubmed publisher
    ..is also a blunted response by oxidative inflammation to the effectiveness of supranormal levels of erythropoietin (EPO) release during ischemic-reperfusion allograft injury...
  66. Wang D, Song Y, Zhang J, Pang W, Wang X, Zhu Y, et al. AMPK-KLF2 signaling pathway mediates the proangiogenic effect of erythropoietin in endothelial colony forming cells. Am J Physiol Cell Physiol. 2017;:ajpcell.00257.2016 pubmed publisher
    ..Erythropoietin (EPO) is a promising cytokine participating in angiogenesis...
  67. Miller J, Church T, Leonoudakis D, Lariosa Willingham K, Frigon N, Tettenborn C, et al. Discovery and Characterization of Nonpeptidyl Agonists of the Tissue-Protective Erythropoietin Receptor. Mol Pharmacol. 2015;88:357-67 pubmed publisher
    Erythropoietin (EPO) and its receptor are expressed in a wide variety of tissues, including the central nervous system...
  68. Wang R, Zhao H, Li J, Duan Y, Fan Z, Tao Z, et al. Erythropoietin attenuates axonal injury after middle cerebral artery occlusion in mice. Neurol Res. 2017;39:545-551 pubmed publisher
    Erythropoietin (EPO) confers potent neuroprotection against ischemic injury through a variety of mechanisms. However, the protective effect of EPO on axons after cerebral ischemia in adult mice is rarely covered...
  69. Zhang W, Zhang L, Liu J, Zhang L, Zhang J, Tang P. Repairing sciatic nerve injury with an EPO-loaded nerve conduit and sandwiched-in strategy of transplanting mesenchymal stem cells. Biomaterials. 2017;142:90-100 pubmed publisher
    ..Here we developed a novel strategy for repairing sciatic nerve injury by EPO-loaded Chitosan nerve conduit (EPO/Chi) and sandwiched-in transplantation of mesenchymal stem cells (MSCs)...
  70. Arsenault P, Pei F, Lee R, Kerestes H, Percy M, Keith B, et al. A knock-in mouse model of human PHD2 gene-associated erythrocytosis establishes a haploinsufficiency mechanism. J Biol Chem. 2013;288:33571-84 pubmed publisher
    ..regulated by PHD, activates numerous genes, including ones involved in erythropoiesis, such as the ERYTHROPOIETIN (EPO) gene. Recent studies have implicated PHD2 as the key PHD isoform regulating red cell mass...
  71. Touma Z, Thavaneswaran A, Chandran V, Pellett F, Cook R, Gladman D. Clinical and Demographic Characteristics of Erosion-free and Erosion-present Status in Psoriatic Arthritis in a Cohort Study. J Rheumatol. 2016;43:1057-62 pubmed publisher
    ..We aimed to determine the prevalence, characteristics, and predictors of erosion-free patients (EFP) as compared with erosion-present patients (EPP) among patients with PsA followed prospectively.
  72. Buccisano F, Piccioni A, Nobile C, Criscuolo M, Niscola P, Tatarelli C, et al. Real-life use of erythropoiesis-stimulating agents in myelodysplastic syndromes: a "Gruppo Romano Mielodisplasie (GROM)" multicenter study. Ann Hematol. 2016;95:1059-65 pubmed publisher
    ..The 40.000-UI/week erythropoietin (EPO)-alpha and 30.000-UI/week EPO-beta starting dose were defined "standard," and 80,000 UI/week EPO-alpha and 60...
  73. Frey H, Moreth K, Hsieh L, Zeng Brouwers J, Rathkolb B, Fuchs H, et al. A novel biological function of soluble biglycan: Induction of erythropoietin production and polycythemia. Glycoconj J. 2017;34:393-404 pubmed publisher
    ..characterized by a selective increase in circulating mature erythrocytes, is caused by enhanced erythropoietin (Epo) concentrations triggered by hypoxia-inducible factor-2? (HIF-2?)...
  74. Arsenault P, Song D, Bergkamp M, Ravaschiere A, Navalsky B, Lieberman P, et al. Identification of Small-Molecule PHD2 Zinc Finger Inhibitors that Activate Hypoxia Inducible Factor. Chembiochem. 2016;17:2316-2323 pubmed publisher
    ..and PHD2 has emerged as a particularly critical one for regulating HIF target genes such as erythropoietin (EPO), which controls red cell mass and hematocrit...
  75. Kaitsuka T, Kobayashi K, Otsuka W, Kubo T, Hakim F, Wei F, et al. Erythropoietin facilitates definitive endodermal differentiation of mouse embryonic stem cells via activation of ERK signaling. Am J Physiol Cell Physiol. 2017;312:C573-C582 pubmed publisher
    ..factor, which induced the efficiency of pancreatic differentiation and found that treatment with erythropoietin (EPO) facilitated the differentiation of mouse embryonic stem cells (ESCs) into definitive endoderm...
  76. Tsiakalos A, Voumvas T, Psarris A, Oikonomou C, Ziogas D, Ketikoglou I, et al. Circulating autoantibodies to endogenous erythropoietin are associated with chronic hepatitis C virus infection-related anemia. Hepatobiliary Pancreat Dis Int. 2017;16:289-295 pubmed
    ..Circulating autoantibodies to endogenous erythropoietin (anti-EPO) have been detected in patients with chronic viral infections and were correlated to anemia...
  77. Wang K, Wu J, Cheng F, Huang X, Zeng F, Zhang Y. Acidic Polysaccharide from Angelica sinensis Reverses Anemia of Chronic Disease Involving the Suppression of Inflammatory Hepcidin and NF-?B Activation. Oxid Med Cell Longev. 2017;2017:7601592 pubmed publisher
    ..expression, mobilized iron from the liver and spleen, increased serum iron levels, caused an elevation of serum EPO, and effectively relieved the anemia...
  78. Mutschler M, Magin A, Buerge M, Roelz R, Schanne D, Will B, et al. NF-E2 overexpression delays erythroid maturation and increases erythrocyte production. Br J Haematol. 2009;146:203-17 pubmed publisher
    ..NF-E2 overexpression increases proliferation and promotes cellular viability in the absence of erythropoietin (EPO). EPO-independent growth is a hallmark of PV...
  79. Gardenghi S, Grady R, Rivella S. Anemia, ineffective erythropoiesis, and hepcidin: interacting factors in abnormal iron metabolism leading to iron overload in ?-thalassemia. Hematol Oncol Clin North Am. 2010;24:1089-107 pubmed publisher
    ..to the pathway(s) controlling the expression of hepcidin, which is the main regulator of iron metabolism, and the Epo/EpoR/Jak2/Stat5 signaling pathway, which regulates erythropoiesis...
  80. Barandon S, Balès M, Melchior M, Glangeaud Freudenthal N, Pambrun E, Bois C, et al. [Early prenatal interview and antenatal education for childbirth and parenthood: Associated psychosocial and obstetric characteristics in women of the ELFE cohort]. J Gynecol Obstet Biol Reprod (Paris). 2016;45:599-607 pubmed publisher
    Early prenatal interview (Entretien prénatal précoce [EPP]) is aimed at defining with couples their physical, psychological and social needs during perinatal period...
  81. Hoonakker M, Doignon Camus N, Bonnefond A. Performance monitoring mechanisms activated before and after a response: A comparison of aware and unaware errors. Biol Psychol. 2016;120:53-60 pubmed publisher
    ..Likewise, analysis of the error-preceding positivity (EPP) revealed specific modulation in frontal scalp regions according to error type...
  82. Okwuosa T, Soares C, Gollwitzer V, Habashy R, Timmins P, Alhnan M. On demand manufacturing of patient-specific liquid capsules via co-ordinated 3D printing and liquid dispensing. Eur J Pharm Sci. 2018;118:134-143 pubmed publisher
    ..Polymethacrylate shells (Eudragit EPO and RL) for immediate and extended release were fabricated using FDM 3D printing and simultaneously filled using a ..
  83. Garcia Santos D, Hamdi A, Saxova Z, Fillebeen C, Pantopoulos K, Horvathova M, et al. Inhibition of heme oxygenase ameliorates anemia and reduces iron overload in ?-thalassemia mouse model. Blood. 2017;: pubmed publisher
    ..SnPP administration led to an increase in erythropoietin (EPO) and hepcidin serum levels, changes that were accompanied by an alleviation of ineffective erythropoiesis in Th3/<..
  84. Mayer B, Nemeth K, Krepuska M, Myneni V, Maric D, Tisdale J, et al. Vasopressin stimulates the proliferation and differentiation of red blood cell precursors and improves recovery from anemia. Sci Transl Med. 2017;9: pubmed publisher
    ..AVP increases phosphorylation of signal transducer and activator of transcription 5, as erythropoietin (EPO) does...
  85. Jung J, Kang H, Lee H, Park H, Cho S, Min K, et al. Expression levels of eosinophil granule protein mRNAs in induced sputum reflect airway hyperresponsiveness and airflow limitation. Tohoku J Exp Med. 2014;233:49-56 pubmed
    ..of eosinophil granule proteins, including major basic protein (MBP), eosinophil cationic protein (ECP), eosinophil peroxidase (EPO), and eosinophil-derived neurotoxin...
  86. Larmuseau M, Matthijs K, Wenseleers T. Cuckolded Fathers Rare in Human Populations. Trends Ecol Evol. 2016;31:327-329 pubmed publisher
    Contemporary data of extra-pair paternity (EPP) in human populations may be biased by the use of modern contraceptives. Studies have now estimated historical EPP rates in several human populations...
  87. Wei S, Luo C, Yu S, Gao J, Liu C, Wei Z, et al. Erythropoietin ameliorates early brain injury after subarachnoid haemorrhage by modulating microglia polarization via the EPOR/JAK2-STAT3 pathway. Exp Cell Res. 2017;361:342-352 pubmed publisher
    ..However, the mechanisms of this beneficial effect are still poorly understood. Recent research has suggested that EPO shows anti-inflammatory properties...
  88. Lee H, Zeng J, Bowen S, Rengan R. Proton Therapy for Malignant Pleural Mesothelioma: A Three Case Series Describing the Clinical and Dosimetric Advantages of Proton-Based Therapy. Cureus. 2017;9:e1705 pubmed publisher
    ..We present three patients who received IMPT to 54 Gy after extrapleural pneumonectomy (EPP), with two patients receiving boosts to 66 and 60 Gy...
  89. Galal S, Abdel Rafei M, Hasan H. Cholinergic and cytoprotective signaling cascades mediate the mitigative effect of erythropoietin on acute radiation syndrome. Can J Physiol Pharmacol. 2018;96:442-458 pubmed publisher
    The present investigation aimed to evaluate the radiomitigative efficacy of the recombinant human erythropoietin (EPO) against acute radiation syndrome (ARS) in a rat model...
  90. Khoo S, Al Alawi M, Walsh M, Hannigan K, Glynn S, Thornton M, et al. Eosinophil peroxidase induces the expression and function of acid-sensing ion channel-3 in allergic rhinitis: in vitro evidence in cultured epithelial cells. Clin Exp Allergy. 2012;42:1028-39 pubmed publisher
    ..A mechanism of induction of ASIC-3 expression relevant to AR was suggested by the finding that eosinophil peroxidase (EPO), acting via ERK1/2, induced the expression of ASIC-3 in epithelial cells...
  91. Barman Aksözen J, C Wiek P, Bansode V, Koentgen F, Trüb J, Pelczar P, et al. Modeling the ferrochelatase c.315-48C modifier mutation for erythropoietic protoporphyria (EPP) in mice. Dis Model Mech. 2017;10:225-233 pubmed publisher
    Erythropoietic protoporphyria (EPP) is caused by deficiency of ferrochelatase (FECH), which incorporates iron into protoporphyrin IX (PPIX) to form heme...
  92. Lu J, Dai Q, Ma G, Zhu Y, Chen B, Li B, et al. Erythropoietin Attenuates Cardiac Dysfunction in Rats by Inhibiting Endoplasmic Reticulum Stress-Induced Diabetic Cardiomyopathy. Cardiovasc Drugs Ther. 2017;31:367-379 pubmed publisher
    ..We aimed to verify whether erythropoietin (EPO) attenuates cardiac dysfunction by suppressing ER stress in diabetic rats...